ENTRY       EC 1.1.1.1
NAME        Alcohol dehydrogenase
            Aldehyde reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alcohol:NAD+ oxidoreductase
REACTION    Alcohol + NAD+ = Aldehyde or Ketone + NADH
SUBSTRATE   NAD+
            Primary alcohol
            Secondary alcohol
            Cyclic secondary alcohol
            Hemiacetal
PRODUCT     Aldehyde
            Ketone
            NADH
COFACTOR    Zinc
COMMENT     A zinc protein. Acts on primary or secondary alcohols or
            hemiacetals; the animal, but not the yeast, enzyme acts also on
            cyclic secondary alcohols
            The insect enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b0356(adhC) b1241(adhE) b1478(adhP) b3589(yiaY)
            ECE: Z0456(adhC) Z2016(adhE) Z2232(adhP) Z5010(yiaY)
            ECS: ECs0411 ECs1741 ECs2082 ECs4466
            YPE: YPO2180(adhE)
            HIN: HI0185(adhC)
            PMU: PM1453(adh2)
            XFA: XF1746 XF2389
            VCH: VC1147 VC2033
            PAE: PA2119 PA2158 PA2188 PA3629(adhC) PA5427(adhA)
            NME: NMB0546 NMB1304
            NMA: NMA0725(adhA) NMA1518(adhC)
            MLO: mlr0872 mlr1136 mlr1178
            SME: SMa1156 SMa1296(adhA1) SMa2113(adhC2) SMc01270(adhC1)
                 SMc04270
            CCR: CC2516 CC3029
            BSU: BG11902(adhB) BG11941(gbsB)
            BHA: BH1829(adhB)
            SAU: SA0143(adhE) SA0562(adh1)
            SAV: SAV0142(adh2) SAV0595(adh1)
            LLA: L13145(adhE) L55758(adhA)
            SPY: SPy0044(adhA)
            SPN: SP0285 SP2026 SP2157
            SPR: spr0262(adhP) spr1670(adhB) spr1866(adh) spr1963(adh2)
            CAC: CAC3375
            MTU: Rv0761c(adhB) Rv1862(adhA)
            MTC: MT0786 MT1911
            MLE: ML2053
            SYN: sll0990
            AAE: aq_1240(adh2) aq_1362(adh1)
            TMA: TM0111 TM0920
            AFU: AF0024 AF0339 AF2019 AF2101
            HAL: VNG1821G(adh4)
            TAC: Ta0832 Ta0833 Ta0841
            TVO: TVG0387048 TVG0995648 TVG1348694
            PHO: PH0743
            PAB: PAB1511
            APE: APE1245 APE1557 APE1963 APE2239
            SSO: SSO0472(adh-1) SSO0764(adh-2) SSO1646(adh-5) SSO2494(adh-8)
                 SSO2536(adh-10) SSO2878(adh-13)
            STO: ST0038 ST0053 ST0075 ST0480
            SCE: YBR145W(ADH5) YDL168W(SFA1) YGL256W(ADH4) YMR083W(ADH3)
                 YMR303C(ADH2) YOL086C(ADH1)
            SPO: ADH1(adh1) SPAC5H10.06C(spac5h10.06c) SPCC13B11.04C
            ATH: At1g77120(F22K20.19)
            CEL: K12G11.3 K12G11.4
            DME: CG3425(T3dh) CG3481(Adh) CG6598(Fdh)
            MMU: 1098256(Daq1) 87921(Adh1) 87926(Adh3) 87929(Adh5)
            HSA: 124(ADH1A) 125(ADH1B) 126(ADH1C) 127(ADH4) 128(ADH5)
                 130(ADH6) 131(ADH7)
DISEASE     MIM: 103700  Alcohol dehydrogenase (class I), alpha polypeptide
            MIM: 103720  Alcohol dehydrogenase (class I), beta polypeptide
            MIM: 103730  Alcohol dehydrogenase (class I), gamma polypeptide
            MIM: 103740  Alcohol dehydrogenase (class II), pi polypeptide
            MIM: 600086  Alcohol dehydrogenase-7
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
            PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
STRUCTURES  PDB: 1A4U  1A71  1A72  1ADB  1ADC  1ADF  1ADG  1AGN  1AXE  1AXG  
                 1B14  1B15  1B16  1B2L  1BTO  1CDO  1D1S  1D1T  1DDA  1DEH  
                 1E3E  1E3I  1E3L  1EE2  1HDX  1HDY  1HDZ  1HET  1HEU  1HF3  
                 1HLD  1HSO  1HSZ  1HT0  1HTB  1JU9  1LDE  1LDY  1QLH  1QLJ  
                 1TEH  2OHX  2OXI  3BTO  3HUD  5ADH  6ADH  7ADH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.1
            ExPASy - ENZYME nomenclature database: 1.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.1
            BRENDA, the Enzyme Database: 1.1.1.1
            SCOP (Structural Classification of Proteins): 1.1.1.1
///
ENTRY       EC 1.1.1.2
NAME        Alcohol dehydrogenase(NADP+)
            Aldehyde reductase(NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alcohol:NADP+ oxidoreductase
REACTION    Alcohol + NADP+ = Aldehyde + NADPH
SUBSTRATE   NADP+
            Primary alcohol
            Secondary alcohol
PRODUCT     Aldehyde
            NADPH
COFACTOR    Zinc
COMMENT     A zinc protein. Some members of this group oxidize only primary
            alcohols; others act also on secondary alcohols. May be identical
            with EC 1.1.1.19, 1.1.1.33 and 1.1.1.55. A-specific with respect
            to NADPH.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00930  Caprolactam degradation
GENES       XFA: XF1136 XF1727 XF1734
            PAE: PA2275
            HPY: HP1104
            HPJ: jhp1030 jhp1429
            CJE: Cj1548c
            BSU: BG12562(adhA)
            MPN: H03_orf351(adh)
            MTU: Rv3045(adhC)
            MTC: MT3130
            MLE: ML1730(adhA)
            SYN: slr0942
            MMU: 104906(Aldr1) 105041(Aldr3)
            HSA: 10327(AKR1A1)
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
            PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
STRUCTURES  PDB: 1AE4  1CWN  2ALR  1YKF  1PED  1KEV  1HQT  1C9W  1BXZ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.2
            ExPASy - ENZYME nomenclature database: 1.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.2
            BRENDA, the Enzyme Database: 1.1.1.2
            SCOP (Structural Classification of Proteins): 1.1.1.2
///
ENTRY       EC 1.1.1.3
NAME        Homoserine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Homoserine:NAD(P)+ oxidoreductase
REACTION    L-Homoserine + NAD+ or NADP+ = L-Aspartate 4-semialdehyde +
            NADH or NADPH
SUBSTRATE   L-Homoserine
            NAD+
            NADP+
PRODUCT     L-Aspartate 4-semialdehyde
            NADH
            NADPH
COMMENT     The yeast enzyme acts most rapidly with NAD+; the Neurospora
            enzyme with NADP+. The enzyme from E. coli is a multi-functional
            protein, which also catalyses the reaction of EC 2.7.2.4.
            (EC 2.7.2.4 Aspartate kinase)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b0002(thrA) b3940(metL)
            ECE: Z0002(thrA) Z5495(metL)
            ECS: ECs0002 ECs4869
            YPE: YPO0116(metL)
            HIN: HI0089(thrA)
            PMU: PM0113(thrA)
            XFA: XF2225
            VCH: VC2364 VC2684
            PAE: PA3736(hom)
            BUC: BU194(thrA)
            NME: NMB1228
            NMA: NMA1395(hom)
            HPY: HP0822(hom)
            HPJ: jhp0761
            CJE: Cj0149c(hom)
            MLO: mll0934
            SME: SMc00293(thrA)
            CCR: CC1383
            BSU: BG10460(hom)
            BHA: BH1253 BH1737 BH3422(hom)
            SAU: SA1164(dhoM)
            SAV: SAV1313(dhoM)
            LLA: L0090(hom)
            SPN: SP1361
            SPR: spr1219(hom)
            CAC: CAC0998
            MTU: Rv1294(thrA)
            MTC: MT1333
            MLE: ML1129(hom)
            SYN: sll0455(thrA)
            DRA: DR1278
            AAE: aq_1812(thrA)
            TMA: TM0547
            MJA: MJ1602(hom)
            MTH: MTH1232 MTH417
            AFU: AF0935(hom)
            HAL: VNG2650G(hom)
            TAC: Ta1179
            TVO: TVG0375766
            PHO: PH1075
            PAB: PAB0610(hom)
            APE: APE1144
            SSO: SSO0657(thrA/hom)
            SCE: YJR139C(HOM6)
            SPO: SPBC776.03(spbc776.03)
MOTIF       PS: PS00324  [LIVM]-x-K-[FY]-G-G-[ST]-[SC]-[LIVM]
            PS: PS01042  A-x(3)-G-[LIVMFY]-[STAG]-x(2,3)-[DNS]-P-x(2)-D-[LIVM]-
                         x-G-x-D-x(3)-K
STRUCTURES  PDB: 1EBU  1EBF  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.3
            ExPASy - ENZYME nomenclature database: 1.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.3
            BRENDA, the Enzyme Database: 1.1.1.3
            SCOP (Structural Classification of Proteins): 1.1.1.3
///
ENTRY       EC 1.1.1.4
NAME        (R,R)-Butanediol dehydrogenase
            Butyleneglycol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R,R)-Butane-2,3-diol:NAD+ oxidoreductase
REACTION    (R,R)-Butane-2,3-diol + NAD+ = (R)-Acetoin + NADH
SUBSTRATE   (R,R)-Butane-2,3-diol
            NAD+
            Diacetyl
            NADH
PRODUCT     (R)-Acetoin
            NADH
            NAD+
COMMENT     Also converts diacetyl into acetoin with NADH as reductant.
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.4
            ExPASy - ENZYME nomenclature database: 1.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.4
            BRENDA, the Enzyme Database: 1.1.1.4
///
ENTRY       EC 1.1.1.5
NAME        Acetoin dehydrogenase
            Diacetyl reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acetoin:NAD+ oxidoreductase
REACTION    Acetoin + NAD+ = Diacetyl + NADH
SUBSTRATE   Acetoin
            NAD+
            NADP+
PRODUCT     Diacetyl
            NADH
            NADPH
COMMENT     NADP+ also acts.
PATHWAY     PATH: MAP00650  Butanoate metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1GEG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.5
            ExPASy - ENZYME nomenclature database: 1.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.5
            BRENDA, the Enzyme Database: 1.1.1.5
            SCOP (Structural Classification of Proteins): 1.1.1.5
///
ENTRY       EC 1.1.1.6
NAME        Glycerol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycerol:NAD+ oxidoreductase
REACTION    Glycerol + NAD+ = Glycerone + NADH
SUBSTRATE   Glycerol
            NAD+
            Propane-1,2-diol
PRODUCT     Glycerone
            NADH
            Hydroxyacetone
COMMENT     Also acts on propane-1,2-diol.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b3945(gldA)
            ECE: Z5500(gldA)
            ECS: ECs4874
            SME: SMc02038(gldA)
            SPY: SPy2047(gldA)
            SPN: SP0253
            SPR: spr0234(gldA)
            SYN: slr1167(gldA)
            TMA: TM0423
            MJA: MJ0712
            MTH: MTH610
            AFU: AF1674(gldA)
            HAL: VNG0406C VNG6270G(gldA)
            TAC: Ta1158
            TVO: TVG1288826
            PHO: PH1475
            PAB: PAB1907
            APE: APE0519
            SSO: SSO0760(gldA)
            STO: ST0344
            SPO: SPAC13F5.03C(spac13f5.03c)
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
STRUCTURES  PDB: 1JQA  1JQ5  1JPU  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.6
            ExPASy - ENZYME nomenclature database: 1.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.6
            BRENDA, the Enzyme Database: 1.1.1.6
///
ENTRY       EC 1.1.1.7
NAME        Propanediol-phosphate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Propane-1,2-diol-1-phosphate:NAD+ oxidoreductase
REACTION    Propane-1,2-diol 1-phosphate + NAD+ = Hydroxyacetone phosphate +
            NADH
SUBSTRATE   Propane-1,2-diol 1-phosphate
            NAD+
PRODUCT     Hydroxyacetone phosphate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.7
            ExPASy - ENZYME nomenclature database: 1.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.7
            BRENDA, the Enzyme Database: 1.1.1.7
///
ENTRY       EC 1.1.1.8
NAME        Glycerol-3-phosphate dehydrogenase(NAD+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + NAD+ = Glycerone phosphate + NADH
SUBSTRATE   sn-Glycerol 3-phosphate
            NAD+
            Propane-1,2-diol 1-phosphate
            Glycerone sulfate
PRODUCT     Glycerone phosphate
            NADH
            Hydroxyacetone phosphate
COMMENT     Also acts on propane-1,2-diol phosphate and glycerone sulfate
            (but with a much lower affinity).
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       YPE: YPO0068(gpsA)
            SME: SMc03229(gpsA)
            MPU: MYPU_1240(gpsA)
            UUR: UU382(gpsA)
            TPA: TP1009
            SCE: YDL022W(GPD1) YOL059W(GPD2)
            SPO: GPD1_1(gpd1) GPD1_3(gpd1) GPD2(gpd2)
            CEL: F47G4.3 K11H3.1
            DME: CG3215 CG9042(Gpdh)
            MMU: 1098252(Daq12) 95679(Gdc1)
            HSA: 2819(GPD1)
DISEASE     MIM: 138420  Glycerol-3-phosphate dehydrogenase, soluble
MOTIF       PS: PS00957  G-[ATIV]-[LIVMYC]-K-[DN]-[LIVM]-[LIVMFY]-[GA]-x-[GA]-x-
                         G-[LIVMF]-x(2)-[SGA]-[LIVM]-x-[LIVMFYW]-G-x-N
STRUCTURES  PDB: 1EVZ  1EVY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.8
            ExPASy - ENZYME nomenclature database: 1.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.8
            BRENDA, the Enzyme Database: 1.1.1.8
            SCOP (Structural Classification of Proteins): 1.1.1.8
///
ENTRY       EC 1.1.1.9
NAME        D-Xylulose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Xylitol:NAD+ 2-oxidoreductase (D-xylulose-forming)
REACTION    Xylitol + NAD+ = D-Xylulose + NADH
SUBSTRATE   Xylitol
            NAD+
            Erythritol
PRODUCT     D-Xylulose
            NADH
            L-Erythrulose
COMMENT     Also acts as an L-erythrulose reductase.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.9
            ExPASy - ENZYME nomenclature database: 1.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.9
            BRENDA, the Enzyme Database: 1.1.1.9
///
ENTRY       EC 1.1.1.10
NAME        L-Xylulose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Xylitol:NADP+ 4-oxidoreductase (L-xylulose-forming)
REACTION    Xylitol + NADP+ = L-Xylulose + NADPH
SUBSTRATE   Xylitol
            NADP+
PRODUCT     L-Xylulose
            NADPH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.10
            ExPASy - ENZYME nomenclature database: 1.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.10
            BRENDA, the Enzyme Database: 1.1.1.10
///
ENTRY       EC 1.1.1.11
NAME        D-Arabinitol 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Arabinitol:NAD+ 4-oxidoreductase
REACTION    D-Arabinitol + NAD+ = D-Xylulose + NADH
SUBSTRATE   D-Arabinitol
            NAD+
PRODUCT     D-Xylulose
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.11
            ExPASy - ENZYME nomenclature database: 1.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.11
            BRENDA, the Enzyme Database: 1.1.1.11
///
ENTRY       EC 1.1.1.12
NAME        L-Arabinitol 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Arabinitol:NAD+ 4-oxidoreductase (L-xylulose-forming)
REACTION    L-Arabinitol + NAD+ = L-Xylulose + NADH
SUBSTRATE   L-Arabinitol
            NAD+
PRODUCT     L-Xylulose
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.12
            ExPASy - ENZYME nomenclature database: 1.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.12
            BRENDA, the Enzyme Database: 1.1.1.12
///
ENTRY       EC 1.1.1.13
NAME        L-Arabinitol 2-dehydrogenase
            L-Arabinitol dehydrogenase (ribulose-forming)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Arabinitol:NAD+ 2-oxidoreductase (L-ribulose-forming)
REACTION    L-Arabinitol + NAD+ = L-Ribulose + NADH
SUBSTRATE   L-Arabinitol
            NAD+
PRODUCT     L-Ribulose
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.13
            ExPASy - ENZYME nomenclature database: 1.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.13
            BRENDA, the Enzyme Database: 1.1.1.13
///
ENTRY       EC 1.1.1.14
NAME        L-Iditol 2-dehydrogenase
            Polyol dehydrogenase
            Sorbitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Iditol:NAD+ 2-oxidoreductase
REACTION    L-Iditol + NAD+ = L-Sorbose + NADH
SUBSTRATE   L-Iditol
            NAD+
            D-Glucitol
PRODUCT     L-Sorbose
            NADH
            D-Fructose
COMMENT     Also acts on D-glucitol (giving D-fructose) and other
            closely related sugar alcohols
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       YPE: YPO2502(gutB)
            PAE: PA4153
            MLO: mlr3340
            SME: SMc01500(smoS)
            BSU: BG10177(gutB)
            BHA: BH0187(gutB) BH0189
            SAU: SA0239 SA0240
            SAV: SAV0241(gutB) SAV0243
            SSO: SSO3237
            SCE: YJR159W(SOR1)
            SPO: TMS1(tms1)
            CEL: R04B5.5 R04B5.6
            DME: CG1982(Sodh-1) CG4649(Sodh-2)
            MMU: 98266(Sdh1)
            HSA: 6652(SORD)
DISEASE     MIM: 182500  Sorbitol dehydrogenase
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
            PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1SDG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.14
            ExPASy - ENZYME nomenclature database: 1.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.14
            BRENDA, the Enzyme Database: 1.1.1.14
            SCOP (Structural Classification of Proteins): 1.1.1.14
///
ENTRY       EC 1.1.1.15
NAME        D-Iditol 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Iditol:NAD+ 2-oxidoreductase
REACTION    D-Iditol + NAD+ = D-Sorbose + NADH
SUBSTRATE   D-Iditol
            NAD+
            Xylitol
            L-Glucitol
PRODUCT     D-Sorbose
            NADH
            L-Xylulose
            L-Fructose
COMMENT     Also converts xylitol into L-xylulose and L-glucitol into
            L-fructose.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.15
            ExPASy - ENZYME nomenclature database: 1.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.15
            BRENDA, the Enzyme Database: 1.1.1.15
///
ENTRY       EC 1.1.1.16
NAME        Galactitol 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Galactitol:NAD+ 2-oxidoreductase
REACTION    Galactitol + NAD+ = D-Tagatose + NADH
SUBSTRATE   Galactitol
            NAD+
PRODUCT     D-Tagatose
            NADH
COMMENT     Also converts other alditols containing an L-threo-configuration
            adjacent to a primary alcohol group into the corresponding sugars.
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.16
            ExPASy - ENZYME nomenclature database: 1.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.16
            BRENDA, the Enzyme Database: 1.1.1.16
///
ENTRY       EC 1.1.1.17
NAME        Mannitol-1-phosphate 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannitol-1-phosphate:NAD+ 5-oxidoreductase
REACTION    D-Mannitol 1-phosphate + NAD+ = D-Fructose 6-phosphate + NADH
SUBSTRATE   D-Mannitol 1-phosphate
            NAD+
PRODUCT     D-Fructose 6-phosphate
            NADH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b3600(mtlD)
            ECE: Z5024(mtlD)
            ECS: ECs4476
            YPE: YPO4067(mtlD)
            PMU: PM1062(mtlD)
            VCH: VCA1046
            BUC: BU571(mtlD)
            BSU: BG11216(mtlD)
            BHA: BH3851(mtlD)
            SAU: SA1963(mtlD)
            SAV: SAV2145(mtlD)
            LLA: L33416(mtlD)
            SPN: SP0397
            SPR: spr0359(mtlD)
            CAC: CAC0157(MtlD)
            MPN: E09_orf364(mtlD)
            MPU: MYPU_7500(mtlD)
MOTIF       PS: PS00974  [LIVMY]-x-[FS]-x(2)-[STAGCV]-x-V-D-R-[IV]-x-[PS]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.17
            ExPASy - ENZYME nomenclature database: 1.1.1.17
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.17
            BRENDA, the Enzyme Database: 1.1.1.17
///
ENTRY       EC 1.1.1.18
NAME        myo-Inositol 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     myo-Inositol:NAD+ 2-oxidoreductase
REACTION    myo-Inositol + NAD+ = 2,4,6/3,5-Pentahydroxycyclohexanone + NADH
SUBSTRATE   myo-Inositol
            NAD+
PRODUCT     2,4,6/3,5-Pentahydroxycyclohexanone
            NADH
PATHWAY     PATH: MAP00031  Inositol metabolism
            PATH: MAP00562  Inositol phosphate metabolism
GENES       SME: SMb20899(idhA)
            BSU: BG10669(iolG)
            BHA: BH2316(iolG)
            MTH: MTH875
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.18
            ExPASy - ENZYME nomenclature database: 1.1.1.18
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.18
            BRENDA, the Enzyme Database: 1.1.1.18
///
ENTRY       EC 1.1.1.19
NAME        Glucuronate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Gulonate:NADP+ 6-oxidoreductase
REACTION    L-Gulonate + NADP+ = D-Glucuronate + NADPH
SUBSTRATE   L-Gulonate
            NADP+
PRODUCT     D-Glucuronate
            NADPH
            D-Galacturonate
COMMENT     Also reduces D-galacturonate. May be identical with EC 1.1.1.2.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.19
            ExPASy - ENZYME nomenclature database: 1.1.1.19
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.19
            BRENDA, the Enzyme Database: 1.1.1.19
///
ENTRY       EC 1.1.1.20
NAME        Glucuronolactone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Gulono-1,4-lactone:NADP+ 1-oxidoreductase
REACTION    L-Gulono-1,4-lactone + NADP+ = D-Glucurono-3,6-lactone + NADPH
SUBSTRATE   L-Gulono-1,4-lactone
            NADP+
PRODUCT     D-Glucurono-3,6-lactone
            NADPH
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.20
            ExPASy - ENZYME nomenclature database: 1.1.1.20
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.20
            BRENDA, the Enzyme Database: 1.1.1.20
///
ENTRY       EC 1.1.1.21
NAME        Aldehyde reductase
            Aldose reductase
            Polyol dehydrogenase(NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alditol:NAD(P)+ 1-oxidoreductase
REACTION    Alditol + NAD+ or NADP+ = Aldose + NADH or NADPH
SUBSTRATE   Alditol
            NAD+
            NADP+
PRODUCT     Aldose
            NADH
            NADPH
INHIBITOR   Tolrestat
            HOE-252
            Zopolrestat
            Salfredin
COMMENT     Wide specificity.
            Inhibited by zopolrestat. This structure was determined to 1.8 A
            resolution (Proc.Natl.Acad.Sci.USA 90 9847-51(1993)).
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0207(yafB)
            ECE: Z0229(yafB)
            ECS: ECs0203
            BBU: BB0528
            CEL: T08H10.1
            DME: CG6084
            MMU: 101918(Avdp) 104906(Aldr1)
            HSA: 231(AKR1B1)
DISEASE     MIM: 103880  Aldo-keto reductase family 1, member B1
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
STRUCTURES  PDB: 1MAR  2ACQ  2ACR  2ACS  2ACU  1EF3  1EKO  1EL3  1DLA  1AZ2  
                 1ABN  1ADS  1AH0  1AH3  1AH4  1AZ1  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.21
            ExPASy - ENZYME nomenclature database: 1.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.21
            BRENDA, the Enzyme Database: 1.1.1.21
            SCOP (Structural Classification of Proteins): 1.1.1.21
///
ENTRY       EC 1.1.1.22
NAME        UDPglucose 6-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     UDPglucose:NAD+ oxidoreductase
REACTION    UDPglucose + 2 NAD+ + H2O = UDPglucuronate + 2 NADH
SUBSTRATE   UDPglucose
            NAD+
            H2O
            UDP-2-deoxyglucose
PRODUCT     UDPglucuronate
            NADH
COMMENT     Also acts on UDP-2-deoxyglucose.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b2028(ugd)
            ECE: Z3190(ugd)
            ECS: ECs2829
            PMU: PM0776
            XFA: XF1606
            VCH: VCA0780
            PAE: PA2022 PA3559
            CJE: Cj1441c(kfiD)
            RPR: RP779(udg)
            MLO: mlr5265
            SME: SMc02641(rkpK)
            CCR: CC2379 CC2382
            BSU: BG12691(tuaD)
            BHA: BH3708
            SPY: SPy0542 SPy2201(hasB)
            SPR: spr0139(ugd) spr0318(cps2K)
            MTU: Rv0322(udgA)
            MTC: MT0337
            SYN: slr1299
            AAE: aq_024(nsd)
            MJA: MJ1054
            AFU: AF0302(ugd-1) AF0596(ugd-2)
            HAL: VNG0046G(ugd)
            PAB: PAB0770(ugd)
            SSO: SSO0810(ugd)
            CEL: F29F11.1
            DME: CG10072(sgl)
            HSA: 7358(UGDH)
STRUCTURES  PDB: 1DLJ  1DLI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.22
            ExPASy - ENZYME nomenclature database: 1.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.22
            BRENDA, the Enzyme Database: 1.1.1.22
            SCOP (Structural Classification of Proteins): 1.1.1.22
///
ENTRY       EC 1.1.1.23
NAME        Histidinol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Histidinol:NAD+ oxidoreductase
REACTION    L-Histidinol + 2 NAD+ = L-Histidine + 2 NADH
SUBSTRATE   L-Histidinol
            L-Histidinal
            NAD+
PRODUCT     L-Histidine
            NADH
COMMENT     Also oxidizes L-histidinal. The Neurospora enzyme also catalyses
            the reaction of EC 3.5.4.19 and 3.6.1.31.
            (EC 3.5.4.19 Phosphoribosyl-AMP cyclohydrolase)
            (EC 3.6.1.31 Phosphoribosyl-ATP pyrophosphatase)
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2020(hisD)
            ECE: Z3182(hisD)
            ECS: ECs2821
            YPE: YPO1548(hisD)
            HIN: HI0469(hisD)
            PMU: PM1198(hisD)
            XFA: XF2219
            VCH: VC1133
            PAE: PA4448(hisD)
            BUC: BU100(hisD)
            NME: NMB1581
            NMA: NMA1770(hisD)
            CJE: Cj1598(hisD)
            MLO: mll6456 mlr6649 mlr7107
            SME: SMa0398(hisD2) SMc02307(hisD1)
            CCR: CC2346
            BSU: BG12599(hisD)
            BHA: BH3582(hisD)
            SAU: SA2470
            SAV: SAV2663(hisD)
            LLA: L0067(hisD)
            CAC: CAC0937(hisD)
            MTU: Rv1599(hisD)
            MTC: MT1635
            MLE: ML1257(hisD)
            SYN: slr0682(hisD) slr1848(hisD)
            DRA: DR2140
            AAE: aq_782(hisD)
            TMA: TM1041
            MJA: MJ1456(hisD)
            MTH: MTH225
            AFU: AF0212(hisD)
            HAL: VNG1444G(hisD)
            SSO: SSO0599(hisD)
            SCE: YCL030C(HIS4)
MOTIF       PS: PS00611  I-D-x(2)-A-G-P-[ST]-E-[LIVS]-[LIVMA](3)-[AC]-x(3)-A-
                         x(4)-[LIVM]-[AV]-[SACL]-[DE]-[LIVMFC]-[LIVM]-[SA]-x(2)-
                         E-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.23
            ExPASy - ENZYME nomenclature database: 1.1.1.23
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.23
            BRENDA, the Enzyme Database: 1.1.1.23
///
ENTRY       EC 1.1.1.24
NAME        Quinate 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Quinate:NAD+ 5-oxidoreductase
REACTION    Quinate + NAD+ = 5-Dehydroquinate + NADH
SUBSTRATE   Quinate
            NAD+
PRODUCT     5-Dehydroquinate
            NADH
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.24
            ExPASy - ENZYME nomenclature database: 1.1.1.24
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.24
            BRENDA, the Enzyme Database: 1.1.1.24
///
ENTRY       EC 1.1.1.25
NAME        Shikimate 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Shikimate:NADP+ 5-oxidoreductase
REACTION    Shikimate + NADP+ = 5-Dehydroshikimate + NADPH
SUBSTRATE   Shikimate
            NADP+
PRODUCT     5-Dehydroshikimate
            NADPH
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b3281(aroE)
            ECE: Z4652(aroE)
            ECS: ECs4147
            YPE: YPO0246(aroE)
            HIN: HI0655(aroE)
            PMU: PM1271(aroE)
            XFA: XF0624
            VCH: VC0056
            PAE: PA0025(aroE) PA0244
            BUC: BU493(aroE)
            NME: NMB0358
            NMA: NMA2129(aroE)
            HPY: HP1249(aroE)
            HPJ: jhp1170
            CJE: Cj0405(aroE)
            MLO: mlr4492
            SME: SMb20037(aroE2) SMc02791(aroE1)
            CCR: CC0003
            BSU: BG11522(aroD)
            BHA: BH1324(aroD)
            SAU: SA1424(aroE)
            SAV: SAV1584(aroE)
            LLA: L0061(aroE)
            SPY: SPy0534(aroE.2) SPy1584(aroE)
            SPN: SP1376
            SPR: spr1234(aroE)
            CAC: CAC0897(aro)
            MTU: Rv2552c(aroE)
            MTC: MT2629
            MLE: ML0515(aroE)
            CTR: CT370
            CMU: TC0649
            CPN: CPn1035
            CPA: CP0817
            CPJ: aroE
            SYN: slr1559(aroE)
            DRA: DR0077 DR1173
            AAE: aq_901(aroE)
            TMA: TM0346
            MJA: MJ1084(aroE)
            MTH: MTH242
            AFU: AF2327(aroE)
            HAL: VNG0382G(aroE)
            TAC: Ta0284
            TVO: TVG1385100
            PAB: PAB0300(aroE)
            APE: APE0574
            SSO: SSO0306(aroE)
            SCE: YDR127W(ARO1)
MOTIF       PS: PS00104  [LIVF]-x(2)-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-x-R-
                         x-[LIVMFYAT]-x-[GSTAP]
            PS: PS00885  [KR]-x-[KH]-E-[CST]-[DNE]-R-[LIVM]-x-[GSTAV]-[LIVMCT]-
                         x(3)-[LIVMF]-x(2)-[LIVMFCGAN]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-
                         H-[DN]
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMFG]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.25
            ExPASy - ENZYME nomenclature database: 1.1.1.25
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.25
            BRENDA, the Enzyme Database: 1.1.1.25
///
ENTRY       EC 1.1.1.26
NAME        Glyoxylate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycolate:NAD+ oxidoreductase
REACTION    Glycolate + NAD+ = Glyoxylate + NADH
SUBSTRATE   Glycolate
            NAD+
            D-Glycerate
PRODUCT     Glyoxylate
            Hydroxypyruvate
            NADH
COMMENT     Reduces glyoxylate to glycolate or hydroxypyruvate to D-glycerate.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.26
            ExPASy - ENZYME nomenclature database: 1.1.1.26
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.26
            BRENDA, the Enzyme Database: 1.1.1.26
///
ENTRY       EC 1.1.1.27
NAME        L-Lactate dehydrogenase
            Lactic acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Lactate:NAD+ oxidoreductase
REACTION    (S)-Lactate + NAD+ = Pyruvate + NADH
SUBSTRATE   (S)-Lactate
            (S)-2-Hydroxymonocarboxylic acid
            NAD+
PRODUCT     Pyruvate
            NADH
COMMENT     Also oxidizes other (S)-2-hydroxy-monocarboxylic acids.
            NADP+ also acts, more slowly, with the animal, but not the
            bacterial, enzyme.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       CJE: Cj1167(ldh)
            BSU: BG19003(ldh)
            BHA: BH3937(lctE)
            SAU: SA0232(lctE) SA2395
            SAV: SAV0234(ldh) SAV2586(lctE)
            LLA: L0017(ldh) L0018(ldhB) L142159(ldhX)
            SPY: SPy1151(ldh)
            SPN: SP1220
            SPR: spr1100(ldh)
            CAC: CAC0267 CAC3552
            MGE: MG460(ldh)
            MPN: K05_orf312(ldh)
            MPU: MYPU_7590(ldh)
            BBU: BB0087(ldh)
            DRA: DR2364
            TMA: TM1867
            SSO: SSO2585(sqdB)
            SPO: SPAC186.08C(spac186.08c)
            ATH: At4g17260(dl4665w)
            CEL: F13D12.2
            DME: CG10160 CG13334
            MMU: 96759(Ldh1) 96763(Ldh2) 96764(Ldh3)
            HSA: 3939(LDHA) 3945(LDHB) 3948(LDHC)
DISEASE     MIM: 150000  Lactate dehydrogenase A
            MIM: 150100  Lactate dehydrogenase B
            MIM: 150150  Lactate dehydrogenase C
MOTIF       PS: PS00064  [LIVMA]-G-[EQ]-H-G-[DN]-[ST]
STRUCTURES  PDB: 6LDH  1A5Z  9LDT  5LDH  3LDH  2LDX  2LDB  1LTH  1LLD  1LLC  
                 9LDB  1LDN  1LDM  1I10  8LDH  1LDG  1LDB  1I0Z  1HYH  1HYG  
                 1CEQ  1CET  1HYE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.27
            ExPASy - ENZYME nomenclature database: 1.1.1.27
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.27
            BRENDA, the Enzyme Database: 1.1.1.27
            SCOP (Structural Classification of Proteins): 1.1.1.27
///
ENTRY       EC 1.1.1.28
NAME        D-Lactate dehydrogenase
            Lactic acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Lactate:NAD+ oxidoreductase
REACTION    (R)-Lactate + NAD+ = Pyruvate + NADH
SUBSTRATE   (R)-Lactate
            NAD+
PRODUCT     Pyruvate
            NADH
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b1380(ldhA) b2133(dld)
            ECE: Z2329(ldhA) Z3382(dld)
            ECS: ECs2002 ECs3020
            YPE: YPO1177(dld) YPO2329(ldhA)
            HIN: HI0085 HI1649(dld)
            XFA: XF0347
            VCH: VCA0192
            PAE: PA0927(ldhA)
            NME: NMB0997 NMB1685
            NMA: NMA1205(dld) NMA1944(ldhA)
            SAV: SAV2507(ddh)
            SPY: SPy1170(ddh)
            CAC: CAC1543 CAC2691
            TPA: TP0037
            SYN: slr1556(ddh)
            AAE: aq_1769(dld1) aq_727(ldhA)
MOTIF       PS: PS00065  [LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-
                         G-x(13,14)-[LIVMFT]-x(2)-[FYWCTH]-[DNSTK]
            PS: PS00670  [LIVMFYWA]-[LIVFYWC]-x(2)-[SAC]-[DNQHR]-[IVFA]-[LIVF]-
                         x-[LIVF]-[HNI]-x-P-x(4)-[STN]-x(2)-[LIVMF]-x-[GSDN]
            PS: PS00671  [LMFATC]-[KPQ]-x-[GSTDN]-x-[LIVMFYWR]-[LIVMFYW](2)-N-x-
                         [STAGC]-R-[GP]-x-[LIVH]-[LIVMC]-[DNV]
STRUCTURES  PDB: 1DLD  2DLD  1F0X  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.28
            ExPASy - ENZYME nomenclature database: 1.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.28
            BRENDA, the Enzyme Database: 1.1.1.28
            SCOP (Structural Classification of Proteins): 1.1.1.28
///
ENTRY       EC 1.1.1.29
NAME        Glycerate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Glycerate:NAD+ oxidoreductase
REACTION    (R)-Glycerate + NAD+ = Hydroxypyruvate + NADH
SUBSTRATE   (R)-Glycerate
            NAD+
PRODUCT     Hydroxypyruvate
            NADH
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       PAE: PA4626(hprA)
            NME: NMB0029
            NMA: NMA0274
            CAC: CAC2945
            HSA: 2758(GLYD)
MOTIF       PS: PS00065  [LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-
                         G-x(13,14)-[LIVMFT]-x(2)-[FYWCTH]-[DNSTK]
            PS: PS00670  [LIVMFYWA]-[LIVFYWC]-x(2)-[SAC]-[DNQHR]-[IVFA]-[LIVF]-
                         x-[LIVF]-[HNI]-x-P-x(4)-[STN]-x(2)-[LIVMF]-x-[GSDN]
            PS: PS00671  [LMFATC]-[KPQ]-x-[GSTDN]-x-[LIVMFYWR]-[LIVMFYW](2)-N-x-
                         [STAGC]-R-[GP]-x-[LIVH]-[LIVMC]-[DNV]
STRUCTURES  PDB: 1GDH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.29
            ExPASy - ENZYME nomenclature database: 1.1.1.29
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.29
            BRENDA, the Enzyme Database: 1.1.1.29
            SCOP (Structural Classification of Proteins): 1.1.1.29
///
ENTRY       EC 1.1.1.30
NAME        3-Hydroxybutyrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
REACTION    (R)-3-Hydroxybutanoate + NAD+ = Acetoacetate + NADH
SUBSTRATE   (R)-3-Hydroxybutanoate
            NAD+
            3-Hydroxymonocarboxylic acid
PRODUCT     Acetoacetate
            NADH
COMMENT     Also oxidizes other 3-hydroxymonocarboxylic acids.
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00650  Butanoate metabolism
GENES       PAE: PA2003(bdhA)
            MLO: mll3632 mlr2400
            SME: SMb21010(bdhA)
            CCR: CC3384
            BSU: BG11155(bdh)
            HSA: 622(BDH)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.30
            ExPASy - ENZYME nomenclature database: 1.1.1.30
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.30
            BRENDA, the Enzyme Database: 1.1.1.30
///
ENTRY       EC 1.1.1.31
NAME        3-Hydroxyisobutyrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Hydroxy-2-methylpropanoate:NAD+ oxidoreductase
REACTION    3-Hydroxy-2-methylpropanoate + NAD+ =
            2-Methyl-3-oxopropanoate + NADH
SUBSTRATE   3-Hydroxy-2-methylpropanoate
            NAD+
PRODUCT     2-Methyl-3-oxopropanoate
            NADH
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
GENES       HIN: HI1010
            PMU: PM1366
            VCH: VCA0007
            PAE: PA0743 PA3312 PA3569(mmsB)
            NME: NMB1584
            NMA: NMA1773
            HPJ: jhp0585
            MLO: mlr0552 mlr1203 mlr2606
            SME: SMb20751
            CCR: CC1354
            BSU: BG12914(yfjR) BG13328(ykwC)
            BHA: BH2634
            LLA: L81616(ywjF)
            CAC: CAC3342
            MTU: Rv0751c(mmsB) Rv0770
            MTC: MT0775 MT0794
            SYN: slr0229(mmsB)
            DRA: DR0499
            AAE: aq_038(hibD)
            TAC: Ta0161
            TVO: TVG0242719
            APE: APE0756
            SSO: SSO0974 SSO1560
            STO: ST0619
            CEL: B0250.5
            DME: CG15093_1
MOTIF       PS: PS00895  [LIVMFY](2)-G-L-G-x-[MQ]-G-x(2)-[MA]-[SAV]-x-[SNHR]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.31
            ExPASy - ENZYME nomenclature database: 1.1.1.31
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.31
            BRENDA, the Enzyme Database: 1.1.1.31
///
ENTRY       EC 1.1.1.32
NAME        Mevaldate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Mevalonate:NAD+ oxidoreductase
REACTION    (R)-Mevalonate + NAD+ = Mevaldate + NADH
SUBSTRATE   (R)-Mevalonate
            NAD+
PRODUCT     Mevaldate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.32
            ExPASy - ENZYME nomenclature database: 1.1.1.32
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.32
            BRENDA, the Enzyme Database: 1.1.1.32
///
ENTRY       EC 1.1.1.33
NAME        Mevaldate reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Mevalonate:NADP+ oxidoreductase
REACTION    (R)-Mevalonate + NADP+ = Mevaldate + NADPH
SUBSTRATE   (R)-Mevalonate
            NADP+
PRODUCT     Mevaldate
            NADPH
COMMENT     May be identical with EC 1.1.1.2.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.33
            ExPASy - ENZYME nomenclature database: 1.1.1.33
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.33
            BRENDA, the Enzyme Database: 1.1.1.33
///
ENTRY       EC 1.1.1.34
NAME        Hydroxymethylglutaryl-CoA reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
REACTION    (R)-Mevalonate + CoA + 2 NADP+ =
            (S)-3-Hydroxy-3-methylglutaryl-CoA + 2 NADPH
SUBSTRATE   (R)-Mevalonate
            CoA
            NADP+
PRODUCT     (S)-3-Hydroxy-3-methylglutaryl-CoA
            NADPH
INHIBITOR   Pravastatin
COMMENT     The enzyme is inactivated by EC 2.7.1.109 and reactivated by
            EC 3.1.3.47.
            (EC 2.7.1.109 Hydroxymethylglutaryl-CoA reductase(NADPH) kinase)
            (EC 3.1.3.47 Hydroxymethylglutaryl-CoA reductase(NADPH)-
            phosphatase)
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       VCH: VCA0723
            SAU: SA2333(mvaA)
            SAV: SAV2528
            LLA: L10433(mvaA)
            SPY: SPy0880(mvaS.1)
            SPN: SP1726
            BBU: BB0685(mvaA)
            MJA: MJ0705(hmgA)
            MTH: MTH562
            AFU: AF1736(mvaA)
            HAL: VNG1875G(mvaA)
            TAC: Ta0406
            TVO: TVG1221182
            PHO: PH1805
            PAB: PAB2106(mvaA)
            APE: APE1869
            SSO: SSO0531
            STO: ST1352
            SCE: YLR450W(HMG2) YML075C(HMG1)
            SPO: HMG1(hmg1)
            ATH: At2g17370(F5J6.1)
            CEL: F08F8.2
            DME: CG10367(Hmgcr)
            HSA: 3156(HMGCR)
MOTIF       PS: PS00066  [RKH]-x(6)-D-x-M-G-x-N-x-[LIVMA]
            PS: PS00318  [LIVM]-G-x-[LIVM]-G-G-[AG]-T
            PS: PS01192  A-[LIVM]-x-[STAN]-x(2)-[LI]-x-[KRNQ]-[GSA]-H-[LM]-x-
                         [FYLH]
            PS: PS50065  Hydroxymethylglutaryl-coenzyme A reductases profile
STRUCTURES  PDB: 1HWJ  1HWL  1HWK  1HWI  1HW9  1HW8  1DQA  1DQ8  1DQ9  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.34
            ExPASy - ENZYME nomenclature database: 1.1.1.34
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.34
            BRENDA, the Enzyme Database: 1.1.1.34
            SCOP (Structural Classification of Proteins): 1.1.1.34
///
ENTRY       EC 1.1.1.35
NAME        3-Hydroxyacyl-CoA dehydrogenase
            beta-Hydroxyacyl dehydrogenase
            beta-Keto-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (3S)-3-Hydroxyacyl-CoA:NAD+ oxidoreductase
REACTION    (3S)-3-Hydroxyacyl-CoA + NAD+ = 3-Oxoacyl-CoA + NADH
SUBSTRATE   (3S)-3-Hydroxyacyl-CoA
            (3S)-3-Hydroxyacyl-N-acylthioethanolamine
            (3S)-3-Hydroxyacyl-hydrolipoate
            NAD+
            (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
PRODUCT     3-Oxoacyl-CoA
            NADH
            2-Methylacetoacetyl-CoA
COMMENT     Also oxidizes (S)-3-hydroxyacyl-N-acylthioethanolamine and
            (S)-3-hydroxyacyl-hydrolipoate. Some enzymes act, more slowly,
            with NADP+. Broad specificity to acyl chain-length
            (cf. EC 1.1.1.211).
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b2341 b3846(fadB)
            ECE: Z3604 Z5367(fadB)
            ECS: ECs3224 ECs4774
            VCH: VC1047 VC2758
            PAE: PA1737 PA2554 PA3014(faoA) PA5188 PA5386
            RPR: RP560(fadB)
            MLO: mll4199 mlr2803 mlr5041 mlr5629
            SME: SMb21632 SMc02227(fadB)
            CCR: CC0076 CC0124 CC3189
            BSU: BG14024(yusL)
            BHA: BH3488
            SAU: SA0224
            SAV: SAV0225(fadB)
            MTU: Rv0468(fadB2) Rv0860(fadB) Rv1144
            MTC: MT0484 MT0883 MT1177
            MLE: ML2161(fadB) ML2461(fadB2)
            DRA: DR1487 DRA0143
            AFU: AF0017(hbd-1) AF0285(hbd-2) AF0434(hbd-3) AF1025(hbd-4)
                 AF1122(hbd-5) AF1177(hbd-6) AF1190(hbd-7) AF1206(hbd-8)
                 AF2017(hbd-9) AF2273(hbd-10)
            HAL: VNG0681G(hbd1) VNG1313G(hbd2)
            TAC: Ta0291 Ta0476
            TVO: TVG0862758 TVG1375310
            APE: APE1484
            SSO: SSO2514
            STO: ST0069
            CEL: B0272.3 C29F3.1 F01G10.2 F01G10.3 F54C8.1 R09B5.6 T08B2.7
            DME: CG4389(BcDNA:GH12558) CG7113(scu)
            HSA: 1962(EHHADH) 3028(HADH2) 3030(HADHA) 3033(HADHSC)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00067  [DNE]-x(2)-[GA]-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-
                         [LIVMFY](2)-x(5)-[LIVMFYCT]-[LIVMFY]-x(2)-[GV]
            PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 2HDH  3HAD  3HDH  1F67  1F17  1F14  1E3S  1E3W  1F12  1F0Y  
                 1E6W  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.35
            ExPASy - ENZYME nomenclature database: 1.1.1.35
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.35
            BRENDA, the Enzyme Database: 1.1.1.35
            SCOP (Structural Classification of Proteins): 1.1.1.35
///
ENTRY       EC 1.1.1.36
NAME        Acetoacetyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-3-Hydroxyacyl-CoA:NADP+ oxidoreductase
REACTION    (3R)-3-Hydroxyacyl-CoA + NADP+ = 3-Oxoacyl-CoA + NADPH
SUBSTRATE   (3R)-3-Hydroxyacyl-CoA
            NADP+
PRODUCT     3-Oxoacyl-CoA
            NADPH
PATHWAY     PATH: MAP00650  Butanoate metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.36
            ExPASy - ENZYME nomenclature database: 1.1.1.36
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.36
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.36
            BRENDA, the Enzyme Database: 1.1.1.36
///
ENTRY       EC 1.1.1.37
NAME        Malate dehydrogenase
            Malic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Malate:NAD+ oxidoreductase
REACTION    (S)-Malate + NAD+ = Oxaloacetate + NADH
SUBSTRATE   (S)-Malate
            2-Hydroxydicarboxylic acid
            NAD+
PRODUCT     Oxaloacetate
            NADH
COMMENT     Also oxidizes some other 2-hydroxydicarboxylic acids.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00710  Carbon fixation
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b0517(ylbC) b0801(ybiC) b3236(mdh) b3575(yiaK)
            ECE: Z0672(ylbC) Z1022(ybiC) Z4595(mdh)
            ECS: ECs0579 ECs0879 ECs4109
            HIN: HI1031 HI1210(mdh)
            PMU: PM0550(mdh_2) PM1256
            XFA: XF1211
            VCH: VC0432
            PAE: PA1252
            CJE: Cj0532(mdh)
            RPR: RP376(mdh)
            RCO: RC0520(mdh)
            MLO: mll4308 mll5197 mlr9117 mlr9216
            SME: SMc02479(mdh)
            CCR: CC3655
            BSU: BG11386(mdh) BG13206(yjmC)
            BHA: BH3158(citH)
            CAC: CAC0566
            MTU: Rv1240(mdh)
            MTC: MT1278
            MLE: ML1091(mdh)
            CTR: CT376
            CMU: TC0655
            CPN: CPn1028
            CPA: CP0824
            CPJ: mdhC
            SYN: sll0891(citH)
            DRA: DR0325
            AAE: aq_1665(mdh2) aq_1782(mdh1)
            MJA: MJ0490(ldh) MJ1425(mdh)
            MTH: MTH1205 MTH188
            AFU: AF0855(mdhA)
            HAL: VNG2367G(mdhA)
            TAC: Ta0952
            TVO: TVG1151701
            PHO: PH1277
            PAB: PAB1791
            APE: APE0672
            SCE: YDL078C(MDH3) YKL085W(MDH1) YOL126C(MDH2)
            SPO: SPCC306.08C(spcc306.08c)
            CEL: F20H11.3
            DME: CG10748 CG10749 CG5362 CG7998
            MMU: 97050(Mor1) 97051(Mor2)
            HSA: 4190(MDH1) 4191(MDH2)
DISEASE     MIM: 154100  Malate dehydrogenase, mitochondrial
            MIM: 154200  Malate dehydrogenase, soluble
MOTIF       PS: PS00068  [LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1CME  1D3A  1EMD  1HLP  1HR9  1IE3  1BMD  2CMD  2HLP  5MDH  
                 1BDM  1MLD  4MDH  1IB6  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.37
            ExPASy - ENZYME nomenclature database: 1.1.1.37
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.37
            BRENDA, the Enzyme Database: 1.1.1.37
            SCOP (Structural Classification of Proteins): 1.1.1.37
///
ENTRY       EC 1.1.1.38
NAME        Malate dehydrogenase (oxaloacetate-decarboxylating)
            'Malic' enzyme
            Pyruvic-malic carboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Malate:NAD+ oxidoreductase
            (oxaloacetate-decarboxylating)
REACTION    (S)-Malate + NAD+ = Pyruvate + CO2 + NADH
SUBSTRATE   (S)-Malate
            NAD+
            Oxaloacetate
PRODUCT     Pyruvate
            CO2
            NADH
COMMENT     Also decarboxylates added oxaloacetate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b1479(sfcA)
            ECE: Z2231(sfcA)
            ECS: ECs2083
            YPE: YPO1511(sfcA)
            VCH: VC1188 VC2681
            PAE: PA3471 PA5046
            NME: NMB0671(NAD)
            NMA: NMA0870(maeA)
            CJE: Cj1287c
            RCO: RC0507(tme)
            BSU: BG11312(ywkA) BG11764(yqkJ) BG12614(malS) BG13922(ytsJ)
            BHA: BH0399 BH3168
            SAU: SA1524
            SAV: SAV1688
            LLA: L121483(mleS) L3227(mae)
            CAC: CAC1589(malS) CAC1596(malS)
            MTU: Rv2332(mez)
            MTC: MT2394
            SYN: slr0721
            DRA: DR2583 DRA0276
            TMA: TM0542
            AFU: AF1727(mae)
            TAC: Ta0456
            TVO: TVG0785282
            PHO: PH1275
            PAB: PAB1792(mae)
            APE: APE0392
            SSO: SSO2869
            STO: ST0114
            SCE: YKL029C(MAE1)
            SPO: MAE2(mae2)
            HSA: 4200(ME2)
MOTIF       PS: PS00331  F-x-[DV]-D-x(2)-G-T-[GSA]-x-[IV]-x-[LIVMA]-[GAST](2)-
                         [LIVMF](2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.38
            ExPASy - ENZYME nomenclature database: 1.1.1.38
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.38
            BRENDA, the Enzyme Database: 1.1.1.38
///
ENTRY       EC 1.1.1.39
NAME        Malate dehydrogenase (decarboxylating)
            'Malic' enzyme
            Pyruvic-malic carboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Malate:NAD+ oxidoreductase (decarboxylating)
REACTION    (S)-Malate + NAD+ = Pyruvate + CO2 + NADH
SUBSTRATE   (S)-Malate
            NAD+
PRODUCT     Pyruvate
            CO2
            NADH
COMMENT     Does not decarboxylate added oxaloacetate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
GENES       MLO: mlr0809
            SME: SMc00169(dme)
            SPY: SPy1110
            MMU: 97043(Mod1)
MOTIF       PS: PS00331  F-x-[DV]-D-x(2)-G-T-[GSA]-x-[IV]-x-[LIVMA]-[GAST](2)-
                         [LIVMF](2)
STRUCTURES  PDB: 1QR6  1EFL  1EFK  1DO8  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.39
            ExPASy - ENZYME nomenclature database: 1.1.1.39
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.39
            BRENDA, the Enzyme Database: 1.1.1.39
            SCOP (Structural Classification of Proteins): 1.1.1.39
///
ENTRY       EC 1.1.1.40
NAME        Malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)
            'Malic' enzyme
            Pyruvate-malic carboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Malate:NADP+ oxidoreductase(oxaloacetate-decarboxylating)
REACTION    (S)-Malate + NADP+ = Pyruvate + CO2 + NADPH
SUBSTRATE   (S)-Malate
            NADP+
            Oxaloacetate
PRODUCT     Pyruvate
            CO2
            NADPH
COMMENT     Also decarboxylates added oxaloacetate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b2463
            ECE: Z3719
            YPE: YPO3034(maeB)
            HIN: HI1245
            PMU: PM0002(mdh_1)
            XFA: XF0977
            RPR: RP373(tme)
            MLO: mlr5329
            SME: SMc01126(tme)
            CCR: CC2622 CC3549
            BSU: BG12614(malS)
            CAC: CAC1589(malS) CAC1596(malS)
            HAL: VNG1624G(mdh)
            DME: CG10120 CG10120_1 CG5889(Mdh)
            MMU: 97047(Mod2-s)
            HSA: 10873(ME3) 4199(ME1)
DISEASE     MIM: 154250  Malic enzyme, cytoplasmic
            MIM: 154270  Malic enzyme, mitochondrial
MOTIF       PS: PS00331  F-x-[DV]-D-x(2)-G-T-[GSA]-x-[IV]-x-[LIVMA]-[GAST](2)-
                         [LIVMF](2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.40
            ExPASy - ENZYME nomenclature database: 1.1.1.40
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.40
            BRENDA, the Enzyme Database: 1.1.1.40
///
ENTRY       EC 1.1.1.41
NAME        Isocitrate dehydrogenase (NAD+)
            Isocitric dehydrogenase
            beta-Ketoglutaric-isocitric carboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Isocitrate:NAD+ oxidoreductase(decarboxylating)
REACTION    Isocitrate + NAD+ = 2-Oxoglutarate + CO2 + NADH
SUBSTRATE   Isocitrate
            NAD+
            (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
PRODUCT     2-Oxoglutarate
            CO2
            NADH
COMMENT     The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-
            -1,2,3-tricarboxylate, formerly termed threo-Ds-isocitrate (4109).
            Does not decarboxylate added oxalosuccinate.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
GENES       XFA: XF2596
            CAC: CAC0972(citC)
            SCE: YNL037C(IDH1) YOR136W(IDH2)
            SPO: SPAC11G7.03(spac11g7.03) SPBC902.05C(spbc902.05c)
            ATH: At2g17130(F6P23.14) At4g35260(F23E12.180)
            CEL: C37E2.1 F35G12.2 F43G9.1
            DME: CG12231 CG12233 CG12333 CG5028 CG6439
            HSA: 3419(IDH3A) 3420(IDH3B) 3421(IDH3G)
DISEASE     MIM: 300089  Isocitrate dehydrogenase 3 (NAD+), gamma
            MIM: 601149  Isocitrate dehydrogenase 3 (NAD+) alpha
MOTIF       PS: PS00470  [NS]-[LIMYT]-[FYDN]-G-[DNGST]-[IMVY]-x-[STGDN]-[DN]-
                         x(2)-[SGAP]-x(3,4)-G-[STG]-[LIVMPA]-G-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.41
            ExPASy - ENZYME nomenclature database: 1.1.1.41
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.41
            BRENDA, the Enzyme Database: 1.1.1.41
///
ENTRY       EC 1.1.1.42
NAME        Isocitrate dehydrogenase (NADP+)
            Oxalosuccinate decarboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Isocitrate:NADP+ oxidoreductase (decarboxylating)
REACTION    Isocitrate + NADP+ = 2-Oxoglutarate + CO2 + NADPH
SUBSTRATE   Isocitrate
            (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
            NADP+
PRODUCT     2-Oxoglutarate
            CO2
            NADPH
COMMENT     The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-
            1,2,3-tricarboxylate, formerly termed threo-Ds-isocitrate.
            Also decarboxylates added oxalosuccinate.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00480  Glutathione metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b1136(icd)
            ECE: Z1865(icdA)
            ECS: ECs1608
            YPE: YPO1641(icdA)
            PMU: PM1606(idp)
            XFA: XF2700
            VCH: VC1141
            PAE: PA2623(icd) PA2624(idh)
            NME: NMB0920
            NMA: NMA1116(icd)
            HPY: HP0027(icd)
            HPJ: jhp0023
            CJE: Cj0531(icd)
            RPR: RP265(icd)
            RCO: RC0353(icd)
            MLO: mll0036
            SME: SMc00480(icd)
            CCR: CC2522
            BSU: BG10856(citC)
            BHA: BH3159(citC)
            SAU: SA1517(citC)
            SAV: SAV1680(citC)
            LLA: L71075(icd)
            MTU: Rv0066c Rv3339c(icd1)
            MTC: MT0072 MT3442
            MLE: ML2672(icd2)
            SYN: slr1289(icd)
            DRA: DR1540 DR1674
            AAE: aq_1512(icd)
            TMA: TM1148
            MJA: MJ1596(icd)
            MTH: MTH184
            AFU: AF0647(icd)
            HAL: VNG1873G(icd)
            TAC: Ta0117
            TVO: TVG0201218
            APE: APE0689
            SSO: SSO2182(idh)
            SCE: YDL066W(IDP1) YLR174W(IDP2) YNL009W(IDP3)
            SPO: SPAC6G10.08(spac6g10.08)
            CEL: C34F6.8 F59B8.2
            DME: CG7176 CG7176_1 CG7176_2
            MMU: 96413(Idh1)
            HSA: 3417(IDH1) 3418(IDH2)
DISEASE     MIM: 147650  Isocitrate dehydrogenase, mitochondrial
            MIM: 147700  Isocitrate dehydrogenase, soluble
MOTIF       PS: PS00470  [NS]-[LIMYT]-[FYDN]-G-[DNGST]-[IMVY]-x-[STGDN]-[DN]-
                         x(2)-[SGAP]-x(3,4)-G-[STG]-[LIVMPA]-G-[LIVMF]
STRUCTURES  PDB: 7ICD  1AI2  1AI3  8ICD  9ICD  6ICD  5ICD  4ICD  3ICD  1SJS  
                 1ISO  1IKA  1IDF  1IDE  1IDD  1IDC  1HQS  1HJ6  1GRP  1BL5  
                 1CW1  1CW4  1CW7  1GRO  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.42
            ExPASy - ENZYME nomenclature database: 1.1.1.42
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.42
            BRENDA, the Enzyme Database: 1.1.1.42
            SCOP (Structural Classification of Proteins): 1.1.1.42
///
ENTRY       EC 1.1.1.43
NAME        Phosphogluconate 2-dehydrogenase
            6-Phosphogluconic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-Phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
REACTION    6-Phospho-D-gluconate + NAD+ or NADP+ =
            6-Phospho-2-dehydro-D-gluconate + NADH or NADPH
SUBSTRATE   6-Phospho-D-gluconate
            NAD+
            NADP+
PRODUCT     6-Phospho-2-dehydro-D-gluconate
            NADH
            NADPH
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.43
            ExPASy - ENZYME nomenclature database: 1.1.1.43
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.43
            BRENDA, the Enzyme Database: 1.1.1.43
///
ENTRY       EC 1.1.1.44
NAME        Phosphogluconate dehydrogenase (decarboxylating)
            Phosphogluconic acid dehydrogenase
            6-Phosphogluconic dehydrogenase
            6-Phosphogluconic carboxylase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-Phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)
REACTION    6-Phospho-D-gluconate + NADP+ = D-Ribulose 5-phosphate + CO2 +
            NADPH
SUBSTRATE   6-Phospho-D-gluconate
            NADP+
            NAD+
PRODUCT     D-Ribulose 5-phosphate
            CO2
            NADPH
            NADH
COFACTOR    Manganese
COMMENT     Certain preparations reduce NAD+ as well as NADP+.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b2029(gnd)
            ECE: Z3191(gnd)
            ECS: ECs2830
            YPE: YPO1541(gnd)
            HIN: HI0553(gnd)
            PMU: PM1554(gnd)
            VCH: VCA0898
            BUC: BU107(gnd)
            NME: NMB0015
            NMA: NMA0262(gnd)
            MLO: mll3321 mlr4206
            SME: SMc04262(gnd)
            BSU: BG10651(gntZ) BG11631(yqeC) BG11738(yqjI)
            BHA: BH2674
            SAU: SA1342(gnd)
            SAV: SAV1500(gnd)
            LLA: L0046(gnd) L53699(gntZ)
            SPN: SP0375
            SPR: spr0335(gnd)
            MTU: Rv1122(gnd2) Rv1844c(gnd)
            MTC: MT1154 MT1892
            MLE: ML2065(gnd)
            CTR: CT063
            CMU: TC0333
            CPN: CPn0360
            CPA: CP0398
            CPJ: gnd
            BBU: BB0561(gnd)
            TPA: TP0331
            SYN: sll0329(gnd)
            DRA: DR1595
            AAE: aq_498(gnd)
            TMA: TM0438
            SCE: YGR256W(GND2) YHR183W(GND1)
            SPO: SPBC660.16(spbc660.16)
            CEL: T25B9.9
            DME: CG3724(Pgd)
            HSA: 5226(PGD)
DISEASE     MIM: 172200  6-phosphogluconate dehydrogenase
MOTIF       PS: PS00461  [LIVM]-x-D-x(2)-[GA]-[NQS]-K-G-T-G-x-W
STRUCTURES  PDB: 2PGD  1PGQ  1PGP  1PGO  1PGN  1PGJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.44
            ExPASy - ENZYME nomenclature database: 1.1.1.44
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.44
            BRENDA, the Enzyme Database: 1.1.1.44
            SCOP (Structural Classification of Proteins): 1.1.1.44
///
ENTRY       EC 1.1.1.45
NAME        L-Gulonate 3-dehydrogenase
            L-3-Aldonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Gulonate:NAD+ 3-oxidoreductase
REACTION    L-Gulonate + NAD+ = 3-Dehydro-L-gulonate + NADH
SUBSTRATE   L-Gulonate
            NAD+
PRODUCT     3-Dehydro-L-gulonate
            NADH
COMMENT     Also oxidizes other L-3-hydroxyacids.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.45
            ExPASy - ENZYME nomenclature database: 1.1.1.45
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.45
            BRENDA, the Enzyme Database: 1.1.1.45
///
ENTRY       EC 1.1.1.46
NAME        L-Arabinose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Arabinose:NAD+ 1-oxidoreductase
REACTION    L-Arabinose + NAD+ = L-Arabinono-1,4-lactone + NADH
SUBSTRATE   L-Arabinose
            NAD+
PRODUCT     L-Arabinono-1,4-lactone
            NADH
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.46
            ExPASy - ENZYME nomenclature database: 1.1.1.46
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.46
            BRENDA, the Enzyme Database: 1.1.1.46
///
ENTRY       EC 1.1.1.47
NAME        Glucose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     beta-D-Glucose:NAD(P)+ 1-oxoreductase
REACTION    beta-D-Glucose + NAD+ or NADP+ = D-Glucono-1,5-lactone +
            NADH or NADPH
SUBSTRATE   beta-D-Glucose
            D-Xylose
            NAD+
            NADP+
PRODUCT     D-Glucono-1,5-lactone
            NADH
            NADPH
COMMENT     Also oxidizes D-xylose.
            The bacterial enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       BSU: BG10545(gdh) BG12761(ycdF)
            SYN: sll1709(gdh)
            TAC: Ta0191 Ta0897
            TVO: TVG1073292
            SSO: SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
            HSA: 2663(GDH) 9563(H6PD)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1GCO  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.47
            ExPASy - ENZYME nomenclature database: 1.1.1.47
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.47
            BRENDA, the Enzyme Database: 1.1.1.47
            SCOP (Structural Classification of Proteins): 1.1.1.47
///
ENTRY       EC 1.1.1.48
NAME        Galactose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Galactose:NAD+ 1-oxidoreductase
REACTION    D-Galactose + NAD+ = D-Galactono-1,4-lactone + NADH
SUBSTRATE   D-Galactose
            NAD+
PRODUCT     D-Galactono-1,4-lactone
            NADH
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.48
            ExPASy - ENZYME nomenclature database: 1.1.1.48
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.48
            BRENDA, the Enzyme Database: 1.1.1.48
///
ENTRY       EC 1.1.1.49
NAME        Glucose-6-phosphate 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glucose-6-phosphonate:NADP+ 1-oxoreductase
REACTION    D-Glucose 6-phosphate + NADP+ = D-Glucono-1,5-lactone 6-phosphate
            + NADPH
SUBSTRATE   D-Glucose 6-phosphate
            beta-D-Glucose
            Sugar
            NADP+
            NAD+
PRODUCT     D-Glucono-1,5-lactone 6-phosphate
            NADPH
            NADH
INHIBITOR   Fatty acid
COMMENT     Also acts slowly on beta-D-glucose and other sugars. Certain
            preparations also reduce NAD+ as well as NADP+.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00480  Glutathione metabolism
GENES       ECO: b1852(zwf)
            ECE: Z2904(zwf)
            ECS: ECs2562
            YPE: YPO2066(zwf)
            HIN: HI0558(zwf)
            PMU: PM1549(zwf)
            XFA: XF1065
            VCH: VCA0896
            PAE: PA3183(zwf) PA5439
            BUC: BU320(zwf)
            NME: NMB1392
            NMA: NMA1609(zwf)
            HPY: HP1101(zwf)
            HPJ: jhp1027
            MLO: mll6516 mlr4207
            SME: SMc03070(zwf)
            CCR: CC2057
            BSU: BG11739(zwf)
            SAU: SA1336
            SAV: SAV1494
            LLA: L0044(zwf)
            SPN: SP1243
            SPR: spr1122(zwf)
            MTU: Rv1121(zwf) Rv1447c(zwf2)
            MTC: MT1153 MT1494
            CTR: CT185
            CMU: TC0457
            CPN: CPn0238
            CPA: CP0524
            CPJ: zwf
            BBU: BB0636(zwf)
            TPA: TP0478
            SYN: slr1843(zwf)
            DRA: DR1596
            AAE: aq_497(gsdA)
            TMA: TM1155
            SCE: YNL241C(ZWF1)
            SPO: ZWF1(zwf1)
            ATH: At1g24280(F3I6.22)
            CEL: B0035.5
            DME: CG12529 CG12529_1 CG7140
            MMU: 105977(G6pd2) 105979(G6pdx)
            HSA: 2539(G6PD)
DISEASE     MIM: 305900  Glucose-6-phosphate dehydrogenase
MOTIF       PS: PS00069  D-H-Y-L-G-K-[EQK]
STRUCTURES  PDB: 1E7M  1DPG  1QKI  1E77  1E7Y  1H93  1H94  1H9A  1H9B  2DPG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.49
            ExPASy - ENZYME nomenclature database: 1.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.49
            BRENDA, the Enzyme Database: 1.1.1.49
            SCOP (Structural Classification of Proteins): 1.1.1.49
///
ENTRY       EC 1.1.1.50
NAME        3alpha-Hydroxysteroid dehydrogenase (B-specific)
            Hydroxyprostaglandin dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha-Hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)
REACTION    Androsterone + NAD+ or NADP+ = 5alpha-Androstane-3,17-dione +
            NADH or NADPH
SUBSTRATE   Androsterone
            NAD+
            NADP+
            3alpha-Hydroxysteroid
            9-Hydroxyprostaglandin
            11-Hydroxyprostaglandin
            15-Hydroxyprostaglandin
PRODUCT     5alpha-Androstane-3,17-dione
            NADH
            NADPH
COMMENT     Also acts on other 3alpha-hydroxysteroids and on 9-, 11- and
            15-hydroxyprostaglandin. B-specific with respect to NAD+ or NADP+.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
STRUCTURES  PDB: 1RAL  1AFS  1FJH  1FK8  1LWI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.50
            ExPASy - ENZYME nomenclature database: 1.1.1.50
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.50
            BRENDA, the Enzyme Database: 1.1.1.50
            SCOP (Structural Classification of Proteins): 1.1.1.50
///
ENTRY       EC 1.1.1.51
NAME        3(or 17)beta-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3(or 17)beta-Hydroxysteroid:NAD(P)+ oxidoreductase
REACTION    Testosterone + NAD+ or NADP+ = Androst-4-ene-3,17-dione +
            NADH or NADPH
SUBSTRATE   Testosterone
            NAD+
            NADP+
            3beta-Hydroxysteroid
            17beta-Hydroxysteroid
PRODUCT     Androst-4-ene-3,17-dione
            NADH
            NADPH
COMMENT     Also acts on other 3beta- or 17beta-hydroxysteroids.
            cf. EC 1.1.1.209.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.51
            ExPASy - ENZYME nomenclature database: 1.1.1.51
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.51
            BRENDA, the Enzyme Database: 1.1.1.51
///
ENTRY       EC 1.1.1.52
NAME        3alpha-Hydroxycholanate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha-Hydroxy-5beta-cholanate:NAD+ oxidoreductase
REACTION    3alpha-Hydroxy-5beta-cholanate + NAD+ = 3-Oxo-5beta-cholanate +
            NADH
SUBSTRATE   3alpha-Hydroxy-5beta-cholanate
            NAD+
            3alpha-Hydroxysteroid
PRODUCT     3-Oxo-5beta-cholanate
            NADH
            3-Oxo-hydroxysteroid
COMMENT     Also acts on other 3alpha-hydroxysteroids with an acidic
            side-chain.
STRUCTURES  PDB: 1IHI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.52
            ExPASy - ENZYME nomenclature database: 1.1.1.52
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.52
            BRENDA, the Enzyme Database: 1.1.1.52
///
ENTRY       EC 1.1.1.53
NAME        3alpha(or 20beta)-Hydroxysteroid dehydrogenase
            Cortisone reductase
            (R)-20-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha(or 20beta)-Hydroxysteroid:NAD+ oxidoreductase
REACTION    Androstan-3alpha,17beta-diol + NAD+ =
            17beta-Hydroxyandrostan-3-one + NADH
SUBSTRATE   Androstan-3alpha,17beta-diol
            NAD+
            Pregnane
            Androstane
PRODUCT     17beta-Hydroxyandrostan-3-one
            NADH
COMMENT     The 3alpha-hydroxyl group or 20beta-hydroxyl group of pregnane and
            androstane steroids can act as donor.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00140  C21-Steroid hormone metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 2HSD  1HU4  1HDC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.53
            ExPASy - ENZYME nomenclature database: 1.1.1.53
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.53
            BRENDA, the Enzyme Database: 1.1.1.53
            SCOP (Structural Classification of Proteins): 1.1.1.53
///
ENTRY       EC 1.1.1.54
NAME        Allyl-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Allyl-alcohol:NADP+ oxidoreductase
REACTION    Allyl alcohol + NADP+ = Acrolein + NADPH
SUBSTRATE   Allyl alcohol
            NADP+
PRODUCT     Acrolein
            NADPH
COMMENT     Also acts on saturated primary alcohols.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.54
            ExPASy - ENZYME nomenclature database: 1.1.1.54
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.54
            BRENDA, the Enzyme Database: 1.1.1.54
///
ENTRY       EC 1.1.1.55
NAME        Lactaldehyde reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Propane-1,2-diol:NADP+ oxidoreductase
REACTION    Propane-1,2-diol + NADP+ = L-Lactaldehyde + NADPH
SUBSTRATE   Propane-1,2-diol
            NADP+
PRODUCT     L-Lactaldehyde
            NADPH
COMMENT     May be identical with EC 1.1.1.2.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.55
            ExPASy - ENZYME nomenclature database: 1.1.1.55
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.55
            BRENDA, the Enzyme Database: 1.1.1.55
///
ENTRY       EC 1.1.1.56
NAME        Ribitol 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Ribitol:NAD+ 2-oxidoreductase
REACTION    Ribitol + NAD+ = D-Ribulose + NADH
SUBSTRATE   Ribitol
            NAD+
PRODUCT     D-Ribulose
            NADH
COMMENT     The bacterial enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.56
            ExPASy - ENZYME nomenclature database: 1.1.1.56
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.56
            BRENDA, the Enzyme Database: 1.1.1.56
///
ENTRY       EC 1.1.1.57
NAME        Fructuronate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannonate:NAD+ 5-oxidoreductase
REACTION    D-Mannonate + NAD+ = D-Fructuronate + NADH
SUBSTRATE   D-Mannonate
            NAD+
PRODUCT     D-Fructuronate
            NADH
            D-Tagaturonate
COMMENT     Also reduces D-tagaturonate.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b4323(uxuB)
            ECE: Z5921(uxuB)
            ECS: ECs5282
            SME: SMb20749(uxuB)
            LLA: L0241(uxuB)
            TMA: TM0068
MOTIF       PS: PS00974  [LIVMY]-x-[FS]-x(2)-[STAGCV]-x-V-D-R-[IV]-x-[PS]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.57
            ExPASy - ENZYME nomenclature database: 1.1.1.57
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.57
            BRENDA, the Enzyme Database: 1.1.1.57
///
ENTRY       EC 1.1.1.58
NAME        Tagaturonate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Altronate:NAD+ 3-oxidoreductase
REACTION    D-Altronate + NAD+ = D-Tagaturonate + NADH
SUBSTRATE   D-Altronate
            NAD+
PRODUCT     D-Tagaturonate
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b1521(uxaB)
            ECE: Z2184(uxaB)
            ECS: ECs2128
            YPE: YPO0580(uxaB)
            BSU: BG13212(uxaB)
            BHA: BH0492
            CAC: CAC0695
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.58
            ExPASy - ENZYME nomenclature database: 1.1.1.58
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.58
            BRENDA, the Enzyme Database: 1.1.1.58
///
ENTRY       EC 1.1.1.59
NAME        3-Hydroxypropionate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Hydroxypropanoate:NAD+ oxidoreductase
REACTION    3-Hydroxypropanoate + NAD+ = 3-Oxopropanoate + NADH
SUBSTRATE   3-Hydroxypropanoate
            NAD+
PRODUCT     3-Oxopropanoate
            NADH
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.59
            ExPASy - ENZYME nomenclature database: 1.1.1.59
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.59
            BRENDA, the Enzyme Database: 1.1.1.59
///
ENTRY       EC 1.1.1.60
NAME        2-Hydroxy-3-oxopropionate reductase
            Tartronate semialdehyde reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Glycerate:NAD(P)+ oxidoreductase
REACTION    (R)-Glycerate + NAD+ or NADP+ = 2-Hydroxy-3-oxopropanoate +
            NADH or NADPH
SUBSTRATE   (R)-Glycerate
            NAD+
            NADP+
PRODUCT     2-Hydroxy-3-oxopropanoate
            NADH
            NADPH
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b0509(ybbQ) b3125(yhaE)
            ECE: Z0663(ybbQ) Z4477(yhaE)
            ECS: ECs0570 ECs4003
            YPE: YPO3648
            MLO: mlr0254
            SME: SMb20679(glxR)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.60
            ExPASy - ENZYME nomenclature database: 1.1.1.60
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.60
            BRENDA, the Enzyme Database: 1.1.1.60
///
ENTRY       EC 1.1.1.61
NAME        4-Hydroxybutyrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Hydroxybutanoate:NAD+ oxidoreductase
REACTION    4-Hydroxybutanoate + NAD+ = Succinate semialdehyde + NADH
SUBSTRATE   4-Hydroxybutanoate
            NAD+
PRODUCT     Succinate semialdehyde
            NADH
PATHWAY     PATH: MAP00650  Butanoate metabolism
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.61
            ExPASy - ENZYME nomenclature database: 1.1.1.61
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.61
            BRENDA, the Enzyme Database: 1.1.1.61
///
ENTRY       EC 1.1.1.62
NAME        Estradiol 17beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Estradiol-17beta:NAD(P)+ 17-oxidoreductase
REACTION    Estradiol-17beta + NAD+ or NADP+ = Estrone + NADH or NADPH
SUBSTRATE   Estradiol-17beta
            (S)-20-Hydroxypregn-4-en-3-one
            NAD+
            NADP+
PRODUCT     Estrone
            (S)-Pregn-4-en-3,20-dione
            NADH
            NADPH
COMMENT     Also acts on (S)-20-hydroxypregn-4-en-3-one and related
            compounds, oxidizing the (S)-20-group. B-specific with respect
            to NAD(P)+ (cf. EC 1.1.1.149).
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
GENES       CEL: F11A5.12
            DME: CG1444 CG3415
            HSA: 3292(HSD17B1) 3293(HSD17B3) 3294(HSD17B2) 3295(HSD17B4)
                 3296(HSD17BP1) 51478(HSD17B7)
DISEASE     MIM: 109685  Hydroxysteroid (17-beta) dehydrogenase 2
            MIM: 264300  Hydroxysteroid (17-beta) dehydrogenase 3
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
STRUCTURES  PDB: 1DHT  1EQU  1BHS  1A27  1FDS  1FDT  1FDU  1FDV  1FDW  1IOL  
                 3DHE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.62
            ExPASy - ENZYME nomenclature database: 1.1.1.62
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.62
            BRENDA, the Enzyme Database: 1.1.1.62
            SCOP (Structural Classification of Proteins): 1.1.1.62
///
ENTRY       EC 1.1.1.63
NAME        Testosterone 17beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     17beta-Hydroxysteroid:NAD+ 17-oxidoreductase
REACTION    Testosterone + NAD+ = Androst-4-ene-3,17-dione + NADH
SUBSTRATE   Testosterone
            NAD+
PRODUCT     Androst-4-ene-3,17-dione
            NADH
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.63
            ExPASy - ENZYME nomenclature database: 1.1.1.63
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.63
            BRENDA, the Enzyme Database: 1.1.1.63
///
ENTRY       EC 1.1.1.64
NAME        Testosterone 17beta-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     17beta-Hydroxysteroid:NADP+ 17-oxidoreductase
REACTION    Testosterone + NADP+ = Androst-4-ene-3,17-dione + NADPH
SUBSTRATE   Testosterone
            NADP+
            3-Hydroxyhexobarbital
PRODUCT     Androst-4-ene-3,17-dione
            NADPH
            3-Oxohexobarbital
COMMENT     Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.64
            ExPASy - ENZYME nomenclature database: 1.1.1.64
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.64
            BRENDA, the Enzyme Database: 1.1.1.64
///
ENTRY       EC 1.1.1.65
NAME        Pyridoxine 4-dehydrogenase
            Pyridoxin dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pyridoxine:NADP+ 4-oxidoreductase
REACTION    Pyridoxine + NADP+ = Pyridoxal + NADPH
SUBSTRATE   Pyridoxine
            NADP+
            Pyridoxine phosphate
PRODUCT     Pyridoxal
            NADPH
            Pyridoxal phosphate
COMMENT     Also oxidizes pyridoxine phosphate
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.65
            ExPASy - ENZYME nomenclature database: 1.1.1.65
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.65
            BRENDA, the Enzyme Database: 1.1.1.65
///
ENTRY       EC 1.1.1.66
NAME        omega-Hydroxydecanoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     10-Hydroxydecanoate:NAD+ 10-oxidoreductase
REACTION    10-Hydroxydecanoate + NAD+ = 10-Oxodecanoate + NADH
SUBSTRATE   10-Hydroxydecanoate
            NAD+
PRODUCT     10-Oxodecanoate
            NADH
COMMENT     Also acts, more slowly, on 9-hydroxynonanoate and
            11-hydroxyundecanoate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.66
            ExPASy - ENZYME nomenclature database: 1.1.1.66
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.66
            BRENDA, the Enzyme Database: 1.1.1.66
///
ENTRY       EC 1.1.1.67
NAME        Mannitol 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannitol:NAD+ 2-oxidoreductase
REACTION    D-Mannitol + NAD+ = D-Fructose + NADH
SUBSTRATE   D-Mannitol
            NAD+
PRODUCT     D-Fructose
            NADH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       MLO: mlr4057
            SME: SMc01501(mtlK)
            CCR: CC1487
MOTIF       PS: PS00974  [LIVMY]-x-[FS]-x(2)-[STAGCV]-x-V-D-R-[IV]-x-[PS]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.67
            ExPASy - ENZYME nomenclature database: 1.1.1.67
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.67
            BRENDA, the Enzyme Database: 1.1.1.67
///
ENTRY       EC 1.1.1.68
NAME        Transferred to EC 1.7.99.5
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.7.99.5 -
            5,10-Methylenetetrahydrofolate reductase (FADH2).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.68
            ExPASy - ENZYME nomenclature database: 1.1.1.68
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.68
///
ENTRY       EC 1.1.1.69
NAME        Gluconate 5-dehydrogenase
            5-Keto-D-gluconate 5-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Gluconate:NAD(P)+ 5-oxidoreductase
REACTION    D-Gluconate + NAD+ or NADP+ = 5-Dehydro-D-gluconate + NADH or NADPH
SUBSTRATE   D-Gluconate
            NAD+
            NADP+
PRODUCT     5-Dehydro-D-gluconate
            NADH
            NADPH
GENES       ECO: b4266(yjgU)
            YPE: YPO2539(idnO)
            SME: SMa0513(idnO1) SMb20692(idnO1)
            CCR: CC1286
            SPY: SPy0636(idnO)
            SPN: SP0320
            SPR: spr0290(gno)
            CAC: CAC2607
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.69
            ExPASy - ENZYME nomenclature database: 1.1.1.69
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.69
            BRENDA, the Enzyme Database: 1.1.1.69
///
ENTRY       EC 1.1.1.70
NAME        Deleted entry
            D-Glucuronolactone dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.2.1.3, Aldehyde
            dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.70
            ExPASy - ENZYME nomenclature database: 1.1.1.70
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.70
///
ENTRY       EC 1.1.1.71
NAME        Alcohol dehydrogenase (NAD(P)+)
            Retinal reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Alcohol:NAD(P)+ oxidoreductase
REACTION    an Alcohol + NAD+ or NADP+ = an Aldehyde + NADH or NADPH
SUBSTRATE   Alcohol
            NAD+
            NADP+
            Retinal
PRODUCT     Aldehyde
            NADH
            NADPH
            Retinol
COMMENT     Reduced aliphatic aldehydes of carbon chin length from 2 to 14,
            with greatest activity on C4, C6 and C8 aldehyde; also reduce
            retinal to retinol.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.71
            ExPASy - ENZYME nomenclature database: 1.1.1.71
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.71
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.71
            BRENDA, the Enzyme Database: 1.1.1.71
///
ENTRY       EC 1.1.1.72
NAME        Glycerol dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycerol:NADP+ oxidoreductase
REACTION    Glycerol + NADP+ = D-Glyceraldehyde + NADPH
SUBSTRATE   Glycerol
            NADP+
PRODUCT     D-Glyceraldehyde
            NADPH
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.72
            ExPASy - ENZYME nomenclature database: 1.1.1.72
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.72
            BRENDA, the Enzyme Database: 1.1.1.72
///
ENTRY       EC 1.1.1.73
NAME        Octanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     OctanolLNAD+ oxidoreductase
REACTION    1-Octanol + NAD+ = 1-Octanal + NADH
SUBSTRATE   1-Octanol
            NAD+
PRODUCT     1-Octanal
            NADH
COMMENT     Acts, less rapidly, on other long-chain alcohols.
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.73
            ExPASy - ENZYME nomenclature database: 1.1.1.73
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.73
            BRENDA, the Enzyme Database: 1.1.1.73
///
ENTRY       EC 1.1.1.74
NAME        Deleted entry
            D-Aminopropanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. (reaction due to EC 1.1.1.4.)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.74
            ExPASy - ENZYME nomenclature database: 1.1.1.74
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.74
///
ENTRY       EC 1.1.1.75
NAME        (R)-Aminopropanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-1-Aminopropan-2-ol:NAD+ oxidoreductase
REACTION    (R)-1-Aminopropan-2-ol + NAD+ = Aminoacetone + NADH
SUBSTRATE   (R)-1-Aminopropan-2-ol
            NAD+
PRODUCT     Aminoacetone
            NADH
COFACTOR    K+
COMMENT     Requires K+.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.75
            ExPASy - ENZYME nomenclature database: 1.1.1.75
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.75
            BRENDA, the Enzyme Database: 1.1.1.75
///
ENTRY       EC 1.1.1.76
NAME        (S,S)-Butanediol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S,S)-Butane-2,3-diol:NAD+ oxidoreductase
REACTION    (S,S)-Butane-2,3-diol + NAD+ = Acetoin + NADH
SUBSTRATE   (S,S)-Butane-2,3-diol
            NAD+
PRODUCT     Acetoin
            NADH
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.76
            ExPASy - ENZYME nomenclature database: 1.1.1.76
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.76
            BRENDA, the Enzyme Database: 1.1.1.76
///
ENTRY       EC 1.1.1.77
NAME        Lactaldehyde reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     [(R) or (S)]-Propane-1,2-diol:NAD+ oxidoreductase
REACTION    (R)-Propane-1,2-diol or (S)-Propane-1,2-diol + NAD+ = 
            (R)-Lactaldehyde or (S)-Lactaldehyde + NADH
SUBSTRATE   (R)-Propane-1,2-diol
            (S)-Propane-1,2-diol
            NAD+
PRODUCT     (R)-Lactaldehyde
            (S)-Lactaldehyde
            NADH
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b2799(fucO)
            ECE: Z4116(fucO)
            ECS: ECs3659
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.77
            ExPASy - ENZYME nomenclature database: 1.1.1.77
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.77
            BRENDA, the Enzyme Database: 1.1.1.77
///
ENTRY       EC 1.1.1.78
NAME        D-Lactaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Lactaldehyde:NAD+ oxidoreductase
REACTION    (R)-Lactaldehyde + NAD+ = Methylglyoxal + NADH
SUBSTRATE   (R)-Lactaldehyde
            NAD+
PRODUCT     Methylglyoxal
            NADH
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.78
            ExPASy - ENZYME nomenclature database: 1.1.1.78
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.78
            BRENDA, the Enzyme Database: 1.1.1.78
///
ENTRY       EC 1.1.1.79
NAME        Glyoxylate reductase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycolate:NADP+ oxidoreductase
REACTION    Glycolate + NADP+ = Glyoxylate + NADPH
SUBSTRATE   Glycolate
            NADP+
            Hydroxypyruvate
PRODUCT     Glyoxylate
            NADPH
            Glycerate
COMMENT     Also reduces hydroxypyruvate to glycerate; has some affinity for
            NAD+.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DISEASE     MIM: 604296  Glyoxylate reductase/hydroxypyruvate reductase
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.79
            ExPASy - ENZYME nomenclature database: 1.1.1.79
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.79
            BRENDA, the Enzyme Database: 1.1.1.79
///
ENTRY       EC 1.1.1.80
NAME        Isopropanol dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Propan-2-ol:NADP+ oxidoreductase
REACTION    Propan-2-ol + NADP+ = Acetone + NADPH
SUBSTRATE   Propan-2-ol
            NADP+
PRODUCT     Acetone
            NADPH
COMMENT     Also acts on other short-chain secondary alcohols, and, slowly, on
            primary alcohols.
PATHWAY     PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.80
            ExPASy - ENZYME nomenclature database: 1.1.1.80
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.80
            BRENDA, the Enzyme Database: 1.1.1.80
///
ENTRY       EC 1.1.1.81
NAME        Hydroxypyruvate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glycerate:NADP+ 2-oxidoreductase
REACTION    D-Glycerate + NAD+ or NADP+ = Hydroxypyruvate + NADH or NADPH
SUBSTRATE   D-Glycerate
            NAD+
            NADP+
PRODUCT     Hydroxypyruvate
            NADH
            NADPH
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       YPE: YPO2536
            SME: SMb20678(ttuD2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.81
            ExPASy - ENZYME nomenclature database: 1.1.1.81
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.81
            BRENDA, the Enzyme Database: 1.1.1.81
///
ENTRY       EC 1.1.1.82
NAME        Malate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Malate:NADP+ oxidoreductase
REACTION    (S)-Malate + NADP+ = Oxaloacetate + NADPH
SUBSTRATE   (S)-Malate
            NADP+
PRODUCT     Oxaloacetate
            NADPH
EFFECTOR    hv
COMMENT     Activated by light.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
MOTIF       PS: PS00068  [LIVM]-T-[TRKMN]-L-D-x(2)-R-[STA]-x(3)-[LIVMFY]
STRUCTURES  PDB: 7MDH  1CIV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.82
            ExPASy - ENZYME nomenclature database: 1.1.1.82
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.82
            BRENDA, the Enzyme Database: 1.1.1.82
            SCOP (Structural Classification of Proteins): 1.1.1.82
///
ENTRY       EC 1.1.1.83
NAME        D-Malate dehydrogenase (decarboxylating)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Malate:NAD+ oxidoreductase (decarboxylating)
REACTION    (R)-Malate + NAD+ = Pyruvate + CO2 + NADH
SUBSTRATE   (R)-Malate
            NAD+
PRODUCT     Pyruvate
            CO2
            NADH
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.83
            ExPASy - ENZYME nomenclature database: 1.1.1.83
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.83
            BRENDA, the Enzyme Database: 1.1.1.83
///
ENTRY       EC 1.1.1.84
NAME        Dimethylmalate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-3,3-Dimethylmalate:NAD+ oxidoreductase (decarboxylating)
REACTION    (R)-3,3-Dimethylmalate + NAD+ = 3-Methyl-2-oxobutanoate + CO2 +
            NADH
SUBSTRATE   (R)-3,3-Dimethylmalate
            NAD+
            (R)-Malate
PRODUCT     3-Methyl-2-oxobutanoate
            CO2
            NADH
            Pyruvate
COFACTOR    K+
            NH4+
            Mn2+
            Co2+
COMMENT     Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.84
            ExPASy - ENZYME nomenclature database: 1.1.1.84
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.84
            BRENDA, the Enzyme Database: 1.1.1.84
///
ENTRY       EC 1.1.1.85
NAME        3-Isopropylmalate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Carboxy-2-hydroxy-4-methyl-pentanoate:NAD+ oxidoreductase
REACTION    3-Carboxy-2-hydroxy-4-methylpentanoate + NAD+ =
            3-Carboxy-4-methyl-2-oxopentanoate + NADH
SUBSTRATE   3-Isopropylmalate
            NAD+
            3-Carboxy-2-hydroxy-4-methylpentanoate
PRODUCT     NADH
            3-Carboxy-4-methyl-2-oxopentanoate
            4-Methyl-2-oxopentanoate
COMMENT     The product decarboxylates to 4-methyl-2-oxopentanoate.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
GENES       ECO: b0073(leuB)
            ECE: Z0082(leuB)
            ECS: ECs0077
            YPE: YPO0532(leuB)
            HIN: HI0987(leuB)
            PMU: PM1961(leuB)
            XFA: XF2372
            VCH: VC2491
            PAE: PA3118(leuB)
            BUC: BUpL05(leuB)
            NME: NMB1031
            NMA: NMA1456(leuB)
            CJE: Cj1718c(leuB)
            MLO: mll4399
            SME: SMc04405(leuB)
            ATU: AGR_C_5067
            CCR: CC0193
            BSU: BG10675(leuB)
            BHA: BH3057(leuB)
            SAU: SA1863(leuB)
            SAV: SAV2043(leuB)
            LLA: L0074(leuB)
            SPR: spr1135(leuB)
            CAC: CAC3171(leuB)
            MTU: Rv2995c(leuB)
            MTC: MT3073
            MLE: ML1691(leuB)
            SYN: slr1517(leuB)
            DRA: DR1785
            AAE: aq_244(leuB)
            TMA: TM0556
            MJA: MJ0720
            MTH: MTH1388
            AFU: AF0628(leuB)
            PHO: PH1722
            PAB: PAB0289(leuB-2) PAB2424(leuB-1)
            SSO: SSO0723(leuB)
            STO: ST0433
            SCE: YCL018W(LEU2)
            SPO: LEU1(leu1)
MOTIF       PS: PS00470  [NS]-[LIMYT]-[FYDN]-G-[DNGST]-[IMVY]-x-[STGDN]-[DN]-
                         x(2)-[SGAP]-x(3,4)-G-[STG]-[LIVMPA]-G-[LIVMF]
STRUCTURES  PDB: 1DR0  1XAC  1A05  1DR8  1G2U  1GC8  1GC9  1HEX  1XAD  2AYQ  
                 1DPZ  1IDM  1IPD  1OSI  1OSJ  1XAA  1XAB  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.85
            ExPASy - ENZYME nomenclature database: 1.1.1.85
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.85
            BRENDA, the Enzyme Database: 1.1.1.85
            SCOP (Structural Classification of Proteins): 1.1.1.85
///
ENTRY       EC 1.1.1.86
NAME        Ketol-acid reductoisomerase
            Dihydroxyisovalerate dehydrogenase (isomerizing)
            Acetohydroxy acid isomeroreductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-2,3-Dihydroxy-3-methylbutanoate:NADP+ oxidoreductase
            (isomerizing)
REACTION    (R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ =
            (S)-2-Hydroxy-2-methyl-3-oxobutanoate + NADPH
SUBSTRATE   (R)-2,3-Dihydroxy-3-methylbutanoate
            2-Aceto-2-hydroxybutanoate
            NADP+
PRODUCT     (S)-2-Hydroxy-2-methyl-3-oxobutanoate
            2,3-Dihydroxy-3-methylpentanoate
            NADPH
COMMENT     Also catalyses the reduction of 2-aceto-2-hydroxybutanoate to
            2,3-dihydroxy-3-methylpentanoate
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b3774(ilvC)
            ECE: Z5285(ilvC)
            ECS: ECs4708
            YPE: YPO3888(ilvC)
            HIN: HI0682(ilvC)
            PMU: PM1284(ilvC)
            XFA: XF1822
            VCH: VC0162
            PAE: PA4694(ilvC)
            BUC: BU599(ilvC)
            NME: NMB1574
            NMA: NMA1763(ilvC)
            HPY: HP0330(ilvC)
            HPJ: jhp0313
            CJE: Cj0632(ilvC)
            MLO: mll1405
            SME: SMc04346(ilvC)
            CCR: CC2120
            BSU: BG10672(ilvC)
            BHA: BH3059(ilvC)
            SAU: SA1861(ilvC)
            SAV: SAV2041(ilvC)
            LLA: L0080(ilvC)
            SPN: SP0447
            SPR: spr0403(ilvC)
            CAC: CAC0091(ilvC)
            MTU: Rv3001c(ilvC)
            MTC: MT3081
            MLE: ML1694(ilvC)
            SYN: sll1363(ilvC)
            DRA: DR1519
            AAE: aq_1245(ilvC)
            TMA: TM0550
            MJA: MJ1543(ilvC)
            MTH: MTH1442
            AFU: AF1985(ilvC)
            PAB: PAB0889(ilvC)
            SSO: SSO0576(ilvC-1) SSO1322(ilvC-2) SSO1942(ilvC-3)
            SCE: YLR355C(ILV5)
            SPO: SPBC56F2.12(spbc56f2.12)
STRUCTURES  PDB: 1YVE  1QMG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.86
            ExPASy - ENZYME nomenclature database: 1.1.1.86
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.86
            BRENDA, the Enzyme Database: 1.1.1.86
            SCOP (Structural Classification of Proteins): 1.1.1.86
///
ENTRY       EC 1.1.1.87
NAME        3-Carboxy-2-hydroxyadipate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)
REACTION    3-Carboxy-2-hydroxyadipate + NAD+ = 2-Oxoadipate + CO2 + NADH
SUBSTRATE   3-Carboxy-2-hydroxyadipate
            NAD+
PRODUCT     2-Oxoadipate
            CO2
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.87
            ExPASy - ENZYME nomenclature database: 1.1.1.87
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.87
            BRENDA, the Enzyme Database: 1.1.1.87
///
ENTRY       EC 1.1.1.88
NAME        Hydroxymethylglutaryl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Mevalonate:NAD+ oxidoreductase (CoA-acetylating)
REACTION    (S)-Mevalonate + CoA + 2 NAD+ = (S)-3-Hydroxy-3-methylglutaryl-CoA
            + 2 NADH
SUBSTRATE   (S)-Mevalonate
            CoA
            NAD+
PRODUCT     (S)-3-Hydroxy-3-methylglutaryl-CoA
            NADH
DISEASE     MIM: 142910  3-hydroxy-3-methylglutaryl-Coenzyme A reductase;
MOTIF       PS: PS00066  [RKH]-x(6)-D-x-M-G-x-N-x-[LIVMA]
            PS: PS00318  [LIVM]-G-x-[LIVM]-G-G-[AG]-T
            PS: PS01192  A-[LIVM]-x-[STAN]-x(2)-[LI]-x-[KRNQ]-[GSA]-H-[LM]-x-
                         [FYLH]
            PS: PS50065  Hydroxymethylglutaryl-coenzyme A reductases profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.88
            ExPASy - ENZYME nomenclature database: 1.1.1.88
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.88
            BRENDA, the Enzyme Database: 1.1.1.88
///
ENTRY       EC 1.1.1.89
NAME        Deleted entry
            Dihydroxyisovalerate dehydrogenase (isomerizing)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.1.1.86.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.89
            ExPASy - ENZYME nomenclature database: 1.1.1.89
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.89
///
ENTRY       EC 1.1.1.90
NAME        Aryl-alcohol dehydrogenase
            p-Hydroxybenzyl alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aryl-alcohol:NAD+ oxidoreductase
REACTION    an Aromatic alcohol + NAD+ = an Aromatic aldehyde + NADH
SUBSTRATE   Aromatic alcohol
            NAD+
PRODUCT     Aromatic aldehyde
            NADH
COMMENT     A group of enzymes with broad specificity towards primary alcohols
            with an aromatic or cyclohex-1-ene ring, but with low or no
            activity towards short-chain aliphatic alcohols.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00621  Biphenyl degradation
            PATH: MAP00622  Toluene degradation
            PATH: MAP00624  Xylene degradation
            PATH: MAP00930  Caprolactam degradation
GENES       CCR: CC2396
            BHA: BH2011
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.90
            ExPASy - ENZYME nomenclature database: 1.1.1.90
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.90
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.90
            BRENDA, the Enzyme Database: 1.1.1.90
///
ENTRY       EC 1.1.1.91
NAME        Aryl-alcohol dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aryl-alcohol:NAD+ oxidoreductase
REACTION    an Aromatic alcohol + NADP+ = an Aromatic aldehyde + NADPH
SUBSTRATE   Aromatic alcohol
            NADP+
PRODUCT     Aromatic aldehyde
            NADPH
COMMENT     Also acts on some aliphatic aldehydes but cinnamaldehyde was the
            best substrate found.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.91
            ExPASy - ENZYME nomenclature database: 1.1.1.91
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.91
            BRENDA, the Enzyme Database: 1.1.1.91
///
ENTRY       EC 1.1.1.92
NAME        Oxaloglycolate reductase (decarboxylating)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glycerate:NAD(P)+ oxidoreductase (carboxylating)
REACTION    D-Glycerate + NAD+ or NADP+ + CO2 = 2-Hydroxy-3-oxosuccinate +
            NADH or NADPH
SUBSTRATE   D-Glycerate
            NAD+
            NADP+
            CO2
            Glycolate
PRODUCT     2-Hydroxy-3-oxosuccinate
            NADH
            NADPH
            Hydroxypyruvate
            Glyoxalate
COMMENT     Also reduces hydroxypyruvate to D-glycerate and glyoxalate to
            glycolate.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.92
            ExPASy - ENZYME nomenclature database: 1.1.1.92
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.92
            BRENDA, the Enzyme Database: 1.1.1.92
///
ENTRY       EC 1.1.1.93
NAME        Tartrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Tartrate:NAD+ oxidoreductase
REACTION    Tartaric acid + NAD+ = Oxaloglycolate + NADH
SUBSTRATE   Tartaric acid
            NAD+
PRODUCT     Oxaloglycolate
            NADH
COFACTOR    Mn2+
COMMENT     meso-Tartaric acid and (R,R)-tartaric acid act as substrate.
            Requires Mn2+ and a monovalent cation.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b1800(yeaU)
            ECE: Z2843(yeaU)
            ECS: ECs2509
            YPE: YPO2496
            MLO: mll7044
            SME: SMa1846
            BHA: BH1070
MOTIF       PS: PS00470  [NS]-[LIMYT]-[FYDN]-G-[DNGST]-[IMVY]-x-[STGDN]-[DN]-
                         x(2)-[SGAP]-x(3,4)-G-[STG]-[LIVMPA]-G-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.93
            ExPASy - ENZYME nomenclature database: 1.1.1.93
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.93
            BRENDA, the Enzyme Database: 1.1.1.93
///
ENTRY       EC 1.1.1.94
NAME        Glycerol-3-phosphate dehydrogenase (NAD(P)+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     sn-Glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + NAD+ or NADP+ = Glycerone phosphate +
            NADH or NADPH
SUBSTRATE   sn-Glycerol 3-phosphate
            NAD+
            NADP+
PRODUCT     Glycerone phosphate
            NADH
            NADPH
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b3608(gpsA)
            ECE: Z5035(gpsA)
            ECS: ECs4486
            HIN: HI0605(gpsA)
            PMU: PM1431(gspA)
            XFA: XF1802
            VCH: VC2651(NAD+)
            PAE: PA1614(gpsA)
            NME: NMB2060
            NMA: NMA0375(gpsA)
            HPY: HP0961
            HPJ: jhp0895
            CJE: Cj1196c(gpsA)
            RPR: RP442(gpsA)
            RCO: RC0615(gpsA)
            MLO: mlr4225
            CCR: CC0070
            BSU: BG11366(gpsA)
            BHA: BH1640(gpsA)
            SAU: SA1306(gpsA)
            SAV: SAV1463(gpsA)
            LLA: L0016(gpdA)
            SPY: SPy0226(gpsA)
            SPN: SP2091
            SPR: spr1902(gpdA)
            CAC: CAC1712(gpsA)
            MTU: Rv0564c(gpdA1) Rv2982c(gpdA2)
            MTC: MT0590 MT3060
            MLE: ML1679(gpdA)
            CTR: CT714
            CMU: TC0087
            CPN: CPn0855
            CPA: CP1014
            CPJ: gpdA
            BBU: BB0368(gpsA)
            SYN: slr1755(gpsA)
            DRA: DR2621
            AAE: aq_1634(gspA)
            MTH: MTH368
            AFU: AF0871(gpsA)
MOTIF       PS: PS00957  G-[ATIV]-[LIVMYC]-K-[DN]-[LIVM]-[LIVMFY]-[GA]-x-[GA]-x-
                         G-[LIVMF]-x(2)-[SGA]-[LIVM]-x-[LIVMFYW]-G-x-N
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.94
            ExPASy - ENZYME nomenclature database: 1.1.1.94
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.94
            BRENDA, the Enzyme Database: 1.1.1.94
///
ENTRY       EC 1.1.1.95
NAME        Phosphoglycerate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Phosphoglycerate:NAD+ 2-oxidoreductase
REACTION    3-Phosphoglycerate + NAD+ = 3-Phosphohydroxypyruvate + NADH
SUBSTRATE   3-Phosphoglycerate
            NAD+
PRODUCT     3-Phosphohydroxypyruvate
            NADH
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b2913(serA)
            ECE: Z4251(serA)
            ECS: ECs3784
            YPE: YPO0914(serA)
            HIN: HI0465(serA)
            PMU: PM1671(serA)
            XFA: XF2206
            VCH: VC2481
            PAE: PA0316(serA)
            HPY: HP0096 HP0397(serA)
            HPJ: jhp0088 jhp0984
            CJE: Cj0891c(serA)
            MLO: mll1021 mll3875 mlr3367 mlr7269
            SME: SMc00641(serA)
            CCR: CC3215
            BSU: BG10509(serA) BG13475(yoaD)
            BHA: BH1602
            SAU: SA1545(serA)
            SAV: SAV1710(serA)
            LLA: L0084(serA)
            CAC: CAC0015(serA) CAC0089(serA)
            MTU: Rv0728c Rv2996c(serA)
            MTC: MT0753 MT3074
            MLE: ML1692(serA)
            SYN: sll1908(serA)
            DRA: DR1291
            AAE: aq_1905(serA)
            TMA: TM0327 TM1401
            MJA: MJ1018(serA)
            MTH: MTH970
            AFU: AF0813(serA)
            HAL: VNG2424G(serA1)
            PHO: PH0597 PH1387
            PAB: PAB0514(serA-like) PAB2374(gdh-like)
            APE: APE1831
            SSO: SSO0905(serA-1) SSO3187(serA-2)
            STO: ST0694 ST1218
            SCE: YER081W(SER3) YIL074C(SER33)
            SPO: SPCC4G3.01(spcc4g3.01)
            CEL: C31C9.2 F49E10.5
            DME: CG6287
            HSA: 26227(PHGDH)
MOTIF       PS: PS00065  [LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-
                         G-x(13,14)-[LIVMFT]-x(2)-[FYWCTH]-[DNSTK]
            PS: PS00670  [LIVMFYWA]-[LIVFYWC]-x(2)-[SAC]-[DNQHR]-[IVFA]-[LIVF]-
                         x-[LIVF]-[HNI]-x-P-x(4)-[STN]-x(2)-[LIVMF]-x-[GSDN]
            PS: PS00671  [LMFATC]-[KPQ]-x-[GSTDN]-x-[LIVMFYWR]-[LIVMFYW](2)-N-x-
                         [STAGC]-R-[GP]-x-[LIVH]-[LIVMC]-[DNV]
STRUCTURES  PDB: 1PSD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.95
            ExPASy - ENZYME nomenclature database: 1.1.1.95
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.95
            BRENDA, the Enzyme Database: 1.1.1.95
            SCOP (Structural Classification of Proteins): 1.1.1.95
///
ENTRY       EC 1.1.1.96
NAME        Diiodophenylpyruvate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-(3,5-Diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase
REACTION    3-(3,5-Diiodo-4-hydroxyphenyl)lactate + NAD+ =
            3-(3,5-Diiodo-4-hydroxyphenyl)pyruvate + NADH
SUBSTRATE   3-(3,5-Diiodo-4-hydroxyphenyl)lactate
            NAD+
PRODUCT     3-(3,5-Diiodo-4-hydroxyphenyl)pyruvate
            NADH
COMMENT     Substrates contain an aromatic ring with pyruvate side chain.
            The most active substrate are halogenated derivatives.  Compounds
            with hydroxyl or amino group in the 3 or 5 position are inactive.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.96
            ExPASy - ENZYME nomenclature database: 1.1.1.96
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.96
            BRENDA, the Enzyme Database: 1.1.1.96
///
ENTRY       EC 1.1.1.97
NAME        3-Hydroxybenzyl-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Hydroxybenzyl-alcohol:NADP+ oxidoreductase
REACTION    3-Hydroxybenzyl alcohol + NADP+ = 3-Hydroxybenzaldehyde + NADPH
SUBSTRATE   3-Hydroxybenzyl alcohol
            NADP+
PRODUCT     3-Hydroxybenzaldehyde
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.97
            ExPASy - ENZYME nomenclature database: 1.1.1.97
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.97
            BRENDA, the Enzyme Database: 1.1.1.97
///
ENTRY       EC 1.1.1.98
NAME        (R)-2-Hydroxy-fatty-acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-2-Hydroxystearate:NAD+ oxidoreductase
REACTION    (R)-2-Hydroxystearate + NAD+ = 2-Oxostearate + NADH
SUBSTRATE   (R)-2-Hydroxystearate
            NAD+
PRODUCT     2-Oxostearate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.98
            ExPASy - ENZYME nomenclature database: 1.1.1.98
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.98
            BRENDA, the Enzyme Database: 1.1.1.98
///
ENTRY       EC 1.1.1.99
NAME        (S)-2-Hydroxy-fatty-acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-2-Hydroxystearate:NAD+ oxidoreductase
REACTION    (S)-2-Hydroxystearate + NAD+ = 2-Oxostearate + NADH
SUBSTRATE   (S)-2-Hydroxystearate
            NAD+
PRODUCT     2-Oxostearate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.99
            ExPASy - ENZYME nomenclature database: 1.1.1.99
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.99
            BRENDA, the Enzyme Database: 1.1.1.99
///
ENTRY       EC 1.1.1.100
NAME        3-Oxoacyl-[acyl-carrier-protein] reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (3R)-3-Hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase
REACTION    (3R)-3-Hydroxyacyl-[acyl-carrier protein] + NADP+ =
            3-Oxoacyl-[acyl-carrier protein] + NADPH
SUBSTRATE   (3R)-3-Hydroxyacyl-[acyl-carrier protein]
            NADP+
            (3R)-3-Hydroxyacyl-CoA
PRODUCT     3-Oxoacyl-[acyl-carrier protein]
            NADPH
            3-Oxoacyl-CoA
COMMENT     Exhibits a marked preference for acyl-carrier-protein
            derivatives over CoA derivatives as substrates.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b1093(fabG)
            ECE: Z1732(fabG) Z4865
            ECS: ECs1471 ECs4340
            YPE: YPO1599(fabG)
            HIN: HI0155(fabG)
            PMU: PM1916(fabG)
            XFA: XF0173 XF0319 XF0671
            VCH: VC2021 VCA0691
            PAE: PA1470 PA2967(fabG) PA3387(rhlG) PA4389 PA5524
            BUC: BU351(fabG)
            NME: NMB1702 NMB1921
            NMA: NMA0533(fabG)
            HPY: HP0561(fabG)
            HPJ: jhp0508
            CJE: Cj0435(fabG)
            RPR: RP035(phbB) RP762(fabG)
            RCO: RC0054(phbB) RC1183(fabG)
            MLO: mll1017 mll1981 mlr0808 mlr3848 mlr6807 mlr7850
            SME: SMb21474 SMc00572(fabG)
            CCR: CC0511 CC1675 CC2836
            BSU: BG11535(fabG) BG13173(yjdA) BG13429(ymfI) BG13870(ytkK)
                 BG14030(yusR) BG14031(yusS) BG14063(yvaG) BG14144(yvrD)
            BHA: BH0506 BH0932 BH1842 BH2391 BH2491(fabG) BH3182 BH3896
            SAU: SA1074(fabG) SA1123
            SAV: SAV1218(fabG)
            LLA: L0185(fabG1) L27694(fabG2)
            SPY: SPy0440 SPy1749(fabG)
            SPN: SP0421 SP0793
            SPR: spr0381(fabG) spr0701(fabG)
            CAC: CAC2626(fabG) CAC3462(fabG) CAC3574(fabG)
            MTU: Rv0769 Rv1350(fabG2) Rv1483(fabG1) Rv3502c Rv3559c
            MTC: MT0793 MT1393 MT1530 MT3606 MT3664
            MLE: ML1807(fabG1)
            CTR: CT237
            CMU: TC0508
            CPN: CPn0296
            CPA: CP0462
            CPJ: fabG
            SYN: slr0886(fabG) slr1994(fabG)
            DRA: DR1943
            AAE: aq_1716(fabG)
            TMA: TM1169 TM1724
            HAL: VNG1341G(fabG) VNG2158G(oxrA)
            TAC: Ta0251 Ta0822
            TVO: TVG0720035 TVG1417421
            PHO: PH1901
            PAB: PAB1085(fabG) PAB2177
            APE: APE0912 APE2503
            SSO: SSO0975(fabG-1) SSO2276(fabG-5) SSO2289(fabG-6)
                 SSO2500(fabG-7) SSO3114(fabG-10)
            STO: ST0070 ST1109 ST1299
            SCE: YPL231W(FAS2)
            SPO: LSD1(lsd1)
            CEL: F09E10.3
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
STRUCTURES  PDB: 1I01  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.100
            ExPASy - ENZYME nomenclature database: 1.1.1.100
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.100
            BRENDA, the Enzyme Database: 1.1.1.100
            SCOP (Structural Classification of Proteins): 1.1.1.100
///
ENTRY       EC 1.1.1.101
NAME        Acylglycerone-phosphate reductase
            Palmitoyldihydroxyacetone-phosphate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1-Palmitoylglycerol-3-phosphate:NADP+ oxidoreductase
REACTION    1-Palmitoylglycerol 3-phosphate + NADP+ =
            Palmitoylglycerone phosphate + NADPH
SUBSTRATE   1-Palmitoylglycerol 3-phosphate
            NADP+
PRODUCT     Palmitoylglycerone phosphate
            NADPH
COMMENT     Also acts on alkylglycerone 3-phosphate and alkylglycerol
            3-phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.101
            ExPASy - ENZYME nomenclature database: 1.1.1.101
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.101
            BRENDA, the Enzyme Database: 1.1.1.101
///
ENTRY       EC 1.1.1.102
NAME        3-Dehydrosphinganine reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-erythro-Dihydrosphingosine:NADP+ 3-oxidoreductase
REACTION    Sphinganine + NADP+ = 3-Dehydrosphinganine + NADPH
SUBSTRATE   Sphinganine
            NADP+
PRODUCT     3-Dehydrosphinganine
            NADPH
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.102
            ExPASy - ENZYME nomenclature database: 1.1.1.102
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.102
            BRENDA, the Enzyme Database: 1.1.1.102
///
ENTRY       EC 1.1.1.103
NAME        L-Threonine 3-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Threonine:NAD+ oxidoreductase
REACTION    L-Threonine + NAD+ = L-2-Amino-3-oxobutanoate + NADH
SUBSTRATE   L-Threonine
            NAD+
PRODUCT     L-2-Amino-3-oxobutanoate
            NADH
COMMENT     The product spontaneously decarboxylates to aminoacetone
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b3616(tdh)
            ECE: Z5043(tdh)
            ECS: ECs4494
            YPE: YPO0060(tdh)
            VCH: VCA0885
            MLO: mlr8299
            SME: SMc01564(tdh)
            BSU: BG12685(tdh)
            DRA: DR1662
            PHO: PH0655
            PAB: PAB2382
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.103
            ExPASy - ENZYME nomenclature database: 1.1.1.103
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.103
            BRENDA, the Enzyme Database: 1.1.1.103
///
ENTRY       EC 1.1.1.104
NAME        4-Oxoproline reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Hydroxy-L-proline:NAD+ oxidoreductase
REACTION    4-Hydroxy-L-proline + NAD+ = 4-Oxoproline + NADH
SUBSTRATE   4-Hydroxy-L-proline
            NAD+
PRODUCT     4-Oxoproline
            NADH
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.104
            ExPASy - ENZYME nomenclature database: 1.1.1.104
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.104
            BRENDA, the Enzyme Database: 1.1.1.104
///
ENTRY       EC 1.1.1.105
NAME        Retinol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Retinol:NAD+ oxidoreductase
REACTION    Retinol + NAD+ = Retinal + NADH
SUBSTRATE   Retinol
            NAD+
PRODUCT     Retinal
            NADH
PATHWAY     PATH: MAP00830  Retinol metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.105
            ExPASy - ENZYME nomenclature database: 1.1.1.105
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.105
            BRENDA, the Enzyme Database: 1.1.1.105
///
ENTRY       EC 1.1.1.106
NAME        Pantoate 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Pantoate:NAD+ 4-oxidoreductase
REACTION    (R)-Pantoate + NAD+ = (R)-4-Dehydropantoate + NADH
SUBSTRATE   (R)-Pantoate
            NAD+
PRODUCT     (R)-4-Dehydropantoate
            NADH
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.106
            ExPASy - ENZYME nomenclature database: 1.1.1.106
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.106
            BRENDA, the Enzyme Database: 1.1.1.106
///
ENTRY       EC 1.1.1.107
NAME        Pyridoxal 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pyridoxal:NAD+ 4-oxidoreductase
REACTION    Pyridoxal + NAD+ = 4-Pyridoxolactone + NADH
SUBSTRATE   Pyridoxal
            NAD+
PRODUCT     4-Pyridoxolactone
            NADH
COMMENT     The enzyme acts on the hemiacetal form of the substrate.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.107
            ExPASy - ENZYME nomenclature database: 1.1.1.107
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.107
            BRENDA, the Enzyme Database: 1.1.1.107
///
ENTRY       EC 1.1.1.108
NAME        Carnitine 3-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Carnitine:NAD+ 3-oxidoreductase
REACTION    Carnitine + NAD+ = 3-Dehydrocarnitine + NADH
SUBSTRATE   Carnitine
            NAD+
PRODUCT     3-Dehydrocarnitine
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.108
            ExPASy - ENZYME nomenclature database: 1.1.1.108
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.108
            BRENDA, the Enzyme Database: 1.1.1.108
///
ENTRY       EC 1.1.1.109
NAME        Transferred to EC 1.3.1.28
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry.
            Now EC 1.3.1.28 - 2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.109
            ExPASy - ENZYME nomenclature database: 1.1.1.109
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.109
///
ENTRY       EC 1.1.1.110
NAME        Indolelactate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Indolelactate:NAD+ oxidoreductase
REACTION    Indolelactate + NAD+ = Indolepyruvate + NADH
SUBSTRATE   Indolelactate
            NAD+
PRODUCT     Indolepyruvate
            NADH
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.110
            ExPASy - ENZYME nomenclature database: 1.1.1.110
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.110
            BRENDA, the Enzyme Database: 1.1.1.110
///
ENTRY       EC 1.1.1.111
NAME        3-(Imidazol-5-yl)lactate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-3-(Imidazol-5-yl)lactate:NAD(P)+ oxidoreductase
REACTION    (S)-3-(Imidazol-5-yl)lactate + NAD+ or NADP+ =
            3-(Imidazol-5-yl)pyruvate + NADH or NADPH
SUBSTRATE   (S)-3-(Imidazol-5-yl)lactate
            NAD+
            NADP+
PRODUCT     3-(Imidazol-5-yl)pyruvate
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.111
            ExPASy - ENZYME nomenclature database: 1.1.1.111
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.111
            BRENDA, the Enzyme Database: 1.1.1.111
///
ENTRY       EC 1.1.1.112
NAME        Indanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Indan-1-ol:NAD(P)+ 1-oxidoreductase
REACTION    Indan-1-ol + NAD+ or NADP+ = Indanone + NADH or NADPH
SUBSTRATE   Indan-1-ol
            NAD+
            NADP+
PRODUCT     Indanone
            NADH
            NADPH
COMMENT     3(20)alpha-Hydroxysteroids are also oxidized, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.112
            ExPASy - ENZYME nomenclature database: 1.1.1.112
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.112
            BRENDA, the Enzyme Database: 1.1.1.112
///
ENTRY       EC 1.1.1.113
NAME        L-Xylose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Xylose:NADP+ 1-oxidoreductase
REACTION    L-Xylose + NADP+ = L-Xylono-1,4-lactone + NADPH
SUBSTRATE   L-Xylose
            NADP+
            D-Arabinose
            D-Lyxose
PRODUCT     L-Xylono-1,4-lactone
            NADPH
COMMENT     Also oxidizes D-arabinose and D-lyxose.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.113
            ExPASy - ENZYME nomenclature database: 1.1.1.113
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.113
            BRENDA, the Enzyme Database: 1.1.1.113
///
ENTRY       EC 1.1.1.114
NAME        Apiose 1-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Apiitol:NAD+ 1-oxidoreductase
REACTION    D-Apiitol + NAD+ = D-Apiose + NADH
SUBSTRATE   D-Apiitol
            NAD+
PRODUCT     D-Apiose
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.114
            ExPASy - ENZYME nomenclature database: 1.1.1.114
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.114
            BRENDA, the Enzyme Database: 1.1.1.114
///
ENTRY       EC 1.1.1.115
NAME        Ribose 1-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Ribose:NADP+ 1-oxidoreductase
REACTION    D-Ribose + NADP+ + H2O = D-Ribonate + NADPH
SUBSTRATE   D-Ribose
            NADP+
            H2O
PRODUCT     D-Ribonate
            NADPH
COMMENT     Also acts, more slowly, on D-xylose and other pentoses.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.115
            ExPASy - ENZYME nomenclature database: 1.1.1.115
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.115
            BRENDA, the Enzyme Database: 1.1.1.115
///
ENTRY       EC 1.1.1.116
NAME        D-Arabinose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Arabinose:NAD+ 1-oxidoreductase
REACTION    D-Arabinose + NAD+ = D-Arabinono-1,4-lactone + NADH
SUBSTRATE   D-Arabinose
            NAD+
PRODUCT     D-Arabinono-1,4-lactone
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.116
            ExPASy - ENZYME nomenclature database: 1.1.1.116
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.116
            BRENDA, the Enzyme Database: 1.1.1.116
///
ENTRY       EC 1.1.1.117
NAME        D-Arabinose 1-dehydrogenase (NAD(P)+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Arabinose:NAD(P)+ 1-oxidoreductase
REACTION    D-Arabinose + NAD+ or NADP+ = D-Arabinono-1,4-lactone +
            NADH or NADPH
SUBSTRATE   D-Arabinose
            NAD+
            NADP+
            L-Galactose
            6-Deoxy-L-galactose
            3,6-Dideoxy-L-galactose
PRODUCT     D-Arabinono-1,4-lactone
            NADH
            NADPH
COMMENT     Also acts on L-galactose, 6-deoxy- and 3,6-dideoxy-L-galactose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.117
            ExPASy - ENZYME nomenclature database: 1.1.1.117
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.117
            BRENDA, the Enzyme Database: 1.1.1.117
///
ENTRY       EC 1.1.1.118
NAME        Glucose 1-dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glucose:NAD+ 1-oxidoreductase
REACTION    D-Glucose + NAD+ = D-Glucono-1,5-lactone + NADH
SUBSTRATE   D-Glucose
            NAD+
PRODUCT     D-Glucono-1,5-lactone
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.118
            ExPASy - ENZYME nomenclature database: 1.1.1.118
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.118
            BRENDA, the Enzyme Database: 1.1.1.118
///
ENTRY       EC 1.1.1.119
NAME        Glucose 1-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glucose:NADP+ 1-oxidoreductase
REACTION    D-Glucose + NADP+ = D-Glucono-1,4-lactone + NADPH
SUBSTRATE   D-Glucose
            NADP+
            D-Mannose
            2-Deoxy-D-glucose
            2-Amino-2-deoxy-D-mannose
PRODUCT     D-Glucono-1,4-lactone
            NADPH
COMMENT     Also oxidizes D-mannose, 2-deoxy-D-glucose and 2-amino-2-deoxy-
            -D-mannose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.119
            ExPASy - ENZYME nomenclature database: 1.1.1.119
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.119
            BRENDA, the Enzyme Database: 1.1.1.119
///
ENTRY       EC 1.1.1.120
NAME        Galactose 1-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Galactose:NADP+ 1-oxidoreductase
REACTION    D-Galactose + NADP+ = D-Galactonolactone + NADPH
SUBSTRATE   D-Galactose
            NADP+
            L-Arabinose
            6-Deoxy-D-galactose
            2-Deoxy-D-galactose
PRODUCT     D-Galactonolactone
            NADPH
COMMENT     Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.120
            ExPASy - ENZYME nomenclature database: 1.1.1.120
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.120
            BRENDA, the Enzyme Database: 1.1.1.120
///
ENTRY       EC 1.1.1.121
NAME        Aldose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Aldose:NAD+ 1-oxidoreductase
REACTION    D-Aldose + NAD+ = D-Aldonolactone + NADH
SUBSTRATE   D-Aldose
            NAD+
            D-Glucose
            2-Deoxy-D-glucose
            6-Deoxy-D-glucose
            D-Galactose
            6-Deoxy-D-galactose
            2-Deoxy-L-arabinose
            D-Xylose
PRODUCT     D-Aldonolactone
            NADH
COMMENT     Acts on D-glucose, 2-deoxy- and 6-deoxy-D-glucose, D-galactose,
            6-deoxy-D-galactose, 2-deoxy-L-arabinose and D-xylose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.121
            ExPASy - ENZYME nomenclature database: 1.1.1.121
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.121
            BRENDA, the Enzyme Database: 1.1.1.121
///
ENTRY       EC 1.1.1.122
NAME        D-threo-Aldose 1-dehydrogenase
            L-Fucose dehydrogenase
            (2S,3R)-Aldose dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-threo-Aldose:NAD+ 1-oxidoreductase
REACTION    a D-threo-Aldose + NAD+ = a D-threo-Aldono-1,5-lactone + NADH
SUBSTRATE   D-threo-Aldose
            NAD+
            L-Fucose
            D-Arabinose
            L-Xylose
PRODUCT     D-threo-Aldono-1,5-lactone
            NADH
COMMENT     Acts on L-fucose, D-arabinose and L-xylose; the animal enzyme was
            also shown to act on L-arabinose, and the enzyme from Pseudomonas
            caryophylli on L-glucose.
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
GENES       MLO: mll8482 mlr3332
            SME: SMc02775
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.122
            ExPASy - ENZYME nomenclature database: 1.1.1.122
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.122
            BRENDA, the Enzyme Database: 1.1.1.122
///
ENTRY       EC 1.1.1.123
NAME        Sorbose 5-dehydrogenase (NADP+)
            5-Ketofructose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Sorbose:NADP+ 5-oxidoreductase
REACTION    L-Sorbose + NADP+ = 5-Dehydro-D-fructose + NADPH
SUBSTRATE   L-Sorbose
            NADP+
PRODUCT     5-Dehydro-D-fructose
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.123
            ExPASy - ENZYME nomenclature database: 1.1.1.123
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.123
            BRENDA, the Enzyme Database: 1.1.1.123
///
ENTRY       EC 1.1.1.124
NAME        Fructose 5-dehydrogenase (NADP+)
            5-Ketofructose reductase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Fructose:NADP+ 5-oxidoreductase
REACTION    D-Fructose + NADP+ = 5-Dehydro-D-fructose + NADPH
SUBSTRATE   D-Fructose
            NADP+
PRODUCT     5-Dehydro-D-fructose
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.124
            ExPASy - ENZYME nomenclature database: 1.1.1.124
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.124
            BRENDA, the Enzyme Database: 1.1.1.124
///
ENTRY       EC 1.1.1.125
NAME        2-Deoxy-D-gluconate 3-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Deoxy-D-gluconate:NAD+ 3-oxidoreductase
REACTION    2-Deoxy-D-gluconate + NAD+ = 3-Dehydro-2-deoxy-D-gluconate + NADH
SUBSTRATE   2-Deoxy-D-gluconate
            NAD+
PRODUCT     3-Dehydro-2-deoxy-D-gluconate
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b2842(kduD)
            ECE: Z4162(kduD)
            ECS: ECs3699
            YPE: YPO0839(kduD2) YPO1724(kduD1)
            MLO: mll4054
            SME: SMb21348
            CCR: CC1492
            BSU: BG11400(kduD)
            BHA: BH2167(kduD)
            CAC: CAC0361(kduD)
            MTU: Rv1714 Rv1928c
            MTC: MT1753.1
            AFU: AF1207(kduD)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.125
            ExPASy - ENZYME nomenclature database: 1.1.1.125
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.125
            BRENDA, the Enzyme Database: 1.1.1.125
///
ENTRY       EC 1.1.1.126
NAME        2-Dehydro-3-deoxy-D-gluconate 6-dehydrogenase
            2-Keto-3-deoxy-D-gluconate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase
REACTION    2-Dehydro-3-deoxy-D-gluconate + NADP+ =
            (4S,5S)-4,5-Dihydroxy-2,6-dioxohexanoate + NADPH
SUBSTRATE   2-Dehydro-3-deoxy-D-gluconate
            NADP+
PRODUCT     (4S,5S)-4,5-Dihydroxy-2,6-dioxohexanoate
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.126
            ExPASy - ENZYME nomenclature database: 1.1.1.126
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.126
            BRENDA, the Enzyme Database: 1.1.1.126
///
ENTRY       EC 1.1.1.127
NAME        2-Dehydro-3-deoxy-D-gluconate 5-dehydrogenase
            2-Keto-3-deoxygluconate 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase
REACTION    2-Dehydro-3-deoxy-D-gluconate + NAD+ =
            (4S)-4,6-Dihydroxy-2,5-dioxohexanoate + NADH
SUBSTRATE   2-Dehydro-3-deoxy-D-gluconate
            NAD+
PRODUCT     (4S)-4,6-Dihydroxy-2,5-dioxohexanoate
            NADH
COMMENT     The enzyme from Pseudononas acts equally well on NAD+ or NADP+,
            while those from Erwinia chrysanthemi and E. coli are more
            specific for NAD+.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.127
            ExPASy - ENZYME nomenclature database: 1.1.1.127
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.127
            BRENDA, the Enzyme Database: 1.1.1.127
///
ENTRY       EC 1.1.1.128
NAME        L-Idonate 2-dehydrogenase
            5-Ketogluconate 2-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Idonate:NADP+ 2-oxidoreductase
REACTION    L-Idonate + NADP+ = 5-Dehydro-D-gluconate + NADPH
SUBSTRATE   L-Idonate
            NADP+
PRODUCT     5-Dehydro-D-gluconate
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.128
            ExPASy - ENZYME nomenclature database: 1.1.1.128
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.128
            BRENDA, the Enzyme Database: 1.1.1.128
///
ENTRY       EC 1.1.1.129
NAME        L-Threonate 3-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Threonate:NAD+ 3-oxidoreductase
REACTION    L-Threonate + NAD+ = 3-Dehydro-L-threonate + NADH
SUBSTRATE   L-Threonate
            NAD+
PRODUCT     3-Dehydro-L-threonate
            NADH
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.129
            ExPASy - ENZYME nomenclature database: 1.1.1.129
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.129
            BRENDA, the Enzyme Database: 1.1.1.129
///
ENTRY       EC 1.1.1.130
NAME        3-Dehydro-L-gulonate 2-dehydrogenase
            3-Keto-L-gulonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase
REACTION    3-Dehydro-L-gulonate + NAD+ or NADP+ =
            (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate + NADH or NADPH
SUBSTRATE   3-Dehydro-L-gulonate
            NAD+
            NADP+
PRODUCT     (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
            NADH
            NADPH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.130
            ExPASy - ENZYME nomenclature database: 1.1.1.130
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.130
            BRENDA, the Enzyme Database: 1.1.1.130
///
ENTRY       EC 1.1.1.131
NAME        Mannuronate reductase
            Mannonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannonate:NAD(P)+ 6-oxidoreductase
REACTION    D-Mannonate + NAD+ or NADP+ = D-Mannuronate + NADH or NADPH
SUBSTRATE   D-Mannonate
            NAD+
            NADP+
PRODUCT     D-Mannuronate
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.131
            ExPASy - ENZYME nomenclature database: 1.1.1.131
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.131
            BRENDA, the Enzyme Database: 1.1.1.131
///
ENTRY       EC 1.1.1.132
NAME        GDPmannose 6-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     GDP-D-mannose:NAD+ 6-oxidoreductase
REACTION    GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH
SUBSTRATE   GDP-D-mannose
            NAD+
            H2O
PRODUCT     GDP-D-mannuronate
            NADH
COMMENT     Also acts on the corresponding deoxynucleoside diphosphate
            derivative as a substrate.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       PAE: PA3540(algD)
            MTH: MTH333
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.132
            ExPASy - ENZYME nomenclature database: 1.1.1.132
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.132
            BRENDA, the Enzyme Database: 1.1.1.132
///
ENTRY       EC 1.1.1.133
NAME        dTDP-4-dehydrorhamnose reductase
            dTDP-4-keto-L-rhamnose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase
REACTION    dTDP-6-deoxy-L-mannose + NADP+ =
            dTDP-4-dehydro-6-deoxy-L-mannose + NADPH
SUBSTRATE   dTDP-6-deoxy-L-mannose
            NADP+
PRODUCT     dTDP-4-dehydro-6-deoxy-L-mannose
            NADPH
COMMENT     In the reverse direction reduction on the 4-position of the
            hexose moiety takes place only while the substrate is bound to
            another enzyme which catalyses epimerization at C-3 and C-5; the
            complex has been referred to as dTDP-L-rhamnose synthase.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b2040(rfbD)
            XFA: XF0258
            PAE: PA5162(rmlD)
            NME: NMB0756
            NMA: NMA0967(rfbD)
            RPR: RP332
            MLO: mlr7553
            SME: SMb21327(expA10)
            CCR: CC1140 CC3615
            BSU: BG10619(spsK)
            BHA: BH3365(spsK)
            LLA: L320(rmlC)
            SPY: SPy0784(rmlD)
            SPR: spr0323(cpsO)
            CAC: CAC2315
            MTU: Rv3266c(rmlD)
            MTC: MT3366
            MLE: ML0751(rmlD)
            SYN: sll1395(rfbD)
            DRA: DRA0044
            MTH: MTH1792
            TVO: TVG0949121
            PHO: PH0417
            PAB: PAB0789
            APE: APE1179
            SSO: SSO0832(rfbD-1) SSO1783(rfbD-2) SSO2161(rfbD-3)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.133
            ExPASy - ENZYME nomenclature database: 1.1.1.133
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.133
            BRENDA, the Enzyme Database: 1.1.1.133
///
ENTRY       EC 1.1.1.134
NAME        dTDP-6-deoxy-L-talose 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase
REACTION    dTDP-6-deoxy-L-talose + NADP+ =
            dTDP-4-dehydro-6-deoxy-L-mannose + NADPH
SUBSTRATE   dTDP-6-deoxy-L-talose
            NADP+
PRODUCT     dTDP-4-dehydro-6-deoxy-L-mannose
            NADPH
COMMENT     Oxidation on the 4-position of the hexose moiety takes place only
            while the substrate is bound to another enzyme which catalyses
            epimerization at C-3 and C-5.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.134
            ExPASy - ENZYME nomenclature database: 1.1.1.134
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.134
            BRENDA, the Enzyme Database: 1.1.1.134
///
ENTRY       EC 1.1.1.135
NAME        GDP-6-deoxy-D-talose 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase
REACTION    GDP-6-deoxy-D-talose + NAD+ or NADP+ =
            GDP-4-dehydro-6-deoxy-D-talose + NADH or NADPH
SUBSTRATE   GDP-6-deoxy-D-talose
            NAD+
            NADP+
PRODUCT     GDP-4-dehydro-6-deoxy-D-talose
            NADH
            NADPH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.135
            ExPASy - ENZYME nomenclature database: 1.1.1.135
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.135
            BRENDA, the Enzyme Database: 1.1.1.135
///
ENTRY       EC 1.1.1.136
NAME        UDP-N-acetylglucosamine 6-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase
REACTION    UDP-N-acetyl-D-glucosamine + 2 NAD+ + H2O =
            UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            NAD+
            H2O
PRODUCT     UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
            NADH
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.136
            ExPASy - ENZYME nomenclature database: 1.1.1.136
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.136
            BRENDA, the Enzyme Database: 1.1.1.136
///
ENTRY       EC 1.1.1.137
NAME        Ribitol-5-phosphate 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase
REACTION    D-Ribitol 5-phosphate + NAD+ or NADP+ = D-Ribulose 5-phosphate +
            NADH or NADPH
SUBSTRATE   D-Ribitol 5-phosphate
            NAD+
            NADP+
PRODUCT     D-Ribulose 5-phosphate
            NADH
            NADPH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.137
            ExPASy - ENZYME nomenclature database: 1.1.1.137
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.137
            BRENDA, the Enzyme Database: 1.1.1.137
///
ENTRY       EC 1.1.1.138
NAME        Mannitol 2-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannitol:NADP+ 2-oxidoreductase
REACTION    D-Mannitol + NADP+ = D-Fructose + NADPH
SUBSTRATE   D-Mannitol
            NADP+
PRODUCT     D-Fructose
            NADPH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
STRUCTURES  PDB: 1H5Q  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.138
            ExPASy - ENZYME nomenclature database: 1.1.1.138
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.138
            BRENDA, the Enzyme Database: 1.1.1.138
///
ENTRY       EC 1.1.1.139
NAME        Deleted entry
            Polyol dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.1.1.21.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.139
            ExPASy - ENZYME nomenclature database: 1.1.1.139
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.139
///
ENTRY       EC 1.1.1.140
NAME        Sorbitol-6-phosphate 2-dehydrogenase
            Ketosephosphate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Dorbitol-6-phosphate:NAD+ 2-oxidoreductase
REACTION    D-Sorbitol 6-phosphate + NAD+ = D-Fructose 6-phosphate + NADH
SUBSTRATE   D-Sorbitol 6-phosphate
            NAD+
PRODUCT     D-Fructose 6-phosphate
            NADH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2705(srlD)
            ECE: Z4012(srlD) Z5618
            ECS: ECs3561 ECs5003
            PMU: PM1968
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.140
            ExPASy - ENZYME nomenclature database: 1.1.1.140
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.140
            BRENDA, the Enzyme Database: 1.1.1.140
///
ENTRY       EC 1.1.1.141
NAME        15-Hydroxyprostaglandin dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate:NAD+
            15-oxidoreductase
REACTION    (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate + NAD+ =
            (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate + NADH
SUBSTRATE   (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
            NAD+
            Prostaglandin E2
            Prostaglandin F2alpha
            Prostaglandin B1
PRODUCT     (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
            NADH
            Prostaglandin H2
            Prostaglandin E2
COMMENT     Acts on prostaglandin E2, F2alpha and B1, but not on
            prostaglandin D2 (cf. EC 1.1.1.196 and 1.1.1.197).
            The mammalian enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.141
            ExPASy - ENZYME nomenclature database: 1.1.1.141
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.141
            BRENDA, the Enzyme Database: 1.1.1.141
///
ENTRY       EC 1.1.1.142
NAME        D-Pinitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5D-5-O-Methyl-scyllo-inositol:NADP+ oxidoreductase
REACTION    5D-5-O-Methyl-scyllo-inositol + NADP+ =
            5D-5-O-Methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH
SUBSTRATE   5D-5-O-Methyl-scyllo-inositol
            NADP+
PRODUCT     5D-5-O-Methyl-2,3,5/4,6-pentahydroxycyclohexanone
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.142
            ExPASy - ENZYME nomenclature database: 1.1.1.142
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.142
            BRENDA, the Enzyme Database: 1.1.1.142
///
ENTRY       EC 1.1.1.143
NAME        Sequoyitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5-O-Methyl-myo-inositol:NAD+ oxidoreductase
REACTION    5-O-Methyl-myo-inositol + NAD+ =
            5D-5-O-Methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH
SUBSTRATE   5-O-Methyl-myo-inositol
            NAD+
PRODUCT     5D-5-O-Methyl-2,3,5/4,6-pentahydroxycyclohexanone
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.143
            ExPASy - ENZYME nomenclature database: 1.1.1.143
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.143
            BRENDA, the Enzyme Database: 1.1.1.143
///
ENTRY       EC 1.1.1.144
NAME        Perillyl-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Perillyl-alcohol:NAD+ oxidoreductase
REACTION    Perillyl alcohol + NAD+ = Perillyl aldehyde + NADH
SUBSTRATE   Perillyl alcohol
            NAD+
PRODUCT     Perillyl aldehyde
            NADH
COMMENT     Oxidizes a number of of primary alcohols with the alcohol group
            allylic to an endocyclic double bond and a 6-membered ring,
            either aromatic or hydroaromatic.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.144
            ExPASy - ENZYME nomenclature database: 1.1.1.144
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.144
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.144
            BRENDA, the Enzyme Database: 1.1.1.144
///
ENTRY       EC 1.1.1.145
NAME        3beta-Hydroxy-delta5-steroid dehydrogenase
            Progesterone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3beta-Hydroxy-delta5-steroid:NAD+ 3-oxidoreductase
REACTION    3beta-Hydroxy-delta5-steroid + NAD+ = 3-Oxo-delta5-steroid +
            NADH
SUBSTRATE   3beta-Hydroxy-delta5-steroid
            NAD+
            3beta-Hydroxyandrost-5-en-17-one
            3beta-Hydroxypregn-5-en-20-one
PRODUCT     3-Oxo-delta5-steroid
            NADH
            Androst-4-ene-3,17-dione
            Progesterone
COMMENT     Acts on 3beta-hydroxyandrost-5-en-17-one to form androst-4-ene-
            -3,17-dione and on 3beta-hydroxypregn-5-en-20-one to form
            progesterone.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
GENES       SCE: YGL001C(ERG26)
            SPO: SPBC3F6.02C(spbc3f6.02c)
            MMU: 96233(Hsd3b1) 96234(Hsd3b2) 96235(Hsd3b3) 96236(Hsd3b4)
            HSA: 3283(HSD3B1) 3284(HSD3B2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.145
            ExPASy - ENZYME nomenclature database: 1.1.1.145
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.145
            BRENDA, the Enzyme Database: 1.1.1.145
///
ENTRY       EC 1.1.1.146
NAME        11beta-Hydroxysteroid dehydrogenase
            Corticosteroid 11beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     11beta-Hydroxysteroid:NADP+ 11-oxidoreductase
REACTION    11beta-Hydroxysteroid + NADP+ = 11-Oxosteroid + NADPH
SUBSTRATE   11beta-Hydroxysteroid
            NADP+
PRODUCT     11-Oxosteroid
            NADPH
COMMENT     The mammalian enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
DISEASE     MIM: 218030  Hydroxysteroid (11-beta) dehydrogenase 2
            MIM: 600713  Hydroxysteroid, 11-beta, dehydrogenase 1
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.146
            ExPASy - ENZYME nomenclature database: 1.1.1.146
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.146
            BRENDA, the Enzyme Database: 1.1.1.146
///
ENTRY       EC 1.1.1.147
NAME        16alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     16alpha-Hydroxysteroid:NAD(P)+ 16-oxidoreductase
REACTION    a 16alpha-Hydroxysteroid + NAD+ or NADP+ = a 16-Oxosteroid +
            NADH or NADPH
SUBSTRATE   16alpha-Hydroxysteroid
            NAD+
            NADP+
PRODUCT     16-Oxosteroid
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.147
            ExPASy - ENZYME nomenclature database: 1.1.1.147
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.147
            BRENDA, the Enzyme Database: 1.1.1.147
///
ENTRY       EC 1.1.1.148
NAME        Estradiol 17alpha-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     17alpha-Hydroxysteroid:NAD(P)+ 17-oxidoreductase
REACTION    Estradiol-17alpha + NAD+ or NADP+ = Estrone + NADH or NADPH
SUBSTRATE   Estradiol-17alpha
            NAD+
            NADP+
PRODUCT     Estrone
            NADH
            NADPH
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.148
            ExPASy - ENZYME nomenclature database: 1.1.1.148
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.148
            BRENDA, the Enzyme Database: 1.1.1.148
///
ENTRY       EC 1.1.1.149
NAME        20alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     20alpha-Hydroxysteroid:NAD(P)+ 20-oxidoreductase
REACTION    17alpha,20alpha-Dihydroxypregn-4-en-3-one + NAD+ or NADP+ =
            17alpha-Hydroxyprogesterone + NADH or NADPH
SUBSTRATE   17alpha,20alpha-Dihydroxypregn-4-en-3-one
            NADP+
            NAD+
PRODUCT     17alpha-Hydroxyprogesterone
            NADPH
            NADH
COMMENT     A-specific with respect to NAD(P)+ (cf. EC 1.1.1.62).
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.149
            ExPASy - ENZYME nomenclature database: 1.1.1.149
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.149
            BRENDA, the Enzyme Database: 1.1.1.149
///
ENTRY       EC 1.1.1.150
NAME        21-Hydroxysteroid dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     21-Hydroxysteroid:NAD+ 21-oxidoreductase
REACTION    Pregnan-21-ol + NAD+ = Pregnan-21-al + NADH
SUBSTRATE   Pregnan-21-ol
            NAD+
PRODUCT     Pregnan-21-al
            NADH
COMMENT     Acts on a number of 21-hydroxycorticosteroids.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.150
            ExPASy - ENZYME nomenclature database: 1.1.1.150
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.150
            BRENDA, the Enzyme Database: 1.1.1.150
///
ENTRY       EC 1.1.1.151
NAME        21-Hydroxysteroid dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     21-Hydroxysteroid:NADP+ 21-oxidoreductase
REACTION    Pregnan-21-ol + NADP+ = Pregnan-21-al + NADPH
SUBSTRATE   Pregnan-21-ol
            NADP+
PRODUCT     Pregnan-21-al
            NADPH
COMMENT     Acts on a number of 21-hydroxycorticosteroids.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.151
            ExPASy - ENZYME nomenclature database: 1.1.1.151
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.151
            BRENDA, the Enzyme Database: 1.1.1.151
///
ENTRY       EC 1.1.1.152
NAME        3alpha-Hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
            Etiocholanolone 3alpha-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha-Hydroxy-5beta-steroid:NAD+ 3-oxidoreductase
REACTION    3alpha-Hydroxy-5beta-androstan-17-one + NAD+ =
            5beta-Androstane-3,17-dione + NADH
SUBSTRATE   3alpha-Hydroxy-5beta-androstan-17-one
            NAD+
PRODUCT     5beta-Androstane-3,17-dione
            NADH
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.152
            ExPASy - ENZYME nomenclature database: 1.1.1.152
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.152
            BRENDA, the Enzyme Database: 1.1.1.152
///
ENTRY       EC 1.1.1.153
NAME        Sepiapterin reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     7,8-Dihydrobiopterin:NADP+ oxidoreductase
REACTION    7,8-Dihydrobiopterin + NADP+ = Sepiapterin + NADPH
SUBSTRATE   7,8-Dihydrobiopterin
            NADP+
PRODUCT     Sepiapterin
            NADPH
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       SYN: sll0330
            DME: CG12117(Sptr)
            HSA: 6697(SPR)
STRUCTURES  PDB: 1NAS  1OAA  1SEP  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.153
            ExPASy - ENZYME nomenclature database: 1.1.1.153
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.153
            BRENDA, the Enzyme Database: 1.1.1.153
            SCOP (Structural Classification of Proteins): 1.1.1.153
///
ENTRY       EC 1.1.1.154
NAME        Ureidoglycolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Ureidoglycolate:NAD(P)+ oxidoreductase
REACTION    (S)-Ureidoglycolate + NAD+ or NADP+ = Oxalureate + NADH or NADPH
SUBSTRATE   (S)-Ureidoglycolate
            NAD+
            NADP+
PRODUCT     Oxalureate
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.154
            ExPASy - ENZYME nomenclature database: 1.1.1.154
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.154
            BRENDA, the Enzyme Database: 1.1.1.154
///
ENTRY       EC 1.1.1.155
NAME        Homoisocitrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-1-Hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase
REACTION    (-)-1-Hydroxy-1,2,4-butanetricarboxylate + NAD+ =
            2-Oxoadipate + CO2 + NADH
SUBSTRATE   (-)-1-Hydroxy-1,2,4-butanetricarboxylate
            NAD+
PRODUCT     2-Oxoadipate
            CO2
            NADH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.155
            ExPASy - ENZYME nomenclature database: 1.1.1.155
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.155
            BRENDA, the Enzyme Database: 1.1.1.155
///
ENTRY       EC 1.1.1.156
NAME        Glycerol 2-dehydrogenase (NADP+)
            Dihydroxyacetone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycerol:NADP+ 2-oxidoreductase
REACTION    Glycerol + NADP+ = Glycerone + NADPH
SUBSTRATE   Glycerol
            NADP+
PRODUCT     Glycerone
            NADPH
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.156
            ExPASy - ENZYME nomenclature database: 1.1.1.156
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.156
            BRENDA, the Enzyme Database: 1.1.1.156
///
ENTRY       EC 1.1.1.157
NAME        3-Hydroxybutyryl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-3-Hydroxybutanoyl-CoA:NADP+ oxidoreductase
REACTION    (S)-3-Hydroxybutanoyl-CoA + NADP+ = Acetoacetyl-CoA + NADPH
SUBSTRATE   (S)-3-Hydroxybutanoyl-CoA
            NADP+
PRODUCT     Acetoacetyl-CoA
            NADPH
PATHWAY     PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1395(ydbU)
            PAE: PA1628 PA3590
            MLO: mlr3490
            SME: SMc00727(hbdA)
            CCR: CC0715
            BSU: BG11320(mmgB)
            BHA: BH0204(hbd) BH1995 BH3800(mmgB)
            CAC: CAC2708(hbd)
            MTU: Rv1715(fadB3)
            MTC: MT1754
            DRA: DR1068
            TAC: Ta0947
            TVO: TVG1148597
            SSO: SSO0647(hdb-1) SSO2871(hdb-2) SSO2996(hdb-3)
MOTIF       PS: PS00067  [DNE]-x(2)-[GA]-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-
                         [LIVMFY](2)-x(5)-[LIVMFYCT]-[LIVMFY]-x(2)-[GV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.157
            ExPASy - ENZYME nomenclature database: 1.1.1.157
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.157
            BRENDA, the Enzyme Database: 1.1.1.157
///
ENTRY       EC 1.1.1.158
NAME        UDP-N-acetylmuramate dehydrogenase
            UDP-N-acetylenolpyruvoylglucosamine reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     UDP-N-acetylmuramate:NADP+ oxidoreductase
REACTION    UDP-N-acetylmuramate + NADP+ =
            UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH
SUBSTRATE   UDP-N-acetylmuramate
            NADP+
PRODUCT     UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine
            NADPH
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Sodium dithionite, sodium borohydride and,
            to lesser extent, NADH, can replace NADPH.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3972(murB)
            ECE: Z5543(murB)
            ECS: ECs4899
            YPE: YPO3760(murB)
            HIN: HI0268(murB)
            PMU: PM1589(murB)
            XFA: XF2572
            VCH: VC0318
            PAE: PA2977(murB)
            BUC: BU045(murB)
            NME: NMB0811
            NMA: NMA1021(murB)
            HPY: HP1418(murB)
            HPJ: jhp1313
            CJE: Cj1676(murB)
            RPR: RP248(murB)
            RCO: RC0332(murB)
            MLO: mll1552
            SME: SMc01868(murB)
            CCR: CC2545
            BSU: BG10228(murB)
            BHA: BH2564(murB)
            SAU: SA0693
            SAV: SAV0725
            LLA: L173881(murB)
            SPY: SPy1101(murB)
            SPN: SP1390
            SPR: spr1247(murB)
            CAC: CAC0510(murB)
            MTU: Rv0482(murB)
            MTC: MT0500
            MLE: ML2447(murB)
            CTR: CT831
            CMU: TC0218
            CPN: CPn0988
            CPA: CP0867
            CPJ: murB
            BBU: BB0598(murB)
            TPA: TP0090
            SYN: slr1424
            DRA: DR0628
            AAE: aq_520(murB1)
            TMA: TM1714
STRUCTURES  PDB: 1MBB  1MBT  1UXY  2MBR  1HSK  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.158
            ExPASy - ENZYME nomenclature database: 1.1.1.158
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.158
            BRENDA, the Enzyme Database: 1.1.1.158
            SCOP (Structural Classification of Proteins): 1.1.1.158
///
ENTRY       EC 1.1.1.159
NAME        7alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     7alpha-Hydroxysteroid:NAD+ 7-oxidoreductase
REACTION    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NAD+ =
            3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate + NADH
SUBSTRATE   3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
            NAD+
            NADP+
PRODUCT     3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholanate
            NADH
            NADPH
COMMENT     Catalyses the oxidation of the 7alpha-hydroxyl group of bile
            acids and alcohols both in their free and conjugated forms.
            The Bacteroides fragillis and Clostridium enzymes can also
            utilize NADP+.
            The mammalian enzyme is a member of the nonmetallo-short-chain
            alcohol dehydrogenase (ADH) family (Proc.Natl.Acad.Sci.USA(1991)
            88, 10064-10068).
GENES       ECO: b1619(hdhA)
            ECE: Z2624(hdhA)
            ECS: ECs2327
            HPY: HP1014(hdhA)
            HPJ: jhp0409
            MTU: Rv0927c
            MTC: MT0954
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1AHH  1AHI  1FMC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.159
            ExPASy - ENZYME nomenclature database: 1.1.1.159
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.159
            BRENDA, the Enzyme Database: 1.1.1.159
            SCOP (Structural Classification of Proteins): 1.1.1.159
///
ENTRY       EC 1.1.1.160
NAME        Dihydrobunolol dehydrogenase
            Bunolol reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+/-)-5-[(tert-Butylamino)-2'-hydroxypropoxyl]-1,2,3,4-
            $tetrahydro-1-naphthol:NADP+ oxidoreductase
REACTION    (+/-)-5-[(tert-Butylamino)-2'-hydroxypropoxyl]-1,2,3,4-
            $tetrahydro-1-naphthol + NADP+ =
            (+/-)-5-[(tert-Butylamino)-2'-hydroxypropoxyl]-3,4-
            $dihydro-1(2H)-naphthalenone + NADPH
SUBSTRATE   (+/-)-5-[(tert-Butylamino)-2'-hydroxypropoxyl]-1,2,3,4-
            $tetrahydro-1-naphthol
            NADP+
PRODUCT     (+/-)-5-[(tert-Butylamino)-2'-hydroxypropoxyl]-3,4-
            $dihydro-1(2H)-naphthalenone
            NADPH
COMMENT     Also acts, more slowly, with NAD+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.160
            ExPASy - ENZYME nomenclature database: 1.1.1.160
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.160
            BRENDA, the Enzyme Database: 1.1.1.160
///
ENTRY       EC 1.1.1.161
NAME        Cholestanetetraol 26-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-
            $oxidoreductase
REACTION    5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol + NAD+ =
            3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al + NADH
SUBSTRATE   5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol
            NAD+
PRODUCT     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al
            NADH
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.161
            ExPASy - ENZYME nomenclature database: 1.1.1.161
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.161
            BRENDA, the Enzyme Database: 1.1.1.161
///
ENTRY       EC 1.1.1.162
NAME        Erythrulose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Erythritol:NADP+ oxidoreductase
REACTION    Erythritol + NADP+ = D-Erythrulose + NADPH
SUBSTRATE   Erythritol
            NADP+
PRODUCT     D-Erythrulose
            NADPH
COMMENT     NAD+ is also utilized, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.162
            ExPASy - ENZYME nomenclature database: 1.1.1.162
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.162
            BRENDA, the Enzyme Database: 1.1.1.162
///
ENTRY       EC 1.1.1.163
NAME        Cyclopentanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cyclopentanol:NAD+ oxidoreductase
REACTION    Cyclopentanol + NAD+ = Cyclopentanone + NADH
SUBSTRATE   Cyclopentanol
            NAD+
PRODUCT     Cyclopentanone
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.163
            ExPASy - ENZYME nomenclature database: 1.1.1.163
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.163
            BRENDA, the Enzyme Database: 1.1.1.163
///
ENTRY       EC 1.1.1.164
NAME        Hexadecanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hexadecanol:NAD+ oxidoreductase
REACTION    Hexadecanol + NAD+ = Hexadecanal + NADH
SUBSTRATE   Hexadecanol
            NAD+
PRODUCT     Hexadecanal
            NADH
COMMENT     The  liver enzyme acts on long-chain alcohols from C8 to C16.
            The Euglena enzyme also oxidizes the corresponding aldehydes
            to fatty acids
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.164
            ExPASy - ENZYME nomenclature database: 1.1.1.164
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.164
            BRENDA, the Enzyme Database: 1.1.1.164
///
ENTRY       EC 1.1.1.165
NAME        2-Alkyn-1-ol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Butyne-1,4-diol:NAD+ 1-oxidoreductase
REACTION    2-Butyne-1,4-diol + NAD+ = 4-Hydroxy-2-butynal + NADH
SUBSTRATE   2-Butyne-1,4-diol
            NAD+
PRODUCT     4-Hydroxy-2-butynal
COMMENT     Acts on variety of 2-alkyn-1-ols, and also 1,4-butanediol.
            NADP+ also acts as acceptor, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.165
            ExPASy - ENZYME nomenclature database: 1.1.1.165
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.165
            BRENDA, the Enzyme Database: 1.1.1.165
///
ENTRY       EC 1.1.1.166
NAME        Hydroxycyclohexanecarboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (1S,3R,4S)-3,4-Dihydroxycyclohexane-1-carboxylate:NAD+
            $ 3-oxidoreductase
REACTION    (1S,3R,4S)-3,4-Dihydroxycyclohexane-1-carboxylate + NAD+
            (1S,4S)-4-Hydroxy-3-oxocyclohexane-1-carboxylate + NADH
SUBSTRATE   (1S,3R,4S)-3,4-Dihydroxycyclohexane-1-carboxylate
            NAD+
PRODUCT     (1S,4S)-4-Hydroxy-3-oxocyclohexane-1-carboxylate
            NADH
COMMENT     Acts on hydroxycyclohaxanecarboxylates having an equatorial
            carboxyl group at C-1, an axial hydroxyl group at C-3 and an
            equatorial hydroxyl or carbonyl group at C-4, including
            (-)-quinate and (-)-shikimate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.166
            ExPASy - ENZYME nomenclature database: 1.1.1.166
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.166
            BRENDA, the Enzyme Database: 1.1.1.166
///
ENTRY       EC 1.1.1.167
NAME        Hydroxymalonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hydroxymalonate:NAD+ oxidoreductase
REACTION    Hydroxymalonate + NAD+ = Oxomalonate + NADH
SUBSTRATE   Hydroxymalonate
            NAD+
PRODUCT     Oxomalonate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.167
            ExPASy - ENZYME nomenclature database: 1.1.1.167
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.167
            BRENDA, the Enzyme Database: 1.1.1.167
///
ENTRY       EC 1.1.1.168
NAME        2-Dehydropantoyl-lactone reductase (A-specific)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Pantoyl-lactone:NADP+ oxidoreductase (A-specific)
REACTION    (R)-Pantoyl lactone + NADP+ = 2-Dehydropantoyl lactone + NADPH
SUBSTRATE   (R)-Pantoyl lactone
            NADP+
PRODUCT     2-Dehydropantoyl lactone
            NADPH
COMMENT     The yeast enzyme is A-specific with respect to NADP+, in contrast
            with the enzyme from E. coli (EC 1.1.1.214).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.168
            ExPASy - ENZYME nomenclature database: 1.1.1.168
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.168
            BRENDA, the Enzyme Database: 1.1.1.168
///
ENTRY       EC 1.1.1.169
NAME        2-Dehydropantoate 2-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Pantoate:NADP+ 2-oxidoreductase
REACTION    (R)-Pantoate + NADP+ = 2-Dehydropantoate + NADPH
SUBSTRATE   (R)-Pantoate
            NADP+
PRODUCT     2-Dehydropantoate
            NADPH
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b0425(apbA)
            ECE: Z0528(apbA)
            ECS: ECs0479
            YPE: YPO3171(apbA)
            VCH: VC2307
            PAE: PA4397
            BSU: BG13369(ylbQ)
            BHA: BH2579(apbA)
            SAU: SA2232 SA2393
            SAV: SAV2427 SAV2584
            LLA: L157055(panE)
            SPY: SPy0852(apbA)
            CAC: CAC2937
            AAE: aq_1727
            AFU: AF1695(apbA)
            HAL: VNG0730C
            PHO: PH1390
            PAB: PAB0512(apbA)
            APE: APE0677
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.169
            ExPASy - ENZYME nomenclature database: 1.1.1.169
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.169
            BRENDA, the Enzyme Database: 1.1.1.169
///
ENTRY       EC 1.1.1.170
NAME        3beta-Hydroxy-4alpha-methylcholestenecarboxylate
            $ 3-dehydrogenase (decarboxylating)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3beta-Hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-
            $carboxylate:NAD+ 3-oxidoreductase (decarboxylating)
REACTION    3beta-Hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-
            $carboxylate + NAD+ =
            4alpha-Methyl-5alpha-cholest-7-en-3-one + CO2 + NADH
SUBSTRATE   3beta-Hydroxy-4alpha-methyl-5alpha-cholest-7-ene-4beta-
            $carboxylate
            NAD+
            3beta-Hydroxy-5alpha-cholest-7-ene-4alpha-carboxylate
PRODUCT     4alpha-Methyl-5alpha-cholest-7-en-3-one
            CO2
            NADH
COMMENT     The stereochemistry at C-4 is reversed during decarboxylation.
            Also acts on
            3beta-hydroxy-5alpha-cholest-7-ene-4alpha-carboxylate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.170
            ExPASy - ENZYME nomenclature database: 1.1.1.170
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.170
            BRENDA, the Enzyme Database: 1.1.1.170
///
ENTRY       EC 1.1.1.171
NAME        Transferred to EC 1.5.1.20
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.5.1.20 - Methylenetetrahydrofolate
            reductase (NADPH).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.171
            ExPASy - ENZYME nomenclature database: 1.1.1.171
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.171
///
ENTRY       EC 1.1.1.172
NAME        2-Oxoadipate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Hydroxyadipate:NAD+ 2-oxidoreductase
REACTION    2-Hydroxyadipate + NAD+ = 2-Oxoadipate + NADH
SUBSTRATE   2-Hydroxyadipate
            NAD+
PRODUCT     2-Oxoadipate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.172
            ExPASy - ENZYME nomenclature database: 1.1.1.172
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.172
            BRENDA, the Enzyme Database: 1.1.1.172
///
ENTRY       EC 1.1.1.173
NAME        L-Rhamnose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Rhamnofuranose:NAD+ 1-oxidoreductase
REACTION    L-Rhamnofuranose + NAD+ = L-Rhamno-1,4-lactone + NADH
SUBSTRATE   L-Rhamnofuranose
            NAD+
PRODUCT     L-Rhamno-1,4-lactone
            NADH
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.173
            ExPASy - ENZYME nomenclature database: 1.1.1.173
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.173
            BRENDA, the Enzyme Database: 1.1.1.173
///
ENTRY       EC 1.1.1.174
NAME        Cyclohexane-1,2-diol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     trans-Cyclohexane-1,2-diol:NAD+ 1-oxidoreductase
REACTION    trans-Cyclohexane-1,2-diol + NAD+ = 2-Hydroxycyclohexan-1-one +
            NADH
SUBSTRATE   trans-Cyclohexane-1,2-diol
            NAD+
PRODUCT     2-Hydroxycyclohexan-1-one
            NADH
COMMENT     Also oxidizes, more slowly, the cis isomer and 2-hydroxy-
            cyclohexanone.
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.174
            ExPASy - ENZYME nomenclature database: 1.1.1.174
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.174
            BRENDA, the Enzyme Database: 1.1.1.174
///
ENTRY       EC 1.1.1.175
NAME        D-Xylose 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Xylose:NAD+ 1-oxidoreductase
REACTION    D-Xylose + NAD+ = D-Xylonolactone + NADH
SUBSTRATE   D-Xylose
            NAD+
PRODUCT     D-Xylonolactone
            NADH
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.175
            ExPASy - ENZYME nomenclature database: 1.1.1.175
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.175
            BRENDA, the Enzyme Database: 1.1.1.175
///
ENTRY       EC 1.1.1.176
NAME        12alpha-hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     12alpha-Hydroxysteroid:NADP+ 12-oxidoreductase
REACTION    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + NADP+ =
            3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + NADPH
SUBSTRATE   3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
            NADP+
PRODUCT     3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate
            NADPH
COMMENT     Catalyses the oxidation of the 12alpha-hydroxyl group of bile
            acids, both in their free and conjugated form.  Also acts on
            bile alcohols.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.176
            ExPASy - ENZYME nomenclature database: 1.1.1.176
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.176
            BRENDA, the Enzyme Database: 1.1.1.176
///
ENTRY       EC 1.1.1.177
NAME        Glycerol-3-phosphate 1-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     sn-Glycerol-3-phosphate:NADP+ 1-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + NADP+ = D-Glyceraldehyde 3-phosphate +
            NADPH
SUBSTRATE   sn-Glycerol 3-phosphate
            NADP+
PRODUCT     D-Glyceraldehyde 3-phosphate
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.177
            ExPASy - ENZYME nomenclature database: 1.1.1.177
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.177
            BRENDA, the Enzyme Database: 1.1.1.177
///
ENTRY       EC 1.1.1.178
NAME        3-Hydroxy-2-methylbutyryl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
REACTION    (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ =
            2-Methylacetoacetyl-CoA + NADH
SUBSTRATE   (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
            NAD+
PRODUCT     2-Methylacetoacetyl-CoA
            NADH
COMMENT     Also acts, more slowly, on
            (2S,3S)-2-hydroxy-3-methylpentanoyl-CoA.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.178
            ExPASy - ENZYME nomenclature database: 1.1.1.178
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.178
            BRENDA, the Enzyme Database: 1.1.1.178
///
ENTRY       EC 1.1.1.179
NAME        D-Xylose 1-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Xylose:NADP+ 1-oxidoreductase
REACTION    D-Xylose + NADP+ = D-Xylono-1,5-lactone + NADPH
SUBSTRATE   D-Xylose
            NADP+
PRODUCT     D-Xylono-1,5-lactone
            NADPH
COMMENT     Also acts, more slowly, on L-arabinose and D-ribose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.179
            ExPASy - ENZYME nomenclature database: 1.1.1.179
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.179
            BRENDA, the Enzyme Database: 1.1.1.179
///
ENTRY       EC 1.1.1.180
NAME        Deleted entry
            Mannonate dehydrogenase (NAD(P)+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.1.1.131.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.180
            ExPASy - ENZYME nomenclature database: 1.1.1.180
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.180
///
ENTRY       EC 1.1.1.181
NAME        Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase
            3beta-Hydroxy-delta5-C27-steroid oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase
REACTION    Cholest-5-ene-3beta,7alpha-diol + NAD+ =
            7-Hydroxycholest-4-en-3-one + NADH
SUBSTRATE   Cholest-5-ene-3beta,7alpha-diol
            NAD+
PRODUCT     7-Hydroxycholest-4-en-3-one
            NADH
COMMENT     Highly specific for 3beta-hydroxy-C27-steroids with
            delta5-double bond.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.181
            ExPASy - ENZYME nomenclature database: 1.1.1.181
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.181
            BRENDA, the Enzyme Database: 1.1.1.181
///
ENTRY       EC 1.1.1.182
NAME        Deleted entry
            Fenchol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.1.1.198, 1.1.1.227 and
            1.1.1.228.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.182
            ExPASy - ENZYME nomenclature database: 1.1.1.182
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.182
            BRENDA, the Enzyme Database: 1.1.1.182
///
ENTRY       EC 1.1.1.183
NAME        Geraniol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Geraniol:NADP+ oxidoreductase
REACTION    Geraniol + NADP+ = Geranial + NADPH
SUBSTRATE   Geraniol
            NADP+
PRODUCT     Geranial
            NADPH
COMMENT     Also acts, more slowly, on nerol, farnesol and citronellol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.183
            ExPASy - ENZYME nomenclature database: 1.1.1.183
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.183
            BRENDA, the Enzyme Database: 1.1.1.183
///
ENTRY       EC 1.1.1.184
NAME        Carbonyl reductase (NADPH)
            Aldehyde reductase I
            Prostaglandin 9-ketoreductase
            Xenobiotic ketone reductase
            NADPH-dependent carbonyl reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Secondary-alcohol:NADP+ oxidoreductase
REACTION    R-CHOH-R' + NADP+ = R-CO-R' + NADPH
SUBSTRATE   R-CHOH-R'
            NADP+
            Hydroquinone
            Aromatic alcohol
            Hydroxyaldehyde
            Prostaglandin F2alpha
PRODUCT     R-CO-R'
            NADPH
            Quinone
            Aromatic aldehyde
            Ketoaldehyde
            Prostaglandin E2
COMMENT     Acts on wide range of carbonyl compounds, including quinones,
            aromatic aldehydes, ketoaldehydes, daunorubicin, and
            prostaglandins E and F, reducing them to the corresponding
            alcohol. B-specific with respect to NADPH (cf. EC 1.1.1.2).
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       CEL: R11D1.11
            DME: CG7322
            HSA: 873(CBR1) 874(CBR3)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1CYD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.184
            ExPASy - ENZYME nomenclature database: 1.1.1.184
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.184
            BRENDA, the Enzyme Database: 1.1.1.184
            SCOP (Structural Classification of Proteins): 1.1.1.184
///
ENTRY       EC 1.1.1.185
NAME        L-Glycol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glycol:NAD(P)+ oxidoreductase
REACTION    an L-Glycol + NAD+ or NADP+ = a 2-Hydroxycarbonyl compound +
            NADH or NADPH
SUBSTRATE   L-Glycol
            NAD+
            NADP+
PRODUCT     2-Hydroxycarbonyl compound
            NADH
            NADPH
COMMENT     The 2-hydroxycarbonyl compound formed can be further oxidized to
            a vicinal dicarbonyl compound.  In the reverse direction, vicinal
            diketones, glyceraldehyde, glyoxal, methylglyoxal,
            2-oxohydroxyketones and 2-ketoacid esters can be reduced.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.185
            ExPASy - ENZYME nomenclature database: 1.1.1.185
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.185
            BRENDA, the Enzyme Database: 1.1.1.185
///
ENTRY       EC 1.1.1.186
NAME        dTDPgalactose 6-dehydrogenase
            Thymidine-diphosphate-galactose dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     dTDP-D-galactose:NAD+ 6-oxidoreductase
REACTION    dTDP-D-galactose + 2 NAD+ + H2O = dTDP-D-galacturonate + 2 NADH
SUBSTRATE   dTDP-D-galactose
            NAD+
            H2O
PRODUCT     dTDP-D-galacturonate
            NADH
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.186
            ExPASy - ENZYME nomenclature database: 1.1.1.186
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.186
            BRENDA, the Enzyme Database: 1.1.1.186
///
ENTRY       EC 1.1.1.187
NAME        GDP-4-dehydro-D-rhamnose reductase
            GDP-4-keto-6-deoxy-D-mannose reductase
            GDP-4-keto-D-rhamnose reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase
REACTION    GDP-6-deoxy-D-mannose + NAD+ or NADP+ =
            GDP-4-dehydro-6-deoxy-D-mannose + NADH or NADPH
SUBSTRATE   GDP-6-deoxy-D-mannose
            NAD+
            NADP+
PRODUCT     GDP-4-dehydro-6-deoxy-D-mannose
            NADH
            NADPH
COMMENT     In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4
            epimer is formed.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.187
            ExPASy - ENZYME nomenclature database: 1.1.1.187
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.187
            BRENDA, the Enzyme Database: 1.1.1.187
///
ENTRY       EC 1.1.1.188
NAME        Prostaglandin-F synthase
            Prostaglandin-D2 11-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate:
            NADP+ 11-oxidoreductase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate +
            NADP+ =
            (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
            + NADPH
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
            NADP+
            Prostaglandin D2
            Prostaglandin H2
            9,10-Phenanthroquinone
            4-Nitroacetophenone
PRODUCT     (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
            NADPH
            Prostaglandin F2
COMMENT     Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2;
            prostaglandin D2 is not an intermediate in the reduction of
            prostaglandin H2. Also catalyses the reduction of a number of
            carbonyl compounds, such as 9,10-phenanthroquinone and
            4-nitroacetophenone.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.188
            ExPASy - ENZYME nomenclature database: 1.1.1.188
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.188
            BRENDA, the Enzyme Database: 1.1.1.188
///
ENTRY       EC 1.1.1.189
NAME        Prostaglandin-E2 9-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate:
            $NADP+ 9-oxidoreductase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate +
            NADP+ =
            (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate +
            NADPH
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate
            NADP+
            Prostaglandin E2
PRODUCT     (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
            NADPH
            Prostaglandin F2alpha
COMMENT     Reduces prostaglandin E2 to prostaglandin F2alpha.  A number of
            other 9-oxo- and 15-oxo-prostaglandin derivatives can also be
            reduced to the corresponding hydroxy compounds.  May be identical
            with EC 1.1.1.197.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: 873(CBR1)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.189
            ExPASy - ENZYME nomenclature database: 1.1.1.189
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.189
            BRENDA, the Enzyme Database: 1.1.1.189
///
ENTRY       EC 1.1.1.190
NAME        Indole-3-acetaldehyde reductase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Indole-3-ethanol:NAD+ oxidoreductase
REACTION    Indole-3-ethanol + NAD+ = Indole-3-acetaldehyde + NADH
SUBSTRATE   Indole-3-ethanol
            NAD+
PRODUCT     Indole-3-acetaldehyde
            NADH
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.190
            ExPASy - ENZYME nomenclature database: 1.1.1.190
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.190
            BRENDA, the Enzyme Database: 1.1.1.190
///
ENTRY       EC 1.1.1.191
NAME        Indole-3-acetaldehyde reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Indole-3-ethanol:NADP+ oxidoreductase
REACTION    Indole-3-ethanol + NADP+ = Indole-3-acetaldehyde + NADPH
SUBSTRATE   Indole-3-ethanol
            NADP+
PRODUCT     Indole-3-acetaldehyde
            NADPH
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.191
            ExPASy - ENZYME nomenclature database: 1.1.1.191
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.191
            BRENDA, the Enzyme Database: 1.1.1.191
///
ENTRY       EC 1.1.1.192
NAME        Long-chain-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Long-chain-alcohol:NAD+ oxidoreductase
REACTION    a Long-chain alcohol + 2 NAD+ + H2O = a Long-chain carboxylate +
            2 NADH
SUBSTRATE   Long-chain alcohol
            NAD+
            H2O
            Hexadecanol
PRODUCT     Long-chain carboxylate
            NADH
            Hexadecanoate
COMMENT     Hexadecanol is a good substrate.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.192
            ExPASy - ENZYME nomenclature database: 1.1.1.192
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.192
            BRENDA, the Enzyme Database: 1.1.1.192
///
ENTRY       EC 1.1.1.193
NAME        5-Amino-6-(5-phosphoribosylamino)uracil reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5-Amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase
REACTION    5-Amino-6-(5'-phosphoribitylamino)uracil + NADP+ =
            5-Amino-6-(5'-phosphoribosylamino)uracil + NADPH
SUBSTRATE   5-Amino-6-(5'-phosphoribitylamino)uracil
            NADP+
PRODUCT     5-Amino-6-(5'-phosphoribosylamino)uracil
            NADPH
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0414(ribD)
            ECE: Z0515(ribD)
            ECS: ECs0467
            YPE: YPO3183(ribD)
            HIN: HI0944(ribD)
            PMU: PM0749(ribD)
            XFA: XF0950
            VCH: VC2271
            PAE: PA4056(ribD)
            BUC: BU462(ribD2)
            NME: NMB1817
            NMA: NMA0644(ribD)
            HPY: HP1505(ribG)
            HPJ: jhp1398
            CJE: Cj1622(ribD)
            MLO: mlr8405
            SME: SMc01772(ribD)
            CCR: CC0885
            BSU: BG10518(ribG)
            BHA: BH1554(ribG)
            SAU: SA1589(ribD)
            SAV: SAV1755(ribD)
            LLA: L0163(ribG)
            SPN: SP0178
            SPR: spr0164(ribD)
            CAC: CAC0590(ribD)
            MTU: Rv1409(ribG) Rv2671(ribD)
            MTC: MT1453 MT2745
            MLE: ML0555(ribG) ML1340
            CTR: CT730
            CMU: TC0103
            CPN: CPn0871
            CPA: CP0998
            CPJ: ribD
            SYN: slr0066(ribD)
            DRA: DR0153
            AAE: aq_138(ribD1) aq_436(ribD2)
            TMA: TM1828
            MJA: MJ0671
            MTH: MTH235
            AFU: AF2007(ribG)
            HAL: VNG1256G(ribG)
            APE: APE1279
            SSO: SSO2097(ribD)
            STO: ST0285
            SCE: YBR153W(RIB7)
            SPO: SPBC21C3.10C(spbc21c3.10c)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.193
            ExPASy - ENZYME nomenclature database: 1.1.1.193
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.193
            BRENDA, the Enzyme Database: 1.1.1.193
///
ENTRY       EC 1.1.1.194
NAME        Coniferyl-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Coniferyl-alcohol:NADP+ oxidoreductase
REACTION    Coniferyl alcohol + NADP+ = Coniferyl aldehyde + NADPH
SUBSTRATE   Coniferyl alcohol
            NADP+
PRODUCT     Coniferyl aldehyde
            NADPH
COMMENT     Specific for coniferyl alcohol; does not act on cinnamyl alcohol,
            4-coumaryl alcohol or sinapyl alcohol.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.194
            ExPASy - ENZYME nomenclature database: 1.1.1.194
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.194
            BRENDA, the Enzyme Database: 1.1.1.194
///
ENTRY       EC 1.1.1.195
NAME        Cinnamyl-alcohol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cinnamyl-alcohol:NADP+ oxidoreductase
REACTION    Cinnamyl alcohol + NADP+ = Cinnamaldehyde + NADPH
SUBSTRATE   Cinnamyl alcohol
            NADP+
            Coniferyl alcohol
            Sinapyl alcohol
            4-Coumaryl alcohol
PRODUCT     Cinnamaldehyde
            NADPH
COMMENT     Acts on coniferyl alcohol, sinapyl alcohol, 4-coumaryl alcohol
            and cinnamyl alcohol (cf. EC 1.1.1.194)
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       ATH: At4g34230(F28A23.10)
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.195
            ExPASy - ENZYME nomenclature database: 1.1.1.195
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.195
            BRENDA, the Enzyme Database: 1.1.1.195
///
ENTRY       EC 1.1.1.196
NAME        15-Hydroxyprostaglandin-D dehydrogenase (NADP+)
            Prostaglandin-D 15-dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate:
            $NADP+ 15-oxidoreductase
REACTION    (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate +
            NADP+ =
            (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
SUBSTRATE   (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
            NADP+
            Prostaglandin D
PRODUCT     (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
            NADPH
COMMENT     Specific for prostaglandins D (cf. EC 1.1.1.141 and 1.1.1.197).
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.196
            ExPASy - ENZYME nomenclature database: 1.1.1.196
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.196
            BRENDA, the Enzyme Database: 1.1.1.196
///
ENTRY       EC 1.1.1.197
NAME        15-Hydroxyprostaglandin dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate:NADP+
            $ 15-oxidoreductase
REACTION    (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate + NADP+ =
            (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate + NADPH
SUBSTRATE   (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
            NADP+
            Prostaglandin E2
            Prostaglandin F2alpha
            Prostaglandin B1
PRODUCT     (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate
            NADPH
COMMENT     Acts on prostaglandins E2, F2alpha and B1, but not on
            prostaglandin D2 (cf. EC 1.1.1.141 and 1.1.1.196).  May be
            identical with EC 1.1.1.189.
GENES       HSA: 873(CBR1)
DISEASE     MIM: 114830  Carbonyl reductase 1
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.197
            ExPASy - ENZYME nomenclature database: 1.1.1.197
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.197
            BRENDA, the Enzyme Database: 1.1.1.197
///
ENTRY       EC 1.1.1.198
NAME        (+)-Borneol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+)-Borneol:NAD+ oxidoreductase
REACTION    (+)-Borneol + NAD+ = (+)-Camphor + NADH
SUBSTRATE   (+)-Borneol
            NAD+
PRODUCT     (+)-Camphor
            NADH
COMMENT     NADP+ can also act, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.198
            ExPASy - ENZYME nomenclature database: 1.1.1.198
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.198
            BRENDA, the Enzyme Database: 1.1.1.198
///
ENTRY       EC 1.1.1.199
NAME        (S)-Usnate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming)
REACTION    In the reverse direction, (S)-usnate is reduced by NADH with
            cleavage of the ether bond to form a 7-hydroxy group
SUBSTRATE   Reduced-(S)-usnate
            NAD+
PRODUCT     7-Hydroxy-(S)-usnate
            NADP+
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.199
            ExPASy - ENZYME nomenclature database: 1.1.1.199
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.199
            BRENDA, the Enzyme Database: 1.1.1.199
///
ENTRY       EC 1.1.1.200
NAME        Aldose-6-phosphate reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Aldose-6-phosphate:NADP+ 1-oxidoreductase
REACTION    D-Sorbitol 6-phosphate + NADP+ = D-Glucose 6-phosphate + NADPH
SUBSTRATE   D-Sorbitol 6-phosphate
            NADP+
PRODUCT     D-Glucose 6-phosphate
            NADPH
            D-Galactose 6-phosphate
COMMENT     In the reverse reaction, acts also on D-galactose 6-phosphate,
            and, more slowly, on D-mannose 6-phosphate and
            2-deoxy-D-glucose 6-phosphate.
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.200
            ExPASy - ENZYME nomenclature database: 1.1.1.200
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.200
            BRENDA, the Enzyme Database: 1.1.1.200
///
ENTRY       EC 1.1.1.201
NAME        7beta-Hydroxysteroid dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     7beta-Hydroxysteroid:NADP+ 7-oxidoreductase
REACTION    a 7beta-Hydroxysteroid + NADP+ = a 7-Oxosteroid + NADPH
SUBSTRATE   7beta-Hydroxysteroid
            NADP+
PRODUCT     7-Oxosteroid
            NADPH
COMMENT     Catalyses the oxidation of the 7beta-hydroxyl group of bile
            acids such as ursodeoxycholate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.201
            ExPASy - ENZYME nomenclature database: 1.1.1.201
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.201
            BRENDA, the Enzyme Database: 1.1.1.201
///
ENTRY       EC 1.1.1.202
NAME        1,3-Propanediol dehydrogenase
            3-Hydroxypropionaldehyde reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Propane-1,3-diol:NAD+ 1-oxidoreductase
REACTION    Propane-1,3-diol + NAD+ = 3-Hydroxypropanal + NADH
SUBSTRATE   Propane-1,3-diol
            NAD+
PRODUCT     3-Hydroxypropanal
            NADH
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       AAE: aq_1145(dhaT)
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.202
            ExPASy - ENZYME nomenclature database: 1.1.1.202
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.202
            BRENDA, the Enzyme Database: 1.1.1.202
///
ENTRY       EC 1.1.1.203
NAME        Uronate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Uronate:NAD+ 1-oxidoreductase
REACTION    D-Galacturonate + NAD+ + H2O = D-Galactarate + NADH
SUBSTRATE   D-Galacturonate
            NAD+
            H2O
            D-Glucuronate
PRODUCT     D-Galactarate
            NADH
            D-Glucatate
COMMENT     Also acts on D-glucuronate.  Formerly EC 1.2.1.35.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.203
            ExPASy - ENZYME nomenclature database: 1.1.1.203
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.203
            BRENDA, the Enzyme Database: 1.1.1.203
///
ENTRY       EC 1.1.1.204
NAME        Xanthine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Xanthine:NAD+ oxidoreductase
REACTION    Xanthine + NAD+ + H2O = Urate + NADH
SUBSTRATE   Xanthine
            NAD+
            H2O
PRODUCT     Urate
            NADH
COMMENT     Acts on a variety of purines and aldehydes. The animal enzyme can
            be interconverted to EC 1.1.3.22 (the oxidase form). That from
            liver exists in vivo mainly in the dehydrogenase form, but can
            be converted into EC 1.1.3.22 by storage at -20C, by treatment
            with proteolytic agents or organic solvents, or by thiol reagents
            such as Cu2+, N-ethylmaleimide or 4-hydroxy-mercuribenzoate.
            The effect of thiol reagents can be reversed by thiols such as
            1,4-dithio-erythritol. EC 1.1.1.204 can also be converted into
            EC 1.1.3.22 by EC 1.8.4.7 in the presence of oxidized glutathione.
            In other animal tissues the enzyme exists almost entirely as
            EC 1.1.3.22, but can be converted into the dehydrogenase form
            by 1,4-dithioerythritol. Formerly EC 1.2.1.37.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       PAE: PA1523(xdhB) PA1524(xdhA)
            MLO: mlr5134 mlr5135
            SME: SMb20846(xdhB2) SMb21011(xdhA2) SMb21286(xdhA1)
                 SMb21287(xdhB1)
            CCR: CC2618
            DRA: DRA0178
            CEL: F15E6.6 F55B11.1
            DME: CG7642
            MMU: 98973(Xdh)
            HSA: 7498(XDH)
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
STRUCTURES  PDB: 1FO4  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.204
            ExPASy - ENZYME nomenclature database: 1.1.1.204
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.204
            BRENDA, the Enzyme Database: 1.1.1.204
            SCOP (Structural Classification of Proteins): 1.1.1.204
///
ENTRY       EC 1.1.1.205
NAME        IMP dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     IMP:NAD+ oxidoreductase
REACTION    Inosine 5'-phosphate + NAD+ + H2O = Xanthosine 5'-phosphate + NADH
SUBSTRATE   Inosine 5'-phosphate
            NAD+
            H2O
PRODUCT     Xanthosine 5'-phosphate
            NADH
COMMENT     The enzyme acts on the hydroxyl group of the hydrated derivative
            of the substrate. Formerly EC 1.2.1.14.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2508(guaB)
            ECE: Z3772(guaB)
            ECS: ECs3370
            YPE: YPO2871(guaB)
            HIN: HI0221(guaB)
            PMU: PM0295(guaB)
            XFA: XF2430
            VCH: VC0767
            PAE: PA3770(guaB)
            NME: NMB1201
            NMA: NMA1372(guaB)
            HPY: HP0829(guaB)
            HPJ: jhp0768
            CJE: Cj1058c(guaB)
            MLO: mlr8350
            SME: SMb21441 SMc00815(guaB)
            CCR: CC1617
            BSU: BG10073(guaB) BG11600(yhcV)
            BHA: BH0020(guaB)
            SAU: SA0375(guaB)
            SAV: SAV0379(guaB)
            LLA: L21264(guaB)
            SPY: SPy2206(guaB)
            SPN: SP2228
            SPR: spr2033(imdH)
            CAC: CAC2701(guaB)
            MTU: Rv1843c(guaB1) Rv3410c(guaB3) Rv3411c(guaB2)
            MTC: MT1891 MT3518 MT3519
            MLE: ML0387(guaB2) ML0388(guaB3) ML2066(guaB1)
            CMU: TC0443
            CPN: CPn0172
            CPJ: guaB
            BBU: BBB17(guaB)
            SYN: slr0172(guaB) slr1722(guaB)
            DRA: DR1878
            AAE: aq_2023(guaB)
            TMA: TM1347
            MJA: MJ0188 MJ1616(guaB)
            MTH: MTH1282 MTH142
            AFU: AF0847(guaB-1) AF1259 AF2118(guaB-2)
            HAL: VNG0651G(imd1) VNG1001G(guaB)
            TAC: Ta0219
            TVO: TVG1445839
            PHO: PH0307
            PAB: PAB1250
            APE: APE1507
            SCE: YAR073W(FUN63) YHR216W(PUR5) YLR432W YML056C
            SPO: SPBC2F12.14C(spbc2f12.14c)
            ATH: At1g79470(T8K14.11)
            CEL: T22D1.3
            HSA: 3614(IMPDH1) 3615(IMPDH2)
DISEASE     MIM: 146691  Inosine-5'-monophosphate dehydrogenase, type II
MOTIF       PS: PS00487  [LIVM]-[RK]-[LIVM]-G-[LIVM]-G-x-G-S-[LIVM]-C-x-T
STRUCTURES  PDB: 1JR1  1EEP  1B3O  1AK5  1ZFJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.205
            ExPASy - ENZYME nomenclature database: 1.1.1.205
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.205
            BRENDA, the Enzyme Database: 1.1.1.205
            SCOP (Structural Classification of Proteins): 1.1.1.205
///
ENTRY       EC 1.1.1.206
NAME        Tropine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Tropine:NADP+ oxidoreductase
REACTION    Tropine + NADP+ = Tropinone + NADPH
SUBSTRATE   Tropine
            NADP+
PRODUCT     Tropinone
            NADPH
COMMENT     Also oxidizes other tropan-3alpha-ols, but not the corresponding
            beta-derivatives.
PATHWAY     PATH: MAP00960  Alkaloid biosynthesis II
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.206
            ExPASy - ENZYME nomenclature database: 1.1.1.206
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.206
            BRENDA, the Enzyme Database: 1.1.1.206
///
ENTRY       EC 1.1.1.207
NAME        (-)-Menthol dehydrogenase
            Monoterpenoid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-Menthol:NADP+ oxidoreductase
REACTION    (-)-Menthol + NADP+ = (-)-Menthone + NADPH
SUBSTRATE   (-)-Menthol
            NADP+
PRODUCT     (-)-Menthone
            NADPH
COMMENT     Not identical with EC 1.1.1.208.  Acts also on a number of other
            cyclohexanols and cyclohexenols.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.207
            ExPASy - ENZYME nomenclature database: 1.1.1.207
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.207
            BRENDA, the Enzyme Database: 1.1.1.207
///
ENTRY       EC 1.1.1.208
NAME        (+)-Neomenthol dehydrogenase
            Monoterpenoid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+)-Neomenthol:NADP+ oxidoreductase
REACTION    (+)-Neomenthol + NADP+ = (-)-Menthone + NADPH
SUBSTRATE   (+)-Neomenthol
            NADP+
PRODUCT     (-)-Menthone
            NADPH
COMMENT     Not identical with EC 1.1.1.207.  Acts also on a number of other
            cyclohexanols and cyclohexenols.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.208
            ExPASy - ENZYME nomenclature database: 1.1.1.208
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.208
            BRENDA, the Enzyme Database: 1.1.1.208
///
ENTRY       EC 1.1.1.209
NAME        3(or 17)alpha-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3(or 17)alpha-Hydroxysteroid:NAD(P)+ oxidoreductase
REACTION    Androsterone + NAD+ or NADP+ = 5alpha-Androstane-3,17-dione +
            NADH or NADPH
SUBSTRATE   Androsterone
            NAD+
            NADP+
PRODUCT     5alpha-Androstane-3,17-dione
            NADH
            NADPH
COMMENT     Acts on the 3alpha-hydroxyl group of androgens of the
            5alpha-androstane series; and also, more slowly, on the
            17alpha-hydroxyl group of both androgenic and estrogenic
            substrates (cf. EC 1.1.1.51).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.209
            ExPASy - ENZYME nomenclature database: 1.1.1.209
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.209
            BRENDA, the Enzyme Database: 1.1.1.209
///
ENTRY       EC 1.1.1.210
NAME        3beta(or 20alpha)-Hydroxysteroid dehydrogenase
            Progesterone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3beta(or 20alpha)-Hydroxysteroid:NADP+ oxidoreductase
REACTION    5alpha-Androstane-3beta,17beta-diol + NADP+ =
            17beta-Hydroxy-5alpha-androstan-3-one + NADPH
SUBSTRATE   5alpha-Androstane-3beta,17beta-diol
            NADP+
PRODUCT     17beta-Hydroxy-5alpha-androstan-3-one
            NADPH
COMMENT     Also acts on 20alpha-hydroxysteroids.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.210
            ExPASy - ENZYME nomenclature database: 1.1.1.210
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.210
            BRENDA, the Enzyme Database: 1.1.1.210
///
ENTRY       EC 1.1.1.211
NAME        Long-chain-3-hydroxyacyl-CoA dehydrogenase
            beta-Hydroxyacyl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
REACTION    (3S)-3-Hydroxyacyl-CoA + NAD+ = 3-Oxoacyl-CoA + NADH
SUBSTRATE   (3S)-3-Hydroxyacyl-CoA
            NAD+
PRODUCT     3-Oxoacyl-CoA
            NADH
COMMENT     Acts most rapidly on derivatives with chain-length 8 or 10
            (cf. EC 1.1.1.35).
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.211
            ExPASy - ENZYME nomenclature database: 1.1.1.211
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.211
            BRENDA, the Enzyme Database: 1.1.1.211
///
ENTRY       EC 1.1.1.212
NAME        3-Oxoacyl-[acyl-carrier protein] reductase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (3R)-3-Hydroxyacyl-[acyl-carrier-protein]:NAD+ oxidoreductase
REACTION    (3R)-3-Hydroxyacyl-[acyl-carrier protein] + NAD+ =
            3-Oxoacyl-[acyl-carrier protein] + NADH
SUBSTRATE   (3R)-3-Hydroxyacyl-[acyl-carrier protein]
            NAD+
PRODUCT     3-Oxoacyl-[acyl-carrier protein]
            NADH
COMMENT     Forms part of the fatty acid synthase system in plants.  Can be
            separated from EC 1.1.1.100.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.212
            ExPASy - ENZYME nomenclature database: 1.1.1.212
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.212
            BRENDA, the Enzyme Database: 1.1.1.212
///
ENTRY       EC 1.1.1.213
NAME        3alpha-Hydroxysteroid dehydrogenase (A-specific)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha-Hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)
REACTION    Androsterone + NAD+ or NADP+ = 5alpha-Androstane-3,17-dione +
            NADH or NADPH
SUBSTRATE   Androsterone
            NAD+
            NADP+
PRODUCT     5alpha-Androstane-3,17-dione
            NADH
            NADPH
COMMENT     Also acts on other 3alpha-hydroxysteroids.  A-specific with
            respect to NAD+ or NADP+ (cf. EC 1.1.1.50).
STRUCTURES  PDB: 1LWI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.213
            ExPASy - ENZYME nomenclature database: 1.1.1.213
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.213
            BRENDA, the Enzyme Database: 1.1.1.213
            SCOP (Structural Classification of Proteins): 1.1.1.213
///
ENTRY       EC 1.1.1.214
NAME        2-Dehydropantoyl-lactone reductase (B-specific)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-Pantoyl-lactone:NADP+ oxidoreductase (B-specific)
REACTION    (R)-Pantoyl lactone + NADP+ = 2-Dehydropantoyl lactone + NADPH
SUBSTRATE   (R)-Pantoyl lactone
            NADP+
PRODUCT     2-Dehydropantoyl lactone
            NADPH
COMMENT     The enzyme from E. coli is B-specific with respect to NADP+, in
            contrast with the yeast enzyme (EC 1.1.1.168).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.214
            ExPASy - ENZYME nomenclature database: 1.1.1.214
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.214
            BRENDA, the Enzyme Database: 1.1.1.214
///
ENTRY       EC 1.1.1.215
NAME        Gluconate 2-dehydrogenase
            2-Keto-D-gluconate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Gluconate:NADP+ oxidoreductase
REACTION    D-Gluconate + NADP+ = 2-Dehydro-D-gluconate + NADPH
SUBSTRATE   D-Gluconate
            NADP+
            L-Idonate
            D-Galactonate
            D-Xylonate
PRODUCT     2-Dehydro-D-gluconate
            NADPH
            2-Dehydro-L-idonate
            2-Dehydro-D-galactonate
            2-Dehydro-D-xylonate
COMMENT     Also acts on L-idonate, D-galactonate and D-xylonate.
GENES       ECO: b3553(yiaE)
            ECE: Z4978(yiaE)
            ECS: ECs4438
            BSU: BG12409(yvcT)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.215
            ExPASy - ENZYME nomenclature database: 1.1.1.215
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.215
            BRENDA, the Enzyme Database: 1.1.1.215
///
ENTRY       EC 1.1.1.216
NAME        Farnesol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-trans,6-trans-Farnesol:NADP+ 1-oxidoreductase
REACTION    2-trans,6-trans-Farnesol + NADP+ = 2-trans,6-trans-Farnesal +
            NADPH
SUBSTRATE   2-trans,6-trans-Farnesol
            NADP+
PRODUCT     2-trans,6-trans-Farnesal
            NADPH
COMMENT     Also acts, more slowly, on 2-cis,6-trans-farnesol, geraniol,
            citronerol and nerol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.216
            ExPASy - ENZYME nomenclature database: 1.1.1.216
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.216
            BRENDA, the Enzyme Database: 1.1.1.216
///
ENTRY       EC 1.1.1.217
NAME        Benzyl-2-methyl-hydroxybutyrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase
REACTION    Benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP+ =
            Benzyl 2-methyl-3-oxobutanoate + NADPH
SUBSTRATE   Benzyl (2R,3S)-2-methyl-3-hydroxybutanoate
            NADP+
            Benzyl (2S,3S)-2-methyl-3-hydroxybutanoate
PRODUCT     Benzyl 2-methyl-3-oxobutanoate
            NADPH
COMMENT     Also acts on benzyl (2S,3S)-2-methyl-3-hydroxybutanoate;
            otherwise highly specific.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.217
            ExPASy - ENZYME nomenclature database: 1.1.1.217
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.217
            BRENDA, the Enzyme Database: 1.1.1.217
///
ENTRY       EC 1.1.1.218
NAME        Morphine 6-dehydrogenase
            Naloxone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Morphine:NAD(P)+ 6-oxidoreductase
REACTION    Morphine + NAD+ or NADP+ = Morphinone + NADH or NADPH
SUBSTRATE   Morphine
            NAD+
            NADP+
PRODUCT     Morphinone
            NADH
            NADPH
EFFECTOR    2-Mercaptoethanol
COMMENT     Also acts on some other alkaloids, including codeine, normorphine
            and ethylmorphine, but only very slowly on 7,8-saturated
            derivatives such as dihydromorphine and dihydrocodeine.  In the
            reverse direction, also reduces naloxone to the 6alpha-hydroxy
            analogue.  Activated by 2-mercaptoethanol.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.218
            ExPASy - ENZYME nomenclature database: 1.1.1.218
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.218
            BRENDA, the Enzyme Database: 1.1.1.218
///
ENTRY       EC 1.1.1.219
NAME        Dihydrokaempferol 4-reductase
            Dihydroflavanol 4-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-3,4-Leucopelargonidin:NADP+ 4-oxidoreductase
REACTION    cis-3,4-Leucopelargonidin + NADP+ = (+)-Dihydrokaempferol + NADPH
SUBSTRATE   cis-3,4-Leucopelargonidin
            NADP+
            NAD+
PRODUCT     (+)-Dihydrokaempferol
            NADPH
            NADH
            (+)-Dihydroquercetin
            (+)-Dihydromyricetin
COMMENT     Also acts, in the reverse direction, on (+)-dihydroquercetin and
            (+)-dihydromyricetin; each dihydroflavonol is reduced to the
            corresponding cis-flavan-3,4-diol.  NAD+ can act instead of NADP+,
            more slowly.  Involved in the biosynthesis of anthocyanidins in
            plants.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       MTU: Rv0139
            MTC: MT0147
            SYN: slr1706(dfrA)
            ATH: At1g61720(T13M11.8)
            CEL: F13D11.4
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.219
            ExPASy - ENZYME nomenclature database: 1.1.1.219
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.219
            BRENDA, the Enzyme Database: 1.1.1.219
///
ENTRY       EC 1.1.1.220
NAME        6-Pyruvoyltetrahydropterin 2'-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-Lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase
REACTION    6-Lactoyl-5,6,7,8-tetrahydropterin + NADP+ =
            6-Pyruvoyl-tetrahydropterin + NADPH
SUBSTRATE   6-Lactoyl-5,6,7,8-tetrahydropterin
            NADP+
PRODUCT     6-Pyruvoyl-tetrahydropterin
            NADPH
COMMENT     Not identical with EC 1.1.1.153.
PATHWAY     PATH: MAP00790  Folate biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.220
            ExPASy - ENZYME nomenclature database: 1.1.1.220
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.220
            BRENDA, the Enzyme Database: 1.1.1.220
///
ENTRY       EC 1.1.1.221
NAME        Vomifoliol 4'-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Vomifoliol:NAD+ 4'-oxidoreductase
REACTION    (+/-)-6-Hydroxy-3-oxo-alpha-ionol + NAD+ =
            (+/-)-6-Hydroxy-3-oxo-alpha-ionone + NADH
SUBSTRATE   (+/-)-6-Hydroxy-3-oxo-alpha-ionol
            NAD+
            Vomifoliol
PRODUCT     (+/-)-6-Hydroxy-3-oxo-alpha-ionone
            NADH
            Dehydrovomifoliol
COMMENT     Oxidizes vomifoliol to dehydrovomifoliol; involved in the
            metabolism of abscisic acid in Corynebacterium sp.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.221
            ExPASy - ENZYME nomenclature database: 1.1.1.221
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.221
            BRENDA, the Enzyme Database: 1.1.1.221
///
ENTRY       EC 1.1.1.222
NAME        (R)-4-Hydroxyphenyllactate dehydrogenase
            (R)-Aromatic lactate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-3-(4-Hydroxyphenyl)lactate:NAD(P)+ 2-oxidoreductase
REACTION    (R)-3-(4-Hydroxyphenyl)lactate + NAD+ or NADP+ =
            3-(4-Hydroxyphenyl)pyruvate + NADH or NADPH
SUBSTRATE   (R)-3-(4-Hydroxyphenyl)lactate
            NAD+
            NADP+
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            NADH
            NADPH
COMMENT     Also acts, more slowly, on (R)-3-phenyllactate,
            (R)-3-(indole-3-yl)lactate and (R)-lactate.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.222
            ExPASy - ENZYME nomenclature database: 1.1.1.222
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.222
            BRENDA, the Enzyme Database: 1.1.1.222
///
ENTRY       EC 1.1.1.223
NAME        Isopiperitenol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-trans-Isopiperitenol:NAD+ oxidoreductase
REACTION    (-)-trans-Isopiperitenol + NAD+ = (-)-Isoperitenone + NADH
SUBSTRATE   (-)-trans-Isopiperitenol
            NAD+
            (+)-trans-Piperitenol
            (+)-trans-Pulegol
PRODUCT     (-)-Isoperitenone
            NADH
COMMENT     Acts on (-)-trans-isopiperitenol, (+)-trans-piperitenol and
            (+)-trans-pulegol.  Involved in the biosynthesis of menthol and
            related monoterpenes in peppermint (Mentha piperita) leaves.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.223
            ExPASy - ENZYME nomenclature database: 1.1.1.223
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.223
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.223
            BRENDA, the Enzyme Database: 1.1.1.223
///
ENTRY       EC 1.1.1.224
NAME        Mannose-6-phosphate 6-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Mannitol-1-phosphate:NADP+ 6-oxidoreductase
REACTION    D-Mannitol 1-phosphate + NADP+ = D-Mannose 6-phosphate + NADPH
SUBSTRATE   D-Mannitol 1-phosphate
            NADP+
PRODUCT     D-Mannose 6-phosphate
            NADPH
COMMENT     Involved in the biosynthesis of mannitol in celery (Apium
            graveolens) leaves.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.224
            ExPASy - ENZYME nomenclature database: 1.1.1.224
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.224
            BRENDA, the Enzyme Database: 1.1.1.224
///
ENTRY       EC 1.1.1.225
NAME        Chlordecone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Chlordecone-alcohol:NADP+ 2-oxidoreductase
REACTION    Chlordecone alcohol + NADP+ = Chlordecone + NADPH
SUBSTRATE   Chlordecone alcohol
            NADP+
PRODUCT     Chlordecone
            NADPH
COMMENT     Chlordecone, an organochlorine pesticide, is 1,1a,3,3a,4,5,5,5a,-
            5b,6-decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-
            -2-one.
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.225
            ExPASy - ENZYME nomenclature database: 1.1.1.225
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.225
            BRENDA, the Enzyme Database: 1.1.1.225
///
ENTRY       EC 1.1.1.226
NAME        4-Hydroxycyclohexanecarboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     trans-4-Hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase
REACTION    trans-4-Hydroxycyclohexanecarboxylate + NAD+ =
            4-Oxocyclohexanecarboxylate + NADH
SUBSTRATE   trans-4-Hydroxycyclohexanecarboxylate
            NAD+
PRODUCT     4-Oxocyclohexanecarboxylate
            NADH
COMMENT     The enzyme, from Corynebacterium cyclohexanicum, is highly
            specific for the trans-4-hydroxy derivative.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.226
            ExPASy - ENZYME nomenclature database: 1.1.1.226
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.226
            BRENDA, the Enzyme Database: 1.1.1.226
///
ENTRY       EC 1.1.1.227
NAME        (-)-Borneol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-Borneol:NAD+ oxidoreductase
REACTION    (-)-Borneol + NAD+ = (-)-Camphor + NADH
SUBSTRATE   (-)-Borneol
            NAD+
PRODUCT     (-)-Camphor
            NADH
COMMENT     NADP+ can also act, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.227
            ExPASy - ENZYME nomenclature database: 1.1.1.227
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.227
            BRENDA, the Enzyme Database: 1.1.1.227
///
ENTRY       EC 1.1.1.228
NAME        (+)-Sabinol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+)-cis-Sabinol:NAD+ oxidoreductase
REACTION    (+)-cis-Sabinol + NAD+ = (+)-Sabinone + NADH
SUBSTRATE   (+)-cis-Sabinol
            NAD+
PRODUCT     (+)-Sabinone
            NADH
COMMENT     NADP+ can also act, more slowly.  Involved in the biosynthesis of
            (+)-3-thujone and (-)-3-isothujone.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.228
            ExPASy - ENZYME nomenclature database: 1.1.1.228
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.228
            BRENDA, the Enzyme Database: 1.1.1.228
///
ENTRY       EC 1.1.1.229
NAME        Diethyl 2-methyl-3-oxosuccinate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+
            $ 3-oxidoreductase
REACTION    Diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP+ =
            Diethyl 2-methyl-3-oxosuccinate + NADPH
SUBSTRATE   Diethyl (2R,3R)-2-methyl-3-hydroxysuccinate
            NADP+
            Diethyl (2S,3R)-2-methyl-3-hydroxysuccinate
PRODUCT     Diethyl 2-methyl-3-oxosuccinate
            NADPH
COMMENT     Also acts on diethyl (2S,3R)-2-methyl-3-hydroxysuccinate, and on
            the corresponding dimethyl esters.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.229
            ExPASy - ENZYME nomenclature database: 1.1.1.229
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.229
            BRENDA, the Enzyme Database: 1.1.1.229
///
ENTRY       EC 1.1.1.230
NAME        3alpha-Hydroxyglycyrrhetinate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha-Hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase
REACTION    3alpha-Hydroxyglycyrrhetinate + NADP+ = 3-Oxoglycyrrhetinate +
            NADPH
SUBSTRATE   3alpha-Hydroxyglycyrrhetinate
            NADP+
PRODUCT     3-Oxoglycyrrhetinate
            NADPH
COMMENT     Highly specific to 3alpha-hydroxy derivatives of glycyrrhetinate
            and its analogues.  Not identical to EC 1.1.1.50.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.230
            ExPASy - ENZYME nomenclature database: 1.1.1.230
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.230
            BRENDA, the Enzyme Database: 1.1.1.230
///
ENTRY       EC 1.1.1.231
NAME        15-Hydroxyprostaglandin-I dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-
            $dienoate:NADP+ 15-oxidoreductase
REACTION    (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-
            $dienoate + NADP+ =
            (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-
            $dienoate + NADPH
SUBSTRATE   (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-
            $dienoate
            NADP+
            Prostaglandin I2
PRODUCT     (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-
            $dienoate
            NADPH
COMMENT     Specific for prostaglandin I2.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.231
            ExPASy - ENZYME nomenclature database: 1.1.1.231
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.231
            BRENDA, the Enzyme Database: 1.1.1.231
///
ENTRY       EC 1.1.1.232
NAME        15-Hydroxyicosatetraenoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+
            $ 15-oxidoreductase
REACTION    (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate +
            NAD+ or NADP+ = 15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate +
            NADH or NADPH
SUBSTRATE   (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
            NAD+
            NADP+
PRODUCT     15-Oxo-5,8,11-cis-13-trans-eicosatetraenoate
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.232
            ExPASy - ENZYME nomenclature database: 1.1.1.232
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.232
            BRENDA, the Enzyme Database: 1.1.1.232
///
ENTRY       EC 1.1.1.233
NAME        N-Acylmannosamine 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-Acyl-D-mannosamine:NAD+ 1-oxidoreductase
REACTION    N-Acyl-D-mannosamine + NAD+ = N-Acyl-D-mannosaminolactone + NADH
SUBSTRATE   N-Acyl-D-mannosamine
            NAD+
            N-Acetyl-D-mannosamine
            Glycolyl-D-mannosamine
PRODUCT     N-Acyl-D-mannosaminolactone
            NADH
            N-Acetyl-D-mannosaminolactone
            Glycolyl-D-mannosaminolactone
COMMENT     Acts on acetyl-D-mannosamine and glycolyl-D-mannosamine. Highly
            specific.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.233
            ExPASy - ENZYME nomenclature database: 1.1.1.233
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.233
            BRENDA, the Enzyme Database: 1.1.1.233
///
ENTRY       EC 1.1.1.234
NAME        Flavanone 4-reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (2S)-Flavan-4-ol:NADP+ 4-oxidoreductase
REACTION    (2S)-Flavan-4-ol + NADP+ = (2S)-Flavanone + NADPH
SUBSTRATE   (2S)-Flavan-4-ol
            NADP+
PRODUCT     (2S)-Flavanone
            NADPH
COMMENT     Involved in the biosynthesis of 3-deoxyanthocyanidins from
            flavanones such as naringenin or eriodictyol.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.234
            ExPASy - ENZYME nomenclature database: 1.1.1.234
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.234
            BRENDA, the Enzyme Database: 1.1.1.234
///
ENTRY       EC 1.1.1.235
NAME        8-Oxocoformycin reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Coformycin:NADP+ 8-oxidoreductase
REACTION    Coformycin + NADP+ = 8-Oxocoformycin + NADPH
SUBSTRATE   Coformycin
            NADP+
            Deoxycoformycin
PRODUCT     8-Oxocoformycin
            NADPH
            8-Oxodeoxycoformycin
COMMENT     B-specific with respect to NADPH.  Also reduces 8-oxodeoxy-
            coformycin to the nucleoside antibiotic deoxycoformycin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.235
            ExPASy - ENZYME nomenclature database: 1.1.1.235
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.235
            BRENDA, the Enzyme Database: 1.1.1.235
///
ENTRY       EC 1.1.1.236
NAME        Tropinone reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pseudotropine:NADP+ 3-oxidoreductase
REACTION    Pseudotropine + NADP+ = Tropinone + NADPH
SUBSTRATE   Pseudotropine
            NADP+
PRODUCT     Tropinone
            NADPH
PATHWAY     PATH: MAP00960  Alkaloid biosynthesis II
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1AE1  2AE1  2AE2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.236
            ExPASy - ENZYME nomenclature database: 1.1.1.236
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.236
            BRENDA, the Enzyme Database: 1.1.1.236
            SCOP (Structural Classification of Proteins): 1.1.1.236
///
ENTRY       EC 1.1.1.237
NAME        Hydroxyphenylpyruvate reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Hydroxyphenyllactate:NAD+ oxidoreductase
REACTION    3-(4-Hydroxyphenyl)lactate + NAD+ = 3-(4-Hydroxyphenyl)pyruvate +
            NADH
SUBSTRATE   3-(4-Hydroxyphenyl)lactate
            NAD+
            3-(3,4-Dihydroxyphenyl)lactate
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            NADH
            3-(3,4-Dihydroxyphenyl)pyruvate
COMMENT     Also acts on 3-(3,4-dihydroxyphenyl)lactate.  Involved with
            EC 2.3.1.140 in the biosynthesis of rosmarinic acid.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.237
            ExPASy - ENZYME nomenclature database: 1.1.1.237
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.237
            BRENDA, the Enzyme Database: 1.1.1.237
///
ENTRY       EC 1.1.1.238
NAME        12beta-Hydroxysteroid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     12beta-Hydroxysteroid:NADP+ 12-oxidoreductase
REACTION    3alpha,7alpha,12beta-Trihydroxy-5beta-cholanate + NADP+ =
            3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate + NADPH
SUBSTRATE   3alpha,7alpha,12beta-Trihydroxy-5beta-cholanate
            NADP+
PRODUCT     3alpha,7alpha-Dihydroxy-12-oxo-5beta-cholanate
            NADPH
COMMENT     Acts on a number of bile acids, both in their free and conjugated
            forms.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.238
            ExPASy - ENZYME nomenclature database: 1.1.1.238
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.238
            BRENDA, the Enzyme Database: 1.1.1.238
///
ENTRY       EC 1.1.1.239
NAME        3alpha(17beta)-Hydroxysteroid dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha(or 17beta)-Hydroxysteroid:NAD+ oxidoreductase
REACTION    Testosterone + NAD+ = Androst-4-ene-3,17-dione + NADH
SUBSTRATE   Testosterone
            NAD+
PRODUCT     Androst-4-ene-3,17-dione
            NADH
COMMENT     Also acts on other 17beta-hydroxysteroids, on the 3alpha-hydroxy
            group of pregnanes and bile acids, and on benzene dihydrodiol.
            Different from EC 1.1.1.50 or 1.1.1.213.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.239
            ExPASy - ENZYME nomenclature database: 1.1.1.239
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.239
            BRENDA, the Enzyme Database: 1.1.1.239
///
ENTRY       EC 1.1.1.240
NAME        N-Acetylhexosamine 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-Acetyl-D-hexosamine:NAD+ 1-oxidoreductase
REACTION    N-Acetyl-D-glucosamine + NAD+ = N-Acetyl-D-glucosaminate + NADH
SUBSTRATE   N-Acetyl-D-glucosamine
            NAD+
            N-Acetylgalactosamine
PRODUCT     N-Acetyl-D-glucosaminate
            NADH
            N-Acetylgalactosaminate
COMMENT     Also acts on N-acetylgalactosamine and, more slowly, on
            N-acetylmannosamine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.240
            ExPASy - ENZYME nomenclature database: 1.1.1.240
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.240
            BRENDA, the Enzyme Database: 1.1.1.240
///
ENTRY       EC 1.1.1.241
NAME        6-endo-Hydroxycineole dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-endo-Hydroxycineole:NAD+ 6-oxidoreductase
REACTION    6-endo-Hydroxycineole + NAD+ = 6-Oxocineole + NADH
SUBSTRATE   6-endo-Hydroxycineole
            NAD+
PRODUCT     6-Oxocineole
            NADH
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.241
            ExPASy - ENZYME nomenclature database: 1.1.1.241
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.241
            BRENDA, the Enzyme Database: 1.1.1.241
///
ENTRY       EC 1.1.1.242
NAME        Zeatin reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Dihydrozeatin:NADP+ oxidoreductase
REACTION    Dihydrozeatin + NADP+ = Zeatin + NADPH
SUBSTRATE   Dihydrozeatin
            NADP+
PRODUCT     Zeatin
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.242
            ExPASy - ENZYME nomenclature database: 1.1.1.242
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.242
            BRENDA, the Enzyme Database: 1.1.1.242
///
ENTRY       EC 1.1.1.243
NAME        Carveol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-trans-Carveol:NADP+ oxidoreductase
REACTION    (-)-trans-Carveol + NADP+ = (-)-Carvone + NADPH
SUBSTRATE   (-)-trans-Carveol
            NADP+
PRODUCT     (-)-Carvone
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.243
            ExPASy - ENZYME nomenclature database: 1.1.1.243
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.243
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.243
            BRENDA, the Enzyme Database: 1.1.1.243
///
ENTRY       EC 1.1.1.244
NAME        Methanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Methanol:NAD+ oxidoreductase
REACTION    Methanol + NAD+ = Formaldehyde + NADH
SUBSTRATE   Methanol
            NAD+
PRODUCT     Formaldehyde
            NADH
PATHWAY     PATH: MAP00680  Methane metabolism
GENES       YPE: YPO0327
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.244
            ExPASy - ENZYME nomenclature database: 1.1.1.244
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.244
            BRENDA, the Enzyme Database: 1.1.1.244
///
ENTRY       EC 1.1.1.245
NAME        Cyclohexanol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cyclohexanol:NAD+ oxidoreductase
REACTION    Cyclohexanol + NAD+ = Cyclohexanone + NADH
SUBSTRATE   Cyclohexanol
            NAD+
PRODUCT     Cyclohexanone
            NADH
COMMENT     Also oxidizes some other alicyclic alcohols and diols.
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.245
            ExPASy - ENZYME nomenclature database: 1.1.1.245
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.245
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.245
            BRENDA, the Enzyme Database: 1.1.1.245
///
ENTRY       EC 1.1.1.246
NAME        Pterocarpin synthase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Medicarpin:NADP+ 2'-oxidoreductase
REACTION    Medicarpin + NADP+ = Vestitone + NADPH
SUBSTRATE   Medicarpin
            NADP+
PRODUCT     Vestitone
            NADPH
COMMENT     Catalyses the final step in the biosynthesis of the pterocarpin
            phytoalexins medicarpin and maackiain.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.246
            ExPASy - ENZYME nomenclature database: 1.1.1.246
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.246
            BRENDA, the Enzyme Database: 1.1.1.246
///
ENTRY       EC 1.1.1.247
NAME        Codeinone reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    Codeinone + NADPH = Codeine + NADP+
SUBSTRATE   Codeinone
            NADPH
PRODUCT     Codeine
            NADP+
COMMENT     Stereospecifically catalyses the reversible reduction of codeinone
            to codeine, which is a direct precursor of morphine in the opium
            poppy plant, Papaver somniferum.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.247
            ExPASy - ENZYME nomenclature database: 1.1.1.247
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.247
///
ENTRY       EC 1.1.1.248
NAME        Salutaridine reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    Salutaridine + NADPH = Salutaridinol + NADP+
SUBSTRATE   Salutaridine
            NADPH
PRODUCT     Salutaridinol
            NADP+
COMMENT     Stereospecifically catalyses the reversible reduction of
            salutaridine to salutaridinol, which is a direct precursor of
            morphinan alkaloids in the poppy plant, Papaver somniferum.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.248
            ExPASy - ENZYME nomenclature database: 1.1.1.248
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.248
///
ENTRY       EC 1.1.1.249
NAME        Deleted entry
            [eIF-5A]-deoxyhypusine synthase
            Spermidine dehydrogenase
            (4-Aminobutyl)lysine synthase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
DISEASE     MIM: 600944  Deoxyhypusine synthase
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.249
            ExPASy - ENZYME nomenclature database: 1.1.1.249
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.249
///
ENTRY       EC 1.1.1.250
NAME        D-Arabinitol 2-dehydrogenase
            D-Arabinitol 2-dehydrogenase (ribulose-forming)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    D-Arabinitol + NAD+ =  D-Ribulose + NADH
SUBSTRATE   D-Arabinitol
            NAD+
PRODUCT     D-Ribulose
            NADH
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.250
            ExPASy - ENZYME nomenclature database: 1.1.1.250
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.250
///
ENTRY       EC 1.1.1.251
NAME        Galactitol-1-phosphate 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    Galactitol 1-phosphate + NAD+ = L-Tagatose 6-phosphate + NADH
SUBSTRATE   Galactitol 1-phosphate
            NAD+
PRODUCT     L-Tagatose 6-phosphate
            NADH
COFACTOR    Zinc
GENES       ECO: b2091(gatD)
            ECE: Z3254(gatD)
            ECS: ECs2894
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.251
            ExPASy - ENZYME nomenclature database: 1.1.1.251
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.251
///
ENTRY       EC 1.1.1.252
NAME        Tetrahydroxynaphthalene reductase
            T4HN reductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Scytalone:NADP+ delta5-oxidoreductase
REACTION    Scytalone + NADP+ = 1,3,6,8-Tetrahydroxynaphthalene + NADPH;
            Vermelone + NADP+ = 1,3,8-Trihydroxynaphthalene
SUBSTRATE   Scytalone
            NADP+
            Vermelone
PRODUCT     1,3,6,8-Tetrahydroxynaphthalene
            NADPH
            1,3,8-Trihydroxynaphthalene
COMMENT     Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also
            reduces 1,3,8-trihydroxynaphthalene to vermelone.
            Involved with EC 4.2.1.94 in the biosynthesis of melanin in
            pathogenic fungi.
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1G0O  1DOH  1G0N  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.252
            ExPASy - ENZYME nomenclature database: 1.1.1.252
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.252
///
ENTRY       EC 1.1.1.253
NAME        Pteridine reductase
            Pteridine reductase 1
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    5,6,7,8-Tetrahydrobiopterin + 2 NADP+ = Biopterin + 2 NADPH
SUBSTRATE   5,6,7,8-Tetrahydrobiopterin
            NADP+
PRODUCT     Biopterin
            NADPH
COMMENT     The enzyme from Leishmania (both amastigote and promastigote forms)
            catalyses the NADPH-dependent reduction of folate and a wide
            variety of unconjugated pterins, including biopterin, to their
            tetrahydro forms. It also catalyses the reduction of
            7,8-dihydropterins and 7,8-dihydrofolate to their tetrahydro forms.
            In contrast to dihydrofolate reductase (EC 1.5.1.3) and
            dihydropteridine reductase (EC 1.6.99.7), pteridine reductase will
            not catalyse the reduction of the quinonoid form of
            dihydrobiopterin.
            The enzyme is specific for NADPH; no activity has been detected
            with NADH. It also differs from EC 1.5.1.3 in being specific for
            the B side of NADPH.
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
STRUCTURES  PDB: 1E7W  1E92  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.253
            ExPASy - ENZYME nomenclature database: 1.1.1.253
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.253
///
ENTRY       EC 1.1.1.254
NAME        (S)-Carnitine 3-dehydrogenase
            D-Carnitine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    (S)-Carnitine + NAD+ = 3-Dehydrocarnitine + NADH
SUBSTRATE   (S)-Carnitine
            NAD+
PRODUCT     3-Dehydrocarnitine
            NADH
COMMENT     Specific for the (S)-enantiomer of carnitine, i.e. the enantiomer
            of the substrate of EC 1.1.1.108.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.254
            ExPASy - ENZYME nomenclature database: 1.1.1.254
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.254
///
ENTRY       EC 1.1.1.255
NAME        Mannitol dehydrogenase
            MTD
            NAD-dependent mannitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Mannitol:NAD 1-oxidoreductase
REACTION    D-Mannitol + NAD = D-Mannose + NADH
SUBSTRATE   D-Mannitol
            NAD
PRODUCT     D-Mannose
            NADH
COMMENT     The enzyme from Apium graveolens (celery) oxidises alditols with a
            minimum requirement of 2R chirality at the carbon adjacent to the
            primary carbon undergoing the oxidation. The enzyme is specific for
            NAD and does not use NADP.
GENES       ATH: At4g37980(F20D10.100) At4g37990(F20D10.110)
                 At4g39330(T22F8.230)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.255
            ExPASy - ENZYME nomenclature database: 1.1.1.255
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.255
///
ENTRY       EC 1.1.1.256
NAME        Fluoren-9-ol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Fluoren-9-ol:NAD(P) oxidoreductase
REACTION    Fluoren-9-ol + 2 NAD = Fluoren-9-one + 2 NADH;
            Fluoren-9-ol + 2 NADP = Fluoren-9-one + 2 NADPH
SUBSTRATE   Fluoren-9-ol
            NAD
            NADP
PRODUCT     Fluoren-9-one
            NADH
            NADPH
COMMENT     Involved in the pathway for fluorene metabolism in Arthrobacter sp.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.256
            ExPASy - ENZYME nomenclature database: 1.1.1.256
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.256
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.256
///
ENTRY       EC 1.1.1.257
NAME        4-(Hydroxymethyl)benzenesulfonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-(Hydroxymethyl)benzenesulfonate:NAD oxidoreductase
REACTION    4-(Hydroxymethyl)benzenesulfonate + NAD = 4-Formylbenzenesulfonate
            + NADH
SUBSTRATE   4-(Hydroxymethyl)benzenesulfonate
            NAD
PRODUCT     4-Formylbenzenesulfonate
            NADH
COMMENT     Involved in the toluene-4-sulfonate degradation pathway in
            Comamonas testosteroni.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.257
            ExPASy - ENZYME nomenclature database: 1.1.1.257
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.257
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.257
///
ENTRY       EC 1.1.1.258
NAME        6-Hydroxyhexanoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-Hydroxyhexanoate:NAD oxidoreductase
REACTION    6-Hydroxyhexanoate + NAD = 6-Oxohexanoate + NADH
SUBSTRATE   6-Hydroxyhexanoate
            NAD
PRODUCT     6-Oxohexanoate
            NADH
COMMENT     Involved in the cyclohexanol degradation pathway in Acinetobacter
            NCIB 9871.
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.258
            ExPASy - ENZYME nomenclature database: 1.1.1.258
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.258
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.258
///
ENTRY       EC 1.1.1.259
NAME        3-Hydroxypimeloyl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Hydroxypimeloyl-CoA:NAD oxidoreductase
REACTION    3-Hydroxypimeloyl-CoA + NAD = 3-Oxopimeloyl-CoA + NADH
SUBSTRATE   3-Hydroxypimeloyl-CoA
            NAD
PRODUCT     3-Oxopimeloyl-CoA
            NADH
COMMENT     Involved in the anaerobic pathway of benzoate degradation in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.1.259
            ExPASy - ENZYME nomenclature database: 1.1.1.259
            WIT (What Is There) Metabolic Reconstruction: 1.1.1.259
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.259
///
ENTRY       EC 1.1.2.1
NAME        Transferred to EC 1.1.99.5
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a cytochrome as acceptor
COMMENT     Transferred entry. Now EC 1.1.99.5 - Glycerol-3-phosphate
            dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.2.1
            ExPASy - ENZYME nomenclature database: 1.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.2.1
///
ENTRY       EC 1.1.2.2
NAME        Mannitol dehydrogenase (cytochrome)
            Polyol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a cytochrome as acceptor
SYSNAME     D-Mannitol:ferricytochrome-c 2-oxidoreductase
REACTION    D-Mannitol + Ferricytochrome c = D-Fructose + Ferrocytochrome c
SUBSTRATE   D-Mannitol
            Ferricytochrome c
            D-Sorbitol
PRODUCT     D-Fructose
            Ferrocytochrome c
COMMENT     Acts on polyols with a D-lyxo configuration, such as D-mannitol
            and D-sorbitol.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.2.2
            ExPASy - ENZYME nomenclature database: 1.1.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.2.2
            BRENDA, the Enzyme Database: 1.1.2.2
///
ENTRY       EC 1.1.2.3
NAME        L-Lactate dehydrogenase (cytochrome)
            Lactic acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a cytochrome as acceptor
SYSNAME     (S)-Lactate:ferricytochrome-c 2-oxidoreductase
REACTION    (S)-Lactate + 2 Ferricytochrome c = Pyruvate + 2 Ferrocytochrome c
SUBSTRATE   (S)-Lactate
            Ferricytochrome c
PRODUCT     Pyruvate
            Ferrocytochrome c
COFACTOR    FMN
COMMENT     Identical with cytochrome b2: a flavoprotein (FMN).
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b3605(lldD)
            ECE: Z5032(lldD)
            ECS: ECs4483
            YPE: YPO1569(lldD)
            HIN: HI1739.1(lldD)
            PMU: PM0288(lldD)
            VCH: VCA0984
            PAE: PA2382(lldA) PA4771(lldD)
            NME: NMB1377
            NMA: NMA1592(lldA)
            MLO: mll6909
            SME: SMb20850(lldD3) SMc01712(lldD2) SMc01740(lldD1)
            CCR: CC1151
            MTU: Rv0694(lldD1) Rv1872c(lldD2)
            MTC: MT0721 MT1921
            MLE: ML2046(lldD2)
            AFU: AF0807(lldD)
            SCE: YML054C(CYB2)
            CEL: F41E6.5
MOTIF       PS: PS00191  [FY]-[LIVMK]-x(2)-H-P-[GA]-G
            PS: PS00557  S-N-H-G-[AG]-R-Q
STRUCTURES  PDB: 1FCB  1LCO  1LDC  1LTD  1QCW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.2.3
            ExPASy - ENZYME nomenclature database: 1.1.2.3
            WIT (What Is There) Metabolic Reconstruction: 1.1.2.3
            BRENDA, the Enzyme Database: 1.1.2.3
            SCOP (Structural Classification of Proteins): 1.1.2.3
///
ENTRY       EC 1.1.2.4
NAME        D-Lactate dehydrogenase (cytochrome)
            Lactic acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a cytochrome as acceptor
SYSNAME     (R)-Lactate:ferricytochrome-c 2-oxidoreductase
REACTION    (R)-Lactate + 2 Ferricytochrome c = Pyruvate + 2 Ferrocytochrome c
SUBSTRATE   (R)-Lactate
            Ferricytochrome c
PRODUCT     Pyruvate
            Ferrocytochrome c
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       HPY: HP1222(dld)
            HPJ: jhp1143
            AFU: AF0394(dld)
            SCE: YDL174C(DLD1)
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.2.4
            ExPASy - ENZYME nomenclature database: 1.1.2.4
            WIT (What Is There) Metabolic Reconstruction: 1.1.2.4
            BRENDA, the Enzyme Database: 1.1.2.4
///
ENTRY       EC 1.1.2.5
NAME        D-Lactate dehydrogenase (cytochrome c-553)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a cytochrome as acceptor
SYSNAME     (R)-Lactate:ferricytochrome-c-553 2-oxidoreductase
REACTION    (R)-Lactate + 2 Ferricytochrome c-553 = Pyruvate +
            2 Ferrocytochrome c-553
SUBSTRATE   (R)-Lactate
            Ferricytochrome c-553
PRODUCT     Pyruvate
            Ferrocytochrome c-553
COMMENT     From Desulfovibrio vulgaris.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.2.5
            ExPASy - ENZYME nomenclature database: 1.1.2.5
            WIT (What Is There) Metabolic Reconstruction: 1.1.2.5
            BRENDA, the Enzyme Database: 1.1.2.5
///
ENTRY       EC 1.1.3.1
NAME        Deleted entry
            Glycolate oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
COMMENT     Deleted entry. Now included with EC 1.1.3.15.
STRUCTURES  PDB: 1GOX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.1
            ExPASy - ENZYME nomenclature database: 1.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.1
            SCOP (Structural Classification of Proteins): 1.1.3.1
///
ENTRY       EC 1.1.3.2
NAME        Transferred to EC 1.13.12.4
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
COMMENT     Transferred entry. Now EC 1.13.12.4 - Lactate 2-monooxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.2
            ExPASy - ENZYME nomenclature database: 1.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.2
///
ENTRY       EC 1.1.3.3
NAME        Malate oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Malate:oxygen oxidoreductase
REACTION    (S)-Malate + O2 = Oxaloacetate + H2O2
SUBSTRATE   (S)-Malate
            O2
PRODUCT     Oxaloacetate
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.3
            ExPASy - ENZYME nomenclature database: 1.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.3
            BRENDA, the Enzyme Database: 1.1.3.3
///
ENTRY       EC 1.1.3.4
NAME        Glucose oxidase
            Glucose oxyhydrase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     beta-D-Glucose:oxygen 1-oxidoreductase
REACTION    beta-D-Glucose + O2 = D-Glucono-1,5-lactone + H2O2
SUBSTRATE   beta-D-Glucose
            O2
PRODUCT     D-Glucono-1,5-lactone
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
MOTIF       PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
STRUCTURES  PDB: 1GPE  1GAL  1CF3  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.4
            ExPASy - ENZYME nomenclature database: 1.1.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.4
            BRENDA, the Enzyme Database: 1.1.3.4
            SCOP (Structural Classification of Proteins): 1.1.3.4
///
ENTRY       EC 1.1.3.5
NAME        Hexose oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     D-Hexose:oxygen 1-oxidoreductase
REACTION    beta-D-Glucose + O2 = D-Glucono-1,5-lactone + H2O2
SUBSTRATE   beta-D-Glucose
            O2
            D-Galactose
            D-Mannose
            Maltose
            Lactose
            Cellobiose
PRODUCT     D-Glucono-1,5-lactone
            H2O2
COFACTOR    Copper
COMMENT     A copper glycoprotein.  Also oxidizes D-galactose, D-mannose,
            maltose, lactose and cellobiose.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.5
            ExPASy - ENZYME nomenclature database: 1.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.5
            BRENDA, the Enzyme Database: 1.1.3.5
///
ENTRY       EC 1.1.3.6
NAME        Cholesterol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Cholesterol:oxygen oxidoreductase
REACTION    Cholesterol + O2 = Cholest-4-en-3-one + H2O2
SUBSTRATE   Cholesterol
            O2
PRODUCT     Cholest-4-en-3-one
            H2O2
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
MOTIF       PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
STRUCTURES  PDB: 1CC2  1I19  1CBO  1B8S  1B4V  3COX  1COY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.6
            ExPASy - ENZYME nomenclature database: 1.1.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.6
            BRENDA, the Enzyme Database: 1.1.3.6
            SCOP (Structural Classification of Proteins): 1.1.3.6
///
ENTRY       EC 1.1.3.7
NAME        Aryl-alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Aryl-alcohol:oxygen oxidoreductase
REACTION    an Aromatic primary alcohol + O2 = an Aromatic aldehyde + H2O2
SUBSTRATE   Aromatic primary alcohol
            O2
            (2-Naphthyl)methanol
            3-Methoxybenzyl alcohol
PRODUCT     Aromatic aldehyde
            H2O2
COMMENT     Oxidizes many primary alcohols containing an aromatic ring; best
            substrates are (2-naphthyl)methanol and 3-methoxybenzyl alcohol.
STRUCTURES  PDB: 1QLU  1QJN  1E8H  1E8F  1QLT  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.7
            ExPASy - ENZYME nomenclature database: 1.1.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.7
            BRENDA, the Enzyme Database: 1.1.3.7
            SCOP (Structural Classification of Proteins): 1.1.3.7
///
ENTRY       EC 1.1.3.8
NAME        L-Gulonolactone oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     L-Gulono-1,4-lactone:oxygen 2-oxidoreductase
REACTION    L-Gulono-1,4-lactone + O2 = L-xylo-Hexulonolactone + H2O2
SUBSTRATE   L-Gulono-1,4-lactone
            O2
PRODUCT     L-xylo-Hexulonolactone
            H2O2
            L-Ascorbate
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). The product spontaneously isomerizes to
            L-ascorbate.
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
MOTIF       PS: PS00862  P-x(10)-[DE]-[LIVM]-x(3)-[LIVM]-x(9)-[LIVM]-x(3)-[GSA]-
                         [GST]-G-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.8
            ExPASy - ENZYME nomenclature database: 1.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.8
            BRENDA, the Enzyme Database: 1.1.3.8
///
ENTRY       EC 1.1.3.9
NAME        Galactose oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     D-Galactose:oxygen 6-oxidoreductase
REACTION    D-Galactose + O2 = D-Galacto-hexodialdose + H2O2
SUBSTRATE   D-Galactose
            O2
PRODUCT     D-Galacto-hexodialdose
            H2O2
COFACTOR    Copper
COMMENT     A copper protein
PATHWAY     PATH: MAP00052  Galactose metabolism
STRUCTURES  PDB: 1GOH  1GOF  1GOG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.9
            ExPASy - ENZYME nomenclature database: 1.1.3.9
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.9
            BRENDA, the Enzyme Database: 1.1.3.9
            SCOP (Structural Classification of Proteins): 1.1.3.9
///
ENTRY       EC 1.1.3.10
NAME        Pyranose oxidase
            Glucose 2-oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Pyranose:oxygen 2-oxidoreductase
REACTION    D-Glucose + O2 = 2-Dehydro-D-glucose + H2O2
SUBSTRATE   D-Glucose
            O2
            D-Xylose
            L-Sorbose
            D-Glucono-1,5-lactone
PRODUCT     2-Dehydro-D-glucose
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also oxidizes D-xylose, L-sorbose and
            D-glucono-1,5-lactone, which have the same ring conformation and
            configuration at C-2, C-3 and C-4.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.10
            ExPASy - ENZYME nomenclature database: 1.1.3.10
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.10
            BRENDA, the Enzyme Database: 1.1.3.10
///
ENTRY       EC 1.1.3.11
NAME        L-Sorbose oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     L-Sorbose:oxygen 5-oxidoreductase
REACTION    L-Sorbose + O2 = 5-Dehydro-D-fructose + H2O2
SUBSTRATE   L-Sorbose
            O2
            D-Glucose
            D-Galactose
            D-Xylose
            2,6-Dichloroindophenol
PRODUCT     5-Dehydro-D-fructose
            H2O2
COMMENT     Also acts on D-glucose, D-galactose and D-xylose, but not on
            D-fructose.  2,6-Dichloroindophenol can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.11
            ExPASy - ENZYME nomenclature database: 1.1.3.11
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.11
            BRENDA, the Enzyme Database: 1.1.3.11
///
ENTRY       EC 1.1.3.12
NAME        Pyridoxine 4-oxidase
            Pyridoxin 4-oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Pyridoxine:oxygen 4-oxidoreductase
REACTION    Pyridoxine + O2 = Pyridoxal + H2O2
SUBSTRATE   Pyridoxine
            O2
            2,6-Dichloroindophenol
PRODUCT     Pyridoxal
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein.  Can also use 2,6-dichloroindophenol as an
            an acceptor.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.12
            ExPASy - ENZYME nomenclature database: 1.1.3.12
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.12
            BRENDA, the Enzyme Database: 1.1.3.12
///
ENTRY       EC 1.1.3.13
NAME        Alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Alcohol:oxygen oxidereductase
REACTION    Primary alcohol + O2 = Aldehyde + H2O2
SUBSTRATE   Lower primary alcohol
            Unsaturated alcohol
            O2
PRODUCT     Aldehyde
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD); acts on lower primary alcohols and
            unsaturated alcohols but branched-chain and secondary alcohols
            are not attacked.
PATHWAY     PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
STRUCTURES  PDB: 1AHZ  1AHU  1VAO  2VAO  1AHV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.13
            ExPASy - ENZYME nomenclature database: 1.1.3.13
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.13
            BRENDA, the Enzyme Database: 1.1.3.13
            SCOP (Structural Classification of Proteins): 1.1.3.13
///
ENTRY       EC 1.1.3.14
NAME        Catechol oxidase (dimerizing)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Catechol:oxygen oxidoreductase (dimerizing)
REACTION    4 Catechol + 3 O2 = 2 Dibenzo[1,4]dioxin-2,3-dione + 6 H2O
SUBSTRATE   Catechol
            O2
PRODUCT     Dibenzo[1,4]dioxin-2,3-dione
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.14
            ExPASy - ENZYME nomenclature database: 1.1.3.14
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.14
            BRENDA, the Enzyme Database: 1.1.3.14
///
ENTRY       EC 1.1.3.15
NAME        (S)-2-Hydroxy-acid oxidase
            Glycolate oxidase
            Hydroxy-acid oxidase A
            Hydroxy-acid oxidase B
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     (S)-2-Hydroxy-acid:oxygen 2-oxidoreductase
REACTION    (S)-2-Hydroxy acid + O2 = 2-Oxo acid + H2O2
SUBSTRATE   (S)-2-Hydroxy acid
            O2
            Aliphatic hydroxy acid
            Aromatic hydroxy acid
PRODUCT     2-Oxo acid
            H2O2
COFACTOR    FMN
COMMENT     A flavoprotein (FMN). Exists as two major ioenzymes; the A form
            preferentially oxidizes short-chain aliphatic hydroxy acids, and
            was previously listed as EC 1.1.3.1, glycolate oxidase; the B
            form preferentially oxidizes long-chain and aromatic hydroxy
            acids. The rat isoenzyme B also acts as L-amino-acid oxidase
            (EC 1.4.3.2).
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b2979(glcD)
            PAE: PA5355(glcD)
            HPY: HP0509(glcD)
            HPJ: jhp0459
            CJE: Cj1213c(glcD)
            MLO: mll4732 mlr6916
            BSU: BG12320(ysfC)
            BHA: BH2134 BH2730
            CAC: CAC2542
            MTU: Rv1257c
            MTC: MT1296
            MLE: ML1103
            SYN: sll0404(glcD)
            DRA: DR1031 DR1731
            AFU: AF0808(glcD)
            TAC: Ta0542
            TVO: TVG0585220
            APE: APE0487
            SSO: SSO3163(glcD)
            STO: ST0649
            HSA: 51179(HAO2) 51273(HAO3) 54363(HAO1)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00557  S-N-H-G-[AG]-R-Q
STRUCTURES  PDB: 1GYL  1AL8  1AL7  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.15
            ExPASy - ENZYME nomenclature database: 1.1.3.15
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.15
            BRENDA, the Enzyme Database: 1.1.3.15
            SCOP (Structural Classification of Proteins): 1.1.3.15
///
ENTRY       EC 1.1.3.16
NAME        Ecdysone oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Ecdysone:oxygen 3-oxidoreductase
REACTION    Ecdysone + O2 = 3-Dehydroecdysone + H2O2
SUBSTRATE   Ecdysone
            O2
            2,6-Dichloroindophenol
PRODUCT     3-Dehydroecdysone
            H2O2
COMMENT     2,6-Dichloroindophenol can act as an acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.16
            ExPASy - ENZYME nomenclature database: 1.1.3.16
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.16
            BRENDA, the Enzyme Database: 1.1.3.16
///
ENTRY       EC 1.1.3.17
NAME        Choline oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Choline:oxygen 1-oxidoreductase
REACTION    Choline + O2 = Betaine aldehyde + H2O2
SUBSTRATE   Choline
            Betaine aldehyde
            O2
PRODUCT     Betaine aldehyde
            H2O2
            Betaine
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also oxidizes betaine aldehyde to betaine.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.17
            ExPASy - ENZYME nomenclature database: 1.1.3.17
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.17
            BRENDA, the Enzyme Database: 1.1.3.17
///
ENTRY       EC 1.1.3.18
NAME        Secondary-alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Secondary-alcohol:oxygen oxidoreductase
REACTION    a Secondary alcohol + O2 = a Ketone + H2O2
SUBSTRATE   Secondary alcohol
            O2
PRODUCT     Ketone
            H2O2
COMMENT     Acts on secondary alcohols with five or more carbons, and
            polyvinyl alcohols with molecular mass over 300 Da.  The
            Pseudomonas enzyme contains one atom of non-heme iron per
            molecule.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.18
            ExPASy - ENZYME nomenclature database: 1.1.3.18
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.18
            BRENDA, the Enzyme Database: 1.1.3.18
///
ENTRY       EC 1.1.3.19
NAME        4-Hydroxymandelate oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase
REACTION    (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate + O2 =
            4-Hydroxybenzaldehyde + CO2 + H2O2
SUBSTRATE   (S)-2-Hydroxy-2-(4-hydroxyphenyl)acetate
            O2
PRODUCT     4-Hydroxybenzaldehyde
            CO2
            H2O2
COFACTOR    FAD
            Manganese
COMMENT     A flavoprotein (FAD); requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.19
            ExPASy - ENZYME nomenclature database: 1.1.3.19
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.19
            BRENDA, the Enzyme Database: 1.1.3.19
///
ENTRY       EC 1.1.3.20
NAME        Long-chain-alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Long-chain-alcohol:oxygen oxidoreductase
REACTION    2 Long-chain alcohol + O2 = 2 Long-chain aldehyde + 2 H2O
SUBSTRATE   Long-chain alcohol
            O2
            Dodecylalcohol
PRODUCT     Long-chain aldehyde
            H2O
            Dodecylaldehyde
COMMENT     Oxidizes long-chain fatty alcohols; best substrate is dodecyl
            alcohol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.20
            ExPASy - ENZYME nomenclature database: 1.1.3.20
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.20
            BRENDA, the Enzyme Database: 1.1.3.20
///
ENTRY       EC 1.1.3.21
NAME        Glycerol-3-phosphate oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     sn-Glycerol-3-phosphate:oxygen 2-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + O2 = Glycerone phosphate + H2O2
SUBSTRATE   sn-Glycerol 3-phosphate
            O2
PRODUCT     Glycerone phosphate
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.21
            ExPASy - ENZYME nomenclature database: 1.1.3.21
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.21
            BRENDA, the Enzyme Database: 1.1.3.21
///
ENTRY       EC 1.1.3.22
NAME        Xanthine oxidase
            Hypoxanthine oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Xanthine:oxygen oxidoreductase
REACTION    Xanthine + H2O + O2 = Urate + H2O2
SUBSTRATE   Xanthine
            Hypoxanthine
            Purine
            Pterin
            Aldehyde
            H2O
            O2
PRODUCT     Urate
            H2O2
            O2-
INHIBITOR   Disulfiram
COFACTOR    FAD
            Iron
            Molybdenum
COMMENT     An iron-molybdenum flavoprotein (FAD). Also oxidizes
            hypoxanthine, some other purines and pterins, and aldehydes
            (i.e. possesses the activity of EC 1.2.3.1);
            probably acts on the hydrated derivatives of these substrates.
            Under some conditions the product is mainly superoxide rather
            than peroxide: R-H + H2O = ROH + 2 O2-.
            The enzyme from animal tissues can be interconverted to EC
            1.1.1.204. That from liver exists in vivo mainly as the
            dehydrogenase form, but can be converted into the oxidase form
            by storage at -20C, by treatment with proteolytic enzymes or
            with organic solvents, or by thiol reagents such as Cu2+,
            N-ethylmaleimide or 4-mercuribenzoate. The effect of
            thiol reagents can be reversed by thiols such as 1,4-
            dithioerythritol. EC 1.1.1.204 can also be converted into EC
            1.1.3.22 by EC 1.8.4.7 in the presence of oxidized glutathione.
            The Micrococcus enzyme can use ferredoxin as acceptor.
            Formerly EC 1.2.3.2.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       CEL: F15E6.6
            MMU: 98973(Xdh)
            HSA: 7498(XDH)
DISEASE     MIM: 278300  Xanthine dehydrogenase (xanthine oxidase)
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
STRUCTURES  PDB: 1FIQ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.22
            ExPASy - ENZYME nomenclature database: 1.1.3.22
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.22
            BRENDA, the Enzyme Database: 1.1.3.22
            SCOP (Structural Classification of Proteins): 1.1.3.22
///
ENTRY       EC 1.1.3.23
NAME        Thiamin oxidase
            Thiamin dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Thiamin:oxygen 5-oxidoreductase
REACTION    Thiamine + 2 O2 = Thiamine acetic acid + 2 H2O2
SUBSTRATE   Thiamine
            O2
PRODUCT     Thiamine acetic acid
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  The product differs from thiamine in
            replacement of -CH2.CH2.OH by -CH2.COOH; the two-step oxidation
            proceeds without the release of the intermediate aldehyde from
            the enzyme.
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.23
            ExPASy - ENZYME nomenclature database: 1.1.3.23
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.23
            BRENDA, the Enzyme Database: 1.1.3.23
///
ENTRY       EC 1.1.3.24
NAME        L-Galactonolactone oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     L-Galactono-1,4-lactone:oxygen 3-oxidoreductase
REACTION    L-Galactono-1,4-lactone + O2 = L-Ascorbate + H2O2
SUBSTRATE   L-Galactono-1,4-lactone
            O2
PRODUCT     L-Ascorbate
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein.  Acts on the 1,4-lactone of L-galactonic,
            D-altronic, L-fuconic, D-arabinic and D-threonic acids; not
            identical with EC 1.1.3.8. (cf. EC 1.3.2.3).
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.24
            ExPASy - ENZYME nomenclature database: 1.1.3.24
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.24
            BRENDA, the Enzyme Database: 1.1.3.24
///
ENTRY       EC 1.1.3.25
NAME        Cellobiose oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Cellobiose:oxygen 1-oxidoreductase
REACTION    Cellobiose + O2 = Cellobiose-1,5-lactone + H2O2
SUBSTRATE   Cellobiose
            O2
            Cellodextrin
            Lactose
PRODUCT     Cellobiose-1,5-lactone
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein.  Also oxidizes cellodextrins, lactose, and,
            more slowly, 4-beta-D-glucosyl-D-mannose.
STRUCTURES  PDB: 1D7D  1D7C  1D7B  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.25
            ExPASy - ENZYME nomenclature database: 1.1.3.25
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.25
            BRENDA, the Enzyme Database: 1.1.3.25
            SCOP (Structural Classification of Proteins): 1.1.3.25
///
ENTRY       EC 1.1.3.26
NAME        Columbamine oxidase
            Berberine synthase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Columbamine:oxygen oxidoreductase (cyclizing)
REACTION    2 Columbamine + O2 = 2 Berberine + 2 H2O
SUBSTRATE   Columbamine
            O2
PRODUCT     Berberine
            H2O
COFACTOR    Iron
COMMENT     Oxidation of the O-methoxyphenol structure forms the
            methylenedioxy group of berberine.  An iron protein.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.26
            ExPASy - ENZYME nomenclature database: 1.1.3.26
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.26
            BRENDA, the Enzyme Database: 1.1.3.26
///
ENTRY       EC 1.1.3.27
NAME        Hydroxyphytanate oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     L-2-Hydroxyphytanate:oxygen 2-oxidoreductase
REACTION    L-2-Hydroxyphytanate + O2 = 2-Oxophytanate + H2O2
SUBSTRATE   L-2-Hydroxyphytanate
            O2
PRODUCT     2-Oxophytanate
            H2O2
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.27
            ExPASy - ENZYME nomenclature database: 1.1.3.27
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.27
            BRENDA, the Enzyme Database: 1.1.3.27
///
ENTRY       EC 1.1.3.28
NAME        Nucleoside oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Nucleoside:oxygen 5'-oxidoreductase
REACTION    2 Inosine + O2 = 2 5'-Oxoinosine + 2 H2O
SUBSTRATE   Inosine
            O2
PRODUCT     5'-Oxoinosine
            H2O
            Inosine-5'-carboxylate
COMMENT     Also oxidizes 5'-oxoinosine to inosine-5'-carboxylate.  Other
            purine nucleosides and, more slowly, pyrimidine nucleosides can
            also act as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.28
            ExPASy - ENZYME nomenclature database: 1.1.3.28
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.28
            BRENDA, the Enzyme Database: 1.1.3.28
///
ENTRY       EC 1.1.3.29
NAME        N-Acylhexosamine oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     N-Acyl-D-hexosamine:oxygen 1-oxidoreductase
REACTION    N-Acetyl-D-glucosamine + O2 = N-Acetyl-D-glucosaminate + H2O2
SUBSTRATE   N-Acetyl-D-glucosamine
            O2
            N-Glycolyl-D-glucosamine
            N-Acetyl-D-galactosamine
            N-Acetyl-D-mannosamine
PRODUCT     N-Acetyl-D-glucosaminate
            H2O2
COMMENT     Also acts on N-glycolylglucosamine, N-acetylgalactosamine and,
            more slowly, on N-acetylmannosamine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.29
            ExPASy - ENZYME nomenclature database: 1.1.3.29
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.29
            BRENDA, the Enzyme Database: 1.1.3.29
///
ENTRY       EC 1.1.3.30
NAME        Polyvinyl-alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Polyvinyl-alcohol:oxygen oxidoreductase
REACTION    Polyvinyl alcohol + O2 = Oxidized polyvinyl alcohol + H2O2
SUBSTRATE   Polyvinyl alcohol
            O2
PRODUCT     Oxidized polyvinyl alcohol
            H2O2
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.30
            ExPASy - ENZYME nomenclature database: 1.1.3.30
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.30
            BRENDA, the Enzyme Database: 1.1.3.30
///
ENTRY       EC 1.1.3.31
NAME        Methanol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
SYSNAME     Methanol:oxygen oxidoreductase
REACTION    Methanol + O2 = Formaldehyde + H2O2
SUBSTRATE   Methanol
            O2
PRODUCT     Formaldehyde
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Acts on some other aliphatic alcohols,
            more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.31
            ExPASy - ENZYME nomenclature database: 1.1.3.31
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.31
            BRENDA, the Enzyme Database: 1.1.3.31
///
ENTRY       EC 1.1.3.32
NAME        (S)-Stylopine synthase
            (S)-Cheilanthifoline oxidase (methylene-bridge forming)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (S)-Cheilanthifoline + NADPH + O2 =
            (S)-Stylopine + NADP+ + 2 H2O
SUBSTRATE   (S)-Cheilanthifoline
            NADPH
            O2
PRODUCT     (S)-Stylopine
            NADP+
            H2O
COMMENT     Catalyses an oxidative reaction that does not incorporate oxygen
            into the product. Forms the second methylenedioxy bridge of the
            Protoberberine alkaloid Stylopine from oxidative ring closure of
            adjacent phenolic and methoxy groups of Cheilanthifoline.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.32
            ExPASy - ENZYME nomenclature database: 1.1.3.32
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.32
///
ENTRY       EC 1.1.3.33
NAME        (S)-Cheilanthifoline synthase
            (S)-Scoulerine oxidase (methylenedioxy-bridge forming)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (S)-Scoulerine + NADPH + O2 =
            (S)-Cheilanthifoline + NADP+ + 2 H2O
SUBSTRATE   (S)-Scoulerine
            NADPH
            O2
PRODUCT     (S)-Cheilanthifoline
            NADP+
            H2O
COMMENT     Catalyses an oxidative reaction that does not incorporate oxygen
            into the product. Forms the methylenedioxy bridge of the
            Protoberberine alkaloid Cheilanthifoline from oxidative ring closure
            of adjacent phenolic and methoxy groups of Scoulerine.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.33
            ExPASy - ENZYME nomenclature database: 1.1.3.33
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.33
///
ENTRY       EC 1.1.3.34
NAME        Berbamunine synthase
            (S)-N-Methylcoclaurine oxidase (C-O phenol-coupling)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (S)-N-Methylcoclaurine + (R)-N-Methylcoclaurine + NADPH + O2 =
            Berbamunine + NADP+ + 2 H2O
SUBSTRATE   (S)-N-Methylcoclaurine
            (R)-N-Methylcoclaurine
            NADPH
            O2
PRODUCT     Berbamunine
            NADP+
            H2O
COMMENT     Forms the bisbenzylquinone alkaloid Berbamunine by phenol oxidation
            of N-Methylcoclaurine without the incorporation of oxygen into the
            product.
            Reaction of 2 molecules of (R)-N-Methylcoclaurine gives the dimer
            Guattagaumerine.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.34
            ExPASy - ENZYME nomenclature database: 1.1.3.34
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.34
///
ENTRY       EC 1.1.3.35
NAME        Salutaridine synthase
            (R)-Reticuline oxidase (C-O phenol-coupling)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (R)-Reticuline + NADPH + O2 = Salutaridine + NADP+ + 2 H2O
SUBSTRATE   (R)-Reticuline
            NADPH
            O2
PRODUCT     Salutaridine
            NADP+
            H2O
COMMENT     Forms the Merphinan alkaloid Salutaridine by intramolecular phenol
            oxidation of Reticuline without the incorpotation of oxygen into the
            product.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.35
            ExPASy - ENZYME nomenclature database: 1.1.3.35
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.35
///
ENTRY       EC 1.1.3.36
NAME        (S)-Canadine synthase
            (S)-Tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming)
            (S)-Tetrahydroberberine synthase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    (S)-Tetrahydrocolumbamine + NADPH + O2 = (S)-Canadine + NADP+ +
            2 H2O
SUBSTRATE   (S)-Tetrahydrocolumbamine
            NADPH
            O2
PRODUCT     (S)-Canadine
            NADP+
            H2O
COFACTOR    Heme-thiolate(P-450)
COMMENT     Catalyses an oxidative reaction that does not incorporate oxygen
            into the product.
            Oxidation of the methoxyphenol group of the alkaloid.
            tetrahydrocolumbamine results in the formation of the
            methylenedioxy bridge of canadine.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.36
            ExPASy - ENZYME nomenclature database: 1.1.3.36
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.36
///
ENTRY       EC 1.1.3.37
NAME        D-Arabinono-1,4-lactone oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    D-Arabinono-1,4-lactone + O2 = D-erythro-Ascorbate + H2O2
SUBSTRATE   D-Arabinono-1,4-lactone
            O2
PRODUCT     D-erythro-Ascorbate
            H2O2
COFACTOR    FAD
GENES       SCE: YML086C(ALO1)
MOTIF       PS: PS00862  P-x(10)-[DE]-[LIVM]-x(3)-[LIVM]-x(9)-[LIVM]-x(3)-[GSA]-
                         [GST]-G-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.37
            ExPASy - ENZYME nomenclature database: 1.1.3.37
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.37
///
ENTRY       EC 1.1.3.38
NAME        Vanillyl-alcohol oxidase
            4-Hydroxy-2-methoxybenzyl alcohol oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With oxygen as acceptor
REACTION    Vanillyl alcohol + O2 = Vanillin + H2O2
SUBSTRATE   Vanillyl alcohol
            O2
PRODUCT     Vanillin
            H2O2
COFACTOR    FAD
COMMENT     Converts a wide range of 4-hydroxybenzyl alcohols and
            4-hydroxybenzylamines into the corresponding aldehydes.
            The allyl group of 4-allylphenols is also converted into the
            -CH=CH-CH2OH group.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
STRUCTURES  PDB: 1E8G  1E0Y  1DZN  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.3.38
            ExPASy - ENZYME nomenclature database: 1.1.3.38
            WIT (What Is There) Metabolic Reconstruction: 1.1.3.38
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.3.38
            SCOP (Structural Classification of Proteins): 1.1.3.38
///
ENTRY       EC 1.1.4.1
NAME        Vitamin-K-epoxide reductase (warfarin-sensitive)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a disulfide as acceptor
SYSNAME     2-Methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol
            $ oxidoreductase
REACTION    2-Methyl-3-phytyl-1,4-naphthoquinone + Oxidized dithiothreitol +
            H2O =
            2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone +
            1,4-Dithiothreitol
SUBSTRATE   2-Methyl-3-phytyl-1,4-naphthoquinone
            Oxidized dithiothreitol
            H2O
            Vitamin K
            Vitamin K hydroquinone
PRODUCT     2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone
            1,4-Dithiothreitol
            Vitamin K 2,3-epoxide
INHIBITOR   Warfarin
COMMENT     In the reverse reaction, vitamin K 2,3-epoxide is reduced to
            vitamin K and possibly to vitamin K hydroquinone by
            1,4-dithiothreitol, which is oxidized to a disulfide; some other
            dithiols and 4-butanethiol can also act.  Inhibited strongly by
            warfarin (cf. EC 1.1.4.2).
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.4.1
            ExPASy - ENZYME nomenclature database: 1.1.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.4.1
            BRENDA, the Enzyme Database: 1.1.4.1
///
ENTRY       EC 1.1.4.2
NAME        Vitamin-K-epoxide reductase (warfarin-insensitive)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a disulfide as acceptor
SYSNAME     3-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:
            $oxidized-dithiothreitol oxidoreductase
REACTION    2-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone +
            Oxidized dithiothreitol + H2O =
            2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone +
            1,4-Dithiothreitol
SUBSTRATE   2-Hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
            Oxidized dithiothreitol
            H2O
            3-Hydroxy-vitamin K
            2-Hydroxy-vitamin K
PRODUCT     2,3-Epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone
            1,4-Dithiothreitol
            Vitamin K 2,3-epoxide
COMMENT     In the reverse reaction, vitamin K 2,3-epoxide is reduced to
            3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol,
            which is oxidized to a disulfide.  Not inhibited by warfarin
            (cf. 1.1.4.1).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.4.2
            ExPASy - ENZYME nomenclature database: 1.1.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.4.2
            BRENDA, the Enzyme Database: 1.1.4.2
///
ENTRY       EC 1.1.5.1
NAME        Cellobiose dehydrogenase (quinone)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With a quinone or similar compound as acceptor
SYSNAME     Cellobiose:quinone 1-oxidoreductase
REACTION    Cellobiose + a Quinone = Cellobiono-1,5-lactone + a Phenol
SUBSTRATE   Cellobiose
            Quinone
PRODUCT     Cellobiono-1,5-lactone
            Phenol
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Also acts, more slowly, on
            cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose,
            but not cellulose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.5.1
            ExPASy - ENZYME nomenclature database: 1.1.5.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.5.1
            BRENDA, the Enzyme Database: 1.1.5.1
///
ENTRY       EC 1.1.99.1
NAME        Choline dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Choline:(acceptor) 1-oxidoreductase
REACTION    Choline + Acceptor = Betaine aldehyde + Reduced acceptor
SUBSTRATE   Choline
            Acceptor
PRODUCT     Betaine aldehyde
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b0311(betA)
            ECE: Z0398(betA)
            ECS: ECs0357
            YPE: YPO1165(betA)
            PAE: PA5372(betA)
            MLO: mll7609
            SME: SMc00093(betA)
            CCR: CC2642
            SAU: SA2405(betA)
            SAV: SAV2596(betA)
            CEL: C34C6.4
MOTIF       PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.1
            ExPASy - ENZYME nomenclature database: 1.1.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.1
            BRENDA, the Enzyme Database: 1.1.99.1
///
ENTRY       EC 1.1.99.2
NAME        2-Hydroxyglutarate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     (S)-2-Hydroxyglutarate:(acceptor) 2-oxidoreductase
REACTION    (S)-2-Hydroxyglutarate + Acceptor = 2-Oxoglutarate +
            Reduced acceptor
SUBSTRATE   (S)-2-Hydroxyglutarate
            Acceptor
PRODUCT     2-Oxoglutarate
            Reduced acceptor
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.2
            ExPASy - ENZYME nomenclature database: 1.1.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.2
            BRENDA, the Enzyme Database: 1.1.99.2
///
ENTRY       EC 1.1.99.3
NAME        Gluconate 2-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Gluconate:(acceptor) 2-oxidoreductase
REACTION    D-Gluconate + Acceptor = 2-Dehydro-D-gluconate + Reduced acceptor
SUBSTRATE   D-Gluconate
            Acceptor
PRODUCT     2-Dehydro-D-gluconate
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.3
            ExPASy - ENZYME nomenclature database: 1.1.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.3
            BRENDA, the Enzyme Database: 1.1.99.3
///
ENTRY       EC 1.1.99.4
NAME        Dehydrogluconate dehydrogenase
            Ketogluconate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + Acceptor = Glycerone phosphate +
            Reduced acceptor
SUBSTRATE   sn-Glycerol 3-phosphate
            Acceptor
PRODUCT     Glycerone phosphate
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.4
            ExPASy - ENZYME nomenclature database: 1.1.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.4
            BRENDA, the Enzyme Database: 1.1.99.4
///
ENTRY       EC 1.1.99.5
NAME        Glycerol-3-phosphate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
REACTION    sn-Glycerol 3-phosphate + Acceptor = Glycerone phosphate +
            Reduced acceptor
SUBSTRATE   sn-Glycerol 3-phosphate
            Acceptor
PRODUCT     Glycerone phosphate
            Reduced acceptor
COMMENT     Formerly EC 1.1.2.1.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b2241(glpA) b2242(glpB) b2243(glpC) b3426(glpD)
            ECE: Z3499(glpA) Z3500(glpB) Z3501(glpC) Z4786(glpD)
            ECS: ECs3126 ECs3127 ECs3128 ECs4269
            YPE: YPO3825(glpB) YPO3826(glpA) YPO3937(glpD)
            HIN: HI0683(glpC) HI0684(glpB) HI0685(glpA)
            PMU: PM1440(glpC) PM1441(glpB) PM1442(glpA)
            XFA: XF2266
            VCH: VCA0657 VCA0747 VCA0748 VCA0749
            PAE: PA3025 PA3584(glpD)
            MLO: mll0710 mlr7270
            SME: SMb20499 SMc01620(eryB) SMc02520(glpD)
            BSU: BG10188(glpD)
            BHA: BH1095(glpD)
            SAU: SA1142(glpD)
            SAV: SAV1288(glpD)
            LLA: L0013(glpD)
            SPY: SPy1683(glpO)
            SPN: SP2185
            CAC: CAC1322(glpA)
            MGE: MG039
            MPN: D09_orf384(glpD)
            MPU: MYPU_2640(glpD)
            MTU: Rv2249c(glpD1) Rv3302c(glpD2)
            MTC: MT2309 MT3401
            MLE: ML0713(glpD)
            BBU: BB0243(glpA)
            SYN: sll1085(glpD)
            DRA: DR1019
            TMA: TM1432
            AFU: AF1328(glpA)
            HAL: VNG1070G(gpdA1) VNG1969G(gpdA2) VNG1971G(gpdB) VNG1972G(gpdC)
            TAC: Ta0633
            TVO: TVG0875243
            PAB: PAB0183(glpA)
            APE: APE0309
            SSO: SSO2526(glpA) SSO2643(glpC)
            SCE: YIL155C(GUT2)
            SPO: GUT2(gut2)
            CEL: T25G3.4
            DME: CG2137 CG7311(BG:DS08249.2)
            MMU: 99778(Gdm1)
            HSA: 2820(GPD2)
DISEASE     MIM: 138430  Glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00977  [IV]-G-G-G-x(2)-G-[STACV]-G-x-A-x-D-x(3)-R-G
            PS: PS00978  G-G-K-x(2)-[GSTE]-Y-R-x(2)-A
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.5
            ExPASy - ENZYME nomenclature database: 1.1.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.5
            BRENDA, the Enzyme Database: 1.1.99.5
///
ENTRY       EC 1.1.99.6
NAME        D-2-Hydroxy-acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     (R)-2-Hydroxy-acid:(acceptor) 2-oxidoreductase
REACTION    (R)-Lactate + Acceptor = Pyruvate + Reduced acceptor
SUBSTRATE   (R)-Lactate
            Acceptor
PRODUCT     Pyruvate
            Reduced acceptor
COFACTOR    Zinc
            FAD
COMMENT     A zinc flavoprotein (FAD).  Acts on a variety of (R)-2-hydroxy
            acids.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.6
            ExPASy - ENZYME nomenclature database: 1.1.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.6
            BRENDA, the Enzyme Database: 1.1.99.6
///
ENTRY       EC 1.1.99.7
NAME        Lactate--malate transhydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     (S)-Lactate:oxaloacetate oxidoreductase
REACTION    (S)-Lactate + Oxaloacetate = Pyruvate + Malate
SUBSTRATE   (S)-Lactate
            Oxaloacetate
PRODUCT     Pyruvate
            Malate
COFACTOR    Nicotinamide D-ribonucleotide
COMMENT     Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to
            2-oxo acids.  It contains thightly bound nicotinamide nucleotide
            in its active centre.  This prosthetic group cannot be removed
            without denaturation of the protein.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.7
            ExPASy - ENZYME nomenclature database: 1.1.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.7
            BRENDA, the Enzyme Database: 1.1.99.7
///
ENTRY       EC 1.1.99.8
NAME        Alcohol dehydrogenase (acceptor)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Alcohol:(acceptor) oxidoreductase
REACTION    a Primary alcohol + Acceptor = an Aldehyde + Reduced acceptor
SUBSTRATE   Primary alcohol
            Acceptor
PRODUCT     Aldehyde
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein. Acts on a wide range of primary alcohols,
            including methanol (cf. EC 1.1.99.20).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00631  1,2-Dichloroethane degradation
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
            PATH: MAP00680  Methane metabolism
GENES       SME: SMb20173
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
            PS: PS00363  [DEN]-W-x(3)-G-[RK]-x(6)-[FYW]-S-x(4)-[LIVM]-N-x(2)-N-
                         V-x(2)-L-[RK]
            PS: PS00364  W-x(4)-Y-D-x(3)-[DN]-[LIVMFY](4)-x(2)-G-x(2)-[STA]-P
STRUCTURES  PDB: 8ADH  1G72  1H4I  1H4J  4AAH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.8
            ExPASy - ENZYME nomenclature database: 1.1.99.8
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.8
            UM-BBD (Biocatalysis/Biodegradation Database): 1.1.99.8
            BRENDA, the Enzyme Database: 1.1.99.8
            SCOP (Structural Classification of Proteins): 1.1.99.8
///
ENTRY       EC 1.1.99.9
NAME        Pyridoxine 5-dehydrogenase
            Pyridoxol-5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Alcohol:(acceptor) oxidoreductase
REACTION    a Primary alcohol + Acceptor = an Aldehyde + Reduced acceptor
SUBSTRATE   Primary alcohol
            Acceptor
PRODUCT     Aldehyde
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.  Acts on a wide range of primary alcohols,
            including methanol (cf. 1.1.99.20).
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.9
            ExPASy - ENZYME nomenclature database: 1.1.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.9
            BRENDA, the Enzyme Database: 1.1.99.9
///
ENTRY       EC 1.1.99.10
NAME        Glucose dehydrogenase (acceptor)
            Glucose dehydrogenase (Aspergillus)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Glucose:(acceptor) 1-oxidoreductase
REACTION    D-Glucose + Acceptor = D-Glucono-1,5-lactone + Reduced acceptor
SUBSTRATE   D-Glucose
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     D-Glucono-1,5-lactone
            Reduced acceptor
            2,6-Dichlorophenol-4-(p-benzoquinone imine)
COFACTOR    FAD
COMMENT     A glycoprotein containing one mole of FAD per mole of enzyme.
            2,6-Dichloroindophenol can act as acceptor.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       DME: CG1152(Gld)
MOTIF       PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.10
            ExPASy - ENZYME nomenclature database: 1.1.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.10
            BRENDA, the Enzyme Database: 1.1.99.10
///
ENTRY       EC 1.1.99.11
NAME        Fructose 5-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Fructose:(acceptor) 5-oxidoreductase
REACTION    D-Fructose + Acceptor = 5-Dehydro-D-fructose + Reduced acceptor
SUBSTRATE   D-Fructose
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     5-Dehydro-D-fructose
            Reduced acceptor
COMMENT     2,6-Dichloroindophenol can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.11
            ExPASy - ENZYME nomenclature database: 1.1.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.11
            BRENDA, the Enzyme Database: 1.1.99.11
///
ENTRY       EC 1.1.99.12
NAME        Sorbose dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     L-Sorbose:(acceptor) 5-oxidoreductase
REACTION    L-Sorbose + Acceptor = 5-Dehydro-D-fructose + Reduced acceptor
SUBSTRATE   L-Sorbose
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     5-Dehydro-D-fructose
            Reduced acceptor
COMMENT     2,6-Dichloroindophenol can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.12
            ExPASy - ENZYME nomenclature database: 1.1.99.12
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.12
            BRENDA, the Enzyme Database: 1.1.99.12
///
ENTRY       EC 1.1.99.13
NAME        Glucoside 3-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Aldohexoside:(acceptor) 3-oxidoreductase
REACTION    Sucrose + Acceptor =
            3-Dehydro-alpha-D-glucosyl-beta-D-fructofuranoside +
            Reduced acceptor
SUBSTRATE   Sucrose
            Acceptor
            D-Glucose
            D-Galactose
            D-Glucoside
            D-Galactoside
PRODUCT     3-Dehydro-alpha-D-glucosyl-beta-D-fructofuranoside
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  The enzyme acts on D-glucose, D-galactose,
            D-glucosides and D-galactosides, but D-glucosides react more
            rapidly than D-galactosides.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.13
            ExPASy - ENZYME nomenclature database: 1.1.99.13
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.13
            BRENDA, the Enzyme Database: 1.1.99.13
///
ENTRY       EC 1.1.99.14
NAME        Glycolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Glycolate:(acceptor) 2-oxidoreductase
REACTION    Glycolate + Acceptor = Glyoxylate + Reduced acceptor
SUBSTRATE   Glycolate
            Acceptor
            (R)-Lactate
            2,6-Dichloroindophenol
            Phenazine methosulfate
PRODUCT     Glyoxylate
            Reduced acceptor
COMMENT     Also acts on (R)-lactate.  2,6-Dichloroindophenol and phenazine
            methosulfate can act as acceptors.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.14
            ExPASy - ENZYME nomenclature database: 1.1.99.14
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.14
            BRENDA, the Enzyme Database: 1.1.99.14
///
ENTRY       EC 1.1.99.15
NAME        Transferred to EC 1.7.99.5
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
COMMENT     Transferred entry. Now EC 1.7.99.5 -
            5,10-Methylenetetrahydrofolate reductase (FADH2).
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.15
            ExPASy - ENZYME nomenclature database: 1.1.99.15
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.15
///
ENTRY       EC 1.1.99.16
NAME        Malate dehydrogenase (acceptor)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     (S)-Malate:(acceptor) oxidoreductase
REACTION    (S)-Malate + Acceptor = Oxaloacetate + Reduced acceptor
SUBSTRATE   (S)-Malate
            Acceptor
PRODUCT     Oxaloacetate
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b2210(yojH)
            ECE: Z3468(yojH)
            ECS: ECs3099
            XFA: XF0942
            PAE: PA3452(mqoA) PA4640(mqoB)
            NME: NMB2096
            NMA: NMA0333(mqo)
            HPY: HP0086
            HPJ: jhp0079
            CJE: Cj0393c
            BHA: BH3960
            SAU: SA2155 SA2400(mqo2)
            SAV: SAV2591
            MTU: Rv2852c
            MTC: MT2918
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.16
            ExPASy - ENZYME nomenclature database: 1.1.99.16
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.16
            BRENDA, the Enzyme Database: 1.1.99.16
///
ENTRY       EC 1.1.99.17
NAME        Glucose dehydrogenase (pyrroloquinoline-quinone)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Glucose:(pyrroloquinone-quinone) 1-oxidoreductase
REACTION    D-Glucose + Acceptor = D-Glucono-1,5-lactone +
            Reduced acceptor
SUBSTRATE   D-Glucose
            Acceptor
            Pyrroloquinoline quinone
PRODUCT     D-Glucono-1,5-lactone
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.
            Different from EC 1.1.99.10. PQQ enzyme.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b0124(gcd)
            ECE: Z0134(gcd)
            ECS: ECs0128
            PAE: PA2290(gcd)
            MLO: mll1500
            SME: SMc00110(gcd)
            SYN: slr1608(gdhB)
MOTIF       PS: PS00363  [DEN]-W-x(3)-G-[RK]-x(6)-[FYW]-S-x(4)-[LIVM]-N-x(2)-N-
                         V-x(2)-L-[RK]
            PS: PS00364  W-x(4)-Y-D-x(3)-[DN]-[LIVMFY](4)-x(2)-G-x(2)-[STA]-P
STRUCTURES  PDB: 1CQ1  1CRU  1QBI  1C9U  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.17
            ExPASy - ENZYME nomenclature database: 1.1.99.17
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.17
            BRENDA, the Enzyme Database: 1.1.99.17
            SCOP (Structural Classification of Proteins): 1.1.99.17
///
ENTRY       EC 1.1.99.18
NAME        Cellobiose dehydrogenase (acceptor)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Cellobiose:(acceptor) 1-oxidoreductase
REACTION    Cellobiose + Acceptor = Cellobiono-1,5-lactone + Reduced acceptor
SUBSTRATE   Cellobiose
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     Cellobiono-1,5-lactone
            Reduced acceptor
COMMENT     2,6-Dichloroindophenol can act as acceptor.  Also acts, more
            slowly, on cello-oligosaccharides, lactose and
            D-glucosyl-1,4-beta-D-mannose.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.18
            ExPASy - ENZYME nomenclature database: 1.1.99.18
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.18
            BRENDA, the Enzyme Database: 1.1.99.18
///
ENTRY       EC 1.1.99.19
NAME        Uracil dehydrogenase
            Uracil oxidase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Uracil:(acceptor) oxidoreductase
REACTION    Uracil + Acceptor = Barbiturate + Reduced acceptor
SUBSTRATE   Uracil
            Acceptor
            Thymine
PRODUCT     Barbiturate
            Reduced acceptor
COMMENT     Also oxidizes thymine.  The enzyme acts on the hydrated
            derivative of the substrate.  Formerly EC 1.2.99.1.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.19
            ExPASy - ENZYME nomenclature database: 1.1.99.19
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.19
            BRENDA, the Enzyme Database: 1.1.99.19
///
ENTRY       EC 1.1.99.20
NAME        Alkan-1-ol dehydrogenase (acceptor)
            Polyethylene glycol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Alkan-1-ol:(acceptor) oxidoreductase
REACTION    Primary alcohol + Acceptor = Aldehyde + Reduced acceptor
SUBSTRATE   Primary alcohol
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     Aldehyde
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.  Acts on C3-C16 linear-chain saturated primary
            alcohols, C4-C7 aldehyde, and non-ionic surfactants containing
            polyethylene glycol residues such as Tween 40 and 60, but not on
            methanol and only very slowly on ethanol.  2,6-Dichloroindophenol
            can act as acceptor.  cf. EC 1.1.99.8.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.20
            ExPASy - ENZYME nomenclature database: 1.1.99.20
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.20
            BRENDA, the Enzyme Database: 1.1.99.20
///
ENTRY       EC 1.1.99.21
NAME        D-Sorbitol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     D-Sorbitol:(acceptor) 1-oxidoreductase
REACTION    D-Sorbitol + Acceptor = L-Sorbose + Reduced acceptor
SUBSTRATE   D-Sorbitol
            Acceptor
PRODUCT     L-Sorbose
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.21
            ExPASy - ENZYME nomenclature database: 1.1.99.21
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.21
            BRENDA, the Enzyme Database: 1.1.99.21
///
ENTRY       EC 1.1.99.22
NAME        Glycerol dehydrogenase (acceptor)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Glycerol:(acceptor) 1-oxidoreductase
REACTION    Glycerol + Acceptor = Glycerone + Reduced acceptor
SUBSTRATE   Glycerol
            Acceptor
PRODUCT     Glycerone
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.  Also acts, more slowly, on a number of other
            polyols including D-sorbitol, D-arabitol, meso-erythritol,
            adonitol and propylene glycol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.22
            ExPASy - ENZYME nomenclature database: 1.1.99.22
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.22
            BRENDA, the Enzyme Database: 1.1.99.22
///
ENTRY       EC 1.1.99.23
NAME        Polyvinyl-alcohol dehydrogenase (acceptor)
            PVA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Polyvinyl-alcohol:(acceptor) oxidoreductase
REACTION    Polyvinyl alcohol + Acceptor = Oxidized polyvinyl alcohol +
            Reduced acceptor
SUBSTRATE   Polyvinyl alcohol
            Acceptor
            Phenazine methosulfate
            2,6-Dichloroindophenol
PRODUCT     Oxidized polyvinyl alcohol
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.  Phenazine methosulfate and
            2,6-dichloroindophenol can act as acceptors.  Also acts, more
            slowly, on 2-hexanol and some other secondary alcohols.
            cf. EC 1.1.99.8 and 1.1.99.20.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.23
            ExPASy - ENZYME nomenclature database: 1.1.99.23
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.23
            BRENDA, the Enzyme Database: 1.1.99.23
///
ENTRY       EC 1.1.99.24
NAME        Hydroxyacid--oxoacid transhydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     (S)-3-Hydroxybutanoate:2-oxoglutarate oxidoreductase
REACTION    (S)-3-Hydroxybutanoate + 2-Oxoglutarate = Acetoacetate +
            (R)-2-Hydroxyglutarate
SUBSTRATE   (S)-3-Hydroxybutanoate
            2-Oxoglutarate
            4-Hydroxybutanoate
            (R)-Hydroxyglutarate
            4-Oxobutanoate
PRODUCT     Acetoacetate
            (R)-2-Hydroxyglutarate
COMMENT     4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as
            donors; 4-oxobutanoate can also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.24
            ExPASy - ENZYME nomenclature database: 1.1.99.24
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.24
            BRENDA, the Enzyme Database: 1.1.99.24
///
ENTRY       EC 1.1.99.25
NAME        Quinate dehydrogenase (pyrroloquinoline-quinone)
            NAD(P)-independent quinate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     Quinate:pyrroloquinoline-quinone 5-oxidoreductase
REACTION    Quinate + Pyrroloquinoline-quinone = 5-Dehydroquinate +
            Reduced pyrroloquinoline-quinone
SUBSTRATE   Quinate
            PQQ
PRODUCT     5-Dehydroquinate
            PQQH2
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.25
            ExPASy - ENZYME nomenclature database: 1.1.99.25
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.25
            BRENDA, the Enzyme Database: 1.1.99.25
///
ENTRY       EC 1.1.99.26
NAME        3-Hydroxycyclohexanone dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
SYSNAME     3-Hydroxycyclohexanone:acceptor 1-oxidoreductase
REACTION    3-Hydroxycyclohexanone + Acceptor = Cyclohexane-1,3-dione +
            Reduced acceptor
SUBSTRATE   3-Hydroxycyclohexanone
            Acceptor
            2,6-Dichloroindophenol
            Methylene blue
PRODUCT     Cyclohexane-1,3-dione
            Reduced acceptor
COMMENT     2,6-Dichloroindophenol and methylene blue can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.26
            ExPASy - ENZYME nomenclature database: 1.1.99.26
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.26
            BRENDA, the Enzyme Database: 1.1.99.26
///
ENTRY       EC 1.1.99.27
NAME        (R)-Pantolactone dehydrogenase (flavin)
            2-Dehydropantolactone reductase (flavin)
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
REACTION    (R)-Pantolactone + Acceptor =
            2-Dehydropantolactone + Reduced acceptor
SUBSTRATE   (R)-Pantolactone
            Acceptor
PRODUCT     2-Dehydropantolactone
            Reduced acceptor
COMMENT     High specificity for (R)-Pantolactone.
            Phenazine methosulfate can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.27
            ExPASy - ENZYME nomenclature database: 1.1.99.27
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.27
///
ENTRY       EC 1.1.99.28
NAME        Clucose-Fructose oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-OH group of donors
            With other acceptors
REACTION    D-Glucose + D-Fructose = D-Gluconolactone + D-Sorbitol
SUBSTRATE   D-Glucose
            D-Fructose
PRODUCT     D-Gluconolactone
            D-Sorbitol
COMMENT     Mannose, Xylose, Galactose, 2-Deoxyglucose and L-Arabinose
            will function as aldosugar substrates, but with low affinities.
            The ketosugar substrate must be in the open-chain form.
            The apparent affinity for Fructose is low owing to the small
            fraction present in the open-chain form.
            Xylulose and Glycerone will replace but they are poor substrates.
            The enzyme from Z.Mobilis contains tightly-bound NADP.
STRUCTURES  PDB: 1OFG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.1.99.28
            ExPASy - ENZYME nomenclature database: 1.1.99.28
            WIT (What Is There) Metabolic Reconstruction: 1.1.99.28
            SCOP (Structural Classification of Proteins): 1.1.99.28
///
ENTRY       EC 1.2.1.1
NAME        Formaldehyde dehydrogenase (glutathione)
            Formic dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formaldehyde:NAD+ oxidoreductase (glutathione-formylating)
REACTION    Formaldehyde + Glutathione + NAD+ = S-Formylglutathione + NADH
SUBSTRATE   Formaldehyde
            Glutathione
            NAD+
            2-Oxoaldehyde
PRODUCT     S-Formylglutathione
            NADH
COMMENT     Some 2-oxoaldehydes are also oxidized. In the reverse direction,
            NADPH can replace NADH.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00680  Methane metabolism
GENES       ECO: b0356(adhC)
            ECE: Z0456(adhC)
            ECS: ECs0411
            YPE: YPO1502
            HIN: HI0185(adhC)
            PAE: PA3629(adhC)
            NME: NMB1304
            NMA: NMA1518(adhC)
            MLO: mlr0872
            SME: SMb20170(fdh) SMc01270(adhC1)
            CCR: CC2516 CC3029
            BSU: BG11902(adhB)
            BHA: BH1829(adhB)
            CAC: CAC3375
            MTU: Rv0761c(adhB)
            MTC: MT0786
            SYN: sll0990
            SSO: SSO0472(adh-1)
            SCE: YDL168W(SFA1)
            SPO: SPBC1539.07C(spbc1539.07c) SPCC13B11.04C
            DME: CG6598(Fdh)
            MMU: 87929(Adh5)
            HSA: 128(ADH5) 2223(FDH)
DISEASE     MIM: 103710  Alcohol dehydrogenase (class III), chi polypeptide
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
STRUCTURES  PDB: 1TEH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.1
            ExPASy - ENZYME nomenclature database: 1.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.1
            BRENDA, the Enzyme Database: 1.2.1.1
///
ENTRY       EC 1.2.1.2
NAME        Formate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formate:NAD+ oxidoreductasee
REACTION    Formate + NAD+ = CO2 + NADH
SUBSTRATE   Formate
            NAD+
PRODUCT     CO2
            NADH
COMMENT     Together with EC 1.12.1.2, forms a system previously known as
            formate hydrogenlyase.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
GENES       ECO: b1474(fdnG) b1475(fdnH) b1476(fdnI) b3892(fdoI) b3893(fdoH)
                 b3894(fdoG) b4079(fdhF)
            ECE: Z2234(fdnI) Z2235(fdnH) Z2236(fdnG) Z5434(fdoI) Z5435(fdoH)
                 Z5436(fdoG) Z5678(fdhF)
            ECS: ECs2078 ECs2079 ECs2080 ECs4818 ECs4819 ECs4820 ECs5061
            YPE: YPO0344(fdhF) YPO4058(fdoG)
            HIN: HI0006 HI0007(fdxH) HI0008(fdxI)
            PMU: PM0406(fdxI) PM0407(fdxH) PM0408(fdxG_1) PM0409(fdxG_2)
            VCH: VC1511 VC1512
            PAE: PA4810(fdnI) PA4811(fdnH)
            CJE: Cj1509c(fdhC) Cj1510c(fdhB) Cj1511c(fdhA)
            MLO: mll5393 mll5396 mll5397 mll5398
            SME: SMa0002(fdoG) SMa0005(fdoH) SMa0007(fdoI) SMc02524(fdsG)
                 SMc02525(fdsB) SMc03086(fdsD) SMc04444(fdsA)
            ATU: AGR_L_346
            BSU: BG12294(yrhE) BG13190(yjgC) BG13476(yoaE)
            BHA: BH2530 BH2853
            SAU: SA2102
            SAV: SAV2294
            AAE: aq_1039(fdoG) aq_1046(fdoH) aq_1049(fdoI)
            MJA: MJ0005 MJ0006 MJ0155
            MTH: MTH1139 MTH1140 MTH1552 MTH1714 MTH1736 MTH1737
            TAC: Ta0045 Ta0425
            TVO: TVG0003442 TVG0257496
            PHO: PH0893 PH1353
            PAB: PAB1389 PAB1390 PAB2442(fdhA-like)
            APE: APE2556
            SSO: SSO1029(fdhF-1) SSO2824(fdhF-2)
            STO: ST0081
            SCE: YPL275W(YPL275W) YPL276W(YPL276W)
MOTIF       PS: PS00065  [LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-
                         G-x(13,14)-[LIVMFT]-x(2)-[FYWCTH]-[DNSTK]
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00490  [STA]-x-[STAC](2)-x(2)-[STA]-D-[LIVMY](2)-L-P-x-
                         [STAC](2)-x(2)-E
            PS: PS00551  [STAN]-x-[CH]-x(2,3)-C-[STAG]-[GSTVMF]-x-C-x-[LIVMFYW]-
                         x-[LIVMA]-x(3,4)-[DENQKHT]
            PS: PS00670  [LIVMFYWA]-[LIVFYWC]-x(2)-[SAC]-[DNQHR]-[IVFA]-[LIVF]-
                         x-[LIVF]-[HNI]-x-P-x(4)-[STN]-x(2)-[LIVMF]-x-[GSDN]
            PS: PS00671  [LMFATC]-[KPQ]-x-[GSTDN]-x-[LIVMFYWR]-[LIVMFYW](2)-N-x-
                         [STAGC]-R-[GP]-x-[LIVH]-[LIVMC]-[DNV]
            PS: PS00932  A-x(3)-[GDT]-I-x-[DNQTK]-x-[DEA]-x-[LIVM]-x-[LIVMC]-x-
                         [NS]-x(2)-[GS]-x(5)-A-x-[LIVM]-[ST]
STRUCTURES  PDB: 1AA6  1FDI  1FDO  2NAC  2NAD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.2
            ExPASy - ENZYME nomenclature database: 1.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.2
            BRENDA, the Enzyme Database: 1.2.1.2
            SCOP (Structural Classification of Proteins): 1.2.1.2
///
ENTRY       EC 1.2.1.3
NAME        Aldehyde dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aldehyde:NAD+ oxidoreductase
REACTION    Aldehyde + NAD+ + H2O = Carboxylate + NADH
SUBSTRATE   Aldehyde
            D-Glucuronolactone
            NAD+
            H2O
PRODUCT     Carboxylate
            D-Glucarate
            NADH
COMMENT     Wide specificity, including oxidation of D-glucuronolactone
            to D-glucarate. Formerly EC 1.1.1.70
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00053  Ascorbate and aldarate metabolism
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00310  Lysine degradation
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00631  1,2-Dichloroethane degradation
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1300(aldH)
            ECE: Z2488(aldH)
            ECS: ECs1877
            VCH: VC0819 VC1819 VCA1067
            PAE: PA0219 PA0366 PA1027 PA1984 PA4022 PA4073 PA4189 PA4899
                 PA5312
            MLO: mll1015 mll2219 mll2319 mll2867 mll6639 mll7045 mlr3049
                 mlr4051 mlr5236 mlr6969
            SME: SMa1844 SMb21301
            CCR: CC0419 CC0822 CC1216 CC3141
            BSU: BG10604(ywdH) BG11159(ycbD) BG11355(aldX) BG11903(aldY)
                 BG12582(dhaS)
            BHA: BH0539(dhaS) BH0681(aldA) BH0865 BH1005 BH2010
            SAU: SA0162(aldA) SA1736(aldH) SA1924
            SAV: SAV0162 SAV1905(aldH) SAV2109
            MTU: Rv0147 Rv0223c Rv0458 Rv0768(aldA) Rv3293(aldB)
            MTC: MT0155 MT0233 MT0474 MT0792 MT3392
            MLE: ML2639
            SYN: slr0091
            DRA: DRA0126 DRA0348
            AAE: aq_186(aldH1) aq_227(aldH2)
            HAL: VNG0771G(aldY2) VNG2513G(aldY1)
            TAC: Ta0439
            TVO: TVG1110903
            SSO: SSO3117(aldhT)
            SCE: YER073W(ALD3) YOR374W(ALD4) YPL061W(ALD6)
            SPO: SPAC922.07C(spac922.07c) SPAC9E9.09C(spac9e9.09c)
            ATH: At1g23820(F5O8.38)
            CEL: F54D8.3 T05H4.13 T08B1.3
            DME: CG3752 CG6309
            MMU: 99552(Ssdh1) 99598(Aldh4) 99599(Aldh3) 99601(Aldh1)
            HSA: 216(ALDH1A1) 217(ALDH2) 219(ALDH1B1) 223(ALDH9A1)
                 224(ALDH3A2) 8854(ALDH1A2)
DISEASE     MIM: 100640  Aldehyde dehydrogenase-1, soluble
            MIM: 100650  Aldehyde dehydrogenase-2, mitochondrial
            MIM: 100670  Aldehyde dehydrogenase-5
            MIM: 270200  Aldehyde dehydrogenase-10 (fatty aldehyde
                         dehydrogenase)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
STRUCTURES  PDB: 1A4Z  1AG8  1BXS  1CW3  1OM2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.3
            ExPASy - ENZYME nomenclature database: 1.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.3
            BRENDA, the Enzyme Database: 1.2.1.3
            SCOP (Structural Classification of Proteins): 1.2.1.3
///
ENTRY       EC 1.2.1.4
NAME        Aldehyde dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aldehyde:NADP+ oxidoreductase
REACTION    an Aldehyde + NADP+ + H2O = an Acid + NADPH
SUBSTRATE   Aldehyde
            NADP+
            H2O
PRODUCT     Acid
            NADPH
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.4
            ExPASy - ENZYME nomenclature database: 1.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.4
            BRENDA, the Enzyme Database: 1.2.1.4
///
ENTRY       EC 1.2.1.5
NAME        Aldehyde dehydrogenase (NAD(P)+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aldehyde:NAD(P)+ oxidoreductase
REACTION    an Aldehyde + NAD+ or NADP+ + H2O = an Acid + NADH or NADPH
SUBSTRATE   Aldehyde
            NADP+
            NAD+
            H2O
PRODUCT     Acid
            NADPH
            NADH
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
GENES       SCE: YMR169C(ALD3) YMR170C(ALD2)
            HSA: 218(ALDH3A1) 220(ALDH1A3) 221(ALDH3B1) 222(ALDH3B2)
DISEASE     MIM: 100660  Aldehyde dehydrogenase-3
            MIM: 600463  Aldehyde dehydrogenase-6
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
STRUCTURES  PDB: 1AD3  1EYY  1EZ0  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.5
            ExPASy - ENZYME nomenclature database: 1.2.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.5
            BRENDA, the Enzyme Database: 1.2.1.5
            SCOP (Structural Classification of Proteins): 1.2.1.5
///
ENTRY       EC 1.2.1.6
NAME        Deleted entry
            Benzaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.6
            ExPASy - ENZYME nomenclature database: 1.2.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.6
///
ENTRY       EC 1.2.1.7
NAME        Benzaldehyde dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Benzaldehyde:NADP+ oxidoreductase
REACTION    Benzaldehyde + NADP+ + H2O = Benzoate + NADPH
SUBSTRATE   Benzaldehyde
            NADP+
            H2O
PRODUCT     Benzoate
            NADPH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
            PATH: MAP00624  Xylene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.7
            ExPASy - ENZYME nomenclature database: 1.2.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.7
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.7
            BRENDA, the Enzyme Database: 1.2.1.7
///
ENTRY       EC 1.2.1.8
NAME        Betaine-aldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Betaine-aldehyde:NAD+ oxidoreductase
REACTION    Betaine aldehyde + NAD+ + H2O = Betaine + NADH
SUBSTRATE   Betaine aldehyde
            NAD+
            H2O
PRODUCT     Betaine
            NADH
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b0312(betB) b1444
            ECE: Z0399(betB) Z2275
            ECS: ECs0358 ECs2048
            YPE: YPO1166(betB)
            PAE: PA3504 PA5373(betB)
            MLO: mll7608 mlr5385
            SME: SMa1731(betB2) SMc00094(betB)
            BSU: BG11940(gbsA)
            BHA: BH0203(gbsA)
            SAU: SA2406(gbsA)
            SAV: SAV2597(gbsA)
            TVO: TVG0388541
            CEL: F42G9.5
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
STRUCTURES  PDB: 1A4S  1BPW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.8
            ExPASy - ENZYME nomenclature database: 1.2.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.8
            BRENDA, the Enzyme Database: 1.2.1.8
            SCOP (Structural Classification of Proteins): 1.2.1.8
///
ENTRY       EC 1.2.1.9
NAME        Glyceraldehyde-3-phosphate dehydrogenase (NADP+)
            Triosephosphate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glyceraldehyde-3-phosphate:NADP+ oxidoreductase
REACTION    D-Glyceraldehyde 3-phosphate + NADP+ + H2O =
            3-Phospho-D-glycerate + NADPH
SUBSTRATE   D-Glyceraldehyde 3-phosphate
            NADP+
            H2O
PRODUCT     3-Phospho-D-glycerate
            NADPH
GENES       BHA: BH1738 BH2237(gapN)
            SPY: SPy1371(gapN)
            SPN: SP1119
            SPR: spr1028(gapN)
            CAC: CAC3657
            MJA: MJ1411(gapN)
            MTH: MTH978
            HAL: VNG0937G(gap)
            APE: APE1786
            SSO: SSO1629(gapN-1) SSO1842(gapN-2) SSO3194(gapN-3)
            STO: ST0064
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
STRUCTURES  PDB: 1EUH  1QI1  1QI6  2EUH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.9
            ExPASy - ENZYME nomenclature database: 1.2.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.9
            BRENDA, the Enzyme Database: 1.2.1.9
            SCOP (Structural Classification of Proteins): 1.2.1.9
///
ENTRY       EC 1.2.1.10
NAME        Acetaldehyde dehydrogenase (acetylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
REACTION    Acetaldehyde + CoA + NAD+ = Acetyl-CoA + NADH
SUBSTRATE   Acetaldehyde
            CoA
            NAD+
PRODUCT     Acetyl-CoA
            NADH
COMMENT     Also acts, more slowly, on glycolaldehyde, propanal and butanal.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b0351(mhpF) b1241(adhE)
            ECE: Z0450(mhpF) Z2016(adhE)
            ECS: ECs0406 ECs1741
            PMU: PM1453(adh2)
            VCH: VC2033
            SAU: SA0143(adhE)
            SAV: SAV0142(adh2)
            LLA: L13145(adhE)
            SPN: SP2026
            MTU: Rv3535c
            MTC: MT3639
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.10
            ExPASy - ENZYME nomenclature database: 1.2.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.10
            BRENDA, the Enzyme Database: 1.2.1.10
///
ENTRY       EC 1.2.1.11
NAME        Aspartate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
REACTION    L-Aspartate 4-semialdehyde + Orthophosphate + NADP+ =
            L-4-Aspartyl phosphate + NADPH
SUBSTRATE   L-Aspartate 4-semialdehyde
            Orthophosphate
            NADP+
PRODUCT     L-4-Aspartyl phosphate
            NADPH
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b3433(asd)
            ECE: Z4797(asd)
            ECS: ECs4278
            YPE: YPO2765(asd)
            HIN: HI0646(asd)
            PMU: PM1632(asd)
            XFA: XF1371
            VCH: VC2036 VC2107
            PAE: PA3116 PA3117(asd)
            BUC: BU448(asd)
            NME: NMB2079
            NMA: NMA0351
            HPY: HP1189(asd)
            HPJ: jhp1114
            CJE: Cj1023c(asd)
            RPR: RP316(asd)
            RCO: RC0430(asd)
            MLO: mll4392
            SME: SMc04410(asd)
            CCR: CC0253 CC3485
            BSU: BG10783(asd)
            BHA: BH2401(asd)
            SAU: SA1226(asd)
            SAV: SAV1379(asd)
            LLA: L66199(asd)
            SPN: SP1013
            SPR: spr0918(asd)
            CAC: CAC0022(asd) CAC0568(asd)
            MTU: Rv3708c(asd)
            MTC: MT3811
            MLE: ML2322(asd)
            CTR: CT363
            CMU: TC0642
            CPN: CPn1048
            CPA: CP0804
            CPJ: asd
            SYN: slr0549(asd)
            DRA: DR2008
            AAE: aq_1866(asd)
            TMA: TM1523
            MJA: MJ0205(asd)
            MTH: MTH799
            AFU: AF1506(asd)
            HAL: VNG1435G(asd)
            TAC: Ta0363
            PHO: PH1088
            PAB: PAB1678(asd)
            APE: APE1143
            SSO: SSO0874(asd-1) SSO2178(asd-2)
            STO: ST1242
            SCE: YDR158W(HOM2)
            SPO: SPCC1827.06C(spcc1827.06c)
            ATH: At1g14810(F10B6.22)
MOTIF       PS: PS01103  [LIVM]-[SADN]-x(2)-C-x-R-[LIVM]-x(4)-[GSC]-H-[STA]
STRUCTURES  PDB: 1BRM  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.11
            ExPASy - ENZYME nomenclature database: 1.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.11
            BRENDA, the Enzyme Database: 1.2.1.11
            SCOP (Structural Classification of Proteins): 1.2.1.11
///
ENTRY       EC 1.2.1.12
NAME        Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
            Triosephosphate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase(phosphorylating)
REACTION    D-Glyceraldehyde 3-phosphate + Orthophosphate + NAD+ =
            3-Phospho-D-glyceroyl phosphate + NADH
SUBSTRATE   D-Glyceraldehyde 3-phosphate
            D-Glyceraldehyde
            Orthophosphate
            Thiol
            NAD+
PRODUCT     3-Phospho-D-glyceroyl phosphate
            NADH
COMMENT     Also acts very slowly on D-glyceraldehyde and some other
            aldehydes; thiols can replace phosphate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
GENES       ECO: b1416(gapC_2) b1417(gapC) b1779(gapA)
            ECE: Z2304(gapC) Z2818(gapA)
            ECS: ECs2022 ECs2488
            YPE: YPO2157(gapA)
            HIN: HI0001(gapA)
            PMU: PM0924(gapdH)
            XFA: XF0457
            VCH: VC1069 VC2000
            PAE: PA3195
            BUC: BU298(gapA)
            NME: NMB0207 NMB2159
            NMA: NMA0062(gapA) NMA0246
            HPY: HP0921(gapa) HP1346(gap)
            HPJ: jhp0855 jhp1265
            CJE: Cj1403c(gapA)
            MLO: mlr3750
            SME: SMc03979(gap)
            CCR: CC3248
            BSU: BG10827(gapA) BG12592(gapB)
            BHA: BH3149(gapB) BH3560(gap)
            SAU: SA0727(gap) SA1510(gapB)
            SAV: SAV0759(gap) SAV1673(gapB)
            LLA: L0004(gapA) L0005(gapB)
            SPY: SPy0274(plr)
            SPN: SP2012
            SPR: spr1825(gapA)
            CAC: CAC0709(gapC)
            MGE: MG301(gapa)
            MPN: A05_orf337(gap)
            MPU: MYPU_0460(gap)
            MTU: Rv1436(gap)
            MTC: MT1480
            MLE: ML0570(gap)
            CTR: CT505
            CMU: TC0792
            CPN: CPn0624
            CPA: CP0123
            CPJ: gapA
            BBU: BB0057(gap)
            TPA: TP0844
            SYN: slr0884(gap1)
            DRA: DR1343
            AAE: aq_1065(gap)
            TMA: TM0688
            MJA: MJ1146
            MTH: MTH1009
            AFU: AF1732(gap)
            HAL: VNG0095G(gapB)
            TAC: Ta1103
            TVO: TVG0444310
            PHO: PH1830
            PAB: PAB0257(gap)
            APE: APE0171
            SSO: SSO0528(gap)
            STO: ST1356
            SCE: YGR192C(TDH3) YJL052W(TDH1) YJR009C(TDH2)
            SPO: GPD1_2(gpd1) TDH1(tdh1)
            CEL: gpd-1 gpd-2 gpd-3 gpd-4
            DME: CG12055(Gapdh1) CG8893(Gapdh2)
            HSA: 2597(GAPD) 26330(GAPDS)
DISEASE     MIM: 138400  Glyceraldehyde-3-phosphate dehydrogenase
MOTIF       PS: PS00071  [ASV]-S-C-[NT]-T-x(2)-[LIM]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 4GPD  1DC5  1GAD  1GAE  1GYP  1GYQ  1HDG  1I32  1A7K  1B7G  
                 1CER  1CF2  1CRW  1DBV  1DC3  1DC4  1I33  1DC6  1DSS  1SZJ  
                 1GD1  1GGA  1GPD  4DBV  3GPD  3DBV  2GD1  2DBV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.12
            ExPASy - ENZYME nomenclature database: 1.2.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.12
            BRENDA, the Enzyme Database: 1.2.1.12
            SCOP (Structural Classification of Proteins): 1.2.1.12
///
ENTRY       EC 1.2.1.13
NAME        Glyceraldehyde-3-phosphate dehydrogenase (NADP+)(phosphorylating)
            Triosephosphate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     D-Glyceraldehyde-3-phosphate:NADP+ oxidoreductase(phosphorylating)
REACTION    D-Glyceraldehyde 3-phosphate + Orthophosphate + NADP+ =
            3-Phospho-D-glyceroyl phosphate + NADPH
SUBSTRATE   D-Glyceraldehyde 3-phosphate
            Orthophosphate
            NADP+
PRODUCT     3-Phospho-D-glyceroyl phosphate
            NADPH
PATHWAY     PATH: MAP00710  Carbon fixation
STRUCTURES  PDB: 1NLH  1NLG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.13
            ExPASy - ENZYME nomenclature database: 1.2.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.13
            BRENDA, the Enzyme Database: 1.2.1.13
            SCOP (Structural Classification of Proteins): 1.2.1.13
///
ENTRY       EC 1.2.1.14
NAME        Transferred to EC 1.1.1.205
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.1.1.205 - IMP dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.14
            ExPASy - ENZYME nomenclature database: 1.2.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.14
///
ENTRY       EC 1.2.1.15
NAME        Malonate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Oxopropanoate:NAD(P)+ oxidoreductase
REACTION    3-Oxopropanoate + NAD+ or NADP+ + H2O = Malonate + NADH or NADPH
SUBSTRATE   3-Oxopropanoate
            NAD+
            NADP+
            H2O
PRODUCT     Malonate
            NADH
            NADPH
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.15
            ExPASy - ENZYME nomenclature database: 1.2.1.15
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.15
            BRENDA, the Enzyme Database: 1.2.1.15
///
ENTRY       EC 1.2.1.16
NAME        Succinate-semialdehyde dehydrogenase (NAD(P)+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Succinate-semialdehyde:NAD(P)+ oxidoreductase
REACTION    Succinate semialdehyde + NAD+ or NADP+ + H2O = Succinate +
            NADH or NADPH
SUBSTRATE   Succinate semialdehyde
            NAD+
            NADP+
            H2O
PRODUCT     Succinate
            NADH
            NADPH
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b2661(gabD)
            ECE: Z3959(gabD)
            ECS: ECs3522
            PMU: PM1536(attK)
            VCH: VC1745
            PAE: PA0265(gabD)
            NME: NMB1488(NADP+)
            NMA: NMA1696(gabD)
            RCO: RC0621(gabD)
            MLO: mll1168 mll5719 mll5809 mll7043 mll7128
            SME: SMa0805(gabD4) SMa1848(gabD5) SMb21185(gabD2) SMc02780(gabD1)
            CCR: CC3140
            BSU: BG12044(gabD)
            BHA: BH0995 BH3316(gabD)
            SPY: SPy1067(gabD)
            MTU: Rv0234c(gabD2) Rv1731(gabD1)
            MTC: MT0245 MT1772
            MLE: ML2573(gabD)
            SYN: slr0370(gabD)
            DRA: DRA0003 DRA0343
            HAL: VNG0808G(gabD)
            SCE: YBR006W
            SPO: SPAC1002.12C(spac1002.12c) SPAC139.05(spac139.05)
            CEL: F45H10.1
            DME: CG4685
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.16
            ExPASy - ENZYME nomenclature database: 1.2.1.16
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.16
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.16
            BRENDA, the Enzyme Database: 1.2.1.16
///
ENTRY       EC 1.2.1.17
NAME        Glyoxylate dehydrogenase (acylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glyoxylate:NADP+ oxidoreductase (CoA-oxalylating)
REACTION    Glyoxylate + CoA + NADP+ = Oxalyl-CoA + NADPH
SUBSTRATE   Glyoxylate
            CoA
            NADP+
PRODUCT     Oxalyl-CoA
            NADPH
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.17
            ExPASy - ENZYME nomenclature database: 1.2.1.17
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.17
            BRENDA, the Enzyme Database: 1.2.1.17
///
ENTRY       EC 1.2.1.18
NAME        Malonate-semialdehyde dehydrogenase (acetylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating,
            CoA-acetylating)
REACTION    3-Oxopropanoate + CoA + NAD+ or NADP+ = Acetyl-CoA + CO2 +
            NADH or NADPH
SUBSTRATE   3-Oxopropanoate
            CoA
            NAD+
            NADP+
PRODUCT     Acetyl-CoA
            CO2
            NADH
            NADPH
PATHWAY     PATH: MAP00031  Inositol metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00641  3-Chloroacrylic acid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.18
            ExPASy - ENZYME nomenclature database: 1.2.1.18
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.18
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.18
            BRENDA, the Enzyme Database: 1.2.1.18
///
ENTRY       EC 1.2.1.19
NAME        Aminobutyraldehyde dehydrogenase
            gamma-Guanidinobutyraldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Aminobutanal:NAD+ 1-oxidoreductase
REACTION    4-Aminobutanal + NAD+ + H2O = 4-Aminobutanoate + NADH
SUBSTRATE   4-Aminobutanal
            NAD+
            H2O
PRODUCT     4-Aminobutanoate
            NADH
COMMENT     The plant enzyme also acts on 4-guanidinobutanal
            (cf. EC 1.2.1.54).
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       HSA: 223(ALDH9A1)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.19
            ExPASy - ENZYME nomenclature database: 1.2.1.19
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.19
            BRENDA, the Enzyme Database: 1.2.1.19
///
ENTRY       EC 1.2.1.20
NAME        Glutarate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glutarate-semialdehyde:NAD+ oxidoreductase
REACTION    Glutarate semialdehyde + NAD+ + H2O = Glutarate + NADH
SUBSTRATE   Glutarate semialdehyde
            NAD+
            H2O
PRODUCT     Glutarate
            NADH
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.20
            ExPASy - ENZYME nomenclature database: 1.2.1.20
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.20
            BRENDA, the Enzyme Database: 1.2.1.20
///
ENTRY       EC 1.2.1.21
NAME        Glycolaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycolaldehyde:NAD+ oxidoreductase
REACTION    Glycolaldehyde + NAD+ + H2O = Glycolate + NADH
SUBSTRATE   Glycolaldehyde
            NAD+
            H2O
PRODUCT     Glycolate
            NADH
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.21
            ExPASy - ENZYME nomenclature database: 1.2.1.21
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.21
            BRENDA, the Enzyme Database: 1.2.1.21
///
ENTRY       EC 1.2.1.22
NAME        Lactaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Lactaldehyde:NAD+ oxidoreductase
REACTION    (S)-Lactaldehyde + NAD+ + H2O = (S)-Lactate + NADH
SUBSTRATE   (S)-Lactaldehyde
            NAD+
            H2O
PRODUCT     (S)-Lactate
            NADH
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b1415(aldA) b3588(aldB)
            ECE: Z2306(aldA) Z5008(aldB)
            ECS: ECs2021 ECs4464
            NME: NMB1968
            NMA: NMA0480(aldA)
            CJE: Cj0489(ald') Cj0490(ald')
            CCR: CC3580
            TAC: Ta0809
            TVO: TVG1076124
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.22
            ExPASy - ENZYME nomenclature database: 1.2.1.22
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.22
            BRENDA, the Enzyme Database: 1.2.1.22
///
ENTRY       EC 1.2.1.23
NAME        2-Oxoaldehyde dehydrogenase (NAD+)
            alpha-Ketoaldehyde dehydrogenase
            Methylglyoxal dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Oxoaldehyde:NAD+ 2-oxidoreductase
REACTION    a 2-Oxoaldehyde + NAD+ + H2O = a 2-Oxo acid + NADH
SUBSTRATE   2-Oxoaldehyde
            NAD+
            H2O
PRODUCT     2-Oxo acid
            NADH
COMMENT     Not identical with EC 1.2.1.49.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.23
            ExPASy - ENZYME nomenclature database: 1.2.1.23
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.23
            BRENDA, the Enzyme Database: 1.2.1.23
///
ENTRY       EC 1.2.1.24
NAME        Succinate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Succinate-semialdehyde:NAD+ oxidoreductase
REACTION    Succinate semialdehyde + NAD+ + H2O = Succinate + NADH
SUBSTRATE   Succinate semialdehyde
            NAD+
            H2O
PRODUCT     Succinate
            NADH
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       HSA: 7915(ALDH5A1)
DISEASE     MIM: 271980  Succinic semialdehyde dehydrogenase
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.24
            ExPASy - ENZYME nomenclature database: 1.2.1.24
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.24
            BRENDA, the Enzyme Database: 1.2.1.24
///
ENTRY       EC 1.2.1.25
NAME        2-Oxoisovalerate dehydrogenase (acylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Methyl-2-oxobutanoate:NAD+ oxidoreductase
            (CoA-mehtylpropanoylating)
REACTION    3-Methyl-2-oxobutanoate + CoA + NAD+ = 2-Methylpropanoyl-CoA +
            CO2 + NADH
SUBSTRATE   3-Methyl-2-oxobutanoate
            (S)-3-Methyl-2-oxopentanoate
            4-Methyl-2-oxopentanoate
            CoA
            NAD+
PRODUCT     2-Methylpropanoyl-CoA
            CO2
            NADH
COMMENT     Also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-
            2-oxopentanoate
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.25
            ExPASy - ENZYME nomenclature database: 1.2.1.25
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.25
            BRENDA, the Enzyme Database: 1.2.1.25
///
ENTRY       EC 1.2.1.26
NAME        2,5-Dioxovalerate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,5-Dioxopentanoate:NADP+ 5-oxidoreductase
REACTION    2,5-Dioxopentanoate + NADP+ + H2O = 2-Oxoglutarate + NADPH
SUBSTRATE   2,5-Dioxopentanoate
            NADP+
            H2O
PRODUCT     2-Oxoglutarate
            NADPH
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.26
            ExPASy - ENZYME nomenclature database: 1.2.1.26
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.26
            BRENDA, the Enzyme Database: 1.2.1.26
///
ENTRY       EC 1.2.1.27
NAME        Methylmalonate-semialdehyde dehydrogenase (acylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Methyl-3-oxopropanoate:NAD+ oxidoreductase
            (CoA-propanoylating)
REACTION    2-Methyl-3-oxopropanoate + CoA + NAD+ = Propanoyl-CoA +
            CO2 + NADH
SUBSTRATE   2-Methyl-3-oxopropanoate
            CoA
            NAD+
            Propanal
PRODUCT     Propanoyl-CoA
            CO2
            NADH
COMMENT     Also converts propanal to propanoyl-CoA.
PATHWAY     PATH: MAP00031  Inositol metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00640  Propanoate metabolism
GENES       PAE: PA0130 PA0747 PA3570(mmsA)
            MLO: mll3987
            CCR: CC1302 CC2274
            BSU: BG11117(iolA)
            BHA: BH2312
            MTU: Rv0753c(mmsA)
            MTC: MT0777
            SSO: SSO1218
            STO: ST1116
            CEL: F13D12.4
            DME: CG17896(EG:171D11.1) CG17896_1(EG:171D11.1)
            HSA: 4329(ALDH6A1)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.27
            ExPASy - ENZYME nomenclature database: 1.2.1.27
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.27
            BRENDA, the Enzyme Database: 1.2.1.27
///
ENTRY       EC 1.2.1.28
NAME        Benzaldehyde dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Benzaldehyde:NAD+ oxidoreductase
REACTION    Benzaldehyde + NAD+ + H2O = Benzoate + NADH
SUBSTRATE   Benzaldehyde
            NAD+
            H2O
PRODUCT     Benzoate
            NADH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
            PATH: MAP00624  Xylene degradation
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.28
            ExPASy - ENZYME nomenclature database: 1.2.1.28
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.28
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.28
            BRENDA, the Enzyme Database: 1.2.1.28
///
ENTRY       EC 1.2.1.29
NAME        Aryl-aldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aryl-aldehyde:NAD+ oxidoreductase
REACTION    an Aromatic aldehyde + NAD+ + H2O = an Aromatic acid + NADH
SUBSTRATE   Aromatic aldehyde
            NAD+
            H2O
PRODUCT     Aromatic acid
            NADH
COMMENT     Oxidizes a number of aromatic aldehydes, but not aliphatic
            aldehydes.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00621  Biphenyl degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.29
            ExPASy - ENZYME nomenclature database: 1.2.1.29
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.29
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.29
            BRENDA, the Enzyme Database: 1.2.1.29
///
ENTRY       EC 1.2.1.30
NAME        Aryl-aldehyde dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)
REACTION    an Aromatic aldehyde + NADP+ + AMP + Pyrophosphate + H2O =
            an Aromatic acid + NADPH + ATP
SUBSTRATE   Aromatic aldehyde
            NADP+
            AMP
            Pyrophosphate
            H2O
PRODUCT     Aromatic acid
            NADPH
            ATP
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.30
            ExPASy - ENZYME nomenclature database: 1.2.1.30
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.30
            BRENDA, the Enzyme Database: 1.2.1.30
///
ENTRY       EC 1.2.1.31
NAME        L-Aminoadipate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-2-Aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
REACTION    L-2-Aminoadipate 6-semialdehyde + NAD+ or NADP+ + H2O =
            L-2-Aminoadipate + NADH or NADPH
SUBSTRATE   L-2-Aminoadipate 6-semialdehyde
            NADP+
            NAD+
            H2O
PRODUCT     L-2-Aminoadipate
            NADPH
            NADH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00310  Lysine degradation
GENES       SCE: YBR115C(LYS2) YGL154C(LYS5)
            SPO: LYS1(lys1)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.31
            ExPASy - ENZYME nomenclature database: 1.2.1.31
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.31
            BRENDA, the Enzyme Database: 1.2.1.31
///
ENTRY       EC 1.2.1.32
NAME        Aminomuconate-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase
REACTION    2-Aminomuconate 6-semialdehyde + NAD+ + H2O =
            2-Aminomuconate + NADH
SUBSTRATE   2-Aminomuconate 6-semialdehyde
            NAD+
            H2O
            2-Hydroxymuconate semialdehyde
PRODUCT     2-Aminomuconate
            NADH
            2-Hydroxymuconate
COMMENT     Also acts on 2-hydroxymuconate semialdehyde.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.32
            ExPASy - ENZYME nomenclature database: 1.2.1.32
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.32
            BRENDA, the Enzyme Database: 1.2.1.32
///
ENTRY       EC 1.2.1.33
NAME        (R)-Dehydropantoate dehydrogenase
            D-Aldopantoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (R)-4-Dehydropantoate:NAD+ 4-oxidoreductase
REACTION    (R)-4-Dehydropantoate + NAD+ + H2O = (R)-3,3-Dimethylmalate + NADH
SUBSTRATE   (R)-4-Dehydropantoate
            NAD+
            H2O
PRODUCT     (R)-3,3-Dimethylmalate
            NADH
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.33
            ExPASy - ENZYME nomenclature database: 1.2.1.33
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.33
            BRENDA, the Enzyme Database: 1.2.1.33
///
ENTRY       EC 1.2.1.34
NAME        Transferred to EC 1.1.1.131
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now included with EC 1.1.1.131 -
            Mannuronate reductase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.34
            ExPASy - ENZYME nomenclature database: 1.2.1.34
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.34
///
ENTRY       EC 1.2.1.35
NAME        Transferred to EC 1.1.1.203
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.1.1.203 - Uronate dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.35
            ExPASy - ENZYME nomenclature database: 1.2.1.35
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.35
///
ENTRY       EC 1.2.1.36
NAME        Retinal dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Retinal:NAD+ oxidoreductase
REACTION    Retinal + NAD+ + H2O = Retinoate + NADH
SUBSTRATE   Retinal
            NAD+
            H2O
PRODUCT     Retinoate
            NADH
COFACTOR    FAD
            Metal
COMMENT     A metalloflavoprotein (FAD).  Acts on both the 11-trans- and 13-
            cis-forms of retinal.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.36
            ExPASy - ENZYME nomenclature database: 1.2.1.36
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.36
            BRENDA, the Enzyme Database: 1.2.1.36
///
ENTRY       EC 1.2.1.37
NAME        Transferred to EC 1.1.1.204
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.1.1.204 - Xanthine dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.37
            ExPASy - ENZYME nomenclature database: 1.2.1.37
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.37
///
ENTRY       EC 1.2.1.38
NAME        N-Acetyl-gamma-glutamyl-phosphate reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-Acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase
            (phosphrylating)
REACTION    N-Acetyl-L-glutamate 5-semialdehyde + NADP+ + Orthophosphate =
            N-Acetyl-L-glutamate 5-phosphate + NADPH
SUBSTRATE   N-Acetyl-L-glutamate 5-semialdehyde
            NADP+
            Orthophosphate
PRODUCT     N-Acetyl-L-glutamate 5-phosphate
            NADPH
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b3958(argC)
            ECE: Z5516(argC)
            ECS: ECs4887
            YPE: YPO3927(argC)
            PMU: PM1118(argC)
            XFA: XF1002
            VCH: VC2644
            PAE: PA0662(argC)
            BUC: BU048(argC)
            NME: NMB1787
            NMA: NMA0676(argC)
            CJE: Cj0224(argC)
            MLO: mll8452
            SME: SMc01801(argC)
            CCR: CC1378
            BSU: BG10191(argC)
            BHA: BH2900(argC)
            SAU: SA0178(argC)
            SAV: SAV0179(argC)
            LLA: L0104(argC)
            CAC: CAC2390(argC)
            MTU: Rv1652(argC)
            MTC: MT1690
            MLE: ML1406(argC)
            SYN: sll0080(argC)
            DRA: DR0078 DR0963
            AAE: aq_1879(argC)
            TMA: TM1782
            MJA: MJ1096(argC)
            MTH: MTH846
            AFU: AF2071(argC)
            PHO: PH1720
            PAB: PAB0291(argC)
            APE: APE1462
            SSO: SSO0155(argC)
            STO: ST0195
            SCE: YER069W(ARG5)
MOTIF       PS: PS01224  [LIVMA]-[GSA]-x-[PA]-G-C-[FYN]-[AVP]-T-[GSAC]-x(3)-
                         [GTAC]-[LIVMCA]-x-P
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.38
            ExPASy - ENZYME nomenclature database: 1.2.1.38
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.38
            BRENDA, the Enzyme Database: 1.2.1.38
///
ENTRY       EC 1.2.1.39
NAME        Phenylacetaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Phenylacetaldehyde:NAD+ oxidoreductase
REACTION    Phenylacetaldehyde + NAD+ + H2O = Phenylacetate + NADH
SUBSTRATE   Phenylacetaldehyde
            NAD+
            H2O
PRODUCT     Phenylacetate
            NADH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00643  Styrene degradation
GENES       ECO: b1385(feaB)
            MTU: Rv2858c(aldC)
            MTC: MT2926
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.39
            ExPASy - ENZYME nomenclature database: 1.2.1.39
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.39
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.39
            BRENDA, the Enzyme Database: 1.2.1.39
///
ENTRY       EC 1.2.1.40
NAME        3alpha,7alpha,12alpha-Trihydroxycholestan-26-al
            $ 26-oxidoreductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al:NAD+
            $ 26-oxidoreductase
REACTION    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al + NAD+ +
            H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oate +
            NADH
SUBSTRATE   3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al
            NAD+
            H2O
PRODUCT     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oate
            NADH
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.40
            ExPASy - ENZYME nomenclature database: 1.2.1.40
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.40
            BRENDA, the Enzyme Database: 1.2.1.40
///
ENTRY       EC 1.2.1.41
NAME        Glutamate-5-semialdehyde dehydrogenase
            beta-Glutamylphosphate reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate-5-semialdehyde:NADP+ 5-oxidoreductase
            (phosphorylationg)
REACTION    L-Glutamate 5-semialdehyde + Orthophosphate + NADP+ =
            L-Glutamyl 5-phosphate + NADPH
SUBSTRATE   L-Glutamate 5-semialdehyde
            Orthophosphate
            NADP+
PRODUCT     L-Glutamyl 5-phosphate
            NADPH
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b0243(proA)
            ECE: Z0304(proA)
            ECS: ECs0270
            YPE: YPO3221(proA)
            HIN: HI1239(proA)
            PMU: PM0936(proA)
            XFA: XF1005
            VCH: VC2273
            PAE: PA4007(proA)
            NME: NMB1068
            NMA: NMA1267(proA)
            CJE: Cj0558c(proA)
            MLO: mll4009
            SME: SMc03777(proA)
            CCR: CC3430
            BSU: BG10964(proA)
            BHA: BH1504
            LLA: L0116(proA)
            SPY: SPy1670(proA)
            SPN: SP0932
            SPR: spr0833(proA)
            CAC: CAC3254(proA)
            MTU: Rv2427c(proA)
            MTC: MT2500
            MLE: ML1458(proA)
            TPA: TP0350
            SYN: sll0373(proA) sll0461(proA)
            DRA: DR1826
            AAE: aq_1071(proA)
            TMA: TM0293
            SCE: YOR323C(PRO2)
            SPO: SPAC821.11(spac821.11)
            ATH: At2g39800(T5I7.10)
            CEL: T22H6.2
            DME: CG7470
            HSA: 5832(PYCS)
MOTIF       PS: PS00902  [GSTN]-x(2)-G-x-G-[GC]-[IM]-x-[STA]-K-[LIVM]-x-[SA]-
                         [TCA]-x(2)-[GALV]
            PS: PS01223  V-x(5)-A-[LIV]-x-H-I-x(2)-[HY]-[GS]-[ST]-x-H-[ST]-[DE]-
                         x-I
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.41
            ExPASy - ENZYME nomenclature database: 1.2.1.41
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.41
            BRENDA, the Enzyme Database: 1.2.1.41
///
ENTRY       EC 1.2.1.42
NAME        Hexadecanal dehydrogenase (acylating)
            Fatty acyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hexadecanal:NAD+ oxidoreductase (CoA-acylating)
REACTION    Hexadecanal + CoA + NAD+ = Hexadecanoyl-CoA + NADH
SUBSTRATE   Hexadecanal
            CoA
            NAD+
PRODUCT     Hexadecanoyl-CoA
            NADH
COMMENT     Also acts, more slowly, on octadecanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.42
            ExPASy - ENZYME nomenclature database: 1.2.1.42
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.42
            BRENDA, the Enzyme Database: 1.2.1.42
///
ENTRY       EC 1.2.1.43
NAME        Formate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formate:NADP+ oxidoreductase
REACTION    Formate + NADP+ = CO2 + NADPH
SUBSTRATE   Formate
            NADP+
PRODUCT     CO2
            NADPH
COFACTOR    Tungsten
            Selenium
            Iron
COMMENT     A tungsten-selenium-iron protein.
            Selenocysteine-140 is coded by a stop codon, TGA (Ziononi
            et al. Proc. Natl. Acad. Sci. USA, 84, 3156-3160, 1987).
            Complementary tRNA is coded on a gene selC of E. coli.
            First serine-tRNA is formed by serine-tRNA ligase, then
            modified to selenocystein-tRNA (Leinfelder et al. Nature,
            331, 723-725, 1988).
PATHWAY     PATH: MAP00680  Methane metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.43
            ExPASy - ENZYME nomenclature database: 1.2.1.43
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.43
            BRENDA, the Enzyme Database: 1.2.1.43
///
ENTRY       EC 1.2.1.44
NAME        Cinnamoyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)
REACTION    Cinnamaldehyde + CoA + NADP+ = Cinnamoyl-CoA + NADPH
SUBSTRATE   Cinnamaldehyde
            CoA
            NADP+
PRODUCT     Cinnamoyl-CoA
            NADPH
COMMENT     Acts also on a number of substituted cinnamoyl esters of
            coenzyme A.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.44
            ExPASy - ENZYME nomenclature database: 1.2.1.44
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.44
            BRENDA, the Enzyme Database: 1.2.1.44
///
ENTRY       EC 1.2.1.45
NAME        4-Carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+
            $ 6-oxidoreductase
REACTION    4-Carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde + NADP+ =
            4-Carboxy-2-hydroxy-cis,cis-muconate + NADPH
SUBSTRATE   4-Carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde
            NADP+
PRODUCT     4-Carboxy-2-hydroxy-cis,cis-muconate
            NADPH
COMMENT     The enzyme does not act on unsubstituted aliphatic or aromatic
            aldehydes or glucose; NAD+ can replace NADP+, but with lower
            affinity.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.45
            ExPASy - ENZYME nomenclature database: 1.2.1.45
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.45
            BRENDA, the Enzyme Database: 1.2.1.45
///
ENTRY       EC 1.2.1.46
NAME        Formaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formaldehyde:NAD+ oxidoreductase
REACTION    Formaldehyde + NAD+ + H2O = Formate + NADH
SUBSTRATE   Formaldehyde
            NAD+
            H2O
PRODUCT     Formate
            NADH
COMMENT     Unlike EC 1.2.1.1, this enzyme from Pseudomonas does not need
            reduced glutathione.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00059  G-H-E-x(2)-G-x(5)-[GA]-x(2)-[IVSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.46
            ExPASy - ENZYME nomenclature database: 1.2.1.46
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.46
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.46
            BRENDA, the Enzyme Database: 1.2.1.46
///
ENTRY       EC 1.2.1.47
NAME        4-Trimethylammoniobutyraldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Trimethylammoniobutanal:NAD+ 1-oxidoreductase
REACTION    4-Trimethylammoniobutanal + NAD+ = 4-Trimethylammoniobutanoate +
            NADH
SUBSTRATE   4-Trimethylammoniobutanal
            NAD+
PRODUCT     4-Trimethylammoniobutanoate
            NADH
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.47
            ExPASy - ENZYME nomenclature database: 1.2.1.47
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.47
            BRENDA, the Enzyme Database: 1.2.1.47
///
ENTRY       EC 1.2.1.48
NAME        Long-chain-aldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Long-chain-aldehyde:NAD+ oxidoreductase
REACTION    a Long-chain aldehyde + NAD+ = a Long-chain carboxylate + NADH
SUBSTRATE   Long-chain aldehyde
            NAD+
            Dodecylaldehyde
PRODUCT     Long-chain carboxylate
            NADH
            Dodecylcarboxylate
COMMENT     The best substrate is dodecylaldehyde.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.48
            ExPASy - ENZYME nomenclature database: 1.2.1.48
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.48
            BRENDA, the Enzyme Database: 1.2.1.48
///
ENTRY       EC 1.2.1.49
NAME        2-Oxoaldehyde dehydrogenase (NADP+)
            alpha-Ketoaldehyde dehydrogenase
            Methylglyoxal dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Oxoaldehyde:NADP+ oxidoreductase
REACTION    a 2-Oxoaldehyde + NADP+ + H2O = a 2-Oxo acid + NADPH
SUBSTRATE   2-Oxoaldehyde
            NADP+
            H2O
PRODUCT     2-Oxo acid
            NADPH
COMMENT     Not identical with EC 1.2.1.23.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.49
            ExPASy - ENZYME nomenclature database: 1.2.1.49
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.49
            BRENDA, the Enzyme Database: 1.2.1.49
///
ENTRY       EC 1.2.1.50
NAME        Long-chain-fatty-acyl-CoA reductase
            Acyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)
REACTION    a Long-chain aldehyde + CoA + NADP+ = a Long-chain acyl-CoA +
            NADPH
SUBSTRATE   Long-chain aldehyde
            CoA
            NADP+
PRODUCT     Long-chain acyl-CoA
            NADPH
COMMENT     Together with EC 6.2.1.19 forms a fatty acid reductase system
            which produces the substrate of EC 1.14.14.3, thus being part of
            the bacterial luciferase system.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.50
            ExPASy - ENZYME nomenclature database: 1.2.1.50
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.50
            BRENDA, the Enzyme Database: 1.2.1.50
///
ENTRY       EC 1.2.1.51
NAME        Pyruvate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
REACTION    Pyruvate + CoA + NADP+ = Acetyl-CoA + CO2 + NADPH
SUBSTRATE   Pyruvate
            CoA
            NADP+
            FAD
            Methyl viologen
PRODUCT     Acetyl-CoA
            CO2
            NADPH
INHIBITOR   O2
COMMENT     The Euglena enzyme can also use FAD or methyl viologen as
            acceptor, more slowly. The enzyme is inhibited by oxygen.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.51
            ExPASy - ENZYME nomenclature database: 1.2.1.51
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.51
            BRENDA, the Enzyme Database: 1.2.1.51
///
ENTRY       EC 1.2.1.52
NAME        Oxoglutarate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating)
REACTION    2-Oxoglutarate + CoA + NADP+ = Succinyl-CoA + CO2 + NADPH
SUBSTRATE   2-Oxoglutarate
            CoA
            NADP+
PRODUCT     Succinyl-CoA
            CO2
            NADPH
COMMENT     The Euglena enzyme can also use NAD+ as acceptor, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.52
            ExPASy - ENZYME nomenclature database: 1.2.1.52
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.52
            BRENDA, the Enzyme Database: 1.2.1.52
///
ENTRY       EC 1.2.1.53
NAME        4-Hydroxyphenylacetaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Hydroxyphenylacetaldehyde:NAD+ oxidoreductase
REACTION    4-Hydroxyphenylacetaldehyde + NAD+ = 4-Hydroxyphenylacetate + NADH
SUBSTRATE   4-Hydroxyphenylacetaldehyde
            NAD+
PRODUCT     4-Hydroxyphenylacetate
            NADH
COMMENT     With EC 4.2.1.87, brings about the metabolism of octopamine in
            Pseudomonas.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.53
            ExPASy - ENZYME nomenclature database: 1.2.1.53
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.53
            BRENDA, the Enzyme Database: 1.2.1.53
///
ENTRY       EC 1.2.1.54
NAME        gamma-Guanidinobutyraldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Guanidinobutanal:NAD+ 1-oxidoreductase
REACTION    4-Guanidinobutanal + NAD+ = 4-Guanidinobutanoate + NADH
SUBSTRATE   4-Guanidinobutanal
            NAD+
PRODUCT     4-Guanidinobutanoate
            NADH
COMMENT     Involved in the degradation of arginine in Pseudomonas putida.
            (cf. EC 1.2.1.19).
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.54
            ExPASy - ENZYME nomenclature database: 1.2.1.54
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.54
            BRENDA, the Enzyme Database: 1.2.1.54
///
ENTRY       EC 1.2.1.55
NAME        (R)-3-Hydroxyacid ester dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase
REACTION    Ethyl (R)-3-hydroxyhexanoate + NADP+ = Ethyl 3-oxohexanoate +
            NADPH
SUBSTRATE   Ethyl (R)-3-hydroxyhexanoate
            NADP+
            Ethyl (R)-3-hydroxybutanoate
PRODUCT     Ethyl 3-oxohexanoate
            NADPH
            Ethyl 3-oxobutanoate
COMMENT     Also acts on ethyl (R)-3-oxobutanoate and some other
            (R)-3-hydroxy acid esters.  The (R)- symbol is allotted on the
            assumption that no substituents change the order of priority from
            O-3>C-2>C-4.  A subunit of yeast fatty acid synthase
            (EC 2.3.1.86).
            cf. EC 1.2.1.56.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.55
            ExPASy - ENZYME nomenclature database: 1.2.1.55
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.55
            BRENDA, the Enzyme Database: 1.2.1.55
///
ENTRY       EC 1.2.1.56
NAME        (S)-3-Hydroxyacid ester dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase
REACTION    Ethyl (S)-3-hydroxyhexanoate + NADP+ = Ethyl 3-oxohexanoate +
            NADPH
SUBSTRATE   Ethyl (S)-3-hydroxyhexanoate
            NADP+
PRODUCT     Ethyl 3-oxohexanoate
            NADPH
COMMENT     Also acts on 4-oxo- and 5-oxo-fatty acids and their esters.
            cf. 1.2.1.55.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.56
            ExPASy - ENZYME nomenclature database: 1.2.1.56
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.56
            BRENDA, the Enzyme Database: 1.2.1.56
///
ENTRY       EC 1.2.1.57
NAME        Butanal dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Butanal:NAD(P)+ oxidoreductase (CoA-acylating)
REACTION    Butanal + CoA + NAD+ or NADP+ = Butanoyl-CoA + NADH or NADPH
SUBSTRATE   Butanal
            CoA
            NAD+
            NADP+
PRODUCT     Butanoyl-CoA
            NADH
            NADPH
COMMENT     Also acts on acetaldehyde, more slowly.
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.57
            ExPASy - ENZYME nomenclature database: 1.2.1.57
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.57
///
ENTRY       EC 1.2.1.58
NAME        Phenylglyoxylate dehydrogenase (acylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
REACTION    Phenylglyoxylate + NAD+ + CoA = Benzoyl-CoA + CO2 + NADH
SUBSTRATE   Phenylglyoxylate
            NAD+
            CoA
PRODUCT     Benzoyl-CoA
            CO2
            NADH
COFACTOR    Thiamin diphosphate
            FAD
COMMENT     The enzyme from Azoarcus evansii is specific for phenylglyoxylate
            2-oxoisovalerate is oxidised at 15% of the rate for
            phenylglyoxylate. Also reduces viologen dyes.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.58
            ExPASy - ENZYME nomenclature database: 1.2.1.58
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.58
///
ENTRY       EC 1.2.1.59
NAME        Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)
            NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
            Triosephosphate dehydrogenase (NAD(P))
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
REACTION    D-Glyceraldehyde 3-phosphate + Phosphate + NAD+ or NADP+ =
            3-Phospho-D-glyceroyl phosphate + NADH or NADPH
SUBSTRATE   D-Glyceraldehyde 3-phosphate
            Phosphate
            NAD+
            NADP+
PRODUCT     3-Phospho-D-glyceroyl phosphate
            NADH
            NADPH
COMMENT     NAD and NADP can be used as cofactors with similar efficiency,
            unlike EC 1.2.1.12 and EC 1.2.1.13, which are NAD- and
            NADP-dependent, respectively.
GENES       SYN: sll1342(gap2)
MOTIF       PS: PS00071  [ASV]-S-C-[NT]-T-x(2)-[LIM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.59
            ExPASy - ENZYME nomenclature database: 1.2.1.59
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.59
///
ENTRY       EC 1.2.1.60
NAME        5-Carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
            Carboxymethylhydroxymuconic semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5-Carboxymethyl-2-hydroxymuconic-semialdehyde:NAD oxidoreductase
REACTION    5-Carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD =
            5-Carboxymethyl-2-hydroxymuconate + NADH
SUBSTRATE   5-Carboxymethyl-2-hydroxymuconate semialdehyde
            H2O
            NAD
PRODUCT     5-Carboxymethyl-2-hydroxymuconate
            NADH
COMMENT     Involved in the tyrosine degradation pathway in Arthrobacter sp.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       PMU: PM1530(hpaE)
            PAE: PA4123(hpcC)
            DRA: DRA0220
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.60
            ExPASy - ENZYME nomenclature database: 1.2.1.60
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.60
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.60
///
ENTRY       EC 1.2.1.61
NAME        4-Hydroxymuconic semialdehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Hydroxymuconic-semialdehyde:NAD oxidoreductase
REACTION    4-Hydroxymuconic semialdehyde + NAD + H2O = Maleylacetate + NADH
SUBSTRATE   4-Hydroxymuconic semialdehyde
            NAD
            H2O
PRODUCT     Maleylacetate
            NADH
COMMENT     Involved in the 4-nitrophenol degradation pathway.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.61
            ExPASy - ENZYME nomenclature database: 1.2.1.61
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.61
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.61
///
ENTRY       EC 1.2.1.62
NAME        4-Formylbenzenesulfonate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Formylbenzenesulfonate:NAD oxidoreductase
REACTION    4-Formylbenzenesulfonate + NAD + H2O = 4-Sulfobenzoate + NADH
SUBSTRATE   4-Formylbenzenesulfonate
            NAD
            H2O
PRODUCT     4-Sulfobenzoate
            NADH
COMMENT     Involved in the toluene-4-sulfonate degradation pathway.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.62
            ExPASy - ENZYME nomenclature database: 1.2.1.62
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.62
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.62
///
ENTRY       EC 1.2.1.63
NAME        6-Oxohexanoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     6-Oxohexanoate:NADP oxidoreductase
REACTION    6-Oxohexanoate + NADP + H2O = Adipate + NADPH
SUBSTRATE   6-Oxohexanoate
            NADP
            H2O
PRODUCT     Adipate
            NADPH
COMMENT     Last step in the cyclohexanol degradation pathway in Acinetobacter
            sp.
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.63
            ExPASy - ENZYME nomenclature database: 1.2.1.63
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.63
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.63
///
ENTRY       EC 1.2.1.64
NAME        4-Hydroxybenzaldehyde dehydrogenase
            p-Hydroxybenzaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Hydroxybenzaldehyde:NAD oxidoreductase
REACTION    4-Hydroxybenzaldehyde + NAD + H2O = 4-Hydroxybenzoate + NADH
SUBSTRATE   4-Hydroxybenzaldehyde
            NAD
            H2O
PRODUCT     4-Hydroxybenzoate
            NADH
COMMENT     Involved in the toluene degradation pathway in Pseudomonas
            mendocina.
PATHWAY     PATH: MAP00622  Toluene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.64
            ExPASy - ENZYME nomenclature database: 1.2.1.64
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.64
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.64
///
ENTRY       EC 1.2.1.65
NAME        Salicylaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Salicylaldehyde:NAD oxidoreductase
REACTION    Salicylaldehyde + NAD + H2O = Salicylate + NADH
SUBSTRATE   Salicylaldehyde
            NAD
            H2O
PRODUCT     Salicylate
            NADH
COMMENT     Involved in the naphthalene degradation pathway in some bacteria.
PATHWAY     PATH: MAP00626  Nitorobenzene degradation
GENES       MLO: mll7197
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.65
            ExPASy - ENZYME nomenclature database: 1.2.1.65
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.65
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.1.65
///
ENTRY       EC 1.2.1.66
NAME        Mycothiol-dependent formaldehyde dehydrogenase
            NAD/factor-dependent formaldehyde dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Formaldehyde:NAD oxidoreductase (mycothiol-formylating)
REACTION    Formaldehyde + Mycothiol + NAD = S-Formylmycothiol + NADH
SUBSTRATE   Formaldehyde
            Mycothiol
            NAD
PRODUCT     S-Formylmycothiol
            NADH
COMMENT     A similar reaction to that of EC 1.2.1.1 [formaldehyde
            dehydrogenase (glutathione)], except that mycothiol {1-O-[2-(N-
            acetyl-L-cysteinamido)-2-deoxy-a-D-glucopyranosyl]-D-myo-inositol}
            replaces glutathione. The S-formylmycothiol formed hydrolyses to
            mycothiol and formate.
GENES       MTU: Rv2259(adhE2)
            MTC: MT2320
            MLE: ML1784(adhE2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.1.66
            ExPASy - ENZYME nomenclature database: 1.2.1.66
            WIT (What Is There) Metabolic Reconstruction: 1.2.1.66
///
ENTRY       EC 1.2.2.1
NAME        Formate dehydrogenase (cytochrome)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a cytochrome as acceptor
SYSNAME     Formate:ferricytochrome-b1 oxidoreductase
REACTION    Formate + Ferricytochrome b1 = CO2 + Ferrocytochrome b1
SUBSTRATE   Formate
            Ferricytochrome b1
PRODUCT     CO2
            Ferrocytochrome b1
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.2.1
            ExPASy - ENZYME nomenclature database: 1.2.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.2.1
            BRENDA, the Enzyme Database: 1.2.2.1
///
ENTRY       EC 1.2.2.2
NAME        Pyruvate dehydrogenase (cytochrome)
            Pyruvate dehydrogenase
            Pyruvic dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a cytochrome as acceptor
SYSNAME     Pyruvate:ferricytochrome-b1 oxidoreductase
REACTION    Pyruvate + Ferricytochrome b1 + H2O = Acetate + CO2 +
            Ferrocytochrome b1
SUBSTRATE   Pyruvate
            Ferricytochrome b1
            H2O
PRODUCT     Acetate
            CO2
            Ferrocytochrome b1
COFACTOR    Thiamine diphosphate
            FAD
COMMENT     A flavoprotein requiring thiamine diphosphate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0871(poxB)
            ECE: Z1105(poxB)
            ECS: ECs0957
            YPE: YPO1358(poxB)
            PAE: PA5297(poxB)
            TAC: Ta0816
            SSO: SSO1012(ilvB-3) SSO2962(ilvB-5)
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.2.2
            ExPASy - ENZYME nomenclature database: 1.2.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.2.2
            BRENDA, the Enzyme Database: 1.2.2.2
///
ENTRY       EC 1.2.2.3
NAME        Formate dehydrogenase (cytochrome c-553)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a cytochrome as acceptor
SYSNAME     Formate:ferricytochrome-c-553 oxidoreductase
REACTION    Formate + Ferricytochrome c-553 = CO2 + Ferrocytochrome c-553
SUBSTRATE   Formate
            Ferricytochrome c-553
            Yeast cytochrome c
            Ferricyanide
            Phenazine methosulfate
PRODUCT     CO2
            Ferrocytochrome c-553
COMMENT     Yeast cytochrome c, ferricyanide and phenazine methosulfate can
            act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.2.3
            ExPASy - ENZYME nomenclature database: 1.2.2.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.2.3
            BRENDA, the Enzyme Database: 1.2.2.3
///
ENTRY       EC 1.2.2.4
NAME        Carbon monoxide oxygenase (Cytochrome b-561)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a cytochrome as acceptor
REACTION    CO + H2O + Ferrocytochrome b-561 =
            CO2 + 2 H+ + Ferricytochrome b-561
SUBSTRATE   CO
            H2O
            Ferrocytochrome b-561
PRODUCT     CO2
            H+
            Ferricytochrome b-561
COMMENT     Methylene blue and Iodonitrotetrazolium chloride can act as
            artifical electron acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.2.4
            ExPASy - ENZYME nomenclature database: 1.2.2.4
            WIT (What Is There) Metabolic Reconstruction: 1.2.2.4
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.2.4
///
ENTRY       EC 1.2.3.1
NAME        Aldehyde oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Aldehyde:oxygen oxidoreductase
REACTION    an Aldehyde + H2O + O2 = an Acid + O2.-
SUBSTRATE   Aldehyde
            H2O
            O2
PRODUCT     Acid
            O2.-
COFACTOR    Molybdenum
            FAD
            Heme
COMMENT     A molybdenum flavohemoprotein.  Also oxidizes quinoline and
            pyridine derivatives.  May be identical with EC 1.1.3.22.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00750  Vitamin B6 metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       MMU: 88035(Aox1)
            HSA: 316(AOX1)
DISEASE     MIM: 602841  Aldehyde oxidase-1
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.1
            ExPASy - ENZYME nomenclature database: 1.2.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.1
            BRENDA, the Enzyme Database: 1.2.3.1
///
ENTRY       EC 1.2.3.2
NAME        Transferred to EC 1.1.3.22
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
COMMENT     Transferred entry. Now EC 1.1.3.22 - Xanthine oxidase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.2
            ExPASy - ENZYME nomenclature database: 1.2.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.2
///
ENTRY       EC 1.2.3.3
NAME        Pyruvate oxidase
            Pyruvic oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Pyruvate:oxygen 2-oxidoreductase (phosphorylating)
REACTION    Pyruvate + Orthophosphate + O2 + H2O = Acetyl phosphate + CO2 +
            H2O2
SUBSTRATE   Pyruvate
            Orthophosphate
            O2
            H2O
PRODUCT     Acetyl phosphate
            CO2
            H2O2
COFACTOR    FAD
            Thiamine diphosphate
COMMENT     A flavoprotein (FAD) requiring thiamine diphosphate. Sequence and
            functional similarity to acetolactate synthase (EC 4.1.3.18);
            Nature, 1988, 331, 360-362. Evolved from a common ancestor.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       BSU: BG12063(ydaP)
            SAU: SA2327
            SAV: SAV2522(poxB)
            LLA: L0199(poxL)
            SPN: SP0730
            SPR: spr0642(spxB)
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
STRUCTURES  PDB: 1POX  1POW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.3
            ExPASy - ENZYME nomenclature database: 1.2.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.3
            BRENDA, the Enzyme Database: 1.2.3.3
            SCOP (Structural Classification of Proteins): 1.2.3.3
///
ENTRY       EC 1.2.3.4
NAME        Oxalate oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Oxalate:oxygen oxidoreductase
REACTION    Oxalate + O2 = 2 CO2 + H2O2
SUBSTRATE   Oxalate
            O2
PRODUCT     CO2
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
MOTIF       PS: PS00725  G-x(4)-H-x-H-P-x-A-x-E-[LIVM]
STRUCTURES  PDB: 1FI2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.4
            ExPASy - ENZYME nomenclature database: 1.2.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.4
            BRENDA, the Enzyme Database: 1.2.3.4
///
ENTRY       EC 1.2.3.5
NAME        Glyoxylate oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Glyoxylate:oxygen oxidoreductase
REACTION    Glyoxylate + H2O + O2 = Oxalate + H2O2
SUBSTRATE   Glyoxylate
            H2O
            O2
PRODUCT     Oxalate
            H2O2
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.5
            ExPASy - ENZYME nomenclature database: 1.2.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.5
            BRENDA, the Enzyme Database: 1.2.3.5
///
ENTRY       EC 1.2.3.6
NAME        Pyruvate oxidase (CoA-acetylating)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
REACTION    Pyruvate + CoA + O2 = Acetyl-CoA + CO2 + H2O2
SUBSTRATE   Pyruvate
            CoA
            O2
PRODUCT     Acetyl-CoA
            CO2
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  May be identical with EC 1.2.7.1.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.6
            ExPASy - ENZYME nomenclature database: 1.2.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.6
            BRENDA, the Enzyme Database: 1.2.3.6
///
ENTRY       EC 1.2.3.7
NAME        Indole-3-acetaldehyde oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Indole-3-acetaldehyde:oxygen oxidoreductase
REACTION    2 Indole-3-acetaldehyde + O2 = 2 Indole-3-acetate + 2 H2O
SUBSTRATE   Indole-3-acetaldehyde
            O2
PRODUCT     Indole-3-acetate
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein.  Also oxidizes indole-3-aldehyde and acetaldehyde,
            more slowly.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.7
            ExPASy - ENZYME nomenclature database: 1.2.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.7
            BRENDA, the Enzyme Database: 1.2.3.7
///
ENTRY       EC 1.2.3.8
NAME        Pyridoxal oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Pyridoxal:oxygen 4-oxidoreductase
REACTION    Pyridoxal + H2O + O2 = 4-Pyridoxate + O2.-
SUBSTRATE   Pyridoxal
            H2O
            O2
PRODUCT     4-Pyridoxate
            O2.-
COFACTOR    Molybdenum
COMMENT     A molybdenum protein.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.8
            ExPASy - ENZYME nomenclature database: 1.2.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.8
            BRENDA, the Enzyme Database: 1.2.3.8
///
ENTRY       EC 1.2.3.9
NAME        Aryl-aldehyde oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Aryl-aldehyde:oxygen oxidoreductase
REACTION    an Aromatic aldehyde + O2 = an Aromatic acid + H2O2
SUBSTRATE   Aromatic aldehyde
            O2
            Benzaldehyde
            Vanillin
PRODUCT     Aromatic acid
            H2O2
            Benzoate
            Vanillate
COMMENT     Acts on benzaldehyde, vanillin and a number of other aromatic
            aldehydes, but not on aliphatic aldehydes or sugars.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.9
            ExPASy - ENZYME nomenclature database: 1.2.3.9
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.9
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.9
            BRENDA, the Enzyme Database: 1.2.3.9
///
ENTRY       EC 1.2.3.10
NAME        Carbon-monoxide oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Carbon-monoxide:oxygen oxidoreductase
REACTION    CO + H2O + O2 = CO2 + H2O2
SUBSTRATE   CO
            H2O
            O2
            Methylene blue
PRODUCT     CO2
            H2O2
COFACTOR    Iron
            Sulfur
            FAD
COMMENT     An iron-sulfur flavoprotein containing two molecules of
            molybdopterin per molecule.  Methylene blue can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.10
            ExPASy - ENZYME nomenclature database: 1.2.3.10
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.10
            BRENDA, the Enzyme Database: 1.2.3.10
///
ENTRY       EC 1.2.3.11
NAME        Retinal oxidase
            Retinene oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Retinal:oxygen oxidoreductase
REACTION    Retinal + O2 = Retinoate + H2O2
SUBSTRATE   Retinal
            O2
PRODUCT     Retinoate
            H2O2
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.11
            ExPASy - ENZYME nomenclature database: 1.2.3.11
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.11
            BRENDA, the Enzyme Database: 1.2.3.11
///
ENTRY       EC 1.2.3.12
NAME        Vanillate demethylase
            4-Hydroxy-3-methoxybenzoate demethylase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     Vanillate:oxygen oxidoreductase (demethylating)
REACTION    Vanillate + O2 + NADH = 3,4-Dihydroxybenzoate + NAD + H2O +
            Formaldehyde
SUBSTRATE   Vanillate
            O2
            NADH
PRODUCT     3,4-Dihydroxybenzoate
            NAD
            H2O
            Formaldehyde
COMMENT     Forms part of the vanillin degradation pathway in Arthrobacter sp.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.12
            ExPASy - ENZYME nomenclature database: 1.2.3.12
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.12
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.12
///
ENTRY       EC 1.2.3.13
NAME        4-Hydroxyphenylpyruvate oxidase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With oxygen as acceptor
SYSNAME     4-Hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
REACTION    4-Hydroxyphenylpyruvate + 1/2 O2 = 4-Hydroxyphenylacetate + CO2
SUBSTRATE   4-Hydroxyphenylpyruvate
            O2
PRODUCT     4-Hydroxyphenylacetate
            CO2
COMMENT     Involved in tyrosine degradation pathway in Arthrobacter sp.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.3.13
            ExPASy - ENZYME nomenclature database: 1.2.3.13
            WIT (What Is There) Metabolic Reconstruction: 1.2.3.13
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.13
///
ENTRY       EC 1.2.4.1
NAME        Pyruvate dehydrogenase (lipoamide)
            Pyruvate decarboxylase
            Pyruvate dehydrogenase
            Pyruvic dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a disulfide as acceptor
SYSNAME     Pyruvate:lipoamide 2-oxidoreductase(decarboxylating and
            acceptor-acetylating)
REACTION    Pyruvate + Lipoamide = S-Acetyldihydrolipoamide + CO2
SUBSTRATE   Pyruvate
            Lipoamide
PRODUCT     S-Acetyldihydrolipoamide
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     Requires thiamine diphosphate; component of the multienzyme
            pyruvate dehydrogenase complex.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b0114(aceE)
            ECE: Z0124(aceE)
            ECS: ECs0118
            YPE: YPO3419(aceE)
            HIN: HI1233(aceE)
            PMU: PM0895(aceE)
            XFA: XF0669
            VCH: VC2414
            PAE: PA3416 PA3417 PA4150 PA4151(acoB) PA5015(aceE)
            BUC: BU205(aceE)
            NME: NMB1341
            NMA: NMA1554(aceE)
            RPR: RP261(pdhA) RP262(pdhB)
            RCO: RC0347(pdhA) RC0348(pdhB)
            MLO: mll3628 mlr0383 mlr0384 mlr9539
            SME: SMc01030(pdhAa) SMc01031(pdhAb)
            CCR: CC1205 CC1726 CC1727
            BSU: BG10207(pdhA) BG10208(pdhB)
            BHA: BH0213 BH0214 BH2654(pdhB) BH2655(pdhA)
            SAU: SA0944(phdB)
            SAV: SAV1077(pdhA) SAV1078(phdB)
            LLA: L0033(pdhA) L0034(pdhB)
            MGE: MG273(pdhB) MG274(pdhA)
            MPN: F11_orf327(pdhB) F11_orf358a(pdhA)
            MPU: MYPU_7630(pdhB) MYPU_7640(pdhA)
            MTU: Rv2241(aceE) Rv2496c(pdhB) Rv2497c(pdhA)
            MTC: MT2301 MT2571 MT2572
            MLE: ML1651(aceE)
            CTR: CT245 CT246
            CMU: TC0516 TC0517
            CPN: CPn0304 CPn0305
            CPA: CP0453 CP0454
            CPJ: pdhA pdhB
            SYN: sll1721(pdhB) slr1934
            DRA: DR0029 DR0030 DR0257
            HAL: VNG1926G(pdhA1) VNG2217G(pdhA2) VNG2218G(pdhB)
            TAC: Ta1437 Ta1438
            TVO: TVG0105141 TVG0106097
            APE: APE1674 APE1677
            SSO: SSO1369(pdhA-1) SSO1370(pdhB-1) SSO1525(pdhA-2)
                 SSO1526(pdhB-2)
            SCE: YBR221C(PDB1) YER178W(PDA1)
            SPO: PDA1(pda1) PDB1(pdb1)
            ATH: At1g01090(T25K16.8) At1g24180(F3I6.11) At1g30120(T2H7.8)
                 At1g59900(F23H11.21) At2g34590(T31E10.7) At5g50850(K7B16.2)
            CEL: C04C3.3 T05H10.6
            DME: CG11876 CG7010 CG7010_1 CG7010_2 CG7024 CG8199
            MMU: 97532(Pdha1) 97533(Pdhal)
            HSA: 5160(PDHA1) 5161(PDHA2) 5162(PDHB)
DISEASE     MIM: 179060  Pyruvate dehydrogenase, E1 beta polypeptide
            MIM: 179061  Pyruvate dehydrogenase, E1-alpha polypeptide, testis
                         specific
            MIM: 312170  Pyruvate dehydrogenase, E1-alpha polypeptide-1
STRUCTURES  PDB: 2PDE  2PDD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.4.1
            ExPASy - ENZYME nomenclature database: 1.2.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.4.1
            BRENDA, the Enzyme Database: 1.2.4.1
            SCOP (Structural Classification of Proteins): 1.2.4.1
///
ENTRY       EC 1.2.4.2
NAME        Oxoglutarate dehydrogenase (lipoamide)
            Oxoglutarate decarboxylase
            alpha-Ketoglutaric dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a disulfide as acceptor
SYSNAME     2-Oxoglutarate:lipoamde 2-oxidoreductase(decarboxylating and
            acceptor-succinylating)
REACTION    2-Oxoglutarate + Lipoamide = S-Succinyldihydrolipoamide + CO2
SUBSTRATE   2-Oxoglutarate
            Lipoamide
PRODUCT     S-Succinyldihydrolipoamide
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     Requires thiamine diphosphate; component of the multienzyme
            2-oxoglutarate dehydrogenase complex.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
GENES       ECO: b0726(sucA)
            ECE: Z0880(sucA)
            ECS: ECs0751
            YPE: YPO1113(sucA)
            HIN: HI1662(sucA)
            PMU: PM0277(sucA)
            XFA: XF1550
            VCH: VC2087
            PAE: PA1585(sucA)
            BUC: BU302(sucA)
            NME: NMB0955
            NMA: NMA1149(sucA)
            RPR: RP180(sucA)
            RCO: RC0227(sucA)
            MLO: mll4301
            SME: SMc02482(sucA)
            CCR: CC0339
            BSU: BG10272(odhA)
            BHA: BH2206
            SAU: SA1245(odhA)
            SAV: SAV1398(odhA)
            MTU: Rv1248c(sucA)
            MTC: MT1286
            MLE: ML1095(odhA)
            CTR: CT054
            CMU: TC0324
            CPN: CPn0378
            CPA: CP0378
            CPJ: sucA
            DRA: DR0287
            SCE: YIL125W(KGD1)
            SPO: SPBC3H7.03C(spbc3h7.03c)
            CEL: T22B11.5 ZK836.2
            DME: CG11661 CG7934
            HSA: 4967(OGDH)
DISEASE     MIM: 203740  Oxoglutarate dehydrogenase (lipoamide)
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.4.2
            ExPASy - ENZYME nomenclature database: 1.2.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.4.2
            BRENDA, the Enzyme Database: 1.2.4.2
///
ENTRY       EC 1.2.4.3
NAME        Deleted entry
            2-Oxoisocaproate dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a disulfide as acceptor
COMMENT     Deleted entry. Now included with EC 1.2.4.4.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.4.3
            ExPASy - ENZYME nomenclature database: 1.2.4.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.4.3
///
ENTRY       EC 1.2.4.4
NAME        3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)
            Branched-chain alpha-keto acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With a disulfide as acceptor
SYSNAME     3-Methyl-2-oxobutanoate:lipoamide oxidoreductase(decarboxylating
            and acceptor-2-methylpropanoylating)
REACTION    3-Methyl-2-oxobutanoate + Lipoamide =
            S-(2-Methylpropanoyl)-dihydrolipoamide + CO2
SUBSTRATE   3-Methyl-2-oxobutanoate
            Lipoamide
            (S)-3-Methyl-2-oxopentanoate
            3-Methyl-2-oxopentanoate
            4-Methyl-2-oxopentanoate
PRODUCT     S-(2-Methylpropanoyl)-dihydrolipoamide
            CO2
            S-(2-Methylbutanoyl)-dihydrolipoamide
            S-(3-Methylbutanoyl)-dihydrolipoamide
COFACTOR    Thiamine diphosphate
COMMENT     Requires thiamine diphosphate; apparently a multienzyme
            complex. Also acts on (S)-3-methyl-2-oxopentanoate and
            4-methyl-2-oxopentanoate.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
GENES       PAE: PA2247(bkdA1) PA2248(bkdA2)
            MLO: mll3629 mll4472 mll4473
            SME: SMc03201(bkdAa) SMc03202(bkdAb)
            BSU: BG10306(bkdA2) BG10307(bkdA1)
            BHA: BH2762(bfmBAB) BH2763(bfmBAA)
            SAU: SA1347(bfmBAB) SA1348(bfmBAA)
            SAV: SAV1505(bfmBAB) SAV1506(bfmBAA)
            CTR: CT340
            CMU: TC0618
            CPN: CPn0033
            CPA: CP0743
            CPJ: pdhA_pdhB
            ATH: At1g21400(F24J8.4) At1g55510(T5A14.9) At3g13450(MRP15.9)
                 At5g09300(T5E8.100) At5g34780(T3J11.40)
            CEL: Y39E4A.3
            HSA: 5014(OVD1A) 593(BCKDHA) 594(BCKDHB)
DISEASE     MIM: 248600  Branched chain keto acid dehydrogenase E1, alpha
                         polypeptide
            MIM: 248611  Branched chain keto acid dehydrogenase E1, beta
                         polypeptide
STRUCTURES  PDB: 1DTW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.4.4
            ExPASy - ENZYME nomenclature database: 1.2.4.4
            WIT (What Is There) Metabolic Reconstruction: 1.2.4.4
            BRENDA, the Enzyme Database: 1.2.4.4
            SCOP (Structural Classification of Proteins): 1.2.4.4
///
ENTRY       EC 1.2.7.1
NAME        Pyruvate synthase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     Pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)
REACTION    Pyruvate + CoA + Oxidized ferredoxin = Acetyl-CoA + CO2 +
            Reduced ferredoxin
SUBSTRATE   Pyruvate
            CoA
            Oxidized ferredoxin
PRODUCT     Acetyl-CoA
            CO2
            Reduced ferredoxin
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b1378(ydbK)
            ECE: Z2332(ydbK)
            ECS: ECs2000
            VCH: VCA0530
            HPY: HP1108 HP1109 HP1110 HP1111
            HPJ: jhp1035 jhp1036 jhp1037 jhp1038
            CJE: Cj1476c
            LLA: L29321(nifJ)
            CAC: CAC2229 CAC2499
            TPA: TP0939
            SYN: sll0741(nifJ)
            AAE: aq_1167(forA2) aq_1168(forB2) aq_1169(forG2) aq_1195(forA1)
                 aq_1196(forB1) aq_1200(forG1)
            TMA: TM0015 TM0016 TM0017 TM0018
            MJA: MJ0266(porB) MJ0267(porA) MJ0268(porD) MJ0269(porG)
            MTH: MTH1738 MTH1739 MTH1740
            AFU: AF1699(porG) AF1700(porD) AF1701(porA) AF1702(porB)
                 AF2052(vorB) AF2053(vorA) AF2054(vorD) AF2055(vorG)
            TAC: Ta0626 Ta0627 Ta0628 Ta0629
            TVO: TVG0870514 TVG0870807 TVG0871982 TVG0872869
            PHO: PH0678 PH0679 PH0680 PH0681 PH0682 PH0684 PH0685
            PAB: PAB1470 PAB1471(VOR) PAB1472(VOR) PAB1473(VOR) PAB1474
                 PAB1475(POR) PAB1476(POR)
            SSO: SSO11071(porD-2) SSO1206(porB-1) SSO1207(porA-1)
                 SSO1208(porG-1) SSO2128(porD-like) SSO2129(porA-like)
                 SSO2130(porB-like) SSO2756(porB-2) SSO2757(porA-2)
                 SSO2758(porG-2) SSO7412(porD-1)
STRUCTURES  PDB: 1B0P  2PDA  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.7.1
            ExPASy - ENZYME nomenclature database: 1.2.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.7.1
            BRENDA, the Enzyme Database: 1.2.7.1
            SCOP (Structural Classification of Proteins): 1.2.7.1
///
ENTRY       EC 1.2.7.2
NAME        2-Oxobutyrate synthase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     2-Oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)
REACTION    2-Oxobutanoate + CoA + Oxidized ferredoxin = Propanoyl-CoA +
            CO2 + Reduced ferredoxin
SUBSTRATE   2-Oxobutanoate
            CoA
            Oxidized ferredoxin
PRODUCT     Propanoyl-CoA
            CO2
            Reduced ferredoxin
PATHWAY     PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.7.2
            ExPASy - ENZYME nomenclature database: 1.2.7.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.7.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.7.2
            BRENDA, the Enzyme Database: 1.2.7.2
///
ENTRY       EC 1.2.7.3
NAME        2-Oxoglutarate synthase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     2-Oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)
REACTION    2-Oxoglutarate + CoA + Oxidized ferredoxin = Succinyl-CoA +
            CO2 + Reduced ferredoxin
SUBSTRATE   2-Oxoglutarate
            CoA
            Oxidized ferredoxin
PRODUCT     Succinyl-CoA
            CO2
            Reduced ferredoxin
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       HPY: HP0588 HP0589 HP0590 HP0591
            HPJ: jhp0536 jhp0537 jhp0538 jhp0539
            CJE: Cj0535(oorD) Cj0536(oorA) Cj0537(oorB) Cj0538(oorC)
            BHA: BH2373 BH2374
            SAU: SA1131 SA1132
            SAV: SAV1276 SAV1277
            CAC: CAC2458 CAC2459
            MTU: Rv2454c Rv2455c
            MTC: MT2529 MT2530
            TMA: TM0405 TM0406 TM0878 TM1164 TM1165
            MJA: MJ0276(korA) MJ0536(korG) MJ0537(korB)
            MTH: MTH1032 MTH1033 MTH1034 MTH1035 MTH536 MTH537
            AFU: AF0468(korB) AF0469(korA) AF0470(korD) AF0471(korG)
                 AF0749(orA) AF0750(orB)
            HAL: VNG0473G(porB) VNG0474G(porA) VNG1125G(korB) VNG1128G(korA)
            TAC: Ta0259 Ta0260 Ta0772 Ta0773
            TVO: TVG0881751 TVG0882664 TVG1405258 TVG1406112
            PHO: PH1660 PH1661 PH1662 PH1663 PH1665 PH1666
            PAB: PAB0341(korD) PAB0344(korB-1) PAB0345(korG-1) PAB0346(korA-2)
                 PAB0347(korB-2) PAB0348(korG-2) PAB2359(korA-1)
            APE: APE1472 APE1473 APE2126 APE2128
            SSO: SSO2815 SSO2816
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.7.3
            ExPASy - ENZYME nomenclature database: 1.2.7.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.7.3
            BRENDA, the Enzyme Database: 1.2.7.3
///
ENTRY       EC 1.2.99.1
NAME        Transferred to EC 1.1.99.19
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
COMMENT     Transferred entry. Now EC 1.1.99.19 - Uracil dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.1
            ExPASy - ENZYME nomenclature database: 1.2.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.1
///
ENTRY       EC 1.2.99.2
NAME        Carbon monoxide dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
SYSNAME     Carbon-monoxide:(acceptor) oxidoreductase
REACTION    CO + H2O + Acceptor = CO2 + Reduced acceptor
SUBSTRATE   CO
            H2O
            Acceptor
            Methyl viologen
PRODUCT     CO2
            Reduced acceptor
COFACTOR    Nickel
            Zinc
            Iron
COMMENT     Contains nickel, zinc and non-heme iron. Methyl viologen can act
            as acceptor. The enzyme from Clostridium sp. also catalyses an
            exchange reaction of carbon between C-1 of acetyl-CoA and CO;
            involved in the synthesis of acetyl-CoA from CO2 and H2.
PATHWAY     PATH: MAP00680  Methane metabolism
GENES       SME: SMc03101 SMc03102 SMc03103
            MJA: MJ0112(cdhE) MJ0113(cdhD) MJ0152 MJ0153(cdhA) MJ0154(cdhB)
                 MJ0156(cdhC) MJ0264 MJ0265(cooF2) MJ0728(cooS)
            MTH: MTH1708 MTH1709 MTH1710 MTH1712 MTH1713
            AFU: AF0376(cdhE) AF0377(cdhD) AF0379(cdhC) AF0950(cooF)
                 AF1100(cdhA-1) AF1101(cdhB-1) AF1849(cooS) AF2397(cdhA-2)
                 AF2398(cdhB-2)
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
STRUCTURES  PDB: 1QJ2  1JJY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.2
            ExPASy - ENZYME nomenclature database: 1.2.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.99.2
            BRENDA, the Enzyme Database: 1.2.99.2
            SCOP (Structural Classification of Proteins): 1.2.99.2
///
ENTRY       EC 1.2.99.3
NAME        Aldehyde dehydrogenase (pyrroloquinoline-quinone)
            Aldehyde dehydrogenase (acceptor)
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
SYSNAME     Aldehyde:(pyrroloquinoline-quinone) oxidoreductase
REACTION    Aldehyde + Acceptor + H2O = Carboxylate + Reduced acceptor
SUBSTRATE   Aldehyde
            Acceptor
            Aromatic aldehyde
            H2O
            Glyoxylate
            Glyceraldehyde
            Phenazine methosulfate
PRODUCT     Carboxylate
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein. Wide specificity; acts on straight-chain
            aldehydes up to C10, aromatic aldehydes, glyoxylate and
            glyceraldehyde.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.3
            ExPASy - ENZYME nomenclature database: 1.2.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.3
            BRENDA, the Enzyme Database: 1.2.99.3
///
ENTRY       EC 1.2.99.4
NAME        Formaldehyde dismutase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
SYSNAME     Formaldehyde:formaldehyde oxidoreductase
REACTION    Formaldehyde + Formaldehyde = Formate + Methanol
SUBSTRATE   Formaldehyde
            Acetaldehyde
            Propanal
PRODUCT     Formate
            Methanol
COMMENT     Formaldehyde and acetaldehyde can act as donors; formaldehyde,
            acetaldehyde and propanal can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.4
            ExPASy - ENZYME nomenclature database: 1.2.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.4
            BRENDA, the Enzyme Database: 1.2.99.4
///
ENTRY       EC 1.2.99.5
NAME        Formylmethanofuran dehydrogenase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
SYSNAME     Formylmethanofuran:(acceptor) oxidoreductase
REACTION    Formylmethanofuran + H2O + Acceptor = CO2 + Methanofuran +
            Reduced acceptor
SUBSTRATE   Formylmethanofuran
            H2O
            Acceptor
            Methyl viologen
            N-Furfurylformamide
PRODUCT     CO2
            Methanofuran
            Reduced acceptor
COFACTOR    Molybdenum
            Pterin
COMMENT     A molybdoprotein containing a pterin cofactor.  Methyl viologen
            can act as acceptor.  Also oxidizes N-furfurylformamide.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       MJA: MJ0658 MJ1165(fwdE) MJ1166(fwdF) MJ1167(fwdG) MJ1168(fwdD)
                 MJ1169(fwdA) MJ1171(fwdC)
            MTH: MTH106 MTH1553 MTH1554 MTH1555 MTH1556 MTH1557 MTH1558
                 MTH1559 MTH192 MTH238 MTH926
            AFU: AF1644(fwdF) AF1649(fwdG) AF1650(fwdB-1) AF1651(fwdD-1)
                 AF1928(fwdD-2) AF1929(fwdB-2) AF1930(fwdA) AF1931(fwdC)
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.5
            ExPASy - ENZYME nomenclature database: 1.2.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.5
            UM-BBD (Biocatalysis/Biodegradation Database): 1.2.99.5
///
ENTRY       EC 1.2.99.6
NAME        Carboxylate reductase
CLASS       Oxidoreductases
            Acting on the aldehyde or oxo group of donors
            With other acceptors
SYSNAME     Aldehyde:(acceptor) oxidoreductase
REACTION    an Aldehyde + Acceptor + H2O = a Carboxylate + Reduced acceptor
SUBSTRATE   Aldehyde
            Acceptor
            H2O
            Methyl viologen
PRODUCT     Carboxylate
            Reduced acceptor
COFACTOR    Tungsten
COMMENT     A tungsten protein.  Methyl viologen can act as acceptor.  In the
            reverse direction, non-activated acids are reduced by reduced
            viologens to aldehydes, but not to the corresponding alcohols.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.2.99.6
            ExPASy - ENZYME nomenclature database: 1.2.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.2.99.6
///
ENTRY       EC 1.3.1.1
NAME        Dihydrouracil dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,6-Dihydrouracil:NAD+ oxidoreductase
REACTION    5,6-Dihydrouracil + NAD+ = Uracil + NADH
SUBSTRATE   5,6-Dihydrouracil
            NAD+
PRODUCT     Uracil
            NADH
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.1
            ExPASy - ENZYME nomenclature database: 1.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.1
            BRENDA, the Enzyme Database: 1.3.1.1
///
ENTRY       EC 1.3.1.2
NAME        Dihydropyrimidine dehydrogenase (NADP+)
            Dihydrothymine dehydrogenase
            Dihydrouracil dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,6-Dihydrouracil:NADP+ oxidoreductase
REACTION    5,6-Dihydrouracil + NADP+ = Uracil + NADPH
SUBSTRATE   5,6-Dihydrouracil
            NADP+
            Dihydrothymine
PRODUCT     Uracil
            NADPH
            Thymine
COMMENT     Also acts on dihydrothymine.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       CEL: C25F6.3
            HSA: 1806(DPYD)
DISEASE     MIM: 274270  Dihydropyrimidine dehydrogenase
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
STRUCTURES  PDB: 1H7X  1H7W  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.2
            ExPASy - ENZYME nomenclature database: 1.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.2
            BRENDA, the Enzyme Database: 1.3.1.2
            SCOP (Structural Classification of Proteins): 1.3.1.2
///
ENTRY       EC 1.3.1.3
NAME        Cortisone beta-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4,5beta-Dihydrocortisone:NADP+ delta4-oxidoreductase
REACTION    4,5beta-Dihydrocortisone + NADP+ = Cortisone + NADPH
SUBSTRATE   4,5beta-Dihydrocortisone
            NADP+
PRODUCT     Cortisone
            NADPH
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.3
            ExPASy - ENZYME nomenclature database: 1.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.3
            BRENDA, the Enzyme Database: 1.3.1.3
///
ENTRY       EC 1.3.1.4
NAME        Cortisone alpha-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4,5alpha-Dihydrocortisone:NADP+ delta4-oxidoreductase
REACTION    4,5alpha-Dihydrocortisone + NADP+ = Cortisone + NADPH
SUBSTRATE   4,5alpha-Dihydrocortisone
            NADP+
PRODUCT     Cortisone
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.4
            ExPASy - ENZYME nomenclature database: 1.3.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.4
            BRENDA, the Enzyme Database: 1.3.1.4
///
ENTRY       EC 1.3.1.5
NAME        Cucurbitacin delta23 reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     23,24-Dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase
REACTION    23,24-Dihydrocucurbitacin + NAD+ or NADP+ = Cucurbitacin +
            NADH or NADPH
SUBSTRATE   23,24-Dihydrocucurbitacin
            NAD+
            NADP+
PRODUCT     Cucurbitacin
            NADH
            NADPH
COFACTOR    Manganese
COMMENT     Requires Mn2+; Fe2+ or Zn2+ can replace Mn2+ to some extent.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.5
            ExPASy - ENZYME nomenclature database: 1.3.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.5
            BRENDA, the Enzyme Database: 1.3.1.5
///
ENTRY       EC 1.3.1.6
NAME        Fumarate reductase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Succinate:NAD+ oxidoreductase
REACTION    Succinate + NAD+ = Fumarate + NADH
SUBSTRATE   Succinate
            NAD+
PRODUCT     Fumarate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.6
            ExPASy - ENZYME nomenclature database: 1.3.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.6
            BRENDA, the Enzyme Database: 1.3.1.6
///
ENTRY       EC 1.3.1.7
NAME        meso-Tartrate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     meso-Tartrate:NAD+ oxidoreductase
REACTION    meso-Tartaric acid + NAD+ = Dihydroxyfumarate + NADH
SUBSTRATE   meso-Tartaric acid
            NAD+
PRODUCT     Dihydroxyfumarate
            NADH
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.7
            ExPASy - ENZYME nomenclature database: 1.3.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.7
            BRENDA, the Enzyme Database: 1.3.1.7
///
ENTRY       EC 1.3.1.8
NAME        Acyl-CoA dehydrogenase (NADP+)
            2-Enoyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-CoA:NADP+ 2-oxidoreductase
REACTION    Acyl-CoA + NADP+ = 2,3-Dehydroacyl-CoA + NADPH
SUBSTRATE   Acyl-CoA
            NADP+
PRODUCT     2,3-Dehydroacyl-CoA
            NADPH
COMMENT     The liver enzyme acts on enoyl-CoA derivatives of carbon chain
            length 4 to 16, with optimum activity on 2-hexenoyl-CoA.  In
            E. coli, cis-specific and trans-specific enzyme exist
            (EC 1.3.1.37-38).
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.8
            ExPASy - ENZYME nomenclature database: 1.3.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.8
            BRENDA, the Enzyme Database: 1.3.1.8
///
ENTRY       EC 1.3.1.9
NAME        Enoyl-[acyl-carrier protein] reductase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-[acyl-carrier-protein]:NAD+ oxidoreductase
REACTION    Acyl-[acyl-carrier protein] + NAD+ =
            trans-2,3-Dehydroacyl-[acyl-carrier protein] + NADH
SUBSTRATE   Acyl-[acyl-carrier protein]
            NAD+
            Enoyl-acyl-[acyl-carrier protein]
PRODUCT     trans-2,3-Dehydroacyl-[acyl-carrier protein]
            NADH
COMMENT     Catalyses the reduction of enoyl-acyl-[acyl-carrier protein]
            derivatives of carbon chain length from 4 to 16.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b1288(fabI)
            ECE: Z2512(fabI)
            ECS: ECs1861
            HIN: HI1734(fabI)
            PMU: PM0182(fabI)
            PAE: PA1806(fabI)
            BUC: BU265(fabI)
            NME: NMB0336
            NMA: NMA2152(fabI)
            HPY: HP0195(fabI)
            HPJ: jhp0181
            CJE: Cj1400c(fabI)
            RPR: RP365(fabI)
            RCO: RC0494(fabI)
            MLO: mll5565 mlr7458
            SME: SMc00005(fabI1) SMc00326(fabI2)
            CCR: CC3717
            BSU: BG13152(fabI)
            BHA: BH2843
            SAU: SA0869(fabI)
            SAV: SAV0996
            LLA: L161132(fabI)
            MTU: Rv1484(inhA)
            MTC: MT1531
            MLE: ML1806(inhA)
            CTR: CT104
            CMU: TC0380
            CPN: CPn0406
            CPA: CP0349
            CPJ: fabI
            SYN: slr1051(envM)
            DRA: DR1967
            AAE: aq_1552(fabI)
            SCE: YKL182W(FAS1)
            SPO: SPAC926.09C(spac926.09c)
STRUCTURES  PDB: 1QG6  1ENP  1ENO  1DFI  1DFH  1DFG  1D8A  1C14  1BVR  1D7O  
                 1CWU  1ZID  1QSG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.9
            ExPASy - ENZYME nomenclature database: 1.3.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.9
            BRENDA, the Enzyme Database: 1.3.1.9
            SCOP (Structural Classification of Proteins): 1.3.1.9
///
ENTRY       EC 1.3.1.10
NAME        Enoyl-[acyl-carrier protein] reductase (NADPH, B-specific)
            Acyl-ACP dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (B-specific)
REACTION    Acyl-[acyl-carrier protein] + NADP+ =
            trans-2,3-Dehydroacyl-[acyl-carrier protein] + NADPH
SUBSTRATE   Acyl-[acyl-carrier protein]
            NADP+
            Enoyl-acyl-[acyl-carrier protein]
PRODUCT     trans-2,3-Dehydroacyl-[acyl-carrier protein]
            NADPH
COMMENT     Catalyses the reduction of enoyl-acyl-[acyl-carrier-protein]
            derivatives of carbon chain length from 4 to 16.  The yeast and
            E. coli enzymes are B-specific with respect to NADP+
            (cf. EC 1.3.1.19).
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.10
            ExPASy - ENZYME nomenclature database: 1.3.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.10
            BRENDA, the Enzyme Database: 1.3.1.10
///
ENTRY       EC 1.3.1.11
NAME        Coumarate reductase
            Melilotate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-(2-Hydroxyphenyl)propanoate:NAD+ oxidoreductase
REACTION    3-(2-Hydroxyphenyl)propanoate + NAD+ = 2-Coumarate + NADH
SUBSTRATE   3-(2-Hydroxyphenyl)propanoate
            NAD+
PRODUCT     2-Coumarate
            NADH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.11
            ExPASy - ENZYME nomenclature database: 1.3.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.11
            BRENDA, the Enzyme Database: 1.3.1.11
///
ENTRY       EC 1.3.1.12
NAME        Prephenate dehydrogenase
            Hydroxyphenylpyruvate synthase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Prephenate:NAD+ oxidoreductase(decarboxylating)
REACTION    Prephenate + NAD+ = 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADH
SUBSTRATE   Prephenate
            NAD+
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            CO2
            NADH
COMMENT     This enzyme in the enteric bacteria also possesses chorismate
            mutase activity (EC 5.4.99.5) and converts chorismate into
            prephenate.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2600(tyrA)
            ECE: Z3892(tyrA)
            ECS: ECs3463
            YPE: YPO3285(tyrA)
            HIN: HI1290(tyrA)
            PMU: PM0664(tyrA)
            XFA: XF2338
            VCH: VC0696
            PAE: PA3164
            NME: NMB0440
            NMA: NMA2045
            HPY: HP1380(tyrA)
            HPJ: jhp1294
            CJE: Cj0130(tyrA)
            MLO: mll3535
            SME: SMc00711(tyrC)
            CCR: CC2224
            BSU: BG10293(tyrA)
            BHA: BH1666(tyrA)
            SAU: SA1197(tyrA)
            SAV: SAV1350(tyrA)
            LLA: L0058(tyrA)
            SPN: SP1373
            SPR: spr1231(tyrA)
            CAC: CAC0893
            MTU: Rv3754(tyrA)
            MTC: MT3861
            MLE: ML2472
            SYN: slr2081(tyrA)
            DRA: DR1122
            AAE: aq_1755(tyrA)
            TMA: TM0344
            MJA: MJ0612
            MTH: MTH1640
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.12
            ExPASy - ENZYME nomenclature database: 1.3.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.12
            BRENDA, the Enzyme Database: 1.3.1.12
///
ENTRY       EC 1.3.1.13
NAME        Prephenate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Prephenate:NADP+ oxidoreductase(decarboxylating)
REACTION    Prephenate + NADP+ = 3-(4-Hydroxyphenyl)pyruvate + CO2 + NADPH
SUBSTRATE   Prephenate
            NADP+
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            CO2
            NADPH
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       SCE: YBR166C(TYR1)
            SPO: SPCC1494.04C(spcc1494.04c)
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.13
            ExPASy - ENZYME nomenclature database: 1.3.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.13
            BRENDA, the Enzyme Database: 1.3.1.13
///
ENTRY       EC 1.3.1.14
NAME        Orotate reductase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Dihydroorotate:NAD+ oxidoreductase
REACTION    (S)-Dihydroorotate + NAD+ = Orotate + NADH
SUBSTRATE   (S)-Dihydroorotate
            NAD+
PRODUCT     Orotate
            NADH
COFACTOR    FAD
            FMN
COMMENT     A flavoprotein (FAD, FMN).
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.14
            ExPASy - ENZYME nomenclature database: 1.3.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.14
            BRENDA, the Enzyme Database: 1.3.1.14
///
ENTRY       EC 1.3.1.15
NAME        Orotate reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (S)-Dihydroorotate:NADP+ oxidoreductase
REACTION    (S)-Dihydroorotate + NADP+ = Orotate + NADPH
SUBSTRATE   (S)-Dihydroorotate
            NADP+
PRODUCT     Orotate
            NADPH
COFACTOR    FAD
COMMENT     A flavoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.15
            ExPASy - ENZYME nomenclature database: 1.3.1.15
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.15
            BRENDA, the Enzyme Database: 1.3.1.15
///
ENTRY       EC 1.3.1.16
NAME        beta-Nitroacrylate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Nitropropanoate:NADP+ oxidoreductase
REACTION    3-Nitropropanoate + NADP+ = 3-Nitroacrylate + NADPH
SUBSTRATE   3-Nitropropanoate
            NADP+
PRODUCT     3-Nitroacrylate
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.16
            ExPASy - ENZYME nomenclature database: 1.3.1.16
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.16
            BRENDA, the Enzyme Database: 1.3.1.16
///
ENTRY       EC 1.3.1.17
NAME        3-Methyleneoxindole reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Methyloxindole:NADP+ oxidoreductase
REACTION    3-Methyloxindole + NADP+ = 3-Methyleneoxindole + NADPH
SUBSTRATE   3-Methyloxindole
            NADP+
PRODUCT     3-Methyleneoxindole
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.17
            ExPASy - ENZYME nomenclature database: 1.3.1.17
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.17
            BRENDA, the Enzyme Database: 1.3.1.17
///
ENTRY       EC 1.3.1.18
NAME        Kynurenate-7,8-dihydrodiol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     7,8-Dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase
REACTION    7,8-Dihydro-7,8-dihydroxykynurenate + NAD+ =
            7,8-Dihydroxykynurenate + NADH
SUBSTRATE   7,8-Dihydro-7,8-dihydroxykynurenate
            NAD+
PRODUCT     7,8-Dihydroxykynurenate
            NADH
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.18
            ExPASy - ENZYME nomenclature database: 1.3.1.18
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.18
            BRENDA, the Enzyme Database: 1.3.1.18
///
ENTRY       EC 1.3.1.19
NAME        cis-1,2-Dihydrobenzene-1,2-diol dehydrogenase
            cis-Benzene glycol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-1,2-Dihydrobenzene-1,2-diol:NAD+ oxidoreductase
REACTION    cis-1,2-Dihydrobenzene-1,2-diol + NAD+ = Catechol + NADH
SUBSTRATE   cis-1,2-Dihydrobenzene-1,2-diol
            NAD+
PRODUCT     Catechol
            NADH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00643  Styrene degradation
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.19
            ExPASy - ENZYME nomenclature database: 1.3.1.19
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.19
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.19
            BRENDA, the Enzyme Database: 1.3.1.19
///
ENTRY       EC 1.3.1.20
NAME        trans-1,2-Dihydrobenzene-1,2-diol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     trans-1,2-Dihydrobenzene-1,2-diol:NADP+ oxidoreductase
REACTION    trans-1,2-Dihydrobenzene-1,2-diol + NADP+ = Catechol + NADPH
SUBSTRATE   trans-1,2-Dihydrobenzene-1,2-diol
            NADP+
PRODUCT     Catechol
            NADPH
GENES       HSA: 1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 27294(HUM2DD)
                 8644(AKR1C3)
DISEASE     MIM: 600451  Aldo-keto reductase family 1, member C4 (chlordecone
                         reductase)
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.20
            ExPASy - ENZYME nomenclature database: 1.3.1.20
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.20
            BRENDA, the Enzyme Database: 1.3.1.20
///
ENTRY       EC 1.3.1.21
NAME        7-Dehydrocholesterol reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Cholesterol:NADP+ delta7-oxidoreductase
REACTION    Cholesterol + NADP+ = Cholesta-5,7-dien-3beta-ol + NADPH
SUBSTRATE   Cholesterol
            NADP+
PRODUCT     Cholesta-5,7-dien-3beta-ol
            NADPH
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.21
            ExPASy - ENZYME nomenclature database: 1.3.1.21
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.21
            BRENDA, the Enzyme Database: 1.3.1.21
///
ENTRY       EC 1.3.1.22
NAME        Cholestenone 5alpha-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Oxo-5alpha-steroid:NADP+ delta4-oxidoreductase
REACTION    5alpha-Cholestan-3-one + NADP+ = Cholest-4-en-3-one + NADPH
SUBSTRATE   5alpha-Cholestan-3-one
            NADP+
PRODUCT     Cholest-4-en-3-one
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.22
            ExPASy - ENZYME nomenclature database: 1.3.1.22
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.22
            BRENDA, the Enzyme Database: 1.3.1.22
///
ENTRY       EC 1.3.1.23
NAME        Cholestenone 5beta-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Oxo-5beta-steroid:NADP+ delta4-oxidoreductase
REACTION    5beta-Cholestan-3-one + NADP+ = Cholest-4-en-3-one + NADPH
SUBSTRATE   5beta-Cholestan-3-one
            NADP+
PRODUCT     Cholest-4-en-3-one
            NADPH
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00140  C21-Steroid hormone metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.23
            ExPASy - ENZYME nomenclature database: 1.3.1.23
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.23
            BRENDA, the Enzyme Database: 1.3.1.23
///
ENTRY       EC 1.3.1.24
NAME        Biliverdin reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Bilirubin:NAD(P)+ oxidoreductase
REACTION    Bilirubin + NAD+ or NADP+ = Biliverdin + NADH or NADPH
SUBSTRATE   Bilirubin
            NAD+
            NADP+
PRODUCT     Biliverdin
            NADH
            NADPH
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       SYN: slr1784(bvdR)
            HSA: 644(BLVRA) 645(BLVRB)
DISEASE     MIM: 109750  Biliverdin reductase A
            MIM: 600941  Biliverdin reductase B
STRUCTURES  PDB: 1HE3  1HE5  1GCU  1HDO  1HE2  1HE4  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.24
            ExPASy - ENZYME nomenclature database: 1.3.1.24
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.24
            BRENDA, the Enzyme Database: 1.3.1.24
            SCOP (Structural Classification of Proteins): 1.3.1.24
///
ENTRY       EC 1.3.1.25
NAME        1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+
            $ oxidoreductase (decarboxylating)
REACTION    1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ =
            Catechol + CO2 + NADH
SUBSTRATE   1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
            NAD+
PRODUCT     Catechol
            CO2
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.25
            ExPASy - ENZYME nomenclature database: 1.3.1.25
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.25
            BRENDA, the Enzyme Database: 1.3.1.25
///
ENTRY       EC 1.3.1.26
NAME        Dihydrodipicolinate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,3,4,5-Tetrahydrodipicolinate:NAD(P)+ oxidoreductase
REACTION    2,3,4,5-Tetrahydrodipicolinate + NAD+ or NADP+ =
            2,3-Dihydrodipicolinate + NADH or NADPH
SUBSTRATE   2,3,4,5-Tetrahydrodipicolinate
            NADP+
            NAD+
PRODUCT     2,3-Dihydrodipicolinate
            NADH
            NADPH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b0031(dapB)
            ECE: Z0036(dapB)
            ECS: ECs0034
            YPE: YPO0480(dapB)
            HIN: HI1308(dapB)
            PMU: PM0726(dapB)
            XFA: XF1105
            VCH: VC2391
            PAE: PA4759(dapB)
            BUC: BU146(dapB)
            NME: NMB0203
            NMA: NMA0066(dapB)
            HPY: HP0510(dapB)
            HPJ: jhp0460
            CJE: Cj0197c(dapB)
            RPR: RP148(dapB)
            RCO: RC0190(dapB)
            MLO: mlr4642 mlr7948
            SME: SMc02837(dapB)
            CCR: CC3550
            BSU: BG11207(dapB)
            BHA: BH1680(dapB)
            SAU: SA1228(dapB)
            SAV: SAV1381(dapB)
            LLA: L0094(dapB)
            SPN: SP1555
            SPR: spr1414(dapB)
            CAC: CAC2379(dapB)
            MTU: Rv2773c(dapB)
            MTC: MT2843
            CTR: CT364
            CMU: TC0643
            CPN: CPn1047
            CPA: CP0805
            CPJ: dapB
            SYN: sll1058(dapB)
            AAE: aq_916(dapB)
            TMA: TM1520
            MJA: MJ0422(dapB)
            MTH: MTH800
            AFU: AF0909(dapB)
MOTIF       PS: PS01298  [ER]-[IV]-x-E-x-H-x(3)-K-x-D-x(2)-S-G-[TA]-A
STRUCTURES  PDB: 1DRV  1ARZ  1DIH  1DRU  1DRW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.26
            ExPASy - ENZYME nomenclature database: 1.3.1.26
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.26
            BRENDA, the Enzyme Database: 1.3.1.26
            SCOP (Structural Classification of Proteins): 1.3.1.26
///
ENTRY       EC 1.3.1.27
NAME        2-Hexadecenal reductase
            2-Alkenal reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hexadecanal:NADP+ delta2-oxidoreductase
REACTION    Hexadecanal + NADP+ = 2-trans-Hexadecenal + NADPH
SUBSTRATE   Hexadecanal
            NADP+
PRODUCT     2-trans-Hexadecenal
            NADPH
COMMENT     Specific for long chain 2-trans- and 2-cis-alkenals, with chain
            length optimum around 14 to 16 carbon atoms.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.27
            ExPASy - ENZYME nomenclature database: 1.3.1.27
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.27
            BRENDA, the Enzyme Database: 1.3.1.27
///
ENTRY       EC 1.3.1.28
NAME        2,3-Dihydro-2,3-dihydroxybenzoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,3-Dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase
REACTION    2,3-Dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-Dihydroxybenzoate
            + NADH
SUBSTRATE   2,3-Dihydro-2,3-dihydroxybenzoate
            NAD+
PRODUCT     2,3-Dihydroxybenzoate
            NADH
COMMENT     Formerly EC 1.1.1.109.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b0596(entA)
            ECE: Z0738(entA)
            ECS: ECs0635
            VCH: VC0774
            BSU: BG11019(dhbA)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.28
            ExPASy - ENZYME nomenclature database: 1.3.1.28
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.28
            BRENDA, the Enzyme Database: 1.3.1.28
///
ENTRY       EC 1.3.1.29
NAME        cis-1,2-Dihydro-1,2-dihydroxynaphthalene dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-1,2-Dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase
REACTION    cis-1,2-Dihydronaphthalene-1,2-diol + NAD+ =
            Naphthalene-1,2-diol + NADH
SUBSTRATE   cis-1,2-Dihydronaphthalene-1,2-diol
            NAD+
PRODUCT     Naphthalene-1,2-diol
            NADH
COMMENT     Also acts, at half the rate, on cis-anthracene dihydrodiol and
            cis-phenanthrene dihydrodiol.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00626  Nitorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.29
            ExPASy - ENZYME nomenclature database: 1.3.1.29
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.29
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.29
            BRENDA, the Enzyme Database: 1.3.1.29
///
ENTRY       EC 1.3.1.30
NAME        Progesterone 5alpha-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5alpha-Pregnane-3,20-dione:NADP+ 5-oxidoreductase
REACTION    5alpha-Pregnane-3,20-dione + NADP+ = Progesterone + NADPH
SUBSTRATE   5alpha-Pregnane-3,20-dione
            NADP+
PRODUCT     Progesterone
            NADPH
            Testosterone
            20alpha-Hydroxy-4-pregnen-3-one
COMMENT     Testosterone and 20alpha-hydroxy-4-pregnen-3-one can act in
            place of progesterone.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.30
            ExPASy - ENZYME nomenclature database: 1.3.1.30
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.30
            BRENDA, the Enzyme Database: 1.3.1.30
///
ENTRY       EC 1.3.1.31
NAME        2-Enoate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Butanoate:NAD+ delta2-oxidoreductase
REACTION    Butanoate + NAD+ = 2-Butenoate + NADH
SUBSTRATE   Butanoate
            NAD+
PRODUCT     2-Butenoate
            NADH
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     An iron-sulfur-flavoprotein (FAD). Acts (in the reverse direction)
            on a wide range of alkyl and aryl alpha,beta-unsaturated
            carboxylate ions; 2-butenoate was the best substrate tested.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.31
            ExPASy - ENZYME nomenclature database: 1.3.1.31
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.31
            BRENDA, the Enzyme Database: 1.3.1.31
///
ENTRY       EC 1.3.1.32
NAME        Maleylacetate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     3-Oxoadipate:NAD(P)+ oxidoreductase
REACTION    3-Oxoadipate + NAD+ or NADP+ = 2-Maleylacetate + NADH or NADPH
SUBSTRATE   3-Oxoadipate
            NAD+
            NADP+
PRODUCT     2-Maleylacetate
            NADH
            NADPH
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00627  1,4-Dichlorobenzene degradation
GENES       SSO: SSO2490(clcE)
MOTIF       PS: PS00060  [GSW]-x-[LIVTSACD]-[GH]-x(2)-[GSAE]-[GSHYQ]-x-[LIVTP]-
                         [GAST]-[GAS]-x(3)-[LIVMT]-x-[HNS]-[GA]-x-[GTAC]
            PS: PS00913  [STALIV]-[LIVF]-x-[DE]-x(6,7)-P-x(4)-[ALIV]-x-[GST]-
                         x(2)-D-[TAIVM]-[LIVMF]-x(4)-E
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.32
            ExPASy - ENZYME nomenclature database: 1.3.1.32
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.32
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.32
            BRENDA, the Enzyme Database: 1.3.1.32
///
ENTRY       EC 1.3.1.33
NAME        Protochlorophyllide reductase
            NADPH--protochlorophyllide oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Chlorophyllide-a:NADP+ 7,8-oxidoreductase
REACTION    Chlorophyllide a + NADP+ = Protochlorophyllide + NADPH
SUBSTRATE   Chlorophyllide a
            NADP+
PRODUCT     Protochlorophyllide
            NADPH
COMMENT     The enzyme catalyses a light-dependent trans-reduction of the
            D-ring of protochlorophyllide; the product has the
            (7S,8S)-configuration.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       SYN: slr0506(pcr) slr0750(chlN) slr0772(chlB)
            ATH: At1g03630(F21B7.35) At4g27440(F27G19.40)
MOTIF       PS: PS00692  D-x-L-G-D-V-V-C-G-G-F-[AGSP]-x-P
            PS: PS00746  E-x-G-G-P-x(2)-[GA]-x-G-C-[AG]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.33
            ExPASy - ENZYME nomenclature database: 1.3.1.33
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.33
            BRENDA, the Enzyme Database: 1.3.1.33
///
ENTRY       EC 1.3.1.34
NAME        2,4-Dienoyl-CoA reductase (NADPH)
            4-Enoyl-CoA reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     trans-2,3-Didehydroacyl-CoA:NADP+ 4-oxidoreductase
REACTION    trans-2,3-Didehydroacyl-CoA + NADP+ =
            trans,trans-2,3,4,5-Tetradehydroacyl-CoA + NADPH
SUBSTRATE   trans-2,3-Didehydroacyl-CoA
            NADP+
PRODUCT     trans,trans-2,3,4,5-Tetradehydroacyl-CoA
            NADPH
COMMENT     Best substrates for reduction contain a 2,4-diene structure with
            chain-length 8 or 10.
GENES       ECO: b3081(fadH)
            ECE: Z4434(fadH)
            ECS: ECs3963
            YPE: YPO0589(fadH)
            VCH: VC1993
            PAE: PA3092(fadH1) PA4814(fadH2)
            MTU: Rv1175c(fadH)
            MTC: MT1212
            HSA: 1666(DECR1)
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.34
            ExPASy - ENZYME nomenclature database: 1.3.1.34
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.34
            BRENDA, the Enzyme Database: 1.3.1.34
///
ENTRY       EC 1.3.1.35
NAME        Phosphatidylcholine desaturase
            Oleate desaturase
            Linoleate synthase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+
            $ delta12-oxidoreductase
REACTION    1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+ =
            1-Acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH
SUBSTRATE   1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine
            NAD+
PRODUCT     1-Acyl-2-linoleoyl-sn-glycero-3-phosphocholine
            NADH
COMMENT     Also desaturates phosphatidylcholine containing the oleoyl group
            on O-2 of the glycerol residue.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.35
            ExPASy - ENZYME nomenclature database: 1.3.1.35
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.35
            BRENDA, the Enzyme Database: 1.3.1.35
///
ENTRY       EC 1.3.1.36
NAME        Geissoschizine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Geissoschizine:NADP+ 4,21-oxidoreductase
REACTION    Geissoschizine + NADP+ = 4,21-Dehydrogeissoschizine + NADPH
SUBSTRATE   Geissoschizine
            NADP+
PRODUCT     4,21-Dehydrogeissoschizine
            NADPH
COMMENT     Involved in the interconversion of heteroyohimbine alkaloids in
            Catharanthus roseus.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.36
            ExPASy - ENZYME nomenclature database: 1.3.1.36
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.36
            BRENDA, the Enzyme Database: 1.3.1.36
///
ENTRY       EC 1.3.1.37
NAME        cis-2-Enoyl-CoA reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-CoA:NADP+ cis-2-oxidoreductase
REACTION    Acyl-CoA + NADP+ = cis-2,3-Dehydroacyl-CoA + NADPH
SUBSTRATE   Acyl-CoA
            NADP+
PRODUCT     cis-2,3-Dehydroacyl-CoA
            NADPH
COMMENT     Not identical with EC 1.3.1.38 (cf. EC 1.3.1.8).
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.37
            ExPASy - ENZYME nomenclature database: 1.3.1.37
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.37
            BRENDA, the Enzyme Database: 1.3.1.37
///
ENTRY       EC 1.3.1.38
NAME        trans-2-Enoyl-CoA reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-CoA:NADP+ trans-2-oxidoreductase
REACTION    Acyl-CoA + NADP+ = trans-2,3-Dehydroacyl-CoA + NADPH
SUBSTRATE   Acyl-CoA
            NADP+
PRODUCT     trans-2,3-Dehydroacyl-CoA
            NADPH
COMMENT     Not identical with EC 1.3.1.37 (cf. EC 1.3.1.8).
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.38
            ExPASy - ENZYME nomenclature database: 1.3.1.38
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.38
            BRENDA, the Enzyme Database: 1.3.1.38
///
ENTRY       EC 1.3.1.39
NAME        Enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific)
            Acyl-ACP dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-[acyl-carrier-protein]:NADP+ oxidoreductase (A-specific)
REACTION    Acyl-[acyl-carrier protein] + NADP+ =
            trans-2,3-Dehydroacyl-[acyl-carrier protein] + NADPH
SUBSTRATE   Acyl-[acyl-carrier protein]
            NADP+
PRODUCT     trans-2,3-Dehydroacyl-[acyl-carrier protein]
            NADPH
COMMENT     The liver enzyme is A-specific with respect to NADP+
            (cf. EC 1.3.1.10).
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.39
            ExPASy - ENZYME nomenclature database: 1.3.1.39
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.39
            BRENDA, the Enzyme Database: 1.3.1.39
///
ENTRY       EC 1.3.1.40
NAME        2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,6-Dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase
REACTION    2,6-Dioxo-6-phenylhexanoate + NADP+ =
            2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH
SUBSTRATE   2,6-Dioxo-6-phenylhexanoate
            NADP+
PRODUCT     2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
            NADPH
COMMENT     Broad specificity; reduces a number of compounds produced by
            Pseudomonas from aromatic hydrocarbons by ring fission.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.40
            ExPASy - ENZYME nomenclature database: 1.3.1.40
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.40
            BRENDA, the Enzyme Database: 1.3.1.40
///
ENTRY       EC 1.3.1.41
NAME        Xanthommatin reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,12-Dihydroxanthommatin:NAD+ oxidoreductase
REACTION    5,12-Dihydroxanthommatin + NAD+ = Xanthommatin + NADH
SUBSTRATE   5,12-Dihydroxanthommatin
            NAD+
PRODUCT     Xanthommatin
            NADH
COMMENT     From Drosophila melanogaster.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.41
            ExPASy - ENZYME nomenclature database: 1.3.1.41
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.41
            BRENDA, the Enzyme Database: 1.3.1.41
///
ENTRY       EC 1.3.1.42
NAME        12-Oxophytodienoate reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+
            $ 4-oxidoreductase
REACTION    8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate +
            NADP+ = (15Z)-12-Oxophyto-10,15-dienoate + NADPH
SUBSTRATE   8-[(1R,2R)-3-Oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate
            NADP+
PRODUCT     (15Z)-12-Oxophyto-10,15-dienoate
            NADPH
COMMENT     Involved in the conversion of linolenate into jasmonate in Zea
            mays.
STRUCTURES  PDB: 1ICP  1ICQ  1ICS  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.42
            ExPASy - ENZYME nomenclature database: 1.3.1.42
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.42
            BRENDA, the Enzyme Database: 1.3.1.42
///
ENTRY       EC 1.3.1.43
NAME        Cyclohexadienyl dehydrogenase
            Arogenate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Arogenate:NAD+ oxidoreductase
REACTION    L-Arogenate + NAD+ = L-Tyrosine + NADH + CO2
SUBSTRATE   L-Arogenate
            NAD+
            Prephenate
            D-Prephenyllactate
PRODUCT     L-Tyrosine
            NADH
            CO2
COMMENT     Also acts on prephenate and D-prephenyllactate. cf. EC 1.3.1.12.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       SME: SMc00711(tyrC)
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.43
            ExPASy - ENZYME nomenclature database: 1.3.1.43
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.43
            BRENDA, the Enzyme Database: 1.3.1.43
///
ENTRY       EC 1.3.1.44
NAME        trans-2-Enoyl-CoA reductase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Acyl-CoA:NAD+ trans-2-oxidoreductase
REACTION    Acyl-CoA + NAD+ = trans-2,3-Didehydroacyl-CoA + NADH
SUBSTRATE   Acyl-CoA
            NAD+
PRODUCT     trans-2,3-Didehydroacyl-CoA
            NADH
COMMENT     The enzyme from Euglena gracilis acts on crotonoyl-CoA and, more
            slowly, on trans-hex-2-enoyl-CoA and trans-oct-2-enoyl-CoA.
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.44
            ExPASy - ENZYME nomenclature database: 1.3.1.44
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.44
            BRENDA, the Enzyme Database: 1.3.1.44
///
ENTRY       EC 1.3.1.45
NAME        2'-hydroxyisoflavone reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Vestitone:NADP+ oxidoreductase
REACTION    Vestitone + NADP+ = 2'-Hydroxyformononetin + NADPH
SUBSTRATE   Vestitone
            NADP+
            Isoflavanone
PRODUCT     2'-Hydroformononetin
            NADPH
            2'-Hydroxyisoflavone
            2'-hydroxypseudobaptigenin
COMMENT     In the reverse reaction, a 2'-hydroxyisoflavone is reduced to an
            isoflavanone; 2'-hydroxypseudobaptigenin also acts.  Involved in
            the biosysthesis of the pterocarpin phytoalexins medicarpin and
            maachiain.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.45
            ExPASy - ENZYME nomenclature database: 1.3.1.45
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.45
            BRENDA, the Enzyme Database: 1.3.1.45
///
ENTRY       EC 1.3.1.46
NAME        Biochanin-A reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Dihydrobiochanin-A:NADP+ delta2-oxidoreductase
REACTION    Dihydrobiochanin A + NADP+ = Biochanin A + NADPH
SUBSTRATE   Dihydrobiochanin A
            NADP+
PRODUCT     Biochanin A
            NADPH
COMMENT     Some other isoflavones are reduced to the corresponding
            isoflavanones.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.46
            ExPASy - ENZYME nomenclature database: 1.3.1.46
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.46
            BRENDA, the Enzyme Database: 1.3.1.46
///
ENTRY       EC 1.3.1.47
NAME        alpha-Santonin 1,2-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1,2-Dihydrosantonin:NAD(P)+ 1,2-oxidoreductase
REACTION    1,2-Dihydrosantonin + NAD+ or NADP+ = alpha-Santonin + NADH or NADPH
SUBSTRATE   1,2-Dihydrosantonin
            NAD+
            NADP+
PRODUCT     alpha-Santonin
            NADH
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.47
            ExPASy - ENZYME nomenclature database: 1.3.1.47
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.47
            BRENDA, the Enzyme Database: 1.3.1.47
///
ENTRY       EC 1.3.1.48
NAME        15-Oxoprostaglandin 13-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+
            $ delta13-oxidoreductase
REACTION    (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate + NAD+ or NADP+ =
            (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprosta-13-enoate +
            NADH or NADPH
SUBSTRATE   (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate
            NAD+
            NADP+
PRODUCT     (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprosta-13-enoate
            NADH
            NADPH
COMMENT     Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives.  The
            enzyme from placenta is specific for NAD+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.48
            ExPASy - ENZYME nomenclature database: 1.3.1.48
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.48
            BRENDA, the Enzyme Database: 1.3.1.48
///
ENTRY       EC 1.3.1.49
NAME        cis-3,4-Dihydrophenanthrene-3,4-diol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+)-cis-3,4-Dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase
REACTION    (+)-cis-3,4-Dihydrophenanthrene-3,4-diol + NAD+ =
            Phenanthrene-3,4-diol + NADH
SUBSTRATE   (+)-cis-3,4-Dihydrophenanthrene-3,4-diol
            NAD+
PRODUCT     Phenanthrene-3,4-diol
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.49
            ExPASy - ENZYME nomenclature database: 1.3.1.49
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.49
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.49
///
ENTRY       EC 1.3.1.50
NAME        Transferred to EC 1.1.1.252
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.1.1.252 - Tetrahydroxynaphthalene
            reductase.
STRUCTURES  PDB: 1YBV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.50
            ExPASy - ENZYME nomenclature database: 1.3.1.50
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.50
            SCOP (Structural Classification of Proteins): 1.3.1.50
///
ENTRY       EC 1.3.1.51
NAME        2'-Hydroxydaidzein reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2'-Hydroxydihydrodaidzein:NADP+ 2-oxidoreductase
REACTION    2'-Hydroxydihydrodaidzein + NADP+ = 2'-Hydroxydaidzein + NADPH
SUBSTRATE   2'-Hydroxydihydrodaidzein
            NADP+
PRODUCT     2'-Hydroxydaidzein
            NADPH
COMMENT     The enzyme is specific to the reduction of
            2'-hydroxy-5-deoxyisoflavones.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.51
            ExPASy - ENZYME nomenclature database: 1.3.1.51
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.51
///
ENTRY       EC 1.3.1.52
NAME        2-Methyl-branched-chain-enoyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2-Methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase
REACTION    2-Methylbutanoyl-CoA + NAD+ = 2-Methylcrotanoyl-CoA + NADH
SUBSTRATE   2-Methylbutanoyl-CoA
            NAD+
PRODUCT     2-Methylcrotanoyl-CoA
            NADH
COFACTOR    FAD
COMMENT     A flavoprotein (FAD) from Ascaris suum.  The reaction proceeds
            only in the presence of another flavoprotein
            ('electron-transferring flavoprotein').
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.52
            ExPASy - ENZYME nomenclature database: 1.3.1.52
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.52
///
ENTRY       EC 1.3.1.53
NAME        (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate
            $ dehydrogenase
            (1R,2S)-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate
            $ dehydrogenase
            Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ =
            3,4-Dihydroxybenzoate + CO2 + NADH
SUBSTRATE   (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate
            NAD+
PRODUCT     3,4-Dihydroxybenzoate
            CO2
            NADH
COFACTOR    Iron
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.53
            ExPASy - ENZYME nomenclature database: 1.3.1.53
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.53
///
ENTRY       EC 1.3.1.54
NAME        Precorrin-6X reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    Precorrin 6Y + NADP+ = Precorrin 6X + NADPH
SUBSTRATE   Precorrin 6Y
            NADP+
PRODUCT     Precorrin 6X
            NADPH
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       PAE: PA2909
            MLO: mll1382
            SME: SMc03189(cobK)
            CAC: CAC1381(cbiJ/cobK)
            MTU: Rv2070c(cobK)
            MTC: MT2130
            SYN: slr0252
            MJA: MJ0552
            MTH: MTH1002
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.54
            ExPASy - ENZYME nomenclature database: 1.3.1.54
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.54
///
ENTRY       EC 1.3.1.55
NAME        cis-1,2-Dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase
            cis-1,2-Dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase
            2-Hydro-1,2-dihydroxybenzoate dehydrogenase
            DHB dehydrogenase.
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    cis-1,2-Dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ =
            Catechol + NADH
SUBSTRATE   cis-1,2-Dihydroxycyclohexa-3,5-diene-1-carboxylate
            NAD+
PRODUCT     Catechol
            NADH
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.55
            ExPASy - ENZYME nomenclature database: 1.3.1.55
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.55
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.55
///
ENTRY       EC 1.3.1.56
NAME        cis-2,3-Dihydrobiphenyl-2,3-diol dehydrogenase
            2,3-Dihydro-2,3-dihydroxybiphenyl dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-3-Phenylcyclohexa-3,5-diene-1,2-diol:NAD oxidoreductase
REACTION    cis-3-Phenylcyclohexa-3,5-diene-1,2-diol + NAD = Biphenyl-2,3-diol
            + NADH
SUBSTRATE   cis-3-Phenylcyclohexa-3,5-diene-1,2-diol
            NAD
PRODUCT     Biphenyl-2,3-diol
            NADH
COMMENT     Catalyses the second step in the biphenyl degradation pathway in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.56
            ExPASy - ENZYME nomenclature database: 1.3.1.56
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.56
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.56
///
ENTRY       EC 1.3.1.57
NAME        Phloroglucinol reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Dihydrophloroglucinol:NADP oxidoreductase
REACTION    Dihydrophloroglucinol + NADP = Phloroglucinol + NADPH
SUBSTRATE   Dihydrophloroglucinol
            NADP
PRODUCT     Phloroglucinol
            NADPH
COMMENT     Involved in the gallate anaerobic degradation pathway in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.57
            ExPASy - ENZYME nomenclature database: 1.3.1.57
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.57
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.57
///
ENTRY       EC 1.3.1.58
NAME        2,3-Dihydroxy-2,3-dihydro-p-cumate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-2,3-Dihydroxy-2,3-dihydro-p-cumate:NAD oxidoreductase
REACTION    cis-5,6-Dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD =
            2,3-Dihydroxy-p-cumate + NADH
SUBSTRATE   cis-5,6-Dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate
            NAD
PRODUCT     2,3-Dihydroxy-p-cumate
            NADH
COMMENT     Involved in the p-cymene degradation pathway in Pseudomonas putida.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.58
            ExPASy - ENZYME nomenclature database: 1.3.1.58
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.58
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.58
///
ENTRY       EC 1.3.1.59
NAME        1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate:NAD
            oxidoreductase (decarboxylating)
REACTION    1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD = 3-
            Methylcatechol + CO2 + NADH
SUBSTRATE   1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate
            NAD
PRODUCT     3-Methylcatechol
            CO2
            NADH
COMMENT     Involved in the m-xylene degradation pathway in bacteria.
PATHWAY     PATH: MAP00624  Xylene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.59
            ExPASy - ENZYME nomenclature database: 1.3.1.59
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.59
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.59
///
ENTRY       EC 1.3.1.60
NAME        Dibenzothiophene dihydrodiol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-1,2-Dihydroxy-1,2-dihydrodibenzothiophene:NAD oxidoreductase
REACTION    cis-1,2-Dihydroxy-1,2-dihydrodibenzothiophene + NAD = 1,2-
            Dihydroxydibenzothiophene + NADH
SUBSTRATE   cis-1,2-Dihydroxy-1,2-dihydrodibenzothiophene
            NAD
PRODUCT     1,2-Dihydroxydibenzothiophene
            NADH
COMMENT     Involved in the dibenzothiophene degradation pathway in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.60
            ExPASy - ENZYME nomenclature database: 1.3.1.60
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.60
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.60
///
ENTRY       EC 1.3.1.61
NAME        Terephthalate 1,2-cis-dihydrodiol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD
            oxidoreductase (decarboxylating)
REACTION    cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD =
            3,4-Dihydroxybenzoate + CO2 + NADH
SUBSTRATE   cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate
            NAD
PRODUCT     3,4-Dihydroxybenzoate
            CO2
            NADH
COMMENT     Involved in the terephthalate degradation pathway in bacteria.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.61
            ExPASy - ENZYME nomenclature database: 1.3.1.61
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.61
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.61
///
ENTRY       EC 1.3.1.62
NAME        Pimeloyl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Pimeloyl-CoA:NAD oxidoreductase
REACTION    Pimeloyl-CoA + NAD = 6-Carboxyhex-2-enoyl-CoA + NADH
SUBSTRATE   Pimeloyl-CoA
            NAD
PRODUCT     6-Carboxyhex-2-enoyl-CoA
            NADH
COMMENT     Involved in the benzoate degradation (anaerobic) pathway in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.62
            ExPASy - ENZYME nomenclature database: 1.3.1.62
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.62
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.62
///
ENTRY       EC 1.3.1.63
NAME        2,4-Dichlorobenzoyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     4-Chlorobenzoyl-CoA:NADP oxidoreductase (halogenating)
REACTION    4-Chlorobenzoyl-CoA + NADP + HCl = 2,4-Dichlorobenzoyl-CoA + NADPH
SUBSTRATE   4-Chlorobenzoyl-CoA
            NADP
            HCl
PRODUCT     2,4-Dichlorobenzoyl-CoA
            NADPH
COMMENT     Acts in the reverse direction to form part of the 2,4-
            dichlorobenzoate degradation pathway in bacteria.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.63
            ExPASy - ENZYME nomenclature database: 1.3.1.63
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.63
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.63
///
ENTRY       EC 1.3.1.64
NAME        Phthalate 4,5-cis-dihydrodiol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD
            oxidoreductase
REACTION    cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD =
            4,5-Dihydroxyphthalate + NADH
SUBSTRATE   cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
            NAD
PRODUCT     4,5-Dihydroxyphthalate
            NADH
COMMENT     Involved in the phthalate degradation pathway in bacteria.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.64
            ExPASy - ENZYME nomenclature database: 1.3.1.64
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.64
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.64
///
ENTRY       EC 1.3.1.65
NAME        5,6-Dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline
            dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,6-Dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline:NAD
            oxidoreductase
REACTION    5,6-Dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + NAD =
            5,6-Dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline + NADH
SUBSTRATE   5,6-Dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline
            NAD
PRODUCT     5,6-Dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline
            NADH
COMMENT     Acts in the reverse direction to form part of the 3-methylquinoline
            degradation pathway in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.65
            ExPASy - ENZYME nomenclature database: 1.3.1.65
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.65
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.65
///
ENTRY       EC 1.3.1.66
NAME        cis-Dihydroethylcatechol dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-1,2-Dihydro-3-ethylcatechol:NAD oxidoreductase
REACTION    cis-1,2-Dihydro-3-ethylcatechol + NAD = 3-Ethylcatechol + NADH
SUBSTRATE   cis-1,2-Dihydro-3-ethylcatechol
            NAD
PRODUCT     3-Ethylcatechol
            NADH
COMMENT     Involved in the ethylbenzene degradation pathway in bacteria.
PATHWAY     PATH: MAP00642  Ethylbenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.66
            ExPASy - ENZYME nomenclature database: 1.3.1.66
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.66
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.66
///
ENTRY       EC 1.3.1.67
NAME        cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate
            dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)
            oxidoreductase (decarboxylating)
REACTION    cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate +
            NAD(P) = 4-Methylcatechol + NAD(P)H + CO2
SUBSTRATE   cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate
            NAD
            NADP
PRODUCT     4-Methylcatechol
            NADH
            NADPH
            CO2
COMMENT     Involved in the p-xylene degradation pathway in bacteria.
PATHWAY     PATH: MAP00624  Xylene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.67
            ExPASy - ENZYME nomenclature database: 1.3.1.67
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.67
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.67
///
ENTRY       EC 1.3.1.68
NAME        1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD
            oxidoreductase (decarboxylating)
REACTION    1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD = 3-
            Methylcatechol + NADH + CO2
SUBSTRATE   1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate
            NAD
PRODUCT     3-Methylcatechol
            NADH
            CO2
COMMENT     Involved in the o-xylene degradation pathway in bacteria.
PATHWAY     PATH: MAP00624  Xylene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.1.68
            ExPASy - ENZYME nomenclature database: 1.3.1.68
            WIT (What Is There) Metabolic Reconstruction: 1.3.1.68
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.68
///
ENTRY       EC 1.3.2.1
NAME        Transferred to EC 1.3.99.2
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With a cytochrome as acceptor
COMMENT     Transferred entry. Now EC 1.3.99.2 - Butyryl-CoA dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.2.1
            ExPASy - ENZYME nomenclature database: 1.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.2.1
///
ENTRY       EC 1.3.2.2
NAME        Transferred to EC 1.3.99.3
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With a cytochrome as acceptor
COMMENT     Transferred entry. Now EC 1.3.99.3 - Acyl-CoA dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.2.2
            ExPASy - ENZYME nomenclature database: 1.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.3.2.2
///
ENTRY       EC 1.3.2.3
NAME        Galactonolactone dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With a cytochrome as acceptor
SYSNAME     L-Galactono-1,4-lactone:ferricytochrome-c oxidoreductase
REACTION    L-Galactono-1,4-lactone + 2 Ferricytochrome c = L-Ascorbate +
            2 Ferrocytochrome c
SUBSTRATE   L-Galactono-1,4-lactone
            Ferricytochrome c
PRODUCT     L-Ascorbate
            Ferrocytochrome c
COMMENT     cf. EC 1.1.3.24.
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.2.3
            ExPASy - ENZYME nomenclature database: 1.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 1.3.2.3
            BRENDA, the Enzyme Database: 1.3.2.3
///
ENTRY       EC 1.3.3.1
NAME        Dihydroorotate oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Dihydroorotate:oxygen oxidoreductase
REACTION    (S)-Dihydroorotate + O2 = Orotate + H2O2
SUBSTRATE   (S)-Dihydroorotate
            O2
            Ferricyanide
PRODUCT     Orotate
            H2O2
COFACTOR    FAD
            FMN
COMMENT     A flavoprotein (FAD, FMN). Ferricyanide can act as acceptor.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b0945(pyrD)
            ECE: Z1294(pyrD)
            ECS: ECs1029
            YPE: YPO1415(pyrD)
            HIN: HI1401(pyrD)
            PMU: PM0617(pyrD)
            XFA: XF2571
            VCH: VC1491
            PAE: PA3050(pyrD)
            BUC: BU362(pyrD)
            NME: NMB0221
            NMA: NMA0042(pyrD)
            HPY: HP1011(pyrD)
            HPJ: jhp0412
            CJE: Cj0804(pyrD)
            MLO: mll5681
            SME: SMc02245(pyrD)
            CCR: CC0528
            BSU: BG10718(pyrDI)
            BHA: BH2534(pyrD)
            SAU: SA2375
            SAV: SAV2572(pyrD)
            LLA: L182555(pydB) L192589(pydA)
            SPY: SPy1432(pyrD)
            SPN: SP0764 SP0964
            SPR: spr0672(pyrDA) spr0866(pyrD)
            CAC: CAC2650(pyrD)
            MTU: Rv2139(pyrD)
            MTC: MT2197
            MLE: ML1293(pyrD)
            SYN: slr1418(pyrD)
            DRA: DR0501
            AAE: aq_046(pyrD)
            TMA: TM0333
            MJA: MJ0654(pyrD)
            MTH: MTH1213
            AFU: AF0745(pyrD)
            HAL: VNG2507G(pyrD)
            TAC: Ta0404
            TVO: TVG1224769
            PHO: PH1516
            PAB: PAB1936(pyrD)
            APE: APE0260
            SSO: SSO0610(pyrD)
            SCE: YKL216W(URA1)
            SPO: URA3(ura3)
            CEL: W02D3.2
            DME: CG9741(Dhod)
            HSA: 1723(DHODH)
MOTIF       PS: PS00911  [GS]-x(4)-[GK]-[GSTA]-[LIVFSTA]-[GST]-x(3)-[NQR]-x-G-
                         [NHY]-x(2)-P-[RT]
            PS: PS00912  [LIVM](2)-[GSA]-x-G-G-[IV]-x-[STGDN]-x(3)-[ACV]-x(6)-G-
                         A
STRUCTURES  PDB: 2DOR  1D3G  1D3H  1DOR  1EP1  1EP2  1EP3  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.1
            ExPASy - ENZYME nomenclature database: 1.3.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.1
            BRENDA, the Enzyme Database: 1.3.3.1
            SCOP (Structural Classification of Proteins): 1.3.3.1
///
ENTRY       EC 1.3.3.2
NAME        Lathosterol oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     5alpha-Cholest-7-en-3beta-ol:oxygen delta5-oxidoreductase
REACTION    5alpha-Cholest-7-en-3beta-ol + O2 = Cholesta-5,7-dien-3beta-ol +
            H2O2
SUBSTRATE   5alpha-Cholest-7-en-3beta-ol
            O2
            Ferricyanide
PRODUCT     Cholesta-5,7-dien-3beta-ol
            H2O2
COFACTOR    FAD
            FMN
COMMENT     A flavoprotein (FAD, FMN).  Ferricyanide can act as acceptor.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       HSA: 6309(SC5DL)
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.2
            ExPASy - ENZYME nomenclature database: 1.3.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.2
            BRENDA, the Enzyme Database: 1.3.3.2
///
ENTRY       EC 1.3.3.3
NAME        Coproporphyrinogen oxidase
            Coproporphyrinogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     Coproporphyrinogen:oxygen oxidoreductase(decarboxylating)
REACTION    Coproporphyrinogen III + O2 = Protoporphyrinogen IX + 2 CO2
SUBSTRATE   Coproporphyrinogen III
            O2
PRODUCT     Protoporphyrinogen IX
            CO2
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b2436(hemF)
            ECE: Z3701(hemF)
            ECS: ECs3307
            YPE: YPO3032(hemF)
            XFA: XF0017
            VCH: VC0055
            PAE: PA0024(hemF)
            RPR: RP882(hemF)
            RCO: RC1369(hemF)
            MLO: mlr2722
            SME: SMc00180(hemF)
            CCR: CC0506
            SPR: spr1266(hemN)
            SYN: sll1185(hemF)
            SCE: YDR044W(HEM13)
            SPO: SPAC222.11(spac222.11)
            DME: CG3433(BcDNA:GM14838)
            HSA: 1371(CPO)
DISEASE     MIM: 121300  Coproporphyrinogen oxidase
MOTIF       PS: PS01021  K-x-[WQ]-[CA]-x(2)-[FYH](2)-x-[LIVM]-x-H-R-x-E-x-R-G-
                         [LIVM]-G-G-[LIVM]-F-[FY]-D
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.3
            ExPASy - ENZYME nomenclature database: 1.3.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.3
            BRENDA, the Enzyme Database: 1.3.3.3
///
ENTRY       EC 1.3.3.4
NAME        Protoporphyrinogen oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     Protoporphyrinogen-IX:oxygen oxidoreductase
REACTION    Protoporphyrinogen IX + O2 = Protoporphyrin IX + H2O
SUBSTRATE   Protoporphyrinogen IX
            O2
PRODUCT     Protoporphyrin IX
            H2O
COMMENT     Also slowly oxidizes mesoporphyrinogen-IX.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b3850(hemG)
            ECE: Z5372(hemG)
            ECS: ECs4778
            YPE: YPO3761(hemG)
            PMU: PM1499
            VCH: VC2755
            RCO: RC1314(hemK)
            MLO: mlr4722
            BSU: BG10431(hemY)
            BHA: BH1204(hemY)
            SAU: SA1650(hemY)
            SAV: SAV1816(hemY)
            MTU: Rv2677c(hemY')
            MTC: MT2751
            MLE: ML1044(hemY)
            CTR: CT745
            CMU: TC0121
            CPN: CPn0888
            CPA: CP0978
            CPJ: hemG
            DRA: DR1130
            AAE: aq_2015(hemG)
            SCE: YER014W(HEM14)
            SPO: SPAC1F5.07C(spac1f5.07c)
            ATH: At4g01690(T15B16.13)
            DME: CG5796
            HSA: 5498(PPOX)
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.4
            ExPASy - ENZYME nomenclature database: 1.3.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.4
            BRENDA, the Enzyme Database: 1.3.3.4
///
ENTRY       EC 1.3.3.5
NAME        Bilirubin oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     Bilirubin:oxygen oxidoreductase
REACTION    Bilirubin + O2 = Biliverdin + H2O
SUBSTRATE   Bilirubin
            O2
PRODUCT     Biliverdin
            H2O
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.5
            ExPASy - ENZYME nomenclature database: 1.3.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.5
            BRENDA, the Enzyme Database: 1.3.3.5
///
ENTRY       EC 1.3.3.6
NAME        Acyl-CoA oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     Acyl-CoA:oxygen 2-oxidoreductase
REACTION    Acyl-CoA + O2 = trans-2,3-Dehydroacyl-CoA + H2O2
SUBSTRATE   Acyl-CoA
            O2
PRODUCT     trans-2,3-Dehydroacyl-CoA
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Acts on CoA derivatives of fatty acids
            with chain length from 8 to 18.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       SCE: YGL205W(POX1)
            CEL: C48B4.1 F08A8.1 F08A8.2 F08A8.3 F08A8.4 F25C8.1 F59F4.1
            DME: CG5009(BcDNA:GH07485)
            HSA: 51(ACOX1)
DISEASE     MIM: 264470  Acyl-Coenzyme A oxidase 1
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.6
            ExPASy - ENZYME nomenclature database: 1.3.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.6
            BRENDA, the Enzyme Database: 1.3.3.6
///
ENTRY       EC 1.3.3.7
NAME        Dihydrouracil oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     5,6-Dihydrouracil:oxygen oxidoreductase
REACTION    5,6-Dihydrouracil + O2 = Uracil + H2O2
SUBSTRATE   5,6-Dihydrouracil
            O2
            Dihydrothymine
PRODUCT     Uracil
            H2O2
            Thymine
COFACTOR    FMN
COMMENT     Also oxidizes dihydrothymine to thymine.  A flavoprotein (FMN).
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.7
            ExPASy - ENZYME nomenclature database: 1.3.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.7
            BRENDA, the Enzyme Database: 1.3.3.7
///
ENTRY       EC 1.3.3.8
NAME        Tetrahydroberberine oxidase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Tetrahydroberberine:oxigen oxidoreductase
REACTION    (S)-Tetrahydroberberine + 2 O2 = Berberine + 2 H2O2;
            (S)-Tetrahydrocolumbamine + 2 O2 = Columbamine + 2 H2O2
SUBSTRATE   (S)-Tetrahydroberberine
            O2
            (S)-Tetrahydrocolumbamine
PRODUCT     Berberine
            H2O2
            Columbamine
COMMENT     The enzyme from berberis sp.  (prevously listed as EC 1.5.3.8) is
            a flavoprotein; that form Coptis japonica is not.
            (R)-Tetrahydroberberines are not oxidized.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.3.8
            ExPASy - ENZYME nomenclature database: 1.3.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.3.3.8
            BRENDA, the Enzyme Database: 1.3.3.8
///
ENTRY       EC 1.3.5.1
NAME        Succinate dehydrogenase (ubiquinone)
            Succinic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With a quinone or related compound as acceptor
SYSNAME     Succinate:ubiquinone oxidoreductase
REACTION    Succinate + Ubiquinone = Fumarate + Ubiquinol
SUBSTRATE   Succinate
            Ubiquinone
PRODUCT     Fumarate
            Ubiquinol
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein (FAD) containing iron-sulfur centres. The complex,
            present in mitochondria, can be degraded to form EC 1.3.99.1,
            which no longer reacts with ubiquinone.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP03150  
GENES       SCE: YDR178W(SDH4) YJL045W YKL141W(SDH3) YKL148C(SDH1)
                 YLL041C(SDH2) YLR164W YMR118C
            SPO: SPAC1556.02C(spac1556.02c) SPBP23A10.16(spbp23a10.16)
                 SPCC330.12C(spcc330.12c)
            ATH: At2g18450(T30D6.4) At3g27380(K1G2.19) At5g40650(MNF13.170)
                 At5g66760(MSN2.16)
            CEL: C03G5.1 C34B2.7 F33A8.5 F42A8.2 cyt-1
            DME: CG10219 CG17246(Scs-fp) CG3283(SdhB) CG5718 CG6629 CG6666
                 CG7349
            HSA: 6389(SDHA) 6390(SDHB) 6391(SDHC) 6392(SDHD)
DISEASE     MIM: 185470  Succinate dehydrogenase complex, subunit B, iron
                         sulfur (Ip)
            MIM: 600857  Succinate dehydrogenase complex, subunit A,
                         flavoprotein
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00504  R-[ST]-H-[ST]-x(2)-A-x-G-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.5.1
            ExPASy - ENZYME nomenclature database: 1.3.5.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.5.1
            BRENDA, the Enzyme Database: 1.3.5.1
///
ENTRY       EC 1.3.7.1
NAME        6-Hydroxynicotinate reductase
            6-Oxotetrahydro-nicotinate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     1,4,5,6-Tetrahydronicotinate:ferredoxin oxidoreductase
REACTION    1,4,5,6-Tetrahydro-6-oxonicotinate + Oxidized ferredoxin =
            6-Hydroxynicotinate + Reduced ferredoxin
SUBSTRATE   1,4,5,6-Tetrahydro-6-oxonicotinate
            Oxidized ferredoxin
PRODUCT     6-Hydroxynicotinate
            Reduced ferredoxin
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.7.1
            ExPASy - ENZYME nomenclature database: 1.3.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.7.1
            BRENDA, the Enzyme Database: 1.3.7.1
///
ENTRY       EC 1.3.99.1
NAME        Succinate dehydrogenase
            Succinic dehydrogenase
            Fumarate reductase
            Fumaric hydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Succinate:(acceptor) oxidoreductase
REACTION    Succinate + Acceptor = Fumarate + Reduced acceptor
SUBSTRATE   Succinate
            Acceptor
PRODUCT     Fumarate
            Reduced acceptor
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein (FAD) containing iron-sulfur centres. A component
            of EC 1.3.5.1. (EC 1.3.5.1 Succinate dehydrogenase)
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP00650  Butanoate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
            PATH: MAP03150  
GENES       ECO: b0721(sdhC) b0722(sdhD) b0723(sdhA) b0724(sdhB) b4151(frdD)
                 b4152(frdC) b4153(frdB) b4154(frdA)
            ECE: Z0875(sdhC) Z0876(sdhD) Z0877(sdhA) Z0878(sdhB) Z5758(frdD)
                 Z5759(frdC) Z5760(frdB) Z5762(frdA)
            ECS: ECs0746 ECs0747 ECs0748 ECs0749 ECs5132 ECs5133 ECs5134
                 ECs5135
            YPE: YPO0357(frdD) YPO0358(frdC) YPO0359(frdB) YPO0360(frdA)
                 YPO1109(sdhC) YPO1110(sdhD) YPO1111(sdhA) YPO1112(sdhB)
            HIN: HI0832(frdD) HI0833(frdC) HI0834(frdB) HI0835(frdA)
            PMU: PM0198(frdD) PM0199(frdC) PM0200(frdB) PM0201(frdA)
            XFA: XF1070 XF1071 XF1072 XF1073
            VCH: VC2088 VC2089 VC2090 VC2091 VC2656 VC2657 VC2658 VC2659
            PAE: PA1581(sdhC) PA1582(sdhD) PA1583(sdhA) PA1584(sdhB)
            NME: NMB0948 NMB0949 NMB0950 NMB0951
            NMA: NMA1143(sdhC) NMA1144(sdhD) NMA1145(sdhA) NMA1146(sdhB)
            HPY: HP0191(frdB) HP0192(frdA) HP0193(frdC)
            HPJ: jhp0177 jhp0178 jhp0179
            CJE: Cj0408(frdC) Cj0409(frdA) Cj0410(frdB) Cj0437(sdhA)
                 Cj0438(sdhB) Cj0439(sdhC)
            RPR: RP044(sdhB) RP126(sdhC) RP127(sdhD) RP128(sdhA)
            RCO: RC0069(sdhB) RC0168(sdhC) RC0169(sdhD) RC0170(sdhA)
            MLO: mll4260 mll4263 mll4265 mll4266
            SME: SMc02463(sdhC) SMc02464(sdhD) SMc02465(sdhA) SMc02466(sdhB)
            ATU: AGR_C_4790 AGR_C_4792 AGR_C_4793 AGR_C_4794
            CCR: CC3526 CC3527 CC3528 CC3529
            BSU: BG10351(sdhC) BG10352(sdhA) BG10353(sdhB)
            BHA: BH3091(sdhB) BH3092(sdhA) BH3093(sdhC)
            SAU: SA0994(sdhC) SA0995(sdhA) SA0996(sdhB)
            SAV: SAV1128(sdhC) SAV1129(sdhA) SAV1130(sdhB)
            LLA: L137630(frdC)
            MTU: Rv0247c Rv0248c Rv1552(frdA) Rv1553(frdB) Rv1554(frdC)
                 Rv1555(frdD) Rv3316(sdhC) Rv3317(sdhD) Rv3318(sdhA)
                 Rv3319(sdhB)
            MTC: MT0261 MT0262 MT1603 MT1604 MT1605 MT1606 MT3417 MT3418
                 MT3419 MT3420
            MLE: ML0696(sdhB) ML0697(sdhA) ML0698(sdhD) ML0699(sdhC)
            CTR: CT591 CT592 CT593
            CMU: TC0880 TC0881 TC0882
            CPN: CPn0788 CPn0789 CPn0790
            CPA: CP1082 CP1083 CP1084
            CPJ: sdhA sdhB sdhC
            SYN: sll0823(sdhB) sll1625(sdhB) slr1233(frdA)
            DRA: DR0951 DR0952 DR0953 DR0954
            AAE: aq_553(frdB1) aq_594(frdA) aq_655(frdB2)
            TMA: TM0427
            MJA: MJ0033 MJ0092
            MTH: MTH1502 MTH1850
            AFU: AF0681(sdhA) AF0682(sdhB) AF0683(sdhC) AF0684(sdhD)
                 AF1463(fdrA)
            HAL: VNG1306G(sdhA) VNG1308G(sdhB) VNG1309G(sdhD) VNG1310G(sdhC)
            TAC: Ta1001 Ta1002 Ta1003 Ta1004
            TVO: TVG0760262 TVG0760633 TVG0761062 TVG0761794
            APE: APE0946 APE0947 APE0948 APE0950
            SSO: SSO2356(sdhA) SSO2357(sdhB) SSO2358(sdhC)
            STO: ST0497 ST0498 ST0499
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
            PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00504  R-[ST]-H-[ST]-x(2)-A-x-G-G
STRUCTURES  PDB: 1QLB  1D4C  1D4D  1D4E  1E7P  1QLA  1QO8  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.1
            ExPASy - ENZYME nomenclature database: 1.3.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.1
            BRENDA, the Enzyme Database: 1.3.99.1
            SCOP (Structural Classification of Proteins): 1.3.99.1
///
ENTRY       EC 1.3.99.2
NAME        Butyryl-CoA dehydrogenase
            Butyryl dehydrogenase
            Unsaturated acyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Butanoyl-CoA:(acceptor) 2,3-oxidoreductase
REACTION    Butanoyl-CoA + Acceptor = 2-Butenoyl-CoA + Reduced acceptor
SUBSTRATE   Butanoyl-CoA
            Acceptor
PRODUCT     2-Butenoyl-CoA
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein; forms with another flavoprotein ('electoron-
            -transferring flavoprotein') and EC 1.5.5.1 a system reducing
            ubiquinone and other acceptors.  Formerly EC 1.3.2.1.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00650  Butanoate metabolism
GENES       CAC: CAC2711(bcd)
            AFU: AF1175(acdS)
            MMU: 87868(Acads)
            HSA: 35(ACADS)
DISEASE     MIM: 201470  Acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain
MOTIF       PS: PS00072  [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]
            PS: PS00073  [QDE]-x(2)-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-
                         x(3)-[DEN]
STRUCTURES  PDB: 1BUC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.2
            ExPASy - ENZYME nomenclature database: 1.3.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.2
            BRENDA, the Enzyme Database: 1.3.99.2
            SCOP (Structural Classification of Proteins): 1.3.99.2
///
ENTRY       EC 1.3.99.3
NAME        Acyl-CoA dehydrogenase
            Acyl dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Acyl-CoA:(acceptor) 2,3-oxidoreductase
REACTION    Acyl-CoA + Acceptor = 2,3-Dehydroacyl-CoA + Reduced acceptor
SUBSTRATE   Acyl-CoA
            Acceptor
            2-Methylpropanoyl-CoA
            2-Methylbutanoyl-CoA
            3-Methylbutanoyl-CoA
PRODUCT     2,3-Dehydroacyl-CoA
            Reduced acceptor
            2-Methylprop-2-enoyl-CoA
            2-Methylbut-2-enoyl-CoA
            3-Methylbut-2-enoyl-CoA
COFACTOR    FAD
COMMENT     A flavoprotein; forms with another flavoprotein ('electron-
            -transferring flavoprotein') and EC 1.5.5.1 a system reducing
            ubiquinone and other acceptors. Formerly EC 1.3.2.2.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       PAE: PA0879 PA1187 PA1535 PA2015 PA2550 PA4435 PA4994
            MLO: mll3094 mlr5042 mlr5626
            SME: SMc01639
            CCR: CC0079 CC0690 CC1110 CC2328
            MTU: Rv0131c(fadE1) Rv0154c(fadE2) Rv0231(fadE4) Rv0975c(fadE13)
                 Rv2724c(fadE20) Rv3140(fadE23)
            MTC: MT0139 MT0163 MT0241 MT1003 MT2796 MT3227
            MLE: ML0660(fadE23)
            DRA: DR1318 DRA0196
            AFU: AF0199(acd-1) AF0436(acd-2) AF0498(acd-3) AF0671(acd-4)
                 AF0845(acd-5) AF0964(acd-6) AF1026(acd-7) AF1141(acd-8)
                 AF1293(acd-9) AF2057(acd-10) AF2275(acd-12)
            TAC: Ta0295 Ta0398
            TVO: TVG1231223 TVG1371752
            APE: APE0385 APE0739 APE1681 APE2158 APE2354
            CEL: C17C3.12 K05F1.3 K06A5.6 T08G2.3 T10E9.9 T25G12.5
            DME: CG12262
            MMU: 87867(Acadm)
            HSA: 34(ACADM) 36(ACADSB)
DISEASE     MIM: 201450  Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight
                         chain
MOTIF       PS: PS00072  [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]
            PS: PS00073  [QDE]-x(2)-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-
                         x(3)-[DEN]
STRUCTURES  PDB: 3MDE  3MDD  1EGC  1EGD  1EGE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.3
            ExPASy - ENZYME nomenclature database: 1.3.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.3
            BRENDA, the Enzyme Database: 1.3.99.3
            SCOP (Structural Classification of Proteins): 1.3.99.3
///
ENTRY       EC 1.3.99.4
NAME        3-Oxosteroid 1-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     3-Oxosteroid:(acceptor) delta1-oxidoreductase
REACTION    3-Oxosteroid + Acceptor = 3-Oxo-delta1-steroid +
            Reduced acceptor
SUBSTRATE   3-Oxosteroid
            Acceptor
PRODUCT     3-Oxo-delta1-steroid
            Reduced acceptor
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.4
            ExPASy - ENZYME nomenclature database: 1.3.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.4
            BRENDA, the Enzyme Database: 1.3.99.4
///
ENTRY       EC 1.3.99.5
NAME        3-Oxo-5alpha-steroid 4-dehydrogenase
            Steroid 5alpha-reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     3-Oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase
REACTION    a 3-Oxo-5alpha-steroid + Acceptor = a 3-Oxo-delta4-steroid +
            Reduced acceptor
SUBSTRATE   3-Oxo-5alpha-steroid
            Acceptor
PRODUCT     3-Oxo-delta4-steroid
            Reduced acceptor
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00150  Androgen and estrogen metabolism
GENES       ATH: At2g38050(T8P21.4)
            CEL: F19H6.4 F42F12.3
            MMU: 98400(Srd5a1)
            HSA: 6715(SRD5A1) 6716(SRD5A2)
DISEASE     MIM: 184753  Steroid-5-alpha-reductase, alpha polypeptide 1
                         (3-oxo-5 alpha-steroid
            MIM: 264600  Steroid-5-alpha-reductase, alpha polypeptide-2
                         (3-oxo-5 alpha-steroid
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.5
            ExPASy - ENZYME nomenclature database: 1.3.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.5
            BRENDA, the Enzyme Database: 1.3.99.5
///
ENTRY       EC 1.3.99.6
NAME        3-Oxo-5beta-steroid 4-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     3-Oxo-5beta-steroid:(acceptor) delta4-oxidoreductase
REACTION    a 3-Oxo-5beta-steroid + Acceptor = a 3-Oxo-delta4-steroid +
            Reduced acceptor
SUBSTRATE   3-Oxo-5beta-steroid
            Acceptor
PRODUCT     3-Oxo-delta4-steroid
            Reduced acceptor
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
GENES       HSA: 6718(AKR1D1)
MOTIF       PS: PS00062  [LIVMFY]-x(9)-[KREQ]-x-[LIVM]-G-[LIVM]-[SC]-N-[FY]
            PS: PS00063  [LIVM]-[PAIV]-[KR]-[ST]-x(4)-R-x(2)-[GSTAEQK]-[NSL]-
                         x(2)-[LIVMFA]
            PS: PS00798  G-[FY]-R-[HSAL]-[LIVMF]-D-[STAGC]-[AS]-x(5)-E-x(2)-
                         [LIVM]-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.6
            ExPASy - ENZYME nomenclature database: 1.3.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.6
            BRENDA, the Enzyme Database: 1.3.99.6
///
ENTRY       EC 1.3.99.7
NAME        Glutaryl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)
REACTION    Glutaryl-CoA + Acceptor = Crotonoyl-CoA + CO2 + Reduced acceptor
SUBSTRATE   Glutaryl-CoA
            Acceptor
PRODUCT     Crotonoyl-CoA
            CO2
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
GENES       PAE: PA0447(gcdH)
            MLO: mll2878
            SME: SMb21181
            SAU: SA0225
            SAV: SAV0226(gcdH)
            MTU: Rv0400c(fadE7)
            MTC: MT0410
            DRA: DR0551 DRA0337
            AFU: AF0991(gcdH)
            HAL: VNG2499G(gcdH)
            CEL: F54D5.7
            DME: CG9547
            MMU: 104541(Gcdh)
            HSA: 2639(GCDH)
DISEASE     MIM: 231670  Glutaryl-Coenzyme A dehydrogenase
MOTIF       PS: PS00072  [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]
            PS: PS00073  [QDE]-x(2)-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-
                         x(3)-[DEN]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.7
            ExPASy - ENZYME nomenclature database: 1.3.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.7
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.7
            BRENDA, the Enzyme Database: 1.3.99.7
///
ENTRY       EC 1.3.99.8
NAME        2-Furoyl-CoA dehydrogenase
            Furoyl-CoA hydroxylase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     2-Furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)
REACTION    2-Furoyl-CoA + H2O + Acceptor = S-(5-Hydroxy-2-furoyl)-CoA +
            Reduced acceptor
SUBSTRATE   2-Furoyl-CoA
            H2O
            Acceptor
            Methylene blue
            Nitro blue
            Tetrazolium
PRODUCT     S-(5-Hydroxy-2-furoyl)-CoA
            Reduced acceptor
COFACTOR    Copper
COMMENT     A copper protein.  The exygen atom of the -OH produced is derived
            from water, not O2; the actual oxidative step is probably
            dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-,
            which tautomerizes non-enzymically to -CO-CH2-, giving
            (5-oxo-4,5-dihydro-2-furoyl)-CoA.  Methylene blue, nitro blue,
            tetrazolium and a membrane fraction from P. putida can act as
            acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.8
            ExPASy - ENZYME nomenclature database: 1.3.99.8
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.8
            BRENDA, the Enzyme Database: 1.3.99.8
///
ENTRY       EC 1.3.99.9
NAME        beta-Cyclopiazonate dehydrogenase
            beta-Cyclopiazonate oxidocyclase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     beta-Cyclopiazonate:(acceptor) oxidoreductase (cyclizing)
REACTION    beta-Cyclopiazonate + Acceptor = alpha-Cyclopiazonate +
            Reduced acceptor
SUBSTRATE   beta-Cyclopiazonate
            Acceptor
            Cytochrome c
PRODUCT     alpha-Cyclopiazonate
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Cytochrome c and various dyes can act as
            acceptor.  Cyclopiazonate is a microbial toxin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.9
            ExPASy - ENZYME nomenclature database: 1.3.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.9
            BRENDA, the Enzyme Database: 1.3.99.9
///
ENTRY       EC 1.3.99.10
NAME        Isovaleryl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     3-Methylbutanoyl-CoA:(acceptor) oxidoreductase
REACTION    3-Methylbutanoyl-CoA + Acceptor = 3-Methylbut-2-enoyl-CoA +
            Reduced acceptor
SUBSTRATE   3-Methylbutanoyl-CoA
            n-Pentanoate
            Acceptor
PRODUCT     3-Methylbut-2-enoyl-CoA
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein; forms with electron-transferring flavoprotein
            and EC 1.5.5.1 a system reducing ubiquinone. n-Pentanoate can
            act as donor. Not identical with EC 1.3.99.2, 1.3.99.3 or
            1.3.99.12.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
GENES       MLO: mll7732
            SME: SMb21121(ivdH)
            CCR: CC2172
            CEL: C02B10.1 C02D5.1
            DME: CG6638
            HSA: 3712(IVD)
DISEASE     MIM: 243500  Isovaleryl Coenzyme A dehydrogenase
MOTIF       PS: PS00072  [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]
            PS: PS00073  [QDE]-x(2)-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-
                         x(3)-[DEN]
STRUCTURES  PDB: 1IVH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.10
            ExPASy - ENZYME nomenclature database: 1.3.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.10
            BRENDA, the Enzyme Database: 1.3.99.10
            SCOP (Structural Classification of Proteins): 1.3.99.10
///
ENTRY       EC 1.3.99.11
NAME        Dihydroorotate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     (S)-Dihydroorotate:(acceptor) oxidoreductase
REACTION    (S)-Dihydroorotate + Acceptor = Orotate + Reduced acceptor
SUBSTRATE   (S)-Dihydroorotate
            Acceptor
            O2
            2,6-Dichloroindophenol
            1,10-Phenanthroline
PRODUCT     Orotate
            Reduced acceptor
            H2O
            2,6-Dichlorophenol-4-(p-benzoquinone imine)
COFACTOR    Iron
            Zinc
COMMENT     An iron-zinc protein. Oxygen can act as acceptor, but much
            more slowly than 2,6-dichloroindophenol or 1,10-phenanthroline.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
MOTIF       PS: PS00911  [GS]-x(4)-[GK]-[GSTA]-[LIVFSTA]-[GST]-x(3)-[NQR]-x-G-
                         [NHY]-x(2)-P-[RT]
            PS: PS00912  [LIVM](2)-[GSA]-x-G-G-[IV]-x-[STGDN]-x(3)-[ACV]-x(6)-G-
                         A
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.11
            ExPASy - ENZYME nomenclature database: 1.3.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.11
            BRENDA, the Enzyme Database: 1.3.99.11
///
ENTRY       EC 1.3.99.12
NAME        2-Methylacyl-CoA dehydrogenase
            Branched-chain acyl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     2-Methylbutanoyl-CoA:(acceptor) oxidoreductase
REACTION    2-Methylbutanoyl-CoA + Acceptor = 2-Methylbut-2-enoyl-CoA +
            Reduced acceptor
SUBSTRATE   2-Methylbutanoyl-CoA
            Acceptor
            2-Methylpropanoyl-CoA
PRODUCT     2-Methylbut-2-enoyl-CoA
            Reduced acceptor
            2-Methylprop-2-enoyl-CoA
COMMENT     Also oxidizes 2-methylpropanoyl-CoA.  Not identical with
            EC 1.3.99.2, 1.3.99.3, 1.3.99.10 or 1.3.99.13.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.12
            ExPASy - ENZYME nomenclature database: 1.3.99.12
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.12
            BRENDA, the Enzyme Database: 1.3.99.12
///
ENTRY       EC 1.3.99.13
NAME        Long-chain-acyl-CoA dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase
REACTION    Acyl-CoA + Acceptor = 2,3-Dehydroacyl-CoA + Reduced acceptor
SUBSTRATE   Acyl-CoA
            Acceptor
PRODUCT     2,3-Dehydroacyl-CoA
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD); forms with another flavoprotein ('electron-
            -transferring flavoprotein') and EC 1.5.5.1 a system reducing
            ubiquinone and other acceptors. Not identical with EC 1.3.99.2,
            1.3.99.3, 1.3.99.10 or 1.3.99.12.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       MMU: 87866(Acadl)
            HSA: 33(ACADL)
DISEASE     MIM: 201460  Acyl-Coenzyme A dehydrogenase, long chain
MOTIF       PS: PS00072  [GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA]
            PS: PS00073  [QDE]-x(2)-G-[GS]-x-G-[LIVMFY]-x(2)-[DEN]-x(4)-[KR]-
                         x(3)-[DEN]
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.13
            ExPASy - ENZYME nomenclature database: 1.3.99.13
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.13
            BRENDA, the Enzyme Database: 1.3.99.13
///
ENTRY       EC 1.3.99.14
NAME        Cyclohexanone dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     Cyclohexanone:(acceptor) 2-oxidoreductase
REACTION    Cyclohexanone + Acceptor = Cyclohex-2-enone + Reduced acceptor
SUBSTRATE   Cyclohexanone
            Acceptor
            2,6-Dichloroindophenol
PRODUCT     Cyclohex-2-enone
            Reduced acceptor
COMMENT     2,6-Dichloroindophenol can act as acceptor.  The corresponding
            ketones of cyclopentane and cycloheptane cannot act as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.14
            ExPASy - ENZYME nomenclature database: 1.3.99.14
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.14
///
ENTRY       EC 1.3.99.15
NAME        Benzoyl-CoA reductase
            Benzoyl-CoA reductase (dearomatizing)
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
REACTION    Benzoyl-CoA + Reduced acceptor + 2 ATP =
            Cyclohexa-1,5-diene-1-carbonyl-CoA + Acceptor + 2 ADP +
            2 Phosphate;
            Hydroxylamine + Reduced acceptor + 2 ATP =
            Ammonia + Acceptor + 2 ADP + 2 Phosphate + H2O
SUBSTRATE   Benzoyl-CoA
            Reduced acceptor
            ATP
            Hydroxylamine
PRODUCT     Cyclohexa-1,5-diene-1-carbonyl-CoA
            Acceptor
            ADP
            Phosphate
            Ammonia
            H2O
COFACTOR    Manganese
            Magnesium
COMMENT     Reduced methyl viologen can act as electron donor.
            Inactive towards aromatic acids that are not CoA esters but will
            also catalyse the reaction: ammonia + acceptor + 2 ADP +
            2 phosphate + H2O = hydroxylamine + reduced acceptor + 2 ATP.
            In the presence of reduced acceptor, but in the absence of
            oxidizable substrate, the enzyme catalyses the hydrolysis of ATP to
            ADP plus phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.15
            ExPASy - ENZYME nomenclature database: 1.3.99.15
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.15
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.15
///
ENTRY       EC 1.3.99.16
NAME        Isoquinoline 1-oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
REACTION    Isoquinoline + Acceptor + H2O = Isoquinolin-1(2H)-one +
            Reduced acceptor
SUBSTRATE   Isoquinoline
            Acceptor
            H2O
PRODUCT     Isoquinolin-1(2H)-one
            Reduced acceptor
COMMENT     The enzyme from Pseudomonas diminuta is specific towards
            N-containing N-heterocyclic substrates, including isoquinoline,
            isoquinolin-5-ol, phthalazine and quinazoline.
            Electron acceptors include 1,2-benzoquinone, cytochrome c,
            ferricyanide, iodonitrotetrazolium chloride (INT), nitroblue
            tetrazolium (NBT), Meldola blue and phenazine methosulfate.
GENES       PAE: PA1880 PA1881
            CCR: CC0021 CC0022
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.16
            ExPASy - ENZYME nomenclature database: 1.3.99.16
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.16
///
ENTRY       EC 1.3.99.17
NAME        Quinoline 2-oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
REACTION    Quinoline + Acceptor + H2O = Isoquinolin-1(2H)-one +
            Reduced acceptor
SUBSTRATE   Quinoline
            Acceptor
            H2O
PRODUCT     Isoquinolin-1(2H)-one
            Reduced acceptor
COMMENT     In addition to quinoline, quinolin-2-ol, quinolin-7-ol,
            quinolin-8-ol, 3-, 4- and 8-methylquinolines and 8-chloroquinoline
            are substrates.
            Iodonitrotetrazolium chloride (INT) can act as an electron acceptor
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.17
            ExPASy - ENZYME nomenclature database: 1.3.99.17
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.17
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.17
///
ENTRY       EC 1.3.99.18
NAME        Quinaldate 4-oxidoreductase
            Quinaldic acid 4-oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
REACTION    Quinaldate + Acceptor + H2O = Kynurenate + Reduced acceptor
SUBSTRATE   Quinaldate
            Acceptor
            H2O
PRODUCT     Kynurenate
            Reduced acceptor
COMMENT     The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8-
            carboxylate, whereas that from Serratia marcescens 2CC-1 will
            oxidize nicotinate; quinaldate is a substrate for both of these
            enzymes. 2,4,6-Trinitrobenzene sulfonate acid, 1,4-benzoquinone,
            1,2-naphthoquinone, nitroblue tetrazolium (NBT), thionine and
            menadione will serve as an electron acceptor for the former enzyme
            and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium
            chloride (INT), phenazine methosulfate (PMS), 2,6-
            dichlorophenolindophenol (DCPIP) and cytochrome c will act as
            electron acceptors for both.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.18
            ExPASy - ENZYME nomenclature database: 1.3.99.18
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.18
///
ENTRY       EC 1.3.99.19
NAME        Quinoline-4-carboxylate 2-oxidoreductase
            Quinoline-4-carboxylic acid 2-oxidoreductase
            Quinaldic acid 4-oxidoreductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
REACTION    Quinoline-4-carboxylate + Acceptor + H2O = Quinolin-2(1H)-one +
            Reduced acceptor
SUBSTRATE   Quinoline-4-carboxylate
            Acceptor
            H2O
PRODUCT     Quinolin-2(1H)-one
            Reduced acceptor
COMMENT     Quinoline-4-carboxylate, quinoline, 4-methyl quinoline and 4-
            chloroquinoline will also serve as substrates for the enzyme from
            Agrobacterium sp. 1B.
            1,4-Benzoquinone, iodonitrotetrazolium chloride (INT), thionine,
            menadione and 2,6-dichlorophenolindophenol (DCPIP) will act as
            electron acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.19
            ExPASy - ENZYME nomenclature database: 1.3.99.19
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.19
///
ENTRY       EC 1.3.99.20
NAME        4-Hydroxybenzoyl-CoA reductase
CLASS       Oxidoreductases
            Acting on the CH-CH group of donors
            With other acceptors
SYSNAME     4-Hydroxybenzoyl-CoA:(acceptor) oxidoreductase
REACTION    4-Hydroxybenzoyl-CoA + Acceptor = Benzoyl-CoA + Reduced acceptor
SUBSTRATE   4-Hydroxybenzoyl-CoA
            Acceptor
PRODUCT     Benzoyl-CoA
            Reduced acceptor
COMMENT     Involved in the anaerobic pathway of phenol metabolism in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.3.99.20
            ExPASy - ENZYME nomenclature database: 1.3.99.20
            WIT (What Is There) Metabolic Reconstruction: 1.3.99.20
            UM-BBD (Biocatalysis/Biodegradation Database): 1.3.99.20
///
ENTRY       EC 1.4.1.1
NAME        Alanine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Alanine:NAD+ oxidoreductase (deaminating)
REACTION    L-Alanine + H2O + NAD+ = Pyruvate + NH3 + NADH
SUBSTRATE   L-Alanine
            H2O
            NAD+
PRODUCT     Pyruvate
            NH3
            NADH
PATHWAY     PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       VCH: VC1905
            HPY: HP1398(ald)
            HPJ: jhp1428
            MLO: mll0362 mll9089
            SME: SMc01169(ald)
            CCR: CC3574
            BSU: BG10468(ald)
            BHA: BH2329(ald) BH3180
            SAU: SA1272 SA1531(ald)
            SAV: SAV1428 SAV1695(ald)
            SPR: spr0852(ald-truncation) spr0853(ald-truncation)
                 spr0854(ald-truncation)
            MTU: Rv2780(ald)
            MTC: MT2850
            MLE: ML1532(ald)
            SYN: sll1682
            DRA: DR1895
MOTIF       PS: PS00836  G-[LIVM]-P-x-E-x(3)-N-E-x(1,3)-R-V-A-x-[ST]-P-x-[GST]-
                         V-x(2)-L-x-[KRH]-x-G
            PS: PS00837  [LIVM](2)-G-[GA]-G-x-A-G-x(2)-[SA]-x(3)-[GA]-x-[SG]-
                         [LIVM]-G-A-x-V-x(3)-D
STRUCTURES  PDB: 1SAY  1PJB  1PJC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.1
            ExPASy - ENZYME nomenclature database: 1.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.1
            BRENDA, the Enzyme Database: 1.4.1.1
            SCOP (Structural Classification of Proteins): 1.4.1.1
///
ENTRY       EC 1.4.1.2
NAME        Glutamate dehydrogenase
            Glutamic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate:NAD+ oxidoreductase (deaminating)
REACTION    L-Glutamate + H2O + NAD+ = 2-Oxoglutarate + NH3 + NADH
SUBSTRATE   L-Glutamate
            H2O
            NAD+
PRODUCT     2-Oxoglutarate
            NH3
            NADH
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       NME: NMB1476
            NMA: NMA1687
            BSU: BG10621(rocG) BG11435(ypcA)
            BHA: BH1622 BH2718 BH3942
            SAU: SA0819(gudB)
            SAV: SAV0945
            SCE: YDL215C(GDH2)
            SPO: SPCC132.04C(spcc132.04c)
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL]
STRUCTURES  PDB: 1K89  1HRD  1EUZ  1BGV  1AUP  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.2
            ExPASy - ENZYME nomenclature database: 1.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.2
            BRENDA, the Enzyme Database: 1.4.1.2
            SCOP (Structural Classification of Proteins): 1.4.1.2
///
ENTRY       EC 1.4.1.3
NAME        Glutamate dehydrogenase (NAD(P)+)
            Glutamic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate:NAD(P)+ oxidoreductase (deaminating)
REACTION    L-Glutamate + H2O + NAD+ or NADP+ = 2-Oxoglutarate + NH3 +
            NADH or NADPH
SUBSTRATE   L-Glutamate
            H2O
            NAD+
            NADP+
PRODUCT     2-Oxoglutarate
            NH3
            NADH
            NADPH
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       BHA: BH0824
            DRA: DR0980
            TMA: TM1015
            HAL: VNG0161G(gdhB) VNG0628G(gdhA1) VNG1204G(gdhA2)
            TAC: Ta0635 Ta0776
            TVO: TVG0773051 TVG0774569
            PHO: PH1593
            PAB: PAB0391(gdh)
            APE: APE1386
            SSO: SSO1457(gdhA-1) SSO1907(gdhA-2) SSO1930(gdhA-3)
                 SSO2044(gdhA-4)
            CEL: ZK829.4
            DME: CG4434 CG5320(Gdh)
            MMU: 95753(Glud)
            HSA: 2746(GLUD1) 8307(GLUD2)
DISEASE     MIM: 138130  Glutamate dehydrogenase-1
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL]
STRUCTURES  PDB: 1B26  1HWZ  2TMG  1HWY  1B3B  1BVU  1GTM  1HWX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.3
            ExPASy - ENZYME nomenclature database: 1.4.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.3
            BRENDA, the Enzyme Database: 1.4.1.3
            SCOP (Structural Classification of Proteins): 1.4.1.3
///
ENTRY       EC 1.4.1.4
NAME        Glutamate dehydrogenase (NADP+)
            Glutamic dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate:NADP+ oxidoreductase (deaminating)
REACTION    L-Glutamate + H2O + NADP+ = 2-Oxoglutarate + NH3 + NADPH
SUBSTRATE   L-Glutamate
            H2O
            NADP+
PRODUCT     2-Oxoglutarate
            NH3
            NADPH
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b1761(gdhA)
            ECE: Z2793(gdhA)
            ECS: ECs2467
            YPE: YPO3971(gdhA)
            HIN: HI0189(gdhA)
            PMU: PM0043(gdhA)
            PAE: PA4588(gdhA)
            NME: NMB1710
            NMA: NMA1964(gdhA)
            HPY: HP0380(gdhA)
            HPJ: jhp1001
            SME: SMa0228(gdhA)
            BHA: BH2101(gdhA)
            SPN: SP1306
            SPR: spr1181(gdhA)
            CAC: CAC0737
            SYN: slr0710(gdhA)
            DRA: DR1718
            SCE: YAL062W(GDH3) YOR375C(GDH1)
            SPO: SPCC622.12C(spcc622.12c)
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL]
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.4
            ExPASy - ENZYME nomenclature database: 1.4.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.4
            BRENDA, the Enzyme Database: 1.4.1.4
///
ENTRY       EC 1.4.1.5
NAME        L-Amino-acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Amino-aicd:NAD+ oxidoreductase (deaminating)
REACTION    an L-Amino acid + H2O + NAD+ = a 2-Oxo acid + NH3 + NADH
SUBSTRATE   L-Amino acid
            H2O
            NAD+
PRODUCT     2-Oxo acid
            NH3
            NADH
COMMENT     Acts on aliphatic amino acids.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.5
            ExPASy - ENZYME nomenclature database: 1.4.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.5
            BRENDA, the Enzyme Database: 1.4.1.5
///
ENTRY       EC 1.4.1.6
NAME        Deleted entry
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.4.4.1,
            D-Proline reductase (dithiol).
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.6
            ExPASy - ENZYME nomenclature database: 1.4.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.6
///
ENTRY       EC 1.4.1.7
NAME        Serine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Serine:NAD+ oxidoreductase (deaminating)
REACTION    L-Serine + H2O + NAD+ = 3-Hydroxypyruvate + NH3 + NADH
SUBSTRATE   L-Serine
            H2O
            NAD+
PRODUCT     3-Hydroxypyruvate
            NH3
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.7
            ExPASy - ENZYME nomenclature database: 1.4.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.7
            BRENDA, the Enzyme Database: 1.4.1.7
///
ENTRY       EC 1.4.1.8
NAME        Valine dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Valine:NADP+ oxidoreductase (deaminating)
REACTION    L-Valine + H2O + NADP+ = 3-Methyl-2-oxobutanoate + NH3 + NADPH
SUBSTRATE   L-Valine
            H2O
            NADP+
PRODUCT     3-Methyl-2-oxobutanoate
            NH3
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.8
            ExPASy - ENZYME nomenclature database: 1.4.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.8
            BRENDA, the Enzyme Database: 1.4.1.8
///
ENTRY       EC 1.4.1.9
NAME        Leucine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Leucine:NAD+ oxidoreductase(deaminating)
REACTION    L-Leucine + H2O + NAD+ = 4-Methyl-2-oxopentanoate + NH3 + NADH
SUBSTRATE   L-Leucine
            H2O
            NAD+
            L-Isoleucine
            L-Valine
            L-Norvaline
            L-Norleucine
PRODUCT     4-Methyl-2-oxopentanoate
            NH3
            NADH
            3-Methyl-2-oxopentanoate
            3-Methyl-2-oxobutanoate
            2-Oxopentanoate
            2-Oxohexanoate
COMMENT     Also acts on isoleucine, valine, norvaline and norleucine.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
GENES       PAE: PA3418(ldh)
            CCR: CC2082
            BSU: BG11723(bcd)
            BHA: BH2765
            CTR: CT773
            CPN: CPn0919
            CPA: CP0947
            CPJ: ldh
            DRA: DR0158
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL]
STRUCTURES  PDB: 1LEH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.9
            ExPASy - ENZYME nomenclature database: 1.4.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.9
            BRENDA, the Enzyme Database: 1.4.1.9
            SCOP (Structural Classification of Proteins): 1.4.1.9
///
ENTRY       EC 1.4.1.10
NAME        Glycine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Glycine:NAD+ oxidoreductase (deaminating)
REACTION    Glycine + H2O + NAD+ = Glyoxylate + NH3 + NADH
SUBSTRATE   Glycine
            H2O
            NAD+
PRODUCT     Glyoxylate
            NH3
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.10
            ExPASy - ENZYME nomenclature database: 1.4.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.10
            BRENDA, the Enzyme Database: 1.4.1.10
///
ENTRY       EC 1.4.1.11
NAME        L-erythro-3,5-Diaminohexanoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-erythro-3,5-Diaminohexanoate:NAD+ oxidoreductase (deaminating)
REACTION    L-erythro-3,5-Diaminohexanoate + H2O + NAD+ =
            (S)-5-Amino-3-oxohexanoate + NH3 + NADH
SUBSTRATE   L-erythro-3,5-Diaminohexanoate
            H2O
            NAD+
PRODUCT     (S)-5-Amino-3-oxohexanoate
            NH3
            NADH
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.11
            ExPASy - ENZYME nomenclature database: 1.4.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.11
            BRENDA, the Enzyme Database: 1.4.1.11
///
ENTRY       EC 1.4.1.12
NAME        2,4-Diaminopentanoate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,4-Diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)
REACTION    2,4-Diaminopentanoate + H2O + NAD+ or NADP+ =
            2-Amino-4-oxopentanoate + NH3 + NADH or NADPH
SUBSTRATE   2,4-Diaminopentanoate
            H2O
            NAD+
            NADP+
PRODUCT     2-Amino-4-oxopentanoate
            NH3
            NADH
            NADPH
COMMENT     Also acts, more slowly, on 2,5-diaminohexanoate forming 2-amino-
            -5-oxohexanoate, which then cyclizes non-enzymically to
            1-pyrroline-2-methyl-5-carboxylate.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.12
            ExPASy - ENZYME nomenclature database: 1.4.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.12
            BRENDA, the Enzyme Database: 1.4.1.12
///
ENTRY       EC 1.4.1.13
NAME        Glutamate synthase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate:NADP+ oxidoreductase (transaminating)
REACTION    2 L-Glutamate + NADP+ = L-Glutamine + 2-Oxoglutarate + NADPH
SUBSTRATE   L-Glutamate
            NADP+
PRODUCT     2-Oxoglutarate
            L-Glutamine
            NADPH
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     An iron-sulfur flavoprotein. In the reverse reaction ammonia can
            act instead of glutamine, but more slowly. Formerly EC 2.6.1.53.
            Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b3212(gltB) b3213(gltD)
            ECE: Z4576(gltB) Z4577(gltD)
            ECS: ECs4091 ECs4092
            YPE: YPO3557(gltB) YPO3558(gltD)
            XFA: XF2709 XF2710
            VCH: VC2373 VC2374 VC2376 VC2377
            PAE: PA0440 PA5035(gltD) PA5036(gltB)
            CJE: Cj0007(gltB) Cj0009(gltD)
            MLO: mll1646 mll3029
            SME: SMc01814 SMc04026(gltD) SMc04028(gltB)
            CCR: CC3606 CC3607
            BSU: BG10811(gltA) BG12594(gltB) BG12832(yerD)
            BHA: BH1728(gltA) BH1729(gltB)
            SAU: SA0430(gltB) SA0431(gltD) SA2248
            SAV: SAV0459(gltA) SAV0460(gltB)
            LLA: L0119(gltB) L114827(gltD)
            CAC: CAC0764 CAC1673(gltA) CAC1674(gltB)
            MTU: Rv3858c(gltD) Rv3859c(gltB)
            MTC: MT3973 MT3974
            MLE: ML0061(gltB) ML0062(gltD)
            TPA: TP0735
            DRA: DR0182 DR0183
            AAE: aq_1565(gltB) aq_2064(gltD)
            TMA: TM0397 TM1217 TM1640
            MJA: MJ1351(gltB)
            MTH: MTH105 MTH1666 MTH194
            AFU: AF0953(gltB)
            TAC: Ta0414
            TVO: TVG1211894
            PHO: PH0876 PH1873
            PAB: PAB1214 PAB1738
            APE: APE0935
            SSO: SSO0684(gltB)
            SCE: YDL171C(GLT1)
            CEL: W07E11.1
            DME: CG9674 CG9674_1
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.13
            ExPASy - ENZYME nomenclature database: 1.4.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.13
            BRENDA, the Enzyme Database: 1.4.1.13
///
ENTRY       EC 1.4.1.14
NAME        Glutamate synthase (NADH)
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Glutamate:NAD+ oxidoreductase (transaminating)
REACTION    2 L-Glutamate + NAD+ = L-Glutamine + 2-Oxoglutarate + NADH
SUBSTRATE   L-Glutamate
            NAD+
PRODUCT     L-Glutamine
            2-Oxoglutarate
            NADH
COFACTOR    FMN
COMMENT     A flavoprotein (FMN).
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       SYN: sll1027(gltD)
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.14
            ExPASy - ENZYME nomenclature database: 1.4.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.14
            BRENDA, the Enzyme Database: 1.4.1.14
///
ENTRY       EC 1.4.1.15
NAME        Lysine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Lysine:NAD+ oxidoreductase (deaminating, cyclizing)
REACTION    L-Lysine + NAD+ = 1,2-Didehydropiperidine-2-carboxylate + NH3 +
            NADH
SUBSTRATE   L-Lysine
            NAD+
PRODUCT     1,2-Didehydropiperidine-2-carboxylate
            NH3
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.15
            ExPASy - ENZYME nomenclature database: 1.4.1.15
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.15
            BRENDA, the Enzyme Database: 1.4.1.15
///
ENTRY       EC 1.4.1.16
NAME        Diaminopimelate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     meso-2,6-Diaminoheptanedioate:NADP+ oxidoreductase (deaminating)
REACTION    meso-2,6-Diaminoheptanedioate + H2O + NADP+ =
            L-2-Amino-6-oxoheptanedioate + NH3 + NADPH
SUBSTRATE   meso-2,6-Diaminoheptanedioate
            H2O
            NADP+
PRODUCT     L-2-Amino-6-oxoheptanedioate
            NH3
            NADPH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
STRUCTURES  PDB: 2DAP  1F06  1DAP  3DAP  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.16
            ExPASy - ENZYME nomenclature database: 1.4.1.16
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.16
            BRENDA, the Enzyme Database: 1.4.1.16
            SCOP (Structural Classification of Proteins): 1.4.1.16
///
ENTRY       EC 1.4.1.17
NAME        N-Methylalanine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-Methyl-L-alanine:NADP+ oxidoreductase (demethylating,
            $ deaminating)
REACTION    N-Methyl-L-alanine + H2O + NADP+ = Pyruvate + Methylamine + NADPH
SUBSTRATE   N-Methyl-L-alanine
            H2O
            NADP+
PRODUCT     Pyruvate
            Methylamine
            NADPH
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.17
            ExPASy - ENZYME nomenclature database: 1.4.1.17
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.17
            BRENDA, the Enzyme Database: 1.4.1.17
///
ENTRY       EC 1.4.1.18
NAME        Lysine 6-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Lysine:NAD+ 6-oxidoreductase (deaminating)
REACTION    L-Lysine + NAD+ = Allysine + NADH
SUBSTRATE   L-Lysine
            NAD+
PRODUCT     Allysine
            NADH
COMMENT     The product is spontaneously converted into 1,6-didehydro-
            piperidine-2-carboxylate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.18
            ExPASy - ENZYME nomenclature database: 1.4.1.18
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.18
            BRENDA, the Enzyme Database: 1.4.1.18
///
ENTRY       EC 1.4.1.19
NAME        Tryptophan dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Tryptophan:NAD(P)+ oxidoreductase (deaminating)
REACTION    L-Tryptophan + NAD+ or NADP+ = (Indol-3-yl)pyruvate + NH3 +
            NADH or NADPH
SUBSTRATE   L-Tryptophan
            NAD+
            NADP+
PRODUCT     (Indol-3-yl)pyruvate
            NH3
            NADH
            NADPH
EFFECTOR    Calcium
COMMENT     Activated by Ca2+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.19
            ExPASy - ENZYME nomenclature database: 1.4.1.19
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.19
            BRENDA, the Enzyme Database: 1.4.1.19
///
ENTRY       EC 1.4.1.20
NAME        Phenylalanine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Phenylalanine:NAD+ oxidoreductase (deaminating)
REACTION    L-Phenylalanine + H2O + NAD+ = Phenylpyruvate + NH3 + NADH
SUBSTRATE   L-Phenylalanine
            H2O
            NAD+
            L-Tyrosine
PRODUCT     Phenylpyruvate
            NH3
            NADH
COMMENT     The enzymes from Bacillus badius and Sporosarcina ureae are
            highly specific for L-phenylalanine; that from Bacillus
            sphaericus also acts on L-tyrosine.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
MOTIF       PS: PS00074  [LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL]
STRUCTURES  PDB: 1BXG  1BW9  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.1.20
            ExPASy - ENZYME nomenclature database: 1.4.1.20
            WIT (What Is There) Metabolic Reconstruction: 1.4.1.20
            BRENDA, the Enzyme Database: 1.4.1.20
            SCOP (Structural Classification of Proteins): 1.4.1.20
///
ENTRY       EC 1.4.2.1
NAME        Glycine dehydrogenase (cytochrome)
            Glycine--cytochrome c reductase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With a cytochrome as acceptor
SYSNAME     Glycine:ferricytochrome-c oxidoreductase (deaminating)
REACTION    Glycine + H2O + 2 Ferricytochrome c = Glyoxylate + NH3 +
            2 Ferrocytochrome c
SUBSTRATE   Glycine
            H2O
            Ferricytochrome c
PRODUCT     Glyoxylate
            NH3
            Ferrocytochrome c
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.2.1
            ExPASy - ENZYME nomenclature database: 1.4.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.2.1
            BRENDA, the Enzyme Database: 1.4.2.1
///
ENTRY       EC 1.4.3.1
NAME        D-Aspartate oxidase
            Aspartate oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     D-Aspartate:oxygen oxidoreductase (deaminating)
REACTION    D-Aspartate + H2O + O2 = Oxaloacetate + NH3 + H2O2
SUBSTRATE   D-Aspartate
            H2O
            O2
PRODUCT     Oxaloacetate
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
GENES       HSA: 8528(DDO)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00677  [LIVM](2)-H-[NHA]-Y-G-x-[GSA](2)-x-G-x(5)-G-x-A
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.1
            ExPASy - ENZYME nomenclature database: 1.4.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.1
            BRENDA, the Enzyme Database: 1.4.3.1
///
ENTRY       EC 1.4.3.2
NAME        L-Amino-acid oxidase
            Ophio-amino-acid oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     L-Amino-acid:oxygen oxidoreductase (deaminating)
REACTION    L-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2
SUBSTRATE   L-Amino acid
            H2O
            O2
PRODUCT     2-Oxo acid
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00271  Methionine metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00950  Alkaloid biosynthesis I
STRUCTURES  PDB: 1F8R  1F8S  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.2
            ExPASy - ENZYME nomenclature database: 1.4.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.2
            BRENDA, the Enzyme Database: 1.4.3.2
            SCOP (Structural Classification of Proteins): 1.4.3.2
///
ENTRY       EC 1.4.3.3
NAME        D-Amino-acid oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     D-Amino-acid:oxygen oxidoreductase (deaminating)
REACTION    D-Amino acid + H2O + O2 = 2-Oxo acid + NH3 + H2O2
SUBSTRATE   D-Amino acid
            Glycine
            H2O
            O2
PRODUCT     2-Oxo acid
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
            Wide specificity for D-amino acids. Also acts on glycine.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
GENES       CEL: C47A10.5
            MMU: 94859(Dao1)
            HSA: 1610(DAO)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00677  [LIVM](2)-H-[NHA]-Y-G-x-[GSA](2)-x-G-x(5)-G-x-A
STRUCTURES  PDB: 1KIF  1AA8  1AN9  1C0K  1C0P  1DAO  1DDO  1EVI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.3
            ExPASy - ENZYME nomenclature database: 1.4.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.3
            BRENDA, the Enzyme Database: 1.4.3.3
            SCOP (Structural Classification of Proteins): 1.4.3.3
///
ENTRY       EC 1.4.3.4
NAME        Amine oxidase (flavin-containing)
            Monoamine oxidase
            Tyramine oxidase
            Tyraminase
            Amine oxidase
            Adrenalin oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Amine:oxygen oxidoreductase(deaminating)(flavin-containing)
REACTION    RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2
SUBSTRATE   RCH2NH2
            H2O
            O2
            Primary amine
            Secondary amine
            Tertiary amine
PRODUCT     RCHO
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein(FAD). Acts on primary amines, and usually also
            on some secondary and tertiary amines.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
GENES       MLO: mll3668
            SME: SMb21110
            HSA: 4128(MAOA) 4129(MAOB)
DISEASE     MIM: 309850  Monoamine oxidase A
            MIM: 309860  Monoamine oxidase B
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1DYU  1H8Q  1H8R  1QAF  1QAK  1QAL  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.4
            ExPASy - ENZYME nomenclature database: 1.4.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.4
            BRENDA, the Enzyme Database: 1.4.3.4
            SCOP (Structural Classification of Proteins): 1.4.3.4
///
ENTRY       EC 1.4.3.5
NAME        Pyridoxamine-phosphate oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)
REACTION    Pyridoxamine 5'-phosphate + H2O + O2 = Pyridoxal 5'-phosphate +
            NH3 + H2O2
SUBSTRATE   Pyridoxamine 5'-phosphate
            H2O
            O2
            Pyridoxine 5'-phosphate
            Pyridoxine
PRODUCT     Pyridoxal 5'-phosphate
            NH3
            H2O2
COFACTOR    FMN
COMMENT     A flavoprotein (FMN). Also oxidizes pyridoxine 5-phosphate and
            pyridoxine.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
GENES       ECO: b1638(pdxH)
            ECE: Z2652(pdxH)
            ECS: ECs2347
            YPE: YPO2370(pdxH)
            HIN: HI0863(pdxH)
            XFA: XF1337
            VCH: VCA1079
            PAE: PA1049(pdxH)
            NME: NMB1360
            NMA: NMA1572(pdxH)
            MLO: mll7454
            SME: SMc00069(pdxH)
            CCR: CC0918
            MTU: Rv2607(pdxH)
            MTC: MT2682
            MLE: ML2131(pdxH)
            SYN: sll1440(pdxH)
            DRA: DR0495
            SCE: YBR035C(PDX3)
            SPO: SPAC1093.02(spac1093.02)
            CEL: F57B9.1
MOTIF       PS: PS01064  [LIVF]-E-F-W-[QHG]-x(4)-R-[LIVM]-H-[DNE]-R
STRUCTURES  PDB: 1G79  1CI0  1DNL  1G76  1G77  1G78  1JNW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.5
            ExPASy - ENZYME nomenclature database: 1.4.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.5
            BRENDA, the Enzyme Database: 1.4.3.5
            SCOP (Structural Classification of Proteins): 1.4.3.5
///
ENTRY       EC 1.4.3.6
NAME        Amine oxidase (copper-containing)
            Diamine oxidase
            Diamino oxhydrase
            Histaminase
            Amine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Amine:oxygen oxidoreductase (deaminating) (copper-containing)
REACTION    RCH2NH2 + H2O = RCHO + NH3 + H2O2
SUBSTRATE   RCH2NH2
            H2O
            Primary monoamine
            Primary diamine
            Histamine
PRODUCT     RCHO
            NH3
            H2O2
COFACTOR    Copper
            PQQ
COMMENT     A group of enzymes including those oxidizing primary monoamines,
            diamines and histamine. They are copper quinoproteins.  One form
            of EC 1.3.1.15 from rat kidney also catalyses this reaction.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00960  Alkaloid biosynthesis II
GENES       ECO: b1386(tynA)
            MLO: mll6250
            SSO: SSO1692(tynA)
            HSA: 26(ABP1) 314(AOC2) 8639(AOC3)
DISEASE     MIM: 104610  Amiloride-binding protein-1
            MIM: 602268  Amine oxidase, copper-containing, 2
            MIM: 603735  Amine oxidase, copper-containing 3
MOTIF       PS: PS01164  [LIVM]-[LIVMA]-[LIVMF]-x(4)-[ST]-x(2)-N-Y-[DE]-[YN]
            PS: PS01165  T-x-[GS]-x(2)-H-[LIVMF]-x(3)-E-[DE]-x-P
STRUCTURES  PDB: 1A2V  1SPU  1AV4  1AVK  1AVL  1D6U  1D6Y  1D6Z  1EKM  1KSI  
                 1OAC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.6
            ExPASy - ENZYME nomenclature database: 1.4.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.6
            BRENDA, the Enzyme Database: 1.4.3.6
            SCOP (Structural Classification of Proteins): 1.4.3.6
///
ENTRY       EC 1.4.3.7
NAME        D-Glutamate oxidase
            D-Glutamic oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     D-Glutamate:oxygen oxidoreductase (deaminating)
REACTION    D-Glutamate + H2O + O2 = 2-Oxoglutarate + NH3 + H2O2
SUBSTRATE   D-Glutamate
            H2O
            O2
PRODUCT     2-Oxoglutarate
            NH3
            H2O2
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.7
            ExPASy - ENZYME nomenclature database: 1.4.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.7
            BRENDA, the Enzyme Database: 1.4.3.7
///
ENTRY       EC 1.4.3.8
NAME        Ethanolamine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Ethanolamine:oxygen oxidoreductase (deaminating)
REACTION    Ethanolamine + H2O + O2 = Glycolaldehyde + NH3 + H2O2
SUBSTRATE   Ethanolamine
            H2O
            O2
PRODUCT     Glycolaldehyde
            NH3
            H2O2
COFACTOR    Cobamide
COMMENT     A cobamide-protein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.8
            ExPASy - ENZYME nomenclature database: 1.4.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.8
            BRENDA, the Enzyme Database: 1.4.3.8
///
ENTRY       EC 1.4.3.9
NAME        Deleted entry
            Tyramine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
COMMENT     Deleted entry. Now included with EC 1.4.3.4.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.9
            ExPASy - ENZYME nomenclature database: 1.4.3.9
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.9
///
ENTRY       EC 1.4.3.10
NAME        Putrescine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Putrescine:oxygen oxidoreductase (deaminating)
REACTION    Putrescine + O2 + H2O = 4-Aminobutanal + NH3 + H2O2
SUBSTRATE   Putrescine
            O2
            H2O
PRODUCT     4-Aminobutanal
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  4-Aminobutanal condenses non-enzymically
            to 1-pyrroline.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.10
            ExPASy - ENZYME nomenclature database: 1.4.3.10
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.10
            BRENDA, the Enzyme Database: 1.4.3.10
///
ENTRY       EC 1.4.3.11
NAME        L-Glutamate oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     L-Glutamate:oxygen oxidoreductase (deaminating)
REACTION    L-Glutamate + O2 + H2O = 2-Oxoglutarate + NH3 + H2O2
SUBSTRATE   L-Glutamate
            O2
            H2O
PRODUCT     2-Oxoglutarate
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD.)  The enzyme from Azotobacter previously
            listed under this number. which did not produce H2O2, was a crude
            cell-free extract which probably contained catalase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.11
            ExPASy - ENZYME nomenclature database: 1.4.3.11
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.11
            BRENDA, the Enzyme Database: 1.4.3.11
///
ENTRY       EC 1.4.3.12
NAME        Cyclohexylamine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Cyclohexylamine:oxygen oxidoreductase (deaminating)
REACTION    Cyclohexylamine + O2 + H2O = Cyclohexanone + NH3 + H2O2
SUBSTRATE   Cyclohexylamine
            O2
            H2O
PRODUCT     Cyclohexanone
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Some other cyclic amines can act instead
            of cyclohexylamine, but not simple aliphatic and aromatic amides.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.12
            ExPASy - ENZYME nomenclature database: 1.4.3.12
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.12
            UM-BBD (Biocatalysis/Biodegradation Database): 1.4.3.12
            BRENDA, the Enzyme Database: 1.4.3.12
///
ENTRY       EC 1.4.3.13
NAME        Protein-lysine 6-oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     Protein-L-lysine:oxygen 6-oxidoreductase (deaminating)
REACTION    Peptidyl-L-lysyl-peptide + H2O + O2 =
            Peptidyl-allysyl-peptide + NH3 + H2O2
SUBSTRATE   Peptidyl-L-lysyl-peptide
            H2O
            O2
            Protein 5-hydroxylysine
PRODUCT     Peptidyl-allysyl-peptide
            NH3
            H2O2
COMMENT     Also acts on protein 5-hydroxylysine.
GENES       MMU: 96817(Lox)
            HSA: 4015(LOX)
DISEASE     MIM: 153455  Lysyl oxidase
MOTIF       PS: PS00926  W-x-W-H-x-C-H-x-H-Y-H-S-M-[DE]
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.13
            ExPASy - ENZYME nomenclature database: 1.4.3.13
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.13
            BRENDA, the Enzyme Database: 1.4.3.13
///
ENTRY       EC 1.4.3.14
NAME        L-Lysine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     L-Lysine:oxygen oxidoreductase(deaminating)
REACTION    L-Lysine + O2 + H2O = 6-Amino-2-oxohexanoate + NH3 + H2O2
SUBSTRATE   L-Lysine
            O2
            H2O
            L-Ornithine
            L-Phenylalanine
            L-Arginine
            L-Histidine
PRODUCT     6-Amino-2-oxohexanoate
            NH3
            H2O2
            5-Amino-2-oxopentanoate
            3-Phenyl-2-oxopropanoate
            5-Guanidino-2-oxopentanoate
            3-Imidazole-2-oxopropanoate
COMMENT     Also acts, more slowly, on L-ornithine, L-phenylalanine,
            L-arginine, and L-histidine.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.14
            ExPASy - ENZYME nomenclature database: 1.4.3.14
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.14
            BRENDA, the Enzyme Database: 1.4.3.14
///
ENTRY       EC 1.4.3.15
NAME        D-Glutamate(D-aspartate) oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     D-Glutamate(D-aspartate):oxygen oxidoreductase (deaminating)
REACTION    D-Glutamate + H2O + O2 = 2-Oxoglutarate + NH3 + H2O2
SUBSTRATE   D-Glutamate
            H2O
            O2
            D-Aspartate
PRODUCT     2-Oxoglutarate
            NH3
            H2O2
            Oxaloacetate
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  D-Glutamate and D-aspartate are oxidized
            at the same rate.  Other D-monoaminodicarboxylates, and other
            D- and L-amino acids, are not oxidized.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.15
            ExPASy - ENZYME nomenclature database: 1.4.3.15
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.15
            BRENDA, the Enzyme Database: 1.4.3.15
///
ENTRY       EC 1.4.3.16
NAME        L-Aspartate oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     L-Aspartate:oxygen oxidoreductase (deaminating)
REACTION    L-Aspartate + H2O + O2 = Oxaloacetate + NH3 + H2O2
SUBSTRATE   L-Aspartate
            H2O
            O2
PRODUCT     Oxaloacetate
            NH3
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). A component of the bacterial quinolinate
            synthase system.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
GENES       ECO: b2574(nadB)
            ECE: Z3856(nadB)
            ECS: ECs3440
            YPE: YPO2710(nadB)
            XFA: XF1924
            VCH: VC2469
            PAE: PA0761(nadB)
            NME: NMB0392
            NMA: NMA2092(nadB)
            MLO: mll5834 mll9103
            SME: SMc02599(nadB)
            CCR: CC2913
            BSU: BG10867(nadB)
            BHA: BH1218(nadB)
            CAC: CAC1024(nadB)
            MTU: Rv1595(nadB)
            MTC: MT1631
            MLE: ML1226(nadB)
            SYN: sll0631(nadB)
            AAE: aq_777(nadB)
            HAL: VNG1883G(nadB)
            PHO: PH0015
            PAB: PAB2343
            SSO: SSO0997(nadB)
            STO: ST1196
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.16
            ExPASy - ENZYME nomenclature database: 1.4.3.16
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.16
            BRENDA, the Enzyme Database: 1.4.3.16
///
ENTRY       EC 1.4.3.17
NAME        Tryptophan alpha,beta-oxidase
            L-Tryptophan alpha,beta-dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With oxygen as acceptor
SYSNAME     L-Tryptophan:oxygen alpha,beta-oxidoreductase
REACTION    L-Tryptophan + O2 = alpha,beta-Didehydrotryptophan + H2O2
SUBSTRATE   L-Tryptophan
            O2
PRODUCT     alpha,beta-Didehydrotryptophan
            H2O2
COFACTOR    Heme
COMMENT     Requires heme. The enzyme from Chromobacterium violaceum is
            specific for tryptophan derivatives possessing its carboxyl group
            free or as an amide or ester, and an unsubstituted indole ring.
            Also catalyses the alpha,beta dehydrogenation of L-tryptophan side
            chains in peptides.
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.3.17
            ExPASy - ENZYME nomenclature database: 1.4.3.17
            WIT (What Is There) Metabolic Reconstruction: 1.4.3.17
///
ENTRY       EC 1.4.4.1
NAME        D-Proline reductase (dithiol)
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With a disulfide as acceptor
SYSNAME     5-Aminopentanoate:lipoate oxidoreductase (cyclizing)
REACTION    5-Aminopentanoate + Lipoate = D-Proline + Dihydrolipoate
SUBSTRATE   5-Aminopentanoate
            Lipoate
PRODUCT     D-Proline
            Dihydrolipoate
COFACTOR    Pyruvate
COMMENT     Other dithiols can function as reducing agents; the enzyme
            contains bound pyruvate which acts as a cofactor.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.4.1
            ExPASy - ENZYME nomenclature database: 1.4.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.4.1
            BRENDA, the Enzyme Database: 1.4.4.1
///
ENTRY       EC 1.4.4.2
NAME        Glycine dehydrogenase (decarboxylating)
            Glycine decarboxylase
            P-Protein
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With a disulfide as acceptor
SYSNAME     Glycine:lipoylprotein oxidoreductase (decarboxylating and
            acceptor-aminomethylating)
REACTION    Glycine + Lipoylprotein = S-Aminomethyldihydrolipoylprotein +
            CO2
SUBSTRATE   Glycine
            Lipoylprotein
            Lipoamide
PRODUCT     S-Aminomethyldihydrolipoylprotein
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Lipoamide can also act as
            acceptor. A component, with EC 2.1.2.10, of the glycine
            cleavage system, previously known as glycine synthase.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b2903(gcvP)
            ECE: Z4240(gcvP)
            ECS: ECs3774
            YPE: YPO0905(gcvP)
            XFA: XF1385
            PAE: PA2445(gcvP2) PA5213(gcvP1)
            NMA: NMA1934(gcvP)
            MLO: mlr0885
            SME: SMc02049(gcvP)
            CCR: CC3352 CC3353
            BSU: BG11510(gcvPA) BG11511(gcvPB)
            BHA: BH2814 BH2815
            SAU: SA1365 SA1366
            SAV: SAV1524 SAV1525
            MTU: Rv1832(gcvB)
            MTC: MT1880
            MLE: ML2072(gcvB)
            SYN: slr0293(gcvP)
            DRA: DR1809
            AAE: aq_1109(gcsP2) aq_1903(gcsP1)
            TMA: TM0213 TM0214
            HAL: VNG1601G(gcvP2) VNG1603G(gcvP1)
            TAC: Ta1357 Ta1358
            TVO: TVG0309943 TVG0311358
            PHO: PH1994 PH1995
            PAB: PAB1171 PAB1172
            APE: APE2121 APE2124
            SSO: SSO0917 SSO0918
            STO: ST1207 ST1208
            SCE: YMR189W(GCV2)
            SPO: SPAC13G6.06C(spac13g6.06c)
            ATH: At2g26080(T19L18.11)
            CEL: R12C12.1
            DME: CG3999
            HSA: 2731(GLDC)
DISEASE     MIM: 238300  Glycine dehydrogenase (decarboxylating; glycine
                         decarboxylase, glycine
STRUCTURES  PDB: 1HTP  1HPC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.4.2
            ExPASy - ENZYME nomenclature database: 1.4.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.4.4.2
            BRENDA, the Enzyme Database: 1.4.4.2
            SCOP (Structural Classification of Proteins): 1.4.4.2
///
ENTRY       EC 1.4.7.1
NAME        Glutamate synthase (ferredoxin)
            Ferredoxin-dependent glutamate synthase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     L-Glutamate:ferredoxin oxidoreductase (transaminating)
REACTION    2 L-Glutamate + 2 Oxidized ferredoxin =
            L-Glutamine + 2-Oxoglutarate + 2 Reduced ferredoxin
SUBSTRATE   L-Glutamate
            Oxidized ferredoxin
PRODUCT     L-Glutamine
            2-Oxoglutarate
            Reduced ferredoxin
COFACTOR    Iron
            Sulfur
            FAD
COMMENT     An iron-sulfur flavoprotein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       SYN: sll1499(gltS) sll1502(gltB)
            MTH: MTH1819 MTH400
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.7.1
            ExPASy - ENZYME nomenclature database: 1.4.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.7.1
            BRENDA, the Enzyme Database: 1.4.7.1
///
ENTRY       EC 1.4.99.1
NAME        D-Amino-acid dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With other acceptors
SYSNAME     D-Amino-acid:(acceptor) oxidoreductase (deaminating)
REACTION    a D-Amino acid + H2O + Acceptor = a 2-Oxo acid + NH3 +
            Reduced acceptor
SUBSTRATE   D-Amino acid
            H2O
            Acceptor
PRODUCT     2-Oxo acid
            NH3
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Acts to some extent on all D-amino acids
            except D-aspartate and D-glutamate.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b1189(dadA)
            ECE: Z1952(dadA)
            ECS: ECs1684
            YPE: YPO2147(dadA)
            XFA: XF0851
            VCH: VC0786
            PAE: PA5304(dadA)
            NME: NMB0176
            NMA: NMA0092(dadA)
            HPY: HP0943(dadA)
            HPJ: jhp0878
            MLO: mll3992 mll6285
            SME: SMb20267 SMc03265
STRUCTURES  PDB: 1FE2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.99.1
            ExPASy - ENZYME nomenclature database: 1.4.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.4.99.1
            BRENDA, the Enzyme Database: 1.4.99.1
///
ENTRY       EC 1.4.99.2
NAME        Taurine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With other acceptors
SYSNAME     Taurine:(acceptor) oxidoreductase (deaminating)
REACTION    Taurine + H2O + Acceptor = Sulfoacetaldehyde + NH3 +
            Reduced acceptor
SUBSTRATE   Taurine
            H2O
            Acceptor
PRODUCT     Sulfoacetaldehyde
            NH3
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.99.2
            ExPASy - ENZYME nomenclature database: 1.4.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.4.99.2
            BRENDA, the Enzyme Database: 1.4.99.2
///
ENTRY       EC 1.4.99.3
NAME        Amine dehydrogenase
            Methylamine dehydrogenase
            Primary-amine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With other acceptors
SYSNAME     Primary-amine:(acceptor) oxidoreductase (deaminating)
REACTION    RCH2NH2 + H2O + Acceptor = RCHO + NH3 + Reduced acceptor
SUBSTRATE   RCH2NH2
            Primary amine
            H2O
            Acceptor
PRODUCT     RCHO
            Aldehyde
            NH3
            Reduced acceptor
COFACTOR    PQQ
COMMENT     A quinoprotein.
PATHWAY     PATH: MAP00680  Methane metabolism
STRUCTURES  PDB: 2BBK  1MAE  1MAF  1MDA  2MTA  2MAD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.99.3
            ExPASy - ENZYME nomenclature database: 1.4.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.4.99.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.4.99.3
            BRENDA, the Enzyme Database: 1.4.99.3
            SCOP (Structural Classification of Proteins): 1.4.99.3
///
ENTRY       EC 1.4.99.4
NAME        Aralkylamine dehydrogenase
            Aromatic amine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH2 group of donors
            With other acceptors
SYSNAME     Aralkylamine:(acceptor) oxidoreductase (deaminating)
REACTION    RCH2NH2 + H2O + Acceptor = RCHO + NH3 + Reduced acceptor
SUBSTRATE   RCH2NH2
            H2O
            Acceptor
            Phenazine methosulfate
PRODUCT     RCHO
            NH3
            Reduced acceptor
COMMENT     Phenazine methosulfate can act as acceptor.  Acts on aromatic
            amines and, more slowly, on some long-chain aliphatic amines,
            but not methylamine or ethylamine (cf. EC 1.4.99.3).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.4.99.4
            ExPASy - ENZYME nomenclature database: 1.4.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.4.99.4
            BRENDA, the Enzyme Database: 1.4.99.4
///
ENTRY       EC 1.5.1.1
NAME        Pyrroline-2-carboxylate reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Proline:NAD(P)+ 2-oxidoreductase
REACTION    L-Proline + NAD+ or NADP+ = 1-Pyrroline-2-carboxylate +
            NADH or NADPH
SUBSTRATE   L-Proline
            NAD+
            NADP+
            L-Pipecolate
PRODUCT     1-Pyrroline-2-carboxylate
            NADH
            NADPH
            1,2-Didehydropiperidine-2-carboxylate
COMMENT     Reduces 1-pyrroline-2-carboxylate to L-proline and also
            1,2-didehydropiperidine-2-carboxylate to L-pipecolate.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.1
            ExPASy - ENZYME nomenclature database: 1.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.1
            BRENDA, the Enzyme Database: 1.5.1.1
///
ENTRY       EC 1.5.1.2
NAME        Pyrroline-5-carboxylate reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Proline:NAD(P)+ 5-oxidoreductase
REACTION    L-Proline + NAD+ or NADP+ = L-1-Pyrroline-5-carboxylate +
            NADH or NADPH
SUBSTRATE   L-Proline
            L-1-Pyrroline-3-hydroxy-5-carboxylate
            NAD+
            NADP+
PRODUCT     L-1-Pyrroline-5-carboxylate
            NADH
            NADPH
            L-Hydroxyproline
COMMENT     Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to
            L-hydroxyproline.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b0386(proC)
            ECE: Z0482(proC)
            ECS: ECs0437
            YPE: YPO0942(proC)
            HIN: HI0307(proC)
            PMU: PM0095(proC)
            XFA: XF2712
            VCH: VC0460
            PAE: PA0393(proC)
            NME: NMB0055
            NMA: NMA0215(proC)
            HPY: HP1158(proC)
            HPJ: jhp1085
            CJE: Cj1076(proC)
            MLO: mll6498
            SME: SMc02677(proC)
            CCR: CC0494
            BSU: BG10841(proG) BG11049(proH) BG11744(yqjO)
            BHA: BH0887 BH1503
            SAU: SA1334
            SAV: SAV1492
            LLA: L135991(proC)
            SPY: SPy0112(proC)
            SPN: SP0933
            SPR: spr0834(proC)
            CAC: CAC3252(proC)
            MTU: Rv0500(proC)
            MTC: MT0520
            MLE: ML2430(proC)
            TPA: TP0797
            SYN: slr0661(proC)
            DRA: DR1522
            AAE: aq_166(proC)
            TMA: TM0578
            MTH: MTH897
            TAC: Ta0139
            TVO: TVG1190495
            APE: APE0146
            SSO: SSO0495(proC)
            STO: ST0646
            SCE: YER023W(PRO3)
            SPO: SPAPYUG7.05(spapyug7.05)
            ATH: At5g14800(T9L3.100)
            CEL: F55G1.9 M153.1
            DME: CG5840 CG6009(P5cr)
            HSA: 5831(PYCR1)
DISEASE     MIM: 179035  Pyroline-5-carboxylate reductase-1
MOTIF       PS: PS00521  [PALF]-x(2,3)-[LIV]-x(3)-[LIVM]-[STAC]-[STV]-x-[GAN]-G-
                         x-T-x(2)-[AG]-[LIV]-x(2)-[LMF]-[DENQK]
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.2
            ExPASy - ENZYME nomenclature database: 1.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.2
            BRENDA, the Enzyme Database: 1.5.1.2
///
ENTRY       EC 1.5.1.3
NAME        Dihydrofolate reductase
            Tetrahydrofolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
REACTION    5,6,7,8-Tetrahydrofolate + NADP+ = 7,8-Dihydrofolate + NADPH
SUBSTRATE   5,6,7,8-Tetrahydrofolate
            Folate
            NADP+
PRODUCT     7,8-Dihydrofolate
            NADPH
INHIBITOR   Trimethoprim
            Methotrexate
COMMENT     The enzyme from animals and some micro-organisms also
            slowly reduces folate to 5,6,7,8-tetrahydrofolate.
            Inhibited by trimethoprim (Proc.NAS USA 89,11322-11326(1992))
PATHWAY     PATH: MAP00670  One carbon pool by folate
            PATH: MAP00790  Folate biosynthesis
GENES       ECO: b0048(folA)
            ECE: Z0055
            ECS: ECs0051
            YPE: YPO0486(folA)
            HIN: HI0899(folA)
            PMU: PM1893(folA)
            XFA: XF2331
            VCH: VC0440
            PAE: PA0350(folA)
            BUC: BU143(folA)
            NME: NMB0308
            NMA: NMA2179(folA)
            RCO: RC0034(folA)
            MLO: mll1457
            SME: SMc01442(folA)
            CCR: CC2126
            BSU: BG10795(dfrA)
            BHA: BH3450(dfrA)
            SAU: SA1259(dfrA)
            SAV: SAV1414(dfrA)
            LLA: L162872(dfrA)
            SPY: SPy0883(dyr)
            SPN: SP1571
            SPR: spr1429(dfr)
            CAC: CAC3004(folA)
            MGE: MG228(folA)
            MPN: F10_orf160(dhfr)
            MPU: MYPU_5370(dhfr)
            UUR: UU114(folA)
            MTU: Rv2763c(dfrA)
            MTC: MT2833
            MLE: ML1518(folA)
            CTR: CT612
            CMU: TC0902
            CPN: CPn0759
            CPA: CP1113
            CPJ: folA
            DRA: DR2632
            TMA: TM1641
            SCE: YOR236W(DFR1)
            SPO: DFR1(dfr1)
            ATH: At2g16370(F16F14.13) At4g34570(T4L20.150)
            CEL: C36B1.7
            DME: CG14887(Dhfr)
            MMU: 94890(Dhfr)
            HSA: 1719(DHFR)
DISEASE     MIM: 126060  Dihydrofolate reductase
MOTIF       PS: PS00075  [LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-
                         [FYIV]-x(3)-[STIQ]
            PS: PS00091  R-x(2)-[LIVM]-x(3)-[FW]-[QN]-x(8,9)-[LV]-x-P-C-[HAVM]-
                         x(3)-[QMT]-[FYW]-x-[LV]
STRUCTURES  PDB: 2CD2  1IA2  1HFR  1IA1  8DFR  1AI9  1AO8  1AOE  1BOZ  1BZF  
                 1CD2  1CZ3  1D1G  1D8R  1DAJ  1DDR  1DDS  1DF7  1DG5  1DG7  
                 1DG8  1DHF  1DHI  1DHJ  1DIS  1DIU  1DLR  1DLS  1DR1  1DR2  
                 1DR3  1DR4  1DR5  1DR6  1DR7  1DRA  1DRB  1DRE  1DRF  1DRH  
                 1DYH  1DYI  1DYJ  1DYR  1E26  1HFP  1HFQ  1IA3  1RX2  7DFR  
                 6DFR  1IA4  1JOL  1JOM  1OHJ  1OHK  1RA1  1RA2  1RA3  1RA8  
                 1RA9  1RB2  1RB3  1RC4  1RD7  1RE7  1RF7  1RG7  1RH3  1RX1  
                 1RX3  1VIE  1RX4  1RX5  1RX6  1RX7  1RX8  1RX9  1TDR  1VDR  
                 1VIF  2DHF  2DRC  3CD2  3DFR  3DRC  4CD2  4DFR  5DFR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.3
            ExPASy - ENZYME nomenclature database: 1.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.3
            BRENDA, the Enzyme Database: 1.5.1.3
            SCOP (Structural Classification of Proteins): 1.5.1.3
///
ENTRY       EC 1.5.1.4
NAME        Deleted entry
            Dihydrofolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.5.1.3.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.4
            ExPASy - ENZYME nomenclature database: 1.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.4
///
ENTRY       EC 1.5.1.5
NAME        Methylenetetrahydrofolate dehydrogenase (NADP+)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
REACTION    5,10-Methylenetetrahydrofolate + NADP+ =
            5,10-Methenyltetrahydrofolate + NADPH
SUBSTRATE   5,10-Methylenetetrahydrofolate
            NADP+
PRODUCT     5,10-Methenyltetrahydrofolate
            NADPH
COMMENT     In eucaryotes occurs as a trifunctional enzyme also having
            methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and
            formyltetrahydrofolate synthase (EC 6.3.4.3) activity.
            In some procaryotes occurs as a bifunctional enzyme also having
            methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9).
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b0529(folD)
            ECE: Z0684(folD)
            ECS: ECs0591
            YPE: YPO2824(folD)
            HIN: HI0609(folD)
            PMU: PM1933(folD)
            XFA: XF2431
            VCH: VC1942
            PAE: PA1796(folD)
            BUC: BU486(folD)
            NMA: NMA0354(folD)
            HPY: HP0577(folD)
            HPJ: jhp0524
            CJE: Cj0855(folD)
            RPR: RP515(folD)
            RCO: RC0636(folD)
            MLO: mlr6508
            SME: SMc02604(folD1) SMc03059(folD2)
            CCR: CC1217
            BSU: BG11711(folD)
            BHA: BH2784(folD)
            SAU: SA0915(folD)
            SAV: SAV1049(folD)
            LLA: L76582(folD)
            SPY: SPy1502(folD)
            SPN: SP0825
            SPR: spr0729(folD)
            CAC: CAC2083(folD)
            MGE: MG013(folD)
            MPN: D12_orf269(mtd1)
            MPU: MYPU_2580(folD)
            UUR: UU337(folD)
            MTU: Rv3356c(folD)
            MTC: MT3464
            MLE: ML0674(folD)
            CTR: CT078
            CMU: TC0350
            CPN: CPn0335
            CPA: CP0423
            CPJ: folD
            BBU: BB0026(folD)
            TPA: TP0732
            SYN: sll0753(folD)
            DRA: DR0867
            AAE: aq_1898(folD)
            TMA: TM1767
            HAL: VNG1416G(folD)
            TAC: Ta0898
            TVO: TVG1072456
            SCE: YBR084W(MIS1) YGR204W(ADE3)
            SPO: SPBC2G2.08(spbc2g2.08) SPBC839.16(spbc839.16)
            CEL: K07E3.3
            HSA: 4522(MTHFD1)
MOTIF       PS: PS00721  G-[LIVM]-K-G-G-A-A-G-G-G-Y
            PS: PS00722  V-A-T-[IV]-R-A-L-K-x-[HN]-G-G
            PS: PS00766  [EQ]-x-[EQK]-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVMY]-N-x-
                         [DN]-x(5)-[LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-[IV]
STRUCTURES  PDB: 1DIB  1DIG  1A4I  1DIA  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.5
            ExPASy - ENZYME nomenclature database: 1.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.5
            BRENDA, the Enzyme Database: 1.5.1.5
            SCOP (Structural Classification of Proteins): 1.5.1.5
///
ENTRY       EC 1.5.1.6
NAME        Formyltetrahydrofolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     10-Formyltetrahydrofolate:NADP+ oxidoreductase
REACTION    10-Formyltetrahydrofolate + NADP+ + H2O = Tetrahydrofolate +
            CO2 + NADPH
SUBSTRATE   10-Formyltetrahydrofolate
            NADP+
            H2O
PRODUCT     Tetrahydrofolate
            CO2
            NADPH
PATHWAY     PATH: MAP00670  One carbon pool by folate
GENES       CEL: F36H1.6
            DME: CG8665
            HSA: 10840(FTHFD)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00373  G-x-[STM]-[IVT]-x-[FYWVQ]-[VMAT]-x-[DEVM]-x-[LIVMY]-D-
                         x-G-x(2)-[LIVT]-x(6)-[LIVM]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.6
            ExPASy - ENZYME nomenclature database: 1.5.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.6
            BRENDA, the Enzyme Database: 1.5.1.6
///
ENTRY       EC 1.5.1.7
NAME        Saccharopine dehydrogenase (NAD+, L-lysine forming)
            Lysine--2-oxoglutarate reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase
            $ (L-lysine-forming)
REACTION    N6-(L-1,3-Dicarboxypropyl)-L-lysine + NAD+ + H2O = L-Lysine +
            2-Oxoglutarate + NADH
SUBSTRATE   N6-(L-1,3-Dicarboxypropyl)-L-lysine
            NAD+
            H2O
PRODUCT     L-Lysine
            2-Oxoglutarate
            NADH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00310  Lysine degradation
GENES       SCE: YIR034C(LYS1)
            SPO: LYS3(lys3)
STRUCTURES  PDB: 1FF9  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.7
            ExPASy - ENZYME nomenclature database: 1.5.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.7
            BRENDA, the Enzyme Database: 1.5.1.7
            SCOP (Structural Classification of Proteins): 1.5.1.7
///
ENTRY       EC 1.5.1.8
NAME        Saccharopine dehydrogenase (NADP+, L-lysine forming)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
            $ (L-lysine-forming)
REACTION    N6-(L-1,3-Dicarboxypropyl)-L-lysine + NADP+ + H2O = L-Lysine +
            2-Oxoglutarate + NADPH
SUBSTRATE   N6-(L-1,3-Dicarboxypropyl)-L-lysine
            NADP+
            H2O
PRODUCT     L-Lysine
            2-Oxoglutarate
            NADPH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.8
            ExPASy - ENZYME nomenclature database: 1.5.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.8
            BRENDA, the Enzyme Database: 1.5.1.8
///
ENTRY       EC 1.5.1.9
NAME        Saccharopine dehydrogenase (NAD+, L-glutamate forming)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase
            $ (L-glutamate-forming)
REACTION    N6-(L-1,3-Dicarboxypropyl)-L-lysine + NAD+ + H2O = L-Glutamate +
            L-2-Aminoadipate 6-semialdehyde + NADH
SUBSTRATE   N6-(L-1,3-Dicarboxypropyl)-L-lysine
            NAD+
            H2O
PRODUCT     L-Glutamate
            L-2-Aminoadipate 6-semialdehyde
            NADH
PATHWAY     PATH: MAP00310  Lysine degradation
GENES       HSA: 10157(LKR/SDH)
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.9
            ExPASy - ENZYME nomenclature database: 1.5.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.9
            BRENDA, the Enzyme Database: 1.5.1.9
///
ENTRY       EC 1.5.1.10
NAME        Saccharopine dehydrogenase (NADP+, L-glutamate forming)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
REACTION    N6-(L-1,3-Dicarboxypropyl)-L-lysine + NADP+ + H2O = L-Glutamate +
            L-2-Aminoadipate 6-semialdehyde + NADPH
SUBSTRATE   N6-(L-1,3-Dicarboxypropyl)-L-lysine
            NADP+
            H2O
PRODUCT     L-Glutamate
            L-2-Aminoadipate 6-semialdehyde
            NADPH
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       SCE: YNR050C(LYS9)
STRUCTURES  PDB: 1E5Q  1E5L  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.10
            ExPASy - ENZYME nomenclature database: 1.5.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.10
            BRENDA, the Enzyme Database: 1.5.1.10
            SCOP (Structural Classification of Proteins): 1.5.1.10
///
ENTRY       EC 1.5.1.11
NAME        D-Octopine dehydrogenase
            D-Octopine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N2-(D-1-Carboxyethyl)-L-arginine:NAD+ oxidoreductase
REACTION    N2-(D-1-Carboxyethyl)-L-arginine + NAD+ + H2O = L-Arginine +
            Pyruvate + NADH
SUBSTRATE   N2-(D-1-Carboxyethyl)-L-arginine
            NAD+
            H2O
PRODUCT     L-Arginine
            Pyruvate
            NADH
COMMENT     In the reverse direction acts also in L-ornithine, L-lysine and
            L-histidine
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.11
            ExPASy - ENZYME nomenclature database: 1.5.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.11
            BRENDA, the Enzyme Database: 1.5.1.11
///
ENTRY       EC 1.5.1.12
NAME        1-Pyrroline-5-carboxylate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     1-Pyrroline-5-carboxylate:NAD+ oxidoreductase
REACTION    L-1-Pyrroline-5-carboxylate + NAD+ + H2O =
            L-Glutamate + NADH
SUBSTRATE   L-1-Pyrroline-5-carboxylate
            NAD+
            H2O
            L-1-Pyrroline-3-hydroxy-5-carboxylate
PRODUCT     L-Glutamate
            NADH
            4-Hydroxy-L-glutamate
COMMENT     Oxidizes other 1-pyrrolines, e.g. 3-hydroxy-1-pyrroline-5-
            -carboxylate forms 4-hydroxyglutamate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b1014(putA)
            ECE: Z1513(putA)
            ECS: ECs1260
            YPE: YPO1851(putA)
            PMU: PM0589(putA)
            PAE: PA0782(putA)
            NME: NMB0401
            NMA: NMA2084(putA)
            HPY: HP0056
            HPJ: jhp0048
            CJE: Cj1503c(putA)
            MLO: mll1160
            SME: SMc02181(putA)
            CCR: CC0804
            BSU: BG10622(rocA) BG12012(ycgN)
            BHA: BH2737 BH3940
            SAU: SA2341(rocA)
            SAV: SAV2537(rocA)
            MTU: Rv1187(rocA)
            MTC: MT1224
            SYN: sll1561(putA)
            DRA: DR0813 DRA0030
            TAC: Ta0603
            TVO: TVG0647983
            APE: APE0807
            SCE: YHR037W(PUT2)
            SPO: SPBC24C6.04(spbc24c6.04)
            DME: CG6661 CG7145
            HSA: 8659(ALDH4A1)
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.12
            ExPASy - ENZYME nomenclature database: 1.5.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.12
            BRENDA, the Enzyme Database: 1.5.1.12
///
ENTRY       EC 1.5.1.13
NAME        Nicotinate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Nicotinate:NADP+ 6-oxidoreductase (hydroxylating)
REACTION    Nicotinate + H2O + NADP+ = 6-Hydroxynicotinate + NADPH
SUBSTRATE   Nicotinate
            H2O
            NADP+
PRODUCT     6-Hydroxynicotinate
            NADPH
COFACTOR    Iron
            FAD
COMMENT     A flavoprotein containing non-heme iron.  Also oxidizes NADPH.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.13
            ExPASy - ENZYME nomenclature database: 1.5.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.13
            BRENDA, the Enzyme Database: 1.5.1.13
///
ENTRY       EC 1.5.1.14
NAME        Deleted entry
            1,2-Didehydropipecolate reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry. Now included with EC 1.5.1.21.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.14
            ExPASy - ENZYME nomenclature database: 1.5.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.14
///
ENTRY       EC 1.5.1.15
NAME        Methylenetetrahydrofolate dehydrogenase (NAD+)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5,10-Methylenetetrahydrofolate:NAD+ oxidoreductase
REACTION    5,10-Methylenetetrahydrofolate + NAD+ =
            5,10-Methenyltetrahydrofolate + NADH
SUBSTRATE   5,10-Methylenetetrahydrofolate
            NAD+
PRODUCT     5,10-Methenyltetrahydrofolate
            NADH
PATHWAY     PATH: MAP00670  One carbon pool by folate
GENES       SCE: YKR080W(MTD1)
            DME: CG18466(Nmdmc)
            HSA: 10797(MTHFD2)
MOTIF       PS: PS00766  [EQ]-x-[EQK]-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVMY]-N-x-
                         [DN]-x(5)-[LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-[IV]
STRUCTURES  PDB: 1EE9  1EDZ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.15
            ExPASy - ENZYME nomenclature database: 1.5.1.15
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.15
            BRENDA, the Enzyme Database: 1.5.1.15
            SCOP (Structural Classification of Proteins): 1.5.1.15
///
ENTRY       EC 1.5.1.16
NAME        D-Lysopine dehydrogenase
            D-Lysopine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N2-(D-1-Carboxylethyl)-L-lysine:NADP+ oxidoreductase
            (L-lysine-forming)
REACTION    N2-(D-1-Carboxyethyl)-L-lysine + NADP+ + H2O = L-Lysine + Pyruvate
            + NADPH
SUBSTRATE   N2-(D-1-Carboxyethyl)-L-lysine
            NADP+
            H2O
PRODUCT     L-Lysine
            Pyruvate
            2-Oxobutanoate
            Glyoxylate
            NADPH
            L-Amino acid
COMMENT     In the reverse reaction, a number of L-amino acids can act
            instead of L-lysine, and 2-oxobutanoate and, to a lesser extent,
            glyoxylate, can act instead of pyruvate.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.16
            ExPASy - ENZYME nomenclature database: 1.5.1.16
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.16
            BRENDA, the Enzyme Database: 1.5.1.16
///
ENTRY       EC 1.5.1.17
NAME        Alanopine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     2,2'-Iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)
REACTION    2,2'-Iminodipropanoate + NAD+ + H2O = L-Alanine + Pyruvate + NADH
SUBSTRATE   2,2'-Iminodipropanoate
            NAD+
            H2O
PRODUCT     L-Alanine
            Pyruvate
            NADH
            L-Cysteine
            L-Serine
            L-Threonine
COMMENT     In the reverse reaction, L-alanine can be respeced by L-cysteine,
            L-serine or L-threonine; glycine acts very slowly
            (cf. EC 1.5.1.22).
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.17
            ExPASy - ENZYME nomenclature database: 1.5.1.17
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.17
            BRENDA, the Enzyme Database: 1.5.1.17
///
ENTRY       EC 1.5.1.18
NAME        Ephedrine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (-)-Ephedrine:NAD+ 2-oxidoreductase
REACTION    (-)-Ephedrine + NAD+ = (R)-2-Methylimino-1-phenylpropan-1-ol +
            NADH
SUBSTRATE   (-)-Ephedrine
            NAD+
            (-)-Sympatol
            (+)-Pseudoephedrine
            (+)-Norephedrine
PRODUCT     (R)-2-Methylimino-1-phenylpropan-1-ol
            NADH
COMMENT     The product immediately hydroxyses to methylamine and 1-hydroxy
            -1-phenylpropan-2-one.  Acts on a number of related compound
            including (-)-sympatol, (+)-pseudophedrine and (+)-norephedrine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.18
            ExPASy - ENZYME nomenclature database: 1.5.1.18
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.18
            BRENDA, the Enzyme Database: 1.5.1.18
///
ENTRY       EC 1.5.1.19
NAME        D-Nopaline dehydrogenase
            D-Nopaline synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N2-(D-1,3-Dicarboxypropyl)-L-arginine:NADP+ oxidoreductase
            (L-arginine-forming)
REACTION    N2-(D-1,3-Dicarboxypropyl)-L-arginine + NADP+ + H2O = L-Arginine
            + 2-Oxoglutarate + NADPH
SUBSTRATE   N2-(D-1,3-Dicarboxypropyl)-L-arginine
            D-Ornaline
            D-Nopaline
            NADP+
            H2O
PRODUCT     L-Arginine
            2-Oxoglutarate
            L-Ornithine
            NADPH
COMMENT     In the reverse direction, forms D-nopaline from L-arginine and
            D-ornaline from L-ornithine.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ATU: AGR_pTi_53
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.19
            ExPASy - ENZYME nomenclature database: 1.5.1.19
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.19
            BRENDA, the Enzyme Database: 1.5.1.19
///
ENTRY       EC 1.5.1.20
NAME        Methylenetetrahydrofolate reductase (NADPH)
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     5-Methyltetrahydrofolate:NADP+ oxidoreductase
REACTION    5-Methyltetrahydrofolate + NADP+ = 5,10-Methylenetetrahydrofolate
            + NADPH
SUBSTRATE   5-Methyltetrahydrofolate
            NADP+
PRODUCT     5,10-Methylenetetrahydrofolate
            NADPH
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Formerly EC 1.1.1.171.
GENES       SME: SMa2143
            SCE: YGL125W(MET13) YPL023C(MET12)
            SPO: MTHFR2(mthfr2) SPAC56F8.10(spac56f8.10)
            ATH: At2g44160(F6E13.32)
            CEL: C06A8.1
            HSA: 4524(MTHFR)
DISEASE     MIM: 236250  Methylenetetrahydrofolate reductase
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.20
            ExPASy - ENZYME nomenclature database: 1.5.1.20
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.20
            BRENDA, the Enzyme Database: 1.5.1.20
///
ENTRY       EC 1.5.1.21
NAME        delta1-Piperideine-2-carboxylate reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     L-Pipecolate:NADP+ 2-oxidoreductase
REACTION    L-Pipecolate + NADP+ = delta1-Piperideine-2-carboxylate + NADPH
SUBSTRATE   L-Pipecolate
            NADP+
PRODUCT     delta1-Piperideine-2-carboxylate
            NADPH
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.21
            ExPASy - ENZYME nomenclature database: 1.5.1.21
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.21
            BRENDA, the Enzyme Database: 1.5.1.21
///
ENTRY       EC 1.5.1.22
NAME        Strombine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-(Carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming)
REACTION    N-(Carboxymethyl)-D-alanine + NAD+ + H2O = Glycine + Pyruvate +
            NADH
SUBSTRATE   N-(Carboxymethyl)-D-alanine
            NAD+
            H2O
            2,2'-Iminodipropanoate
PRODUCT     Glycine
            Pyruvate
            NADH
            L-Alanine
COMMENT     Also catalyses the reaction of EC 1.5.1.17, more slowly.  Does
            not act on L-strombine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.22
            ExPASy - ENZYME nomenclature database: 1.5.1.22
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.22
            BRENDA, the Enzyme Database: 1.5.1.22
///
ENTRY       EC 1.5.1.23
NAME        Tauropine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N2-(D-1-Carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)
REACTION    Tauropine + NAD+ + H2O = Taurine + Pyruvate + NADH
SUBSTRATE   Tauropine
            NAD+
            H2O
PRODUCT     Taurine
            Pyruvate
            NADH
            2-Oxobutanoate
            2-Oxopentanoate
COMMENT     In the reverse reaction, alanine can act instead of taurine, more
            slowly, and 2-oxobutanoate and 2-oxopentanoate can act instead of
            pyruvate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.23
            ExPASy - ENZYME nomenclature database: 1.5.1.23
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.23
            BRENDA, the Enzyme Database: 1.5.1.23
///
ENTRY       EC 1.5.1.24
NAME        N5-(Carboxyethyl)ornithine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N5-(L-1-Carboxyethyl)-L-ornithine:NADP+ oxidoreductase
            (L-ornithine-dorming)
REACTION    N5-(L-1-Carboxyethyl)-L-ornithine + NADP+ + H2O = L-Ornithine +
            Pyruvate + NADPH
SUBSTRATE   N5-(L-1-Carboxyethyl)-L-ornithine
            NADP+
            H2O
PRODUCT     L-Ornithine
            L-Lysine
            Pyruvate
            NADPH
COMMENT     In the reverse direction, L-lysine cat act instead of L-ornithine,
            more slowly. Acts as the amino group. cf. EC 1.5.1.16.
GENES       LLA: L64332(ceo)
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.24
            ExPASy - ENZYME nomenclature database: 1.5.1.24
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.24
            BRENDA, the Enzyme Database: 1.5.1.24
///
ENTRY       EC 1.5.1.25
NAME        Thiomorpholine-carboxylate dehydrogenase
            Ketimine reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase
REACTION    Thiomorpholine 3-carboxylate + NAD+ or NADP+ =
            3,4-Dehydrothiomorpholine-3-carboxylate + NADH or NADPH
SUBSTRATE   Thiomorpholine 3-carboxylate
            NAD+
            NADP+
PRODUCT     3,4-Dehydrothiomorpholine-3-carboxylate
            NADH
            NADPH
COMMENT     The product is the cyclic imine of the 2-oxoacid corresponding to
            S-(2-aminoethyl)-cysteine.  In the reverse direction, a number of
            other cyclic unsaturated compounds can act as substrates, more
            slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.25
            ExPASy - ENZYME nomenclature database: 1.5.1.25
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.25
            BRENDA, the Enzyme Database: 1.5.1.25
///
ENTRY       EC 1.5.1.26
NAME        beta-Alanopine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     N-(D-1-Carboxyethyl)-beta-alanine:NAD+ oxidoreductase
            $ (beta-alanine-forming)
REACTION    beta-Alanopine + NAD+ + H2O = beta-Alanine + Pyruvate + NADH
SUBSTRATE   beta-Alanopine
            NAD+
            H2O
PRODUCT     beta-Alanine
            Pyruvate
            NADH
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.26
            ExPASy - ENZYME nomenclature database: 1.5.1.26
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.26
            BRENDA, the Enzyme Database: 1.5.1.26
///
ENTRY       EC 1.5.1.27
NAME        1,2-Dehydroreticulinium reductase (NADPH)
            1,2-Dehydroreticulinium ion reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    1,2-Dehydroreticulinium + NADPH = (R)-Reticuline + NADP+
SUBSTRATE   1,2-Dehydroreticulinium
            NADPH
PRODUCT     (R)-Reticuline
            NADP+
COMMENT     Stereospecifically reduces the 1,2-dehydroreticulinium ion to
            (R)-reticuline, which is a direct precursor of morphinan alkaloids
            in the poppy plant, papaver somniferum.
            The enzyme does not catalyse the reverse reaction to any
            significant extent under physiological conditions.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.27
            ExPASy - ENZYME nomenclature database: 1.5.1.27
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.27
///
ENTRY       EC 1.5.1.28
NAME        Opine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With NAD+ or NADP+ as acceptor
REACTION    (2S)-2-{[1-(R)-Carboxyethyl]amino}pentanoate + NAD+ + H2O =
            L-2-Aminopentanoic acid + Pyruvate + NADH
SUBSTRATE   (2S)-2-{[1-(R)-Carboxyethyl]amino}pentanoate
            NAD+
            H2O
PRODUCT     L-2-Aminopentanoic acid
            Pyruvate
            NADH
COMMENT     In the forward direction, the enzyme from Arthrobacter sp. acts
            also on secondary amine dicarboxylates such as N-(1-
            carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine.
            Dehydrogenation forms an imine, which dissociates to the amino acid
            and pyruvate.
            In the reverse direction, the enzyme acts also on neutral amino
            acids as an amino donor. They include L-amino acids such as
            2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid,
            3-chloroalanine, O-acetylserine, methionine, isoleucine, valine,
            phenylalanine, leucine and alanine.
            The amino acceptors include 2-oxoacids such as pyruvate,
            oxaloacetate, glyoxylate and 2-oxobutyrate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.1.28
            ExPASy - ENZYME nomenclature database: 1.5.1.28
            WIT (What Is There) Metabolic Reconstruction: 1.5.1.28
///
ENTRY       EC 1.5.3.1
NAME        Sarcosine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     Sarcosine:oxygen oxidoreductase (demethylating)
REACTION    Sarcosine + H2O + O2 = Glycine + Formaldehyde + H2O2
SUBSTRATE   Sarcosine
            H2O
            O2
PRODUCT     Glycine
            Formaldehyde
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). The flavin is both covalently and
            non-covalently bound in a molar ratio of 1:1.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b1059(solA)
            ECE: Z1696(solA)
            ECS: ECs1437
            YPE: YPO2448(solA)
            PAE: PA5416(soxB) PA5417(soxD) PA5418(soxA) PA5419(soxG)
            MLO: mll3107 mll3108 mll3111 mll5230 mll5232 mll6237 mll6238
                 mll6240 mll7022 mll7303 mll7304 mll7306 mlr1273 mlr1275
                 mlr1276 mlr8469 msl3109 msl5231 msl6239 msl7305 msr1274
            SME: SMc01856 SMc02605(soxG) SMc02606(soxA1) SMc02607(soxD)
                 SMc02608(soxB) SMc03930(soxG2) SMc03931(soxA2) SMc03932(soxD2)
                 SMc03933(soxB2)
            AFU: AF0273(soxA) AF0274(soxB)
            HAL: VNG0281G(soxB)
            PHO: PH1364 PH1749 PH1751
            PAB: PAB0212(soxA) PAB0214(soxB) PAB1842 PAB1843(soxB)
            SSO: SSO0186(soxA-like) SSO0187(soxB-like)
            STO: ST0220 ST0221
STRUCTURES  PDB: 1EL7  1EL5  1EL8  1EL9  1ELI  1B3M  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.1
            ExPASy - ENZYME nomenclature database: 1.5.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.1
            BRENDA, the Enzyme Database: 1.5.3.1
            SCOP (Structural Classification of Proteins): 1.5.3.1
///
ENTRY       EC 1.5.3.2
NAME        N-Methyl-L-amino-acid oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     N-Methyl-L-amino-acid:oxygen oxidoreductase (demethylating)
REACTION    an N-Methyl-L-amino acid + H2O + O2 = an L-Amino acid +
            Formaldehyde + H2O2
SUBSTRATE   N-Methyl-L-amino acid
            H2O
            O2
PRODUCT     L-Amino acid
            Formaldehyde
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.2
            ExPASy - ENZYME nomenclature database: 1.5.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.2
            BRENDA, the Enzyme Database: 1.5.3.2
///
ENTRY       EC 1.5.3.3
NAME        Deleted entry
            Spermine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.3
            ExPASy - ENZYME nomenclature database: 1.5.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.3
///
ENTRY       EC 1.5.3.4
NAME        N6-Methyl-lysine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     N6-Methyl-L-lysine:oxygen oxidoreductase (demethylating)
REACTION    N6-Methyl-L-lysine + H2O + O2 = L-Lysine + Formaldehyde + H2O2
SUBSTRATE   N6-Methyl-L-lysine
            H2O
            O2
PRODUCT     L-Lysine
            Formaldehyde
            H2O2
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.4
            ExPASy - ENZYME nomenclature database: 1.5.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.4
            BRENDA, the Enzyme Database: 1.5.3.4
///
ENTRY       EC 1.5.3.5
NAME        (S)-6-Hydroxynicotine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     (S)-6-Hydroxynicotine:oxygen oxidoreductase
REACTION    (S)-6-Hydroxynicotine + H2O + O2 =
            1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2
SUBSTRATE   (S)-6-Hydroxynicotine
            H2O
            O2
PRODUCT     1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.5
            ExPASy - ENZYME nomenclature database: 1.5.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.5
            UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.5
            BRENDA, the Enzyme Database: 1.5.3.5
///
ENTRY       EC 1.5.3.6
NAME        (R)-6-Hydroxynicotine oxydase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     (R)-6-Hydroxynicotine:oxygen oxidoreductase
REACTION    (R)-6-Hydroxynicotine + H2O + O2 =
            1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + H2O2
SUBSTRATE   (R)-6-Hydroxynicotine
            H2O
            O2
PRODUCT     1-(6-Hydroxypyrid-3-yl)-4-(methylamino)butan-1-one
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
MOTIF       PS: PS00862  P-x(10)-[DE]-[LIVM]-x(3)-[LIVM]-x(9)-[LIVM]-x(3)-[GSA]-
                         [GST]-G-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.6
            ExPASy - ENZYME nomenclature database: 1.5.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.6
            UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.6
            BRENDA, the Enzyme Database: 1.5.3.6
///
ENTRY       EC 1.5.3.7
NAME        L-Pipecolate oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     L-Pipecolate:oxygen 1,6-oxidoreductase
REACTION    L-Pipecolate + O2 = 2,3,4,5-Tetrahydropyridine-2-carboxylate +
            H2O2
SUBSTRATE   L-Pipecolate
            O2
PRODUCT     2,3,4,5-Tetrahydropyridine-2-carboxylate
            H2O2
COMMENT     The product reacts with water to form 2-aminoadipate
            6-semialdehyde, i.e. 2-amino-6-oxohexanoate.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.7
            ExPASy - ENZYME nomenclature database: 1.5.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.7
            BRENDA, the Enzyme Database: 1.5.3.7
///
ENTRY       EC 1.5.3.8
NAME        Deleted entry
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
COMMENT     Deleted entry. Now included with EC 1.3.3.8 -
            Tetrahydroberberine oxidase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.8
            ExPASy - ENZYME nomenclature database: 1.5.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.8
            BRENDA, the Enzyme Database: 1.5.3.8
///
ENTRY       EC 1.5.3.9
NAME        Reticuline oxidase
            Berberine-bridge-forming enzyme
            Tetrahydroprotoberberine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     (S)-Reticuline:oxygen oxidoreductase (methylene-bridge-forming)
REACTION    (S)-Reticuline + O2 = (S)-Scoulerine + H2O2
SUBSTRATE   (S)-Reticuline
            O2
PRODUCT     (S)-Scoulerine
            H2O2
COMMENT     Acts on (S)-reticuline and related compounds, converting the
            N-methyl group into the methylene bridge ('berberine bridge') of
            (S)-tetrahydroprotoberberines.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
MOTIF       PS: PS00862  P-x(10)-[DE]-[LIVM]-x(3)-[LIVM]-x(9)-[LIVM]-x(3)-[GSA]-
                         [GST]-G-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.9
            ExPASy - ENZYME nomenclature database: 1.5.3.9
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.9
            BRENDA, the Enzyme Database: 1.5.3.9
///
ENTRY       EC 1.5.3.10
NAME        Dimethylglycine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     N,N-Dimethylglycine:oxygen oxidoreductase (demethylating)
REACTION    N,N-Dimethylglycine + H2O + O2 = Sarcosine + Formaldehyde + H2O2
SUBSTRATE   N,N-Dimethylglycine
            H2O
            O2
PRODUCT     Sarcosine
            Formaldehyde
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Does not oxidize sarcosine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.10
            ExPASy - ENZYME nomenclature database: 1.5.3.10
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.10
            BRENDA, the Enzyme Database: 1.5.3.10
///
ENTRY       EC 1.5.3.11
NAME        Polyamine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
SYSNAME     N1-Acetylspermidine:oxygen oxidoreductase (deaminating)
REACTION    N1-Acetylspermine + O2 + H2O = N1-Acetylspermidine +
            3-Aminopropanal + H2O2
SUBSTRATE   N1-Acetylspermine
            O2
            H2O
            N1-Acetylspermidine
            N1,N12-Diacetylspermine
PRODUCT     N1-Acetylspermidine
            3-Aminopropanal
            H2O2
COFACTOR    FAD
            Iron
COMMENT     A flavoprotein requiring Fe2+.  Also acts on N1-acetylspermidine
            and N1,N12-diacetylspermine.
STRUCTURES  PDB: 1B37  1H81  1H82  1H83  1H84  1H86  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.11
            ExPASy - ENZYME nomenclature database: 1.5.3.11
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.11
            BRENDA, the Enzyme Database: 1.5.3.11
            SCOP (Structural Classification of Proteins): 1.5.3.11
///
ENTRY       EC 1.5.3.12
NAME        Dihydrobenzophenanthridine oxidase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With oxygen as acceptor
REACTION    Dihydrosanguinarine + O2 = Sanguinarine + H2O2;
            Dihydrochelirubine + O2 = Chelirubine + H2O2;
            Dihydromacarpine + O2 = Macarpine + H2O2
SUBSTRATE   Dihydrosanguinarine
            O2
            Dihydrochelirubine
            Dihydromacarpine
PRODUCT     Sanguinarine
            H2O2
            Chelirubine
            Macarpine
COFACTOR    Copper
COMMENT     Also catalyzes: dihydrochelirubine + O2 = chelirubine + H2O2.
            Also catalyzes: dihydromacarpine + O2 = macarpine + H2O2.
            Found in higher plants.
            Produces oxidized forms of the benzophenanthridine alkaloids.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.3.12
            ExPASy - ENZYME nomenclature database: 1.5.3.12
            WIT (What Is There) Metabolic Reconstruction: 1.5.3.12
///
ENTRY       EC 1.5.4.1
NAME        Pyrimidodiazepine synthase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With a disulfide as acceptor
SYSNAME     Pyrimidodiazepine:oxidized-glutathione oxidoreductase
            $ (ring-opening, cyclizing)
REACTION    a Pyrimidodiazepine + Oxidized glutathione =
            6-Pyruvoyltetrahydropterin + 2 Glutathione
SUBSTRATE   Pyrimidodiazepine
            Oxidized glutathione
PRODUCT     6-Pyruvoyltetrahydropterin
            Glutathione
COMMENT     In the reverse direction of reaction, the reduction of 6-pyruvoyl-
            tetrahydropterin is accompanied by the opening of the 6-membered
            pyrazine ring and the formation of the 7-membered diazepine ring.
            The pyrimidodiazepine involved is an acetyldihydro derivative.
            Involved in the formation of the eye pigment drosopterin in
            Drosophila melanogaster.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.4.1
            ExPASy - ENZYME nomenclature database: 1.5.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.5.4.1
            BRENDA, the Enzyme Database: 1.5.4.1
///
ENTRY       EC 1.5.5.1
NAME        Electron-transferring-flavoprotein dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With a quinone or similar compound as acceptor
SYSNAME     Electron-transferring-flavoprotein:ubiquinone oxidoreductase
REACTION    Reduced electron-transferring flavoprotein + Ubiquinone =
            Electron-transferring flavoprotein + Ubiquinol
SUBSTRATE   Reduced electron-transferring flavoprotein
            Ubiquinone
PRODUCT     Electron-transferring flavoprotein
            Ubiquinol
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     An iron-sulfur flavoprotein, forming part of the mitochondrial
            electron-transfer system.
GENES       XFA: XF1298
            PAE: PA2953
            NME: NMB0581
            NMA: NMA0766
            MLO: mlr7709
            SME: SMc02377(etf)
            CCR: CC1334
            SCE: YOR356W
            SPO: SPAC20G8.04C(spac20g8.04c)
            CEL: let-721
            DME: CG12140
            HSA: 2110(ETFDH)
DISEASE     MIM: 231675  Electron transfer flavoprotein:ubiquinone
                         oxidoreductase
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.5.1
            ExPASy - ENZYME nomenclature database: 1.5.5.1
            WIT (What Is There) Metabolic Reconstruction: 1.5.5.1
            BRENDA, the Enzyme Database: 1.5.5.1
///
ENTRY       EC 1.5.99.1
NAME        Sarcosine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     Sarcosine:(acceptor) oxidoreductase (demethylating)
REACTION    Sarcosine + Acceptor + H2O = Glycine + Formaldehyde +
            Reduced acceptor
SUBSTRATE   Sarcosine
            Acceptor
            H2O
PRODUCT     Glycine
            Formaldehyde
            Reduced acceptor
COFACTOR    FMN
COMMENT     A flavoprotein (FMN).
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       MLO: mll5369 mlr1213 mlr1283
            DME: CG6385
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.1
            ExPASy - ENZYME nomenclature database: 1.5.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.1
            BRENDA, the Enzyme Database: 1.5.99.1
///
ENTRY       EC 1.5.99.2
NAME        Dimethylglycine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     N,N-Dimethylglycine:(acceptor) oxidoreductase (demethylating)
REACTION    N,N-Dimethylglycine + Acceptor + H2O = Sarcosine + Formaldehyde +
            Reduced acceptor
SUBSTRATE   N,N-Dimethylglycine
            Acceptor
            H2O
PRODUCT     Sarcosine
            Formaldehyde
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       MLO: mll1517 mll1653 mll2449 mlr1280
            HSA: 29958(DMGDH)
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.2
            ExPASy - ENZYME nomenclature database: 1.5.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.2
            BRENDA, the Enzyme Database: 1.5.99.2
///
ENTRY       EC 1.5.99.3
NAME        L-Pipecolate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     L-Pipecolate:(acceptor) 1,6-oxidoreductase
REACTION    L-Pipecolate + Acceptor =
            2,3,4,5-Tetrahydropyridine-2-carboxylate + Reduced acceptor
SUBSTRATE   L-Pipecolate
            Acceptor
PRODUCT     2,3,4,5-Tetrahydropyridine-2-carboxylate
            Reduced acceptor
COMMENT     The product reacts with water to form 2-aminoadipate
            6-semialdehyde, i.e. 2-amino-6-oxohexanoate.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.3
            ExPASy - ENZYME nomenclature database: 1.5.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.3
            BRENDA, the Enzyme Database: 1.5.99.3
///
ENTRY       EC 1.5.99.4
NAME        Nicotine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     Nicotine:(acceptor) 6-oxidoreductase (hydroxylating)
REACTION    Nicotine + Acceptor + H2O = (S)-6-Hydroxynicotine +
            Reduced acceptor
SUBSTRATE   Nicotine
            Acceptor
            H2O
PRODUCT     (S)-6-Hydroxynicotine
            Reduced acceptor
COFACTOR    FMN
            Metal
COMMENT     A metalloprotein (FMN).  Acts on both (R)- and (S)-isomers.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.4
            ExPASy - ENZYME nomenclature database: 1.5.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.4
            UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.4
            BRENDA, the Enzyme Database: 1.5.99.4
///
ENTRY       EC 1.5.99.5
NAME        Methylglutamate dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     N-Methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)
REACTION    N-Methyl-L-glutamate + Acceptor + H2O = L-Glutamate +
            Formaldehyde + Reduced acceptor
SUBSTRATE   N-Methyl-L-glutamate
            Acceptor
            H2O
            2,6-Dichloroindophenol
PRODUCT     L-Glutamate
            Formaldehyde
            Reduced acceptor
COMMENT     A number of N-methyl-substituted amino acids can act as donor;
            2,6-dichloroindophenol is the best acceptor.
PATHWAY     PATH: MAP00680  Methane metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.5
            ExPASy - ENZYME nomenclature database: 1.5.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.5
            BRENDA, the Enzyme Database: 1.5.99.5
///
ENTRY       EC 1.5.99.6
NAME        Spermidine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     Spermidine:(acceptor) oxidoreductase
REACTION    Spermidine + Acceptor + H2O = 1,3-Diaminopropane +
            4-Aminobutanal + Reduced acceptor
SUBSTRATE   Spermidine
            Acceptor
            H2O
            Ferricyanide
            2,6-Dichloroindophenol
            Cytochrome c
PRODUCT     1,3-Diaminopropane
            4-Aminobutanal
            Reduced acceptor
COFACTOR    FAD
            Heme
COMMENT     A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol
            and cytochrome c can act as acceptor. 4-Aminobutanal condenses
            non-enzymically to 1-pyrroline.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       CCR: CC0359
            MJA: MJ0814
            MTH: MTH127
            AFU: AF2195(dys1-1) AF2300(dys1-2)
            HAL: VNG1432G(dhs)
            TAC: Ta0356
            TVO: TVG0406345
            PHO: PH1397
            PAB: PAB0511(dys1)
            APE: APE0698
            SSO: SSO0967
            STO: ST1293
            SCE: YHR068W(DYS1)
            SPO: SPBC1271.04C(spbc1271.04c)
            CEL: Y17G7B.4
            DME: CG8005
            HSA: 1725(DHPS)
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.6
            ExPASy - ENZYME nomenclature database: 1.5.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.6
            BRENDA, the Enzyme Database: 1.5.99.6
///
ENTRY       EC 1.5.99.7
NAME        Trimethylamine dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     Trimethylamine:(acceptor) oxidoreductase (demethylating)
REACTION    Trimethylamine + H2O + Acceptor = Dimethylamine + Formaldehyde
            + Reduced acceptor
SUBSTRATE   Trimethylamine
            Trimethylamine(alkyl-substituted derivatives)
            H2O
            Acceptor
            Phenazine methosulfate
            2,6-Dichloroindophenol
PRODUCT     Dimethylamine
            Formaldehyde
            Reduced acceptor
COMMENT     A number of alkyl-substituted derivatives of trimethylamine can
            also act as electron donor, phenazine methosulfate and
            2,6-dichloroindophenol can act as electron acceptors.
PATHWAY     PATH: MAP00680  Methane metabolism
GENES       SAU: SA0311
            SAV: SAV0312
            SPY: SPy1219
STRUCTURES  PDB: 2TMD  1DJQ  1DJN  
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.7
            ExPASy - ENZYME nomenclature database: 1.5.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.7
            BRENDA, the Enzyme Database: 1.5.99.7
            SCOP (Structural Classification of Proteins): 1.5.99.7
///
ENTRY       EC 1.5.99.8
NAME        Proline dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     L-Proline:(acceptor) oxidoreductase
REACTION    L-Proline + Acceptor + H2O = (S)-1-Pyrroline-5-carboxylate +
            Reduced acceptor
SUBSTRATE   L-Proline
            Acceptor
            H2O
PRODUCT     (S)-1-Pyrroline-5-carboxylate
            Reduced acceptor
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b1014(putA)
            ECE: Z1513(putA)
            ECS: ECs1260
            YPE: YPO1851(putA)
            PMU: PM0589(putA)
            PAE: PA0782(putA)
            NME: NMB0401
            NMA: NMA2084(putA)
            CJE: Cj1503c(putA)
            MLO: mll1160
            SME: SMc02181(putA)
            CCR: CC0804
MOTIF       PS: PS00070  [FYLVA]-x(3)-G-[QE]-x-C-[LIVMGSTANC]-[AGCN]-x-
                         [GSTADNEKR]
            PS: PS00687  [LIVMFGA]-E-[LIMSTAC]-[GS]-G-[KNLM]-[SADN]-[TAPFV]
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.8
            ExPASy - ENZYME nomenclature database: 1.5.99.8
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.8
            BRENDA, the Enzyme Database: 1.5.99.8
///
ENTRY       EC 1.5.99.9
NAME        Methylenetetrahydromethanopterin dehydrogenase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     5,10-Methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase
REACTION    5,10-Methylenetetrahydromethanopterin + Coenzyme F420 =
            5,10-Methenyltetrahydromethanopterin + Reduced coenzyme F420
SUBSTRATE   5,10-Methylenetetrahydromethanopterin
            Coenzyme F420
PRODUCT     5,10-Methenyltetrahydromethanopterin
            Reduced coenzyme F420
COMMENT     Coenzyme F420 is a 7,8-didemethyl-8-hydroxy-5-deazariboflavin
            derivative; methanopterin is a pterin analogue. The enzyme is
            involved in the formation of methane from CO2 in
            Methanobacterium thermoautotrophicum.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       MJA: MJ0715 MJ1035(mtd) MJ1338 MJ1534(mer)
            MTH: MTH1464(mtd) MTH1512 MTH1752 MTH504
            AFU: AF0714(mtd) AF1066(mer-1) AF1196(mer-2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.9
            ExPASy - ENZYME nomenclature database: 1.5.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.9
            UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.9
            BRENDA, the Enzyme Database: 1.5.99.9
///
ENTRY       EC 1.5.99.10
NAME        Dimethylamine dehydrogenase
            DMADh
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
REACTION    Dimethylamine + H2O + Acceptor = Methylamine + Formaldehyde +
            Reduced acceptor
SUBSTRATE   Dimethylamine
            H2O
            Acceptor
PRODUCT     Methylamine
            Formaldehyde
            Reduced acceptor
COFACTOR    FMN
PATHWAY     PATH: MAP00680  Methane metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.10
            ExPASy - ENZYME nomenclature database: 1.5.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.10
///
ENTRY       EC 1.5.99.11
NAME        Coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin
            $reductase
            Methylene-H4MPT reductase
CLASS       Oxidoreductases
            Acting on the CH-NH group of donors
            With other acceptors
SYSNAME     N5,N10-methylenetetrahydromethanopterin:coenzyme-F420
            oxidoreductase
REACTION    N5,N10-Methylenetetrahydromethanopterin + Reduced coenzyme F420 =
            5-Methyl-5,6,7,8-tetrahydromethanopterin + Coenzyme F420
SUBSTRATE   N5,N10-Methylenetetrahydromethanopterin
            Reduced coenzyme F420
PRODUCT     5-Methyl-5,6,7,8-tetrahydromethanopterin
            Coenzyme F420
COMMENT     Catalyses an intermediate step in methanogenesis from CO2 and H2 in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.5.99.11
            ExPASy - ENZYME nomenclature database: 1.5.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.5.99.11
            UM-BBD (Biocatalysis/Biodegradation Database): 1.5.99.11
///
ENTRY       EC 1.6.1.1
NAME        NAD(P)+ transhydrogenase (B-specific)
            Pyridine nucleotide transhydrogenase
            Transhydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With NAD+ or NADP+ as acceptor
SYSNAME     NADPH:NAD+ oxidoreductase (B-specific)
REACTION    NADPH + NAD+ = NADP+ + NADH
SUBSTRATE   NADPH
            NAD+
PRODUCT     NADP+
            NADH
COFACTOR    FAD
COMMENT     The enzyme from Azotobacter vinelandii is a flavoprotein (FAD).
            It is B-specific with respect to both NAD+ and NADP+.
            Also acts on deamino coenzymes (cf. EC 1.6.1.2).
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b3962(udhA)
            ECE: Z5521(udhA)
            ECS: ECs4891
            YPE: YPO3914(sthA)
            VCH: VC0151
            PAE: PA2991(sth)
            RCO: RC0104(pntB) RC1334(pntAA)
            SME: SMc03938(pntB) SMc03939(pntAb) SMc03950(pntAa)
            MTU: Rv2713
            MTC: MT2786
            MMU: 109279(Nnt)
MOTIF       PS: PS00836  G-[LIVM]-P-x-E-x(3)-N-E-x(1,3)-R-V-A-x-[ST]-P-x-[GST]-
                         V-x(2)-L-x-[KRH]-x-G
            PS: PS00837  [LIVM](2)-G-[GA]-G-x-A-G-x(2)-[SA]-x(3)-[GA]-x-[SG]-
                         [LIVM]-G-A-x-V-x(3)-D
STRUCTURES  PDB: 1E3T  1DJL  1F8G  1HZZ  1D4O  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.1.1
            ExPASy - ENZYME nomenclature database: 1.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.1.1
            BRENDA, the Enzyme Database: 1.6.1.1
            SCOP (Structural Classification of Proteins): 1.6.1.1
///
ENTRY       EC 1.6.1.2
NAME        NAD(P)+ transhydrogenase (AB-specific)
            Pyridine nucleotide transhydrogenase
            Transhydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With NAD+ or NADP+ as acceptor
SYSNAME     NADPH:NAD+ oxidoreductase (AB-specific)
REACTION    NADPH + NAD+ = NADP+ + NADH
SUBSTRATE   NADPH
            NAD+
PRODUCT     NADP+
            NADH
COMMENT     The enzyme from heart mitochondria is A-specific with respect to
            NAD+ and B-specific with respect to NADP+ (cf. EC 1.6.1.1).
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b1602(pntB) b1603(pntA)
            ECE: Z2597(pntB) Z2600(pntA)
            ECS: ECs2308 ECs2309
            YPE: YPO2302(pntB) YPO2303(pntA)
            HIN: HI1362(pntA) HI1363(pntB)
            PMU: PM0752(pntB) PM0753(pntA)
            VCH: VCA0563 VCA0564
            PAE: PA0196(pntB)
            NME: NMB0978 NMB0980
            NMA: NMA1175(pntB) NMA1177(pntA)
            RPR: RP074(pntB) RP862(pntAB) RP863(pntAA)
            MLO: mlr5181 mlr5183 mlr5184
            CCR: CC3303 CC3304 CC3305
            MTU: Rv0155(pntAA) Rv0156(pntAB) Rv0157(pntB)
            MTC: MT0165
            MLE: ML2634(pntB) ML2635(pntAB) ML2636(pntAA)
            SYN: slr1239(pntA) slr1434(pntB)
            CEL: C15H9.1
            HSA: 23530(NNT)
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.1.2
            ExPASy - ENZYME nomenclature database: 1.6.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.1.2
            BRENDA, the Enzyme Database: 1.6.1.2
///
ENTRY       EC 1.6.2.1
NAME        Transferred to EC 1.6.99.3
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
COMMENT     Transferred entry. Now EC 1.6.99.3 - NADH dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.1
            ExPASy - ENZYME nomenclature database: 1.6.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.1
///
ENTRY       EC 1.6.2.2
NAME        Cytochrome-b5 reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
SYSNAME     NADH:ferricytochrome-b5 oxidoreductase
REACTION    NADH + 2 Ferricytochrome b5 = NAD+ + 2 Ferrocytochrome b5
SUBSTRATE   NADH
            Ferricytochrome b5
PRODUCT     NAD+
            Ferrocytochrome b5
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       SCE: YIL043C(CBR1) YKL150W(MCR1)
            SPO: SPAC17H9.12C(spac17h9.12c)
            CEL: T05H4.4 T05H4.5
            DME: CG5946
            MMU: 94893(Dia1)
            HSA: 1727(DIA1)
DISEASE     MIM: 250800  Diaphorase (NADH); cytochrome b-5 reductase
STRUCTURES  PDB: 1NDH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.2
            ExPASy - ENZYME nomenclature database: 1.6.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.2
            BRENDA, the Enzyme Database: 1.6.2.2
            SCOP (Structural Classification of Proteins): 1.6.2.2
///
ENTRY       EC 1.6.2.3
NAME        Deleted entry
            Cytochrome reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.3
            ExPASy - ENZYME nomenclature database: 1.6.2.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.3
///
ENTRY       EC 1.6.2.4
NAME        NADPH--ferrihemoprotein reductase
            NADP--cytochrome reductase
            TPNH2 cytochrome c reductase
            Ferrihemoprotein P-450 reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
SYSNAME     NADPH:ferrihemoprotein oxidoreductase
REACTION    NADPH + 2 Ferricytochrome = NADP+ + 2 Ferrocytochrome
SUBSTRATE   NADPH
            Ferricytochrome
PRODUCT     NADP+
            Ferrocytochrome
COFACTOR    FMN
            FAD
COMMENT     A flavoprotein (FMN, FAD). The enzyme catalyses the reduction of
            the heme-thiolate-dependent monooxygenases, such as EC 1.14.14.1,
            and is part of the microsomal hydroxylating system.  Also reduces
            cytochrome b5 and cytochrome c.
GENES       BSU: BG12299(yrhJ) BG12871(yetO)
            SCE: YHR042W(NCP1)
            SPO: CCR1(ccr1) SPAC1296.06(spac1296.06)
            CEL: K10D2.6
            DME: CG11567(Cpr)
            MMU: 97744(Por)
            HSA: 5447(POR)
DISEASE     MIM: 124015  Cytochrome P-450 reductase
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
STRUCTURES  PDB: 1AMO  1J9Z  1JA0  1JA1  1B1C  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.4
            ExPASy - ENZYME nomenclature database: 1.6.2.4
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.4
            BRENDA, the Enzyme Database: 1.6.2.4
            SCOP (Structural Classification of Proteins): 1.6.2.4
///
ENTRY       EC 1.6.2.5
NAME        NADPH--cytochrome c2 reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
SYSNAME     NADPH:ferricytochrome-c2 oxidoreductase
REACTION    NADPH + 2 Ferricytochrome c2 = NADP+ + 2 Ferrocytochrome c2
SUBSTRATE   NADPH
            Ferricytochrome c2
PRODUCT     NADP+
            Ferrocytochrome c2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD)
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.5
            ExPASy - ENZYME nomenclature database: 1.6.2.5
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.5
            BRENDA, the Enzyme Database: 1.6.2.5
///
ENTRY       EC 1.6.2.6
NAME        Leghemoglobin reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a heme protein as acceptor
SYSNAME     NAD(P)H:ferrileghemoglobin oxidoreductase
REACTION    NADH or NADPH + 2 Ferrileghemoglobin = NAD+ or NADP+ +
            2 Ferroleghemoglobin
SUBSTRATE   NADH
            NADPH
            Ferrileghemoglobin
PRODUCT     NAD+
            NADP+
            Ferroleghemoglobin
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.2.6
            ExPASy - ENZYME nomenclature database: 1.6.2.6
            WIT (What Is There) Metabolic Reconstruction: 1.6.2.6
            BRENDA, the Enzyme Database: 1.6.2.6
///
ENTRY       EC 1.6.4.1
NAME        Cystine reductase (NADH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADH:L-cystine oxidoreductase
REACTION    NADH + L-Cystine = NAD+ + 2 L-Cysteine
SUBSTRATE   NADH
            L-Cystine
PRODUCT     NAD+
            L-Cysteine
PATHWAY     PATH: MAP00272  Cysteine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.1
            ExPASy - ENZYME nomenclature database: 1.6.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.1
            BRENDA, the Enzyme Database: 1.6.4.1
///
ENTRY       EC 1.6.4.2
NAME        Glutathione reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADPH:oxidized-glutathione oxidoreductase
REACTION    NADPH + Oxidized glutathione = NADP+ + 2 Glutathione
SUBSTRATE   NADPH
            Oxidized glutathione
PRODUCT     NADP+
            Glutathione
COFACTOR    FAD
COMMENT     A dimeric flavoprotein (FAD); activity is dependent on a
            redox-active disulfide in each of the active centres.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
GENES       ECO: b3500(gor)
            ECE: Z4900(gor)
            YPE: YPO3977(gor)
            HIN: HI0161(gor)
            PMU: PM1235(gor)
            VCH: VC0186
            PAE: PA2025(gor)
            MLO: mll0523
            SME: SMc00154(gor)
            CCR: CC2302
            LLA: L0197(gshR)
            SPY: SPy0813(gor)
            SPN: SP0784
            SPR: spr0692(gor)
            MTU: Rv2855(gorA)
            MTC: MT2922
            SCE: YPL091W(GLR1)
            SPO: PGR1+(pgr1+) SPBC17A3.07
            CEL: C46F11.2 unc-32
            DME: CG2151 CG2151_1
            MMU: 95804(Gr1)
            HSA: 2936(GSR)
DISEASE     MIM: 138300  Glutathione reductase
MOTIF       PS: PS00076  G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P
STRUCTURES  PDB: 1BWC  1DNC  1GES  1ALG  1GER  1GET  1GEU  1GRA  1GRB  1GRE  
                 1GRF  1GRG  1GRH  1GRT  1GSN  1XAN  2GRT  3GRS  3GRT  4GR1  
                 4GRT  5GRT  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.2
            ExPASy - ENZYME nomenclature database: 1.6.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.2
            BRENDA, the Enzyme Database: 1.6.4.2
            SCOP (Structural Classification of Proteins): 1.6.4.2
///
ENTRY       EC 1.6.4.3
NAME        Transferred to EC 1.8.1.4
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
COMMENT     Transferred entry. Now EC 1.8.1.4 - Dihydrolipoamide
            dehydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.3
            ExPASy - ENZYME nomenclature database: 1.6.4.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.3
///
ENTRY       EC 1.6.4.4
NAME        Protein-disulfide reductase (NAD(P)H)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NAD(P)H:protein-disulfide oxidoreductase
REACTION    NADH or NADPH + Protein disulfide = NAD+ or NADP+ + Protein dithiol
SUBSTRATE   NADH
            NADPH
            Protein disulfide
PRODUCT     NAD+
            NADP+
            Protein dithiol
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.4
            ExPASy - ENZYME nomenclature database: 1.6.4.4
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.4
            BRENDA, the Enzyme Database: 1.6.4.4
///
ENTRY       EC 1.6.4.5
NAME        Thioredoxin reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADPH:oxidized-thioredoxin oxidoreductase
REACTION    NADPH + Oxidized thioredoxin = NADP+ + Reduced thioredoxin
SUBSTRATE   NADPH
            Oxidized thioredoxin
PRODUCT     NADP+
            Reduced thioredoxin
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b0888(trxB)
            ECE: Z1232(trxB)
            ECS: ECs0973
            YPE: YPO1374(trxB)
            HIN: HI1158(trxB)
            PMU: PM0573(trxB)
            XFA: XF1448
            VCH: VC1182
            PAE: PA0849(trxB2) PA2616(trxB1)
            BUC: BU314(trxB)
            NME: NMB1324
            NMA: NMA1538(trxB)
            HPY: HP0825(trxB) HP1164(trxB)
            HPJ: jhp0764 jhp1091
            CJE: Cj0146c(trxB)
            RPR: RP445(trxB1) RP514(trxB2)
            RCO: RC0618(trxB1) RC0637(trxB2)
            MLO: mll0792 mll2552
            SME: SMc01224(trxB)
            CCR: CC2871
            BSU: BG12018(ycgT) BG12391(yumC) BG12398(trxB)
            BHA: BH3408 BH3571(trxB)
            SAU: SA0719(trxB) SA2162
            SAV: SAV0751(trxB) SAV2357
            LLA: L00196(trxB2) L0196(trxB1)
            SPY: SPy0850
            SPN: SP1458
            SPR: spr1312(trxB) spr1421(trxB) spr1602(trxA)
            CAC: CAC0869
            MGE: MG102(trxB)
            MPN: K04_orf315(trxB)
            MPU: MYPU_7130(trxB)
            UUR: UU074(trxB)
            MTU: Rv3913(trxB2)
            MTC: MT4032
            MLE: ML2703(trxB)
            CTR: CT099
            CMU: TC0375
            CPN: CPn0314
            CPA: CP0444
            CPJ: trxB
            BBU: BB0515(trxB)
            TPA: TP0814
            SYN: slr0600
            DRA: DR1982
            AAE: aq_500(trxB)
            TMA: TM0869
            MJA: MJ1536(trxB)
            MTH: MTH708
            AFU: AF1554(trxB)
            HAL: VNG1259G(trxB2) VNG6074G(trxB1_1) VNG6075G(trh_1)
                 VNG6451G(trh_2) VNG6452G(trxB1_2)
            TAC: Ta0984
            TVO: TVG1183005
            PHO: PH1426
            PAB: PAB0500(trxB)
            APE: APE1061
            SSO: SSO2222(trxB-1) SSO2416(trxB-3) SSO2765(trxB-2)
            STO: ST0438 ST0546
            SCE: YDR353W(TRR1) YHR106W(TRR2)
            SPO: TRR1(trr1)
            ATH: At4g35460(F15J1.30)
            CEL: C06G3.7
            DME: CG11401
            HSA: 7296(TXNRD1)
MOTIF       PS: PS00076  G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P
            PS: PS00194  [LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-
                         C-[GATPLVE]-[PHYWSTA]-C-x(6)-[LIVMFYWT]
            PS: PS00573  C-x(2)-C-D-[GA]-x(2,4)-[FY]-x(4)-[LIVM]-x-[LIVM](2)-
                         G(3)-[DN]
STRUCTURES  PDB: 1CL0  1F6M  1H6V  1TDE  1TDF  1TRB  1VDC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.5
            ExPASy - ENZYME nomenclature database: 1.6.4.5
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.5
            BRENDA, the Enzyme Database: 1.6.4.5
            SCOP (Structural Classification of Proteins): 1.6.4.5
///
ENTRY       EC 1.6.4.6
NAME        CoA-glutathione reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADPH:CoA-glutathione oxidoreductase
REACTION    NADPH + CoA-glutathione = NADP+ + CoA + Glutathione
SUBSTRATE   NADPH
            CoA-glutathione
PRODUCT     NADP+
            CoA
            Glutathione
COFACTOR    FAD
COMMENT     A flavoprotein.  The substrate is a mixed disulfide.
PATHWAY     PATH: MAP00272  Cysteine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.6
            ExPASy - ENZYME nomenclature database: 1.6.4.6
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.6
            BRENDA, the Enzyme Database: 1.6.4.6
///
ENTRY       EC 1.6.4.7
NAME        Asparagusate reductase (NADH)
            Asparagusate dehydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADH:asparagusate oxidoreductase
REACTION    NADH + Asparagusate = NAD+ + 3-Mercapto-2-mercaptomethylpropanoate
SUBSTRATE   NADH
            Asparagusate
            Lipoate
PRODUCT     NAD+
            3-Mercapto-2-mercaptomethylpropanoate
COMMENT     Also acts on lipoate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.7
            ExPASy - ENZYME nomenclature database: 1.6.4.7
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.7
            BRENDA, the Enzyme Database: 1.6.4.7
///
ENTRY       EC 1.6.4.8
NAME        Trypanothione reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADPH:trypanathione oxidoreductase
REACTION    NADPH + Trypanothione = NADP+ + Reduced trypanothione
SUBSTRATE   NADPH
            Trypanothione
PRODUCT     NADP+
            Reduced trypanothione
COFACTOR    FAD
COMMENT     Trypanothione is the oxidized form of N1,N6-bis(glutathionyl)-
            spermidine from the insect-parasitic trypanosomatid Crithidia
            fasciculata. The enzyme from Crithidia fasciculata is a
            flavoprotein (FAD), whose activity is dependent on a redox-active
            cystine at the active centre. (cf. EC 1.6.4.2)
MOTIF       PS: PS00076  G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P
STRUCTURES  PDB: 1AOG  1BZL  1FEA  1FEB  1FEC  1NDA  1TYP  1TYT  2TPR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.8
            ExPASy - ENZYME nomenclature database: 1.6.4.8
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.8
            BRENDA, the Enzyme Database: 1.6.4.8
            SCOP (Structural Classification of Proteins): 1.6.4.8
///
ENTRY       EC 1.6.4.9
NAME        Bis-gamma-glutamylcystine reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADPH:bis-gamma-glutamylcystine oxidoreductase
REACTION    NADPH + Bis-gamma-glutamylcystine = NADP+ + 2 gamma-Glutamylcysteine
SUBSTRATE   NADPH
            Bis-gamma-glutamylcystine
PRODUCT     NADP+
            gamma-Glutamylcysteine
COMMENT     Highly specific.  Not identical with EC 1.6.4.2 or 1.6.4.10.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.9
            ExPASy - ENZYME nomenclature database: 1.6.4.9
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.9
            BRENDA, the Enzyme Database: 1.6.4.9
///
ENTRY       EC 1.6.4.10
NAME        CoA-disulfide reductase (NADH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With disulfide as acceptor
SYSNAME     NADH:CoA-disulfide oxidoreductase
REACTION    NADH + CoA-disulfide = NAD+ + 2 CoA
SUBSTRATE   NADH
            CoA-disulfide
PRODUCT     NAD+
            CoA
COMMENT     Not identical with EC 1.6.4.1, 1.6.4.2 or 1.6.4.9.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.4.10
            ExPASy - ENZYME nomenclature database: 1.6.4.10
            WIT (What Is There) Metabolic Reconstruction: 1.6.4.10
            BRENDA, the Enzyme Database: 1.6.4.10
///
ENTRY       EC 1.6.5.1
NAME        Deleted entry
            Quinone reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.1
            ExPASy - ENZYME nomenclature database: 1.6.5.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.1
///
ENTRY       EC 1.6.5.2
NAME        Transferred to EC 1.6.99.2
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
COMMENT     Transferred entry. Now EC 1.6.99.2 - NAD(P)H dehydrogenase
            (quinone).
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.2
            ExPASy - ENZYME nomenclature database: 1.6.5.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.2
///
ENTRY       EC 1.6.5.3
NAME        NADH dehydrogenase (ubiquinone)
            Ubiquinone reductase
            Type I dehydrogenase
            Complex I dehydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
SYSNAME     NADH:ubiquinone oxidoreductase
REACTION    NADH + Ubiquinone = NAD+ + Ubiquinol
SUBSTRATE   NADH
            Ubiquinone
PRODUCT     NAD+
            Ubiquinol
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein (FAD) containing iron-sulfur contres. The complex,
            present in mitochondria, can be degraded to form EC 1.6.99.3.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
            PATH: MAP00190  Oxidative phosphorylation
GENES       ECO: b2276(nuoN) b2277(nuoM) b2278(nuoL) b2279(nuoK) b2280(nuoJ)
                 b2281(nuoI) b2282(nuoH) b2283(nuoG) b2284(nuoF) b2285(nuoE)
                 b2286 b2287(nuoB) b2288(nuoA)
            ECE: Z3534(nuoN) Z3536(nuoM) Z3537(nuoL) Z3538(nuoK) Z3539(nuoJ)
                 Z3540(nuoI) Z3541(nuoH) Z3542(nuoG) Z3543(nuoF) Z3544(nuoE)
                 Z3545(nuoC) Z3546(nuoB) Z3547(nuoA)
            ECS: ECs3160 ECs3161 ECs3162 ECs3163 ECs3164 ECs3165 ECs3166
                 ECs3167 ECs3168 ECs3169 ECs3170 ECs3171 ECs3172
            YPE: YPO2543(nuoN) YPO2544(nuoM) YPO2545(nuoL) YPO2546(nuoK)
                 YPO2547(nuoJ) YPO2548(nuoI) YPO2549(nuoH) YPO2550(nuoG)
                 YPO2551(nuoF) YPO2552(nuoE) YPO2553(nuoD) YPO2554(nuoB)
                 YPO2555(nuoA) YPO3235(nqrF) YPO3239(nqrB) YPO3240(nqrA)
            XFA: XF0305 XF0306 XF0307 XF0308 XF0309 XF0310 XF0311 XF0312
                 XF0313 XF0314 XF0315 XF0316 XF0317 XF0318
            VCH: VC1581 VCA0155 VCA0157
            PAE: PA1054 PA1056 PA1883 PA2637(nuoA) PA2638(nuoB) PA2639(nuoD)
                 PA2640(nuoE) PA2641(nuoF) PA2642(nuoG) PA2643(nuoH)
                 PA2644(nuoI) PA2645(nuoJ) PA2646(nuoK) PA2647(nuoL)
                 PA2648(nuoM) PA2649(nuoN)
            BUC: BU154(nuoA) BU155(nuoB) BU156(nuoCD) BU157(nuoE) BU158(nuoF)
                 BU159(nuoG) BU160(nuoH) BU161(nuoI) BU162(nuoJ) BU163(nuoK)
                 BU164(nuoL) BU165(nuoM) BU166(nuoN)
            NME: NMB0241 NMB0242 NMB0243 NMB0244 NMB0245 NMB0246 NMB0249
                 NMB0250 NMB0251 NMB0253 NMB0254 NMB0257 NMB0258 NMB0259
            NMA: NMA0002(nuoL) NMA0005(nuoK) NMA0006(nuoJ) NMA0008(nuoI)
                 NMA0009(nuoH) NMA0010(nuoG) NMA0014(nuoF) NMA0015(nuoE)
                 NMA0016(nuoD) NMA0017(nuoC) NMA0018(nuoB) NMA0019(nuoA)
                 NMA0747(nqrF) NMA2228(nuoN) NMA2229(nuoM)
            HPY: HP1260(NQO7) HP1261(NQO6) HP1262(NQO5) HP1263 HP1264 HP1265
                 HP1266(NQO3) HP1267(NQO8) HP1268(NQO9) HP1269(NQO10) HP1270
                 HP1271(NQO12) HP1272(NQO13) HP1273(NQO14)
            HPJ: jhp1181 jhp1182 jhp1183 jhp1184 jhp1185 jhp1186 jhp1187
                 jhp1188 jhp1189 jhp1190 jhp1191 jhp1192 jhp1193 jhp1194
            CJE: Cj1566c(nuoN) Cj1567c(nuoM) Cj1568c(nuoL) Cj1569c(nuoK)
                 Cj1570c(nuoJ) Cj1571c(nuoI) Cj1572c(nuoH) Cj1573c(nuoG)
                 Cj1574c Cj1575c Cj1576c(nuoD) Cj1577c(nuoC) Cj1578c(nuoB)
                 Cj1579c(nuoA)
            RPR: RP115(nuoF) RP282(nuoL3) RP283(nuoL2) RP284(nuoN2)
                 RP353(nuoE) RP354(nuoD) RP355(nuoC) RP356(nuoB) RP357(nuoA)
                 RP537(nuoN1) RP790(nuoJ) RP791(nuoK) RP792(nuoL1) RP793(nuoM)
                 RP795(nuoI) RP796(nuoH) RP797(nuoG)
            RCO: RC0155(nuoF) RC0378(nuoL3) RC0381(nuoL2) RC0382(nuoN2)
                 RC0481(nuoE) RC0482(nuoD) RC0483(nuoC) RC0484(nuoB)
                 RC0485(nuoA) RC0796(nuoN1) RC1224(nuoJ) RC1225(nuoK)
                 RC1226(nuoL1) RC1227(nuoM) RC1229(nuoI) RC1230(nuoH)
                 RC1231(nuoG)
            MLO: mll1352 mll1354 mll1355 mll1357 mll1358 mll1359 mll1361
                 mll1362 mll1364 mll1365 mll1366 mll1367 mll1369 mll1371
                 mll1372 mll5193 mlr3004
            SME: SMa1516(nuoH2) SMa1519 SMa1523(nuoG2) SMa1525(nuoF2)
                 SMa1526(nuoE2) SMa1529(nuoD2) SMa1531(nuoC2) SMa1532(nuoB2)
                 SMa1533(nuoA2) SMa1535(nuoN2) SMa1536(nuoM2) SMa1541
                 SMa1544(nuoK2) SMa1545 SMc00410 SMc01912(nuoA1)
                 SMc01913(nuoB1) SMc01914(nuoC1) SMc01915(nuoD1)
                 SMc01917(nuoE1) SMc01918(nuoF1) SMc01919 SMc01920(nuoG1)
                 SMc01921(nuoH) SMc01922(nuoI) SMc01923(nuoJ) SMc01924(nuoK1)
                 SMc01925(nuoL) SMc01926(nuoM) SMc01927(nuoN)
            ATU: AGR_C_1658 AGR_C_1663 AGR_C_2340 AGR_C_2341 AGR_C_2342(nuoC1)
                 AGR_C_2346 AGR_C_2348 AGR_C_2350 AGR_C_2353 AGR_C_2354
                 AGR_C_2355 AGR_C_2357 AGR_C_2359 AGR_C_2360 AGR_C_2362
                 AGR_C_2364 AGR_C_511 AGR_C_903
            CCR: CC1937 CC1938 CC1939 CC1940 CC1941 CC1942 CC1945 CC1946
                 CC1947 CC1950 CC1952 CC1954 CC1955 CC1956 CC3604
            BSU: BG10949(ndhF) BG12355(mrpA)
            SAU: SA0411(ndhF) SA0578
            SAV: SAV0440(ndhF) SAV0611
            MTU: Rv3145(nuoA) Rv3146(nuoB) Rv3147(nuoC) Rv3148(nuoD)
                 Rv3149(nuoE) Rv3150(nuoF) Rv3151(nuoG) Rv3152(nuoH)
                 Rv3153(nuoI) Rv3154(nuoJ) Rv3155(nuoK) Rv3156(nuoL)
                 Rv3157(nuoM) Rv3158(nuoN)
            MTC: MT3233 MT3234 MT3235 MT3236 MT3237 MT3238 MT3239 MT3240
                 MT3241 MT3242 MT3243 MT3244 MT3245 MT3246
            SYN: sll0026(ndhF) sll0027(ndhD4) sll0223(ndhB) sll0519(ndhA)
                 sll0520(ndhI) sll0521(ndhG) sll0522(ndhE) sll1220
                 sll1221(hoxF) sll1223(hoxU) sll1732(ndhF) sll1733(ndhD3)
                 slr0261(ndhH) slr0331(ndhD1) slr0844(ndhF) slr1279(ndhC)
                 slr1280(psbg1) slr1281(ndhJ) slr1291(ndhD2) slr2007(ndhD5)
                 slr2009(ndhD6)
            DRA: DR0880 DR1492 DR1493 DR1494 DR1495 DR1496 DR1497 DR1498
                 DR1499 DR1500 DR1501 DR1503 DR1504 DR1505 DR1506 DR1980
            AAE: aq_1310(nuoA2) aq_1312(nuoB) aq_1314(nuoD2) aq_1315(nuoH1)
                 aq_1317(nuoI1) aq_1318(nuoJ1) aq_1319(nuoK1) aq_1320(nuoL1)
                 aq_1321(nuoM1) aq_1322(nuoN1) aq_135(nueM) aq_1373(nuoH2)
                 aq_1374(nuoH3) aq_1375(nuoI2) aq_1377(nuoJ2) aq_1378(nuoK2)
                 aq_1379(nuoL3) aq_1382(nuoM2) aq_1383(nuoN2) aq_1385(nuoA1)
                 aq_437(nuoG) aq_551(nuoD1) aq_573(nuoF) aq_574(nuoE)
                 aq_866(nuoL2)
            TMA: TM0010 TM0011 TM0012 TM0201 TM0228 TM1105 TM1211 TM1212
                 TM1213 TM1214 TM1215 TM1216 TM1424 TM1425 TM1426
            MJA: MJ0520 MJ1309(cooM) MJ1362
            MTH: MTH1237 MTH1246 MTH1548 MTH1549 MTH393
            AFU: AF1823 AF1824 AF1825(nuoM) AF1826(nuoL) AF1827 AF1828 AF1829
                 AF1830(nuoD) AF1831
            HAL: VNG0560C VNG0562C VNG0563G(ndhG2) VNG0635G(nolB)
                 VNG0636G(ndhG1) VNG0637G(ndhG5) VNG0639G(ndhG4) VNG0640G(nolD)
                 VNG0641C VNG0643G(nolC) VNG0646G(nuoL) VNG0647G(nuoM)
                 VNG0648G(ndhG3) VNG1932G(nolA)
            TAC: Ta0959 Ta0960 Ta0961 Ta0962 Ta0964 Ta0965 Ta0966 Ta0967
                 Ta0968 Ta0969 Ta0970
            TVO: TVG1157047 TVG1158465 TVG1160017 TVG1161017 TVG1162018
                 TVG1162541 TVG1162786 TVG1163214 TVG1164251 TVG1165354
                 TVG1165809 TVG1166270
            PHO: PH0941 PH0942 PH1431 PH1446 PH1447 PH1448 PH1449 PH1450
                 PH1451 PH1452 PH1453
            PAB: PAB0488 PAB0490(nuoM) PAB0492(nuoH) PAB0493(nuoB)
                 PAB0494(nuoC) PAB0495(nuoD) PAB0496(nuoI) PAB0805 PAB0806
                 PAB1888 PAB2416(nuoN)
            APE: APE1410 APE1411 APE1415 APE1417 APE1418 APE1419 APE1421
                 APE1422 APE1426 APE1428 APE1430
            SSO: SSO0322(NuoA) SSO0323(NuoC) SSO0324(NuoD) SSO0325(NuoH)
                 SSO0326(NuoI) SSO0327(NuoJ) SSO0328(NuoL) SSO0329(NuoN)
                 SSO0665(NuoB)
            STO: ST1527 ST2216 ST2217 ST2218 ST2219 ST2220 ST2221 ST2222
                 ST2223
            SCE: YKL192C(ACP1)
            SPO: SPAC11E3.12(spac11e3.12) SPAC4H3.09(spac4h3.09)
                 SPBC18E5.10(spbc18e5.10)
            ATH: At1g16700(F19K19.1) At1g65290(T8F5.6) At1g79010(YUP8H12R.37)
                 At1g79200(YUP8H12R.41) At2g02050(F14H20.12) At2g20360(F11A3.9)
                 At2g44620(F16B22.28) At4g02580(T10P11.14) At5g08530(MAH20.9)
                 At5g11770(T22P22.160) At5g37510(MPA22.5)
            CEL: C09H10.3 C16A3.4 C18E9.4 C25A1.13 C33A12.1 D2030.4 F16B4.6
                 F22D6.4 F37C12.3 F44G4.2 F53F4.10 F59C6.5 K04G7.4
                 K09A9.5(gas-1) T10E9.7 T20H4.5 T26A5.3 W10D5.2 Y51H1A.3a
                 Y51H1A.3b Y57G11C.12 Y63D3A.7
            DME: CG10320 CG11423 CG11913 CG12079 CG15434 CG1970 CG2014
                 CG2286(ND75) CG3192 CG3621(EG:152A3.7) CG3683 CG3944 CG5548
                 CG5703 CG6020 CG6343(ND42) CG6463 CG6485 CG6914 CG7712 CG8102
                 CG8844 CG9140 CG9160(mtacp1) CG9160_1(mtacp1) CG9172 CG9306
                 CG9762
            HSA: 4535(MTND1) 4536(MTND2) 4537(MTND3) 4538(MTND4) 4539(MTND4L)
                 4540(MTND5) 4541(MTND6) 4694(NDUFA1) 4695(NDUFA2) 4696(NDUFA3)
                 4697(NDUFA4) 4698(NDUFA5) 4700(NDUFA6) 4701(NDUFA7)
                 4702(NDUFA8) 4704(NDUFA9) 4705(NDUFA10) 4706(NDUFAB1)
                 4707(NDUFB1) 4708(NDUFB2) 4709(NDUFB3) 4710(NDUFB4)
                 4711(NDUFB5) 4712(NDUFB6) 4713(NDUFB7) 4714(NDUFB8)
                 4715(NDUFB9) 4716(NDUFB10) 4717(NDUFC1) 4718(NDUFC2)
                 4719(NDUFS1) 4720(NDUFS2) 4722(NDUFS3) 4723(NDUFV1)
                 4724(NDUFS4) 4725(NDUFS5) 4726(NDUFS6) 4727(NDUFS7)
                 4728(NDUFS8) 4729(NDUFV2)
DISEASE     MIM: 300078  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1,
                         7.5kD
            MIM: 601677  NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
                         (13kD, B13)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00535  [LIVMH]-H-[RT]-[GA]-x-E-K-[LIVMTN]-x-E-x-[KRQ]
            PS: PS00542  E-R-E-x(2)-[DE]-[LIVMFY](2)-x(6)-[HK]-x(3)-[KRP]-x-
                         [LIVM]-[LIVMYS]
            PS: PS00641  P-x(2)-C-[YWSD]-x(7)-G-x-C-R-x-C
            PS: PS00642  C-P-x-C-[DE]-x-[GS](2)-x-C-x-L-Q
            PS: PS00643  R-C-[LIVM]-x-C-x-R-C-[LIVMT]-x-[LMFY]
            PS: PS00644  G-[AM]-G-[AR]-Y-[LIVM]-C-G-[DE](2)-[STA](2)-[LIM](2)-
                         [END]-S
            PS: PS00645  E-[ST]-C-G-x-C-x-P-C-R-x-G
            PS: PS00667  G-[LIVMFYKRS]-[LIVMAGP]-Q-x-[LIVMFY]-x-D-[AGIM]-
                         [LIVMFTA]-K-[LVMYST]-[LIVMFYG]-x-[KR]-[EQG]
            PS: PS00668  P-F-D-[LIVMFYQ]-[STAGPVM]-E-[GAC]-E-x-[EQ]-[LIVMS]-
                         x(2)-G
            PS: PS01099  D-x(2)-F-[STK]-x(5)-C-[LM]-G-x-C-x(2)-[GA]-P
            PS: PS01150  [GN]-x-D-[KRHST]-[LIVMF](2)-P-[IV]-D-[LIVMFYW](2)-x-P-
                         x-C-P-[PT]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.3
            ExPASy - ENZYME nomenclature database: 1.6.5.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.3
            BRENDA, the Enzyme Database: 1.6.5.3
///
ENTRY       EC 1.6.5.4
NAME        Monodehydroascorbate reductase (NADH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
SYSNAME     NADH:monodehydroascorbate oxidoreductase
REACTION    NADH + 2 Monodehydroascorbate = NAD+ + 2 Ascorbate
SUBSTRATE   NADH
            Monodehydroascorbate
PRODUCT     NAD+
            Ascorbate
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.4
            ExPASy - ENZYME nomenclature database: 1.6.5.4
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.4
            BRENDA, the Enzyme Database: 1.6.5.4
///
ENTRY       EC 1.6.5.5
NAME        NADPH:Quinone reductase
            Quinone oxidoreductase
            Zeta-crystallin
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
REACTION    NADPH + Quinone = NADP+ + Semiquinone
SUBSTRATE   NADPH
            Quinone
PRODUCT     NADP+
            Semiquinone
COMMENT     Specific for NADPH. Catalyses the one election reduction of certain
            quinones substrate.
            Dicoumarol (Cf EC 1.6.99.2) and nitrofurantoin are competitive
            inhibitors with respect to the Quinone substrate.
            Abundance in the lens of the eye in mammalian species.
GENES       ECO: b4051(qor)
            ECE: Z5649(qor)
            ECS: ECs5033
            YPE: YPO0319(qor)
            VCH: VC0552
            PAE: PA0023(qor) PA2680 PA5234
            MLO: mll0505 mll2594
            SME: SMb20388 SMb21290 SMc00246(qor)
            CCR: CC0096 CC3759
            BHA: BH0363 BH0935
            MTU: Rv0149 Rv1454c(qor) Rv3141(fadB4)
            MTC: MT0157 MT1501 MT3228
            DRA: DR1061 DRA0251
            AFU: AF1833
            SCE: YBR046C(ZTA1)
            SPO: SPCC1442.16C
            CEL: F39B2.3
            HSA: 1429(CRYZ)
DISEASE     MIM: 123691  Crystallin, zeta (quinone reductase)
MOTIF       PS: PS01162  [GSD]-[DEQH]-x(2)-L-x(3)-[SA](2)-G-G-x-G-x(4)-Q-x(2)-
                         [KR]
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.5
            ExPASy - ENZYME nomenclature database: 1.6.5.5
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.5
///
ENTRY       EC 1.6.5.6
NAME        p-Benzoquinone reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With quinone or related compound as acceptor
SYSNAME     NADPH:p-benzoquinone oxidoreductase
REACTION    NADPH + p-Benzoquinone = NADP + Hydroquinone
SUBSTRATE   NADPH
            p-Benzoquinone
PRODUCT     NADP
            Hydroquinone
COMMENT     Involved in the 4-nitrophenol degradation pathway in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.5.6
            ExPASy - ENZYME nomenclature database: 1.6.5.6
            WIT (What Is There) Metabolic Reconstruction: 1.6.5.6
            UM-BBD (Biocatalysis/Biodegradation Database): 1.6.5.6
///
ENTRY       EC 1.6.6.1
NAME        Nitrate reductase (NADH)
            Assimilatory nitrate reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADH:nitrate oxidoreductase
REACTION    NADH + Nitrate = NAD+ + Nitrite + H2O
SUBSTRATE   NADH
            Nitrate
PRODUCT     NAD+
            Nitrite
            H2O
COFACTOR    FAD
            FMN
            Molybdenum
COMMENT     A flavoprotein (FAD or FMN) containing a molybdenum.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       ATH: At1g37130(F28L22.2) At1g77760(T32E8.9)
MOTIF       PS: PS00191  [FY]-[LIVMK]-x(2)-H-P-[GA]-G
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
STRUCTURES  PDB: 1CNE  1CNF  2CND  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.1
            ExPASy - ENZYME nomenclature database: 1.6.6.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.1
            BRENDA, the Enzyme Database: 1.6.6.1
            SCOP (Structural Classification of Proteins): 1.6.6.1
///
ENTRY       EC 1.6.6.2
NAME        Nitrate reductase (NAD(P)H)
            Assimilatory nitrate reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NAD(P)H:nitrate oxidoreductase
REACTION    NADH + Nitrate = NAD+ + Nitrite + H2O;
            NADPH + Nitrate = NADP+ + Nitrite + H2O
SUBSTRATE   NADPH
            NADH
            Nitrate
PRODUCT     NADP+
            NAD+
            Nitrite
            H2O
COFACTOR    FAD
            FMN
COMMENT     A flavoprotein (FAD or FMN).
PATHWAY     PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00191  [FY]-[LIVMK]-x(2)-H-P-[GA]-G
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.2
            ExPASy - ENZYME nomenclature database: 1.6.6.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.2
            BRENDA, the Enzyme Database: 1.6.6.2
///
ENTRY       EC 1.6.6.3
NAME        Nitrate reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADPH:nitrate oxidoreductase
REACTION    NADPH + Nitrate = NADP+ + Nitrite + H2O
SUBSTRATE   NADPH
            Nitrate
PRODUCT     NADP+
            Nitrite
            H2O
COFACTOR    FAD
            Molybdenum
COMMENT     A flavoprotein (FAD) containing molybdenum.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00191  [FY]-[LIVMK]-x(2)-H-P-[GA]-G
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.3
            ExPASy - ENZYME nomenclature database: 1.6.6.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.3
            BRENDA, the Enzyme Database: 1.6.6.3
///
ENTRY       EC 1.6.6.4
NAME        Nitrite reductase (NAD(P)H)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NAD(P)H:nitrite oxidoreductase
REACTION    3 NADH + Nitrite = 3 NAD+ + NH4OH + H2O;
            3 NADPH + Nitrite = 3 NADP+ + NH4OH + H2O
SUBSTRATE   NADPH
            NADH
            Nitrite
PRODUCT     NADP+
            NAD+
            NH4OH
            H2O
COFACTOR    FAD
            Siroheme
            Iron
COMMENT     A flavoprotein containing a siroheme and non-heme iron.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b3365(nirB) b3366(nirD)
            ECE: Z4726(nirB) Z4727(nirD)
            ECS: ECs4216 ECs4217
            YPE: YPO0160(nirD) YPO0161(nirB)
            PAE: PA1780(nirD) PA1781(nirB)
            MLO: mlr2862 mlr2863
            SME: SMb20984(nirB) SMb20985(nirD)
            CCR: CC0615 CC0616
            BSU: BG11094(nasB) BG11096(nasD) BG11097(nasE)
            BHA: BH0613(nasD) BH0614(nasE)
            SAU: SA2187(nasE) SA2188(nasD)
            SAV: SAV2383(nasE) SAV2384(nasD)
            MTU: Rv0252(nirB) Rv0253
            MTC: MT0266
            AAE: aq_206(nirB)
MOTIF       PS: PS00365  [STV]-G-C-x(3)-C-x(6)-[DE]-[LIVMF]-[GAT]-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.4
            ExPASy - ENZYME nomenclature database: 1.6.6.4
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.4
            BRENDA, the Enzyme Database: 1.6.6.4
///
ENTRY       EC 1.6.6.5
NAME        Transferred to EC 1.7.99.3
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
COMMENT     Transferred entry. Now EC 1.7.99.3 - Nitrite reductase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.5
            ExPASy - ENZYME nomenclature database: 1.6.6.5
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.5
///
ENTRY       EC 1.6.6.6
NAME        Hyponitrite reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADH:hyponitrite oxidoreductase
REACTION    2 NADH + Hyponitrite = 2 NAD+ + 2 Hydroxylamine
SUBSTRATE   NADH
            Hyponitrite
PRODUCT     NAD+
            Hydroxylamine
COFACTOR    Metal
COMMENT     A metalloprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.6
            ExPASy - ENZYME nomenclature database: 1.6.6.6
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.6
            BRENDA, the Enzyme Database: 1.6.6.6
///
ENTRY       EC 1.6.6.7
NAME        Azobenzene reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADPH:4-(dimethylamino)azobenzene oxidoreductase
REACTION    NADPH + 4-(Dimethylamino)azobenzene = NADP+ +
            N,N-Dimethyl-1,4-phenylenediamine + Aniline
SUBSTRATE   NADPH
            4-(Dimethylamino)azobenzene
PRODUCT     NADP+
            N,N-Dimethyl-1,4-phenylenediamine
            Aniline
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.7
            ExPASy - ENZYME nomenclature database: 1.6.6.7
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.7
            BRENDA, the Enzyme Database: 1.6.6.7
///
ENTRY       EC 1.6.6.8
NAME        GMP reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADH:guanosine-5'-phosphate oxidoreductase(deaminating)
REACTION    NADPH + Guanosine 5'-phosphate = NADP+ + Inosine 5'-phosphate +
            NH3
SUBSTRATE   NADPH
            Guanosine 5'-phosphate
PRODUCT     NADP+
            Inosine 5'-phosphate
            NH3
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0104(guaC)
            ECE: Z0114(guaC)
            ECS: ECs0108
            YPE: YPO3428(guaC)
            VCH: VCA0197
            BUC: BU204(guaC)
            HPY: HP0854(guaC)
            HPJ: jhp0790
            BSU: BG12392(guaC)
            SAU: SA1172
            SAV: SAV1322
            LLA: L158186(guaC)
            SPY: SPy1135
            SPN: SP1249
            CAC: CAC3471
            CEL: F32D1.5
            HSA: 2766(GMPR) 51292(LOC51292)
DISEASE     MIM: 139265  Guanine monophosphate reductase
MOTIF       PS: PS00487  [LIVM]-[RK]-[LIVM]-G-[LIVM]-G-x-G-S-[LIVM]-C-x-T
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.8
            ExPASy - ENZYME nomenclature database: 1.6.6.8
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.8
            BRENDA, the Enzyme Database: 1.6.6.8
///
ENTRY       EC 1.6.6.9
NAME        Trimethylamine-N-oxide reductase
            Trimethylamine oxidase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADH:trimethylamine-N-oxide oxidoreductase
REACTION    NADH + Trimethylamine N-oxide = NAD+ + Trimethylamine + H2O
SUBSTRATE   NADH
            Trimethylamine N-oxide
PRODUCT     NAD+
            Trimethylamine
            H2O
PATHWAY     PATH: MAP00680  Methane metabolism
GENES       ECO: b0997(torA)
            ECE: Z1415(torA)
            ECS: ECs1152
            PMU: PM1793(torA)
            VCH: VC1692
MOTIF       PS: PS00490  [STA]-x-[STAC](2)-x(2)-[STA]-D-[LIVMY](2)-L-P-x-
                         [STAC](2)-x(2)-E
            PS: PS00551  [STAN]-x-[CH]-x(2,3)-C-[STAG]-[GSTVMF]-x-C-x-[LIVMFYW]-
                         x-[LIVMA]-x(3,4)-[DENQKHT]
            PS: PS00932  A-x(3)-[GDT]-I-x-[DNQTK]-x-[DEA]-x-[LIVM]-x-[LIVMC]-x-
                         [NS]-x(2)-[GS]-x(5)-A-x-[LIVM]-[ST]
STRUCTURES  PDB: 1TMO  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.9
            ExPASy - ENZYME nomenclature database: 1.6.6.9
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.9
            BRENDA, the Enzyme Database: 1.6.6.9
            SCOP (Structural Classification of Proteins): 1.6.6.9
///
ENTRY       EC 1.6.6.10
NAME        Nitroquinoline-N-oxide reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase
REACTION    2 NADH or 2 NADPH + 4-Nitroquinoline N-oxide = 2 NAD+ or 2 NADP+ +
            4-Hydroxyaminoquinoline N-oxide
SUBSTRATE   NADH
            NADPH
            4-Nitroquinoline N-oxide
PRODUCT     NAD+
            NADP+
            4-Hydroxyaminoquinoline N-oxide
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.10
            ExPASy - ENZYME nomenclature database: 1.6.6.10
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.10
            BRENDA, the Enzyme Database: 1.6.6.10
///
ENTRY       EC 1.6.6.11
NAME        Hydroxylamine reductase (NADH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADH:hydroxylamine oxidoreductase
REACTION    NADH + Hydroxylamine = NAD+ + NH3 + H2O
SUBSTRATE   NADH
            Hydroxylamine
PRODUCT     NAD+
            NH3
            H2O
COMMENT     Also acts on some hydroxamates.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.11
            ExPASy - ENZYME nomenclature database: 1.6.6.11
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.11
            BRENDA, the Enzyme Database: 1.6.6.11
///
ENTRY       EC 1.6.6.12
NAME        4-(Dimethylamino)phenylazoxybenzene reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase
REACTION    NADPH + 4-(Dimethylamino)phenylazoxybenzene = NADP+ +
            4-(Dimethylamino)phenylazobenzene
SUBSTRATE   NADPH
            4-(Dimethylamino)phenylazoxybenzene
PRODUCT     NADP+
            4-(Dimethylamino)phenylazobenzene
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.12
            ExPASy - ENZYME nomenclature database: 1.6.6.12
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.12
            BRENDA, the Enzyme Database: 1.6.6.12
///
ENTRY       EC 1.6.6.13
NAME        N-Hydroxy-2-acetamidofluorene reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a nitrogenous group as acceptor
SYSNAME     NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase
REACTION    NADH or NADPH + N-Hydroxy-2-acetamidofluorene = NAD+ or NADP+ +
            2-Acetamidofluorene + H2O
SUBSTRATE   NADH
            NADPH
            N-Hydroxy-2-acetamidofluorene
PRODUCT     NAD+
            NADP+
            2-Acetamidofluorene
            H2O
COMMENT     Also acts, more slowly, on N-hydroxy-4-acetamidobiphenyl.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.6.13
            ExPASy - ENZYME nomenclature database: 1.6.6.13
            WIT (What Is There) Metabolic Reconstruction: 1.6.6.13
            BRENDA, the Enzyme Database: 1.6.6.13
///
ENTRY       EC 1.6.7.1
NAME        Transferred to EC 1.18.1.2
CLASS       Oxidoreductases
            Acting on NADH or NADPH
COMMENT     Transferred entry. Now EC 1.18.1.2 - Ferredoxin--NADP+ reductase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.7.1
            ExPASy - ENZYME nomenclature database: 1.6.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.7.1
///
ENTRY       EC 1.6.7.2
NAME        Transferred to EC 1.18.1.1
CLASS       Oxidoreductases
            Acting on NADH or NADPH
COMMENT     Transferred entry. Now EC 1.18.1.1 - Rubredoxin--NAD+ reductase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.7.2
            ExPASy - ENZYME nomenclature database: 1.6.7.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.7.2
///
ENTRY       EC 1.6.8.1
NAME        NAD(P)H dehydrogenase (FMN)
            FMN reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a flavin as acceptor
SYSNAME     NAD(P)H:riboflavin oxidoreductase
REACTION    NADPH + Riboflavin = NADP+ + Reduced riboflavin
SUBSTRATE   NADPH
            Riboflavin
PRODUCT     NADP+
            Reduced riboflavin
COMMENT     The enzyme, from luminescent bacteria, also reduces riboflavin and
            FAD, more slowly.
GENES       ECO: b0937(ycbP)
            ECE: Z1285(ycbP)
            ECS: ECs1020
            YPE: YPO3623(ssuE)
            PAE: PA2357(msuE)
            MLO: mlr5227
            SME: SMb20573
            BHA: BH3321(ssuE)
            SAU: SA0328
            SAV: SAV0329
STRUCTURES  PDB: 1BKJ  1VFR  2BKJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.8.1
            ExPASy - ENZYME nomenclature database: 1.6.8.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.8.1
            BRENDA, the Enzyme Database: 1.6.8.1
            SCOP (Structural Classification of Proteins): 1.6.8.1
///
ENTRY       EC 1.6.8.2
NAME        NADPH dehydrogenase (flavin)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With a flavin as acceptor
SYSNAME     NADPH:riboflavin oxidoreductase
REACTION    NADPH + Riboflavin = NADP+ + Reduced riboflavin
SUBSTRATE   NADPH
            Riboflavin
PRODUCT     NADP+
            Reduced riboflavin
COMMENT     The enzyme from Entamoeba histolytica reduces riboflavin and
            galactoflavin, and, more slowly, FMN and FAD.  NADH is oxidized
            at one-twentieth of the rate of NADPH.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.8.2
            ExPASy - ENZYME nomenclature database: 1.6.8.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.8.2
            BRENDA, the Enzyme Database: 1.6.8.2
///
ENTRY       EC 1.6.99.1
NAME        NADPH dehydrogenase
            NADPH diaphorase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADPH:(acceptor) oxidoreductase
REACTION    NADPH + Acceptor = NADP+ + Reduced acceptor
SUBSTRATE   NADPH
            Acceptor
PRODUCT     NADP+
            Reduced acceptor
COFACTOR    FMN
            FAD
COMMENT     A flavoprotein (FMN in yeast, FAD in plants).
GENES       SCE: YHR179W(OYE2) YPL171C(OYE3)
            SPO: SPAC5H10.04(spac5h10.04) SPAC5H10.10(spac5h10.10)
            CEL: F17A9.5
            HSA: 645(BLVRB)
STRUCTURES  PDB: 1BWK  1BWL  1HDO  1HE2  1HE3  1HE4  1HE5  1K02  1K03  1OYA  
                 1OYB  1OYC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.1
            ExPASy - ENZYME nomenclature database: 1.6.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.1
            BRENDA, the Enzyme Database: 1.6.99.1
            SCOP (Structural Classification of Proteins): 1.6.99.1
///
ENTRY       EC 1.6.99.2
NAME        NAD(P)H dehydrogenase (quinone)
            Menadione reductase
            Phylloquinone reductase
            Quinone reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NAD(P)H:(quinone-acceptor) oxidoreductase
REACTION    NADH or NADPH + Acceptor = NAD+ or NADP+ + Reduced acceptor
SUBSTRATE   NADPH
            NADH
            Acceptor
PRODUCT     NADP+
            NAD+
            Reduced acceptor
INHIBITOR   Dicoumarol
COFACTOR    FAD
COMMENT     A flavoprotein. Inhibited by dicoumarol.
            Formerly EC 1.6.5.2.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       PAE: PA4975
            MLO: mll7814
            SME: SMc03185
            MMU: 103187(Nmor1)
            HSA: 1728(DIA4) 4835(NMOR2)
DISEASE     MIM: 160998  NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2
STRUCTURES  PDB: 1H66  1D4A  1DXO  1DXQ  1GG5  1H69  1QBG  1QR2  1QRD  2QR2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.2
            ExPASy - ENZYME nomenclature database: 1.6.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.2
            BRENDA, the Enzyme Database: 1.6.99.2
            SCOP (Structural Classification of Proteins): 1.6.99.2
///
ENTRY       EC 1.6.99.3
NAME        NADH dehydrogenase
            Cytochrome c reductase
            Type I dehydrogenase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADH:(acceptor) oxidoreductase
REACTION    NADH + Acceptor = NAD+ + Reduced acceptor
SUBSTRATE   NADH
            Acceptor
PRODUCT     NAD+
            Reduced acceptor
COFACTOR    FAD
            Iron
            Sulfur
COMMENT     A flavoprotein containing iron-sulfur centres. After preparations
            have been subjected to certain treatments cytochrome c may act as
            acceptor. Formerly EC 1.6.2.1; present in a mitochondrial complex
            as EC 1.6.5.3.
GENES       ECO: b1109(ndh)
            ECE: Z1748(ndh)
            ECS: ECs1487
            YPE: YPO1617(ndh)
            HIN: HI0747(ndh)
            VCH: VC1890
            PAE: PA2691 PA4538(ndh)
            MLO: mll5193 mlr0365
            SME: SMb20861 SMc00410 SMc04452(ndh)
            ATU: AGR_C_3667 AGR_C_511
            CCR: CC3604
            BSU: BG12390(yumB) BG13203(yjlD)
            BHA: BH3407 BH3415
            SAU: SA0799 SA0802
            SAV: SAV0925 SAV0928
            LLA: L39857(noxA) L41335(noxB)
            MGE: MG275(nox)
            MPN: F11_orf479(nox)
            MPU: MYPU_0230(nox)
            MTU: Rv0392c Rv1812c Rv1854c(ndh)
            MTC: MT0403 MT1860 MT1902
            MLE: ML2061
            SYN: sll1484(ndbC) slr0851(ndbA) slr1743(ndbB)
            DRA: DR0950 DR1980
            AAE: aq_788
            HAL: VNG0891G(yjlD) VNG1932G(nolA)
            SSO: SSO1010 SSO2960
            STO: ST2573
            SCE: YDL085W(NDH2) YKL192C(ACP1) YML120C(NDI1) YMR145C(NDH1)
            SPO: SPAC3A11.07(spac3a11.07) SPAC4H3.09(spac4h3.09)
                 SPBC947.15C(spbc947.15c)
            ATH: At1g07180(F10K1.11) At1g65290(T8F5.6) At1g79010(YUP8H12R.37)
                 At2g02050(F14H20.12) At2g20360(F11A3.9) At2g20800(F5H14.23)
                 At2g29990(F23F1.9) At2g44620(F16B22.28) At4g05020(T32N4.4)
                 At4g21490(F18E5.110) At4g28220(F26K10.100)
                 At5g11770(T22P22.160)
            CEL: C16A3.4 C18E9.4 C25A1.13 C33A12.1 D2030.4 F16B4.6 F22D6.4
                 F37C12.3 F44G4.2 F59C6.5 K09A9.5(gas-1) T20H4.5 W10D5.2
                 Y51H1A.3a Y51H1A.3b Y57G11C.12 Y63D3A.7
            DME: CG10320 CG15434 CG3192 CG3683 CG5548 CG6020 CG6463 CG7712
                 CG8844 CG9160(mtacp1) CG9160_1(mtacp1) CG9306 CG9762
            HSA: 4695(NDUFA2) 4696(NDUFA3) 4697(NDUFA4) 4698(NDUFA5)
                 4700(NDUFA6) 4701(NDUFA7) 4702(NDUFA8) 4704(NDUFA9)
                 4705(NDUFA10) 4706(NDUFAB1) 4707(NDUFB1) 4708(NDUFB2)
                 4709(NDUFB3) 4710(NDUFB4) 4711(NDUFB5) 4712(NDUFB6)
                 4713(NDUFB7) 4714(NDUFB8) 4715(NDUFB9) 4716(NDUFB10)
                 4717(NDUFC1) 4718(NDUFC2) 4719(NDUFS1) 4722(NDUFS3)
                 4723(NDUFV1) 4724(NDUFS4) 4725(NDUFS5) 4726(NDUFS6)
                 4727(NDUFS7) 4728(NDUFS8) 4729(NDUFV2) 4731(NDUFV3)
                 55967(LOC55967)
DISEASE     MIM: 157655  NADH dehydrogenase (ubiquinone), Fe-S protein-1, 75kD
            MIM: 161015  NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kD
            MIM: 600532  NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kD
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00535  [LIVMH]-H-[RT]-[GA]-x-E-K-[LIVMTN]-x-E-x-[KRQ]
            PS: PS00542  E-R-E-x(2)-[DE]-[LIVMFY](2)-x(6)-[HK]-x(3)-[KRP]-x-
                         [LIVM]-[LIVMYS]
            PS: PS00573  C-x(2)-C-D-[GA]-x(2,4)-[FY]-x(4)-[LIVM]-x-[LIVM](2)-
                         G(3)-[DN]
            PS: PS00641  P-x(2)-C-[YWSD]-x(7)-G-x-C-R-x-C
            PS: PS00642  C-P-x-C-[DE]-x-[GS](2)-x-C-x-L-Q
            PS: PS00643  R-C-[LIVM]-x-C-x-R-C-[LIVMT]-x-[LMFY]
            PS: PS00644  G-[AM]-G-[AR]-Y-[LIVM]-C-G-[DE](2)-[STA](2)-[LIM](2)-
                         [END]-S
            PS: PS00645  E-[ST]-C-G-x-C-x-P-C-R-x-G
            PS: PS01099  D-x(2)-F-[STK]-x(5)-C-[LM]-G-x-C-x(2)-[GA]-P
            PS: PS01150  [GN]-x-D-[KRHST]-[LIVMF](2)-P-[IV]-D-[LIVMFYW](2)-x-P-
                         x-C-P-[PT]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
STRUCTURES  PDB: 1NOX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.3
            ExPASy - ENZYME nomenclature database: 1.6.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.3
            BRENDA, the Enzyme Database: 1.6.99.3
            SCOP (Structural Classification of Proteins): 1.6.99.3
///
ENTRY       EC 1.6.99.4
NAME        Transferred to EC 1.18.1.2
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
COMMENT     Transferred entry. Now EC 1.18.1.2 - Ferredoxin--NADP+ reductase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.4
            ExPASy - ENZYME nomenclature database: 1.6.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.4
///
ENTRY       EC 1.6.99.5
NAME        NADH dehydrogenase (quinone)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADH:(quinone-acceptor) oxidoreductase
REACTION    NADH + Acceptor = NAD+ + Reduced acceptor
SUBSTRATE   NADH
            Acceptor
            Menaquinone
PRODUCT     NAD+
            Reduced acceptor
INHIBITOR   AMP
            2,4-Dinitrophenol
COMMENT     Menaquinone can act as acceptor.  Inhibited by AMP and
            2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.5
            ExPASy - ENZYME nomenclature database: 1.6.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.5
            BRENDA, the Enzyme Database: 1.6.99.5
///
ENTRY       EC 1.6.99.6
NAME        NADPH dehydrogenase (quinone)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADPH:(quinone-acceptor) oxidoreductase
REACTION    NADPH + Acceptor = NADP+ + Reduced acceptor
SUBSTRATE   NADPH
            Acceptor
            Menaquinone
PRODUCT     NADP+
            Reduced acceptor
INHIBITOR   Dicoumarol
            Folic acid
COFACTOR    FAD
COMMENT     A flavoprotein.  Menaquinone can act as acceptor.  Inhibited by
            dicoumarol and folic acid derivatives but not by
            2,4-dinitrophenol.
STRUCTURES  PDB: 1F5V  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.6
            ExPASy - ENZYME nomenclature database: 1.6.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.6
            BRENDA, the Enzyme Database: 1.6.99.6
            SCOP (Structural Classification of Proteins): 1.6.99.6
///
ENTRY       EC 1.6.99.7
NAME        Dihydropteridine reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NAD(P)H:6,7-dihydropteridine oxidoreductase
REACTION    NADH or NADPH + 6,7-Dihydrobiopterin = NAD+ or NADP+ +
            5,6,7,8-Tetrahydrobiopterin
SUBSTRATE   NADPH
            NADH
            6,7-Dihydrobiopterin
PRODUCT     NADP+
            NAD+
            5,6,7,8-Tetrahydrobiopterin
COMMENT     The substrate is the quinoid form of dihydrobiopterin. Not
            identical with EC 1.5.1.3.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2552(hmpA)
            ECE: Z3828(hmpA)
            ECS: ECs3418
            YPE: YPO2908(hmp)
            XFA: XF0053
            VCH: VCA0183
            PAE: PA2664(fhp)
            BSU: BG11418(hmp)
            BHA: BH1058(hmp)
            SAU: SA0231
            SAV: SAV0233(hmp)
            DRA: DRA0243
            AAE: aq_211(fhp)
            SCE: YGR234W(YHB1)
            SPO: SPAC869.02C(spac869.02c)
            DME: CG4665
            HSA: 5860(QDPR)
DISEASE     MIM: 261630  Quinoid dihydropteridine reductase
MOTIF       PS: PS00061  [LIVSPADNK]-x(12)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-
                         {PC}-[SAGFYR]-[LIVMSTAGD]-x(2)-[LIVMFYW]-x(3)-
                         [LIVMFYWGAPTHQ]-[GSACQRHM]
            PS: PS01033  Globins profile
STRUCTURES  PDB: 1DIR  1DS7  1HDR  1ICR  1ICU  1ICV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.7
            ExPASy - ENZYME nomenclature database: 1.6.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.7
            BRENDA, the Enzyme Database: 1.6.99.7
            SCOP (Structural Classification of Proteins): 1.6.99.7
///
ENTRY       EC 1.6.99.8
NAME        Aquacobalamin reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADH:cob(III)alamine oxidoreductase
REACTION    NADH + 2 Aquacob(III)alamin = NAD+ + 2 Cob(II)alamin
SUBSTRATE   NADH
            Aquacob(III)alamin
PRODUCT     NAD+
            Cob(II)alamin
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.8
            ExPASy - ENZYME nomenclature database: 1.6.99.8
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.8
            BRENDA, the Enzyme Database: 1.6.99.8
///
ENTRY       EC 1.6.99.9
NAME        Cob(II)alamin reductase
            Vitamin B12r reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADH:cob(II)alamin oxidoreductase
REACTION    NADH + 2 Cob(II)alamin = NAD+ + 2 Cob(I)alamin
SUBSTRATE   NADH
            Cob(II)alamin
PRODUCT     NAD+
            Cob(I)alamin
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.9
            ExPASy - ENZYME nomenclature database: 1.6.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.9
            BRENDA, the Enzyme Database: 1.6.99.9
///
ENTRY       EC 1.6.99.10
NAME        Deleted entry
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
COMMENT     Deleted entry. Now included with EC 1.6.99.7,
            Dihydropteridine reductase.
STRUCTURES  PDB: 1DHR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.10
            ExPASy - ENZYME nomenclature database: 1.6.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.10
            SCOP (Structural Classification of Proteins): 1.6.99.10
///
ENTRY       EC 1.6.99.11
NAME        Aquacobalamin reductase (NADPH)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADPH:aquacob(III)alamin oxidoreductase
REACTION    NADPH + 2 Aquacob(III)alamin = NADP+ + 2 Cob(II)alamin
SUBSTRATE   NADPH
            Aquacob(III)alamin
            Hydroxycobalamin
PRODUCT     NADP+
            Cob(II)alamin
COFACTOR    FAD
COMMENT     A flavoprotein.  Acts on aquacob(III)alamin and hydroxycobalamin,
            but not on cyanocobalamin.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.11
            ExPASy - ENZYME nomenclature database: 1.6.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.11
            BRENDA, the Enzyme Database: 1.6.99.11
///
ENTRY       EC 1.6.99.12
NAME        Cyanocobalamin reductase (NADPH, cyanide-eliminating)
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating)
REACTION    NADPH + Cyanocob(III)alamin = NADP+ + Cob(I)alamin +
            Hydrogen cyanide
SUBSTRATE   NADPH
            Cyanocob(III)alamin
PRODUCT     NADP+
            Cob(I)alamin
            Hydrogen cyanide
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.12
            ExPASy - ENZYME nomenclature database: 1.6.99.12
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.12
            BRENDA, the Enzyme Database: 1.6.99.12
///
ENTRY       EC 1.6.99.13
NAME        Ferric-chelate reductase
CLASS       Oxidoreductases
            Acting on NADH or NADPH
            With other acceptors
SYSNAME     NADH:Fe2+ oxidoreductase
REACTION    NADH + 2 Fe3+ = NAD+ + 2 Fe2+
SUBSTRATE   NADH
            Fe3+
PRODUCT     NAD+
            Fe2+
COMMENT     Involved in the transport of iron across plant plasma membranes.
DBLINKS     IUBMB Enzyme Nomenclature: 1.6.99.13
            ExPASy - ENZYME nomenclature database: 1.6.99.13
            WIT (What Is There) Metabolic Reconstruction: 1.6.99.13
            BRENDA, the Enzyme Database: 1.6.99.13
///
ENTRY       EC 1.7.2.1
NAME        Nitrite reductase (cytochrome)
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With a cytochrome as acceptor
SYSNAME     Nitric-oxide:ferricytochrome-c oxidoreductase
REACTION    Nitric oxide + H2O + 2 Ferricytochrome c =
            Nitrite + 2 Ferrocytochrome c;
            Nitric oxide + H2O + 2 Oxidized azurin = Nitrite + 
            2 Reduced azurin
SUBSTRATE   Nitric oxide
            H2O
            Ferricytochrome c
            Oxidized azurin
PRODUCT     Nitrite
            Ferrocytochrome c
            Reduced azurin
COFACTOR    Copper
COMMENT     A copper protein. Cytochrome c-552 or cytochrome c-553 from
            Pseudomonas denitrificans acts as acceptor.  There are two types
            of enzymes; blue and green enzymes.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.2.1
            ExPASy - ENZYME nomenclature database: 1.7.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.7.2.1
            BRENDA, the Enzyme Database: 1.7.2.1
///
ENTRY       EC 1.7.3.1
NAME        Nitroethane oxidase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With oxygen as acceptor
SYSNAME     Nitroethane:oxygen oxidoreductase
REACTION    Nitroethane + H2O + O2 = Acetaldehyde + Nitrite + H2O2
SUBSTRATE   Nitroethane
            H2O
            O2
PRODUCT     Acetaldehyde
            Nitrite
            H2O2
COMMENT     Acts on some other aliphatic nitro-compounds.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.3.1
            ExPASy - ENZYME nomenclature database: 1.7.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.7.3.1
            BRENDA, the Enzyme Database: 1.7.3.1
///
ENTRY       EC 1.7.3.2
NAME        Acetylindoxyl oxidase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With oxygen as acceptor
SYSNAME     N-Acetylindoxyl:oxygen oxidoreductase
REACTION    N-Acetylindoxyl + O2 = N-Acetylisatin
SUBSTRATE   N-Acetylindoxyl
            O2
PRODUCT     N-Acetylisatin
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.3.2
            ExPASy - ENZYME nomenclature database: 1.7.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.7.3.2
            BRENDA, the Enzyme Database: 1.7.3.2
///
ENTRY       EC 1.7.3.3
NAME        Urate oxidase
            Uricase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With oxygen as acceptor
SYSNAME     Urate:oxygen oxidoreductase
REACTION    Urate + O2 = Unidentified products
SUBSTRATE   Urate
            O2
PRODUCT     Unidentified products
COFACTOR    Copper
COMMENT     A copper protein. The initial products decompose to form
            allantoin.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       SME: SMb21284
            BSU: BG13986(pucL)
            SPO: SPCC1223.09(spcc1223.09)
            ATH: At2g26230(T1D16.13)
            DME: CG7171(Uro)
            MMU: 98907(Uox)
            HSA: 7377(UOX)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00366  [LV]-x-[LV]-[LIV]-K-[STV]-[ST]-x-[SN]-x-F-x(2)-[FY]-
                         x(4)-[FY]-x(2)-L-x(5)-R
STRUCTURES  PDB: 1UOX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.3.3
            ExPASy - ENZYME nomenclature database: 1.7.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.7.3.3
            BRENDA, the Enzyme Database: 1.7.3.3
            SCOP (Structural Classification of Proteins): 1.7.3.3
///
ENTRY       EC 1.7.3.4
NAME        Hydroxylamine oxidase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With oxygen as acceptor
SYSNAME     Hydroxylamine:oxygen oxidoreductase
REACTION    Hydroxylamine + O2 = Nitrite + H2O
SUBSTRATE   Hydroxylamine
            O2
PRODUCT     Nitrite
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein with seven c-type hemes and one P-460 type heme per
            subunit.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
STRUCTURES  PDB: 1FGJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.3.4
            ExPASy - ENZYME nomenclature database: 1.7.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.7.3.4
            BRENDA, the Enzyme Database: 1.7.3.4
            SCOP (Structural Classification of Proteins): 1.7.3.4
///
ENTRY       EC 1.7.3.5
NAME        3-aci-Nitropropanoate oxidase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With oxygen as acceptor
SYSNAME     3-aci-Nitropropanoate:oxygen oxidoreductase
REACTION    3-aci-Nitropropanoate + O2 = 3-Oxopropanoate + Nitrite + H2O2
SUBSTRATE   3-aci-Nitropropanoate
            O2
PRODUCT     3-Oxopropanoate
            Nitrite
            H2O2
COFACTOR    FMN
COMMENT     A flavoprotein (FMN).  The primary products of the enzymic
            reaction are probably the nitropropanoate free radical and
            superoxide.  Also acts, more slowly, on 4-aci-nitrobutanoate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.3.5
            ExPASy - ENZYME nomenclature database: 1.7.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.7.3.5
            BRENDA, the Enzyme Database: 1.7.3.5
///
ENTRY       EC 1.7.7.1
NAME        Ferredoxin--nitrite reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With an iron-sulfur protein as acceptor
SYSNAME     Ammonia:ferredoxin oxidoreductase
REACTION    NH3 + H2O + OH- + 3 Oxidized ferredoxin = Nitrite +
            3 Reduced ferredoxin
SUBSTRATE   NH3
            H2O
            OH-
            Oxidized ferredoxin
PRODUCT     Nitrite
            Reduced ferredoxin
COFACTOR    Iron
COMMENT     An iron protein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       PAE: PA4130
            CAC: CAC0094
            MTU: Rv2391(nirA)
            MTC: MT2461
            SYN: slr0898(nirA)
            DRA: DRA0013
            AFU: AF0164(nirA)
MOTIF       PS: PS00365  [STV]-G-C-x(3)-C-x(6)-[DE]-[LIVMF]-[GAT]-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.7.1
            ExPASy - ENZYME nomenclature database: 1.7.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.7.7.1
            BRENDA, the Enzyme Database: 1.7.7.1
///
ENTRY       EC 1.7.7.2
NAME        Ferredoxin--nitrate reductase
            Assimilatory nitrate reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With an iron-sulfur protein as acceptor
SYSNAME     Nitrite:ferredoxin oxidoreductase
REACTION    Nitrite + H2O + 2 Oxidized ferredoxin = Nitrate +
            2 Reduced ferredoxin
SUBSTRATE   Nitrite
            H2O
            Oxidized ferredoxin
PRODUCT     Nitrate
            Reduced ferredoxin
COFACTOR    Molybdenum
            Iron
            Sulfur
COMMENT     A molybdenum-iron-sulfur protein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
STRUCTURES  PDB: 1PFD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.7.2
            ExPASy - ENZYME nomenclature database: 1.7.7.2
            WIT (What Is There) Metabolic Reconstruction: 1.7.7.2
            BRENDA, the Enzyme Database: 1.7.7.2
            SCOP (Structural Classification of Proteins): 1.7.7.2
///
ENTRY       EC 1.7.99.1
NAME        Hydroxylamine reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     Ammonia:(acceptor) oxidoreductase
REACTION    NH3 + H2O + Acceptor = Hydroxylamine + Reduced acceptor
SUBSTRATE   NH3
            H2O
            Acceptor
PRODUCT     Hydroxylamine
            Reduced acceptor
            Reduced pyocyanine
            Methylene blue
            Flavin
COFACTOR    FAD
COMMENT     A flavoprotein.  Reduced pyocyanine, methylene blue and flavins
            act as donors for the reduction of hydroxylamine.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.1
            ExPASy - ENZYME nomenclature database: 1.7.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.1
            BRENDA, the Enzyme Database: 1.7.99.1
///
ENTRY       EC 1.7.99.2
NAME        Deleted entry
            Nitric-oxide reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
COMMENT     Deleted entry. Reaction may have been due to the combined action
            of EC 1.7.99.6 and 1.7.99.7.
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.2
            ExPASy - ENZYME nomenclature database: 1.7.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.2
///
ENTRY       EC 1.7.99.3
NAME        Nitrite reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     Nitric-oxide:(acceptor) oxidoreductase
REACTION    2 Nitric oxide + 2 H2O + Acceptor = 2 Nitrite + Reduced acceptor
SUBSTRATE   Nitric oxide
            H2O
            Acceptor
PRODUCT     Nitrite
            Reduced acceptor
            Pyocyanine
            Flavin
COFACTOR    Copper
            FAD
COMMENT     A copper protein; the Pseudomonas enzyme also contains FAD.
            Reduced pyocyanine, flavins, etc. act as donor for the reduction
            of nitrite. Formerly EC 1.6.6.5.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       SME: SMa1250(nirK)
STRUCTURES  PDB: 1AQ8  1AS6  1AS7  1AS8  1ET5  1ET7  1ET8  1HAU  1HAW  1J9Q  
                 1J9R  1J9S  1J9T  1NDR  1NDS  1NDT  1NIA  1NIB  1NIC  1NID  
                 1NIE  1NIF  1NTD  2AFN  2NRD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.3
            ExPASy - ENZYME nomenclature database: 1.7.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.3
            BRENDA, the Enzyme Database: 1.7.99.3
            SCOP (Structural Classification of Proteins): 1.7.99.3
///
ENTRY       EC 1.7.99.4
NAME        Nitrate reductase
            Respiratory nitrate reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     Nitrite:(acceptor) oxidoreductase
REACTION    Nitrite + Acceptor = Nitrate + Reduced acceptor;
            Nitrite + Ubiquinone = Nitrate + Ubiquinol
SUBSTRATE   Nitrite
            Acceptor
PRODUCT     Nitrate
            Reduced acceptor
            Benzyl viologen
COFACTOR    Cytochrome
            Molybdenum
            Iron
COMMENT     Contains molybdenum as a cofactor at active site.  Other subunits
            contain cytochrome c and iron-sulfur cluster.  Cytochrome c 
            subunit is transmembrane type,  Active subunit locates at 
            cytosol side.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b1224(narG) b1225(narH) b1226(narJ) b1227(narI) b1465(narV)
                 b1466(narW) b1467(narY) b1468(narZ) b2206(napA)
            ECE: Z2001(narG) Z2002(narH) Z2003(narJ) Z2004(narI) Z2244(narZ)
                 Z2245(narY) Z2246(narW) Z2247(narV) Z3463(napA)
            ECS: ECs1729 ECs1730 ECs1731 ECs1732 ECs2068 ECs2069 ECs2070
                 ECs2071 ECs3095
            YPE: YPO3038(napA)
            PMU: PM1594(napA)
            VCH: VCA0678
            PAE: PA1174(napA) PA1779 PA3872(narI) PA3873(narJ) PA3874(narH)
                 PA3875(narG)
            CJE: Cj0780(napA)
            MLO: mlr2864
            SME: SMb20986(narB)
            CCR: CC0617
            BSU: BG11081(narG) BG11082(narH) BG11083(narJ) BG11084(narI)
                 BG11095(nasC)
            BHA: BH0615(nasC)
            SAU: SA2182(narI) SA2183 SA2184(narH) SA2185(narG)
            SAV: SAV2378(narI) SAV2379(narJ) SAV2380(narH) SAV2381(narG)
            MTU: Rv0197 Rv1161(narG) Rv1162(narH) Rv1163(narJ) Rv1164(narI)
            MTC: MT0207 MT1198 MT1199 MT1200 MT1201
            SYN: sll1454(narB)
            AAE: aq_217(narB)
            MTH: MTH1567
            AFU: AF0501 AF0546(narI)
            APE: APE1288 APE1294 APE1300
MOTIF       PS: PS00490  [STA]-x-[STAC](2)-x(2)-[STA]-D-[LIVMY](2)-L-P-x-
                         [STAC](2)-x(2)-E
            PS: PS00551  [STAN]-x-[CH]-x(2,3)-C-[STAG]-[GSTVMF]-x-C-x-[LIVMFYW]-
                         x-[LIVMA]-x(3,4)-[DENQKHT]
            PS: PS00932  A-x(3)-[GDT]-I-x-[DNQTK]-x-[DEA]-x-[LIVM]-x-[LIVMC]-x-
                         [NS]-x(2)-[GS]-x(5)-A-x-[LIVM]-[ST]
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.4
            ExPASy - ENZYME nomenclature database: 1.7.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.4
            BRENDA, the Enzyme Database: 1.7.99.4
///
ENTRY       EC 1.7.99.5
NAME        5,10-Methylenetetrahydrofolate reductase (FADH2)
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     5-Methyltetrahyfrofolate:(acceptor) oxidoreductase
REACTION    5-Methyltetrahydrofolate + Acceptor =
            5,10-Methylenetetrahydrofolate + Reduced acceptor
SUBSTRATE   5-Methyltetrahydrofolate
            Acceptor
            FAD
PRODUCT     5,10-Methylenetetrahydrofolate
            Reduced acceptor
COMMENT     The acceptor is free FAD. Formerly EC 1.1.1.68 and 1.1.99.15
PATHWAY     PATH: MAP00670  One carbon pool by folate
            PATH: MAP00680  Methane metabolism
GENES       ECO: b3941(metF)
            ECE: Z5496(metF)
            ECS: ECs4870
            YPE: YPO0117(metF) YPO0287
            HIN: HI1444(metF)
            PMU: PM0235(metF)
            XFA: XF1121
            VCH: VC2685
            PAE: PA0430(metF)
            BUC: BU046(metF)
            NME: NMB0943
            NMA: NMA1139(metF)
            CJE: Cj1202(metF)
            MLO: mll1587
            SME: SMc01843(metF)
            CCR: CC2140
            LLA: L0099(metF)
            SPN: SP0586
            SPR: spr0515(metF)
            AAE: aq_1429(metF)
STRUCTURES  PDB: 1B5T  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.5
            ExPASy - ENZYME nomenclature database: 1.7.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.5
            BRENDA, the Enzyme Database: 1.7.99.5
            SCOP (Structural Classification of Proteins): 1.7.99.5
///
ENTRY       EC 1.7.99.6
NAME        Nitrous-oxide reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     Nitrogen:(acceptor) oxidoreductase (N2O-forming)
REACTION    Nitrogen + H2O + Acceptor = Nitrous oxide + Reduced acceptor
SUBSTRATE   Nitrogen
            H2O
            Acceptor
PRODUCT     Nitrous oxide
            Reduced acceptor
            Viologen
            Methylene blue
COFACTOR    Copper
COMMENT     A copper protein. Reduced viologens or methylene blue act as
            donors for the reduction of nitrous oxide.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       PAE: PA3392(nosZ)
            SME: SMa1182(nosZ)
MOTIF       PS: PS00078  V-x-H-x(33,40)-C-x(3)-C-x(3)-H-x(2)-M
STRUCTURES  PDB: 1FWX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.6
            ExPASy - ENZYME nomenclature database: 1.7.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.6
            BRENDA, the Enzyme Database: 1.7.99.6
///
ENTRY       EC 1.7.99.7
NAME        Nitric-oxide reductase
CLASS       Oxidoreductases
            Acting on other nitrogenous compounds as donors
            With other acceptors
SYSNAME     Nitrous-oxide:(acceptor) oxidoreductase (NO-forming)
REACTION    Nitrous oxide + H2O + Acceptor = 2 Nitric oxide + Reduced acceptor
SUBSTRATE   Nitrous oxide
            H2O
            Acceptor
            Phenazine methosulfate
PRODUCT     Nitric oxide
            Reduced acceptor
COMMENT     A heterodimer of cytochromes b and c.  Phenazine methosulfate can
            act as acceptor.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       PAE: PA0523(norC) PA0524(norB)
            NME: NMB1622
            NMA: NMA1886(nor)
            SME: SMa1269(norD) SMa1272(norQ) SMa1273(norB) SMa1276(norC)
                 SMa1279(norE)
MOTIF       PS: PS00077  [YWG]-[LIVFYWTA](2)-[VGS]-H-[LNP]-x-V-x(44,47)-H-H
            PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
STRUCTURES  PDB: 1EHE  1F24  1F25  1F26  
DBLINKS     IUBMB Enzyme Nomenclature: 1.7.99.7
            ExPASy - ENZYME nomenclature database: 1.7.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.7.99.7
            BRENDA, the Enzyme Database: 1.7.99.7
            SCOP (Structural Classification of Proteins): 1.7.99.7
///
ENTRY       EC 1.8.1.1
NAME        Deleted entry
            Cysteamine dehydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With NAD+ or NADP+ as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.1.1
            ExPASy - ENZYME nomenclature database: 1.8.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.1.1
///
ENTRY       EC 1.8.1.2
NAME        Sulfite reductase (NADPH)
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hydrogen-sulfide:NADP+ oxidoreductase
REACTION    Hydrogen sulfide + 3 NADP+ + 3 H2O = Sulfite + 3 NADPH
SUBSTRATE   Hydrogen sulfide
            NADP+
            H2O
PRODUCT     Sulfite
            NADPH
COFACTOR    Iron
            FAD
            FMN
COMMENT     An iron flavoprotein (FAD and FMN).
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b2763(cysI) b2764(cysJ)
            ECE: Z4073(cysI) Z4074(cysJ)
            ECS: ECs3618 ECs3619
            YPE: YPO3371(cysI) YPO3372(cysJ)
            XFA: XF1498 XF1499
            VCH: VC0384 VC0385
            PAE: PA1838(cysI) PA4513
            BUC: BU427(cysI) BU428(cysJ)
            NME: NMB1151 NMB1152 NMB1189 NMB1190
            NMA: NMA1362(cysI) NMA1363(cysJ)
            MLO: mll3230
            CCR: CC1119 CC3063
            BSU: BG14099(yvgQ) BG14100(yvgR)
            BHA: BH0609 BH0610
            SAU: SA2413
            SAV: SAV2604
            CTR: CT435
            CPN: CPn0548
            CPA: CP0204
            CPJ: cysJ
            SSO: SSO2909(cysI)
            SCE: YFR030W(MET10)
            SPO: SPCC584.01C(spcc584.01c)
MOTIF       PS: PS00365  [STV]-G-C-x(3)-C-x(6)-[DE]-[LIVMF]-[GAT]-[LIVMF]
STRUCTURES  PDB: 1AOP  1DDG  1DDI  2AOP  2GEP  3AOP  3GEO  4AOP  4GEP  5AOP  
                 5GEP  6GEP  7GEP  8GEP  
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.1.2
            ExPASy - ENZYME nomenclature database: 1.8.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.8.1.2
            BRENDA, the Enzyme Database: 1.8.1.2
            SCOP (Structural Classification of Proteins): 1.8.1.2
///
ENTRY       EC 1.8.1.3
NAME        Hypotaurine dehydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Hypotaurine:NAD+ oxidoreductase
REACTION    Hypotaurine + H2O + NAD+ = Taurine + NADH
SUBSTRATE   Hypotaurine
            H2O
            NAD+
PRODUCT     Taurine
            NADH
COFACTOR    Molybdenum
            Heme
COMMENT     A molybdohemoprotein.
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.1.3
            ExPASy - ENZYME nomenclature database: 1.8.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.8.1.3
            BRENDA, the Enzyme Database: 1.8.1.3
///
ENTRY       EC 1.8.1.4
NAME        Dihydrolipoamide dehydrogenase
            Diaphorase
            Lipoamide reductase (NADH)
            Lipoyl dehydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With NAD+ or NADP+ as acceptor
SYSNAME     Dihydrolipoamide:NAD+ oxidoreductase
REACTION    Dihydrolipoamide + NAD+ = Lipoamide + NADH
SUBSTRATE   Dihydrolipoamide
            Methylene blue
            NAD+
PRODUCT     Lipoamide
            NADH
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Component of the multienzyme pyruvate
            dehydrogenase complex and 2-oxoglutarate dehydrogenase complex.
            This enzyme was first shown to catalyse the oxidation of NADH by
            methylene blue; this activity was called diaphorase.
            Formerly EC 1.6.4.3.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0116(lpdA)
            ECE: Z0126(lpdA)
            ECS: ECs0120
            YPE: YPO3417(lpdA)
            HIN: HI1231(lpdA)
            PMU: PM0893(lpdA)
            XFA: XF0868 XF1548
            VCH: VC2412 VC2638
            PAE: PA1587(lpdG) PA2250(lpdV) PA4829(lpd3)
            BUC: BU207(lpdA)
            NME: NMB0947 NMB0957 NMB1344
            NMA: NMA1142(lpdA2) NMA1151(lpdA3) NMA1556(lpdA)
            RPR: RP460(pdhD) RP805(pdhD)
            RCO: RC0693(pdhD) RC1239(pdhD)
            MLO: mll4296 mll4470 mlr0388
            SME: SMc01035(lpdA1) SMc02487(lpdA2) SMc03204(lpdA3)
            CCR: CC0342 CC1731
            BSU: BG10210(pdhD) BG11725(lpd) BG12561(acoL)
            BHA: BH0216 BH0779 BH1825(acoL) BH2652(pdhD) BH2764
            SAU: SA0946(pdhD) SA1349
            SAV: SAV1080(pdhD) SAV1507
            LLA: L0036(pdhD)
            SPY: SPy1031(acoL)
            SPN: SP1161
            SPR: spr1048(acoL)
            MGE: MG271(pdhD)
            MPN: F11_orf457(pdhD)
            MPU: MYPU_0210(pdhD) MYPU_7610(pdhD)
            MTU: Rv0462 Rv0794c(lpdB) Rv3303c(lpdA)
            MTC: MT0478 MT0817 MT3402
            MLE: ML2387(lpd)
            CTR: CT557
            CMU: TC0846
            CPN: CPn0833
            CPA: CP1037
            CPJ: lpdA
            SYN: slr1096(phdD)
            DRA: DR2370 DR2526
            AAE: aq_736(lpdA)
            TMA: TM0381
            MJA: MJ0636
            MTH: MTH1648
            HAL: VNG2220G(lpdA)
            TAC: Ta0208 Ta1435
            TVO: TVG0102621 TVG1458424
            APE: APE1669
            SSO: SSO1123(pdhD-1) SSO1524(pdhD-2) SSO1565(pdhD-3)
                 SSO2559(pdhD-4)
            STO: ST0687
            SCE: YFL018C(LPD1) YPL017C(YPL017C)
            SPO: DLD1_1(dld1) DLD1_2(dld1)
            ATH: At1g48030(T2J15.6) At3g16950(K14A17.6) At3g17240(MGD8.7)
            CEL: LLC1.3
            DME: CG7430
            MMU: 107450(Dld)
            HSA: 1738(DLD)
DISEASE     MIM: 246900  Dihydrolipoamide dehydrogenase (E3 component of
                         pyruvate dehydrogenase
MOTIF       PS: PS00076  G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P
STRUCTURES  PDB: 1DXL  1EBD  1JEH  1LPF  1LVL  2PDD  2PDE  3LAD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.1.4
            ExPASy - ENZYME nomenclature database: 1.8.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.8.1.4
            BRENDA, the Enzyme Database: 1.8.1.4
            SCOP (Structural Classification of Proteins): 1.8.1.4
///
ENTRY       EC 1.8.2.1
NAME        Sulfite dehydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a cytochrome as acceptor
SYSNAME     Sulfite:ferricytochrome-c oxidoreductase
REACTION    Sulfite + 2 Ferricytochrome c + H2O = Sulfate +
            2 Ferrocytochrome c
SUBSTRATE   Sulfite
            Ferricytochrome c
            H2O
PRODUCT     Sulfate
            Ferrocytochrome c
COMMENT     Associated with cytochrome c-551.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.2.1
            ExPASy - ENZYME nomenclature database: 1.8.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.2.1
            BRENDA, the Enzyme Database: 1.8.2.1
///
ENTRY       EC 1.8.2.2
NAME        Thiosulfate dehydrogenase
            Tetrathionate synthase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a cytochrome as acceptor
SYSNAME     Thiosulfate:ferricytochrome-c oxidoreductase
REACTION    2 Thiosulfate + 2 Ferricytochrome c = Tetrathionate +
            2 Ferrocytochrome c
SUBSTRATE   Thiosulfate
            Ferricytochrome c
PRODUCT     Tetrathionate
            Ferrocytochrome c
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.2.2
            ExPASy - ENZYME nomenclature database: 1.8.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.8.2.2
            BRENDA, the Enzyme Database: 1.8.2.2
///
ENTRY       EC 1.8.2.3
NAME        Deleted entry
            Sulfide oxygenase (Cytochrome c-552.5)
            Sulfide dehydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a cytochrome as acceptor
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.2.3
            ExPASy - ENZYME nomenclature database: 1.8.2.3
            WIT (What Is There) Metabolic Reconstruction: 1.8.2.3
///
ENTRY       EC 1.8.3.1
NAME        Sulfite oxidase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a oxygen as acceptor
SYSNAME     Sulfite:oxygen oxidoreductase
REACTION    Sulfite + O2 + H2O = Sulfate + H2O2
SUBSTRATE   Sulfite
            O2
            H2O
PRODUCT     Sulfate
            H2O2
COFACTOR    Molybdenum
            Heme
COMMENT     A molybdohemoprotein.
PATHWAY     PATH: MAP00920  Sulfur metabolism
GENES       SME: SMc04049
            HSA: 6821(SUOX)
MOTIF       PS: PS00191  [FY]-[LIVMK]-x(2)-H-P-[GA]-G
            PS: PS00559  [GA]-x(3)-[KRNQHT]-x(11,14)-[LIVMFYWS]-x(8)-[LIVMF]-x-
                         C-x(2)-[DEN]-R-x(2)-[DE]
STRUCTURES  PDB: 1SOX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.3.1
            ExPASy - ENZYME nomenclature database: 1.8.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.3.1
            BRENDA, the Enzyme Database: 1.8.3.1
            SCOP (Structural Classification of Proteins): 1.8.3.1
///
ENTRY       EC 1.8.3.2
NAME        Thiol oxidase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a oxygen as acceptor
SYSNAME     Thiol:oxygen oxidoreductase
REACTION    4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O
SUBSTRATE   R'C(R)SH
            O2
PRODUCT     R'C(R)S-S(R)CR'
            H2O
COMMENT     R may be =S or =O, or a variety of other groups.  The enzyme is
            not specific for R'.
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.3.2
            ExPASy - ENZYME nomenclature database: 1.8.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.8.3.2
            BRENDA, the Enzyme Database: 1.8.3.2
///
ENTRY       EC 1.8.3.3
NAME        Glutathione oxidase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a oxygen as acceptor
SYSNAME     Glutathione:oxygen oxidoreductase
REACTION    2 Glutathione + O2 = Oxidized glutathione + H2O2
SUBSTRATE   Glutathione
            O2
PRODUCT     Oxidized glutathione
            H2O2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Also acts, more slowly, on L-cysteine and
            several other thiols.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.3.3
            ExPASy - ENZYME nomenclature database: 1.8.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.8.3.3
            BRENDA, the Enzyme Database: 1.8.3.3
///
ENTRY       EC 1.8.3.4
NAME        Methanethiol oxidase
            Methylmercaptan oxidase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a oxygen as acceptor
SYSNAME     Methanethiol:oxygen oxidoreductase
REACTION    Methanethiol + O2 + H2O = Formaldehyde + H2S + H2O2
SUBSTRATE   Methanethiol
            O2
            H2O
PRODUCT     Formaldehyde
            H2S
            H2O2
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.3.4
            ExPASy - ENZYME nomenclature database: 1.8.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.8.3.4
            UM-BBD (Biocatalysis/Biodegradation Database): 1.8.3.4
            BRENDA, the Enzyme Database: 1.8.3.4
///
ENTRY       EC 1.8.4.1
NAME        Glutathione--homocystine transhydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     Glutathione:homocystine oxidoreductase
REACTION    2 Glutathione + Homocystine = Oxidized glutathione +
            2 Homocysteine
SUBSTRATE   Glutathione
            Homocystine
PRODUCT     Oxidized glutathione
            Homocysteine
COMMENT     The reactions catalysed by this enzyme and by others in this
            subclass may be similar to those catalysed by EC 2.5.1.18.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.1
            ExPASy - ENZYME nomenclature database: 1.8.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.1
            BRENDA, the Enzyme Database: 1.8.4.1
///
ENTRY       EC 1.8.4.2
NAME        Protein-disulfide reductase (glutathione)
            Glutathione-insulin transhydrogenase
            Insulin reductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     Glutathione:protein-disulfide oxidoreductase
REACTION    2 Glutathione + Protein disulfide =
            Oxidized glutathione + Protein dithiol
SUBSTRATE   Glutathione
            Protein disulfide
            Insulin
PRODUCT     Oxidized glutathione
            Protein dithiol
            Insulin dithiol
COMMENT     Reduces insulin and some other proteins.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.2
            ExPASy - ENZYME nomenclature database: 1.8.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.2
            BRENDA, the Enzyme Database: 1.8.4.2
///
ENTRY       EC 1.8.4.3
NAME        Glutathione--CoA-glutathione transhydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     Coenzyme A:oxidized-glutathione oxidoreductase
REACTION    CoA + Oxidized glutathione = CoA-glutathione + Glutathione
SUBSTRATE   CoA
            Oxidized glutathione
PRODUCT     CoA-glutathione
            Glutathione
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.3
            ExPASy - ENZYME nomenclature database: 1.8.4.3
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.3
            BRENDA, the Enzyme Database: 1.8.4.3
///
ENTRY       EC 1.8.4.4
NAME        Glutathione--cystine transhydrogenase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     Glutathione:cystine oxidoreductase
REACTION    2 Glutathione + Cystine = Oxidized glutathione + 2 Cysteine
SUBSTRATE   Glutathione
            Cystine
PRODUCT     Oxidized glutathione
            Cysteine
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.4
            ExPASy - ENZYME nomenclature database: 1.8.4.4
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.4
            BRENDA, the Enzyme Database: 1.8.4.4
///
ENTRY       EC 1.8.4.5
NAME        Methionine-S-oxide reductase
            Methyl sulfoxide reductase I and II
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     L-Methionine:oxidized-thioredoxin S-oxidoreductase
REACTION    L-Methionine + Oxidized thioredoxin = L-Methionine S-oxide +
            Reduced thioredoxin
SUBSTRATE   L-Methionine
            Oxidized thioredoxin
PRODUCT     L-Methionine S-oxide
            Reduced thioredoxin
            Dithiothreitol
COMMENT     In the reverse reaction dithiothreitol can replace reduced
            thioredoxin, and other methyl sulfoxides can replace methionine
            sulfoxide.
PATHWAY     PATH: MAP00271  Methionine metabolism
GENES       MPU: MYPU_5060(pmsR) MYPU_7780(pmsR)
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.5
            ExPASy - ENZYME nomenclature database: 1.8.4.5
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.5
            BRENDA, the Enzyme Database: 1.8.4.5
///
ENTRY       EC 1.8.4.6
NAME        Protein-methionine-S-oxide reductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     Protein-L-methionine:oxidized-thioredoxin S-oxidoreductase
REACTION    Protein methionine + Oxidized thioredoxin =
            Protein L-methionine S-oxide + Reduced thioredoxin
SUBSTRATE   Protein methionine
            Oxidized thioredoxin
PRODUCT     Protein L-methionine S-oxide
            Reduced thioredoxin
            Dithiothreitol
COMMENT     Dithiothreitol, but not 2-mercaptoethanol, can replace a reduced
            thioredoxin in the reverse reaction. Does not act on free
            methionine (cf. EC 1.8.4.5).
GENES       ECO: b4219(msrA)
            ECE: Z5830(msrA)
            PMU: PM0605
            XFA: XF1940
            VCH: VC2549
            PAE: PA5018(msrA)
            NME: NMB0044
            NMA: NMA0290(pilB)
            HPY: HP0224(msrA)
            HPJ: jhp0210
            CJE: Cj0637c(mrsA)
            MLO: mll1760
            SME: SMc02885(msrA1)
            BSU: BG11627(msrA)
            BHA: BH1448 BH2249
            SAU: SA1194(msrA) SA1257
            SAV: SAV1412(msrA)
            LLA: L67708(pmsR)
            SPN: SP1359
            SPR: spr1217(msrA)
            CAC: CAC0088
            MGE: MG408
            MPN: C12_orf157(pmsR)
            UUR: UU289(msrA)
            MTU: Rv0137c
            MTC: MT0145
            MLE: ML2647
            TPA: TP0633
            SYN: sll1394(msrA) slr1795(msrA)
            DRA: DR1849
            MTH: MTH535
            HAL: VNG1180G(msrA)
            SSO: SSO1503(msr)
            SCE: YER042W(MXR1)
            ATH: At4g25130(F13M23.270)
            DME: CG7266(Eip71CD) CG7266_1(Eip71CD)
            MMU: 106916(Msra)
            HSA: 4482(MSRA)
STRUCTURES  PDB: 1FVA  1FVG  
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.6
            ExPASy - ENZYME nomenclature database: 1.8.4.6
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.6
            BRENDA, the Enzyme Database: 1.8.4.6
            SCOP (Structural Classification of Proteins): 1.8.4.6
///
ENTRY       EC 1.8.4.7
NAME        Enzyme-thiol transhydrogenase (oxidized-glutathione)
            Glutathione-dependent thiol:disulfide oxidoreductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a disulfide as acceptor
SYSNAME     [Xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase
REACTION    [Xanthine dehydrogenase] + Oxidized glutathione =
            [Xanthine oxidase] + Glutathione
SUBSTRATE   [Xanthine dehydrogenase]
            Oxidized glutathione
PRODUCT     [Xanthine oxidase]
            Glutathione
            Ricin
COMMENT     Converts EC 1.1.1.204 into EC 1.1.3.22 in the presence of
            oxidized glutathione; also reduces the disulfide bond of ricin.
            Not inhibited by Cu2+ or thiol reagents.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.4.7
            ExPASy - ENZYME nomenclature database: 1.8.4.7
            WIT (What Is There) Metabolic Reconstruction: 1.8.4.7
            BRENDA, the Enzyme Database: 1.8.4.7
///
ENTRY       EC 1.8.5.1
NAME        Glutathione dehydrogenase (ascorbate)
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With a quinone or similar compound as acceptor
SYSNAME     Glutathione:dehydroascorbate oxidoreductase
REACTION    2 Glutathione + Dehydroascorbate = Oxidized glutathione +
            Ascorbate
SUBSTRATE   Glutathione
            Dehydroascorbate
PRODUCT     Oxidized glutathione
            Ascorbate
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
            PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.5.1
            ExPASy - ENZYME nomenclature database: 1.8.5.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.5.1
            BRENDA, the Enzyme Database: 1.8.5.1
///
ENTRY       EC 1.8.6.1
NAME        Deleted entry
            Nitrate-ester reductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
COMMENT     Deleted entry. Now included with EC 2.5.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.6.1
            ExPASy - ENZYME nomenclature database: 1.8.6.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.6.1
///
ENTRY       EC 1.8.7.1
NAME        Sulfite reductase (ferredoxin)
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With an iron-sulfur protein as acceptor
SYSNAME     hydrogen-sulfide:ferredoxin oxidoreductase
REACTION    Hydrogen sulfide + 3 Oxidized ferredoxin + 3 H2O =
            Sulfite + 3 Reduced ferredoxin
SUBSTRATE   Hydrogen sulfide
            Oxidized ferredoxin
            H2O
PRODUCT     Sulfite
            Reduced ferredoxin
COFACTOR    Iron
COMMENT     An iron protein
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       SYN: slr0963(sir)
            MTH: MTH1819 MTH400
MOTIF       PS: PS00365  [STV]-G-C-x(3)-C-x(6)-[DE]-[LIVMF]-[GAT]-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.7.1
            ExPASy - ENZYME nomenclature database: 1.8.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.7.1
            BRENDA, the Enzyme Database: 1.8.7.1
///
ENTRY       EC 1.8.99.1
NAME        Sulfite reductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With other acceptors
SYSNAME     Hydrogen-sulfide:(acceptor) oxidoreductase
REACTION    Hydrogen sulfide + Acceptor + 3 H2O = Sulfite + Reduced acceptor
SUBSTRATE   Hydrogen sulfide
            Acceptor
            H2O
            Methyl viologen
PRODUCT     Sulfite
            Reduced acceptor
COFACTOR    Iron
COMMENT     An iron-protein. A stoichiometry of six molecules of reduced
            methyl viologen per molecule of sulfide formed was found.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.99.1
            ExPASy - ENZYME nomenclature database: 1.8.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.8.99.1
            BRENDA, the Enzyme Database: 1.8.99.1
///
ENTRY       EC 1.8.99.2
NAME        Adenylylsulfate reductase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With other acceptors
SYSNAME     AMP,sulfite:(acceptor) oxidoreductase
REACTION    AMP + Sulfite + Acceptor = Adenylylsulfate + Reduced acceptor
SUBSTRATE   AMP
            Sulfite
            Acceptor
            Methyl viologen
PRODUCT     Adenylylsulfate
            Reduced acceptor
COFACTOR    Iron
            FAD
COMMENT     An iron flavoprotein (FAD). Methyl viologen can act as acceptor.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       CAC: CAC0104
            AFU: AF1669(aprB) AF1670(aprA)
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.99.2
            ExPASy - ENZYME nomenclature database: 1.8.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.8.99.2
            BRENDA, the Enzyme Database: 1.8.99.2
///
ENTRY       EC 1.8.99.3
NAME        Hydrogensulfite reductase
            Bisulfite reductase
            Dissimilatory sulfite reductase
            Desulfoviridin
            Desulforubidin
            Desulfofuscidin
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With other acceptors
SYSNAME     Trithionate: (acceptor) oxidoreductase
REACTION    (O3S.S.SO3)2- + Acceptor + 2 H2O + HO- =
            3 (HSO3)- + Reduced acceptor
SUBSTRATE   (O3S.S.SO3)2-
            Acceptor
            H2O
            HO-
            Methyl viologen
PRODUCT     (HSO3)-
            Reduced acceptor
COFACTOR    Iron
            Sulfur
            Siroheme
COMMENT     Methyl viologen can act as acceptor. A group of sirohemoproteins
            containing iron-sulfur centres (P-582).
GENES       ECO: b0969(yccK)
            ECE: Z1321(yccK)
            ECS: ECs1053
            HIN: HI1371
            PMU: PM0401
            VCH: VC1356
            PAE: PA2608
            BUC: BU467(yccK)
            AFU: AF0423(dsrA) AF0424(dsrB) AF0425(dsrD) AF2228(dsvC)
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.99.3
            ExPASy - ENZYME nomenclature database: 1.8.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.8.99.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.8.99.3
            BRENDA, the Enzyme Database: 1.8.99.3
///
ENTRY       EC 1.8.99.4
NAME        Phosphoadenosine-phosphosulfate reductase
            PAPS reductase, thioredoxin-dependent
            PAdoPS reductase
            Thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase
            3'-Phosphoadenylylsulfate reductase
            Thioredoxin:3'-phospho-adenylylsulfate reductase
            PAPS sulfotransferase
CLASS       Oxidoreductases
            Acting on a sulfur group of donors
            With other acceptors
REACTION    3'-Phosphoadenosine 5'-phosphosulfate + Reduced thioredoxin =
            Phosphoadenosine phosphate + Oxidized thioredoxin + Sulfite
SUBSTRATE   3'-Phosphoadenosine 5'-phosphosulfate
            Reduced thioredoxin
PRODUCT     Phosphoadenosine phosphate
            Oxidized thioredoxin
            Sulfite
COMMENT     Specific for PAPS.
            The enzyme from E.coli will use thioredoxins from other species.
PATHWAY     PATH: MAP00920  Sulfur metabolism
GENES       ECO: b2762(cysH)
            ECE: Z4072(cysH)
            ECS: ECs3617
            YPE: YPO3370(cysH)
            XFA: XF1497
            VCH: VC0386
            PAE: PA1756(cysH)
            BUC: BU426(cysH)
            NME: NMB1155 NMB1193
            NMA: NMA1366(cysH)
            MLO: mll3228
            SME: SMa0851(nodH) SMc00092(cysH)
            CCR: CC1121
            BSU: BG11930(cysH) BG13107(yitB)
            BHA: BH1486(cysH)
            MTU: Rv2392(cysH)
            MTC: MT2462
            SYN: slr1791(cysH)
            DRA: DRA0015
            SSO: SSO2911(cysH)
            SCE: YPR167C(MET16)
            SPO: SPAC13G7.06(spac13g7.06)
STRUCTURES  PDB: 1SUR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.8.99.4
            ExPASy - ENZYME nomenclature database: 1.8.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.8.99.4
            SCOP (Structural Classification of Proteins): 1.8.99.4
///
ENTRY       EC 1.9.3.1
NAME        Cytochrome-c oxidase
            Cytochrome oxidase
            Cytochrome a3
            Cytochrome aa3
CLASS       Oxidoreductases
            Acting on heme group of donors
            With oxygen as acceptor
SYSNAME     Ferrocytochrome-c:oxygen oxidoreductase
REACTION    4 Ferrocytochrome c + O2 = 4 Ferricytochrome c + 2 H2O
SUBSTRATE   Ferrocytochrome c
            O2
PRODUCT     Ferricytochrome c
            H2O
COMMENT     A cytochrome of the a type containing copper.
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP03130  
GENES       VCH: VC1439 VC1440 VC1441 VC1442
            PAE: PA0105(coxB) PA0106(coxA) PA0108(coIII) PA0521 PA1552 PA1553
                 PA1554 PA1555 PA1556 PA1557 PA1856 PA4133
            NME: NMB1723 NMB1724 NMB1725
            NMA: NMA1977 NMA1978 NMA1979 NMA1980
            HPY: HP0144(fixN) HP0145(fixO) HP0146(CcoQ) HP0147(fixP)
            HPJ: jhp0132 jhp0133 jhp0134 jhp0135
            CJE: Cj1487c(ccoP) Cj1488c(ccoQ) Cj1489c(ccoO) Cj1490c(ccoN)
            RPR: RP191(coxC) RP405(coxA) RP406(coxB)
            RCO: RC0240(coxC) RC0469(ctaB) RC0553(coxA) RC0555(coxB)
            MLO: mll6628 mll6629 mll6630 mll9630 mll9631 mlr1039 mlr1041
                 mlr1042 mlr1043 mlr6411 mlr6412 mlr6414 mlr7490 mlr7491
                 mlr7496 msl6627 msr6413
            SME: SMa0612(fixN3) SMa0615(fixO3) SMa0616(fixQ3) SMa0617(fixP3)
                 SMa0765(fixN2) SMa0766(fixO2) SMa0767(fixQ2) SMa0769(fixP2)
                 SMa1213(fixP1) SMa1214(fixQ1) SMa1216(fixO1) SMa1220(fixN1)
                 SMb21368 SMb21370 SMc00009(ctaC) SMc00010(ctaD) SMc00013(ctaE)
                 SMc01982(coxM) SMc01983(coxN) SMc01984(coxO) SMc01985(coxP)
            ATU: AGR_C_2829 AGR_C_2832 AGR_C_2835
            CCR: CC1401 CC1402 CC1403 CC1404 CC3402 CC3406 CC3407
            BSU: BG10215(ctaC) BG10216(ctaD) BG10217(ctaE) BG10218(ctaF)
            BHA: BH0739 BH0740 BH2612(ctaF) BH2613(ctaE) BH2614(ctaD)
                 BH2615(ctaC)
            MTU: Rv2193(ctaE) Rv2200c(ctaC) Rv3043c(ctaD)
            MTC: MT2249 MT2256 MT3128
            MLE: ML0875(ctaC) ML0882(ctaE) ML1728
            SYN: sll0813(ctaC) slr1136(ctaC) slr1137(ctaD) slr1138(ctaE)
                 slr2082(ctaD) slr2083(ctaE)
            DRA: DR2620
            AAE: aq_2188(coxC) aq_2190(coxB) aq_2191(coxA1) aq_2191a(coxB2)
                 aq_2192(coxA2)
            AFU: AF0142 AF0144(cbaB) AF0190
            HAL: VNG0657G(coxA2) VNG0662G(coxC) VNG0665G(coxB1)
                 VNG2193G(coxA1) VNG2195G(coxB2)
            APE: APE0792 APE0793 APE1623 APE1720
            SCE: Q0045(COX1) Q0250(COX2) Q0275(COX3) YDL067C(COX9)
                 YGL187C(COX4) YGL191W(COX13) YHR051W(COX6) YIL111W(COX5B)
                 YLR038C(COX12) YLR395C(COX8) YMR256C(COX7) YNL052W(COX5A)
            SPO: COX1(cox1) COX2(cox2) COX3(cox3) COX4(cox4)
                 SPAC1B2.04(spac1b2.04) SPAC24C9.16C(spac24c9.16c)
                 SPCC1259.05C(spcc1259.05c) SPCC1442.08C(spcc1442.08c)
                 SPCC1739.09C(spcc1739.09c) SPCC338.10C(spcc338.10c)
            ATH: At1g22450(F12K8.20) At1g32710(F6N18.10) At1g80230(F18B13.29)
                 At3g15640(MSJ11.5) At4g28060(T13J8.170) At4g37830(T28I19.110)
            CEL: F26E4.6 F26E4.9 F54D8.2 Y37D8A.14
            DME: CG10396 CG10664 CG11015 CG11043 CG14028 CG14077 CG14235
                 CG14724(CoVa) CG17280 CG18193 CG2249 CG9603
            MMU: 102502(mt-Co3) 102503(mt-Co2) 102504(mt-Co1) 103099(Cox6a1)
                 103226(Cox7c) 104649(Cox6a2) 105958(Cox8b) 105959(Cox8a)
                 107460(Cox6b) 1316714(Cox7a1) 1316715(Cox7a3) 88473(Cox4)
                 88474(Cox5a)
            HSA: 1327(COX4) 1329(COX5B) 1333(COX5BL4) 1337(COX6A1)
                 1339(COX6A2) 1340(COX6B) 1345(COX6C) 1346(COX7A1) 1347(COX7A2)
                 1348(COX7A3) 1349(COX7B) 1350(COX7C) 1351(COX8) 4512(MTCO1)
                 4513(MTCO2) 4514(MTCO3) 9167(COX7A2L) 9377(COX5A)
DISEASE     MIM: 123864  Cytochrome c oxidase, subunit IV
            MIM: 123866  Cytochrome c oxidase, subunit Vb
            MIM: 123870  Cytochrome c oxidase, subunit VIII
            MIM: 123995  Cytochrome c oxidase, subunit VIIa, polypeptide-1,
                         muscle
            MIM: 123996  Cytochrome c oxidase, subunit VIIa, polypeptide-2,
                         liver
            MIM: 124089  Cytochrome c oxidase, subunit VIb
            MIM: 124090  Cytochrome c oxidase, subunit VIc
            MIM: 602072  Cytochrome c oxidase, subunit VIa, polypeptide-1
            MIM: 603774  Cytochrome C oxidase, subunit VII C
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00077  [YWG]-[LIVFYWTA](2)-[VGS]-H-[LNP]-x-V-x(44,47)-H-H
            PS: PS00078  V-x-H-x(33,40)-C-x(3)-C-x(3)-H-x(2)-M
            PS: PS00848  [LIVM](2)-[FYW]-x(10)-C-x(2)-C-G-x(2)-[FY]-K-L
            PS: PS01329  [LIV]-R-x-K-x-[FYW]-x-W-[GS]-D-G-x-[KH]-[ST]-x-F-x-N
STRUCTURES  PDB: 1AR1  1EHK  1HR8  1OCC  1OCO  1OCR  1OCZ  1QLE  2CUA  2OCC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.9.3.1
            ExPASy - ENZYME nomenclature database: 1.9.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.9.3.1
            BRENDA, the Enzyme Database: 1.9.3.1
            SCOP (Structural Classification of Proteins): 1.9.3.1
///
ENTRY       EC 1.9.3.2
NAME        Pseudomonas cytochrome oxidase
            Cytochrome cd
CLASS       Oxidoreductases
            Acting on heme group of donors
            With oxygen as acceptor
SYSNAME     Ferrocytochrome-c:oxygen oxidoreductase
REACTION    4 Ferrocytochrome c2 + O2 = 4 Ferricytochrome c2 + 2 H2O;
            2 Ferrocytochrome c2 + Nitrite = 2 Ferricytochrome c2 + H2O +
            Nitric oxide
SUBSTRATE   Ferrocytochrome c2
            O2
            Nitrite
            Hydroxylamine
PRODUCT     Ferricytochrome c2
            H2O
            Nitric oxide
            NH3
COMMENT     Hemeprotein contains cytochrome c and d. Nitrite and hydroxylamine 
            can act as acceptors.  
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       PAE: PA0519(nirS)
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
STRUCTURES  PDB: 1BL9  1DY7  1HZU  1HZV  1N15  1N50  1N90  1NIR  1NNO  
DBLINKS     IUBMB Enzyme Nomenclature: 1.9.3.2
            ExPASy - ENZYME nomenclature database: 1.9.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.9.3.2
            BRENDA, the Enzyme Database: 1.9.3.2
            SCOP (Structural Classification of Proteins): 1.9.3.2
///
ENTRY       EC 1.9.6.1
NAME        Nitrate reductase (cytochrome)
CLASS       Oxidoreductases
            Acting on heme group of donors
            With a nitrogenous group as acceptor
SYSNAME     Ferrocytochrome:nitrate oxidoreductase
REACTION    Ferrocytochrome + Nitrate = Ferricytochrome + Nitrite
SUBSTRATE   Ferrocytochrome
            Nitrate
PRODUCT     Ferricytochrome
            Nitrite
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.9.6.1
            ExPASy - ENZYME nomenclature database: 1.9.6.1
            WIT (What Is There) Metabolic Reconstruction: 1.9.6.1
            BRENDA, the Enzyme Database: 1.9.6.1
///
ENTRY       EC 1.9.99.1
NAME        Iron--cytochrome-c reductase
CLASS       Oxidoreductases
            Acting on heme group of donors
            With other acceptors
SYSNAME     Ferrocytochrome-c:Fe3+ oxidoreductase
REACTION    Ferrocytochrome c + Fe3+ Ferricytochrome c + Fe2+
SUBSTRATE   Ferrocytochrome c
            Fe3+
PRODUCT     Ferricytochrome c
            Fe2+
COFACTOR    Iron
COMMENT     An iron protein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.9.99.1
            ExPASy - ENZYME nomenclature database: 1.9.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.9.99.1
            BRENDA, the Enzyme Database: 1.9.99.1
///
ENTRY       EC 1.10.1.1
NAME        trans-Acenaphthene-1,2-diol dehydrogenase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With NAD+ or NADP+ as acceptor
SYSNAME     (+/-)-trans-Acenaphthene-1,2-diol:NADP+ oxidoreductase
REACTION    (+/-)-trans-Acenaphthene-1,2-diol + NADP+ = Acenaphthenequinone +
            NADPH
SUBSTRATE   (+/-)-trans-Acenaphthene-1,2-diol
            NADP+
PRODUCT     Acenaphthenequinone
            NADPH
COMMENT     Some preparations also utilize NAD+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.1.1
            ExPASy - ENZYME nomenclature database: 1.10.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.10.1.1
            BRENDA, the Enzyme Database: 1.10.1.1
///
ENTRY       EC 1.10.2.1
NAME        L-Ascorbate--cytochrome-b5 reductase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With a cytochrome as acceptor
SYSNAME     L-Ascorbate:ferricytochrome-b5 oxidoreductase
REACTION    L-Ascorbate + Ferricytochrome b5 = Monodehydroascorbate +
            Ferrocytochrome b5
SUBSTRATE   L-Ascorbate
            Ferricytochrome b5
PRODUCT     Monodehydroascorbate
            Ferrocytochrome b5
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.2.1
            ExPASy - ENZYME nomenclature database: 1.10.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.10.2.1
            BRENDA, the Enzyme Database: 1.10.2.1
///
ENTRY       EC 1.10.2.2
NAME        Ubiquinol--cytochrome-c reductase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With a cytochrome as acceptor
SYSNAME     Ubiquinol:ferricytochrome-c oxidoreductase
REACTION    QH2 + 2 Ferricytochrome c = Q + 2 Ferrocytochrome c
SUBSTRATE   QH2
            Ferricytochrome c
PRODUCT     Q
            Ferrocytochrome c
COFACTOR    Cytochrome b-562
            Cytochrome b-566
            Cytochrome c1
            2-Iron ferredoxin
COMMENT     Contains cytochromes b-562, b-566 and c1, and a 2-iron ferredoxin.
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP03140  
GENES       XFA: XF0908 XF0909 XF0910
            VCH: VC0573 VC0574 VC0575
            PAE: PA4429 PA4430 PA4431
            NME: NMB2051 NMB2052 NMB2053
            NMA: NMA0383(petA) NMA0384(petB) NMA0385(petC)
            HPY: HP1539(fbcH) HP1540(fbcF)
            HPJ: jhp1459 jhp1460 jhp1461
            CJE: Cj1184c(petC) Cj1185c(petB) Cj1186c(petA)
            RPR: RP270(petA) RP271(petB) RP272(fbcH)
            RCO: RC0358(petA) RC0359(petB) RC0360(fbcH)
            MLO: mll2705 mll2706 mll2707 mlr0970 mlr0971
            SME: SMc00187(fbcF) SMc00188(fbcB) SMc00189(fbcC)
            ATU: AGR_C_4072 AGR_C_4073 AGR_C_4074
            CCR: CC0472 CC0473 CC0474
            DRA: DR0435 DR0436
            AAE: aq_042(cyc) aq_044(petB) aq_045(petA)
            SCE: Q0105(CYTB) YBL045C(COR1) YDR529C(QCR7) YEL024W(RIP1)
                 YFR033C(QCR6) YGR183C(QCR9) YHR001W-A(QCR10) YJL166W(QCR8)
                 YOR065W(CYT1) YPR191W(QCR2)
            SPO: COB(cob) QCR8(qcr8) RIP1(rip1) SPBC16C6.08C(spbc16c6.08c)
                 SPBC29A3.18(spbc29a3.18) SPCC1682.01(spcc1682.01)
                 SPCC613.10(spcc613.10) SPCC737.02C(spcc737.02c)
            ATH: At1g15120(F9L1.5) At2g01090(F23H14.6) At3g27240(K17E12.6)
                 At3g52730(F3C22.130) At4g32470(F8B4.170) At5g13430(T22N19.80)
                 At5g13440(T22N19.90) At5g25450(F18G18.190) At5g40810(MHK7.4)
            CEL: C54G4.8 F42G8.12 F45H10.2 R07E4.3 T10B10.2 T24C4.1 T27E9.2
            DME: CG14508 CG17856 CG3560 CG4169 CG4769 CG7361 CG7361_1 CG7580
                 CG8764(Qcr9)
            HSA: 10975(UQCR) 1537(CYC1) 27089(QP-C) 4519(MTCYB) 7381(UQCRB)
                 7384(UQCRC1) 7385(UQCRC2) 7386(UQCRFS1) 7388(UQCRH)
DISEASE     MIM: 191327  Ubiquinol-cytochrome c reductase, Rieske iron-sulfur
                         polypeptide 1
            MIM: 191328  Ubiquinol-cytochrome c reductase core protein I
            MIM: 191329  Ubiquinol-cytochrome c reductase core protein II
            MIM: 191330  Ubinquinol-cytochrome c reductase ginding protein
MOTIF       PS: PS00143  G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-
                         [LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]
            PS: PS00199  C-[TK]-H-L-G-C-[LIVST]
            PS: PS00200  C-P-C-H-x-[GSA]
STRUCTURES  PDB: 1BCC  1BE3  1BGY  1EZV  1QCR  1RIE  2BCC  3BCC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.2.2
            ExPASy - ENZYME nomenclature database: 1.10.2.2
            WIT (What Is There) Metabolic Reconstruction: 1.10.2.2
            BRENDA, the Enzyme Database: 1.10.2.2
            SCOP (Structural Classification of Proteins): 1.10.2.2
///
ENTRY       EC 1.10.3.1
NAME        Catechol oxidase
            Diphenol oxidase
            o-Diphenolase
            Phenolase
            Polyphenol oxidase
            Tyrosinase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     1,2-Benzenediol:oxygen oxidoreductase
REACTION    2 Catechol + O2 = 2 1,2-Benzoquinone + 2 H2O
SUBSTRATE   Catechol
            O2
            L-Tyrosine
            L-Dopa
PRODUCT     1,2-Benzoquinone
            H2O
            L-Dopa
            Dopaquinone
COFACTOR    Copper
COMMENT     A group of copper proteins, that act also on a variety of
            substituted catechols, and many of which also catalyse the
            reaction listed under EC 1.14.18.1; this is especially true for
            the classical tyrosinase.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
MOTIF       PS: PS00497  H-x(4,5)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LVM]-x(3)-E
            PS: PS00498  D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D
STRUCTURES  PDB: 1BUG  1BT3  1BT2  1BT1  
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.1
            ExPASy - ENZYME nomenclature database: 1.10.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.1
            BRENDA, the Enzyme Database: 1.10.3.1
            SCOP (Structural Classification of Proteins): 1.10.3.1
///
ENTRY       EC 1.10.3.2
NAME        Laccase
            Urushiol oxidase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     Benzenediol:oxygen oxidoreductase
REACTION    4 Benzenediol + O2 = 4 Benzosemiquinone + 2 H2O
SUBSTRATE   Benzenediol
            O2
            E-Coniferyl alcohol
            Catechol
            p-Benzenediol
            Aminophenol
            Phenylenediamine
PRODUCT     Benzosemiquinone
            H2O
            (+)-Pinoresinol
COFACTOR    Copper
COMMENT     A group of multi-copper proteins of low specificity acting on both
            catechol and p-benzenediol, and often acting also on aminophenols
            and phenylenediamine. The semiquinone may react further either
            enzymically or non-enzymically.
            With peroxidase, this enzyme composes of the lignin and lignan 
            biosynthesis enzyme system in plants.  E-Coniferyl alcohol is 
            converted to (+)-pinoresinol with regio- and stereospecificity.  
            The reactions catalyzed by these enzymes proceed by bimolecular 
            phenoxy radical coupling.  Stereospecificity is retained by a 
            78-kilodalton dirigent protein which is lacking catalytic activity
            and involved in capture of E-coniferyl alcohol-derived free-radical
            intermediates.
MOTIF       PS: PS00079  G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x(8)-G-[LM]-x(3)-
                         [LIVMFYW]
            PS: PS00080  H-C-H-x(3)-H-x(3)-[AG]-[LM]
STRUCTURES  PDB: 1A65  
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.2
            ExPASy - ENZYME nomenclature database: 1.10.3.2
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.2
            BRENDA, the Enzyme Database: 1.10.3.2
            SCOP (Structural Classification of Proteins): 1.10.3.2
///
ENTRY       EC 1.10.3.3
NAME        L-Ascorbate oxidase
            Ascorbase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     L-Ascorbate:oxygen oxidoreductase
REACTION    2 L-Ascorbate + O2 = 2 Dehydroascorbate + 2 H2O
SUBSTRATE   L-Ascorbate
            O2
PRODUCT     Dehydroascorbate
            H2O
COFACTOR    Copper
COMMENT     A multicopper protein.
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
MOTIF       PS: PS00079  G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x(8)-G-[LM]-x(3)-
                         [LIVMFYW]
            PS: PS00080  H-C-H-x(3)-H-x(3)-[AG]-[LM]
STRUCTURES  PDB: 1AOZ  1ASO  1ASP  1ASQ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.3
            ExPASy - ENZYME nomenclature database: 1.10.3.3
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.3
            BRENDA, the Enzyme Database: 1.10.3.3
            SCOP (Structural Classification of Proteins): 1.10.3.3
///
ENTRY       EC 1.10.3.4
NAME        o-Aminophenol oxidase
            Isophenoxazine synthase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     2-Aminophenol:oxygen oxidoreductase
REACTION    2 2-Aminophenol + 3 O2 = 2 Isophenoxazine + 6 H2O
SUBSTRATE   2-Aminophenol
            O2
PRODUCT     Isophenoxazine
            H2O
COFACTOR    FAD
            Manganese
COMMENT     A flavoprotein, requiring Mn2+.  Isophenoxazine may be formed by
            a secondary condensation from the initial oxidation product.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.4
            ExPASy - ENZYME nomenclature database: 1.10.3.4
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.4
            BRENDA, the Enzyme Database: 1.10.3.4
///
ENTRY       EC 1.10.3.5
NAME        3-Hydroxyanthranilate oxidase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     3-Hydroxyanthranilate:oxygen oxidoreductase
REACTION    3-Hydroxyanthranilate + O2 =
            6-Imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
SUBSTRATE   3-Hydroxyanthranilate
            O2
PRODUCT     6-Imino-5-oxocyclohexa-1,3-dienecarboxylate
            H2O2
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.5
            ExPASy - ENZYME nomenclature database: 1.10.3.5
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.5
            BRENDA, the Enzyme Database: 1.10.3.5
///
ENTRY       EC 1.10.3.6
NAME        Rifamycin-B-oxidase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     Rifamycin-B:oxygen oxidoreductase
REACTION    Rifamycin B + O2 = Rifamycin O + H2O2
SUBSTRATE   Rifamycin B
            O2
            Benzene-1,4-diol
PRODUCT     Rifamycin O
            H2O2
COMMENT     Acts also on benzene-1,4-diol and, more slowly, on some other
            p-quinols.  Not identical with EC 1.10.3.1, 1.10.3.2, 1.10.3.4 or
            1.10.3.5.
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.6
            ExPASy - ENZYME nomenclature database: 1.10.3.6
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.6
            BRENDA, the Enzyme Database: 1.10.3.6
///
ENTRY       EC 1.10.3.7
NAME        Sulochrin oxidase ((+)-bisdechlorogeodin-forming)
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     Sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)
REACTION    2 Sulochrin + O2 = 2 (+)-Bisdechlorogeodin + 2 H2O
SUBSTRATE   Sulochrin
            O2
PRODUCT     (+)-Bisdechlorogeodin
            H2O
COMMENT     Also acts on several diphenols and phenylenediamines, but has low
            affinity for these substrates.  Involved in the biosynthesis of
            mould metabolites related to the antibiotic griseofulvin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.7
            ExPASy - ENZYME nomenclature database: 1.10.3.7
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.7
            BRENDA, the Enzyme Database: 1.10.3.7
///
ENTRY       EC 1.10.3.8
NAME        Sulochrin oxidase ((-)-bisdechlorogeodin-forming)
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With oxygen as acceptor
SYSNAME     Sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)
REACTION    2 Sulochrin + O2 = 2 (-)-Bisdechlorogeodin + 2 H2O
SUBSTRATE   Sulochrin
            O2
PRODUCT     (-)-Bisdechlorogeodin
            H2O
COMMENT     Also acts on several diphenols and phenylenediamines, but has low
            affinity for these substrates.  Involved in the biosynthesis of
            mould metabolites related to the antibiotic griseofulvin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.3.8
            ExPASy - ENZYME nomenclature database: 1.10.3.8
            WIT (What Is There) Metabolic Reconstruction: 1.10.3.8
            BRENDA, the Enzyme Database: 1.10.3.8
///
ENTRY       EC 1.10.99.1
NAME        Plastoquinol--plastocyanin reductase
CLASS       Oxidoreductases
            Acting on diphenols and related substances as donors
            With other acceptors
SYSNAME     Plastoquinol:oxidized-plastocyanin oxidoreductase
REACTION    Plastoquinol-1 + 2 Oxidized plastocyanin =
            Plastoquinone + 2 Reduced plastocyanin
SUBSTRATE   Plastoquinol-1
            Oxidized plastocyanin
            Plastoquinal-9
            Ubiquinol
            Cytochrome c-552
PRODUCT     Plastoquinone
            Reduced plastocyanin
            Ubiquinone
COMMENT     A cytochrome f,b6 complex separated from chloroplasts.
            Also acts, more slowly, on plastoquinol-9 and ubiquinols.
            Cytochrome c-552 can act instead of plastocyanin, more
            slowly.
PATHWAY     PATH: MAP00195  Photosynthesis
GENES       SYN: sll1182(petC) sll1316(petC) slr1185(petC)
MOTIF       PS: PS00199  C-[TK]-H-L-G-C-[LIVST]
            PS: PS00200  C-P-C-H-x-[GSA]
STRUCTURES  PDB: 2B3I  1B3I  
DBLINKS     IUBMB Enzyme Nomenclature: 1.10.99.1
            ExPASy - ENZYME nomenclature database: 1.10.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.10.99.1
            BRENDA, the Enzyme Database: 1.10.99.1
            SCOP (Structural Classification of Proteins): 1.10.99.1
///
ENTRY       EC 1.11.1.1
NAME        NADH peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     NADH:hydrogen-peroxide oxidoreductase
REACTION    NADH + H2O2 = NAD+ + 2 H2O
SUBSTRATE   NADH
            H2O2
            Ferricyanide
            Quinone
PRODUCT     NAD+
            H2O
            Ferrocyanide
            Hydroquinone
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Ferricyanide, quinones, etc., can replace
            H2O2.
STRUCTURES  PDB: 2NPX  1NHS  1NHR  1NHQ  1NHP  1JOA  1F8W  1NPX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.1
            ExPASy - ENZYME nomenclature database: 1.11.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.1
            BRENDA, the Enzyme Database: 1.11.1.1
            SCOP (Structural Classification of Proteins): 1.11.1.1
///
ENTRY       EC 1.11.1.2
NAME        NADPH peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     NADPH:hydrogen-peroxide oxidoreductase
REACTION    NADPH + H2O2 = NADP+ + 2 H2O
SUBSTRATE   NADPH
            H2O2
PRODUCT     NADP+
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.2
            ExPASy - ENZYME nomenclature database: 1.11.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.2
            BRENDA, the Enzyme Database: 1.11.1.2
///
ENTRY       EC 1.11.1.3
NAME        Fatty acid peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Hexadecanoate:hydrogen-peroxide oxidoreductase
REACTION    Palmitate + 2 H2O2 = Pentadecanal + CO2 + 3 H2O
SUBSTRATE   Palmitate
            H2O2
PRODUCT     Pentadecanal
            CO2
            H2O
COMMENT     Acts on long-chain fatty acids from dodecanoic to octadecanoic
            acid.
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.3
            ExPASy - ENZYME nomenclature database: 1.11.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.3
            BRENDA, the Enzyme Database: 1.11.1.3
///
ENTRY       EC 1.11.1.4
NAME        Transferred to EC 1.13.11.11
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
COMMENT     Transferred entry. Now EC 1.13.11.11 - Tryptophan 2,3-dioxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.4
            ExPASy - ENZYME nomenclature database: 1.11.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.4
///
ENTRY       EC 1.11.1.5
NAME        Cytochrome-c peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Ferrocytochrome-c:hydrogen-peroxide oxidoreductase
REACTION    2 Ferrocytochrome c + H2O2 = 2 Ferricytochrome c + 2 H2O
SUBSTRATE   Ferrocytochrome c
            H2O2
PRODUCT     Ferricytochrome c
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein.
GENES       ECO: b3518(yhjA)
            ECE: Z4931(yhjA)
            YPE: YPO3342(yhjA)
            PMU: PM0939
            VCH: VC0089
            PAE: PA4587(ccpR)
            HPY: HP1461
            HPJ: jhp1354
            CJE: Cj0020c Cj0358
            MLO: mlr5805
            AAE: aq_136(cpx)
            SCE: YKR066C(CCP1)
MOTIF       PS: PS00190  C-{CPWHF}-{CPWR}-C-H-{CFYW}
            PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
STRUCTURES  PDB: 1CMU  1CMT  1CMQ  1CMP  1CCP  1CCL  1CCK  1DJ5  1DS4  1DSE  
                 1DSG  1DSO  1DSP  1EB7  1EBE  1RYC  2CCP  2CEP  2CYP  1CPD  
                 3CCP  1CCI  1CCG  1CCE  1CCC  1CCB  1CCA  1BVA  1BJ9  1BES  
                 1BEQ  3CCX  1BEP  1BEM  1BEK  4CCP  4CCX  5CCP  6CCP  7CCP  
                 1CPE  1CPF  1CPG  1CYF  1DCC  1DJ1  1CCJ  1JDR  1BEJ  1AA4  
                 1AC4  1AC8  1AEB  1AED  1AEE  1AEF  1AEG  1AEH  1AEJ  1AEK  
                 1AEM  1AEN  1AEO  1AEQ  1A2G  1A2F  1AEV  1AEU  1AET  1AES  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.5
            ExPASy - ENZYME nomenclature database: 1.11.1.5
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.5
            BRENDA, the Enzyme Database: 1.11.1.5
            SCOP (Structural Classification of Proteins): 1.11.1.5
///
ENTRY       EC 1.11.1.6
NAME        Catalase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Hydorogen-peroxide:hydrogen-peroxide oxidoreductase
REACTION    2 H2O2 = O2 + 2 H2O
SUBSTRATE   H2O2
            Ethanol
PRODUCT     O2
            H2O
COFACTOR    Heme
            Manganese
COMMENT     A hemoprotein. Several organic substances, especially ethanol,
            can act as hydrogen donor. A manganese protein containing Mn(III)
            in the resting state, which also belongs here, is often called
            pseudocatalase.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00680  Methane metabolism
GENES       ECO: b1732(katE) b3942(katG)
            ECE: Z2761(katE) Z5497(katG)
            ECS: ECs2438 ECs4871
            YPE: YPO1207(katA) YPO3319(katY)
            HIN: HI0928(hktE)
            PMU: PM0032(hktE)
            XFA: XF2232
            VCH: VC1560 VC1585
            PAE: PA2147(katE) PA4236(katA) PA4613(katB)
            NME: NMB0216
            NMA: NMA0050(katA)
            HPY: HP0875(kata)
            HPJ: jhp0809
            CJE: Cj1385(katA)
            MLO: mlr2101 mlr6940
            SME: SMa2379 SMb20007(catC) SMc00819(katA)
            CCR: CC3043
            BSU: BG10849(katA) BG11102(katB) BG11945(katX)
            BHA: BH0906 BH1306(katX) BH1980(katB)
            SAU: SA1170(katA)
            SAV: SAV1319(katA)
            MTU: Rv1908c(katG)
            MTC: MT1959
            SYN: sll1987(katG)
            DRA: DR1998 DRA0259
            AFU: AF2233(perA)
            HAL: VNG6294G(perA)
            SCE: YDR256C(CTA1) YGR088W(CTT1)
            SPO: CTA1(cta1)
            ATH: At4g35090(M4E13.140)
            DME: CG6871(Cat) CG9314
            MMU: 88271(Cas1)
            HSA: 847(CAT)
DISEASE     MIM: 115500  Catalase
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
            PS: PS00437  R-[LIVMFSTAN]-F-[GASTNP]-Y-x-D-[AST]-[QEH]
            PS: PS00438  [IF]-x-[RH]-x(4)-[EQ]-R-x(2)-H-x(2)-[GAS]-[GASTFY]-
                         [GAST]
STRUCTURES  PDB: 1GGK  1HBZ  1IPH  1QF7  1QQW  2CAE  1GGJ  1GGH  1GGF  2CAF  
                 1GGE  1GG9  1F4J  1E93  1DGH  1DGG  1DGF  1DGB  1CF9  1A4E  
                 7CAT  2CAG  4CAT  2CAH  4BLC  8CAT  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.6
            ExPASy - ENZYME nomenclature database: 1.11.1.6
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.6
            BRENDA, the Enzyme Database: 1.11.1.6
            SCOP (Structural Classification of Proteins): 1.11.1.6
///
ENTRY       EC 1.11.1.7
NAME        Peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Donor:hydrogen-peroxide oxidoreductase
REACTION    Donor + H2O2 = Oxidized donor + 2 H2O
SUBSTRATE   Donor
            H2O2
PRODUCT     Oxidized donor
            H2O
COFACTOR    Heme
COMMENT     A hemeprotein.  In plants, this enzyme with laccase 
            (cf. EC 1.10.3.2) is a component of the lignin and lignan 
            biosynthesis enzyme system.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00680  Methane metabolism
            PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       ATH: At2g38380(T19C21.13) At3g49110(T2J13.50)
            CEL: F09F3.5
            DME: CG10209 CG11765 CG12405 CG3477(Pxd)
            MMU: 894320(Aop2) 97137(Mpo)
            HSA: 4025(LPO) 4353(MPO) 8288(EPX) 9588(KIAA0106)
DISEASE     MIM: 254600  Myeloperoxidase
MOTIF       PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
STRUCTURES  PDB: 1ARU  3ATJ  1ARP  7ATJ  6ATJ  1SCH  1QO4  1QJR  1PA2  1MYP  
                 1MNP  1MHL  1HSR  1GZB  1GZA  1FHF  1D2V  1CXP  1CK6  1C8I  
                 1BQW  1BGP  1ATJ  1ARY  1ARX  1ARW  1ARV  2ATJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.7
            ExPASy - ENZYME nomenclature database: 1.11.1.7
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.7
            BRENDA, the Enzyme Database: 1.11.1.7
            SCOP (Structural Classification of Proteins): 1.11.1.7
///
ENTRY       EC 1.11.1.8
NAME        Iodide peroxidase
            Iodotyrosine deiodase
            Iodinase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Iodide:hydrogen-peroxide oxidoreductase
REACTION    Iodide + H2O2 = Iodine + 2 H2O
SUBSTRATE   Iodide
            H2O2
PRODUCT     Iodine
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       HSA: 7173(TPO)
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.8
            ExPASy - ENZYME nomenclature database: 1.11.1.8
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.8
            BRENDA, the Enzyme Database: 1.11.1.8
///
ENTRY       EC 1.11.1.9
NAME        Glutathione peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Glutathione:hydrogen-peroxide oxidoreductase
REACTION    2 Glutathione + H2O2 = Oxidized glutathione + 2 H2O
SUBSTRATE   Glutathione
            H2O2
            Steroid hydroperoxide
            Lipid hydroperoxide
PRODUCT     Oxidized glutathione
            H2O
COFACTOR    Selenium
COMMENT     A protein containing a selenocysteine residue. Steroid and lipid
            hydroperoxides, but not the product of reaction of EC 1.13.11.12
            on phospholipids, can act as acceptor, but more slowly than H2O2.
            (cf. EC 1.11.1.12)
            #STRUCTURE:
            Residue 45 is selenocysteine in rat and bovine enzymes. This
            residue is coded by a stop codon, TGA (Chambers et al. EMBO J.,
            5, 1221-1227, 1986) and is derived from serine pretranscriptional.
            (Sunde and Everson, J. Biol. Chem., 262, 933-937, 1987).
PATHWAY     PATH: MAP00480  Glutathione metabolism
GENES       XFA: XF1890
            PAE: PA0838 PA1287 PA2826
            NME: NMB1621
            NMA: NMA1820(gpxA)
            CCR: CC1730
            BSU: BG11530(bsaA)
            BHA: BH2830(bsaA)
            SAU: SA1146(bsaA) SA2414
            SAV: SAV1292(bsaA) SAV2605
            LLA: L0198(gpo)
            SPY: SPy0605(bsaA)
            SPN: SP0313
            SPR: spr0285(basA)
            CAC: CAC1549(bsaA) CAC1570(bsaA) CAC1571
            SYN: slr1171(gpx1) slr1992(gpx2)
            SCE: YBR244W(GPX2) YIR037W(HYR1) YKL026C(GPX1)
            SPO: GPX1(gpx1)
            ATH: At2g25080(F13D4.40)
            CEL: C11E4.1 C11E4.2 F26E4.12 R03G5.5 R05H10.5 T09A12.2
            DME: CG12013 CG15116
            MMU: 104886(Gpx5) 104887(Gpx1) 105102(Gpx3)
            HSA: 2876(GPX1) 2877(GPX2) 2878(GPX3) 2879(GPX4) 2880(GPX5)
                 2881(GPX6)
DISEASE     MIM: 138319  Glutathione peroxidase-2, gastrointestinal
            MIM: 138320  Glutathione peroxidase-1
            MIM: 138321  Glutathione peroxidase-3, plasma
            MIM: 138322  Glutathione peroxidase-4 (phospholipid
                         hydroperoxidase)
MOTIF       PS: PS00460  [GN]-[RKHNFYC]-x-[LIVMFC]-[LIVMF](2)-x-N-[VT]-x-[STC]-
                         x-C-[GA]-x-T
            PS: PS00763  [LIV]-[AGD]-F-P-[CS]-[NG]-Q-F
STRUCTURES  PDB: 1GP1  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.9
            ExPASy - ENZYME nomenclature database: 1.11.1.9
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.9
            BRENDA, the Enzyme Database: 1.11.1.9
            SCOP (Structural Classification of Proteins): 1.11.1.9
///
ENTRY       EC 1.11.1.10
NAME        Chloride peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Chloride:hydrogen-peroxide oxidoreductase
REACTION    2 RH + 2 Cl- + H2O2 = 2 RCl + 2 H2O
SUBSTRATE   RH
            Cl-
            Br-
            I-
            H2O2
PRODUCT     RCl
            RBr
            RI
            H2O
COFACTOR    Heme
COMMENT     Brings about the chlorination of a range of organic molecules,
            forming stable C-Cl bonds. Can also act on Br- and I-. Probably
            a heme-thiolate protein (P-450).
GENES       MLO: mlr0978
            SME: SMa1809
            SYN: slr0314
STRUCTURES  PDB: 1QI9  1A7U  1A88  1A8Q  1A8S  1A8U  1BRT  1CPO  1IDQ  1IDU  
                 1QHB  1VNC  1VNE  1VNF  1VNG  1VNH  1VNI  1VNS  2CPO  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.10
            ExPASy - ENZYME nomenclature database: 1.11.1.10
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.10
            BRENDA, the Enzyme Database: 1.11.1.10
            SCOP (Structural Classification of Proteins): 1.11.1.10
///
ENTRY       EC 1.11.1.11
NAME        L-Ascorbate peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     L-Ascorbate:hydrogen-peroxide oxidoreductase
REACTION    L-Ascorbate + H2O2 = Dehydroascorbate + 2 H2O
SUBSTRATE   L-Ascorbate
            H2O2
PRODUCT     Dehydroascorbate
            H2O
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
GENES       ATH: At1g07890(F24B9.2) At3g09640(F11F8.23) At4g09010(F23J3.40)
                 At4g35000(M4E13.60) At4g35970(T19K4.100)
MOTIF       PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
STRUCTURES  PDB: 1APX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.11
            ExPASy - ENZYME nomenclature database: 1.11.1.11
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.11
            BRENDA, the Enzyme Database: 1.11.1.11
            SCOP (Structural Classification of Proteins): 1.11.1.11
///
ENTRY       EC 1.11.1.12
NAME        Phospholipid-hydroperoxide glutathione peroxidase
            Peroxidation-inhibiting protein
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Glutathione:lipid-hydroperoxide oxidoreductase
REACTION    2 Glutathione + a Lipid hydroperoxide = Oxidized glutathione +
            Lipid + 2 H2O
SUBSTRATE   Glutathione
            Lipid hydroperoxide
PRODUCT     Oxidized glutathione
            Lipid
            H2O
COMMENT     A protein containing a selenocysteine residue.  The products of
            action of EC 1.13.11.12 on phospholipids can act as acceptor;
            H2O2 can also act, but much more slowly (cf. EC 1.11.19).
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.12
            ExPASy - ENZYME nomenclature database: 1.11.1.12
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.12
            BRENDA, the Enzyme Database: 1.11.1.12
///
ENTRY       EC 1.11.1.13
NAME        Manganese peroxidase
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Mn(II):hydrogen-peroxide oxidoreductase
REACTION    2 Mn(II) + 2 H+ + H2O2 = 2 Mn(III) + 2 H2O
SUBSTRATE   Mn(II)
            H+
            H2O2
PRODUCT     Mn(III)
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein.  Involved in the oxidative degradation of lignin
            in white rot besidiomycetes.
MOTIF       PS: PS00435  [DET]-[LIVMTA]-x(2)-[LIVM]-[LIVMSTAG]-[SAG]-[LIVMSTAG]-
                         H-[STA]-[LIVMFY]
            PS: PS00436  [SGATV]-x(3)-[LIVMA]-R-[LIVMA]-x-[FW]-H-x-[SAC]
STRUCTURES  PDB: 1MN2  1BQW  1MN1  1QJR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.13
            ExPASy - ENZYME nomenclature database: 1.11.1.13
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.13
            BRENDA, the Enzyme Database: 1.11.1.13
            SCOP (Structural Classification of Proteins): 1.11.1.13
///
ENTRY       EC 1.11.1.14
NAME        Diarylpropane peroxidase
            Diarylpropane oxygenase
            Ligninase I
CLASS       Oxidoreductases
            Acting on a peroxide as acceptor
SYSNAME     Diarylpropane:oxygen,hydrogen-peroxide oxidoreductase
            $ (C-C-bond-cleaving)
REACTION    1,2-Bis(3,4-dimethoxyphenyl)propane-1,3-diol + H2O2 =
            Veratraldehyde + 1-(3,4-Dimethylphenyl)ethane-1,2-diol + 4 H2O
SUBSTRATE   1,2-Bis(3,4-dimethoxyphenyl)propane-1,3-diol
            H2O2
PRODUCT     Veratraldehyde
            1-(3,4-Dimethylphenyl)ethane-1,2-diol
            H2O
COFACTOR    Heme
COMMENT     A hemoprotein. Brings about the oxidative cleavate of C-C bonds
            in a number of model compounds, and oxidizes benzyl alcohols to
            aldehydes or ketones. Involved in the oxidative breakdown of
            lignin in white rot basidiomycetes.
STRUCTURES  PDB: 1B80  1B85  1BQW  1B82  1QJR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.11.1.14
            ExPASy - ENZYME nomenclature database: 1.11.1.14
            WIT (What Is There) Metabolic Reconstruction: 1.11.1.14
            BRENDA, the Enzyme Database: 1.11.1.14
            SCOP (Structural Classification of Proteins): 1.11.1.14
///
ENTRY       EC 1.12.1.1
NAME        Transferred to EC 1.18.99.1
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With NAD+ or NADP+ as acceptor
COMMENT     Transferred entry. Now EC 1.18.99.1 - Hydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.1.1
            ExPASy - ENZYME nomenclature database: 1.12.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.12.1.1
///
ENTRY       EC 1.12.1.2
NAME        Hydrogen dehydrogenase
            Hydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     hydrogen:NAD+ oxidoreductase
REACTION    H2 + NAD+ = H+ + NADH
SUBSTRATE   H2
            NAD+
PRODUCT     H+
            NADH
COFACTOR    Iron
            Nickel
            Flavin
COMMENT     Contains iron, nickel and flavin.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00507  R-G-[LIVMF]-E-x(15)-[QESM]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2,3)-H
            PS: PS00641  P-x(2)-C-[YWSD]-x(7)-G-x-C-R-x-C
            PS: PS00642  C-P-x-C-[DE]-x-[GS](2)-x-C-x-L-Q
            PS: PS00643  R-C-[LIVM]-x-C-x-R-C-[LIVMT]-x-[LMFY]
            PS: PS00644  G-[AM]-G-[AR]-Y-[LIVM]-C-G-[DE](2)-[STA](2)-[LIM](2)-
                         [END]-S
            PS: PS00645  E-[ST]-C-G-x-C-x-P-C-R-x-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.1.2
            ExPASy - ENZYME nomenclature database: 1.12.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.12.1.2
            BRENDA, the Enzyme Database: 1.12.1.2
///
ENTRY       EC 1.12.2.1
NAME        Cytochrome-c3 hydrogenase
            Hydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With a cytochrome as acceptor
SYSNAME     Hydrogen:ferricytochrome-c3 oxidoreductase
REACTION    2 H2 + Ferricytochrome c3 = 4 H+ + Ferrocytochrome c3
SUBSTRATE   H2
            Ferricytochrome c3
            Methylene blue
PRODUCT     H+
            Ferrocytochrome c3
COFACTOR    Iron
COMMENT     Contains iron. Methylene blue and other acceptors can be reduced
            with H2.
GENES       PAB: PAB0638(hydB-2) PAB0640(hydD-2) PAB1784
STRUCTURES  PDB: 1FRV  1H2R  
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.2.1
            ExPASy - ENZYME nomenclature database: 1.12.2.1
            WIT (What Is There) Metabolic Reconstruction: 1.12.2.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.12.2.1
            BRENDA, the Enzyme Database: 1.12.2.1
            SCOP (Structural Classification of Proteins): 1.12.2.1
///
ENTRY       EC 1.12.7.1
NAME        Transferred to EC 1.18.99.1
CLASS       Oxidoreductases
            Acting on hydrogen as donor
COMMENT     Transferred entry. Now EC 1.18.99.1 - Hydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.7.1
            ExPASy - ENZYME nomenclature database: 1.12.7.1
            WIT (What Is There) Metabolic Reconstruction: 1.12.7.1
///
ENTRY       EC 1.12.99.1
NAME        Coenzyme F420 hydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With other acceptors
SYSNAME     Hydrogen:(acceptor) oxidoreductase
REACTION    H2 + Coenzyme F420 = Reduced coenzyme F420
SUBSTRATE   H2
            Coenzyme F420
PRODUCT     Reduced coenzyme F420
COFACTOR    Deazaflavin
            Iron
            Nickel
COMMENT     A flavoprotein containing iron and nickel. The natural hydrogen
            acceptor, coenzyme F420, is a deazaflavin derivative.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       SYN: slr1923(frhB)
            MJA: MJ0029 MJ0030(frhD) MJ0031(frhG) MJ0032(frhB) MJ0725 MJ0726
                 MJ0727
            MTH: MTH1297(frhB) MTH1298(frhG) MTH1300(frhA) MTH193 MTH341
                 MTH737
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00507  R-G-[LIVMF]-E-x(15)-[QESM]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2,3)-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.99.1
            ExPASy - ENZYME nomenclature database: 1.12.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.12.99.1
            BRENDA, the Enzyme Database: 1.12.99.1
///
ENTRY       EC 1.12.99.2
NAME        Coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-
            $heterodisulfide hydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With other acceptors
SYSNAME     Hydrogen:coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-
            $heterodisulfide oxidoreductase
REACTION    Coenzyme M 7-mercaptoheptanoylthreonine-phosphate
            $ heterodisulfide + H2 = Coenzyme M +
            N-(7-Mercaptoheptanoyl)threonine O3-phosphate
SUBSTRATE   Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide
            H2
PRODUCT     Coenzyme M
            N-(7-Mercaptoheptanoyl)threonine O3-phosphate
COMMENT     The heterodisulfide is reduced by H2 to the two thiols. May be a
            system of two enzymes, a hydrogenase and a disulfide reductase.
PATHWAY     PATH: MAP00790  Folate biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.99.2
            ExPASy - ENZYME nomenclature database: 1.12.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.12.99.2
            BRENDA, the Enzyme Database: 1.12.99.2
///
ENTRY       EC 1.12.99.3
NAME        Hydrogen:Quinone oxidoreductase
            Hydrogen:Menaquinone oxidoreductase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With other acceptors
REACTION    H2 + Menaquinone = Reduced Menaquinone
SUBSTRATE   H2
            Menaquinone
PRODUCT     Reduced Menaquinone
COMMENT     Catalyses the reduction of water-soluble quinones (e.g. 2,3-
            Dimethylnaphthoquinone) or Viologen dyes (Benzyl viologen or
            Methyl viologen) by H2.
MOTIF       PS: PS00507  R-G-[LIVMF]-E-x(15)-[QESM]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2,3)-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.99.3
            ExPASy - ENZYME nomenclature database: 1.12.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.12.99.3
///
ENTRY       EC 1.12.99.4
NAME        N5,N10-Methenyltetrahydromethanopterin hydrogenase
            H2-Forming N5,N10-methylenetetrahydromethanopterin dehydrogenase
CLASS       Oxidoreductases
            Acting on hydrogen as donor
            With other acceptors
REACTION    N5,N10-Methenyltetrahydromethanopterin + H2 =
            N5,N10-Methylenetetrahydromethanopterin
SUBSTRATE   N5,N10-Methenyltetrahydromethanopterin
            H2
PRODUCT     N5,N10-Methylenetetrahydromethanopterin
COMMENT     Does not catalyse the reduction of artificial dyes by H2. Does not
            by itself catalyse a H2/H+ exchange reaction.
            Does not contain nickel or iron-sulfur clusters.
DBLINKS     IUBMB Enzyme Nomenclature: 1.12.99.4
            ExPASy - ENZYME nomenclature database: 1.12.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.12.99.4
///
ENTRY       EC 1.13.11.1
NAME        Catechol 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Catechol:oxygen 1,2-oxidoreductase(decyclizing)
REACTION    Catechol + O2 = cis,cis-Muconate;
            4-Methylcatechol + O2 = 3-Methyl-cis,cis-muconate
SUBSTRATE   Catechol
            O2
            4-Methylcatechol
PRODUCT     cis,cis-Muconate
            3-Methyl-cis,cis-muconate
COFACTOR    Iron
COMMENT     Requires Fe3+. Involved in the metabolism of nitro-aromatic
            compounds by a strain of Pseudomonas putida. Formerly EC 1.13.1.1
            and 1.99.2.2.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00624  Xylene degradation
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00627  1,4-Dichlorobenzene degradation
            PATH: MAP00629  Carbazole degradation
MOTIF       PS: PS00083  [LIVMF]-x-G-x-[LIVM]-x(4)-[GS]-x(2)-[LIVM]-x(4)-[LIVM]-
                         [DE]-[LIVMFYC]-x(6)-G-x-[FY]
STRUCTURES  PDB: 1DLM  1DLQ  1DLT  1DMH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.1
            ExPASy - ENZYME nomenclature database: 1.13.11.1
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.1
            BRENDA, the Enzyme Database: 1.13.11.1
            SCOP (Structural Classification of Proteins): 1.13.11.1
///
ENTRY       EC 1.13.11.2
NAME        Catechol 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Catechol:oxygen 2,3-oxidoreductase(decyclizing)
REACTION    Catechol + O2 = 2-Hydroxymuconate semialdehyde;
            4-Methylcatechol + O2 =
            2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
SUBSTRATE   Catechol
            O2
            4-Methylcatechol
PRODUCT     2-Hydroxymuconate semialdehyde
            2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
COFACTOR    Iron
COMMENT     Requires Fe2+. Formerly EC 1.13.1.2.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
            PATH: MAP00624  Xylene degradation
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00629  Carbazole degradation
            PATH: MAP00643  Styrene degradation
GENES       SSO: SSO1223 SSO2054
            STO: ST0724
MOTIF       PS: PS00082  [GNTIV]-x-H-x(5,7)-[LIVMF]-Y-x(2)-[DENTA]-P-x-[GP]-
                         x(2,3)-E
STRUCTURES  PDB: 1MPY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.2
            ExPASy - ENZYME nomenclature database: 1.13.11.2
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.2
            BRENDA, the Enzyme Database: 1.13.11.2
            SCOP (Structural Classification of Proteins): 1.13.11.2
///
ENTRY       EC 1.13.11.3
NAME        Protocatechuate 3,4-dioxygenase
            Protocatechuate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)
REACTION    3,4-Dihydroxybenzoate + O2 = 3-Carboxy-cis,cis-muconate
SUBSTRATE   3,4-Dihydroxybenzoate
            O2
PRODUCT     3-Carboxy-cis,cis-muconate
COFACTOR    Iron
COMMENT     Requires Fe3+. Formerly EC 1.13.1.3 and 1.99.2.3.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00623  2,4-Dichlorobenzoate degradation
GENES       PAE: PA0153(pcaH) PA0154(pcaG)
            RCO: RC0543
            MLO: mlr7208 mlr7210
            SME: SMb20576(pcaG) SMb20577(pcaH)
            CCR: CC2408 CC2409
MOTIF       PS: PS00083  [LIVMF]-x-G-x-[LIVM]-x(4)-[GS]-x(2)-[LIVM]-x(4)-[LIVM]-
                         [DE]-[LIVMFYC]-x(6)-G-x-[FY]
STRUCTURES  PDB: 3PCB  3PCH  1EOC  2PCD  3PCN  3PCM  3PCL  1EO2  1EO9  1EOA  
                 1EOB  3PCA  3PCK  3PCC  3PCD  3PCE  3PCF  3PCG  3PCJ  3PCI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.3
            ExPASy - ENZYME nomenclature database: 1.13.11.3
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.3
            BRENDA, the Enzyme Database: 1.13.11.3
            SCOP (Structural Classification of Proteins): 1.13.11.3
///
ENTRY       EC 1.13.11.4
NAME        Gentisate 1,2-dioxygenase
            Gentisate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Gentisate:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    2,5-Dihydroxybenzoate + O2 = Maleylpyruvate
SUBSTRATE   2,5-Dihydroxybenzoate
            O2
PRODUCT     Maleylpyruvate
COFACTOR    Iron
COMMENT     Requires Fe2+. Formerly EC 1.13.1.4 and 1.99.2.4.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.4
            ExPASy - ENZYME nomenclature database: 1.13.11.4
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.4
            BRENDA, the Enzyme Database: 1.13.11.4
///
ENTRY       EC 1.13.11.5
NAME        Homogentisate 1,2-dioxygenase
            Homogentisicase
            Homogentisate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    Homogentisate + O2 = 4-Maleylacetoacetate
SUBSTRATE   Homogentisate
            O2
PRODUCT     4-Maleylacetoacetate
COFACTOR    Iron
COMMENT     Requires Fe2+.  Formerly EC 1.13.1.5 and 1.99.2.5.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00643  Styrene degradation
GENES       PAE: PA2009(hmgA)
            MLO: mlr8303
            SME: SMc03208(hmgA)
            CCR: CC2532
            SSO: SSO1533
            CEL: W06D4.1
            DME: CG4779
            HSA: 3081(HGD)
DISEASE     MIM: 203500  Homogentisate 1,2-dioxygenase (homogentisate oxidase)
STRUCTURES  PDB: 1EY2  1EYB  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.5
            ExPASy - ENZYME nomenclature database: 1.13.11.5
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.5
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.5
            BRENDA, the Enzyme Database: 1.13.11.5
            SCOP (Structural Classification of Proteins): 1.13.11.5
///
ENTRY       EC 1.13.11.6
NAME        3-Hydroxyanthranilate 3,4-dioxygenase
            3-Hydroxyanthranilate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)
REACTION    3-Hydroxyanthranilate + O2 =
            2-Amino-3-carboxymuconate semialdehyde
SUBSTRATE   3-Hydroxyanthranilate
            O2
PRODUCT     2-Amino-3-carboxymuconate semialdehyde
COFACTOR    Iron
COMMENT     Requires Fe2+.  Formerly EC 1.13.1.6.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       SCE: YJR025C(BNA1)
            HSA: 23498(HAAO)
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.6
            ExPASy - ENZYME nomenclature database: 1.13.11.6
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.6
            BRENDA, the Enzyme Database: 1.13.11.6
///
ENTRY       EC 1.13.11.7
NAME        Deleted entry
            3,4-Dihydroxyphenylacetate 3,4-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.7
            ExPASy - ENZYME nomenclature database: 1.13.11.7
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.7
///
ENTRY       EC 1.13.11.8
NAME        Protocatechuate 4,5-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
REACTION    Protocatechuate + O2 = 4-Carboxy-2-hydroxymuconate semialdehyde
SUBSTRATE   Protocatechuate
            O2
PRODUCT     4-Carboxy-2-hydroxymuconate semialdehyde
COFACTOR    Iron
COMMENT     Requires Fe2+. Formerly EC 1.13.1.8.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00623  2,4-Dichlorobenzoate degradation
STRUCTURES  PDB: 1BOU  1B4U  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.8
            ExPASy - ENZYME nomenclature database: 1.13.11.8
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.8
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.8
            BRENDA, the Enzyme Database: 1.13.11.8
            SCOP (Structural Classification of Proteins): 1.13.11.8
///
ENTRY       EC 1.13.11.9
NAME        2,5-Dihydroxypyridine 5,6-dioxygenase
            2,5-Dihydroxypyridine oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2,5-Dihydroxypyridine:oxygen 5,6-oxidoreductase
REACTION    2,5-Dihydroxypyridine + O2 = Maleamate + Formate
SUBSTRATE   2,5-Dihydroxypyridine
            O2
PRODUCT     Maleamate
            Formate
COFACTOR    Iron
COMMENT     Requires Fe2+.  Formerly EC 1.13.1.9.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.9
            ExPASy - ENZYME nomenclature database: 1.13.11.9
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.9
            BRENDA, the Enzyme Database: 1.13.11.9
///
ENTRY       EC 1.13.11.10
NAME        7,8-Dihydroxykynurenate 8,8a-dioxygenase
            7,8-Dihydroxykynurenate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     7,8-Dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)
REACTION    7,8-Dihydroxykynurenate + O2 =
            5-(3-Carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate
SUBSTRATE   7,8-Dihydroxykynurenate
            O2
PRODUCT     5-(3-Carboxy-3-oxopropenyl)-4,6-dihydroxypyridine-2-carboxylate
COFACTOR    Iron
COMMENT     Requires Fe2+.  Formerly EC 1.13.1.10.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.10
            ExPASy - ENZYME nomenclature database: 1.13.11.10
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.10
            BRENDA, the Enzyme Database: 1.13.11.10
///
ENTRY       EC 1.13.11.11
NAME        Tryptophan 2,3-dioxygenase
            Tryptophan pyrrolase
            Tryptophanase
            Tryptophan oxygenase
            Tryptamine 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    L-Tryptophan + O2 = L-Formylkynurenine
SUBSTRATE   L-Tryptophan
            O2
            Tryptamine
            D-Tryptophan
            5-Hydroxytryptophan
            Serotonin
PRODUCT     L-Formylkynurenine
COFACTOR    Protoheme
COMMENT     A protohemoprotein. Broad specificity towards tryptamine and
            derivatives including D- and L-tryptophan, 5-hydroxytryptophan
            and serotonin.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       MLO: mlr0620
            CEL: C28H8.11
            DME: CG2155
            HSA: 6999(TDO2)
DISEASE     MIM: 191070  Tryptophan oxygenase
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.11
            ExPASy - ENZYME nomenclature database: 1.13.11.11
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.11
            BRENDA, the Enzyme Database: 1.13.11.11
///
ENTRY       EC 1.13.11.12
NAME        Lipoxygenase
            Lipoxidase
            Carotene oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Linoleate:oxygen oxidoreductase
REACTION    Linoleate + O2 =
            (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate
SUBSTRATE   Linoleate
            O2
PRODUCT     (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoate
COFACTOR    Iron
            PQQ
COMMENT     An iron protein. Also oxidizes other methylene-interrupted poly-
            unsaturated fatty acids. Formerly EC 1.13.1.13 & 1.99.2.1
            PQQ enzyme
GENES       ATH: At1g67560(F12B7.11)
MOTIF       PS: PS00081  [LIVMAC]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NEQHRC]-[GSTA]-H-[LIVMSTAC](2)-x-
                         E
STRUCTURES  PDB: 1FGQ  2SBL  1FGO  1FGR  1F8N  1YGE  1FGT  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.12
            ExPASy - ENZYME nomenclature database: 1.13.11.12
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.12
            BRENDA, the Enzyme Database: 1.13.11.12
            SCOP (Structural Classification of Proteins): 1.13.11.12
///
ENTRY       EC 1.13.11.13
NAME        Ascorbate 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving)
REACTION    Ascorbate + O2 = Oxalate + Threonate
SUBSTRATE   Ascorbate
            O2
PRODUCT     Oxalate
            Threonate
COFACTOR    Iron
COMMENT     Requires Fe2+.
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.13
            ExPASy - ENZYME nomenclature database: 1.13.11.13
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.13
            BRENDA, the Enzyme Database: 1.13.11.13
///
ENTRY       EC 1.13.11.14
NAME        2,3-Dihydroxybenzoate 3,4-dioxygenase
            o-Pyrocatechuate oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2,3-Dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)
REACTION    2,3-Dihydroxybenzoate + O2 =
            3-Carboxy-2-hydroxymuconate semialdehyde
SUBSTRATE   2,3-Dihydroxybenzoate
            O2
PRODUCT     3-Carboxy-2-hydroxymuconate semialdehyde
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.14
            ExPASy - ENZYME nomenclature database: 1.13.11.14
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.14
            BRENDA, the Enzyme Database: 1.13.11.14
///
ENTRY       EC 1.13.11.15
NAME        3,4-Dihydroxyphenylacetate 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    3,4-Dihydroxyphenylacetate + O2 =
            2-Hydroxy-5-carboxymethylmuconate semialdehyde
SUBSTRATE   3,4-Dihydroxyphenylacetate
            O2
PRODUCT     2-Hydroxy-5-carboxymethylmuconate semialdehyde
COFACTOR    Iron
COMMENT     An iron protein.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       YPE: YPO1764(hpaD)
            PMU: PM1531(hpaD)
            PAE: PA4124(hpcB)
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.15
            ExPASy - ENZYME nomenclature database: 1.13.11.15
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.15
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.15
            BRENDA, the Enzyme Database: 1.13.11.15
///
ENTRY       EC 1.13.11.16
NAME        3-Carboxyethylcatechol 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3-(2,3-Dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase
            $ (decyclizing)
REACTION    3-(2,3-Dihydroxyphenyl)propanoate + O2 =
            2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
SUBSTRATE   3-(2,3-Dihydroxyphenyl)propanoate
            O2
PRODUCT     2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
COFACTOR    Iron
COMMENT     An iron protein.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.16
            ExPASy - ENZYME nomenclature database: 1.13.11.16
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.16
            BRENDA, the Enzyme Database: 1.13.11.16
///
ENTRY       EC 1.13.11.17
NAME        Indole 2,3-dioxygenase
            Indole oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Indole:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    Indole + O2 = 2-Formylaminobenzaldehyde
SUBSTRATE   Indole
            O2
PRODUCT     2-Formylaminobenzaldehyde
            Anthranilate
COFACTOR    Flavin
            Copper
COMMENT     The enzyme from Jasminum is a flavoprotein containing copper, and
            forms anthranilate as the final product. One enzyme from Tecoma
            stans is also a flavoprotein containing copper and uses 3 atoms of
             oxygen per molecule of indole, to form anthranil
            (3,4-benzoisoxazol). A second enzyme from Tecoma stans, which is
            not a flavoprotein, uses 4 atoms of oxygen and forms anthranilate
            as the final product.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DISEASE     MIM: 147435  Indoleamine 2,3-dioxygenase
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.17
            ExPASy - ENZYME nomenclature database: 1.13.11.17
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.17
            BRENDA, the Enzyme Database: 1.13.11.17
///
ENTRY       EC 1.13.11.18
NAME        Sulfur dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Sulfur:oxygen oxidoreductase
REACTION    Sulfur + O2 + H2O = Sulfite
SUBSTRATE   Sulfur
            O2
            H2O
PRODUCT     Sulfite
COFACTOR    Iron
COMMENT     An iron protein.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.18
            ExPASy - ENZYME nomenclature database: 1.13.11.18
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.18
            BRENDA, the Enzyme Database: 1.13.11.18
///
ENTRY       EC 1.13.11.19
NAME        Cysteamine dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Cysteamine:oxygen oxidoreductase
REACTION    Cysteamine + O2 = Hypotaurine
SUBSTRATE   Cysteamine
            O2
PRODUCT     Hypotaurine
COFACTOR    Iron
COMMENT     An iron protein.
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.19
            ExPASy - ENZYME nomenclature database: 1.13.11.19
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.19
            BRENDA, the Enzyme Database: 1.13.11.19
///
ENTRY       EC 1.13.11.20
NAME        Cysteine dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     L-Cysteine:oxygen oxidoreductase
REACTION    L-Cysteine + O2 = 3-Sulfino-L-alanine
SUBSTRATE   L-Cysteine
            O2
PRODUCT     3-Sulfino-L-alanine
COFACTOR    Iron
            NADH
            NADPH
COMMENT     Requires Fe2+ and NAD(P)H.
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00430  Taurine and hypotaurine metabolism
GENES       CEL: F56F10.3
            HSA: 1036(CDO1)
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.20
            ExPASy - ENZYME nomenclature database: 1.13.11.20
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.20
            BRENDA, the Enzyme Database: 1.13.11.20
///
ENTRY       EC 1.13.11.21
NAME        beta-Carotene 15,15'-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     beta-Carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)
REACTION    beta-Carotene + O2 = 2 Retinal
SUBSTRATE   beta-Carotene
            O2
PRODUCT     Retinal
COFACTOR    Bile salt
            Iron
COMMENT     Requires bile salts and Fe2+.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.21
            ExPASy - ENZYME nomenclature database: 1.13.11.21
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.21
            BRENDA, the Enzyme Database: 1.13.11.21
///
ENTRY       EC 1.13.11.22
NAME        Caffeate 3,4-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase
            $ (decyclizing)
REACTION    3,4-Dihydroxy-trans-cinnamate + O2 =
            3-(2-Carboxyethenyl)-cis,cis-muconate
SUBSTRATE   3,4-Dihydroxy-trans-cinnamate
            O2
PRODUCT     3-(2-Carboxyethenyl)-cis,cis-muconate
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.22
            ExPASy - ENZYME nomenclature database: 1.13.11.22
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.22
            BRENDA, the Enzyme Database: 1.13.11.22
///
ENTRY       EC 1.13.11.23
NAME        2,3-Dihydroxyindole 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2,3-Dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    2,3-Dihydroxyindole + O2 = Anthranilate + CO2
SUBSTRATE   2,3-Dihydroxyindole
            O2
PRODUCT     Anthranilate
            CO2
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.23
            ExPASy - ENZYME nomenclature database: 1.13.11.23
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.23
            BRENDA, the Enzyme Database: 1.13.11.23
///
ENTRY       EC 1.13.11.24
NAME        Quercetin 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Quercetin:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    Quercetin + O2 = 2-Protocatechoylphloroglucinolcarboxylate + CO
SUBSTRATE   Quercetin
            O2
PRODUCT     2-Protocatechoylphloroglucinolcarboxylate
            CO
COFACTOR    Copper
COMMENT     A copper protein.  Quercetin is a flavonol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.24
            ExPASy - ENZYME nomenclature database: 1.13.11.24
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.24
            BRENDA, the Enzyme Database: 1.13.11.24
///
ENTRY       EC 1.13.11.25
NAME        3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
            $ 4,5-dioxygenase
            Steroid 4,5-dioxygenase
            3-Alkylcatechol 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:
            $oxygen 4,5-oxidoreductase (decyclizing)
REACTION    3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione +
            O2 = 3-Hydroxy-1,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-
            $dien-4-oate
SUBSTRATE   3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
            O2
            3-Isopropylcatechol
            3-tert-Butyl-5-methylcatechol
PRODUCT     3-Hydroxy-1,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-
            $dien-4-oate
COFACTOR    Iron
COMMENT     Requires Fe2+. Also acts on 3-isopropylcatechol and
            3-tert-butyl-5-methylcatechol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.25
            ExPASy - ENZYME nomenclature database: 1.13.11.25
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.25
            BRENDA, the Enzyme Database: 1.13.11.25
///
ENTRY       EC 1.13.11.26
NAME        Peptide-tryptophan 2,3-dioxygenase
            Pyrrolooxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    Peptide tryptophan + O2 = Peptide formylkynurenine
SUBSTRATE   Peptide tryptophan
            O2
            Tryptophan
PRODUCT     Peptide formylkynurenine
            Formylkynurenine
COMMENT     Also acts on tryptophan
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.26
            ExPASy - ENZYME nomenclature database: 1.13.11.26
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.26
            BRENDA, the Enzyme Database: 1.13.11.26
///
ENTRY       EC 1.13.11.27
NAME        4-Hydroxyphenylpyruvate dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,
            decarboxylating)
REACTION    3-(4-Hydroxyphenyl)pyruvate + O2 = Homogentisate + CO2
SUBSTRATE   3-(4-Hydroxyphenyl)pyruvate
            O2
PRODUCT     Homogentisate
            CO2
COMMENT     The Pseudomonas enzyme contains one Fe3+ per mole of enzyme; the
            enzymes from other sources may contain essential iron or copper.
            Formerly EC 1.14.2.2 and 1.99.1.14.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
GENES       VCH: VC1344
            PAE: PA0865(hpd)
            MLO: mll8309
            SME: SMb20581 SMc03211
            CCR: CC2533
            SYN: slr0090(ppd)
            ATH: At1g06620(F12K11.24)
            CEL: T21C12.2
            DME: CG11796
            HSA: 3242(HPD)
DISEASE     MIM: 276710  4-hydroxyphenylpyruvate dioxygenase
STRUCTURES  PDB: 1CJX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.27
            ExPASy - ENZYME nomenclature database: 1.13.11.27
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.27
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.27
            BRENDA, the Enzyme Database: 1.13.11.27
            SCOP (Structural Classification of Proteins): 1.13.11.27
///
ENTRY       EC 1.13.11.28
NAME        2,3-Dihydroxybenzoate 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2,3-Dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)
REACTION    2,3-Dihydroxybenzoate + O2 = 2-Carboxy-cis,cis-muconate
SUBSTRATE   2,3-Dihydroxybenzoate
            O2
PRODUCT     2-Carboxy-cis,cis-muconate
COMMENT     Also acts, more slowly, with 2,3-dihydroxy-4-methylbenzoate and
            2,3-dihydroxy-4-isopropylbenzoate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.28
            ExPASy - ENZYME nomenclature database: 1.13.11.28
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.28
            BRENDA, the Enzyme Database: 1.13.11.28
///
ENTRY       EC 1.13.11.29
NAME        Stizolobate synthase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase
            $ (recyclizing)
REACTION    3,4-Dihydroxy-L-phenylalanine + O2 =
            4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
SUBSTRATE   3,4-Dihydroxy-L-phenylalanine
            O2
PRODUCT     4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
COFACTOR    Zinc
COMMENT     The intermediate product undergoes ring closure and oxidation,
            with NAD(P)+ as acceptor, to stizolobic acid. The enzyme requires
            Zn2+.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.29
            ExPASy - ENZYME nomenclature database: 1.13.11.29
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.29
            BRENDA, the Enzyme Database: 1.13.11.29
///
ENTRY       EC 1.13.11.30
NAME        Stizolobinate synthase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase
            $ (recyclizing)
REACTION    3,4-Dihydroxy-L-phenylalanine + O2 =
            5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
SUBSTRATE   3,4-Dihydroxy-L-phenylalanine
            O2
PRODUCT     5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
COFACTOR    Zinc
COMMENT     The intermediate product undergoes ring closure and oxidation,
            with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme
            requires Zn2+.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.30
            ExPASy - ENZYME nomenclature database: 1.13.11.30
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.30
            BRENDA, the Enzyme Database: 1.13.11.30
///
ENTRY       EC 1.13.11.31
NAME        Arachidonate 12-lipoxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 12-oxidoreductase
REACTION    Arachidonate + O2 =
            (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate
INHIBITOR   3-Methoxytropolone
COMMENT     The product is rapidly reduced to the corresponding 12S-hydroxy
            compound.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 87997(Alox15) 87998(Alox12)
            HSA: 239(ALOX12)
DISEASE     MIM: 152391  Arachidonate 12-lipoxygenase
MOTIF       PS: PS00081  [LIVMAC]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NEQHRC]-[GSTA]-H-[LIVMSTAC](2)-x-
                         E
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.31
            ExPASy - ENZYME nomenclature database: 1.13.11.31
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.31
            BRENDA, the Enzyme Database: 1.13.11.31
///
ENTRY       EC 1.13.11.32
NAME        2-Nitropropane dioxygenase
            Nitroalkane oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2-Nitropropane:oxygen 2-oxidoreductase
REACTION    2 2-Nitropropane + O2 = 2 Acetone + 2 Nitrite
SUBSTRATE   2-Nitropropane
            O2
PRODUCT     Acetone
            Nitrite
COFACTOR    Iron
COMMENT     An iron flavoprotein. Some other nitroalkanes, including
            nitroethane, 1-nitropropane and 3-nitro-2-pentanol, can act as
            donors, more slowly.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       AFU: AF2173(ncd2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.32
            ExPASy - ENZYME nomenclature database: 1.13.11.32
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.32
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.32
            BRENDA, the Enzyme Database: 1.13.11.32
///
ENTRY       EC 1.13.11.33
NAME        Arachidonate 15-lipoxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 15-oxidoreductase
REACTION    Arachidonate + O2 =
            (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate
COMMENT     The product is rapidly reduced to the corresponding 15S-hydroxy
            compound.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: 246(ALOX15) 247(ALOX15B)
DISEASE     MIM: 152392  Arachidonate 15-lipoxygenase
MOTIF       PS: PS00081  [LIVMAC]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NEQHRC]-[GSTA]-H-[LIVMSTAC](2)-x-
                         E
STRUCTURES  PDB: 1LOX  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.33
            ExPASy - ENZYME nomenclature database: 1.13.11.33
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.33
            BRENDA, the Enzyme Database: 1.13.11.33
            SCOP (Structural Classification of Proteins): 1.13.11.33
///
ENTRY       EC 1.13.11.34
NAME        Arachidonate 5-lipoxygenase
            Leukotriene-A4 synthase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 5-oxidoreductase
REACTION    Arachidonate + O2 =
            (6Z,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate;
            Arachidonate + O2 =
            5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (6Z,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate
            (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
            Leukotriene A4
INHIBITOR   Caffeic acid
            AA861
            2-Heptyl-4-hydroxyquinoline-N-oxide
COMMENT     The product shown above is further converted by the enzyme into
            (7Z,9E,11Z,14Z)-(5S,6S)-5,6-epoxyeicosa-7,9,11,14-tetraenoate
            (leukotriene A4).
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 87999(Alox5)
            HSA: 240(ALOX5)
DISEASE     MIM: 152390  Arachidonate 5-lipoxygenase
MOTIF       PS: PS00081  [LIVMAC]-H-P-[LIVM]-x-[KRQ]-[LIVMF](2)-x-[AP]-H
            PS: PS00711  H-[EQ]-x(3)-H-x-[LM]-[NEQHRC]-[GSTA]-H-[LIVMSTAC](2)-x-
                         E
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.34
            ExPASy - ENZYME nomenclature database: 1.13.11.34
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.34
            BRENDA, the Enzyme Database: 1.13.11.34
///
ENTRY       EC 1.13.11.35
NAME        Pyrogallol 1,2-oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     1,2,3-Trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    1,2,3-Trihydroxybenzene + O2 = (Z)-5-Oxohex-2-enedioate
SUBSTRATE   1,2,3-Trihydroxybenzene
            O2
PRODUCT     (Z)-5-Oxohex-2-enedioate
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.35
            ExPASy - ENZYME nomenclature database: 1.13.11.35
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.35
            BRENDA, the Enzyme Database: 1.13.11.35
///
ENTRY       EC 1.13.11.36
NAME        Chloridazon-catechol dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     5-Amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone
            $ 1,2-oxidoreductase (decyclizing)
REACTION    5-Amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone + CO2 =
            5-Amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone
SUBSTRATE   5-Amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone
            CO2
PRODUCT     5-Amino-4-chloro-2-(2-hydroxymuconoyl)-3(2H)-pyridazinone
COFACTOR    Iron
COMMENT     An iron protein, requiring additional Fe2+. Not identical with
            EC 1.13.11.1, 1.13.12.2or 1.13.11.5. Involved in the breakdown of
            the herbicide chloridazon.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.36
            ExPASy - ENZYME nomenclature database: 1.13.11.36
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.36
            BRENDA, the Enzyme Database: 1.13.11.36
///
ENTRY       EC 1.13.11.37
NAME        Hydroxyquinol 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    Benzene-1,2,4-triol + O2 = 3-Hydroxy-cis,cis-muconate
SUBSTRATE   Benzene-1,2,4-triol
            O2
PRODUCT     3-Hydroxy-cis,cis-muconate
COFACTOR    Iron
COMMENT     An iron protein. The product isomerizes to 2-maleylacetate
            (cis-hexenedioate). Highly specific; catechol and pyrogallol are
            acted on at less than 1% of the rate at which hydroxyquinol is
            oxidized.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00627  1,4-Dichlorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.37
            ExPASy - ENZYME nomenclature database: 1.13.11.37
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.37
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.37
            BRENDA, the Enzyme Database: 1.13.11.37
///
ENTRY       EC 1.13.11.38
NAME        1-Hydroxy-2-naphthoate 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     1-Hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    1-Hydroxy-2-naphthoate + O2 =
            (3E)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate
SUBSTRATE   1-Hydroxy-2-naphthoate
            O2
PRODUCT     (3E)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate
COFACTOR    Iron
COMMENT     Requires Fe2+. Involved, with EC 4.1.2.34, in the metabolism of
            phenanthrene in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.38
            ExPASy - ENZYME nomenclature database: 1.13.11.38
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.38
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.38
            BRENDA, the Enzyme Database: 1.13.11.38
///
ENTRY       EC 1.13.11.39
NAME        Biphenyl-2,3-diol 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)
REACTION    Biphenyl-2,3-diol + O2 = 2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
             + H2O
SUBSTRATE   Biphenyl-2,3-diol
            O2
            3-Isopropylcatechol
PRODUCT     2-Hydroxy-6-oxo-6-phenylhexa-2,4-dienoate
            H2O
            7-Methyl-2-hydroxy-6-oxoocta-2,4-dienoate
COMMENT     Also act on 3-isopropylcatechol, forming 7-methyl-2-hydroxy-
            -6-oxoocta-2,4-dienoate. Not identical with EC 1.13.11.2.
PATHWAY     PATH: MAP00621  Biphenyl degradation
MOTIF       PS: PS00082  [GNTIV]-x-H-x(5,7)-[LIVMF]-Y-x(2)-[DENTA]-P-x-[GP]-
                         x(2,3)-E
STRUCTURES  PDB: 1DHY  1EIL  1GDG  1HAN  1EIM  1EIQ  1EIR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.39
            ExPASy - ENZYME nomenclature database: 1.13.11.39
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.39
            UM-BBD (Biocatalysis/Biodegradation Database): 1.13.11.39
            BRENDA, the Enzyme Database: 1.13.11.39
            SCOP (Structural Classification of Proteins): 1.13.11.39
///
ENTRY       EC 1.13.11.40
NAME        Arachidonate 8-lipoxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Arachidonate:oxygen 8-oxidoreductase
REACTION    Arachidonate + O2 =
            (5Z,9E,11Z,14Z)-(8R)-8-Hydroxyperoxyeicosa-5,9,11,14-tetraenoate
SUBSTRATE   Arachidonate
            O2
PRODUCT     (5Z,9E,11Z,14Z)-(8R)-8-Hydroxyperoxyeicosa-5,9,11,14-tetraenoate
COMMENT     From the coral Pseudoplexaura porosa.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.40
            ExPASy - ENZYME nomenclature database: 1.13.11.40
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.40
            BRENDA, the Enzyme Database: 1.13.11.40
///
ENTRY       EC 1.13.11.41
NAME        2,4'-Dihydroxyacetophenone dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     2,4'-Dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)
REACTION    2,4'-Dihydroxyacetophenone + O2 = 4-Hydroxybenzoate + Formate
SUBSTRATE   2,4'-Dihydroxyacetophenone
            O2
PRODUCT     4-Hydroxybenzoate
            Formate
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.41
            ExPASy - ENZYME nomenclature database: 1.13.11.41
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.41
            BRENDA, the Enzyme Database: 1.13.11.41
///
ENTRY       EC 1.13.11.42
NAME        Indoleamine-pyrrole 2,3-dioxygenase
            Indoleamine 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     Indoleamine:oxygen 2,3-dioxygenase (indole-decyclizing)
REACTION    L-Tryptophan + O2 = N-Formylkynurenine
SUBSTRATE   L-Tryptophan
            O2
            Indoleamine
            Melatonin
PRODUCT     N-Formylkynurenine
COMMENT     Acts on many substituted and unsubstituted indoleamines, including
            melatonin. Involved in the degradation of melatonin.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       HSA: 3620(INDO)
MOTIF       PS: PS00876  G-G-S-[AN]-[GA]-Q-S-S-x(2)-Q
            PS: PS00877  [FY]-L-[DQ]-[DE]-[LIVM]-x(2)-Y-M-x(3)-H-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.42
            ExPASy - ENZYME nomenclature database: 1.13.11.42
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.42
            BRENDA, the Enzyme Database: 1.13.11.42
///
ENTRY       EC 1.13.11.43
NAME        Lignostilbene alpha beta-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
SYSNAME     1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase
            $ (alpha-beta-bond-cleaving)
REACTION    1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene + O2 = 2 Vanillin
SUBSTRATE   1,2-Bis(4-hydroxy-3-methoxyphenyl)ethylene
            O2
PRODUCT     Vanillin
COFACTOR    Iron
COMMENT     An iron protein. The enzyme catalyses oxidatinve cleavage of the
            interphenyl double bond in the synthetic substrate and
            lignin-derived stilbenes. It is responsible for the degradation
            of a diarylpropane-type structure in lignin.
GENES       SYN: sll1541
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.43
            ExPASy - ENZYME nomenclature database: 1.13.11.43
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.43
            BRENDA, the Enzyme Database: 1.13.11.43
///
ENTRY       EC 1.13.11.44
NAME        4-Hydroxycatechol 1,2-dioxygenase
            6-Chlorohydroxyquinol 1,2-dioxygenase
            Hydroxyquinol 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of two atoms of oxygen
REACTION    Benzene-1,2,4-triol + O2 = 2-Maleylacetate;
            6-Chlorobenzene-1,2,4-triol + O2 = 2-Chloromaleylacetate
SUBSTRATE   Benzene-1,2,4-triol
            O2
            6-Chlorobenzene-1,2,4-triol
PRODUCT     2-Maleylacetate
            2-Chloromaleylacetate
COMMENT     4-hydroxycatechol is benzene-1,2,4-triol.
            Catalyses ortho-cleavage of the benzene nucleus.
            6-chlorobenzene-1,2,4-triol (6-chlorohydroxyquinol) is also a
            substrate, yielding 2-chloromaleylacetate, but catechol,
            chlorinated catechols, hydroquinone, chlorinated hydroquinones and
            pyrogallol are not.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.11.44
            ExPASy - ENZYME nomenclature database: 1.13.11.44
            WIT (What Is There) Metabolic Reconstruction: 1.13.11.44
///
ENTRY       EC 1.13.12.1
NAME        Arginine 2-monooxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     L-Arginine:oxygen 2-oxidoreductase (decarboxylating)
REACTION    L-Arginine + O2 = 4-Guanidinobutanamide + CO2 + H2O
SUBSTRATE   L-Arginine
            O2
            Canavanine
            Homoarginine
PRODUCT     4-Guanidinobutanamide
            CO2
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein.  Also acts on canavanine and homoarginine.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.1
            ExPASy - ENZYME nomenclature database: 1.13.12.1
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.1
            BRENDA, the Enzyme Database: 1.13.12.1
///
ENTRY       EC 1.13.12.2
NAME        Lysine 2-monooxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     L-Lysine:oxygen 2-oxidoreductase (decarboxylating)
REACTION    L-Lysine + O2 = 5-Aminopentanamide + CO2 + H2O
SUBSTRATE   L-Lysine
            O2
PRODUCT     5-Aminopentanamide
            CO2
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Also acts on other diamino acids.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.2
            ExPASy - ENZYME nomenclature database: 1.13.12.2
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.2
            BRENDA, the Enzyme Database: 1.13.12.2
///
ENTRY       EC 1.13.12.3
NAME        Tryptophan 2-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     L-Tryptophan:oxygen 2-oxidoreductase(decarboxylating)
REACTION    L-Tryptophan + O2 = Indole-3-acetamide + CO2 + H2O
SUBSTRATE   L-Tryptophan
            O2
PRODUCT     Indole-3-acetamide
            CO2
            H2O
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.3
            ExPASy - ENZYME nomenclature database: 1.13.12.3
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.3
            BRENDA, the Enzyme Database: 1.13.12.3
///
ENTRY       EC 1.13.12.4
NAME        Lactate 2-monooxygenase
            Lactate oxidative decarboxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     (S)-Lactate:oxygen 2-oxidoreductase(decarboxylating)
REACTION    (S)-Lactate + O2 = Acetate + CO2 + H2O
SUBSTRATE   (S)-Lactate
            O2
PRODUCT     Acetate
            CO2
            H2O
COFACTOR    FMN
COMMENT     A flavoprotein (FMN). Formerly EC 1.1.3.2.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       CCR: CC1396
MOTIF       PS: PS00557  S-N-H-G-[AG]-R-Q
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.4
            ExPASy - ENZYME nomenclature database: 1.13.12.4
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.4
            BRENDA, the Enzyme Database: 1.13.12.4
///
ENTRY       EC 1.13.12.5
NAME        Renilla-luciferin 2-monooxygenase
            Renilla-type luciferase
            Aequorin
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)
REACTION    Renilla luciferin + O2 = Oxidized Renilla luciferin + CO2 + hv
SUBSTRATE   Renilla luciferin
            O2
            8-Benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo-
            $[1,2a]pyrazin-3(7H)-one
PRODUCT     Oxidized Renilla luciferin
            CO2
            hv
COMMENT     8-Benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo-
            [1,2a]pyrazin-3(7H)-one is similar to, and as active as, luciferin
            from the coelenterate Renilla. The native luciferin has the benzyl
            group replaced by an unidentified group of approximately
            200 Da. Luciferases of other coelenterates also react with
            Renilla luciferin. The enzyme may be assayed by measurement
            of light emission.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.5
            ExPASy - ENZYME nomenclature database: 1.13.12.5
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.5
            BRENDA, the Enzyme Database: 1.13.12.5
///
ENTRY       EC 1.13.12.6
NAME        Cypridina-luciferin 2-monooxygenase
            Cypridina-type luciferase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     Cypridina-luciferin:oxygen 2-oxidoreductase(decarboxylating)
REACTION    Cypridina luciferin + O2 = Oxidized Cypridina luciferin +
            CO2 + hv
SUBSTRATE   Cypridina luciferin
            O2
PRODUCT     Oxidized Cypridina luciferin
            CO2
            hv
COMMENT     Luciferin from the bioluminescent crustacean Cypridina is
            [3-[3,7-dihydro-6-(1H-indol-3-yl)]-2-[(S)-1-methyl-6-propyl]-
            -3-oxoimidazo[1,2a]pyrazin-8-yl]propyl]guanidine. The luciferins
            (and presumably the luciferases, since they cross react) of some
            luminous fish (e.g. Apogon, Parapriacanthus, Porichthys) are
            apparently similar. The enzyme may be assayed by measurement of
            light emmission.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.6
            ExPASy - ENZYME nomenclature database: 1.13.12.6
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.6
            BRENDA, the Enzyme Database: 1.13.12.6
///
ENTRY       EC 1.13.12.7
NAME        Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
            Firefly luciferase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     Photinus-luciferin:oxygen 4-oxidoreductase(decarboxylating,
            ATP-hydrolysing)
REACTION    Photinus luciferin + O2 + ATP = Oxidized Photinus luciferin +
            CO2 + H2O + AMP + Pyrophosphate + hv
SUBSTRATE   Photinus luciferin
            (S)-4,5-Dihydro-2-(6-hydroxy-2-benzothiazolyl)-4-
            $thiazolecarboxylic acid
            O2
            ATP
PRODUCT     Oxidized Photinus luciferin
            CO2
            H2O
            AMP
            Pyrophosphate
            hv
COMMENT     Photinus luciferin is (S)-4,5-dihydro-2-(6-hydroxy-2-benzothia-
            zolyl)-4-thiazolecarboxylic acid. The first step in the reaction
            is the formation of an acid anhydride between the carboxylic
            group and AMP, with the release of pyrophosphate. The enzyme
            may be assayed by measurement of light emission.
GENES       DME: CG6178
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
STRUCTURES  PDB: 1LCI  1BA3  
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.7
            ExPASy - ENZYME nomenclature database: 1.13.12.7
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.7
            BRENDA, the Enzyme Database: 1.13.12.7
            SCOP (Structural Classification of Proteins): 1.13.12.7
///
ENTRY       EC 1.13.12.8
NAME        Watasemia-luciferin 2-monooxygenase
            Watasemia-type luciferase
            Luciferase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)
REACTION    Watasenia luciferin + O2 = Oxidized Watasenia luciferin + CO2 + hv
SUBSTRATE   Watasenia luciferin
            O2
PRODUCT     Oxidized Watasenia luciferin
            CO2
            hv
COMMENT     Luciferin from the luminous squid Watasenia is 8-(phenylmethyl)-6-
            -(4-sulfooxyphenyl)-2-[(4-sulfo-oxyphenyl)methyl]imidazo[1,2a]-
            pyrazin-3(7H)-one.  The enzyme may be assayed be measurement of
            light emission.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.8
            ExPASy - ENZYME nomenclature database: 1.13.12.8
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.8
            BRENDA, the Enzyme Database: 1.13.12.8
///
ENTRY       EC 1.13.12.9
NAME        Phenylalanine 2-monooxygenase
            L-Phenylalanine oxidase (deaminating and decarboxylating)
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     L-Phenylalanine:oxygen 2-oxidoreductase (decarboxylating)
REACTION    L-Phenylalanine + O2 = 2-Phenylacetamide + CO2 + H2O
SUBSTRATE   L-Phenylalanine
            O2
PRODUCT     2-Phenylacetamide
            CO2
            H2O
COMMENT     Also catalyses a reaction similar to that of EC 1.4.3.2, forming
            3-phenylpyruvate, NH3 and H2O2, but more slowly.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.9
            ExPASy - ENZYME nomenclature database: 1.13.12.9
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.9
            BRENDA, the Enzyme Database: 1.13.12.9
///
ENTRY       EC 1.13.12.10
NAME        Lysine 6-monooxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     L-Lysine:oxygen monooxygenase (6-hydroxylating)
REACTION    L-Lysine + O2 = N6-Hydroxy-L-lysine + H2O
SUBSTRATE   L-Lysine
            O2
PRODUCT     N6-Hydroxy-L-lysine
            H2O
COMMENT     Involved in the synthesis of aerobactin from lysine in a strain
            of Escherichia coli.
PATHWAY     PATH: MAP00310  Lysine degradation
GENES       YPE: YPO0993(iucD)
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.10
            ExPASy - ENZYME nomenclature database: 1.13.12.10
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.10
            BRENDA, the Enzyme Database: 1.13.12.10
///
ENTRY       EC 1.13.12.11
NAME        Methylphenyltetrahydropyridine N-monooxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen
            $ N-oxidoreductase
REACTION    1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine + O2 =
            1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + Methanol
SUBSTRATE   1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
            O2
PRODUCT     1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide
            Methanol
COFACTOR    FAD
COMMENT     A flavoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.11
            ExPASy - ENZYME nomenclature database: 1.13.12.11
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.11
            BRENDA, the Enzyme Database: 1.13.12.11
///
ENTRY       EC 1.13.12.12
NAME        apo-beta-Carotenoid-14',13'-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            With incorporation of one atom of oxygen (internal monooxygenases
            or internal mixed function oxidases)
SYSNAME     8'-apo-beta-Carotenol:O2 oxidoreductase
REACTION    8'-apo-beta-Carotenol + O2 = 14'-apo-beta-Carotenal + H2O
SUBSTRATE   8'-apo-beta-Carotenol
            O2
PRODUCT     14'-apo-beta-Carotenal
            H2O
COMMENT     A thiol-dependent enzyme. Unlike beta-carotene-15,15'-dioxygenase
            (EC 1.13.11.21), it is not active towards beta-carotene.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.12.12
            ExPASy - ENZYME nomenclature database: 1.13.12.12
            WIT (What Is There) Metabolic Reconstruction: 1.13.12.12
///
ENTRY       EC 1.13.99.1
NAME        myo-Inositol oxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
SYSNAME     myo-Inositol:oxygen oxidoreductase
REACTION    myo-Inositol + O2 = D-Glucuronate + H2O
SUBSTRATE   myo-Inositol
            O2
PRODUCT     D-Glucuronate
            H2O
COFACTOR    Iron
COMMENT     An iron protein.  Formerly EC 1.13.1.11 and 1.99.2.6.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.99.1
            ExPASy - ENZYME nomenclature database: 1.13.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.1
            BRENDA, the Enzyme Database: 1.13.99.1
///
ENTRY       EC 1.13.99.2
NAME        Transferred to EC 1.14.12.10
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
COMMENT     Transferred entry. Now EC 1.14.12.10 - Benzoate 1,2-dioxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.99.2
            ExPASy - ENZYME nomenclature database: 1.13.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.2
///
ENTRY       EC 1.13.99.3
NAME        Tryptophan 2'-dioxygenase
            Indole-3-alkane alpha-hydroxylase
            Tryptophan side-chain alpha,beta-oxidase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
SYSNAME     L-Tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)
REACTION    L-Tryptophan + O2 = 3-Indoleglycolaldehyde + CO2 + NH3
SUBSTRATE   L-Tryptophan
            O2
            5-Hydroxy-L-tryptophan
PRODUCT     3-Indoleglycolaldehyde
            CO2
            NH3
COFACTOR    Heme
COMMENT     A hemoprotein.  Acts on a number of indolyl-3-alkane derivatives,
            oxidizing the 3-side-chain in the 2'-position.  Best substrates
            were L-tryptophan and 5-hydroxy-L-tryptophan.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.99.3
            ExPASy - ENZYME nomenclature database: 1.13.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.3
            BRENDA, the Enzyme Database: 1.13.99.3
///
ENTRY       EC 1.13.99.4
NAME        Transferred to EC 1.14.12.9
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
COMMENT     Transferred entry. Now EC 1.14.12.9 - 4-Chlorophenylacetate
            3,4-dioxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.99.4
            ExPASy - ENZYME nomenclature database: 1.13.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.4
///
ENTRY       EC 1.13.99.5
NAME        3,4-Dihydroxyquinoline 2,4-dioxygenase
            1H-3-Hydroxy-4-oxoquinoline 2,4-dioxygenase
            3-Hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase
            3-Hydroxy-4(1H)-one, 2,4-dioxygenase
            Quinoline-3,4-diol 2,4-dioxygenase
CLASS       Oxidoreductases
            Acting on single donors with incorporation of molecular oxygen
            (oxygenases)
            Miscellaneous
REACTION    Quinoline-3,4-diol + O2 = N-Formylanthranilate + CO;
            2-Methylquinoline-3,4-diol + O2 = N-Acetylanthranilate + CO
SUBSTRATE   Quinoline-3,4-diol
            O2
            2-Methylquinoline-3,4-diol
PRODUCT     N-Formylanthranilate
            CO
            N-Acetylanthranilate
COMMENT     Fission of two C-C bonds: 2,4-dioxygenolytic cleavage with
            concomitant release of carbon monoxide.
            Since quinolin-4-ols exist largely as their quinolin-4(1H)-one
            tautomers, the substrate can also be called 3-hydroxy-4-oxo-1,4-
            dihydroquinoline.
            Although the enzyme from Pseudomonas putida appears to be highly
            specific for this substrate, that from Arthrobacter also acts on
            2-methylquinoline-3,4-diol to form N-acetylanthranilate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.13.99.5
            ExPASy - ENZYME nomenclature database: 1.13.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.13.99.5
///
ENTRY       EC 1.14.11.1
NAME        gamma-Butyrobetaine dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     4-Trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    4-Trimethylammoniobutanoate + 2-Oxoglutarate + O2 =
            3-Hydroxy-4-trimethylammoniobutanoate + Succinate + CO2
SUBSTRATE   4-Trimethylammoniobutanoate
            2-Oxoglutarate
            O2
PRODUCT     3-Hydroxy-4-trimethylammoniobutanoate
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00310  Lysine degradation
GENES       MLO: mll1440
            CEL: D2089.5 M05D6.7
            HSA: 8424(BBOX1)
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.1
            ExPASy - ENZYME nomenclature database: 1.14.11.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.1
            BRENDA, the Enzyme Database: 1.14.11.1
///
ENTRY       EC 1.14.11.2
NAME        Procollagen-proline dioxygenase
            Protocollagen hydroxylase
            Proline hydroxylase
            Proline,2-oxoglutarate 4-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
            (4-hydroxylating)
REACTION    Procollagen L-proline + 2-Oxoglutarate + O2 =
            Procollagen trans-4-hydroxy-L-proline + Succinate + CO2
SUBSTRATE   Procollagen L-proline
            2-Oxoglutarate
            O2
            L-Proline
PRODUCT     Procollagen trans-4-hydroxy-L-proline
            Succinate
            CO2
            trans-4-Hydroxy-L-proline
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       CEL: F35G2.4 Y47D3B.10
            DME: CG9726
            HSA: 5033(P4HA1)
DISEASE     MIM: 176710  Procollagen-proline, 2-oxoglutarate 4-dioxygenase
                         (proline
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.2
            ExPASy - ENZYME nomenclature database: 1.14.11.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.2
            BRENDA, the Enzyme Database: 1.14.11.2
///
ENTRY       EC 1.14.11.3
NAME        Pyrimidine-deoxynucleoside 2'-dioxygenase
            Thymidine 2'-hydroxylase
            Thymidine 2-oxoglutarate dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     2-Deoxyuridine,2-oxoglutarate:oxygen oxidoreductase
            $ (2'-hydroxylating)
REACTION    2-Deoxyuridine + 2-Oxoglutarate + O2 = Uridine + Succinate + CO2
SUBSTRATE   2-Deoxyuridine
            2-Oxoglutarate
            O2
            Thymidine
PRODUCT     Uridine
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate. Also acts on thymidine. cf.
            EC 1.14.11.10.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.3
            ExPASy - ENZYME nomenclature database: 1.14.11.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.3
            BRENDA, the Enzyme Database: 1.14.11.3
///
ENTRY       EC 1.14.11.4
NAME        Procollagen-lysine 5-dioxygenase
            Lysine hydroxylase
            Lysine,2-oxoglutarate 5-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase
            (5-hydroxylating)
REACTION    Procollagen L-lysine + 2-Oxoglutarate + O2 =
            Procollagen 5-hydroxy-L-lysine + Succinate + CO2
SUBSTRATE   Procollagen L-lysine
            2-Oxoglutarate
            O2
            L-Lysine
PRODUCT     Procollagen 5-hydroxy-L-lysine
            Succinate
            CO2
            5-Hydroxy-L-lysine
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00310  Lysine degradation
GENES       CEL: F52H3.1(daf-19)
            DME: CG6199
            HSA: 5351(PLOD) 5352(PLOD2) 8985(PLOD3)
DISEASE     MIM: 153454  Procollagen-lysine, 2-oxoglutarate 5-dioxygenase
                         (lysine hydroxylase)
MOTIF       PS: PS01325  P-H-H-D-[SA]-S-T-F
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.4
            ExPASy - ENZYME nomenclature database: 1.14.11.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.4
            BRENDA, the Enzyme Database: 1.14.11.4
///
ENTRY       EC 1.14.11.5
NAME        Deleted entry
            5-Hydroxymethyluracil,2-oxoglutarate dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
COMMENT     Deleted entry. Now included with EC 1.14.11.6.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.5
            ExPASy - ENZYME nomenclature database: 1.14.11.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.5
///
ENTRY       EC 1.14.11.6
NAME        Thymine dioxygenase
            Thymine 7-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
REACTION    Thymine + 2-Oxoglutarate + O2 = 5-Hydroxymethyluracil +
            Succinate + CO2
SUBSTRATE   Thymine
            2-Oxoglutarate
            O2
PRODUCT     5-Hydroxymethyluracil
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil
            to oxidize its -CH2OH group first to -CHO and then to -COOH.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.6
            ExPASy - ENZYME nomenclature database: 1.14.11.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.6
            BRENDA, the Enzyme Database: 1.14.11.6
///
ENTRY       EC 1.14.11.7
NAME        Procollagen-proline 3-dioxygenase
            Proline,2-oxoglutarate 3-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    Procollagen L-proline + 2-Oxoglutarate + O2 =
            Procollagen trans-3-hydroxy-L-proline + Succinate + CO2
SUBSTRATE   Procollagen L-proline
            2-Oxoglutarate
            O2
PRODUCT     Procollagen trans-3-hydroxy-L-proline
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.7
            ExPASy - ENZYME nomenclature database: 1.14.11.7
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.7
            BRENDA, the Enzyme Database: 1.14.11.7
///
ENTRY       EC 1.14.11.8
NAME        Trimethyllysine dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     N6,N6,N6-Trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    N6,N6,N6-Trimethyl-L-lysine + 2-Oxoglutarate + O2 =
            3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Succinate + CO2
SUBSTRATE   N6,N6,N6-Trimethyl-L-lysine
            2-Oxoglutarate
            O2
PRODUCT     3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.8
            ExPASy - ENZYME nomenclature database: 1.14.11.8
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.8
            BRENDA, the Enzyme Database: 1.14.11.8
///
ENTRY       EC 1.14.11.9
NAME        Naringenin 3-dioxygenase
            Flavanone 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
REACTION    Naringenin + 2-Oxoglutarate + O2 = Dihydrokaempferol +
            Succinate + CO2
SUBSTRATE   Naringenin
            2-Oxoglutarate
            O2
PRODUCT     Dihydrokaempferol
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.9
            ExPASy - ENZYME nomenclature database: 1.14.11.9
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.9
            BRENDA, the Enzyme Database: 1.14.11.9
///
ENTRY       EC 1.14.11.10
NAME        Pyrimidine-deoxynucleoside 1'-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     2-Deoxyuridine,2-Oxoglutarate:oxygen oxidoreductase
            $ (1'-hydroxylating)
REACTION    2-Deoxyuridine + 2-Oxoglutarate + O2 = Uracil +
            Deoxyribonolactone + Succinate + CO2
SUBSTRATE   2-Deoxyuridine
            2-Oxoglutarate
            O2
PRODUCT     Uracil
            Deoxyribonolactone
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.  cf. EC 1.14.11.3.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.10
            ExPASy - ENZYME nomenclature database: 1.14.11.10
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.10
            BRENDA, the Enzyme Database: 1.14.11.10
///
ENTRY       EC 1.14.11.11
NAME        Hyoscyamine (6S)-dioxygenase
            Hyoscyamine 6beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     L-Hyoscyamine,2-oxoglytarate:oxygen oxidoreductase
            ((6S)-hydroxylating)
REACTION    L-Hyoscyamine + 2-Oxoglutarate + O2 = (6S)-Hydroxyhyoscyamine +
            Succinate + CO2
SUBSTRATE   L-Hyoscyamine
            2-Oxoglutarate
            O2
PRODUCT     (6S)-Hydroxyhyoscyamine
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00960  Alkaloid biosynthesis II
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.11
            ExPASy - ENZYME nomenclature database: 1.14.11.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.11
            BRENDA, the Enzyme Database: 1.14.11.11
///
ENTRY       EC 1.14.11.12
NAME        Gibberellin-44 dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     (Gibberellin-44),2-oxoglutarate:oxygen oxidoreductase
REACTION    Gibberellin 44 + 2-Oxoglutarate + O2 = Gibberellin 19 + Succinate +
            CO2
SUBSTRATE   Gibberellin 44
            2-Oxoglutarate
            O2
PRODUCT     Gibberellin 19
            Succinate
            CO2
COFACTOR    Iron
COMMENT     Requires Fe2+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.12
            ExPASy - ENZYME nomenclature database: 1.14.11.12
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.12
            BRENDA, the Enzyme Database: 1.14.11.12
///
ENTRY       EC 1.14.11.13
NAME        Gibberellin 2beta-dioxygenase
            Gibberellin 2beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     (Gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-
            hydroxylating)
REACTION    Gibberellin 1 + 2-Oxoglutarate + O2 = 2beta-Hydroxygibberellin 1 +
            Succinate + CO2
SUBSTRATE   Gibberellin 1
            2-Oxoglutarate
            O2
PRODUCT     2beta-Hydroxygibberellin 1
            Succinate
            CO2
COMMENT     Also acts on a number of other gibberellins.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.13
            ExPASy - ENZYME nomenclature database: 1.14.11.13
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.13
            BRENDA, the Enzyme Database: 1.14.11.13
///
ENTRY       EC 1.14.11.14
NAME        6beta-Hydroxyhyoscyamine epoxidase
            Hydroxyhyoscyamine dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     (6S)-6-Hydroxyhyoscyamine,2-oxoglutarate oxidoreductase
            $ (epoxide-forming)
REACTION    (6S)-6-Hydroxyhyoscyamine + 2-Oxoglutarate + O2 = Scopolamine +
            Succinate + CO2
SUBSTRATE   (6S)-6-Hydroxyhyoscyamine
            2-Oxoglutarate
            O2
PRODUCT     Scopolamine
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
PATHWAY     PATH: MAP00960  Alkaloid biosynthesis II
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.14
            ExPASy - ENZYME nomenclature database: 1.14.11.14
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.14
            BRENDA, the Enzyme Database: 1.14.11.14
///
ENTRY       EC 1.14.11.15
NAME        Gibberellin 3beta-dioxygenase
            Gibberellin 3beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     (Gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-
            hydroxylating)
REACTION    Gibberellin 20 + 2-Oxoglutarate + O2 = Gibberellin 1 + Succinate +
            CO2
SUBSTRATE   Gibberellin 20
            2-Oxoglutarate
            O2
PRODUCT     Gibberellin 1
            Succinate
            CO2
COFACTOR    Iron
            Ascorbate
COMMENT     Requires Fe2+ and ascorbate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.15
            ExPASy - ENZYME nomenclature database: 1.14.11.15
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.15
            BRENDA, the Enzyme Database: 1.14.11.15
///
ENTRY       EC 1.14.11.16
NAME        Peptide-aspartate beta-dioxygenase
            Aspartate beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    Peptide L-aspartate + 2-Oxoglutarate + O2 =
            Peptide 3-hydroxy-L-aspartate + Succinate + CO2
SUBSTRATE   Peptide L-aspartate
            2-Oxoglutarate
            O2
PRODUCT     Peptide 3-hydroxy-L-aspartate
            Succinate
            CO2
COFACTOR    Iron
COMMENT     Requires Fe2+. Some vitamin K-dependent coagulation factors, as
            well as synthetic peptides based on the structure of the first
            epidermal growth factor domain of human coagulation factor IX or
            X, can act as acceptors.
GENES       HSA: 444(ASPH)
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.16
            ExPASy - ENZYME nomenclature database: 1.14.11.16
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.16
            BRENDA, the Enzyme Database: 1.14.11.16
///
ENTRY       EC 1.14.11.17
NAME        Taurine dioxygenase
            2-Aminoethanesulfonate dioxygenase
            alpha-Ketoglutarate-dependent taurine dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With 2-oxoglutarate as one donor, and incorporation of one atom
            each of oxygen into both donors
SYSNAME     Taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)
REACTION    Taurine + 2-Oxoglutarate + O2 = Sulfite + Aminoacetaldehyde +
            Succinate + CO2
SUBSTRATE   Taurine
            2-Oxoglutarate
            O2
PRODUCT     Sulfite
            Aminoacetaldehyde
            Succinate
            CO2
COFACTOR    Fe(II)
COMMENT     Requires Fe(II). The enzyme from E. coli also acts on
            pentanesulfonate, 3-(N-morpholino)propanesulfonate and 2-(1,3-
            dioxoisoindolin-2-yl)ethanesulfonate, but at lower rates.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.11.17
            ExPASy - ENZYME nomenclature database: 1.14.11.17
            WIT (What Is There) Metabolic Reconstruction: 1.14.11.17
///
ENTRY       EC 1.14.12.1
NAME        Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
            Anthranilate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating,
            $ deaminating, decarboxylating)
REACTION    Anthranilate + NADH or NADPH + O2 + 2 H2O = Catechol + CO2 +
            NAD+ or NADP+ + NH3
SUBSTRATE   Anthranilate
            NADH
            NADPH
            O2
            H2O
PRODUCT     Catechol
            CO2
            NAD+
            NADP+
            NH3
COFACTOR    Iron
COMMENT     Requires Fe2+.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00629  Carbazole degradation
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.1
            ExPASy - ENZYME nomenclature database: 1.14.12.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.1
            BRENDA, the Enzyme Database: 1.14.12.1
///
ENTRY       EC 1.14.12.2
NAME        Transferred to EC 1.14.13.35
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
COMMENT     Transferred entry. Now EC 1.14.13.35 - Anthranilate
            3-monooxygenase (deaminating).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.2
            ExPASy - ENZYME nomenclature database: 1.14.12.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.2
///
ENTRY       EC 1.14.12.3
NAME        Benzene 1,2-dioxygenase
            Benzene hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Benzene,NADH:oxygene 1,2-oxidoreductase
REACTION    Benzene + NADH + O2 = cis-1,2-Dihydrobenzene-1,2-diol + NAD+
SUBSTRATE   Benzene
            NADPH
            O2
PRODUCT     cis-1,2-Dihydrobenzene-1,2-diol
            NAD+
COFACTOR    Iron
            Sulfur
            FAD
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin.
            Requires Fe2+.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00626  Nitorobenzene degradation
MOTIF       PS: PS00570  C-x-H-R-[GA]-x(8)-G-N-x(5)-C-x-[FY]-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.3
            ExPASy - ENZYME nomenclature database: 1.14.12.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.3
            BRENDA, the Enzyme Database: 1.14.12.3
///
ENTRY       EC 1.14.12.4
NAME        3-Hydroxy-2-methylpyridinecarboxylate dioxygenase
            Methylhydroxypyridinecarboxylate oxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     3-Hydroxy-2-methylpyridine-5-carboxylate,NAD(P)H:oxygen
            $ oxidoreductase (decyclizing)
REACTION    3-Hydroxy-2-methylpyridine-5-carboxylate + NADH or NADPH + O2 =
            2-(Acetamidomethylene)succinate + NAD+ or NADP+
SUBSTRATE   3-Hydroxy-2-methylpyridine-5-carboxylate
            NADH
            NADPH
            O2
PRODUCT     2-(Acetamidomethylene)succinate
            NAD+
            NADP+
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.4
            ExPASy - ENZYME nomenclature database: 1.14.12.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.4
            BRENDA, the Enzyme Database: 1.14.12.4
///
ENTRY       EC 1.14.12.5
NAME        5-Pyridoxate dioxygenase
            5-Pyridoxate oxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     5-Pyridoxate,NADPH:oxygen oxidoreductase (decyclizing)
REACTION    3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate +
            NADPH + O2 = 2-(Acetamidomethylene)-3-(hydroxymethyl)succinate +
            NADP+
SUBSTRATE   3-Hydroxy-4-hydroxymethyl-2-methylpyridine-5-carboxylate
            NADPH
            O2
PRODUCT     2-(Acetamidomethylene)-3-(hydroxymethyl)succinate
            NADP+
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.5
            ExPASy - ENZYME nomenclature database: 1.14.12.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.5
            BRENDA, the Enzyme Database: 1.14.12.5
///
ENTRY       EC 1.14.12.6
NAME        Transferred to EC 1.14.13.66
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
COMMENT     Transferred entry. Now EC 1.14.13.66 - 2-Hydroxycyclohexanone
            2-monooxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.6
            ExPASy - ENZYME nomenclature database: 1.14.12.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.6
            BRENDA, the Enzyme Database: 1.14.12.6
///
ENTRY       EC 1.14.12.7
NAME        Phthalate 4,5-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)
REACTION    Phthalate + NADH + O2 =
            cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate +
            NAD+ + H2O
SUBSTRATE   Phthalate
            NADH
            O2
PRODUCT     cis-4,5-Dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate
            NAD+
            H2O
COFACTOR    Iron
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FMN), an iron-sulfur oxygenase, and no independent
            ferredoxin. Requires Fe2+.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
            PS: PS00570  C-x-H-R-[GA]-x(8)-G-N-x(5)-C-x-[FY]-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.7
            ExPASy - ENZYME nomenclature database: 1.14.12.7
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.7
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.7
            BRENDA, the Enzyme Database: 1.14.12.7
///
ENTRY       EC 1.14.12.8
NAME        4-Sulfobenzoate 3,4-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     4-Sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating,
            $ sulfite-forming)
REACTION    4-Sulfobenzoate + NADH + O2 = 3,4-Dihydroxybenzoate + Sulfite +
            NAD+
SUBSTRATE   4-Sulfobenzoate
            NADH
            O2
PRODUCT     3,4-Dihydroxybenzoate
            Sulfite
            NAD+
COFACTOR    Iron
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FMN), an iron-sulfur oxygenase, and no independent
            ferredoxin. Requires Fe2+.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.8
            ExPASy - ENZYME nomenclature database: 1.14.12.8
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.8
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.8
            BRENDA, the Enzyme Database: 1.14.12.8
///
ENTRY       EC 1.14.12.9
NAME        4-Chlorophenylacetate 3,4-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     4-Chlorophenylacetate,NADH:oxygen oxidoreductase
            $ (3,4-hydroxylating, dechlorinating)
REACTION    4-Chlorophenyl acetate + NADH + O2 + H2O =
            3,4-Dihydroxyphenyl acetate + Chloride + NAD+
SUBSTRATE   4-Chlorophenyl acetate
            NADH
            O2
            H2O
            4-Bromophenyl acetate
PRODUCT     3,4-Dihydroxyphenyl acetate
            Chloride
            Bromide
            NAD+
COFACTOR    Iron
COMMENT     A system containing a reductase and an iron-sulfur oxygenase, and
            no independent ferredoxin. Requires Fe2+.  Also acts on
            4-bromophenyl acetate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.9
            ExPASy - ENZYME nomenclature database: 1.14.12.9
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.9
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.9
            BRENDA, the Enzyme Database: 1.14.12.9
///
ENTRY       EC 1.14.12.10
NAME        Benzoate 1,2-dioxygenase
            Benzoate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Benzoate,NADH:oxygen oxidoreductase
            (1,2-hydroxylating, decarboxylating)
REACTION    Benzoate + NADH + O2 = Catechol + CO2 + NAD+
SUBSTRATE   Benzoate
            NADH
            O2
PRODUCT     Catechol
            CO2
            NAD+
COFACTOR    Iron
            Sulfur
            FAD
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FAD), and an iron-sulfur oxygenase. Requires Fe2+.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
MOTIF       PS: PS00570  C-x-H-R-[GA]-x(8)-G-N-x(5)-C-x-[FY]-H
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.10
            ExPASy - ENZYME nomenclature database: 1.14.12.10
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.10
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.10
            BRENDA, the Enzyme Database: 1.14.12.10
///
ENTRY       EC 1.14.12.11
NAME        Toluene dioxygenase
            Toluene 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
REACTION    Toluene + NADH + O2 =
            (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+
SUBSTRATE   Toluene
            NADH
            O2
PRODUCT     (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol
            NAD+
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FMN), an iron-sulfur oxygenase, and a ferredoxin.
            Some other aromatic compounds, including ethylbenzene, 4-xylene
            and some halogenated toluenes, are converted into the
            corresponding cis-dihydrodiols.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.11
            ExPASy - ENZYME nomenclature database: 1.14.12.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.11
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.11
            BRENDA, the Enzyme Database: 1.14.12.11
///
ENTRY       EC 1.14.12.12
NAME        Naphthalene 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     Naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)
REACTION    Naphthalene + NADH + O2 =
            (1S,2S)-1,2-Dihydroxynaphthalene-1,2-diol + NAD+;
            Naphthalene + NADH + O2 =
            cis-1,2-Dihydronaphthalene-1,2-diol + NAD+
SUBSTRATE   Naphthalene
            NADH
            O2
PRODUCT     (1S,2S)-1,2-Dihydroxynaphthalene-1,2-diol
            cis-1,2-Dihydronaphthalene-1,2-diol
            NAD+
COFACTOR    Iron
COMMENT     A system, containing a reductase which is an iron-sulfur
            flavoprotein (FAD), an iron-sulfur oxygenase, and ferredoxin.
            Requires Fe2+.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00628  Fluorene degradation
            PATH: MAP00642  Ethylbenzene degradation
MOTIF       PS: PS00570  C-x-H-R-[GA]-x(8)-G-N-x(5)-C-x-[FY]-H
STRUCTURES  PDB: 1NDO  1EG9  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.12
            ExPASy - ENZYME nomenclature database: 1.14.12.12
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.12
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.12
            BRENDA, the Enzyme Database: 1.14.12.12
            SCOP (Structural Classification of Proteins): 1.14.12.12
///
ENTRY       EC 1.14.12.13
NAME        2-Chlorobenzoate 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
SYSNAME     2-Chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating,
            $ dechlorinating, decarboxylating)
REACTION    2-Chlorobenzoate + NADH + O2 = Catechol + Chloride + NAD+
SUBSTRATE   2-Chlorobenzoate
            NADH
            O2
PRODUCT     Catechol
            Chloride
            NAD+
COFACTOR    Iron
COMMENT     A system.  Requires Fe2+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.13
            ExPASy - ENZYME nomenclature database: 1.14.12.13
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.13
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.13
            BRENDA, the Enzyme Database: 1.14.12.13
///
ENTRY       EC 1.14.12.14
NAME        2-Aminobenzenesulfonate 2,3-dioxygenase
            2-Aminosulfobenzene 2,3-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
REACTION    2-Aminobenzenesulfonate + NADH + O2 = 3-Sulfocatechol + NH3 + NAD+
SUBSTRATE   2-Aminobenzenesulfonate
            NADH
            O2
PRODUCT     3-Sulfocatechol
            NH3
            NAD+
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.14
            ExPASy - ENZYME nomenclature database: 1.14.12.14
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.14
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.14
///
ENTRY       EC 1.14.12.15
NAME        Terephthalate 1,2-dioxygenase
            Benzene-1,4-dicarboxylate 1,2-dioxygenase
            1,4-Dicarboxybenzoate 1,2-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
REACTION    Terephthalate + NADH + O2 =
            (1R,6S)-Dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+
SUBSTRATE   Terephthalate
            NADH
            O2
PRODUCT     (1R,6S)-Dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate
            NAD+
COMMENT     In C.testoteroni, contains a Rieske [2Fe-2S] centre.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.15
            ExPASy - ENZYME nomenclature database: 1.14.12.15
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.15
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.15
///
ENTRY       EC 1.14.12.16
NAME        2-Hydroxyquinoline 5,6-dioxygenase
            2-Oxo-1,2-dihydroquinoline 5,6-dioxygenase
            Quinolin-2-ol 5,6-dioxygenase
            Quinolin-2(1H)-one 5,6-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of two atoms
            of oxygen into one donor
REACTION    Quinolin-2-ol + NADH + O2 = 2,5,6-Trihydroxy-5,6-dihydroquinoline +
            NAD+
SUBSTRATE   Quinolin-2-ol
            NADH
            O2
PRODUCT     2,5,6-Trihydroxy-5,6-dihydroquinoline
            NAD+
COMMENT     3-methylquinolin-2-ol, quinolin-8-ol and quinolin-2,8-diol are also
            substrates.
            Quinolin-2-ols exist largely as their quinolin-2(1H)-one tautomers.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.12.16
            ExPASy - ENZYME nomenclature database: 1.14.12.16
            WIT (What Is There) Metabolic Reconstruction: 1.14.12.16
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.12.16
///
ENTRY       EC 1.14.13.1
NAME        Salicylate 1-monooxygenase
            Salicylate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Salicylate,NADH:oxygen oxidoreductase (1-hydroxylating,
            decarboxylating)
REACTION    Salicylate + NADH + O2 = Catechol + NAD+ + H2O + CO2
SUBSTRATE   Salicylate
            NADH
            O2
PRODUCT     Catechol
            NAD+
            H2O
            CO2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00626  Nitorobenzene degradation
GENES       ECE: Z3390
            ECS: ECs3027
            SME: SMc02116
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.1
            ExPASy - ENZYME nomenclature database: 1.14.13.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.1
            BRENDA, the Enzyme Database: 1.14.13.1
///
ENTRY       EC 1.14.13.2
NAME        4-Hydroxybenzoate 3-monooxygenase
            p-Hydroxybenzoate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)
REACTION    4-Hydroxybenzoate + NADPH + O2 = Protocatechuate + NADP+ + H2O
SUBSTRATE   4-Hydroxybenzoate
            NADPH
            O2
PRODUCT     Protocatechuate
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). The enzyme from Pseudomonas is highly
            specific for NADPH (cf. EC 1.14.13.33).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00623  2,4-Dichlorobenzoate degradation
GENES       PAE: PA0247(pobA)
            MLO: mlr7212
            SME: SMb20583(pobA)
            CCR: CC2404
STRUCTURES  PDB: 1BGJ  1BGN  1BKW  1CC4  1CC6  1CJ2  1CJ3  1CJ4  1D7L  1IUS  
                 1IUT  1IUU  1IUV  1IUW  1IUX  1PBB  1PBC  1PBD  1PBE  1PBF  
                 1PDH  1PHH  1PXA  1PXB  1PXC  2PHH  1BF3  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.2
            ExPASy - ENZYME nomenclature database: 1.14.13.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.2
            BRENDA, the Enzyme Database: 1.14.13.2
            SCOP (Structural Classification of Proteins): 1.14.13.2
///
ENTRY       EC 1.14.13.3
NAME        4-Hydroxyphenylacetate 3-monooxygenase
            p-Hydroxyphenylacetate 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxyphenylacetate,NADH:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    4-Hydroxyphenylacetate + NADH + O2 = 3,4-Dihydroxyphenylacetate +
            NAD+ + H2O
SUBSTRATE   4-Hydroxyphenylacetate
            NADH
            O2
PRODUCT     3,4-Dihydroxyphenylacetate
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       ECO: b1007
            ECE: Z1506
            ECS: ECs1253
            YPE: YPO1769(hpaB)
            PMU: PM1522 PM1523
            PAE: PA4091(hpaA) PA4092(hpaC)
            NME: NMB1842
            NMA: NMA0614
            MLO: mlr0087
            BHA: BH3836
            DRA: DRA0223
            AFU: AF0333(hpaA-1) AF0885(hpaA-2) AF1027(hpaA-3)
            SSO: SSO2053(hpaA)
            STO: ST0726
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.3
            ExPASy - ENZYME nomenclature database: 1.14.13.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.3
            BRENDA, the Enzyme Database: 1.14.13.3
///
ENTRY       EC 1.14.13.4
NAME        Melilotate 3-monooxygenase
            2-Hydroxyphenylpropionate hydroxylase
            Melilotate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     3-(2-Hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    3-(2-Hydroxyphenyl)propanoate + NADH + O2 =
            3-(2,3-Dihydroxyphenyl)propanoate + NAD+ + H2O
SUBSTRATE   3-(2-Hydroxyphenyl)propanoate
            NADH
            O2
PRODUCT     3-(2,3-Dihydroxyphenyl)propanoate
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.4
            ExPASy - ENZYME nomenclature database: 1.14.13.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.4
            BRENDA, the Enzyme Database: 1.14.13.4
///
ENTRY       EC 1.14.13.5
NAME        Imidazoleacetate 4-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)
REACTION    Imidazole-4-acetate + NADH + O2 = (5-Hydroxyimidazole)-4-acetate +
            NAD+ + H2O
SUBSTRATE   Imidazole-4-acetate
            NADH
            O2
PRODUCT     (5-Hydroxyimidazole)-4-acetate
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Formerly EC 1.14.1.5.
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.5
            ExPASy - ENZYME nomenclature database: 1.14.13.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.5
            BRENDA, the Enzyme Database: 1.14.13.5
///
ENTRY       EC 1.14.13.6
NAME        Orcinol 2-monooxygenase
            Orcinol hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)
REACTION    Orcinol + NADH + O2 = 2,3,5-Trihydroxytoluene + NAD+ + H2O
SUBSTRATE   Orcinol
            NADH
            O2
PRODUCT     2,3,5-Trihydroxytoluene
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.6
            ExPASy - ENZYME nomenclature database: 1.14.13.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.6
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.6
            BRENDA, the Enzyme Database: 1.14.13.6
///
ENTRY       EC 1.14.13.7
NAME        Phenol 2-monooxygenase
            Phenol hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Phenol,NADPH:oxogen oxidoreductase (2-hydroxylating)
REACTION    Phenol + NADPH + O2 = Catechol + NADP+ + H2O
SUBSTRATE   Phenol
            NADPH
            O2
            Resorcinol
            o-Cresol
PRODUCT     Catechol
            NADP+
            H2O
            Pyrogallol
            2,3-Dihydroxytoluene
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also active with resorcinol and o-cresol.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
            PATH: MAP00626  Nitorobenzene degradation
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
STRUCTURES  PDB: 1FOH  1HQI  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.7
            ExPASy - ENZYME nomenclature database: 1.14.13.7
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.7
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.7
            BRENDA, the Enzyme Database: 1.14.13.7
            SCOP (Structural Classification of Proteins): 1.14.13.7
///
ENTRY       EC 1.14.13.8
NAME        Dimethylaniline monooxygenase (N-oxide-forming)
            Dimethylaniline oxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     N,N-Dimethylaniline,NADPH:oxygen oxidoreductase(N-oxide-forming)
REACTION    N,N-Dimethylaniline + NADPH + O2 = N,N-Dimethylaniline N-oxide +
            NADP+ + H2O
SUBSTRATE   N,N-Dimethylaniline
            NADPH
            O2
            Dialkylarylamine
PRODUCT     N,N-Dimethylaniline N-oxide
            NADP+
            H2O
COFACTOR    Flavin
COMMENT     A flavoprotein. Acts on various dialkylarylamines.
GENES       HSA: 2326(FMO1) 2327(FMO2) 2328(FMO3) 2329(FMO4) 2330(FMO5)
DISEASE     MIM: 136130  Flavin-containing monooxygenase 1, fetal liver
            MIM: 136131  Flavin-containing monooxygenase 2, adult liver
            MIM: 136132  Flavin-containing monooxygenase 3
            MIM: 603955  Flavin-containing monooxygenase 2, pulmonary
            MIM: 603957  Flavin-containing monooxygenase 5
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.8
            ExPASy - ENZYME nomenclature database: 1.14.13.8
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.8
            BRENDA, the Enzyme Database: 1.14.13.8
///
ENTRY       EC 1.14.13.9
NAME        Kynurenine 3-monooxygenase
            Kynurenine 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
REACTION    L-Kynurenine + NADPH + O2 = 3-Hydroxy-L-kynurenine + NADP+ + H2O
SUBSTRATE   L-Kynurenine
            NADPH
            O2
PRODUCT     3-Hydroxy-L-kynurenine
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Formerly EC 1.14.1.2 and 1.99.1.5.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       DME: CG1555
            HSA: 8564(KMO)
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.9
            ExPASy - ENZYME nomenclature database: 1.14.13.9
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.9
            BRENDA, the Enzyme Database: 1.14.13.9
///
ENTRY       EC 1.14.13.10
NAME        2,6-Dihydroxypyridine 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     2,6-Dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)
REACTION    2,6-Dihydroxypyridine + NADH + O2 = 2,3,6-Trihydroxypyridine +
            NAD+ + H2O
SUBSTRATE   2,6-Dihydroxypyridine
            NADH
            O2
PRODUCT     2,3,6-Trihydroxypyridine
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.10
            ExPASy - ENZYME nomenclature database: 1.14.13.10
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.10
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.10
            BRENDA, the Enzyme Database: 1.14.13.10
///
ENTRY       EC 1.14.13.11
NAME        trans-Cinnamate 4-monooxygenase
            Cinnamic acid 4-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     trans-Cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)
REACTION    trans-Cinnamate + NADPH + O2 = trans-4-Hydroxycinnamate + NADP+ + 
            H2O
SUBSTRATE   trans-Cinnamate
            NADPH
            O2
            NADH
PRODUCT     trans-4-Hydroxycinnamate
            NADP+
            H2O
            NAD+
COFACTOR    Heme
COMMENT     NADH also acts, more slowly. Involves a heme-thiolate protein
            (P-450).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       ATH: At2g30490(T6B20.16)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.11
            ExPASy - ENZYME nomenclature database: 1.14.13.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.11
            BRENDA, the Enzyme Database: 1.14.13.11
///
ENTRY       EC 1.14.13.12
NAME        Benzoate 4-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Benzoate,NADPH:oxygen oxidoreductase(4-hydroxylating)
REACTION    Benzoate + NADPH + O2 = 4-Hydroxybenzoate + NADP+ + H2O
SUBSTRATE   Benzoate
            NADPH
            O2
PRODUCT     4-Hydroxybenzoate
            NADP+
            H2O
COFACTOR    Iron
            Tetrahydrobiopterin
COMMENT     Requires Fe2+ and tetrahydrobiopterin.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.12
            ExPASy - ENZYME nomenclature database: 1.14.13.12
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.12
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.12
            BRENDA, the Enzyme Database: 1.14.13.12
///
ENTRY       EC 1.14.13.13
NAME        Calcidiol 1-monooxygenase
            25-Hydroxycholecalciferol 1-hydroxylase
            25-Hydroxycholecalciferol 1-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
REACTION    Calcidiol + NADPH + O2 = Calcitriol + NADP+ + H2O
SUBSTRATE   Calcidiol
            NADPH
            O2
PRODUCT     Calcitriol
            NADP+
            H2O
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.13
            ExPASy - ENZYME nomenclature database: 1.14.13.13
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.13
            BRENDA, the Enzyme Database: 1.14.13.13
///
ENTRY       EC 1.14.13.14
NAME        trans-Cinnamate 2-monooxygenase
            Cinnamic acid 2-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     trans-Cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)
REACTION    trans-Cinnamate + NADPH + O2 = trans-2-Hydroxycinnamate + NADP+ + 
            H2O
SUBSTRATE   trans-Cinnamate
            NADPH
            O2
PRODUCT     trans-2-Hydroxycinnamate
            NADP+
            H2O
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.14
            ExPASy - ENZYME nomenclature database: 1.14.13.14
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.14
            BRENDA, the Enzyme Database: 1.14.13.14
///
ENTRY       EC 1.14.13.15
NAME        Cholestanetriol 26-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen
            $ oxidoreductase (26-hydroxylating)
REACTION    5beta-Cholestane-3alpha,7alpha,12alpha-triol + NADPH + O2 =
            5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol + NADP+ + H2O
SUBSTRATE   5beta-Cholestane-3alpha,7alpha,12alpha-triol
            NADPH
            O2
PRODUCT     5beta-Cholestane-3alpha,7alpha,12alpha,26-tetraol
            NADP+
            H2O
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.15
            ExPASy - ENZYME nomenclature database: 1.14.13.15
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.15
            BRENDA, the Enzyme Database: 1.14.13.15
///
ENTRY       EC 1.14.13.16
NAME        Cyclopentanone monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating,
            $ lactonizing)
REACTION    Cyclopentanone + NADPH + O2 = 5-Valerolactone + NADP+ + H2O
SUBSTRATE   Cyclopentanone
            NADPH
            O2
PRODUCT     5-Valerolactone
            NADP+
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.16
            ExPASy - ENZYME nomenclature database: 1.14.13.16
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.16
            BRENDA, the Enzyme Database: 1.14.13.16
///
ENTRY       EC 1.14.13.17
NAME        Cholesterol 7alpha-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
REACTION    Cholesterol + NADPH + O2 = 7alpha-Hydroxycholesterol + NADP+ + H2O
SUBSTRATE   Cholesterol
            NADPH
            O2
PRODUCT     7alpha-Hydroxycholesterol
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
GENES       HSA: 1581(CYP7A1)
DISEASE     MIM: 118455  Cytochrome P450, subfamily VII (cholesterol
                         7-alpha-monooxygenase),
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.17
            ExPASy - ENZYME nomenclature database: 1.14.13.17
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.17
            BRENDA, the Enzyme Database: 1.14.13.17
///
ENTRY       EC 1.14.13.18
NAME        4-Hydroxyphenylacetate 1-monooxygenase
            4-Hydroxyphenylacetate 1-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase
            $ (1-hydroxylating)
REACTION    4-Hydroxyphenylacetate + NADH or NADPH + O2 = Homogentisate +
            NAD+ or NADP+ + H2O
SUBSTRATE   4-Hydroxyphenylacetate
            NADH
            NADPH
            O2
            4-Hydroxyhydratropate
            4-Hydroxypheoxyacetate
PRODUCT     Homogentisate
            NAD+
            NADP+
            H2O
            2-Methylhomogentisate
            Hydroquinone
            Glycolate
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming
            2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming
            hydroquinone and glycolate).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.18
            ExPASy - ENZYME nomenclature database: 1.14.13.18
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.18
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.18
            BRENDA, the Enzyme Database: 1.14.13.18
///
ENTRY       EC 1.14.13.19
NAME        Taxifolin 8-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating)
REACTION    Taxifolin + NADH or NADPH + O2 = 2,3-Dihydrogossypetin + H2O +
            NAD+ or NADP+
SUBSTRATE   Taxifolin
            NADH
            NADPH
            O2
            Fustin
PRODUCT     2,3-Dihydrogossypetin
            NAD+
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein, converting a flavanol into flavanone. Also acts
            on fustin, but not on catechin, quercitin or mollisacidin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.19
            ExPASy - ENZYME nomenclature database: 1.14.13.19
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.19
            BRENDA, the Enzyme Database: 1.14.13.19
///
ENTRY       EC 1.14.13.20
NAME        2,4-Dichlorophenol 6-monooxygenase
            2,4-Dichlorophenol hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     2,4-Dichlorophenol,NADPH:oxygen oxidoreductase(6-hydroxylating)
REACTION    2,4-Dichlorophenol + NADPH + O2 = 3,5-Dichlorocatechol + NADP+ +
            H2O
SUBSTRATE   2,4-Dichlorophenol
            NADPH
            O2
            4-Chlorophenol
            4-Chloro-2-methylphenol
            NADH
PRODUCT     3,5-Dichlorocatechol
            NADP+
            H2O
            4-Chlorocatechol
            5-Chloro-3-methylcatechol
            NAD+
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Also acts, more slowly, on 4-chlorophenol
            and 4-chloro-2-methylphenol; NADH can act instead of NADPH, but
            more slowly.
PATHWAY     PATH: MAP00627  1,4-Dichlorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.20
            ExPASy - ENZYME nomenclature database: 1.14.13.20
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.20
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.20
            BRENDA, the Enzyme Database: 1.14.13.20
///
ENTRY       EC 1.14.13.21
NAME        Flavonoid 3'-monooxygenase
            Flavonoid 3'-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)
REACTION    a Flavonoid + NADPH + O2 = a 3'-Hydroxyflavonoid + NADP+ + H2O
SUBSTRATE   Flavonoid
            NADPH
            O2
            Naringenin
            Dihydrokaempferol
PRODUCT     3'-Hydroxyflavonoid
            NADP+
            H2O
COMMENT     Acts on a number of flavonoids, including naringenin and
            dihydrokaempferol. Does not act on 4-coumarate or 4-coumaroyl-CoA.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.21
            ExPASy - ENZYME nomenclature database: 1.14.13.21
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.21
            BRENDA, the Enzyme Database: 1.14.13.21
///
ENTRY       EC 1.14.13.22
NAME        Cyclohexanone monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Cyclohexanone,NADPH:oxygen oxidoreductase (6-hydroxylating
            1,2-lactonizing)
REACTION    Cyclohexanone + NADPH + O2 = 6-Hexanolide + NADP+ + H2O
SUBSTRATE   Cyclohexanone
            Cyclic ketone
            NADPH
            O2
PRODUCT     6-Hexanolide
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Acts on a number of other cyclic ketones.
PATHWAY     PATH: MAP00930  Caprolactam degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.22
            ExPASy - ENZYME nomenclature database: 1.14.13.22
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.22
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.22
            BRENDA, the Enzyme Database: 1.14.13.22
///
ENTRY       EC 1.14.13.23
NAME        3-Hydroxybenzoate 4-monooxygenase
            3-Hydroxybenzoate 4-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     3-Hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)
REACTION    3-Hydroxybenzoate + NADPH + O2 = 3,4-Dihydroxybenzoate + NADP+ +
            H2O
SUBSTRATE   3-Hydroxybenzoate
            NADPH
            O2
PRODUCT     3,4-Dihydroxybenzoate
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Acts also on a number of analogues of
            3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.
            Formerly EC 1.14.99.13.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.23
            ExPASy - ENZYME nomenclature database: 1.14.13.23
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.23
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.23
            BRENDA, the Enzyme Database: 1.14.13.23
///
ENTRY       EC 1.14.13.24
NAME        3-Hydroxybenzoate 6-monooxygenase
            3-Hydroxybenzoate 6-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     3-Hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)
REACTION    3-Hydroxybenzoate + NADH + O2 = 2,5-Dihydroxybenzoate + NAD+ + H2O
SUBSTRATE   3-Hydroxybenzoate
            NADH
            O2
PRODUCT     2,5-Dihydroxybenzoate
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). Acts also on a number of analogues of
            3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions;
            NADPH can act instead of NADH, more slowly.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.24
            ExPASy - ENZYME nomenclature database: 1.14.13.24
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.24
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.24
            BRENDA, the Enzyme Database: 1.14.13.24
///
ENTRY       EC 1.14.13.25
NAME        Methane monooxygenase
            Methane hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
REACTION    Methane + NADH + O2 = Methanol + NAD+ + H2O;
            Methane + NADPH + O2 = Methanol + NADP+ + H2O;
            Alkene + NADH + O2 = Epoxide + NAD+ + H2O
SUBSTRATE   Methane
            Alkene
            Aromatic alkane
            Alkane
            NH3
            CO
            NADPH
            NADH
            O2
PRODUCT     Methanol
            Epoxide
            CO2
            NADP+
            NAD+
            H2O
            Hydroxylamine
COFACTOR    Iron
COMMENT     Broad specificity; many alkanes can be hydroxylated, and alkenes
            are converted into the corresponding epoxides; CO is oxidized to
            CO2, ammonia is oxidized to hydroxylamine, and some aromatic
            compounds and cyclic alkanes can also be hydroxylated, more
            slowly. Nonheme diiron enzyme instead of Fe-porphyrin cofactor.
            Consists of three separate protein components; hydroxylase, 
            reductase, and component B.  The hydroxylase component has diiron
            reaction center.  Proposed intermediate Q has a diamond core 
            structure containing two iron (IV) atoms and two oxygen atoms.
PATHWAY     PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
STRUCTURES  PDB: 1FZ1  1FZ2  1FZ3  1FZ4  1FZ5  1FZ0  1FZ7  1FZ8  1FZH  1FZI  
                 1FYZ  1MHZ  1FZ9  1MTY  1FZ6  1MMO  1MHY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.25
            ExPASy - ENZYME nomenclature database: 1.14.13.25
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.25
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.25
            BRENDA, the Enzyme Database: 1.14.13.25
            SCOP (Structural Classification of Proteins): 1.14.13.25
///
ENTRY       EC 1.14.13.26
NAME        Phosphatidylcholine 12-monooxygenase
            Ricinoleic acid synthase
            Oleate delta12-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine:NADH:oxygen
            $ oxidoreductase (12-hydroxylating)
REACTION    1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine + NADH + O2 =
            1-Acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine +
            NAD+ + H2O
SUBSTRATE   1-Acyl-2-oleoyl-sn-glycero-3-phosphocholine
            NADH
            O2
PRODUCT     1-Acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine
            NAD+
            H2O
PATHWAY     PATH: MAP00580  Phospholipid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.26
            ExPASy - ENZYME nomenclature database: 1.14.13.26
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.26
            BRENDA, the Enzyme Database: 1.14.13.26
///
ENTRY       EC 1.14.13.27
NAME        4-Aminobenzoate 1-monooxygenase
            4-Aminobenzoate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating,
            $ decarboxylating)
REACTION    4-Aminobenzoate + NADH or NADPH + O2 = 4-Hydroxyaniline + H2O +
            CO2 + NAD+ or NADP+
SUBSTRATE   4-Aminobenzoate
            NADH
            NADPH
            O2
            Anthranilate
            4-Aminosalicylate
PRODUCT     4-Hydroxyaniline
            NAD+
            NADP+
            H2O
            CO2
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).  Acts on anthranilate and 4-aminosalicylate
            but not on salicylate (cf. EC 1.14.13.1).
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.27
            ExPASy - ENZYME nomenclature database: 1.14.13.27
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.27
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.27
            BRENDA, the Enzyme Database: 1.14.13.27
///
ENTRY       EC 1.14.13.28
NAME        3,9-Dihydroxypterocarpan 6a-monooxygenase
            3,9-Dihydroxypterocarpan 6a-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (6aR,11aR)-3,9-Dihydroxypterocarpan,NADPH:oxygen oxidoreductase
            $ (6a-hydroxylating)
REACTION    (6aR,11aR)-3,9-Dihydroxypterocarpan + NADPH + O2 =
            (6aS,11aS)-3,6a,9-Trihydroxypterocarpan + NADP+ + H2O
SUBSTRATE   (6aR,11aR)-3,9-Dihydroxypterocarpan
            NADPH
            O2
PRODUCT     (6aS,11aS)-3,6a,9-Trihydroxypterocarpan
            NADP+
            H2O
COFACTOR    Heme
COMMENT     Possibly a heme-thiolate protein (P-450).  The product of the
            reaction is the biosynthetic precursor of the phytoalexin
            glyceollin in soybean.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.28
            ExPASy - ENZYME nomenclature database: 1.14.13.28
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.28
            BRENDA, the Enzyme Database: 1.14.13.28
///
ENTRY       EC 1.14.13.29
NAME        4-Nitrophenol 2-monooxygenase
            4-Nitrophenol hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)
REACTION    4-Nitrophenol + NADH + O2 = 4-Nitrocatechol + NAD+ + H2O
SUBSTRATE   4-Nitrophenol
            NADH
            O2
PRODUCT     4-Nitrocatechol
            NAD+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.29
            ExPASy - ENZYME nomenclature database: 1.14.13.29
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.29
            BRENDA, the Enzyme Database: 1.14.13.29
///
ENTRY       EC 1.14.13.30
NAME        Leukotriene-B4 20-monooxygenase
            Leukotriene-B4 20-hydroxylase
            Leukotriene-B4 omega-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-
            $tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
REACTION    (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate + NADPH + O2 =
            (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-
            $tetraenoate + NADP+ + H2O
SUBSTRATE   (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate
            NADPH
            O2
PRODUCT     (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-
            $tetraenoate
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).  Not identical with 1.14.13.34.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: 4051(CYP4F3) 8529(CYP4F2)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.30
            ExPASy - ENZYME nomenclature database: 1.14.13.30
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.30
            BRENDA, the Enzyme Database: 1.14.13.30
///
ENTRY       EC 1.14.13.31
NAME        2-Nitrophenol 2-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     2-Nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating,
            $ nitrite-forming)
REACTION    2-Nitrophenol + NADPH + O2 = Catechol + Nitrite + NADP+ + H2O
SUBSTRATE   2-Nitrophenol
            NADPH
            O2
PRODUCT     Catechol
            Nitrite
            NADP+
            H2O
COMMENT     Involved in the metabolism of nitro-aromatic compounds by a
            strain of Pseudomonas putida.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.31
            ExPASy - ENZYME nomenclature database: 1.14.13.31
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.31
            BRENDA, the Enzyme Database: 1.14.13.31
///
ENTRY       EC 1.14.13.32
NAME        Albendazole monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
REACTION    Albendazole + NADPH + O2 = Albendazole S-oxide + NADP+ + H2O
SUBSTRATE   Albendazole
            NADPH
            O2
PRODUCT     Albendazole S-oxide
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.32
            ExPASy - ENZYME nomenclature database: 1.14.13.32
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.32
            BRENDA, the Enzyme Database: 1.14.13.32
///
ENTRY       EC 1.14.13.33
NAME        4-Hydroxybenzoate 3-monooxygenase (NAD(P)H)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)
REACTION    4-Hydroxybenzoate + NADH or NADPH + O2 = 3,4-Dihydroxybenzoate +
            NAD+ or NADP+ + H2O
SUBSTRATE   4-Hydroxybenzoate
            NADH
            NADPH
            O2
PRODUCT     3,4-Dihydroxybenzoate
            NAD+
            NADP+
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). The enzyme from Corynebacterium
            cyclohexanicum is highly specific for 4-hydroxybenzoate, but uses
            NADH and NADPH at approximately equal rates (cf. EC 1.14.13.2).
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.33
            ExPASy - ENZYME nomenclature database: 1.14.13.33
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.33
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.33
            BRENDA, the Enzyme Database: 1.14.13.33
///
ENTRY       EC 1.14.13.34
NAME        Leukotriene-E4 20-monooxygenase
            Leukotriene-E4 omega-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyicosa-7,9,11,14-
            $tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
REACTION    (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,
            $14-tetraenoate + NADPH + O2 = 20-Hydroxy-leukotriene E4 + NADP+
            + H2O
SUBSTRATE   (7E,9E,11Z,14Z)-(5S,6R)-6-(Cystein-S-yl)-5-hydroxyeicosa-7,9,11,
            $14-tetraenoate
            NADPH
            O2
PRODUCT     20-Hydroxy-leukotriene E4
            NADP+
            H2O
COMMENT     Also acts on N-acetyl-leukotriene E4, more slowly. Not identical
            with EC 1.14.13.30.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.34
            ExPASy - ENZYME nomenclature database: 1.14.13.34
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.34
            BRENDA, the Enzyme Database: 1.14.13.34
///
ENTRY       EC 1.14.13.35
NAME        Anthranilate 3-monooxygenase (deaminating)
            Anthranilate hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating,
            $ deaminating)
REACTION    Anthranilate + NADPH + O2 = 2,3-Dihydroxybenzoate + NADP+ + NH3
SUBSTRATE   Anthranilate
            NADPH
            O2
PRODUCT     2,3-Dihydroxybenzoate
            NADP+
            NH3
COMMENT     The enzyme from Aspergillus niger is an iron protein; that from
            the yeast Trichosporon cutaneum is a flavoprotein (FAD).
            Previously EC 1.14.12.2.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00629  Carbazole degradation
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.35
            ExPASy - ENZYME nomenclature database: 1.14.13.35
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.35
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.35
            BRENDA, the Enzyme Database: 1.14.13.35
///
ENTRY       EC 1.14.13.36
NAME        5-O-(4-Coumaroyl)-D-quinate 3'-monooxygenase
            5-O-(4-Coumaroyl)-D-quinate/shikimate 3'-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     trans-5-O-(4-Coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase
            $ (3'-hydorxylating)
REACTION    trans-5-O-(4-Coumaroyl)-D-quinate + NADPH + O2 =
            trans-5-O-caffeoyl-D-quinate + NADP+ + H2O
SUBSTRATE   trans-5-O-(4-Coumaroyl)-D-quinate
            NADPH
            O2
            trans-5-O-(4-Coumaroyl)shikimate
PRODUCT     trans-5-O-caffeoyl-D-quinate
            NADP+
            H2O
COMMENT     Also acts on trans-5-O-(4-coumaroyl)shikimate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.36
            ExPASy - ENZYME nomenclature database: 1.14.13.36
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.36
            BRENDA, the Enzyme Database: 1.14.13.36
///
ENTRY       EC 1.14.13.37
NAME        Methyltetrahydroprotoberberine 14-monooxygenase
            Methyltetrahydroprotoberberine 14-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (S)-N-Methylcanadine,NADPH:oxygen oxidoreductase
            $ (14-hydroxylating)
REACTION    (S)-N-Methylcanadine + NADPH + O2 = Allocryptopine + NADP+ + H2O
SUBSTRATE   (S)-N-Methylcanadine
            NADPH
            O2
PRODUCT     Allocryptopine
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.37
            ExPASy - ENZYME nomenclature database: 1.14.13.37
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.37
            BRENDA, the Enzyme Database: 1.14.13.37
///
ENTRY       EC 1.14.13.38
NAME        Anhydrotetracycline monooxygenase
            ATC oxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)
REACTION    Anhydrotetracycline + NADPH + O2 = 12-Dehydrotetracycline +
            NADP+ + H2O
SUBSTRATE   Anhydrotetracycline
            NADPH
            O2
PRODUCT     12-Dehydrotetracycline
            NADP+
            H2O
COMMENT     Involved in the biosynthesis of the antibiotics tetracyclines in
            Streptomyces sp.
PATHWAY     PATH: MAP00253  Tetracycline biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.38
            ExPASy - ENZYME nomenclature database: 1.14.13.38
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.38
            BRENDA, the Enzyme Database: 1.14.13.38
///
ENTRY       EC 1.14.13.39
NAME        Nitric-oxide synthase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
REACTION    L-Arginine + n NADPH + m O2 = Citrulline + Nitric oxide + n NADP+
SUBSTRATE   L-Arginine
            NADPH
            O2
PRODUCT     Citrulline
            Nitric oxide
            NADP+
INHIBITOR   Ngamma-Nitro-L-arginine
            Ngamma-Nitro-L-arginine methyl ester
            Ngamma-Monomethyl-L-arginine
COFACTOR    Calcium
COMMENT     The enzyme in brain, but not that induced in lung or liver by
            endotoxin, requires Ca2+. The stoichiometry is not clear, but
            may involve a two-electron and a one-electron oxidation step.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       DME: CG6713(Nos)
            MMU: 97360(Nos1) 97361(Nos2)
            HSA: 4842(NOS1) 4843(NOS2A) 4846(NOS3)
DISEASE     MIM: 163729  Nitric oxide synthase 3, endothelial cell
            MIM: 163730  Nitric oxide synthase 2A, inducible, hepatocytes
            MIM: 163731  Nitric oxide synthase 1, neuronal
STRUCTURES  PDB: 1D1Y  1DD7  1DF1  1DM6  1DM7  1DM8  1DMI  1DMJ  1DMK  1DWV  
                 1DWW  1DWX  1ED4  1ED5  1ED6  1F20  1FOI  1FOL  1FOO  1D1W  
                 1I83  1NOC  1NOD  1NOS  1NSE  1NSI  1QOM  2NOD  2NOS  2NSE  
                 2NSI  3NOD  3NOS  3NSE  1D1V  1D1X  1FOP  4NOS  4NSE  9NSE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.39
            ExPASy - ENZYME nomenclature database: 1.14.13.39
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.39
            BRENDA, the Enzyme Database: 1.14.13.39
            SCOP (Structural Classification of Proteins): 1.14.13.39
///
ENTRY       EC 1.14.13.40
NAME        Anthraniloyl-CoA monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     2-Aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)
REACTION    2-Aminobenzoyl-CoA + 2 NADH or 2 NADPH + O2 =
            2-Amino-5-oxocyclohex-1-enecarbonyl-CoA + H2O + 2 NAD+ or 2 NADP+
SUBSTRATE   2-Aminobenzoyl-CoA
            NADH
            NADPH
            O2
PRODUCT     2-Amino-5-oxocyclohex-1-enecarbonyl-CoA
            H2O
            NAD+
            NADP+
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). The non-aromatic product is unstable and
            releases CO2 and NH3, forming 1,4-cyclohexanedione.
PATHWAY     PATH: MAP00629  Carbazole degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.40
            ExPASy - ENZYME nomenclature database: 1.14.13.40
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.40
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.40
            BRENDA, the Enzyme Database: 1.14.13.40
///
ENTRY       EC 1.14.13.41
NAME        Tyrosine N-monooxygenase
            Tyrosine N-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     L-Tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)
REACTION    L-Tyrosine + NADPH + O2 = N-Hydroxy-L-tyrosine + NADP+ + H2O
SUBSTRATE   L-Tyrosine
            NADPH
            O2
PRODUCT     N-Hydroxy-L-tyrosine
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.41
            ExPASy - ENZYME nomenclature database: 1.14.13.41
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.41
            BRENDA, the Enzyme Database: 1.14.13.41
///
ENTRY       EC 1.14.13.42
NAME        Hydroxyphenylacetonitrile 2-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     4-Hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase
            $ (2-hydroxylating)
REACTION    4-Hydroxyphenylacetonitrile + NADPH + O2 =
            4-Hydroxymandelonitrile + NADP+ + H2O
SUBSTRATE   4-Hydroxyphenylacetonitrile
            NADPH
            O2
PRODUCT     4-Hydroxymandelonitrile
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.42
            ExPASy - ENZYME nomenclature database: 1.14.13.42
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.42
            BRENDA, the Enzyme Database: 1.14.13.42
///
ENTRY       EC 1.14.13.43
NAME        Questin monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Questin,NADPH:oxygen oxidoreductase (hydroxylating,
            $ anthraquinone-ring-opening)
REACTION    Questin + NADPH + O2 = Sulochrin + NADP+ + H2O
SUBSTRATE   Questin
            NADPH
            O2
PRODUCT     Sulochrin
            NADP+
            H2O
COMMENT     The enzyme cleaves the anthraquinone ring of questin to form a
            benzophenone.  Involved in the biosynthesis of the
            seco-anthraquinone (+)-geodin.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.43
            ExPASy - ENZYME nomenclature database: 1.14.13.43
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.43
            BRENDA, the Enzyme Database: 1.14.13.43
///
ENTRY       EC 1.14.13.44
NAME        2-Hydroxybiphenyl 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     2-Hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating)
REACTION    2-Hydroxybiphenyl + NADH + O2 = 2,3-Dihydroxybiphenyl + NAD+ + H2O
SUBSTRATE   2-Hydroxybiphenyl
            NADH
            O2
            2,2'-Dihydroxybiphenyl
PRODUCT     2,3-Dihydroxybiphenyl
            NAD+
            H2O
            2,2',3-Trihydroxybiphenyl
COMMENT     Also converts 2,2'-dihydroxybiphenyl into 2,2',3-trihydroxy-
            biphenyl.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.44
            ExPASy - ENZYME nomenclature database: 1.14.13.44
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.44
            BRENDA, the Enzyme Database: 1.14.13.44
///
ENTRY       EC 1.14.13.45
NAME        CMP-N-acetylneuraminate monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     CMP-N-acetylneuraminate,NAD(P)H:oxygen oxidoreductase
            $ (hydroxylating)
REACTION    CMP-N-acetylneuraminate + NADH or NADPH + O2 =
            CMP-N-glycoloylneuraminate + NAD+ or NADP+ + H2O
SUBSTRATE   CMP-N-acetylneuraminate
            NADH
            NADPH
            O2
PRODUCT     CMP-N-glycoloylneuraminate
            NAD+
            NADP+
            H2O
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.45
            ExPASy - ENZYME nomenclature database: 1.14.13.45
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.45
            BRENDA, the Enzyme Database: 1.14.13.45
///
ENTRY       EC 1.14.13.46
NAME        (-)-Menthol monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (-)-Menthol,NADPH:oxygen oxidoreductase (8-hydroxylating)
REACTION    (-)-Menthol + NADPH + O2 = p-Menthane-3,8-diol + NADP+ + H2O
SUBSTRATE   (-)-Menthol
            NADPH
            O2
PRODUCT     p-Menthane-3,8-diol
            NADP+
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.46
            ExPASy - ENZYME nomenclature database: 1.14.13.46
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.46
            BRENDA, the Enzyme Database: 1.14.13.46
///
ENTRY       EC 1.14.13.47
NAME        (-)-Limonene 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (-)-Limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)
REACTION    (-)-Limonene + NADPH + O2 = (-)-trans-Isopiperitenol + NADP+ + H2O
SUBSTRATE   (-)-Limonene
            NADPH
            O2
PRODUCT     (-)-trans-Isopiperitenol
            NADP+
            H2O
COFACTOR    Heme
COMMENT     High specificity, but NADH can act instead of NADPH, more slowly.
            A heme-thiolate proten (P-450).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.47
            ExPASy - ENZYME nomenclature database: 1.14.13.47
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.47
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.47
            BRENDA, the Enzyme Database: 1.14.13.47
///
ENTRY       EC 1.14.13.48
NAME        (-)-Limonene 6-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (-)-Limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)
REACTION    (-)-Limonene + NADPH + O2 = (-)-trans-Carveol + NADP+ + H2O
SUBSTRATE   (-)-Limonene
            NADPH
            O2
PRODUCT     (-)-trans-Carveol
            NADP+
            H2O
COFACTOR    Heme
COMMENT     High specificity, but NADH can act instead of NADPH, more slowly.
            A heme-thiolate protein (P-450).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.48
            ExPASy - ENZYME nomenclature database: 1.14.13.48
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.48
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.48
            BRENDA, the Enzyme Database: 1.14.13.48
///
ENTRY       EC 1.14.13.49
NAME        (-)-Limonene 7-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     (-)-Limonene,NADPH:oxygen oxidoreductase (7-hydroxylating)
REACTION    (-)-Limonene + NADPH + O2 = (-)-Perillyl alcohol + NADP+ + H2O
SUBSTRATE   (-)-Limonene
            NADPH
            O2
PRODUCT     (-)-Perillyl alcohol
            NADP+
            H2O
COFACTOR    Heme
COMMENT     High specificity, but NADH can act instead of NADPH, more slowly.
            A heme-thiolate protein (P-450).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.49
            ExPASy - ENZYME nomenclature database: 1.14.13.49
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.49
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.49
            BRENDA, the Enzyme Database: 1.14.13.49
///
ENTRY       EC 1.14.13.50
NAME        Pentachlorophenol monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating,
            $ dechloronating)
REACTION    Pentachlorophenol + NADPH + O2 = Tetrachlorohydroquinone +
            NADP+ + Chloride
SUBSTRATE   Pentachlorophenol
            NADPH
            O2
PRODUCT     Tetrachlorohydroquinone
            NADP+
            Chloride
COMMENT     Some tetrachlorophenols and trichlorophenols can act as
            substrates.
PATHWAY     PATH: MAP00627  1,4-Dichlorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.50
            ExPASy - ENZYME nomenclature database: 1.14.13.50
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.50
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.50
            BRENDA, the Enzyme Database: 1.14.13.50
///
ENTRY       EC 1.14.13.51
NAME        6-Oxocineole dehydrogenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     6-Oxocineole,NADPH:oxygen oxidoreductase
REACTION    6-Oxocineole + NADPH + O2 =
            1,6,6-Trimethyl-2,7-dioxobicyclo-[3.2.2]nonan-3-one + NADP+ + H2O
SUBSTRATE   6-Oxocineole
            NADPH
            O2
PRODUCT     1,6,6-Trimethyl-2,7-dioxobicyclo-[3.2.2]nonan-3-one
            NADP+
            H2O
COMMENT     The product undergoes non-enzymic cleavage and subsequent ring
            closure to form the lactone
            4,5-dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-one.
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.51
            ExPASy - ENZYME nomenclature database: 1.14.13.51
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.51
            BRENDA, the Enzyme Database: 1.14.13.51
///
ENTRY       EC 1.14.13.52
NAME        Isoflavone 3'-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)
REACTION    Formononetin + NADPH + O2 = Calycosin + NADP+ + H2O
SUBSTRATE   Formononetin
            NADPH
            O2
PRODUCT     Calycosin
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450). Also acts on biochanin A and
            other isoflavones with a 4'-methoxy group. Involved in the
            biosynthesis of the pterocarpin phytoalexins medicarpin and
            maachiain.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.52
            ExPASy - ENZYME nomenclature database: 1.14.13.52
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.52
            BRENDA, the Enzyme Database: 1.14.13.52
///
ENTRY       EC 1.14.13.53
NAME        Isoflavone 2'-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating)
REACTION    Formononetin + NADPH + O2 = 2'-Hydroxyformononetin + NADP+ + H2O
SUBSTRATE   Formononetin
            NADPH
            O2
PRODUCT     2'-Hydroxyformononetin
            NADP+
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450). Acts on isoflavones with a
            4'-methoxy group. Involved in the biosynthesis of the
            pterocarpin phytoalexins medicarpin and maachiain.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.53
            ExPASy - ENZYME nomenclature database: 1.14.13.53
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.53
            BRENDA, the Enzyme Database: 1.14.13.53
///
ENTRY       EC 1.14.13.54
NAME        Steroid monooxygenase
            Steroid-ketone monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Progesterone + NADPH + O2 = Testosterone acetate + NADP+ + H2O
SUBSTRATE   Progesterone
            NADPH
            O2
            Androstenedione
            17-alpha-Hydroxyprogesterone
PRODUCT     Testosterone acetate
            NADP+
            H2O
            Testolactone
            Androstenedione
            Acetic acid
COMMENT     Also acts on Androst-4-ene-3,17-dione (Androstenedione) to produce
            3-Oxo-13,17-decoandrost-4-eno-17,13-alpha-lactone (Testolactone).
            Also acts on Pregn-4-ene-3,20-dione-17-ol (17-alpha-
            Hydroxyprogesterone) to produce Androst-4-ene-3,17-dione
            (Androstenedione) + Acetic acid.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.54
            ExPASy - ENZYME nomenclature database: 1.14.13.54
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.54
///
ENTRY       EC 1.14.13.55
NAME        Protopine 6-monooxygenase
            Protopine 6-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Protopine + NADPH + O2 = 6-Hydroxyprotopine + NADP+ + H2O
SUBSTRATE   Protopine
            NADPH
            O2
PRODUCT     6-Hydroxyprotopine
            NADP+
            H2O
COMMENT     Involved in Benzophenanthridine alkaloid synthesis in higher plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.55
            ExPASy - ENZYME nomenclature database: 1.14.13.55
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.55
///
ENTRY       EC 1.14.13.56
NAME        Dihydrosanguinarine 10-monooxygenase
            Dihydrosanguinarine 10-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Dihydrosanguinarine + NADPH + O2 = 10-Hydroxydihydrosanguinarine +
            NADP+ + H2O
SUBSTRATE   Dihydrosanguinarine
            NADPH
            O2
PRODUCT     10-Hydroxydihydrosanguinarine
            NADP+
            H2O
COMMENT     Involved in Benzophenanthridine alkaloid synthesis in higher plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.56
            ExPASy - ENZYME nomenclature database: 1.14.13.56
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.56
///
ENTRY       EC 1.14.13.57
NAME        Dihydrochelirubine 12-monooxygenase
            Dihydrochelirubine 12-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Dihydrochelirubine + NADPH + O2 = 12-Hydroxydihydrochelirubine +
            NADP+ + H2O
SUBSTRATE   Dihydrochelirubine
            NADPH
            O2
PRODUCT     12-Hydroxydihydrochelirubine
            NADP+
            H2O
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.57
            ExPASy - ENZYME nomenclature database: 1.14.13.57
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.57
///
ENTRY       EC 1.14.13.58
NAME        Benzoyl-CoA 3-monooxygenase
            Benzoyl-CoA 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Benzoyl-CoA + NADPH + O2 = 3-Hydroxybenzoyl-CoA + NADP+ + H2O
SUBSTRATE   Benzoyl-CoA
            NADPH
            O2
PRODUCT     3-Hydroxybenzoyl-CoA
            NADP+
            H2O
COMMENT     Benzoate is not a substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.58
            ExPASy - ENZYME nomenclature database: 1.14.13.58
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.58
///
ENTRY       EC 1.14.13.59
NAME        L-Lysine 6-monooxygenase (NADPH)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    L-Lysine + NADPH + O2 = N6-Hydroxy-L-lysine + NADP+ + H2O
SUBSTRATE   L-Lysine
            NADPH
            O2
PRODUCT     N6-Hydroxy-L-lysine
            NADP+
            H2O
COMMENT     The enzyme from a strain of E.coli is highly specific for L-Lysine;
            L-Ornithine and L-Homolysine are, for example, not substrates.
            EC 1.13.12.10 catalyses the same reaction, but without the
            involvenent of NADP.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.59
            ExPASy - ENZYME nomenclature database: 1.14.13.59
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.59
///
ENTRY       EC 1.14.13.60
NAME        27-Hydroxycholesterol 7-alpha-monooxygenase
            27-Hydroxycholesterol 7-alpha-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    27-Hydroxycholesterol + NADPH + O2 =
            7-alpha,27-Dihydroxycholesterol + NADP+ + H2O
SUBSTRATE   27-Hydroxycholesterol
            NADPH
            O2
PRODUCT     7-alpha,27-Dihydroxycholesterol
            NADP+
            H2O
COFACTOR    Heme-thiolate(P-450)
COMMENT     The enzyme from mammalian liver differs from cholesterol 7-
            alpha-monooxygenase (EC 1.14.13.17) in having no activity towards
            cholesterol.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.60
            ExPASy - ENZYME nomenclature database: 1.14.13.60
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.60
///
ENTRY       EC 1.14.13.61
NAME        2-Hydroxyquinoline 8-monooxygenase
            2-Oxo-1,2-dihydroquinoline 8-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Quinolin-2-ol + NADH + O2 = Quinolin-2,8-diol + NAD+ + H2O
SUBSTRATE   Quinolin-2-ol
            NADH
            O2
PRODUCT     Quinolin-2,8-diol
            NAD+
            H2O
COFACTOR    Iron
COMMENT     Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.61
            ExPASy - ENZYME nomenclature database: 1.14.13.61
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.61
///
ENTRY       EC 1.14.13.62
NAME        4-Hydroxyquinoline 3-monooxygenase
            Quinolin-4(1H)-one 3-monooxygenase
            1-H-4-Oxoquinoline 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Quinolin-4-ol + NADH + O2 = Quinoline-3,4-diol + NAD+ + H2O
SUBSTRATE   Quinolin-4-ol
            NADH
            O2
PRODUCT     Quinoline-3,4-diol
            NAD+
            H2O
COMMENT     Quinolin-4-ol exists largely as the quinolin-4(1H)-one tautomer.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.62
            ExPASy - ENZYME nomenclature database: 1.14.13.62
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.62
///
ENTRY       EC 1.14.13.63
NAME        3-Hydroxyphenylacetate 6-hydroxylase
            3-Hydroxyphenylacetate 6-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    3-Hydroxyphenylacetate + NADH or NADPH + O2 =
            2,5-Dihydroxyphenylacetate + NAD+ or NADP+ + H2O
SUBSTRATE   3-Hydroxyphenylacetate
            NADH
            NADPH
            O2
PRODUCT     2,5-Dihydroxyphenylacetate
            NAD+
            NADP+
            H2O
COFACTOR    FAD
COMMENT     3-hydroxyphenylacetate 6-hydroxylase from Flavobacterium sp. is
            highly specific for 3-hydroxyphenylacetate and uses NADH and NADPH
            as electron donors with similar efficiency.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.63
            ExPASy - ENZYME nomenclature database: 1.14.13.63
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.63
///
ENTRY       EC 1.14.13.64
NAME        4-Hydroxybenzoate 1-hydroxylase
            4-Hydroxybenzoate 1-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    4-Hydroxybenzoate + NADH or NADPH + O2 = Hydroquinone +
            NAD+ or NADP+ + H2O + CO2
SUBSTRATE   4-Hydroxybenzoate
            NADH
            NADPH
            O2
PRODUCT     Hydroquinone
            NAD+
            NADP+
            H2O
            CO2
COFACTOR    FAD
COMMENT     The enzyme from Candida parapsilosis is specific for
            4-hydroxybenzoate derivatives and prefers NADH to NADPH as
            electron donor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.64
            ExPASy - ENZYME nomenclature database: 1.14.13.64
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.64
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.13.64
///
ENTRY       EC 1.14.13.65
NAME        2-Hydroxyquinoline 8-monooxygenase
            2-Oxo-1,2-dihydroquinoline 5,6-dioxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    Quinolin-2-ol + NADH + O2 = Quinolin-2,8-diol + NAD+;
            3-Methyl-quinolin-2-ol + NADH + O2 = 3-Methyl-quinolin-2,8-diol +
            NAD+
SUBSTRATE   Quinolin-2-ol
            NADH
            O2
            3-Methyl-quinolin-2-ol
PRODUCT     Quinolin-2,8-diol
            NAD+
            3-Methyl-quinolin-2,8-diol
COMMENT     3-methyl-quinolin-2-ol is also a substrate.
            Quinolin-2-ol exists largely as the quinolin-2(1H)-one tautomer.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.65
            ExPASy - ENZYME nomenclature database: 1.14.13.65
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.65
///
ENTRY       EC 1.14.13.66
NAME        2-Hydroxycyclohexanone 2-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With NADH or NADPH as one donor, and incorporation of one atom of
            oxygen
REACTION    2-Hydroxycyclohexan-1-one + NADPH + O2 = 6-Hydroxyhexan-6-olide +
            NADP+ + H2O
SUBSTRATE   2-Hydroxycyclohexan-1-one
            NADPH
            O2
PRODUCT     6-Hydroxyhexan-6-olide
            NADP+
            H2O
COMMENT     The product decomposes spontaneously to 6-oxohexanoic acid (adipic
            semialdehyde).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.13.66
            ExPASy - ENZYME nomenclature database: 1.14.13.66
            WIT (What Is There) Metabolic Reconstruction: 1.14.13.66
///
ENTRY       EC 1.14.14.1
NAME        Unspecific monooxygenase
            Microsomal monooxygenase
            Xenobiotic monooxygenase
            Aryl-4-monooxygenase
            Aryl hydrocarbon hydroxylase
            Microsomal P-450
            Flavoprotein-linked monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced flavin or flavoprotein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Substrate,reduced-flaboprotein:oxygen oxidoreductase
            (RH-hydroxylating or -epoxidizing)
REACTION    RH + Reduced flavoprotein + O2 = ROH + Oxidized flavoprotein
            + H2O
SUBSTRATE   RH
            Steroid
            Fatty acid
            Vitamin
            Prostaglandin
            Reduced flavoprotein
            O2
PRODUCT     ROH
            alpha-Hydroxy fatty acid
            Oxidized flavoprotein
            H2O
COFACTOR    Heme
COMMENT     A group of heme-thiolate proteins (P-450), acting on a wide range
            of substrates including many xenobiotics, steroids, fatty acids,
            vitamins and prostaglandins; reactions catalysed include
            hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-,S-
            and O-dealkylations, desulfation, deamination, and reduction of
            azo, nitro, and N-oxide groups. Together with EC 1.6.2.4 forms a
            system in which two reducing equivalents are supplied by NADPH.
            Formerly EC 1.14.1.1, 1.14.99.8 and 1.99.1.1. Some of the
            reactions attributed to EC 1.14.15.3 belong here.
            (EC 1.6.2.4 NADPH-ferrihemoprotein reductase)
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00380  Tryptophan metabolism
GENES       SME: SMc01812
            BSU: BG12299(yrhJ) BG12871(yetO)
            SCE: YDR402C(DIT2) YHR007C(ERG11)
            SPO: CYP51(cyp51)
            ATH: At1g11680(F25C20.17)
            DME: CG10240 CG10241 CG10246(Cyp6a9) CG10248(Cyp6a8)
                 CG10755(Cyp4e4) CG10842 CG1438(Cyp4c3) CG2060(Cyp4e2) CG2062
                 CG3466(Cyp4d2) CG3540 CG3616(Cyp9c1) CG3656(Cyp4d1)
                 CG3656_1(Cyp4d1) CG3972(Cyp4g1) CG4105(Cyp4e3) CG4321(Cyp4d8)
                 CG4485(Cyp9b1) CG4486(Cyp9b2) CG6816(Cyp18) CG8453(Cyp6-like)
                 CG8864 CG9438(Cyp6a2)
            MMU: 103225(Cyp4b1) 103238(Cyp2c29) 106099(Cyp3a16) 88587(Cyp19)
                 88588(Cyp1a1) 88589(Cyp1a2) 88602(Cyp2d10) 88606(Cyp2d9)
                 88609(Cyp3a11) 88610(Cyp3a13)
            HSA: 11283(CYP4F8) 1543(CYP1A1) 1544(CYP1A2) 1545(CYP1B1)
                 1548(CYP2A6) 1549(CYP2A7) 1551(CYP3A7) 1553(CYP2A13)
                 1554(CYP2B) 1555(CYP2B6) 1557(CYP2C19) 1558(CYP2C8)
                 1559(CYP2C9) 1562(CYP2C18) 1565(CYP2D6) 1571(CYP2E)
                 1572(CYP2F1) 1573(CYP2J2) 1575(CYP3A3) 1576(CYP3A4)
                 1577(CYP3A5) 1580(CYP4B1) 1588(CYP19) 1595(CYP51) 194(AHHR)
DISEASE     MIM: 107910  Cytochrome P450, subfamily XIX (aromatization of
                         androgens)
            MIM: 108330  Cytochrome P450, subfamily I, aromatic
                         compound-inducible,
            MIM: 122720  Cytochrome P450, subfamily IIA,
                         phenobarbital-inducible, polypeptide
            MIM: 124010  Cytochrome P450, subfamily IIIA (nifedipine oxidase)
                         polypeptide 4
            MIM: 124040  Cytochrome P450, subfamily IIE, ethanol-inducible
            MIM: 124060  Cytochrome P450, subfamily I, aromatic
                         compound-inducible,
            MIM: 124070  Cytochrome P450, subfamily IIF, polypeptide 1
            MIM: 124075  Cytochrome P450, subfamily IVB, polypeptide 1
            MIM: 601130  Cytochrome P450, subfamily IIC (mephenytoin
                         4-hydroxylase),
            MIM: 601258  Cytochrome P450, subfamily IIJ (arachidonic acid
                         epoxygenase),
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
STRUCTURES  PDB: 1BU7  1BVY  1DT6  1FAG  2BMH  1FAH  2HPD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.14.1
            ExPASy - ENZYME nomenclature database: 1.14.14.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.14.1
            BRENDA, the Enzyme Database: 1.14.14.1
            SCOP (Structural Classification of Proteins): 1.14.14.1
///
ENTRY       EC 1.14.14.2
NAME        Deleted entry
            Benzopyrene 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced flavin or flavoprotein as one donor, and
            incorporation of one atom of oxygen
COMMENT     Deleted entry. Now included with EC 1.14.14.1.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.14.2
            ExPASy - ENZYME nomenclature database: 1.14.14.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.14.2
///
ENTRY       EC 1.14.14.3
NAME        Alkanal monooxygenase (FMN-linked)
            Aldehyde monooxygenase
            Bacterial luciferase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced flavin or flavoprotein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Alkanal, reduced-FMN:oxygen oxidoreductase (1-hydroxylating,
            luminescing).
REACTION    RCHO + Reduced FMN + O2 = RCOOH + FMN + H2O + hv
SUBSTRATE   RCHO
            Reduced FMN
            O2
PRODUCT     RCOOH
            FMN
            H2O
            hv
COMMENT     The rection sequence involves incorporation of a molecule of
            oxygen into reduced FMN, and subsequent reaction with the
            aldehyde to form an activated FMN. H2O complex which breaks
            down with emission of light. The enzyme is highly specific
            for reduced FMN, and for long-chain aliphatic aldehydes with
            8 carbons or more.
MOTIF       PS: PS00494  [GA]-[LIVM]-P-[LIVM]-x-[LIVMFY]-x-W-x(6)-[RK]-x(6)-Y-
                         x(3)-[AR]
STRUCTURES  PDB: 1BRL  1BSL  1LUC  1XKJ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.14.3
            ExPASy - ENZYME nomenclature database: 1.14.14.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.14.3
            BRENDA, the Enzyme Database: 1.14.14.3
            SCOP (Structural Classification of Proteins): 1.14.14.3
///
ENTRY       EC 1.14.15.1
NAME        Camphor 5-monooxygenase
            Camphor 5-exo-methylene hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     (+)-Camphor,reduced-putidaredoxin:oxygen oxidoreductase
            (5-hydroxylating)
REACTION    (+)-Camphor + Putidaredoxin + O2 = (+)-exo-5-Hydroxycamphor +
            Oxidized putidaredoxin + H2O
SUBSTRATE   (+)-Camphor
            Putidaredoxin
            O2
            (-)-Camphor
            1,2-Campholide
PRODUCT     (+)-exo-5-Hydroxycamphor
            Oxidized putidaredoxin
            H2O
            5-exo-Hydroxy-1,2-campholide
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450)
            Also acts on (-)-camphor and 1,2-campholide, forming
            5-exo-hydroxy-1,2-campholide.
            #STRUCTURE:
            Helcies E(149-156), F(176-185), G(192-205), and I(234-267) form an
            antiparallel Greek key helical bundle.
            Heme: the heme is embedded between the proximal (helix L) and
            distal (helix I) helicies. The heme propionates interact with
            Arg112, Arg299, and His355. Gly249 is close approach to the distal
            heme surface. Gly249 is conxerved among other P-450.
            Axial heme ligand: Cys357 of the N-terminal end of helix L binds
            to Fe(III) in the high-spin state. Phe350, Leu358, and Gln360 form
            a pocket for Cys357.
            Camphor: The carbonyl oxygen form hydrogen bonding to Tyr96 and
            makes hydrophobic contact with Phe87, Leu244, Val247, Thr252,
            Val295. Tyr96 is unique to P-450cam.
            (Poulos et al. J.Biol.Chem., 260, 16122-16130, 1985)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
STRUCTURES  PDB: 4CP4  3CPP  3CP4  2CPP  2CP4  1QMQ  8CPP  1PHF  1PHE  6CP4  
                 6CPP  1PHD  1PHA  1NOO  1GJM  1GEM  1GEK  1GEB  1CP4  1C8J  
                 1AKD  4CPP  5CP4  5CPP  7CPP  1PHC  1PHG  1PHB  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.1
            ExPASy - ENZYME nomenclature database: 1.14.15.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.15.1
            BRENDA, the Enzyme Database: 1.14.15.1
            SCOP (Structural Classification of Proteins): 1.14.15.1
///
ENTRY       EC 1.14.15.2
NAME        Camphor 1,2-monooxygenase
            2,5-Diketocamphane lactonizing enzyme
            Camphor ketolactonase I
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     (+)-Camphor,reduced-rubredoxin:oxygen oxidoreductase
            $ (1,2-lactonizing)
REACTION    (+)-Bornane-2,5-dione + Reduced rubredoxin + O2 =
            5-Oxo-1,2-campholide + Oxidized rubredoxin + H2O
SUBSTRATE   (+)-Bornane-2,5-dione
            Reduced rubredoxin
            O2
PRODUCT     5-Oxo-1,2-campholide
            Oxidozed rubredoxin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.2
            ExPASy - ENZYME nomenclature database: 1.14.15.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.15.2
            BRENDA, the Enzyme Database: 1.14.15.2
///
ENTRY       EC 1.14.15.3
NAME        Alkane 1-monooxygenase
            Alkane 1-hydroxylase
            omega-Hydroxylase
            Fatty acid omega-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Alkane,reduced-rubredoxin:oxygen 1-oxidoreductase
REACTION    Octane + Reduced rubredoxin + O2 = 1-Octanol +
            Oxidized rubredoxin + H2O
SUBSTRATE   Octane
            Reduced rubredoxin
            O2
            Fatty acid
PRODUCT     1-Octanol
            Oxidized rubredoxin
            H2O
            omega-Hydroxy fatty acid
COFACTOR    Heme
COMMENT     Some enzymes in this group are heme-thiolate proteins (P-450).
            Also hydroxylates fatty acids in the omega-position.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       HSA: 1579(CYP4A11)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.3
            ExPASy - ENZYME nomenclature database: 1.14.15.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.3
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.15.3
            BRENDA, the Enzyme Database: 1.14.15.3
///
ENTRY       EC 1.14.15.4
NAME        Steroid 11beta-monooxygenase
            Steroid 11beta-hydroxylase
            Steroid 11beta/18-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase
            (11-hydroxylating)
REACTION    a Steroid + Reduced adrenal ferredoxin + O2 =
            an 11beta-Hydroxysteroid + Oxidized adrenal ferredoxin + H2O
SUBSTRATE   Steroid
            Reduced adrenal ferredoxin
            O2
            18-Hydroxycorticosterone
PRODUCT     11beta-Hydroxysteroid
            Oxidized adrenal ferredoxin
            H2O
            Aldosterone
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450). Also hydroxylates steroids at
            the 18-position, and converts 18-hydroxycorticosterone into
            aldosterone. Formerly EC 1.14.1.6 and 1.99.1.7.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
GENES       HSA: 1584(CYP11B1) 1585(CYP11B2)
DISEASE     MIM: 124080  Cytochrome P450, subfamily XIB, polypeptide 2
            MIM: 202010  Cytochrome P450, subfamily XIB, polypeptide 1
                         (11-beta-hydroxylase;
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.4
            ExPASy - ENZYME nomenclature database: 1.14.15.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.4
            BRENDA, the Enzyme Database: 1.14.15.4
///
ENTRY       EC 1.14.15.5
NAME        Corticosterone 18-monooxygenase
            Corticosterone 18-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase
            $ (18-hydroxylating)
REACTION    Corticosterone + Reduced adrenal ferredoxin + O2 =
            18-Hydroxycorticosterone + Oxidized adrenal ferredoxin + H2O
SUBSTRATE   Corticosterone
            Reduced adrenal ferredoxin
            O2
PRODUCT     18-Hydroxycorticosterone
            Oxidized adrenal ferredoxin
            H2O
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.5
            ExPASy - ENZYME nomenclature database: 1.14.15.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.5
            BRENDA, the Enzyme Database: 1.14.15.5
///
ENTRY       EC 1.14.15.6
NAME        Cholesterol monooxygenase (side-chain-cleaving)
            Cholesterol desmolase
            Cytochrome P-450SCC
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With a reduced iron-sulfur protein as one donor, and
            incorporation of one atom of oxygen
SYSNAME     Cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase
            (side-chain-cleaving)
REACTION    Cholesterol + Reduced adrenal ferredoxin + O2 = Pregnenolone +
            4-Methylpentanal + Oxidized adrenal ferredoxin + H2O
SUBSTRATE   Cholesterol
            Reduced adrenal ferredoxin
            O2
PRODUCT     Pregnenolone
            4-Methylpentanal
            Oxidized adrenal ferredoxin
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein. The reaction proceeds in three stages,
            with hydroxylation at C-20 and C-22 preceding scission of the
            side-chain at C-20.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
GENES       HSA: 1583(CYP11A)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
STRUCTURES  PDB: 1SCC  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.15.6
            ExPASy - ENZYME nomenclature database: 1.14.15.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.15.6
            BRENDA, the Enzyme Database: 1.14.15.6
            SCOP (Structural Classification of Proteins): 1.14.15.6
///
ENTRY       EC 1.14.16.1
NAME        Phenylalanine 4-monooxygenase
            Phenylalaninase
            Phenylalanine 4-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase
            (4-hydroxylating)
REACTION    L-Phenylalanine + Tetrahydrobiopterin + O2 = L-Tyrosine +
            Dihydrobiopterin + H2O
SUBSTRATE   L-Phenylalanine
            Tetrahydrobiopterin
            O2
PRODUCT     L-Tyrosine
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     The mammalian enzyme is an iron protein.  Formerly EC 1.14.3.1
            and 1.99.1.2.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       VCH: VCA0828
            PAE: PA0872(phhA)
            MLO: mlr4831
            CCR: CC1612
            CEL: K08F8.4
            DME: CG7399
            MMU: 97473(Pah)
            HSA: 5053(PAH)
DISEASE     MIM: 261600  Phenylalanine hydroxylase
MOTIF       PS: PS00367  P-D-x(2)-H-[DE]-[LI]-[LIVMF]-G-H-[LIVMC]-P
STRUCTURES  PDB: 4PAH  1PAH  1PHZ  5PAH  6PAH  2PAH  2PHM  3PAH  1DMW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.1
            ExPASy - ENZYME nomenclature database: 1.14.16.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.1
            BRENDA, the Enzyme Database: 1.14.16.1
            SCOP (Structural Classification of Proteins): 1.14.16.1
///
ENTRY       EC 1.14.16.2
NAME        Tyrosine 3-monooxygenase
            Tyrosine 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase
            (3-hydroxylating)
REACTION    L-Tyrosine + Tetrahydrobiopterin + O2 =
            3,4-Dihydroxy-L-phenylalanine + Dihydrobiopterin + H2O
SUBSTRATE   L-Tyrosine
            Tetrahydrobiopterin
            O2
PRODUCT     3,4-Dihydroxy-L-phenylalanine
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+. Activated by phosphorylation, catalysed by
            EC 2.7.1.128.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       CEL: B0432.5
            DME: CG10118(ple)
            MMU: 98735
            HSA: 7054
DISEASE     MIM: 191290  Tyrosine hydroxylase
MOTIF       PS: PS00367  P-D-x(2)-H-[DE]-[LI]-[LIVMF]-G-H-[LIVMC]-P
STRUCTURES  PDB: 1TOH  2TOH  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.2
            ExPASy - ENZYME nomenclature database: 1.14.16.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.2
            BRENDA, the Enzyme Database: 1.14.16.2
            SCOP (Structural Classification of Proteins): 1.14.16.2
///
ENTRY       EC 1.14.16.3
NAME        Anthranilate 3-monooxygenase
            Anthranilate 3-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     Anthranilate,tetrahydrobiopterin:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    Anthranilate + Tetrahydrobiopterin + O2 = 3-Hydroxyanthranilate +
            Dihydrobiopterin + H2O
SUBSTRATE   Anthranilate
            Tetrahydrobiopterin
            O2
PRODUCT     3-Hydroxyanthranilate
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.3
            ExPASy - ENZYME nomenclature database: 1.14.16.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.3
            BRENDA, the Enzyme Database: 1.14.16.3
///
ENTRY       EC 1.14.16.4
NAME        Tryptophan 5-monooxygenase
            Tryptophan 5-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase
            (5-hydroxylating)
REACTION    L-Tryptophan + Tetrahydrobiopterin + O2 =
            5-Hydroxy-L-tryptophan + Dihydrobiopterin + H2O
SUBSTRATE   L-Tryptophan
            Tetrahydrobiopterin
            O2
PRODUCT     5-Hydroxy-L-tryptophan
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+. Activated by phosphorylation, catalysed by a
            Ca2+-activated protein kinase.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       CPN: CPn1046
            CPJ: CPj1046
            DME: CG7399
            MMU: 98796(Tph)
            HSA: 7166(TPH)
DISEASE     MIM: 191060  Tryptophan hydroxylase (tryptophan-5-monooxygenase)
MOTIF       PS: PS00367  P-D-x(2)-H-[DE]-[LI]-[LIVMF]-G-H-[LIVMC]-P
STRUCTURES  PDB: 1IN9  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.4
            ExPASy - ENZYME nomenclature database: 1.14.16.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.4
            BRENDA, the Enzyme Database: 1.14.16.4
///
ENTRY       EC 1.14.16.5
NAME        Glyceryl-ether monooxygenase
            Glyceryl-ether cleaving enzyme
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     1-Alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase
REACTION    1-Alkyl-sn-glycerol + Tetrahydrobiopterin + O2 =
            1-Hydroxyalkyl-sn-glycerol + Dihydrobiopterin + H2O
SUBSTRATE   1-Alkyl-sn-glycerol
            Tetrahydrobiopterin
            O2
PRODUCT     1-Hydroxyalkyl-sn-glycerol
            Dihydrobiopterin
            H2O
COFACTOR    Glutathione
            Phospholipid
COMMENT     Requires reduced glutathione and phospholipids for full activity.
            The product spontaneously breaks down to form a fatty aldehyde
            and glycerol.  Formerly EC 1.14.99.17.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.5
            ExPASy - ENZYME nomenclature database: 1.14.16.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.5
            BRENDA, the Enzyme Database: 1.14.16.5
///
ENTRY       EC 1.14.16.6
NAME        Mandelate 4-monooxygenase
            L-Mandelate 4-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With reduced pteridine as one donor, and incorporation of
            one atom of oxygen
SYSNAME     (S)-2-Hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen
            $ oxidoreductase (4-hydroxylating)
REACTION    (S)-2-Hydroxy-2-phenylacetate + Tetrahydrobiopterin + O2 =
            (S)-4-Hydroxymandelate + Dihydrobiopterin + H2O
SUBSTRATE   (S)-2-Hydroxy-2-phenylacetate
            Tetrahydrobiopterin
            O2
PRODUCT     (S)-4-Hydroxymandelate
            Dihydrobiopterin
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.16.6
            ExPASy - ENZYME nomenclature database: 1.14.16.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.16.6
            BRENDA, the Enzyme Database: 1.14.16.6
///
ENTRY       EC 1.14.17.1
NAME        Dopamine beta-monooxygenase
            Dopamine beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With ascorbate as one donor, and incorporation of one atom of
            oxygen
SYSNAME     3,4-Dihydroxyphenetylamine,ascorbate:oxygen oxidoreductase
            (beta-hydroxylating)
REACTION    3,4-Dihydroxyphenethylamine + Ascorbate + O2 = Noradrenaline +
            Dehydroascorbate + H2O
SUBSTRATE   3,4-Dihydroxyphenethylamine
            Ascorbate
            O2
PRODUCT     Noradrenaline
            Dehydroascorbate
            H2O
COFACTOR    Fumarate
            Copper
            PQQ
COMMENT     A copper protein. Stimulated by fumarate.  Formerly EC 1.14.2.1.
            PQQ: van der Meer,R.A., Jongejan,J.A., Duine,J.A. FEBS Lett. 231,
            303-307 (1988).
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       CEL: H13N06.6
            DME: CG1543(Tbh)
            MMU: 94864(Dbh)
            HSA: 1621(DBH)
DISEASE     MIM: 223360  Dopamine-beta-hydroxylase
MOTIF       PS: PS00084  H-H-M-x(2)-F-x-C
            PS: PS00085  H-x-F-x(4)-H-T-H-x(2)-G
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.17.1
            ExPASy - ENZYME nomenclature database: 1.14.17.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.17.1
            BRENDA, the Enzyme Database: 1.14.17.1
///
ENTRY       EC 1.14.17.2
NAME        Deleted entry
            4-Coumarate 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With ascorbate as one donor, and incorporation of one atom of
            oxygen
COMMENT     Deleted entry. Now included with EC 1.14.18.1 - Monophenol
            monooxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.17.2
            ExPASy - ENZYME nomenclature database: 1.14.17.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.17.2
///
ENTRY       EC 1.14.17.3
NAME        Peptidylglycine monooxygenase
            Peptidylglycine 2-hydroxylase
            Peptidyl alpha-amidating enzyme
            Peptidyl alpha-amide synthetase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With ascorbate as one donor, and incorporation of one atom of
            oxygen
SYSNAME     Peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)
REACTION    Peptidylglycine + Ascorbate + O2 = Peptidyl(2-hydroxyglycine) +
            Dehydroascorbate + H2O
SUBSTRATE   Peptidylglycine
            Ascorbate
            O2
PRODUCT     Peptidyl(2-hydroxyglycine)
            Dehydroascorbate
            H2O
COFACTOR    Copper
COMMENT     A copper protein. Peptidylglycines with a neutral amino acid
            residue in the penultimate position are the best substrates
            for  the enzyme. The product is unstable and dismutates to
            glyoxylate and the corresponding desglycine peptide amide,
            a reaction catalyzed by EC 4.3.2.5.
            Involved in the final step of biosynthesis of alpha-melanotropin
            and related biologically active peptides.
GENES       DME: CG3832(Phm) CG3832_1(Phm)
            HSA: 5066(PAM)
DISEASE     MIM: 170270  Peptidylglycine alpha-amidating monooxygenase
MOTIF       PS: PS00084  H-H-M-x(2)-F-x-C
            PS: PS00085  H-x-F-x(4)-H-T-H-x(2)-G
STRUCTURES  PDB: 1OPM  1PHM  3PHM  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.17.3
            ExPASy - ENZYME nomenclature database: 1.14.17.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.17.3
            BRENDA, the Enzyme Database: 1.14.17.3
            SCOP (Structural Classification of Proteins): 1.14.17.3
///
ENTRY       EC 1.14.18.1
NAME        Monophenol monooxygenase
            Tyrosinase
            Phenolase
            Monophenol oxidase
            Cresolase
SYSNAME     Monophenol,L-dopa:oxygen oxidoreductase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            With another compound as one donor, and incorporation of one atom
            of oxygen
REACTION    L-Tyrosine + L-Dopa + O2 = L-Dopa + Dopaquinone + H2O
SUBSTRATE   L-Tyrosine
            L-Dopa
            Benzenediol
            O2
PRODUCT     L-Dopa
            Dopaquinone
            H2O
COFACTOR    Copper
COMMENT     A group of copper proteins that also catalyse the reaction of
            EC 1.10.3.1, if only benzenediols are available as substrate.
            (EC 1.10.3.1 Catechol oxidase)
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00740  Riboflavin metabolism
            PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       DME: CG5779
            MMU: 94856 98880(Tyr)
            HSA: 7299(TYR)
DISEASE     MIM: 203100  Tyrosinase
MOTIF       PS: PS00497  H-x(4,5)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LVM]-x(3)-E
            PS: PS00498  D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.18.1
            ExPASy - ENZYME nomenclature database: 1.14.18.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.18.1
            BRENDA, the Enzyme Database: 1.14.18.1
///
ENTRY       EC 1.14.99.1
NAME        Prostaglandin-endoperoxide synthase
            Prostaglandin synthase
            Prostaglandin G/H synthase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen
            oxidoreductase
REACTION    Arachidonate + AH2 + 2 O2 = Prostaglandin H2 + A + H2O
SUBSTRATE   Arachidonate
            AH2
            O2
PRODUCT     Prostaglandin H2
            A
            H2O
INHIBITOR   Aspirin
            Ibuprofen
            Diflunisal
            Diclofenac
            Fenprofen calcium
            Indomethacin
            Ketoprofen
            Meclofenamate sodium
            Mefenamic acid
            Naproxen
            Piroxicam
            Sulindac
            Tolmetin sodium
COMMENT     This enzyme acts both as a dioxygenase and as a peroxidase.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 97797(Ptgs1) 97798(Ptgs2)
            HSA: 5742(PTGS1) 5743(PTGS2)
DISEASE     MIM: 176805  Prostaglandin-endoperoxide synthase 1 (prostaglandin
                         G/H synthase and
            MIM: 600262  Prostaglandin-endoperoxide synthase 2 (prostaglandin
                         G/H synthase and
MOTIF       PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
STRUCTURES  PDB: 1CQE  1CVU  1DCX  1DD0  1DDX  1DIY  1DJJ  1EBV  1EQG  1EQH  
                 1HT5  1HT8  1PGE  1PGF  1PGG  1PTH  3PGH  4COX  5COX  6COX  
                 1CX2  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.1
            ExPASy - ENZYME nomenclature database: 1.14.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.1
            BRENDA, the Enzyme Database: 1.14.99.1
            SCOP (Structural Classification of Proteins): 1.14.99.1
///
ENTRY       EC 1.14.99.2
NAME        Kynurenine 7,8-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)
REACTION    Kynurenate + AH2 + O2 = 7,8-Dihydro-7,8-dihydroxykynurenate + A
SUBSTRATE   Kynurenate
            AH2
            O2
PRODUCT     7,8-Dihydro-7,8-dihydroxykynurenate
            A
COMMENT     Formerly Ec 1.14.1.4.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.2
            ExPASy - ENZYME nomenclature database: 1.14.99.2
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.2
            BRENDA, the Enzyme Database: 1.14.99.2
///
ENTRY       EC 1.14.99.3
NAME        Heme oxygenase (decyclizing)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Heme, hydrogen-donor:oxygen oxidoreductase (alpha-methylene-
            oxydizing, hydroxylating)
REACTION    Heme + 3 AH2 + 3 O2 = Biliverdin + Fe2+ + CO + 3 A + 3 H2O
SUBSTRATE   Heme
            AH2
            O2
PRODUCT     Biliverdin
            Fe2+
            CO
            A
            H2O
INHIBITOR   Zinc protoporphyrin-9
COFACTOR    NADH
            NADPH
COMMENT     Requires NAD(P)H and EC 1.6.2.4.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       SYN: sll1184(ho1) sll1875
            AAE: aq_153(ctaA)
            MMU: 96163(Hmox1)
            HSA: 3162(HMOX1) 3163(HMOX2)
DISEASE     MIM: 141250  Heme oxygenase, decycling, 1
            MIM: 141251  Heme oxygenase, decycling, 2
MOTIF       PS: PS00593  L-[IV]-A-H-[STACH]-Y-[STV]-[RT]-Y-[LIVM]-G
STRUCTURES  PDB: 1DVG  1J77  1QQ8  1DVE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.3
            ExPASy - ENZYME nomenclature database: 1.14.99.3
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.3
            BRENDA, the Enzyme Database: 1.14.99.3
            SCOP (Structural Classification of Proteins): 1.14.99.3
///
ENTRY       EC 1.14.99.4
NAME        Progesterone monooxygenase
            Progesterone hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Progesterone,hydrogen-donor:oxygen oxidoreductase
            (hydroxylating)
REACTION    Progesterone + AH2 + O2 = Testosterone acetate + A + H2O
SUBSTRATE   Progesterone
            AH2
            O2
PRODUCT     Testosterone acetate
            A
            H2O
COMMENT     Has a wide specificity.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.4
            ExPASy - ENZYME nomenclature database: 1.14.99.4
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.4
            BRENDA, the Enzyme Database: 1.14.99.4
///
ENTRY       EC 1.14.99.5
NAME        Stearoyl-CoA desaturase
            Acyl-CoA desaturase
            Fatty acid desaturase
            delta9-Desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroyl-CoA,hydrogen-donor:oxygen oxidoreductase
REACTION    Stearoyl-CoA + AH2 + O2 = Oleoyl-CoA + A + 2 H2O
SUBSTRATE   Stearoyl-CoA
            AH2
            O2
PRODUCT     Oleoyl-CoA
            A
            H2O
COFACTOR    Iron
COMMENT     Nonheme diiron enzyme. The rat liver enzyme is an enzyme system
            involving cytochrome b5 and EC 1.6.2.2.
GENES       SYN: sll0541(des9)
            SCE: YGL055W(OLE1)
            CEL: F10D2.9 W06D12.3
            DME: CG5887_1(Fad)
            HSA: 6319(SCD)
MOTIF       PS: PS00476  G-E-x-[FY]-H-N-[FY]-H-H-x-F-P-x-D-Y
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.5
            ExPASy - ENZYME nomenclature database: 1.14.99.5
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.5
            BRENDA, the Enzyme Database: 1.14.99.5
///
ENTRY       EC 1.14.99.6
NAME        Acyl-[acyl-carrier-protein] desaturase
            Stearyl-ACP desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Acyl-[acyl-carrier-protein],hydrogen-donor:oxygen oxidoreductase
REACTION    Stearoyl-[acyl-carrier protein] + AH2 + O2 =
            Oleoyl-[acyl-carrier protein] + A + 2 H2O
SUBSTRATE   Stearoyl-[acyl-carrier protein]
            AH2
            O2
            Stearoyl-CoA
PRODUCT     Oleoyl-[acyl-carrier protein]
            A
            H2O
            Oleoyl-CoA
COFACTOR    Ferredoxin
COMMENT     The enzyme from safflower is specific for stearoyl-CoA; that
            from Euglena acts on derivatives of a number of long-chain fatty
            acids. Requires ferredoxin.
MOTIF       PS: PS00574  [ST]-[SA]-x(3)-[QR]-[LI]-x(5,6)-D-Y-x(2)-[LIVMFYW]-
                         [LIVM]-[DE]
STRUCTURES  PDB: 1AFR  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.6
            ExPASy - ENZYME nomenclature database: 1.14.99.6
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.6
            BRENDA, the Enzyme Database: 1.14.99.6
            SCOP (Structural Classification of Proteins): 1.14.99.6
///
ENTRY       EC 1.14.99.7
NAME        Squalene monooxygenase
            Squalene epoxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)
REACTION    Squalene + AH2 + O2 = (S)-Squalene-2,3-epoxide + A + H2O
SUBSTRATE   Squalene
            AH2
            O2
PRODUCT     (S)-Squalene-2,3-epoxide
            A
            H2O
COFACTOR    FAD
COMMENT     A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7,
            was formerly known as squalene oxydocyclase.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       SCE: YGR175C(ERG1)
            ATH: At2g22830(T20K9.4) At4g37760(T28I19.40)
            HSA: 6713(SQLE)
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.7
            ExPASy - ENZYME nomenclature database: 1.14.99.7
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.7
            BRENDA, the Enzyme Database: 1.14.99.7
///
ENTRY       EC 1.14.99.8
NAME        Deleted entry
            Arene monooxygenase (epoxidizing)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
COMMENT     Deleted entry. Now included with EC 1.14.14.1.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.8
            ExPASy - ENZYME nomenclature database: 1.14.99.8
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.8
///
ENTRY       EC 1.14.99.9
NAME        Steroid 17alpha-monooxygenase
            Steroid 17alpha-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroid,hydrogen-donor:oxygen oxidoreductase
            (17-alpha-hydroxylating)
REACTION    Steroid + AH2 + O2 = 17-alpha-Hydroxysteroid + A + H2O
SUBSTRATE   Steroid
            AH2
            O2
PRODUCT     17-alpha-Hydroxysteroid
            A
            H2O
COFACTOR    NADPH
            NADH
            Heme
COMMENT     Requires NAD(P)H and P-450. Formarly EC 1.14.1.7 and 1.99.1.9.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
GENES       HSA: 1586(CYP17)
DISEASE     MIM: 202110  Cytochrome P450, subfamily XVII (steroid
                         17-alpha-hydroxylase)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
STRUCTURES  PDB: 2C17  
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.9
            ExPASy - ENZYME nomenclature database: 1.14.99.9
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.9
            BRENDA, the Enzyme Database: 1.14.99.9
            SCOP (Structural Classification of Proteins): 1.14.99.9
///
ENTRY       EC 1.14.99.10
NAME        Steroid 21-monooxygenase
            Steroid 21-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
REACTION    Steroid + AH2 + O2 = 21-Hydroxysteroid + A + H2O
SUBSTRATE   Steroid
            AH2
            O2
PRODUCT     21-Hydroxysteroid
            A
            H2O
COFACTOR    Flavin
            Heme
COMMENT     An enzyme system involving a heme-thiolate protein (P-450) and
            flavoprotein. Formerly EC 1.14.1.8 and 1.99.1.11.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
GENES       MMU: 88591(Cyp21a1)
            HSA: 1589(CYP21A2)
DISEASE     MIM: 201910  Cytochrome P450, subfamily XXIA, polypeptide 2
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.10
            ExPASy - ENZYME nomenclature database: 1.14.99.10
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.10
            BRENDA, the Enzyme Database: 1.14.99.10
///
ENTRY       EC 1.14.99.11
NAME        Estradiol 6beta-monooxygenase
            Estradiol 6beta-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Estradiol-17beta,hydrogen-donor:oxygen oxidoreductase
            $ (6beta-hydroxylating)
REACTION    Estradiol-17beta + AH2 + O2 = 6beta-Hydroxyestradiol-17beta + A +
            H2O
SUBSTRATE   Estradiol-17beta
            AH2
            O2
PRODUCT     6beta-Hydroxyestradiol-17beta
            A
            H2O
COMMENT     Formerly EC 1.14.1.10 and 1.99.1.8.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.11
            ExPASy - ENZYME nomenclature database: 1.14.99.11
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.11
            BRENDA, the Enzyme Database: 1.14.99.11
///
ENTRY       EC 1.14.99.12
NAME        4-Androstene-3,17-dione monooxygenase
            Androstene-3,17-dione hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Androst-4-ene-3,17-dione,hydrogen-donor:oxygen oxidoreductase
            (13-hydroxylating, lactonizing)
REACTION    Androst-4-ene-3,17-dione + AH2 + O2 =
            3-Oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O
SUBSTRATE   Androst-4-ene-3,17-dione
            AH2
            O2
PRODUCT     3-Oxo-13,17-secoandrost-4-ene-17,13alpha-lactone
            A
            H2O
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.12
            ExPASy - ENZYME nomenclature database: 1.14.99.12
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.12
            BRENDA, the Enzyme Database: 1.14.99.12
///
ENTRY       EC 1.14.99.13
NAME        Transferred to EC 1.14.13.23
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
COMMENT     Transferred entry. Now EC 1.14.13.23 - 3-Hydroxybenzoate
            4-monooxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.13
            ExPASy - ENZYME nomenclature database: 1.14.99.13
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.13
///
ENTRY       EC 1.14.99.14
NAME        Progesterone 11alpha-monooxygenase
            Progesterone 11alpha-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Progesterone,hydrogen-donor:oxygen oxidoreductase
            (11alpha-hydroxylating)
REACTION    Progesterone + AH2 + O2 = 11alpha-Hydroxyprogesterone + A + H2O
SUBSTRATE   Progesterone
            AH2
            O2
PRODUCT     11alpha-Hydroxyprogesterone
            A
            H2O
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.14
            ExPASy - ENZYME nomenclature database: 1.14.99.14
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.14
            BRENDA, the Enzyme Database: 1.14.99.14
///
ENTRY       EC 1.14.99.15
NAME        4-Methoxybenzoate monooxygenase (O-demethylating)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     4-Methoxybenzoate,hydrogen-donor:oxygen oxidoreductase
            $ (O-demethylating)
REACTION    4-Methoxybenzoate + AH2 + O2 = 4-Hydroxybenzoate + Formaldehyde +
            A + H2O
SUBSTRATE   4-Methoxybenzoate
            AH2
            O2
            3-Ethoxybenzoate
            N-Methyl-4-aminobenzoate
            Toluate
PRODUCT     4-Hydroxybenzoate
            Formaldehyde
            A
            H2O
COMMENT     The bacterial enzyme consists of a ferredoxin-type protein and an
            iron-sulfur flavoprotein (FMN). Also acts on 4-ethoxybenzoate,
            N-methyl-4-aminobenzoate and toluate. The fungal enzyme acts best
            on veratrate.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.15
            ExPASy - ENZYME nomenclature database: 1.14.99.15
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.15
            UM-BBD (Biocatalysis/Biodegradation Database): 1.14.99.15
            BRENDA, the Enzyme Database: 1.14.99.15
///
ENTRY       EC 1.14.99.16
NAME        Methylsterol monooxygenase
            Methylsterol hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     4,4-Dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen
            $ oxidoreductase (hydroxylating)
REACTION    4,4-Dimethyl-5alpha-cholest-7-en-3beta-ol + AH2 + O2 =
            4beta-Hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol +
            A + H2O
SUBSTRATE   4,4-Dimethyl-5alpha-cholest-7-en-3beta-ol
            AH2
            O2
PRODUCT     4beta-Hydroxymethyl-4alpha-methyl-5alpha-cholest-7-en-3beta-ol
            A
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.16
            ExPASy - ENZYME nomenclature database: 1.14.99.16
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.16
            BRENDA, the Enzyme Database: 1.14.99.16
///
ENTRY       EC 1.14.99.17
NAME        Transferred to EC 1.14.16.5
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
COMMENT     Transferred entry. Now EC 1.14.16.5 - Glyceryl-ether
            monooxygenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.17
            ExPASy - ENZYME nomenclature database: 1.14.99.17
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.17
///
ENTRY       EC 1.14.99.18
NAME        N-Acetylneuraminate monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     N-Acetylneuraminate,hydrogen-donor:oxygen oxidoreductase
            $ (N-acetyl-hydroxylating)
REACTION    N-Acetylneuraminate + AH2 + O2 = N-Glycoloyl-neuraminate + A + H2O
SUBSTRATE   N-Acetylneuraminate
            AH2
            O2
            NADPH
            Ascorbate
PRODUCT     N-Glycoloyl-neuraminate
            A
            H2O
            NADP+
COFACTOR    Iron
COMMENT     Requires Fe2+. Either NADPH or ascorbate can act as AH2.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.18
            ExPASy - ENZYME nomenclature database: 1.14.99.18
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.18
            BRENDA, the Enzyme Database: 1.14.99.18
///
ENTRY       EC 1.14.99.19
NAME        Plasmanylethanolamine desaturase
            Alkylacylglycerophosphoethanolamine desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,
            $hydrogen-donor:oxygen oxidoreductase
REACTION    O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + AH2 + O2 =
            O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + A + 2 H2O
SUBSTRATE   O-1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamine
            AH2
            O2
            NADH
            NADPH
PRODUCT     O-1-Alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine
            A
            H2O
            NAD+
            NADP+
COFACTOR    Manganese
            ATP
COMMENT     Requires NADPH or NADH. May involve cytochrome b5. Requires Mg2+
            and ATP.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.19
            ExPASy - ENZYME nomenclature database: 1.14.99.19
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.19
            BRENDA, the Enzyme Database: 1.14.99.19
///
ENTRY       EC 1.14.99.20
NAME        Phylloquinone monooxygenase (2,3-epoxidizing)
            Phylloquinone epoxidase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Phylloquinone, hydrogen-donor:oxygen oxidoreductase
            $ (2,3-epoxidizing)
REACTION    Phylloquinone + AH2 + 2 O2 = 2,3-Epoxyphylloquinone + A + H2O
SUBSTRATE   Phylloquinone
            AH2
            O2
PRODUCT     2,3-Epoxyphylloquinone
            A
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.20
            ExPASy - ENZYME nomenclature database: 1.14.99.20
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.20
            BRENDA, the Enzyme Database: 1.14.99.20
///
ENTRY       EC 1.14.99.21
NAME        Latia-luciferin monooxygenase (demethylating)
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Latia-luciferin, hydrogen-donor:oxygen oxidoreductase
            $ (demethylating)
REACTION    Latia luciferin + AH2 + 2 O2 = Oxidized Latia luciferin + CO2 +
            Formate + A + H2O + hv
SUBSTRATE   Latia luciferin
            AH2
            O2
PRODUCT     Oxidized Latia luciferin
            CO2
            Formate
            A
            H2O
            hv
COFACTOR    FAD
COMMENT     A flavoprotein.  Latia luciferin is (E)-2-methyl-4-(2,6,6-
            -trimethyl-1-cyclohex-1-yl)-1-buten-1-ol formate.  The reaction
            possibly involves two enzymes, an oxygenase followed by a
            monooxygenase for the actual light-emitting step.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.21
            ExPASy - ENZYME nomenclature database: 1.14.99.21
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.21
            BRENDA, the Enzyme Database: 1.14.99.21
///
ENTRY       EC 1.14.99.22
NAME        Ecdysone 20-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Ecdysone, hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)
REACTION    Ecdysone + AH2 + O2 = 20-Hydroxyecdysone + A + H2O
SUBSTRATE   Ecdysone
            AH2
            O2
PRODUCT     20-Hydroxyecdysone
            A
            H2O
COMMENT     An enzyme from insect fat body or malpighian tubules involving a
            heme-thiolate protein (P-450).  NADPH can act as ultimate hydrogen
            donor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.22
            ExPASy - ENZYME nomenclature database: 1.14.99.22
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.22
            BRENDA, the Enzyme Database: 1.14.99.22
///
ENTRY       EC 1.14.99.23
NAME        3-Hydroxybenzoate 2-monooxygenase
            3-Hydroxybenzoate 2-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     3-Hydroxybenzoate, hydrogen-donor:oxygen oxidoreduxtase
            $ (2-hydroxylating)
REACTION    3-Hydroxybenzoate + AH2 + O2 = 2,3-Dihydroxybenzoate + A + H2O
SUBSTRATE   3-Hydroxybenzoate
            AH2
            O2
PRODUCT     2,3-Dihydroxybenzoate
            A
            H2O
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.23
            ExPASy - ENZYME nomenclature database: 1.14.99.23
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.23
            BRENDA, the Enzyme Database: 1.14.99.23
///
ENTRY       EC 1.14.99.24
NAME        Steroid 9alpha-monooxygenase
            Steroid 9alpha-hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Steroid, hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)
REACTION    Pregna-4,9(11)-diene-3,20-dione + AH2 + O2 = 9,11alpha-
            $Epoxypregn-4-ene-3,20-dione + Acceptor + H2O
SUBSTRATE   Pregna-4,9(11)-diene-3,20-dione
            AH2
            O2
PRODUCT     9,11alpha-Epoxypregn-4-ene-3,20-dione
            Acceptor
            H2O
COFACTOR    FMN
            Iron-sulfur
COMMENT     An enzyme system involving a flavoprotein (FMN) and two iron-
            -sulfur preteins.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.24
            ExPASy - ENZYME nomenclature database: 1.14.99.24
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.24
            BRENDA, the Enzyme Database: 1.14.99.24
///
ENTRY       EC 1.14.99.25
NAME        Linoleoyl-CoA desaturase
            delta6-Desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Linoleoyl-CoA, hydrogen-donor:oxygen oxidoreductase
REACTION    Linoleoyl-CoA + AH2 + O2 = gamma-Linolenoyl-CoA + A + 2 H2O
SUBSTRATE   Linoleoyl-CoA
            AH2
            O2
PRODUCT     gamma-Linolenoyl-CoA
            A
            H2O
COFACTOR    Iron
COMMENT     An iron protein.  The rat liver enzyme is an enzyme system
            involving cytochrome b5 and EC 1.6.2.2.
GENES       SYN: sll0262(desD)
            HSA: 9415(FADS2)
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.25
            ExPASy - ENZYME nomenclature database: 1.14.99.25
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.25
            BRENDA, the Enzyme Database: 1.14.99.25
///
ENTRY       EC 1.14.99.26
NAME        2-Hydroxypyridine 5-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     2-Hydroxypyridine, hydrogen-donor:oxygen oxidoreductase
            $(5-hydroxylating)
REACTION    2-Hydroxypyridine + AH2 + O2 = 2,5-Dihydroxypyridine + A + H2O
SUBSTRATE   2-Hydroxypyridine
            AH2
            O2
PRODUCT     2,5-Dihydroxypyridine
            A
            H2O
COMMENT     Also oxidizes 2,5-dihydroxypyridine, but does not act on
            3-hydroxypyridine, 4-hydroxypyridine or 2,6-dihydroxypyridine.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.26
            ExPASy - ENZYME nomenclature database: 1.14.99.26
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.26
            BRENDA, the Enzyme Database: 1.14.99.26
///
ENTRY       EC 1.14.99.27
NAME        Juglone 3-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     5-Hydroxy-1,4-naphthoquinone, hydrogen-donor:oxygen oxidoreductase
            $ (3-hydroxylating)
REACTION    5-Hydroxy-1,4-naphthoquinone + AH2 + O2 = 3,5-Dihydroxy-
            $1,4-naphthoquinone + A + H2O
SUBSTRATE   5-Hydroxy-1,4-naphthoquinone
            AH2
            O2
            1,4-Naphthoquinone
            Naphthazarin
            2-Chloro-1,4-naphthoquinone
PRODUCT     3,5-Dihydroxy-1,4-naphthoquinone
            A
            H2O
COMMENT     Also acts on 1,4-naphthoquinone, naphthazarin and 2-chloro-
            -1,4-naphthoquinone, but not on other related compounds.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.27
            ExPASy - ENZYME nomenclature database: 1.14.99.27
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.27
            BRENDA, the Enzyme Database: 1.14.99.27
///
ENTRY       EC 1.14.99.28
NAME        Linalool 8-monooxygenase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     3,7-Dimethylocta-1,6-dien-3-ol, hydrogen-donor:oxygen
            $ oxidoreductase (8-hydroxylating)
REACTION    3,7-Dimethylocta-1,6-dien-3-ol + AH2 + O2 = (E)-3,7-Dimethylocta
            $-1,6-diene-3,8-diol + A + H2O
SUBSTRATE   3,7-Dimethylocta-1,6-dien-3-ol
            AH2
            O2
PRODUCT     (E)-3,7-Dimethylocta-1,6-diene-3,8-diol
            A
            H2O
COFACTOR    Heme
COMMENT     A heme-thiolate protein (P-450).
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.28
            ExPASy - ENZYME nomenclature database: 1.14.99.28
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.28
            BRENDA, the Enzyme Database: 1.14.99.28
///
ENTRY       EC 1.14.99.29
NAME        Deoxyhypusine monooxygenase
            Deoxyhypusine hydroxylase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     Deoxyhypusine, hydrogen-donor:oxygen oxidoreductase
            $ (2-hydroxylating)
REACTION    Protein N6-(4-Aminobutyl]-L-lysine + AH2 + O2 = Protein
            $ N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine + A + H2O
SUBSTRATE   Protein N6-(4-Aminobutyl]-L-lysine
            AH2
            O2
PRODUCT     Protein N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine
            A
            H2O
COMMENT     The enzyme catalyses the final step in the formation of the amino
            acid hypusine in the eukaryotic initiating factor 4D.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.29
            ExPASy - ENZYME nomenclature database: 1.14.99.29
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.29
            BRENDA, the Enzyme Database: 1.14.99.29
///
ENTRY       EC 1.14.99.30
NAME        Carotene 7,8-desaturase
            Zeta-carotene desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
REACTION    Neurosporene + AH2 + O2 = Lycopene + A + 2 H2O
SUBSTRATE   Neurosporene
            AH2
            O2
PRODUCT     Lycopene
            A
            H2O
COMMENT     Also acts on zeta-carotene twice to give lycopene; on pro-zeta-
            carotene to give prolycopene; on beta-zeacarotene to give gamma-
            carotene.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.30
            ExPASy - ENZYME nomenclature database: 1.14.99.30
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.30
///
ENTRY       EC 1.14.99.31
NAME        Myristoyl-CoA 11-(E) desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     n-Tetradecanoyl-CoA, NADPH2:O2 oxidoreductase [11-(E) desaturating]
REACTION    Myristoyl-CoA + NAD(P)H2 + O2 = (E)-11-Tetradecenoyl-CoA + NAD(P) +
            2 H2O
SUBSTRATE   Myristoyl-CoA
            NADH
            NADPH
            O2
PRODUCT     (E)-11-Tetradecenoyl-CoA
            NAD
            NADP
            H2O
COMMENT     Involved in sex pheromone synthesis in Spodoptera littoralis. (E)-
            11-Tetradecenoyl-CoA is formed by stereospecific removal of the
            pro-(R) H at C-11 and the pro-(S) H at C-12. EC 1.14.99.32 forms
            the (Z) isomer by stereospecific cleavage of pro-(R) H at C-11 and
            C-12.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.31
            ExPASy - ENZYME nomenclature database: 1.14.99.31
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.31
///
ENTRY       EC 1.14.99.32
NAME        Myristoyl-CoA 11-(Z) desaturase
CLASS       Oxidoreductases
            Acting on paired donors with incorporation of molecular oxygen
            Miscellaneous
SYSNAME     n-Tetradecanoyl-CoA, NADPH2:O2 oxidoreductase [11-(Z) desaturating]
REACTION    Myristoyl-CoA + NAD(P)H + O2 = (Z)-11-Tetradecenoyl-CoA + NAD(P) +
            2 H2O
SUBSTRATE   Myristoyl-CoA
            NADH
            NADPH
            O2
PRODUCT     (Z)-11-Tetradecenoyl-CoA
            NAD
            NADP
            H2O
COMMENT     Involved in sex pheromone synthesis in Spodoptera littoralis. (Z)-
            11-Tetradecenoyl-CoA is formed by stereospecific removal of H from
            the pro-(R) positions at C-11 and C-12. EC 1.14.99.32 forms the
            (E)-isomer by removing the pro-(R) H group at C-11 and the pro-(S)
            H group at C-12.
DBLINKS     IUBMB Enzyme Nomenclature: 1.14.99.32
            ExPASy - ENZYME nomenclature database: 1.14.99.32
            WIT (What Is There) Metabolic Reconstruction: 1.14.99.32
///
ENTRY       EC 1.15.1.1
NAME        Superoxide dismutase
CLASS       Oxidoreductases
            Acting on superoxide radicals as acceptor
SYSNAME     Superoxide:superoxide oxidoreductase
REACTION    O2.- + O2.- + 2 H+ = O2 + H2O2
SUBSTRATE   O2.-
            H+
PRODUCT     O2
            H2O2
COFACTOR    Copper
            Zinc
            Manganese
            Iron
COMMENT     A metalloprotein; also known as erythrocuprein, hemocuprein or
            cytocuprein. Enzymes from most eucaryotes contain both copper and
            zinc; those from mitochondria and most procaryotes contain
            manganese or iron.
GENES       ECO: b1646(sodC) b1656(sodB) b3908(sodA)
            ECE: Z2347 Z2661(sodC) Z2678(sodB) Z3312 Z5453(sodA)
            ECS: ECs1120 ECs1989 ECs2355 ECs2365 ECs4834
            YPE: YPO2386(sodB) YPO3375(sodC) YPO4061(sodA)
            HIN: HI1088(sodA)
            PMU: PM0001(sodA) PM1952(sodC)
            XFA: XF1921 XF2614
            VCH: VC1583 VC2045 VC2694
            PAE: PA4366(sodB) PA4468(sodM)
            BUC: BU189(sodA)
            NME: NMB0884 NMB1398
            NMA: NMA1104(sodB) NMA1617(sodC)
            HPY: HP0389(sodB)
            HPJ: jhp0992
            CJE: Cj0169(sodB)
            RPR: RP535(sodB)
            RCO: RC0778(sodB)
            MLO: mlr7636
            SME: SMc00043(sodB) SMc02597(sodC)
            CCR: CC1579 CC1777 CC3557
            BSU: BG11676(sodA) BG12676(sodF) BG13565(yojM)
            BHA: BH1409(sodA) BH1563
            SAU: SA0128(sodM) SA1382(sodA)
            SAV: SAV0127 SAV1542(sodA)
            LLA: L12227(sodA)
            SPY: SPy1406(sodA)
            SPN: SP0766
            SPR: spr0674(sodA)
            CAC: CAC1363(sodC) CAC2567
            MTU: Rv0432(sodC) Rv3846(sodA)
            MTC: MT0447 MT3960
            MLE: ML0072(sodA) ML1925(sodC)
            CTR: CT294
            CMU: TC0567
            CPN: CPn0057
            CPA: CP0718
            CPJ: sodM
            BBU: BB0153(sodA)
            SYN: slr1516(sodB)
            DRA: DR1279 DR1546 DRA0202
            AAE: aq_1050(sodC1) aq_1499(sodA) aq_238(sodC2)
            MTH: MTH160(sod)
            HAL: VNG1190G(sod1) VNG1332G(sod2)
            TAC: Ta0013
            TVO: TVG0062871
            APE: APE0741
            SSO: SSO0316(sod)
            SCE: YHR008C(SOD2) YJR104C(SOD1)
            SPO: SOD1(sod1) SPAC1486.01(spac1486.01) SPBC16A3.14(spbc16a3.14)
            ATH: At1g08830(F22O13.32) At3g10920(F9F8.26) At4g25100(F13M23.240)
            CEL: C08A9.1 F55H2.1 ZK430.3 sod-2
            DME: CG11793(Sod) CG8905(Sod2)
            MMU: 103181(Sod3) 98351(Sod1) 98352(Sod2)
            HSA: 6647(SOD1) 6648(SOD2) 6649(SOD3)
DISEASE     MIM: 147450  Superoxide dismutase-1, soluble
            MIM: 147460  Superoxide dismutase-2, mitochondrial
            MIM: 185490  Superoxide dismutase-3, extracellular
MOTIF       PS: PS00087  [GA]-[IMFAT]-H-[LIVF]-H-x(2)-[GP]-[SDG]-x-[STAGDE]
            PS: PS00088  D-x-W-E-H-[STA]-[FY](2)
            PS: PS00332  G-[GN]-[SGA]-G-x-R-x-[SGA]-C-x(2)-[IV]
STRUCTURES  PDB: 1ABM  1AP5  1AP6  1AR5  1AVM  1AZV  1B06  1AR4  1B4T  1BA9  
                 1BS3  1B4L  1BT8  1BZO  1CB4  1CBJ  1COB  1D5N  1DSW  1DT0  
                 1E9O  1BSM  1EN4  1EN5  1EN6  1EQW  1ESO  1FUN  1EM1  1GN3  
                 1GN4  1GN6  1I08  1I0H  1IB5  1IBB  1IBD  1IBF  1IBH  1IDS  
                 1ISA  1ISB  1ISC  1JA8  1JCV  1JK9  1MFM  1MMM  1MNG  1GN2  
                 1QNM  1QNN  1SDA  1SDY  1SOS  1SPD  1SRD  1SSS  1SXA  1SXB  
                 1SXC  1SXN  1SXS  1SXZ  1VAR  1VEW  1XSO  1YAI  1YAZ  1YSO  
                 2JCW  2SOD  3MDS  3SDP  3SOD  4SOD  1MSD  
DBLINKS     IUBMB Enzyme Nomenclature: 1.15.1.1
            ExPASy - ENZYME nomenclature database: 1.15.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.15.1.1
            BRENDA, the Enzyme Database: 1.15.1.1
            SCOP (Structural Classification of Proteins): 1.15.1.1
///
ENTRY       EC 1.16.1.1
NAME        Mercury(II) reductase
CLASS       Oxidoreductases
            Oxidizing metal ions
            With NAD+ or NADP+ as acceptor
SYSNAME     Hg:NADP+ oxidoreductase
REACTION    Hg + NADP+ + H+ = Hg2+ + NADPH
SUBSTRATE   Hg
            NADP+
            H+
PRODUCT     Hg2+
            NADPH
COMMENT     A dithiol enzyme.
GENES       MLO: mll5241
            SME: SMb21143(merA2) SMc01717(merA1)
            SYN: slr1849(merA)
            TAC: Ta1341
            TVO: TVG0264489
            APE: APE1458
            SSO: SSO2689(merA)
            STO: ST1075
MOTIF       PS: PS00076  G-G-x-C-[LIVA]-x(2)-G-C-[LIVM]-P
            PS: PS01047  [LIVNS]-x(2)-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-
                         x(3)-[LIV]-x(9,11)-[IVA]-x-[LVFYS]
DBLINKS     IUBMB Enzyme Nomenclature: 1.16.1.1
            ExPASy - ENZYME nomenclature database: 1.16.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.16.1.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.16.1.1
            BRENDA, the Enzyme Database: 1.16.1.1
///
ENTRY       EC 1.16.1.2
NAME        Differic-transferrin reductase
            Transferrin reductase
CLASS       Oxidoreductases
            Oxidizing metal ions
            With NAD+ or NADP+ as acceptor
SYSNAME     Transferrin[Fe(II)]2:NAD+ oxidoreductase
REACTION    Transferrin[Fe(II)]2 + NAD+ = Transferrin[Fe(III)]2 + NADH
SUBSTRATE   Transferrin[Fe(II)]2
            NAD+
PRODUCT     Transferrin[Fe(III)]2
            NADH
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.16.1.2
            ExPASy - ENZYME nomenclature database: 1.16.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.16.1.2
            BRENDA, the Enzyme Database: 1.16.1.2
///
ENTRY       EC 1.16.3.1
NAME        Ferroxidase
CLASS       Oxidoreductases
            Oxidizing metal ions
            With oxygen as acceptor
SYSNAME     Fe(II):oxygen oxidoreductase
REACTION    4 Fe(II) + 4 H+ + O2 = 4 Fe(III) + 2 H2O
SUBSTRATE   Fe(II)
            H+
            O2
PRODUCT     Fe(III)
            H2O
COFACTOR    Copper
COMMENT     A multi-copper protein: ceruloplasmin from animals, rusticyanin in
            Thiobacillus ferroxidans.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       HSA: 1356
DISEASE     MIM: 117700  Ceruloplasmin
MOTIF       PS: PS00079  G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x(8)-G-[LM]-x(3)-
                         [LIVMFYW]
            PS: PS00080  H-C-H-x(3)-H-x(3)-[AG]-[LM]
STRUCTURES  PDB: 1KCW  
DBLINKS     IUBMB Enzyme Nomenclature: 1.16.3.1
            ExPASy - ENZYME nomenclature database: 1.16.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.16.3.1
            BRENDA, the Enzyme Database: 1.16.3.1
            SCOP (Structural Classification of Proteins): 1.16.3.1
///
ENTRY       EC 1.17.1.1
NAME        CDP-4-dehydro-6-deoxyglucose reductase
            CDP-4-keto-6-deoxyglucose reductase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With NAD+ or NADP+ as acceptor
SYSNAME     CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxydoreductase
REACTION    CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD+ or NADP+ + H2O =
            CDP-4-dehydro-6-deoxy-D-glucose + NADH or NADPH
SUBSTRATE   CDP-4-dehydro-3,6-dideoxy-D-glucose
            NAD+
            NADP+
PRODUCT     CDP-4-dehydro-6-deoxy-D-glucose
            NADH
            NADPH
COMMENT     Two proteins are involved but no partial reaction has been
            observed in the presence of either alone.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.17.1.1
            ExPASy - ENZYME nomenclature database: 1.17.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.17.1.1
            BRENDA, the Enzyme Database: 1.17.1.1
///
ENTRY       EC 1.17.3.1
NAME        Pteridine oxidase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With oxygen as acceptor
SYSNAME     2-Amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating)
REACTION    2-Amino-4-hydroxypteridine + O2 = 2-Amino-4,7-dihydroxypteridine
            + (?)
SUBSTRATE   2-Amino-4-hydroxypteridine
            O2
PRODUCT     2-Amino-4,7-dihydroxypteridine
COMMENT     Different from EC 1.2.3.2; does not act on hypoxanthine.
DBLINKS     IUBMB Enzyme Nomenclature: 1.17.3.1
            ExPASy - ENZYME nomenclature database: 1.17.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.17.3.1
            BRENDA, the Enzyme Database: 1.17.3.1
///
ENTRY       EC 1.17.4.1
NAME        Ribonucleoside-diphosphate reductase
            Ribonucleotide reductase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With a disulfide as acceptor
SYSNAME     2'-Deoxyribonucleoside-diphosphate:oxidized-thioredoxin
            2'-oxidoreductase
REACTION    2'-Deoxyribonucleoside diphosphate + Oxidized thioredoxin + H2O =
            Ribonucleoside diphosphate + Reduced thioredoxin
SUBSTRATE   2'-Deoxyribonucleoside diphosphate
            Oxidized thioredoxin
            H2O
PRODUCT     Ribonucleoside diphosphate
            Reduced thioredoxin
COFACTOR    Iron
            ATP
COMMENT     Requires ATP.  Nonheme diiron enzyme.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2234(nrdA) b2235(nrdB) b2675(nrdE) b2676(nrdF)
            ECE: Z3489(nrdA) Z3491(nrdB) Z3977(nrdE) Z3978(nrdF)
            ECS: ECs3117 ECs3118 ECs3538 ECs3539
            YPE: YPO1213(nrdB) YPO1214(nrdA) YPO2648(nrdF) YPO2649(nrdE)
            HIN: HI1659(nrdA) HI1660(nrdB)
            PMU: PM0717(nrdA) PM0719(nrdB)
            XFA: XF1196 XF1197
            VCH: VC1255 VC1256
            PAE: PA1155(nrdB) PA1156(nrdA)
            BUC: BU178(nrdB) BU179(nrdA)
            NME: NMB1288 NMB1291
            NMA: NMA1498(nrdB) NMA1501(nrdA)
            HPY: HP0364(nrdB) HP0680(nrdA)
            HPJ: jhp0621 jhp1016
            CJE: Cj0024(nrdA) Cj0231c(nrdB)
            RPR: RP512(nrdB) RP513(nrdA)
            RCO: RC0647(nrdA) RC0651(nrdB)
            MLO: mll0136
            SME: SMc01237(nrd)
            CCR: CC0260 CC3492
            BSU: BG11404(nrdE) BG11405(nrdF) BG13723(bnrdE) BG13725(bnrdF)
            BHA: BH0501(nrdA) BH0502(nrdB)
            SAU: SA0686(nrdE) SA0687(nrdF)
            SAV: SAV0718(nrdE) SAV0719(nrdF)
            LLA: L0294(nrdE) L0295(nrdF)
            SPY: SPy0425(nrdF.1) SPy0427(nrdE.1) SPy1375(nrdE.2)
                 SPy1378(nrdF.2)
            SPN: SP1179 SP1180
            SPR: spr1065(nrdE) spr1066(nrdF)
            CAC: CAC1047 CAC3276(nrdB) CAC3277(nrdA)
            MGE: MG229(nrdF) MG231(nrdE)
            MPN: F10_orf339(nrdF) F10_orf721(nrdE)
            MPU: MYPU_5390(nrdF) MYPU_5410(nrdE)
            MTU: Rv0233(nrdB) Rv0570(nrdZ) Rv1981c(nrdF) Rv3048c(nrdG)
                 Rv3051c(nrdE)
            MTC: MT0244 MT0596 MT2033 MT3133 MT3137
            MLE: ML1731(nrdF) ML1734(nrdE)
            CTR: CT827 CT828
            CMU: TC0214 TC0215
            CPN: CPn0984 CPn0985
            CPA: CP0871 CP0872
            CPJ: nrdA nrdB
            TPA: TP0053 TP1008
            SYN: slr0591(nrdF) slr1164(nrdA)
            DRA: DRB0108 DRB0109
            AAE: aq_094(nrdA) aq_1505(nrdF)
            TMA: TM0118
            MTH: MTH652
            AFU: AF1664(nrd)
            HAL: VNG1644G(nrdB2) VNG2383G(nrdA) VNG2384G(nrdB1)
            TAC: Ta1475
            TVO: TVG0096052
            PHO: PH0363
            PAB: PAB1057(nrd)
            APE: APE2062
            SSO: SSO0929(nrd) SSO2498(nrdB)
            STO: ST1259
            SCE: YER070W(RNR1) YGR180C(RNR4) YIL066C(RNR3) YJL026W(RNR2)
            SPO: CDC22(cdc22) SUC22(suc22)
            ATH: At2g21790(F7D8.11)
            CEL: C03C10.3 F19G12.2 T23G5.1
            DME: CG5371(RnrL) CG8975(RnrS)
            MMU: 98180(Rrm1)
            HSA: 6240(RRM1) 6241(RRM2)
DISEASE     MIM: 180390  Ribonucleotide reductase, M2 polypeptide
            MIM: 180410  Ribonucleotide reductase, M1 polypeptide
MOTIF       PS: PS00089  W-x(2)-[LIVF]-x(6,7)-G-[LIVM]-[FYRA]-[NH]-x(3)-
                         [STAQLIVM]-[ASC]-x(2)-[PA]
            PS: PS00368  [IVMSEQ]-E-x(1,2)-[LIVTA]-[HY]-[GSA]-x-[STAVM]-Y-x(2)-
                         [LIVMQ]-x(3)-[LIFY]-[IVFYCSA]
STRUCTURES  PDB: 1AV8  1BIQ  1JK0  1JPR  1JQC  1MRR  1PFR  1QFN  1R1R  1R2F  
                 1RIB  1RLR  1RNR  1XIK  1XSM  2AV8  2R1R  2R2F  3R1R  4R1R  
                 5R1R  6R1R  7R1R  1AFT  
DBLINKS     IUBMB Enzyme Nomenclature: 1.17.4.1
            ExPASy - ENZYME nomenclature database: 1.17.4.1
            WIT (What Is There) Metabolic Reconstruction: 1.17.4.1
            BRENDA, the Enzyme Database: 1.17.4.1
            SCOP (Structural Classification of Proteins): 1.17.4.1
///
ENTRY       EC 1.17.4.2
NAME        Ribonucleoside-triphosphate reductase
            Ribonucleotide reductase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With a disulfide as acceptor
SYSNAME     2'-Deoxyribonucleoside-triphosphate:oxydized-thioredoxin
            $ 2'-oxidoreductase
REACTION    2'-Deoxyribonucleoside triphosphate + Oxidized thioredoxin +
            H2O = Ribonucleoside triphosphate + Reduced thioredoxin
SUBSTRATE   2'-Deoxyribonucleoside triphosphate
            Oxidized thioredoxin
            H2O
PRODUCT     Ribonucleoside triphosphate
            Reduced thioredoxin
COFACTOR    Cobamide coenzyme
            Iron
            ATP
COMMENT     Requires a cobamide coenzyme and ATP.  Nonheme diiron enzyme.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b4238(nrdD)
            ECE: Z5848(nrdD)
            ECS: ECs5215
            YPE: YPO3454(nrdD)
            HIN: HI0075(nrdD)
            PMU: PM0940(nrdD)
            VCH: VCA0511
            SAU: SA2410(nrdD)
            SAV: SAV2601(nrdD)
            LLA: L70400(nrdD)
            SPY: SPy2110(nrdD)
            SPN: SP0202
            SPR: spr0183(nrdD)
            CAC: CAC0480(nrdD) CAC1209(nrdD)
            PHO: PH0021
            PAB: PAB2337
MOTIF       PS: PS00850  [STIV]-x-R-[IVT]-[CSA]-G-Y-x-[GACV]
STRUCTURES  PDB: 1B8B  
DBLINKS     IUBMB Enzyme Nomenclature: 1.17.4.2
            ExPASy - ENZYME nomenclature database: 1.17.4.2
            WIT (What Is There) Metabolic Reconstruction: 1.17.4.2
            BRENDA, the Enzyme Database: 1.17.4.2
            SCOP (Structural Classification of Proteins): 1.17.4.2
///
ENTRY       EC 1.17.99.1
NAME        4-Cresol dehydrogenase (hydroxylating)
            p-Cresol methylhydroxylase
CLASS       Oxidoreductases
            Acting on -CH2- groups
            With other acceptors
SYSNAME     4-Cresol:(acceptor) oxidoreductase (methyl-hydroxylating)
REACTION    4-Cresol + Acceptor + H2O = 4-Hydroxybenzaldehyde +
            Reduced acceptor
SUBSTRATE   4-Cresol
            4-Hydroxybenzaldehyde
            Acceptor
            Phenazine methosulfate
            H2O
PRODUCT     4-Hydroxybenzaldehyde
            Reduced acceptor
COFACTOR    FAD
            Cytochrome c
COMMENT     A flavocytochrome c (FAD). Phenazine methosulfate can act as
            acceptor. A quinone methide is probably formed as intermediate;
            the product is oxidized further to 4-hydroxybenzoate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00622  Toluene degradation
STRUCTURES  PDB: 1DII  1DIQ  
DBLINKS     IUBMB Enzyme Nomenclature: 1.17.99.1
            ExPASy - ENZYME nomenclature database: 1.17.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.17.99.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.17.99.1
            BRENDA, the Enzyme Database: 1.17.99.1
            SCOP (Structural Classification of Proteins): 1.17.99.1
///
ENTRY       EC 1.18.1.1
NAME        Rubredoxin--NAD+ reductase
            Rubredoxin reductase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     Rubredoxin:NAD+ oxidoreductase
REACTION    Reduced rubredoxin + NAD+ = Oxidized rubredoxin + NADH
SUBSTRATE   Reduced rubredoxin
            NAD+
PRODUCT     Oxidized rubredoxin
            NADH
COFACTOR    Iron
COMMENT     Contains iron at the redox centre. Formerly EC 1.6.7.2.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
STRUCTURES  PDB: 1BFY  
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.1.1
            ExPASy - ENZYME nomenclature database: 1.18.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.18.1.1
            BRENDA, the Enzyme Database: 1.18.1.1
            SCOP (Structural Classification of Proteins): 1.18.1.1
///
ENTRY       EC 1.18.1.2
NAME        Ferredoxin--NADP+ reductase
            Adrenodoxin reductase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     Ferredoxin:NADP+ oxidoreductase
REACTION    Reduced ferredoxin + NADP+ = Oxidized ferredoxin + NADPH
SUBSTRATE   Reduced ferredoxin
            NADP+
PRODUCT     Oxidized ferredoxin
            NADPH
COFACTOR    Flavin
COMMENT     A flavoprotein. Formerly EC 1.6.7.1 and 1.6.99.4.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b3924(fpr)
            ECE: Z5469(fpr)
            ECS: ECs4849
            YPE: YPO0088(fpr)
            XFA: XF1889
            PAE: PA3397(fpr) PA4615
            BUC: BU581(fpr)
            NME: NMB1044 NMB1450
            NMA: NMA1442(fpr) NMA1664
            MLO: mll4785
            SME: SMc02122(fpr)
            CCR: CC3208
            MTU: Rv0886(fprB) Rv3106(fprA)
            MTC: MT0909 MT3189
            MLE: ML0666(fprA) ML2134(fprB)
            SYN: slr1643(petH)
            DRA: DR0496
            DME: CG12390(dare)
            HSA: 2232(FDXR)
DISEASE     MIM: 103270  Ferredoxin reductase (adrenodoxin reductase)
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
STRUCTURES  PDB: 1BJK  1BX0  1BX1  1CJC  1E1L  1E62  1E63  1E64  1E6E  1EWY  
                 1FB3  1FDR  1FNB  1FNC  1FND  1FRN  1FRQ  1GAQ  1GAW  1JB9  
                 1QFY  1QFZ  1QG0  1QGA  1QUF  1B2R  1QUE  
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.1.2
            ExPASy - ENZYME nomenclature database: 1.18.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.18.1.2
            BRENDA, the Enzyme Database: 1.18.1.2
            SCOP (Structural Classification of Proteins): 1.18.1.2
///
ENTRY       EC 1.18.1.3
NAME        Ferredoxin--NAD+ reductase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     Ferredoxin:NAD+ oxidoreductase
REACTION    Reduced rubredoxin + NAD+ or NADP+ = Oxidized rubredoxin +
            NADH or NADPH
SUBSTRATE   Reduced rubredoxin
            NAD+
            NADP+
PRODUCT     Oxidized rubredoxin
            NADH
            NADPH
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00624  Xylene degradation
GENES       ECO: b2542(hcaD)
            ECE: Z3814(hcaD)
            ECS: ECs3408
            CCR: CC3525
MOTIF       PS: PS00197  C-{C}-{C}-[GA]-{C}-C-[GAST]-{CPDEKRHFYW}-C
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.1.3
            ExPASy - ENZYME nomenclature database: 1.18.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.18.1.3
            BRENDA, the Enzyme Database: 1.18.1.3
///
ENTRY       EC 1.18.1.4
NAME        Rubredoxin--NAD(P)+ reductase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With NAD+ or NADP+ as acceptor
SYSNAME     Rubredoxin:NAD(P)+ oxidoreductase
REACTION    Reduced rubredoxin + NAD+ or NADP+ = Oxidized rubredoxin +
            NADH or NADPH
SUBSTRATE   Reduced rubredoxin
            NADP+
            NAD+
PRODUCT     Oxidized rubredoxin
            NADPH
            NADH
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.1.4
            ExPASy - ENZYME nomenclature database: 1.18.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.18.1.4
            BRENDA, the Enzyme Database: 1.18.1.4
///
ENTRY       EC 1.18.3.1
NAME        Transferred to EC 1.18.99.1
            Hydrogenase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
COMMENT     Transferred entry. Now listed as EC 1.18.99.1 - Hydrogenase.
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.3.1
            ExPASy - ENZYME nomenclature database: 1.18.3.1
            WIT (What Is There) Metabolic Reconstruction: 1.18.3.1
///
ENTRY       EC 1.18.6.1
NAME        Nitrogenase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With dinitrogen as acceptor
SYSNAME     Reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing)
REACTION    3 Reduced ferredoxin + 6 H+ + N2 + n ATP = 3 Oxidized ferredoxin
            + 2 NH3 + n ADP + n Orthophosphate;
            8 H+ + 8 e- + 16 ATP + N2 + 16 H2O = H2 + 2 NH3 + 16 ADP +
            16 Orthophosphate;
            16 ATP + 16 H2O = 8 H+ + 8 e- + 16 ADP + 16 Orthophosphate;
            2 H+ + 2 e- + N2 = Diimine;
            2 H+ + 2 e- + Diimine = Hydrazine;
            2 H+ + 2 e- + Hydrazine = NH3;
            2 H+ + 2 e- = Hydrogen
SUBSTRATE   Reduced ferredoxin
            H+
            Acetylene
            N2
            ATP
PRODUCT     Oxidized ferredoxin
            NH3
            ADP
            Orthophosphate
INHIBITOR   Oxygen
COFACTOR    Iron-sulfur
            Molybdenum
            Homocitrate
COMMENT     An iron-molybdenum protein. Acetylene can also act as acceptor,
            in the absence of other acceptors. H+ is reduced to H2; n is
            about 12-18. Formerly EC 1.18.2.1. Consits of two proteins.
            Fe-protein is a dimer of identical subunits that contain one 
            [4Fe-4S] cluster and two ATP binding sites. Cluster and binding
            site is separated in a distance too large for direct coupling 
            between electron transfer and ATP hydrolysis.  MoFe-protein is a
            tetramer of a2b2 that contain iron and molybdenum. Each ab dimer
            contains two redox centers. (1) P-cluste pair, which consists of
            two linked [4Fe-4S] clusters bridged by two Cys thiol ligands and
            a SS-bond between an S atom in each of the two clusters. 
            (2) FeMo-cofactor, which consists of a [4Fe-3S] cluster and a 
            [Mo-3Fe-3S] cluster bridged by three nonprotein ligands; two
            sulfide ions, and an unknown third ligand. Mo atom is approxi-
            mately octahedrally coordinated by 3 S, a His imidazol N, and
            2 O from homocitrate.  Nitrogen is supposed to be oriented such
            that N=N bond is perpendicular to the axis between the two Fe
            in the FeMo-cofactor.  The sequence of the electron transfer is
            Fe-protein -> P-cluster pair -> FeMo-cofactor -> Nitrogen.
            Rapidly inactivated by oxygen. To escape from the inactivation,
            nitrogen fixation is carried out in heterocysts which is lack of
            photosystem II, or under the presence of leghemoglobin.
PATHWAY     PATH: MAP00625  Tetrachloroethene degradation
            PATH: MAP00910  Nitrogen metabolism
GENES       MLO: mlr5905 mlr5906 mlr5907 mlr5908
            SME: SMa0825(nifH) SMa0827(nifD) SMa0829(nifK) SMa0873(nifN)
            CAC: CAC0253(nifH) CAC0256(nifD) CAC0257(nifK) CAC0258(nifE)
            SYN: slr0749(chlL)
            MJA: MJ0879(nifH)
            MTH: MTH1482 MTH1560(NifH) MTH1563(NifD) MTH1564 MTH1565 MTH1566
                 MTH643
MOTIF       PS: PS00090  [STANQ]-[ET]-C-x(5)-G-D-[DN]-[LIVMT]-x-[STAGR]-
                         [LIVMFYST]
            PS: PS00692  D-x-L-G-D-V-V-C-G-G-F-[AGSP]-x-P
            PS: PS00699  [LIVMFYH]-[LIVMFST]-H-[AG]-[AGSP]-[LIVMNQA]-[AG]-C
            PS: PS00746  E-x-G-G-P-x(2)-[GA]-x-G-C-[AG]-G
STRUCTURES  PDB: 1G21  2MIN  1QH8  1QH1  1DE0  1FP6  3MIN  2NIP  1QGU  1N2C  
                 1G5P  1CP2  1G20  1G1M  
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.6.1
            ExPASy - ENZYME nomenclature database: 1.18.6.1
            WIT (What Is There) Metabolic Reconstruction: 1.18.6.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.18.6.1
            BRENDA, the Enzyme Database: 1.18.6.1
            SCOP (Structural Classification of Proteins): 1.18.6.1
///
ENTRY       EC 1.18.99.1
NAME        Hydrogenase
            Hydrogenlyase
CLASS       Oxidoreductases
            Acting on reduced ferredoxin as donor
            With H+ as acceptor
SYSNAME     Ferredoxin:H+ oxidoreductase
REACTION    2 Reduced ferredoxin + 2 H+ = 2 Oxidized ferredoxin + H2
SUBSTRATE   Reduced ferredoxin
            H+
            Hydrogen
PRODUCT     Oxidized ferredoxin
            H2
COFACTOR    Iron
            Nickel
            Sulfur
COMMENT     Contains iron-sulfur clusters, and enzymes from some sources
            contain nickel. Can use molecular hydrogen for the reduction of a
            variety of substances. Formerly EC 1.12.1.1, 1.12.7.1, 1.98.1.1
            and 1.18.3.1.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00680  Methane metabolism
GENES       ECO: b0972(hyaA) b0973(hyaB) b2994(hybC) b2997
            ECE: Z1389(hyaA) Z1390(hyaB) Z4348(hybC) Z4351
            ECS: ECs1128 ECs1129 ECs3879 ECs3882
            HPY: HP0631(hydA) HP0632(hydB)
            HPJ: jhp0574 jhp0575
            CJE: Cj1266c(hydB) Cj1267c(hydA) Cj1399c(hydA2)
            AAE: aq_660(mbhS1) aq_662(mbhL1) aq_802(mbhS3) aq_804(mbhL3)
                 aq_960(mbhL2) aq_965(mbhS2)
MOTIF       PS: PS00198  C-x(2)-C-x(2)-C-x(3)-C-[PEG]
            PS: PS00507  R-G-[LIVMF]-E-x(15)-[QESM]-R-x-C-G-[LIVM]-C
            PS: PS00508  [FY]-D-P-C-[LIM]-[ASG]-C-x(2,3)-H
STRUCTURES  PDB: 1C4C  1C4A  1HFE  1H2A  1CC1  1FEH  1FRF  2FRV  
DBLINKS     IUBMB Enzyme Nomenclature: 1.18.99.1
            ExPASy - ENZYME nomenclature database: 1.18.99.1
            WIT (What Is There) Metabolic Reconstruction: 1.18.99.1
            UM-BBD (Biocatalysis/Biodegradation Database): 1.18.99.1
            BRENDA, the Enzyme Database: 1.18.99.1
            SCOP (Structural Classification of Proteins): 1.18.99.1
///
ENTRY       EC 1.19.6.1
NAME        Nitrogenase (flavodoxin)
CLASS       Oxidoreductases
            Acting on reduced flavodoxin as donor
            With dinitrogen as acceptor
SYSNAME     Reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing)
REACTION    6 Reduced flavodoxin + 6 H+ + N2 + n ATP = 6 Oxidized flavodoxin
            + 2 NH3 + n ADP + n Orthophosphate
SUBSTRATE   Reduced flavodoxin
            H+
            N2
            ATP
PRODUCT     Oxidized flavodoxin
            NH3
            ADP
            Orthophosphate
COFACTOR    Iron-sulfur
            Molybdenum
COMMENT     The enzyme is a complex of two proteins containing iron-sulfur
            centers and molybdenum.  Formerly EC 1.19.2.1.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       AFU: AF2332
DBLINKS     IUBMB Enzyme Nomenclature: 1.19.6.1
            ExPASy - ENZYME nomenclature database: 1.19.6.1
            WIT (What Is There) Metabolic Reconstruction: 1.19.6.1
            BRENDA, the Enzyme Database: 1.19.6.1
///
ENTRY       EC 1.97.1.1
NAME        Chlorate reductase
CLASS       Oxidoreductases
            Other oxidoreductases
SYSNAME     Chlorite:acceptor oxidoreductase
REACTION    AH2 + Chlorate = A + H2O + Chlorite
SUBSTRATE   AH2
            Chlorate
            Flavin
            Benzyl viologen
PRODUCT     A
            H2O
            Chlorite
COMMENT     Flavins or benzyl viologen can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 1.97.1.1
            ExPASy - ENZYME nomenclature database: 1.97.1.1
            WIT (What Is There) Metabolic Reconstruction: 1.97.1.1
            BRENDA, the Enzyme Database: 1.97.1.1
///
ENTRY       EC 1.97.1.2
NAME        Pyrogallol hydroxyltransferase
CLASS       Oxidoreductases
            Other oxidoreductases
SYSNAME     1,2,3,5-Tetrahydroxybenzene:1,2,3-trihydroxybenzene
            $ hydroxytransferase
REACTION    1,2,3,5-Tetrahydroxybenzene + 1,2,3-Trihydroxybenzene =
            1,3,5-Trihydroxybenzene + 1,2,3,5-Tetrahydroxybenzene
SUBSTRATE   1,2,3,5-Tetrahydroxybenzene
            1,2,3-Trihydroxybenzene
PRODUCT     1,3,5-Trihydroxybenzene
            1,2,3,5-Tetrahydroxybenzene
COMMENT     1,2,3,5-Tetrahydroxybenzene acts as a co-substrate for the
            conversion of pyrogallol into phloroglucinol, and for a number of
            similar isomerizations.  The enzyme is provisionally listed here,
            but might be considered as the vasis for a new class in the
            transferases, analogous to the aminotransferases.
DBLINKS     IUBMB Enzyme Nomenclature: 1.97.1.2
            ExPASy - ENZYME nomenclature database: 1.97.1.2
            WIT (What Is There) Metabolic Reconstruction: 1.97.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 1.97.1.2
            BRENDA, the Enzyme Database: 1.97.1.2
///
ENTRY       EC 1.97.1.3
NAME        Sulfur reductase
CLASS       Oxidoreductases
            Other oxidoreductases
SYSNAME     Sulfur oxidoreductase
REACTION    Sulfur + Donor = H2S + Oxidized donor
SUBSTRATE   Sulfur
            Donor
PRODUCT     H2S
            Oxidized donor
DBLINKS     IUBMB Enzyme Nomenclature: 1.97.1.3
            ExPASy - ENZYME nomenclature database: 1.97.1.3
            WIT (What Is There) Metabolic Reconstruction: 1.97.1.3
            BRENDA, the Enzyme Database: 1.97.1.3
///
ENTRY       EC 1.97.1.4
NAME        [Pyruvate Formate-lyase] activating enzyme
            PFL activase
CLASS       Oxidoreductases
            Other oxidoreductases
REACTION    S-Adenosyl-L-methionine + Dihydroflavodoxin +
            [Pyruvate formate-lyase]-glycine = 5'-Deoxyadenosine + Methionine +
            Flavodoxin + [Pyruvate formate-lyase]-glycine radical
SUBSTRATE   S-Adenosyl-L-methionine
            Dihydroflavodoxin
            [Pyruvate formate-lyase]-glycine
PRODUCT     5'-Deoxyadenosine
            Methionine
            Flavodoxin
            [Pyruvate formate-lyase]-glycine radical
COMMENT     A single Glycine residue in Pyruvate Formate-lyase (EC 2.3.1.54) is
            oxidised to the corresponding radical Glycine, by transfer of H
            from its CH2 into adomet with concomitant cleavage of the latter.
GENES       ECO: b0824(ybiY) b0902(pflA) b3952(pflC) b4237(nrdG)
            ECE: Z1047(ybiY) Z1246(pflA) Z5508(pflC) Z5847(nrdG)
            ECS: ECs0902 ECs0985 ECs4881
            YPE: YPO1381(pflA)
            HIN: HI0179(pflA) HI1155(nrdG)
            PMU: PM0077(act) PM0941(nrdG)
            VCH: VC1869 VCA0512
            SAU: SA0219(pflA) SA2409
            SAV: SAV0221(pflC) SAV2600
            LLA: L63811(pflA) L72609(nrdG)
            SPY: SPy0379(pflC) SPy2055 SPy2105(nrdG)
            SPN: SP0205 SP0245 SP1976
            SPR: spr0185(nrdG) spr0226(pflE) spr1791(pflC)
            CAC: CAC0481(nrdG) CAC0981(pflA) CAC1421 CAC3242
            MTU: Rv3138(pflA)
            MTC: MT3225
            AAE: aq_1861 aq_729
            TMA: TM0109 TM0924 TM1237 TM1552
            MJA: MJ0674 MJ0808 MJ1227(act)
            MTH: MTH1069 MTH1395 MTH1586 MTH1643 MTH1784 MTH345 MTH976
            AFU: AF0117(act-1) AF0918(act-2) AF1330(act-3) AF1450(pflC)
                 AF1961(pflX) AF2278(act-4)
            TAC: Ta0248
            TVO: TVG1422495
            PHO: PH0020 PH1113 PH1391
            PAB: PAB0742(pflX) PAB1859 PAB2338
            APE: APE1535 APE1865
            SSO: SSO0653
MOTIF       PS: PS01087  [GV]-x-G-x-[KR]-x(3)-F-x(2)-G-x(0,1)-C-x(3)-C-x(2)-C-x-
                         [NL]
DBLINKS     IUBMB Enzyme Nomenclature: 1.97.1.4
            ExPASy - ENZYME nomenclature database: 1.97.1.4
            WIT (What Is There) Metabolic Reconstruction: 1.97.1.4
///
ENTRY       EC 2.1.1.1
NAME        Nicotinamide N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:nicotinamide N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Nicotinamide = S-Adenosyl-L-homocysteine
            + 1-Methylnicotinamide
SUBSTRATE   S-Adenosyl-L-methionine
            Nicotinamide
PRODUCT     S-Adenosyl-L-homocysteine
            1-Methylnicotinamide
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       HSA: 4837(NNMT)
DISEASE     MIM: 600008  Nicotinamide N-methyltransferase
MOTIF       PS: PS01100  L-I-D-I-G-S-G-P-T-[IV]-Y-Q-[LV]-L-[SA]-A-C
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.1
            ExPASy - ENZYME nomenclature database: 2.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.1
            BRENDA, the Enzyme Database: 2.1.1.1
///
ENTRY       EC 2.1.1.2
NAME        Guanidinoacetate N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:guanidinoacetate N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Guanidinoacetate =
            S-Adenosyl-L-homocysteine + Creatine
SUBSTRATE   S-Adenosyl-L-methionine
            Guanidinoacetate
PRODUCT     S-Adenosyl-L-homocysteine
            Creatine
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       HSA: 2593(GAMT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.2
            ExPASy - ENZYME nomenclature database: 2.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.2
            BRENDA, the Enzyme Database: 2.1.1.2
///
ENTRY       EC 2.1.1.3
NAME        Thetin--homocysteine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     Dimethylsulfonioacetate:L-homocysteine S-methyltransferase
REACTION    Dimethylsulfonioacetate + L-Homocysteine = S-Methylthioglycolate
            + L-Methionine
SUBSTRATE   Dimethylsulfonioacetate
            L-Homocysteine
PRODUCT     S-Methylthioglycolate
            L-Methionine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.3
            ExPASy - ENZYME nomenclature database: 2.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.3
            BRENDA, the Enzyme Database: 2.1.1.3
///
ENTRY       EC 2.1.1.4
NAME        Acetylserotonin N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
REACTION    S-Adenosyl-L-methionine + N-Acetylserotonin =
            S-Adenosyl-L-homocysteine + N-Acetyl-5-methoxytryptamine
SUBSTRATE   S-Adenosyl-L-methionine
            N-Acetylserotonin
            Hydroxyindole
PRODUCT     S-Adenosyl-L-homocysteine
            N-Acetyl-5-methoxytryptamine
COMMENT     Some other hydroxyindoles also act as acceptor, more slowly.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       HSA: 438(ASMT)
DISEASE     MIM: 402500  Acetylserotonin methyltransferase (Y chromosome)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.4
            ExPASy - ENZYME nomenclature database: 2.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.4
            BRENDA, the Enzyme Database: 2.1.1.4
///
ENTRY       EC 2.1.1.5
NAME        Betaine--homocysteine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     Trimethylaminoacetate:L-homosysteine S-methyltransferase
REACTION    Trimethylaminoacetate + L-Homocysteine = Dimethylglycine +
            L-Methionine
SUBSTRATE   Trimethylaminoacetate
            L-Homocysteine
PRODUCT     Dimethylglycine
            L-Methionine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00271  Methionine metabolism
GENES       MLO: mlr1281
            HSA: 635(BHMT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.5
            ExPASy - ENZYME nomenclature database: 2.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.5
            BRENDA, the Enzyme Database: 2.1.1.5
///
ENTRY       EC 2.1.1.6
NAME        Catechol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:catechol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Catechol =
            S-Adenosyl-L-homocysteine + Guaiacol
SUBSTRATE   S-Adenosyl-L-methionine
            Catechol
            Catecholamine
            (R)-(-)-Adrenaline
            Noradrenaline
PRODUCT     S-Adenosyl-L-homocysteine
            Guaiacol
COMMENT     The mammalian enzyme acts more rapidly on catecholamines such as
            adrenaline or noradrenaline than on catechols.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       HSA: 1312(COMT)
DISEASE     MIM: 116790  Catechol-O-methyltransferase
STRUCTURES  PDB: 1VID  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.6
            ExPASy - ENZYME nomenclature database: 2.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.6
            BRENDA, the Enzyme Database: 2.1.1.6
            SCOP (Structural Classification of Proteins): 2.1.1.6
///
ENTRY       EC 2.1.1.7
NAME        Nicotinate N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:nicotinate N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Nicotinate = S-Adenosyl-L-homocysteine
            + N-Methylnicotinate
SUBSTRATE   S-Adenosyl-L-methionine
            Nicotinate
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylnicotinate
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.7
            ExPASy - ENZYME nomenclature database: 2.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.7
            BRENDA, the Enzyme Database: 2.1.1.7
///
ENTRY       EC 2.1.1.8
NAME        Histamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
REACTION    S-Adenosyl-L-methionine + Histamine = S-Adenosyl-L-homocysteine +
            N-Methylhistamine
SUBSTRATE   S-Adenosyl-L-methionine
            Histamine
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylhistamine
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       HSA: 3176(HNMT)
DISEASE     MIM: 605238  Histamine N-methyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.8
            ExPASy - ENZYME nomenclature database: 2.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.8
            BRENDA, the Enzyme Database: 2.1.1.8
///
ENTRY       EC 2.1.1.9
NAME        Thiol S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:thiol S-methyltransferase
REACTION    S-Adenosyl-L-methionine + a Thiol = S-Adenosyl-L-homocysteine +
            a Thioether
SUBSTRATE   S-Adenosyl-L-methionine
            Thiol
            H2S
PRODUCT     S-Adenosyl-L-homocysteine
            Thioether
COMMENT     H2S and a variety of alkyl, aryl and heterocyclic thiols and
            hydroxy thiols can act as acceptors.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.9
            ExPASy - ENZYME nomenclature database: 2.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.9
            UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.9
            BRENDA, the Enzyme Database: 2.1.1.9
///
ENTRY       EC 2.1.1.10
NAME        Homocysteine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:L-homocysteine S-methyltransferase
REACTION    S-Adenosyl-L-methionine + L-Homocysteine =
            S-Adenosyl-L-homocysteine + L-Methionine
SUBSTRATE   S-Adenosyl-L-methionine
            L-Homocysteine
PRODUCT     S-Adenosyl-L-homocysteine
            L-Methionine
COMMENT     The bacterial enzyme uses S-methylmethionine as donor more
            actively than S-adenosylmethionine.
PATHWAY     PATH: MAP00271  Methionine metabolism
GENES       ECO: b0261(yagD)
            BSU: BG12751(ybgG)
            CAC: CAC3348
            MTU: Rv2458
            MTC: MT2533
            MLE: ML1478
            ATH: At3g25900(MPE11.15) At3g63250(F16M2.100)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.10
            ExPASy - ENZYME nomenclature database: 2.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.10
            BRENDA, the Enzyme Database: 2.1.1.10
///
ENTRY       EC 2.1.1.11
NAME        Magnesium-protoporphyrin O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:magnesium-protoporphyrin O-methyltrans
            $ferase
REACTION    S-Adenosyl-L-methionine + Magnesium protoporphyrin =
            S-Adenosyl-L-homocysteine +
            Magnesium protoporphyrin monomethyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Magnesium protoporphyrin
PRODUCT     S-Adenosyl-L-homocysteine
            Magnesium protoporphyrin monomethyl ester
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.11
            ExPASy - ENZYME nomenclature database: 2.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.11
            BRENDA, the Enzyme Database: 2.1.1.11
///
ENTRY       EC 2.1.1.12
NAME        Methionine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:L-methionine S-methyltransferase
REACTION    S-Adenosyl-L-methionine + L-Methionine =
            S-Adenosyl-L-homocysteine + S-Methyl-L-methionine
SUBSTRATE   S-Adenosyl-L-methionine
            L-Methionine
PRODUCT     S-Adenosyl-L-homocysteine
            S-Methyl-L-methionine
COFACTOR    Zn2+
            Mn2+
COMMENT     Requires Zn2+ or Mn2+.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.12
            ExPASy - ENZYME nomenclature database: 2.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.12
            BRENDA, the Enzyme Database: 2.1.1.12
///
ENTRY       EC 2.1.1.13
NAME        5-Methyltetrahydrofolate--homocysteine S-methyltransferase
            Methionine synthase
            Tetrahydropteroylglutamate methyltramsferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5-Methyltetrahydrofolate:L-homocysteine S-methyltransferase
REACTION    5-Methyltetrahydrofolate + L-Homocysteine = Tetrahydrofolate +
            L-Methionine
SUBSTRATE   5-Methyltetrahydrofolate
            L-Homocysteine
            5-Methyltetrahydropteroyl-L-glutamate
            5-Methyltetrahydropteroyltri-L-glutamate
            S-Adenosyl-L-methionine
PRODUCT     Tetrahydrofolate
            L-Methionine
            Tetrahydropteroyl-L-glutamate
            Tetrahydropteroyltri-L-glutamate
COFACTOR    Cobamide
            FAD
COMMENT     A cobamide-protein. The bacterial enzyme requires S-adenosyl-
            -L-methionine and reduced FAD. Acts on monoglutamate or
            triglutamate derivatives.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b4019(metH)
            ECE: Z5610(metH)
            ECS: ECs4937
            YPE: YPO3722(metH)
            VCH: VC0390
            PAE: PA1843(metH)
            SME: SMc03112(metH)
            CCR: CC2137 CC2138
            BHA: BH1630(metH)
            CAC: CAC0578(metH)
            MTU: Rv2124c(metH)
            MTC: MT2183
            MLE: ML1307(metH)
            SYN: slr0212(metH)
            DRA: DR0966
            TMA: TM0268
            CEL: R03D7.1(nos-1)
            HSA: 4548(MTR)
DISEASE     MIM: 156570  5-methyltetrahydrofolate-homocysteine
                         methyltransferase 1
STRUCTURES  PDB: 1BMT  1MSK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.13
            ExPASy - ENZYME nomenclature database: 2.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.13
            BRENDA, the Enzyme Database: 2.1.1.13
            SCOP (Structural Classification of Proteins): 2.1.1.13
///
ENTRY       EC 2.1.1.14
NAME        5-Methyltetrahydropteroyltriglutamate--homocysteine
            $ S-methyltransferase
            Tetrahydropteroyltriglutamate methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine
            S-methyltransferase
REACTION    5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine =
            Tetrahydropteroyltri-L-glutamate + L-Methionine
SUBSTRATE   5-Methyltetrahydropteroyltri-L-glutamate
            L-Homocysteine
PRODUCT     Tetrahydropteroyltri-L-glutamate
            L-Methionine
COFACTOR    Phosphate
COMMENT     Requires phosphate. The enzyme from E. coli also requires a
            reducing system.
PATHWAY     PATH: MAP00271  Methionine metabolism
GENES       ECO: b3829(metE)
            ECE: Z5351(metE)
            ECS: ECs4759
            YPE: YPO3788(metE)
            HIN: HI1702(metE)
            PMU: PM0420(metE)
            XFA: XF2272
            VCH: VC1704
            PAE: PA1927(metE)
            BUC: BU030(metE)
            NME: NMB0944
            NMA: NMA1140(metE)
            CJE: Cj1201(metE)
            MLO: mll6123
            CCR: CC0482
            BSU: BG12616(metC)
            BHA: BH0438
            SAU: SA0344(metE)
            SAV: SAV0345(metC)
            LLA: L0100(metE)
            SPN: SP0585
            SPR: spr0514(metE)
            MTU: Rv1133c(metE)
            MTC: MT1165
            MLE: ML0961(metE)
            AAE: aq_1710(metE)
            TMA: TM1286
            MJA: MJ1473(metE)
            MTH: MTH775
            AFU: AF2112(metE)
            TAC: Ta0977
            TVO: TVG1176554
            PHO: PH1089
            PAB: PAB0608(metE-like1)
            APE: APE2048
            SSO: SSO0407(metE-2)
            STO: ST0385
            SCE: YER091C(MET6)
            SPO: SPAC9.09(spac9.09)
            ATH: At3g03780(F20H23.19) At5g17920(MPI7.60)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.14
            ExPASy - ENZYME nomenclature database: 2.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.14
            BRENDA, the Enzyme Database: 2.1.1.14
///
ENTRY       EC 2.1.1.15
NAME        Fatty-acid O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:fatty-acid O-methyltransferase
REACTION    S-Adenosyl-L-methionine + a Fatty acid =
            S-Adenosyl-L-homocysteine + a Fatty acid methyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Fatty acid
            Oleic acid
PRODUCT     S-Adenosyl-L-homocysteine
            Fatty acid methyl ester
            Oleic acid methyl ester
COMMENT     Oleic acid is the most effective fatty acid acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.15
            ExPASy - ENZYME nomenclature database: 2.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.15
            BRENDA, the Enzyme Database: 2.1.1.15
///
ENTRY       EC 2.1.1.16
NAME        Methylene-fatty-acyl-phospholipid synthase
            Unsaturated-phospholipid methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:unsaturated-phospholipid methyltransferase
            (methenylating)
REACTION    S-Adenosyl-L-methionine + Phospholipid olefinic fatty acid =
            S-Adenosyl-L-homocysteine + Phospholipid methylene fatty acid
SUBSTRATE   S-Adenosyl-L-methionine
            Phospholipid olefinic fatty acid
PRODUCT     S-Adenosyl-L-homocysteine
            Phospholipid methylene fatty acid
COMMENT     The enzyme transfers a methyl group to the 10-position
            of a delta-olefinic acyl chain in phosphatidylglycerol or
            phosphatidylinositol or, more slowly, phosphatidylethanolamine;
            subsequent proton transfer produces a 10-methylene group (cf.
            EC 2.1.1.79).
GENES       SCE: YJR073C(OPI3)
            SPO: CHO1(cho1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.16
            ExPASy - ENZYME nomenclature database: 2.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.16
            BRENDA, the Enzyme Database: 2.1.1.16
///
ENTRY       EC 2.1.1.17
NAME        Phosphatidylethanolamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:phosphatidylethanolamine
            N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Phosphatidylethanolamine =
            S-Adenosyl-L-homocysteine + Phosphatidyl-N-methylethanolamine
SUBSTRATE   S-Adenosyl-L-methionine
            Phosphatidylethanolamine
PRODUCT     S-Adenosyl-L-homocysteine
            Phosphatidyl-N-methylethanolamine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       SCE: YGR157W(CHO2)
            HSA: 10400(PEMT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.17
            ExPASy - ENZYME nomenclature database: 2.1.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.17
            BRENDA, the Enzyme Database: 2.1.1.17
///
ENTRY       EC 2.1.1.18
NAME        Polysaccharide O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 1,4-alpha-D-Glucooligosaccharide =
            S-Adenosyl-L-homocysteine +
            Oligosaccharide containing 6-methyl-D-glucose units
SUBSTRATE   S-Adenosyl-L-methionine
            1,4-alpha-D-Glucooligosaccharide
PRODUCT     S-Adenosyl-L-homocysteine
            Oligosaccharide containing 6-methyl-D-glucose units
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.18
            ExPASy - ENZYME nomenclature database: 2.1.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.18
            BRENDA, the Enzyme Database: 2.1.1.18
///
ENTRY       EC 2.1.1.19
NAME        Trimethylsulfonium--tetrahydrofolate N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     Trimethylsulfonium:tetrahydrofolate N-methyltransferase
REACTION    Trimethylsulfonium + Tetrahydrofolate = Dimethyl sulfide +
            5-Methyltetrahydrofolate
SUBSTRATE   Trimethylsulfonium
            Tetrahydrofolate
PRODUCT     Dimethyl sulfide
            5-Methyltetrahydrofolate
PATHWAY     PATH: MAP00670  One carbon pool by folate
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.19
            ExPASy - ENZYME nomenclature database: 2.1.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.19
            BRENDA, the Enzyme Database: 2.1.1.19
///
ENTRY       EC 2.1.1.20
NAME        Glycine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:glycine methyltransferase
REACTION    S-Adenosyl-L-methionine + Glycine =
            S-Adenosyl-L-homocysteine + Sarcosine
SUBSTRATE   S-Adenosyl-L-methionine
            Glycine
PRODUCT     S-Adenosyl-L-homocysteine
            Sarcosine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       HSA: 27232(GNMT)
STRUCTURES  PDB: 1BHJ  1D2C  1D2G  1D2H  1XVA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.20
            ExPASy - ENZYME nomenclature database: 2.1.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.20
            BRENDA, the Enzyme Database: 2.1.1.20
            SCOP (Structural Classification of Proteins): 2.1.1.20
///
ENTRY       EC 2.1.1.21
NAME        Methylamine--glutamate N-methyltransferase
            N-Methylglutamate synthase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     Methylamine:L-glutamate N-methyltransferase
REACTION    Methylamine + L-Glutamate = NH3 + N-Methyl-L-glutamate
SUBSTRATE   Methylamine
            L-Glutamate
PRODUCT     NH3
            N-Methyl-L-glutamate
PATHWAY     PATH: MAP00680  Methane metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.21
            ExPASy - ENZYME nomenclature database: 2.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.21
            BRENDA, the Enzyme Database: 2.1.1.21
///
ENTRY       EC 2.1.1.22
NAME        Carnosine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:carnosine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Carnosine = S-Adenosyl-L-homocysteine +
            Anserine
SUBSTRATE   S-Adenosyl-L-methionine
            Carnosine
PRODUCT     S-Adenosyl-L-homocysteine
            Anserine
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.22
            ExPASy - ENZYME nomenclature database: 2.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.22
            BRENDA, the Enzyme Database: 2.1.1.22
///
ENTRY       EC 2.1.1.23
NAME        Transferred to EC 2.1.1.124, 2.1.1.125 and 2.1.1.126
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
COMMENT     Transferred entry. Now included in EC 2.1.1.124 - [Cytochrome c]
            Methionine S-methyltransferase, 2.1.1.125 - Histone-Arginine
            N-methyltransferase, and 2.1.1.126 - [Myeline basic protein]-
            Arginine N-methyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.23
            ExPASy - ENZYME nomenclature database: 2.1.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.23
            BRENDA, the Enzyme Database: 2.1.1.23
///
ENTRY       EC 2.1.1.24
NAME        Deleted entry
            Protein-gamma-glutamate O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
COMMENT     Deleted entry. Now listed as EC 2.1.1.77, 2.1.1.80 and
            2.1.1.100.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.24
            ExPASy - ENZYME nomenclature database: 2.1.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.24
///
ENTRY       EC 2.1.1.25
NAME        Phenol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:phenol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Phenol = S-Adenosyl-L-homocysteine +
            Anisole
SUBSTRATE   S-Adenosyl-L-methionine
            Phenol
PRODUCT     S-Adenosyl-L-homocysteine
            Anisole
COMMENT     Acts on a wide variety of simple alkyl-, methoxy- and halo-
            phenols.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.25
            ExPASy - ENZYME nomenclature database: 2.1.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.25
            BRENDA, the Enzyme Database: 2.1.1.25
///
ENTRY       EC 2.1.1.26
NAME        Iodophenol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:2-iodophenol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 2-Iodophenol =
            S-Adenosyl-L-homocysteine + 2-Iodophenol methyl ether
SUBSTRATE   S-Adenosyl-L-methionine
            2-Iodophenol
PRODUCT     S-Adenosyl-L-homocysteine
            2-Iodophenol methyl ether
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.26
            ExPASy - ENZYME nomenclature database: 2.1.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.26
            BRENDA, the Enzyme Database: 2.1.1.26
///
ENTRY       EC 2.1.1.27
NAME        Tyramine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tyramine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Tyramine = S-Adenosyl-L-homocysteine +
            N-Methyltyramine
SUBSTRATE   S-Adenosyl-L-methionine
            Tyramine
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methyltyramine
COMMENT     Has some activity on phenylethylamine analogues.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.27
            ExPASy - ENZYME nomenclature database: 2.1.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.27
            BRENDA, the Enzyme Database: 2.1.1.27
///
ENTRY       EC 2.1.1.28
NAME        Phenylethanolamine N-methyltransferase
            Noradrenalin N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Phenylethanolamine =
            S-Adenosyl-L-homocysteine + N-Methylphenylethanolamine
SUBSTRATE   S-Adenosyl-L-methionine
            Phenylethanolamine
            Noradrenaline
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylphenylethanolamine
            (R)-(-)-Adrenaline
COMMENT     Acts on various phenylethanolamines; converts noradrenaline
            into adrenaline.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       HSA: 5409(PNMT)
DISEASE     MIM: 171190  Phenylethanolamine N-methyltransferase
MOTIF       PS: PS01100  L-I-D-I-G-S-G-P-T-[IV]-Y-Q-[LV]-L-[SA]-A-C
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.28
            ExPASy - ENZYME nomenclature database: 2.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.28
            BRENDA, the Enzyme Database: 2.1.1.28
///
ENTRY       EC 2.1.1.29
NAME        tRNA (cytosine-5-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing 5-methylcytosine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing 5-methylcytosine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.29
            ExPASy - ENZYME nomenclature database: 2.1.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.29
            BRENDA, the Enzyme Database: 2.1.1.29
///
ENTRY       EC 2.1.1.30
NAME        Deleted entry
            tRNA (purine-2- or -6-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
COMMENT     Deleted entry. Reactions previously described are due to
            EC 2.1.1.32.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.30
            ExPASy - ENZYME nomenclature database: 2.1.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.30
///
ENTRY       EC 2.1.1.31
NAME        tRNA (guanine-N1-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing N1-methylguanine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing N1-methylguanine
GENES       ECO: b2607(trmD)
            ECE: Z3901(trmD)
            ECS: ECs3470
            YPE: YPO3293(trmD)
            HIN: HI0202(trmD)
            PMU: PM1297(trmD)
            XFA: XF0109
            VCH: VC0563
            PAE: PA3743(trmD)
            BUC: BU396(trmD)
            NME: NMB0590
            NMA: NMA0793(trmD)
            HPY: HP1148(trmD)
            HPJ: jhp1075
            CJE: Cj0713(trmD)
            RPR: RP111(trmD)
            RCO: RC0151(trmD)
            MLO: mll4287
            SME: SMc03861(trmD)
            ATU: AGR_C_4898
            CCR: CC0198
            BSU: BG12687(trmD)
            BHA: BH2479(trmD)
            SAU: SA1083(trmD)
            SAV: SAV1227(trmD)
            LLA: L6128(trmD)
            SPY: SPy0849(trmD)
            SPN: SP0779
            SPR: spr0687(trmD)
            CAC: CAC1758(trmD)
            MGE: MG445(trmD)
            MPN: K05_orf210(trmD)
            MPU: MYPU_4680(trmD)
            UUR: UU567(trmD)
            MTU: Rv2906c(trmD)
            MTC: MT2974
            MLE: ML1615(trmD)
            CTR: CT027
            CMU: TC0296
            CPN: CPn0117
            CPA: CP0656
            CPJ: trmD
            BBU: BB0698(trmD)
            TPA: TP0908
            SYN: sll1198(trmD)
            DRA: DR2011
            AAE: aq_1489(trmD)
            TMA: TM1569
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.31
            ExPASy - ENZYME nomenclature database: 2.1.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.31
            BRENDA, the Enzyme Database: 2.1.1.31
///
ENTRY       EC 2.1.1.32
NAME        tRNA (guanine-N2-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing N2-methylguanine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing N2-methylguanine
COMMENT     In eukaryotic tRNAs two N2-guanine methylations occur, at the
            N2-methylguanine at position 10 and the N2-methylguanine at
            position 29.
GENES       AAE: aq_841(trm1)
            MJA: MJ0946(trm1)
            MTH: MTH1190
            AFU: AF0815(trm1)
            HAL: VNG2088G(trm1)
            TAC: Ta0997
            TVO: TVG0752240
            PHO: PH1829
            PAB: PAB2092
            APE: APE0782
            SSO: SSO0943
            STO: ST1269
            SCE: YDR120C(TRM1)
            SPO: TRM1(trm1)
            CEL: ZC376.5
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.32
            ExPASy - ENZYME nomenclature database: 2.1.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.32
            BRENDA, the Enzyme Database: 2.1.1.32
///
ENTRY       EC 2.1.1.33
NAME        tRNA (guanine-N7-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing N7-methylguanine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing N7-methylguanine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.33
            ExPASy - ENZYME nomenclature database: 2.1.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.33
            BRENDA, the Enzyme Database: 2.1.1.33
///
ENTRY       EC 2.1.1.34
NAME        tRNA (guanosine-2'-O-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA(Tyr) = S-Adenosyl-L-homocysteine +
            tRNA(Tyr) containing 2'-O-methylguanosine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA(Tyr)
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA(Tyr) containing 2'-O-methylguanosine
COMMENT     Methylates the 2'-hydroxy group of a guanosine present in a CG
            sequence.
GENES       ECO: b3651(trmH)
            ECE: Z5077(spoU)
            ECS: ECs4526
            YPE: YPO0037(trmH)
            LLA: L0330(trmH)
            SPR: spr1311(trmH)
            DRA: DR2211
            AAE: aq_1661(spoU)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.34
            ExPASy - ENZYME nomenclature database: 2.1.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.34
            BRENDA, the Enzyme Database: 2.1.1.34
///
ENTRY       EC 2.1.1.35
NAME        tRNA (uracil-5-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing thymine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing thymine
GENES       ECO: b3965(trmA)
            ECE: Z5526(trmA)
            ECS: ECs4896
            YPE: YPO3911(trmA)
            HIN: HI0848(trmA)
            PMU: PM1803(trmA)
            VCH: VC0154
            PAE: PA4720(trmA)
            NME: NMB1679
            NMA: NMA1938(trmA)
            CJE: Cj0831c(trmA)
MOTIF       PS: PS01230  [DN]-P-[PA]-R-x-G-x(14,16)-[LIVM](2)-Y-x-S-C-N-x(2)-T
            PS: PS01231  [LIVMF]-D-x-F-P-[QHY]-[ST]-x-H-[LIVMFY]-E
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.35
            ExPASy - ENZYME nomenclature database: 2.1.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.35
            BRENDA, the Enzyme Database: 2.1.1.35
///
ENTRY       EC 2.1.1.36
NAME        tRNA (adenine-N1-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing N1-methyladenine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing N1-methyladenine
COMMENT     The enzymes from different sources are specific for different
            adenine residues in tRNA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.36
            ExPASy - ENZYME nomenclature database: 2.1.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.36
            BRENDA, the Enzyme Database: 2.1.1.36
///
ENTRY       EC 2.1.1.37
NAME        DNA (cytosine-5-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + DNA = S-Adenosyl-L-homocysteine +
            DNA containing 5-methylcytosine
SUBSTRATE   S-Adenosyl-L-methionine
            DNA
PRODUCT     S-Adenosyl-L-homocysteine
            DNA containing 5-methylcytosine
PATHWAY     PATH: MAP00271  Methionine metabolism
GENES       ATH: At4g08990(F23J3.20)
            MMU: 94912(Dnmt)
            HSA: 1786(DNMT1)
DISEASE     MIM: 126375  DNA methyltransferase 1
MOTIF       PS: PS00094  [DENKS]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x(2)-[FYWLIM]-S
            PS: PS00095  [RKQGTF]-x(2)-G-N-[STAG]-[LIVMF]-x(3)-[LIVMT]-x(3)-
                         [LIVM]-x(3)-[LIVM]
STRUCTURES  PDB: 1HMY  1G55  1DCT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.37
            ExPASy - ENZYME nomenclature database: 2.1.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.37
            BRENDA, the Enzyme Database: 2.1.1.37
            SCOP (Structural Classification of Proteins): 2.1.1.37
///
ENTRY       EC 2.1.1.38
NAME        O-Demethylpuromycin O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase
REACTION    S-Adenosyl-L-methionine + O-Demethylpuromycin =
            S-Adenosyl-L-homocysteine + Puromycin
SUBSTRATE   S-Adenosyl-L-methionine
            O-Demethylpuromycin
PRODUCT     S-Adenosyl-L-homocysteine
            Puromycin
COMMENT     Puromycin is the antibiotic derived from N6-dimethyladenosine
            by replacing the 3'-hydroxyl group with an amino group
            and acylating this with 4-O-methyltyrosine.
PATHWAY     PATH: MAP00231  Puromycin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.38
            ExPASy - ENZYME nomenclature database: 2.1.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.38
            BRENDA, the Enzyme Database: 2.1.1.38
///
ENTRY       EC 2.1.1.39
NAME        myo-Inositol 1-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:myo-inositol 1-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + myo-Inositol =
            S-Adenosyl-L-homocysteine + 1D-1-O-Methyl-myo-inositol
SUBSTRATE   S-Adenosyl-L-methionine
            myo-Inositol
PRODUCT     S-Adenosyl-L-homocysteine
            1D-1-O-Methyl-myo-inositol
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.39
            ExPASy - ENZYME nomenclature database: 2.1.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.39
            BRENDA, the Enzyme Database: 2.1.1.39
///
ENTRY       EC 2.1.1.40
NAME        myo-Inositol 3-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:myo-inositol 3-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + myo-Inositol =
            S-Adenosyl-L-homocysteine + 1D-3-O-Methyl-myo-inositol
SUBSTRATE   S-Adenosyl-L-methionine
            myo-Inositol
PRODUCT     S-Adenosyl-L-homocysteine
            1D-3-O-Methyl-myo-inositol
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.40
            ExPASy - ENZYME nomenclature database: 2.1.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.40
            BRENDA, the Enzyme Database: 2.1.1.40
///
ENTRY       EC 2.1.1.41
NAME        24-Sterol C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:zymosterol C-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5alpha-Cholesta-8,24-dien-3beta-ol =
            S-Adenosyl-L-homocysteine +
            24-Methylene-5alpha-cholest-8-en-3beta-ol
SUBSTRATE   S-Adenosyl-L-methionine
            5alpha-Cholesta-8,24-dien-3beta-ol
PRODUCT     S-Adenosyl-L-homocysteine
            24-Methylene-5alpha-cholest-8-en-3beta-ol
COFACTOR    Glutathione
COMMENT     Requires glutathione.
GENES       SCE: YML008C(ERG6)
            SPO: SPBC16E9.05(spbc16e9.05)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.41
            ExPASy - ENZYME nomenclature database: 2.1.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.41
            BRENDA, the Enzyme Database: 2.1.1.41
///
ENTRY       EC 2.1.1.42
NAME        Luteolin O-methyltransferase
            O-Dihydric phenol methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone
            $ 3'-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5,7,3',4'-Tetrahydroxyflavone =
            S-Adenosyl-L-homocysteine + 5,7,4'-Trihydroxy-3'-methoxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            5,7,3',4'-Tetrahydroxyflavone
            Luteolin 7-O-beta-D-glucoside
PRODUCT     S-Adenosyl-L-homocysteine
            5,7,4'-Trihydroxy-3'-methoxyflavone
COMMENT     Also acts on luteolin 7-O-beta-D-glucoside
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.42
            ExPASy - ENZYME nomenclature database: 2.1.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.42
            BRENDA, the Enzyme Database: 2.1.1.42
///
ENTRY       EC 2.1.1.43
NAME        Histone-lysine N-methyltransferase
            Protein methylase III
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
REACTION    S-Adenosyl-L-methionine + Histone-L-lysine =
            S-Adenosyl-L-homocysteine + Histone N6-methyl-L-lysine
SUBSTRATE   S-Adenosyl-L-methionine
            Histone-L-lysine
PRODUCT     S-Adenosyl-L-homocysteine
            Histone N6-methyl-L-lysine
COMMENT     One of a group of enzymes methylationg proteins; see also
            EC 2.1.1.59 and 2.1.1.60.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.43
            ExPASy - ENZYME nomenclature database: 2.1.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.43
            BRENDA, the Enzyme Database: 2.1.1.43
///
ENTRY       EC 2.1.1.44
NAME        Dimethylhistidine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine
            $ Nalpha-methyltransferase
REACTION    S-Adenosyl-L-methionine + Nalpha,Nalpha-Dimethyl-L-histidine =
            S-Adenosyl-L-homocysteine +
            Nalpha,Nalpha,Nalpha-Trimethyl-L-histidine
SUBSTRATE   S-Adenosyl-L-methionine
            Nalpha,Nalpha-Dimethyl-L-histidine
            Nalpha-Methylhistidine
            Histidine
PRODUCT     S-Adenosyl-L-homocysteine
            Nalpha,Nalpha,Nalpha-Trimethyl-L-histidine
COMMENT     Methylhistidine and histidine can also act as methyl acceptors,
            trimethylhistidine being formed in both cases.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.44
            ExPASy - ENZYME nomenclature database: 2.1.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.44
            BRENDA, the Enzyme Database: 2.1.1.44
///
ENTRY       EC 2.1.1.45
NAME        Thymidylate synthase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
REACTION    5,10-Methylenetetrahydrofolate + dUMP = Dihydrofolate + dTMP
SUBSTRATE   5,10-Methylenetetrahydrofolate
            dUMP
PRODUCT     Dihydrofolate
            dTMP
INHIBITOR   5-fluorodeoxyuridine monophosphate
COMMENT     Cys-198 (L.casei) is the nucleophile that transiently adds to the
            6-position of dUMP during catalysis.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2827(thyA)
            ECE: Z4144(thyA)
            ECS: ECs3684
            YPE: YPO0783(thyA)
            HIN: HI0905(thyA)
            PMU: PM0079(thyA)
            XFA: XF2332
            VCH: VC0675
            PAE: PA0342(thyA)
            BUC: BU440(thyA)
            NME: NMB1709
            NMA: NMA1963(thyA)
            MLO: mll1467
            SME: SMc01444(thyA)
            CCR: CC2124
            BSU: BG10794(thyB) BG11190(thyA)
            BHA: BH3451(thyB)
            SAU: SA1260(thyA)
            SAV: SAV1415(thyA)
            LLA: L182559(thyA)
            SPY: SPy0882(thyA)
            SPN: SP0669
            SPR: spr0585(thyA)
            CAC: CAC3003(thyA)
            MGE: MG227(thyA)
            MPN: F10_orf328(thyA)
            MPU: MYPU_5380(thyA)
            MTU: Rv2764c(thyA)
            MTC: MT2834
            MLE: ML1519(thyA)
            TPA: TP1007
            DRA: DR2630
            MJA: MJ0511(thyA)
            MTH: MTH774
            AFU: AF2047
            SCE: YOR074C(CDC21)
            ATH: At2g16370(F16F14.13) At4g34570(T4L20.150)
            DME: CG3181
            MMU: 98878(Tyms)
            HSA: 7298(TYMS)
DISEASE     MIM: 188350  Thymidylate synthase
MOTIF       PS: PS00075  [LVAGC]-[LIF]-G-x(4)-[LIVMF]-P-W-x(4,5)-[DE]-x(3)-
                         [FYIV]-x(3)-[STIQ]
            PS: PS00091  R-x(2)-[LIVM]-x(3)-[FW]-[QN]-x(8,9)-[LV]-x-P-C-[HAVM]-
                         x(3)-[QMT]-[FYW]-x-[LV]
STRUCTURES  PDB: 1BQ2  1THY  1AIQ  1AJM  1AN5  1AOB  1AXW  1B02  1BDU  1BID  
                 1BJG  1BKO  1BKP  1BO7  1BO8  1BP0  1BP6  1BPJ  1BQ1  1NJE  
                 1BSF  1BSP  1CI7  1DDU  1DNA  1EV5  1EV8  1EVF  1EVG  1F28  
                 1F4B  1F4C  1F4D  1F4E  1F4F  1F4G  1FFL  1HVY  1HW3  1HW4  
                 1HZW  1I00  1JMF  1JMG  1JMH  1JMI  1JTQ  1JTU  1JU6  1JUJ  
                 1JUT  1KCE  1LCA  1LCB  1LCE  1NJA  1NJB  1NJC  1NJD  1TIS  
                 1QQQ  1RTS  1SYN  1TDA  1TDB  1TDC  1TDU  1VZC  2BBQ  1TJS  
                 1TLC  1TLS  1TRG  1TSD  1TSL  1TSM  1TSN  1TSV  1TSW  1TSX  
                 1TSY  1TSZ  1TVU  1TVV  1TVW  1TYS  1VZA  1VZB  1VZE  1VZD  
                 4TMS  1ZPR  3TMS  2KCE  2TDD  2TDM  2TSC  2TSR  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.45
            ExPASy - ENZYME nomenclature database: 2.1.1.45
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.45
            BRENDA, the Enzyme Database: 2.1.1.45
            SCOP (Structural Classification of Proteins): 2.1.1.45
///
ENTRY       EC 2.1.1.46
NAME        Isoflavone 4'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:isoflavone 4-O'-methyltransferase
REACTION    S-Adenosyl-L-methionine + Isoflavone = S-Adenosyl-L-homocysteine
            + 4'-O-Methylisoflavone
SUBSTRATE   S-Adenosyl-L-methionine
            Isoflavone
PRODUCT     S-Adenosyl-L-homocysteine
            4'-O-Methylisoflavone
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.46
            ExPASy - ENZYME nomenclature database: 2.1.1.46
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.46
            BRENDA, the Enzyme Database: 2.1.1.46
///
ENTRY       EC 2.1.1.47
NAME        Indolepyruvate C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:indolepyruvate C-methyltransferase
REACTION    S-Adenosyl-L-methionine + Indolepyruvate =
            S-Adenosyl-L-homocysteine + (S)-beta-Methylindolepyruvate
SUBSTRATE   S-Adenosyl-L-methionine
            Indolepyruvate
PRODUCT     S-Adenosyl-L-homocysteine
            (S)-beta-Methylindolepyruvate
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.47
            ExPASy - ENZYME nomenclature database: 2.1.1.47
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.47
            BRENDA, the Enzyme Database: 2.1.1.47
///
ENTRY       EC 2.1.1.48
NAME        rRNA (adenine-N6-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + rRNA = S-Adenosyl-L-homocysteine +
            rRNA containing N6-methyladenine
SUBSTRATE   S-Adenosyl-L-methionine
            2-Aminoadenosine
            rRNA
PRODUCT     S-Adenosyl-L-homocysteine
            2-Methylaminoadenosine
            rRNA containing N6-methyladenine
COMMENT     Also methylates 2-aminoadenosine to 2-methylaminoadenosine.
GENES       NME: NMB0066
            BHA: BH0380
            SAU: SA0048(ermA) SA0766(ermA) SA1480(ermA) SA1951(ermA)
                 SA2384(ermA)
            SAV: SAV0047(ermA) SAV1639(ermA)
            AAE: aq_262
            AFU: AF2194
MOTIF       PS: PS01131  [LIVM]-[LIVMFY]-[DE]-x-G-[STAPV]-G-x-[GA]-x-[LIVMF]-
                         [ST]-x(2)-[LIVM]-x(6)-[LIVMY]-x-[STAGV]-[LIVMFYHC]-E-x-
                         D
STRUCTURES  PDB: 1QAN  2ERC  1QAM  1YUB  1QAO  1QAQ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.48
            ExPASy - ENZYME nomenclature database: 2.1.1.48
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.48
            BRENDA, the Enzyme Database: 2.1.1.48
            SCOP (Structural Classification of Proteins): 2.1.1.48
///
ENTRY       EC 2.1.1.49
NAME        Amine N-methyltransferase
            Nicotine N-methyltransferase
            Tryptamine N-methyltransferase
            Arylamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:amine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + an Amine = S-Adenosyl-L-homocysteine +
            a Methylated amine
SUBSTRATE   S-Adenosyl-L-methionine
            Amine
            Tryptamine
            Aniline
            Nicotine
PRODUCT     S-Adenosyl-L-homocysteine
            Methylated amine
COMMENT     An enzyme of very broad specificity; many primary, secondary and
            tertiary amines can act as acceptors, including tryptamine,
            anilinem nicotine and a variety of drugs and other xenobiotics.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.49
            ExPASy - ENZYME nomenclature database: 2.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.49
            BRENDA, the Enzyme Database: 2.1.1.49
///
ENTRY       EC 2.1.1.50
NAME        Loganate O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:loganate 11-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Loganate = S-Adenosyl-L-homocysteine +
            Loganin
SUBSTRATE   S-Adenosyl-L-methionine
            Loganate
            Secologanate
PRODUCT     S-Adenosyl-L-homocysteine
            Loganin
COMMENT     Also acts on secologanate.  Methylates the 11-carboxy group of the
            monoterpenoid loganate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.50
            ExPASy - ENZYME nomenclature database: 2.1.1.50
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.50
            BRENDA, the Enzyme Database: 2.1.1.50
///
ENTRY       EC 2.1.1.51
NAME        rRNA (guanine-N1-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + rRNA = S-Adenosyl-L-homocysteine +
            rRNA containing N1-methylguanine
SUBSTRATE   S-Adenosyl-L-methionine
            rRNA
PRODUCT     S-Adenosyl-L-homocysteine
            rRNA containing N1-methylguanine
GENES       ECO: b1822(rrmA)
            ECE: Z2866(yebH)
            ECS: ECs2532
            YPE: YPO1748(rrmA)
            VCH: VC2003
            PAE: PA1161(rrmA)
            SPN: SP2103
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.51
            ExPASy - ENZYME nomenclature database: 2.1.1.51
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.51
            BRENDA, the Enzyme Database: 2.1.1.51
///
ENTRY       EC 2.1.1.52
NAME        rRNA (guanine-N2-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + rRNA = S-Adenosyl-L-homocysteine +
            rRNA containing N2-methylguanine
SUBSTRATE   S-Adenosyl-L-methionine
            rRNA
PRODUCT     S-Adenosyl-L-homocysteine
            rRNA containing N2-methylguanine
GENES       ECO: b4371(yjjT)
            YPE: YPO0427(rsmC)
            HIN: HI0012
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.52
            ExPASy - ENZYME nomenclature database: 2.1.1.52
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.52
            BRENDA, the Enzyme Database: 2.1.1.52
///
ENTRY       EC 2.1.1.53
NAME        Putrescine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:putrescine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Putrescine =
            S-Adenosyl-L-homocysteine + N-Methylputrescine
SUBSTRATE   S-Adenosyl-L-methionine
            Putrescine
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylputrescine
PATHWAY     PATH: MAP00960  Alkaloid biosynthesis II
MOTIF       PS: PS01330  V-[LA]-[LIV](2)-G-G-G-x-G-x(2)-[LIV]-x-E
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.53
            ExPASy - ENZYME nomenclature database: 2.1.1.53
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.53
            BRENDA, the Enzyme Database: 2.1.1.53
///
ENTRY       EC 2.1.1.54
NAME        Deoxycytidylate C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5,10-Methylenetetrahydrofolate:dCMP C-methyltransferase
REACTION    5,10-Methylenetetrahydrofolate + dCMP = Dihydrofolate +
            Deoxy-5-methylcytidylate
SUBSTRATE   5,10-Methylenetetrahydrofolate
            dCMP
PRODUCT     Dihydrofolate
            Deoxy-5-methylcytidylate
COMMENT     dCMP is methylated by formaldehyde in the presence of
            tetrahydrofolate.  CMP, dCTP and CTP can act as acceptors, more
            slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.54
            ExPASy - ENZYME nomenclature database: 2.1.1.54
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.54
            BRENDA, the Enzyme Database: 2.1.1.54
///
ENTRY       EC 2.1.1.55
NAME        tRNA (adenine-N6-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing N6-methyladenine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing N6-methyladenine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.55
            ExPASy - ENZYME nomenclature database: 2.1.1.55
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.55
            BRENDA, the Enzyme Database: 2.1.1.55
///
ENTRY       EC 2.1.1.56
NAME        mRNA (guanine-N7-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + G(5')pppR-RNA =
            S-Adenosyl-L-homocysteine +
            m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
SUBSTRATE   S-Adenosyl-L-methionine
            G(5')pppR-RNA
PRODUCT     S-Adenosyl-L-homocysteine
            m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
COMMENT     R may be guanosine or adenosine.
GENES       DME: CG3688(l(2)35Bd)
STRUCTURES  PDB: 1IC3  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.56
            ExPASy - ENZYME nomenclature database: 2.1.1.56
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.56
            BRENDA, the Enzyme Database: 2.1.1.56
///
ENTRY       EC 2.1.1.57
NAME        mRNA (nucleoside-2'-O-)-methyltransferase
            mRNA (adenosine-2'-O-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + m7G(5')pppR-RNA =
            S-Adenosyl-L-homocysteine +
            m7G(5')pppRm-RNA (mRNA containing an 2'-O-methylpurine cap)
SUBSTRATE   S-Adenosyl-L-methionine
            m7G(5')pppR-RNA
PRODUCT     S-Adenosyl-L-homocysteine
            m7G(5')pppRm-RNA (mRNA containing an 2'-O-methylpurine cap)
COMMENT     In the reaction given, R may be guanosine or adenosine.  The
            formation of a 2'-O-methyladenosine cap was formerly listed as
            EC 2.1.1.58.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.57
            ExPASy - ENZYME nomenclature database: 2.1.1.57
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.57
            BRENDA, the Enzyme Database: 2.1.1.57
///
ENTRY       EC 2.1.1.58
NAME        Deleted entry
            mRNA (adenosine-2'-O-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
COMMENT     Deleted entry. Now included with EC 2.1.1.57.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.58
            ExPASy - ENZYME nomenclature database: 2.1.1.58
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.58
///
ENTRY       EC 2.1.1.59
NAME        Cytochrome-c-lysine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase
REACTION    S-Adenosyl-L-methionine + Cytochrome c L-lysine =
            S-Adenosyl-L-homocysteine + Cytochrome c N6-methyl-L-lysine
SUBSTRATE   S-Adenosyl-L-methionine
            Cytochrome c L-lysine
PRODUCT     S-Adenosyl-L-homocysteine
            Cytochrome c N6-methyl-L-lysine
COMMENT     One of a group of enzymes methylating proteins; see also
            EC 2.1.1.43 and 2.1.1.60.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.59
            ExPASy - ENZYME nomenclature database: 2.1.1.59
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.59
            BRENDA, the Enzyme Database: 2.1.1.59
///
ENTRY       EC 2.1.1.60
NAME        Calmodulin-lysine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase
REACTION    S-Adenosyl-L-methionine + Calmodulin L-lysine =
            S-Adenosyl-L-homocysteine + Calmodulin N6-methyl-L-lysine
SUBSTRATE   S-Adenosyl-L-methionine
            Calmodulin L-lysine
PRODUCT     S-Adenosyl-L-homocysteine
            Calmodulin N6-methyl-L-lysine
COMMENT     One of a group of enzymes methylating proteins; see also
            EC 2.1.1.43 and 2.1.1.59.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.60
            ExPASy - ENZYME nomenclature database: 2.1.1.60
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.60
            BRENDA, the Enzyme Database: 2.1.1.60
///
ENTRY       EC 2.1.1.61
NAME        tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:tRNA
            $(5-methylaminomethyl-2-thiouridylate)-methyltransferase
REACTION    S-Adenosyl-L-methionine + tRNA = S-Adenosyl-L-homocysteine +
            tRNA containing 5-methylaminomethyl-2-thiouridylate
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA
PRODUCT     S-Adenosyl-L-homocysteine
            tRNA containing 5-methylaminomethyl-2-thiouridylate
COMMENT     This enzyme is specific for the terminal methyl group of
            5-methylaminomethyl-2-thiouridylate
GENES       ECO: b1133(trmU)
            ECE: Z1862(ycfB)
            ECS: ECs1605
            YPE: YPO1638(trmU)
            HIN: HI0174
            PMU: PM1336
            XFA: XF1440
            VCH: VC1128
            PAE: PA2626(trmU)
            BUC: BU261(trmU)
            NME: NMB1556
            NMA: NMA1744(trmU)
            HPY: HP1335
            HPJ: jhp1254
            CJE: Cj0053c(trmU)
            RPR: RP306
            RCO: RC0410(trmU)
            MLO: mlr2824
            SME: SMc00659(trmU)
            CCR: CC0897
            BSU: BG13787(trmU)
            BHA: BH1261
            SAU: SA1449
            SAV: SAV1609
            LLA: L52034(trmU)
            SPY: SPy2188
            SPN: SP0118
            SPR: spr0122(trmU)
            CAC: CAC2233
            MGE: MG295
            MPN: A05_orf370
            MPU: MYPU_5580(trmU)
            UUR: UU402(trmU)
            MTU: Rv3024c
            MTC: MT3108
            MLE: ML1707
            CTR: CT287
            CMU: TC0560
            CPN: CPn0438
            CPA: CP0315
            CPJ: ycbF
            BBU: BB0682
            SYN: sll0844
            DRA: DR1759
            AAE: aq_1224
            TMA: TM0520
            SCE: YDL033C(YDL033C)
            SPO: SPAC23H4.04(spac23h4.04)
            CEL: B0035.16
            DME: CG3021
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.61
            ExPASy - ENZYME nomenclature database: 2.1.1.61
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.61
            BRENDA, the Enzyme Database: 2.1.1.61
///
ENTRY       EC 2.1.1.62
NAME        mRNA (2'-O-methyladenosine-N6-)-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:mRNA
            $(2'-O-methyladenosine-N6-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + m7G(5')pppAm =
            S-Adenosyl-L-homocysteine +
            m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap)
SUBSTRATE   S-Adenosyl-L-methionine
            m7G(5')pppAm
PRODUCT     S-Adenosyl-L-homocysteine
            m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.62
            ExPASy - ENZYME nomenclature database: 2.1.1.62
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.62
            BRENDA, the Enzyme Database: 2.1.1.62
///
ENTRY       EC 2.1.1.63
NAME        Methylated-DNA--protein-cysteine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase
REACTION    DNA containing 6-O-methylguanine + Protein cysteine = DNA +
            Protein S-methyl-L-cysteine
SUBSTRATE   DNA containing 6-O-methylguanine
            Protein cysteine
PRODUCT     DNA
            Protein S-methyl-L-cysteine
COMMENT     This enzyme is involved in the repair of alkylated DNA in E. coli
            and the enzyme acts only on the alkylated DNA as an adaptive
            response to alkylating agants. cf. EC 3.2.2.20 and 3.2.2.21.
GENES       ECO: b1335(ogt) b2213(ADA)
            ECE: Z2432(ogt) Z3471(ada)
            ECS: ECs1916 ECs3102
            YPE: YPO0072 YPO2299(ogt)
            HIN: HI0402(ogt)
            PMU: PM1068(dat1)
            XFA: XF2598
            VCH: VCA1017
            PAE: PA0995(ogt) PA2118(ada)
            NME: NMB1528
            NMA: NMA1728
            HPY: HP0676(dat1)
            HPJ: jhp0618
            CJE: Cj0836(ogt)
            RCO: RC0870(dat)
            MLO: mlr1858 mlr3180
            SME: SMb20708 SMc02841
            CCR: CC0659 CC0689 CC3729
            BSU: BG10167(adaB) BG10848(ogt)
            BHA: BH0393(adaB) BH1021(dat)
            SAU: SA2335(adaB)
            SAV: SAV2530(adaB)
            LLA: L118481(ogt)
            SPN: SP1463
            SPR: spr1317(ogt)
            CAC: CAC3261(ada)
            MPU: MYPU_0950(ogt)
            MTU: Rv1316c(ogt) Rv1317c(alkA)
            MTC: MT1357 MT1358
            MLE: ML1151(ogt)
            CTR: CT477
            CPN: CPn0596
            CPA: CP0152
            CPJ: ada
            TPA: TP0141
            AAE: aq_1495(ogt)
            TMA: TM0887
            MJA: MJ1529(ogt)
            MTH: MTH618
            AFU: AF2314(ogt)
            PHO: PH1835
            PAB: PAB0260(ogt)
            APE: APE0959
            SSO: SSO2487(ogt)
            STO: ST0967
            SCE: YDL200C(MGT1)
            DME: CG1303(agt)
            MMU: 96977(Mgmt)
            HSA: 4255(MGMT)
DISEASE     MIM: 156569  Methylguanine-DNA methyltransferase
MOTIF       PS: PS00041  [KRQ]-[LIVMA]-x(2)-[GSTALIV]-{FYWPGDN}-x(2)-[LIVMSA]-
                         x(4,9)-[LIVMF]-x(2)-[LIVMSTA]-[GSTACIL]-x(3)-[GANQRF]-
                         [LIVMFY]-x(4,5)-[LFY]-x(3)-[FYIVA]-{FYWHCM}-x(3)-
                         [GSADENQKR]-x-[NSTAPKL]-[PARL]
            PS: PS00374  [LIVMF]-P-C-H-R-[LIVMF](2)
            PS: PS01124  Bacterial regulatory proteins, araC family DNA-
                         binding domain profile
STRUCTURES  PDB: 1SFE  1EH6  1EH7  1EH8  1MGT  1QNT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.63
            ExPASy - ENZYME nomenclature database: 2.1.1.63
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.63
            BRENDA, the Enzyme Database: 2.1.1.63
            SCOP (Structural Classification of Proteins): 2.1.1.63
///
ENTRY       EC 2.1.1.64
NAME        3-Demethylubiquinone-9 3-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-
            $methoxy-1,4-benzoquinone 3-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3-Demethylubiquinone-9 =
            S-Adenosyl-L-homocysteine + Ubiquinone-9
SUBSTRATE   S-Adenosyl-L-methionine
            3-Demethylubiquinone-9
PRODUCT     S-Adenosyl-L-homocysteine
            Ubiquinone-9
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b2232(ubiG)
            ECE: Z3486(ubiG)
            ECS: ECs3115
            YPE: YPO1215(ubiG)
            PMU: PM0840(ubiG)
            XFA: XF2471
            VCH: VC1257
            PAE: PA3171(ubiG)
            NME: NMB2030
            NMA: NMA0410(ubiG)
            RPR: RP622(ubiG)
            MLO: mlr3442
            SME: SMc02440(ubiG)
            CCR: CC0840
            DRA: DR2562
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.64
            ExPASy - ENZYME nomenclature database: 2.1.1.64
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.64
            BRENDA, the Enzyme Database: 2.1.1.64
///
ENTRY       EC 2.1.1.65
NAME        Licodione 2'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:licodione 2'-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Licodione =
            S-Adenosyl-L-homocysteine + 2'-O-Methyllicodione
SUBSTRATE   S-Adenosyl-L-methionine
            Licodione
PRODUCT     S-Adenosyl-L-homocysteine
            2'-O-Methyllicodione
COMMENT     As well as licodione (1-(2,4-dihydroxyphenyl)-3-4-hydroxyphenyl)-
            -1,3-propanedione), the 2'-hydroxy-derivative and
            isoliquiritigenin can act as acceptors, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.65
            ExPASy - ENZYME nomenclature database: 2.1.1.65
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.65
            BRENDA, the Enzyme Database: 2.1.1.65
///
ENTRY       EC 2.1.1.66
NAME        rRNA (adenosine-2'-O-)-methyltransferase
            RNA-pentose methylase
            Thiostrepton-resistance methylase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:rRNA (adenosine-2'-O-)-methyltransferase
REACTION    S-Adenosyl-L-methionine + rRNA = S-Adenosyl-L-homocysteine +
            rRNA containing a single residue of 2'-O-methyladenosine
SUBSTRATE   S-Adenosyl-L-methionine
            rRNA
PRODUCT     S-Adenosyl-L-homocysteine
            rRNA containing a single residue of 2'-O-methyladenosine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.66
            ExPASy - ENZYME nomenclature database: 2.1.1.66
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.66
            BRENDA, the Enzyme Database: 2.1.1.66
///
ENTRY       EC 2.1.1.67
NAME        Thiopurine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:thiopurine S-methyltransferase
REACTION    S-Adenosyl-L-methionine + a Thiopurine =
            S-Adenosyl-L-homocysteine + a Thiopurine S-methylether
SUBSTRATE   S-Adenosyl-L-methionine
            Thiopurine
PRODUCT     S-Adenosyl-L-homocysteine
            Thiopurine S-methylether
COMMENT     Also acts, more slowly, on thiopyrimidines and aromatic thiols.
            Not identical with EC 2.1.1.9.
GENES       VCH: VC1226
            PAE: PA2832(tpm)
            MMU: 98812(Tpmt)
            HSA: 7172(TPMT)
DISEASE     MIM: 187680  Thiopurine S-methyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.67
            ExPASy - ENZYME nomenclature database: 2.1.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.67
            BRENDA, the Enzyme Database: 2.1.1.67
///
ENTRY       EC 2.1.1.68
NAME        Caffeate O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate
            $ 3-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3,4-Dihydroxy-trans-cinnamate =
            S-Adenosyl-L-homocysteine + 3-Methoxy-4-hydroxy-trans-cinnamate
SUBSTRATE   S-Adenosyl-L-methionine
            3,4-Dihydroxy-trans-cinnamate
PRODUCT     S-Adenosyl-L-homocysteine
            3-Methoxy-4-hydroxy-trans-cinnamate
COMMENT     3,4-Dihydroxybenzaldehyde and catechol can act as acceptors, more
            slowly.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.68
            ExPASy - ENZYME nomenclature database: 2.1.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.68
            BRENDA, the Enzyme Database: 2.1.1.68
///
ENTRY       EC 2.1.1.69
NAME        5-Hydroxyfuranocoumarin 5-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:5-hydroxyfuranocoumarin
            $ 5-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5-Hydroxyfuranocoumarin =
            S-Adenosyl-L-homocysteine + 5-Methoxyfuranocoumarin
SUBSTRATE   S-Adenosyl-L-methionine
            5-Hydroxyfuranocoumarin
            Bergaptol
PRODUCT     S-Adenosyl-L-homocysteine
            5-Methoxyfuranocoumarin
            Bergapten
COMMENT     Converts bergaptol into bergapten.  Methylates the 5-hydroxyl of
            some hydroxy- and methylcoumarins, but has little activity on
            non-coumarin phenol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.69
            ExPASy - ENZYME nomenclature database: 2.1.1.69
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.69
            BRENDA, the Enzyme Database: 2.1.1.69
///
ENTRY       EC 2.1.1.70
NAME        8-Hydroxyfuranocoumarin 8-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:8-hydroxyfuranocoumarin
            $ 8-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 8-Hydroxyfuranocoumarin =
            S-Adenosyl-L-homocysteine + 8-Methoxyfuranocoumarin
SUBSTRATE   S-Adenosyl-L-methionine
            8-Hydroxyfuranocoumarin
            Xanthotoxol
PRODUCT     S-Adenosyl-L-homocysteine
            8-Methoxyfuranocoumarin
            Xanthotoxin
COMMENT     Converts xanthotoxol into xanthotoxin.  Methylates the 8-hydroxyl
            of some hydroxy- and methylcoumarins, but has little activity on
            non-coumarin phenol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.70
            ExPASy - ENZYME nomenclature database: 2.1.1.70
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.70
            BRENDA, the Enzyme Database: 2.1.1.70
///
ENTRY       EC 2.1.1.71
NAME        Phosphatidyl-N-methylethanolamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:phosphatidyl-N-methylethanolamine
            $ N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Phosphatidyl-N-methylethanolamine =
            S-Adenosyl-L-homocysteine + Phosphatidyl-N-dimethylethanolamine
SUBSTRATE   S-Adenosyl-L-methionine
            Phosphatidyl-N-methylethanolamine
PRODUCT     S-Adenosyl-L-homocysteine
            Phosphatidyl-N-dimethylethanolamine
COMMENT     The enzyme also catalyses the transfer of a further methyl group,
            producing phosphatidylcholine.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.71
            ExPASy - ENZYME nomenclature database: 2.1.1.71
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.71
            BRENDA, the Enzyme Database: 2.1.1.71
///
ENTRY       EC 2.1.1.72
NAME        Site-specific DNA-methyltransferase (adenine-specific)
            Modification methylase
            Restriction-Modification system
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + DNA adenine = S-Adenosyl-L-homocysteine
            + DNA 6-methylaminopurine
SUBSTRATE   S-Adenosyl-L-methionine
            DNA adenine
PRODUCT     S-Adenosyl-L-homocysteine
            DNA 6-methylaminopurine
COMMENT     This is a large group of enzymes most of which, with enzymes of
            similar site specificity listed as EC 3.1.21.3, 4 or 5, form so-
            -called 'restriction-modification systems'. A complelte listing of
            all the these enzymes has been produced by R.J.Roberts; this list
            is update annually.
GENES       ECO: b2330(yfcB) b3262(yhdJ) b3387(dam) b4349(hsdM)
            ECE: Z3593(yfcB) Z4622(yhdJ) Z4740(dam)
            ECS: ECs3215 ECs4134 ECs4229
            YPE: YPO0154(dam)
            HIN: HI0209(dam) HI0215(hsdM) HI0513(hinDIIM) HI1201 HI1287(hsdM)
                 HI1392(hinDIIIM)
            PMU: PM0390 PM0698 PM1222(dam) PM1537(hsdM)
            XFA: XF1368 XF2723 XF2724 XF2728 XF2742
            VCH: VC1769 VC2118 VC2626
            PAE: PA1678 PA2735
            NME: NMB0829 NMB1655
            NMA: NMA0059 NMA0191 NMA1038 NMA1912
            HPY: HP0050(dpnA) HP0054 HP0092(hsdM) HP0263(hpaim) HP0463(hsdM)
                 HP0478(VSPIM) HP0481(MFOKI) HP0593(mod) HP0850(hsdM)
                 HP0910(HINDIIM) HP1208 HP1352(HINFIM) HP1367 HP1370(mod)
                 HP1403(hsdM) HP1472(mod) HP1517(ECO57IR)
            HPJ: jhp0043 jhp0415 jhp0430 jhp0433 jhp0786 jhp1271 jhp1411
                 jhp1423
            CJE: Cj0208 Cj1553c
            MLO: mlr7520
            SME: SMc00021(ccrM) SMc02296(hsdM)
            CCR: CC0378 CC0620
            SAU: SA0391(hsdM) SA1626
            SAV: SAV0420 SAV1794
            LLA: L0309(hsdM)
            SPY: SPy1906(hsdM)
            SPN: SP0886
            SPR: spr0790(hsdM)
            MGE: MG184
            MPN: GT9_orf319(mte1) H91_orf543(hsdM)
            MPU: MYPU_0810(hsdM) MYPU_0820(hsdM) MYPU_3960 MYPU_3970 MYPU_3980
                 MYPU_4330(hsdM) MYPU_4800 MYPU_6780(hsdM)
            UUR: UU098(hsdM-1) UU100(hsdM-2)
            MTU: Rv2756c
            MTC: MT2826
            TPA: TP0810
            SYN: slr1803(mbpA)
            MJA: MJ0132 MJ0598 MJ1220 MJ1328 MJ1498 MJECL42
            MTH: MTH942
            HAL: VNG0106G(rmeM)
            TAC: Ta0644 Ta1168
            TVO: TVG0884813
            PHO: PH1032
            PAB: PAB2149
MOTIF       PS: PS00092  [LIVMAC]-[LIVFYWA]-x-[DN]-P-P-[FYW]
STRUCTURES  PDB: 2ADM  1G38  2DPM  1AQI  1AQJ  1EG2  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.72
            ExPASy - ENZYME nomenclature database: 2.1.1.72
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.72
            BRENDA, the Enzyme Database: 2.1.1.72
            SCOP (Structural Classification of Proteins): 2.1.1.72
///
ENTRY       EC 2.1.1.73
NAME        Site-specific DNA-methyltransferase (cytosine-specific )
            Modification methylase
            Restriction-Modification system
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + DNA cytosine = S-Adenosyl-L-homocysteine
            + DNA 5-methylcytosine
SUBSTRATE   S-Adenosyl-L-methionine
            DNA cytosine
            Deoxycytosine
PRODUCT     S-Adenosyl-L-homocysteine
            DNA 5-methylcytosine
            5-Methyl-2'-deoxycytidine
COMMENT     This is a large group of enzymes which, with enzymes of similar
            site specificity listed as EC 3.1.21.3, 4 or 5, form so-called
            "restriction-modification systems". A complelte listing of all
            the these enzymes has been produced by R.J.Roberts; this list is
            update annually.
GENES       ECO: b1961(dcm)
            ECE: Z2389 Z3054(dcm)
            ECS: ECs2699
            HIN: HI1041
            NME: NMB0725 NMB0826 NMB1033 NMB1290
            NMA: NMA0193 NMA0427 NMA1035(nmgII) NMA1453 NMA1500
            HPY: HP0051(DDEM) HP0054 HP1121(BSP6IM)
            HPJ: jhp0435 jhp1050
            SME: SMc03763
            CCR: CC1033
            BSU: BG12627(mtbP)
            BHA: BH3508
            SPN: SP1336
            CAC: CAC1222
            MPU: MYPU_0430 MYPU_0440 MYPU_1850 MYPU_1860
            UUR: UU528(dcm)
            SYN: slr0214
            AAE: aq_644
            MJA: MJ0563 MJ1200
            MTH: MTH495
            PHO: PH0039
            PAB: PAB2317
            APE: APE0872 APE2002
            SSO: SSO0265
            STO: ST0335
MOTIF       PS: PS00094  [DENKS]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x(2)-[FYWLIM]-S
            PS: PS00095  [RKQGTF]-x(2)-G-N-[STAG]-[LIVMF]-x(3)-[LIVMT]-x(3)-
                         [LIVM]-x(3)-[LIVM]
STRUCTURES  PDB: 8MHT  4MHT  5MHT  10MH  1FJX  1MHT  2HMY  3MHT  6MHT  7MHT  
                 9MHT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.73
            ExPASy - ENZYME nomenclature database: 2.1.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.73
            BRENDA, the Enzyme Database: 2.1.1.73
            SCOP (Structural Classification of Proteins): 2.1.1.73
///
ENTRY       EC 2.1.1.74
NAME        Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase
            $ (FADH(2)-oxidizing)
            Folate-dependent ribothymidyl synthase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5,10-Methylenetetrahydrofolate:tRNA-UpsiC (uracil-5-)-
            $ methyltransferase
REACTION    5,10-Methylenetetrahydrofolate + tRNA UpsiC + FADH2 =
            Tetrahydrofolate + tRNA TpsiC + FAD
SUBSTRATE   5,10-Methylenetetrahydrofolate
            tRNA UpsiC
            FADH2
PRODUCT     Tetrahydrofolate
            tRNA TpsiC
            FAD
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.74
            ExPASy - ENZYME nomenclature database: 2.1.1.74
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.74
            BRENDA, the Enzyme Database: 2.1.1.74
///
ENTRY       EC 2.1.1.75
NAME        Apigenin 4'-O-methyltransferase
            Flavonoid O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:5,7,4'-trihydroxyflavone
            $ 4'-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5,7,4'-Trihydroxyflavone =
            S-Adenosyl-L-homocysteine + 4'-Methoxy-5,7-dihydroxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            5,7,4'-Trihydroxyflavone
            Naringenin
PRODUCT     S-Adenosyl-L-homocysteine
            Acacetin
            4'-Methoxy-5,7-dihydroxyflavonone
COMMENT     Converts apigenin into acacetin.  Naringenin (5,7,4'-trihydroxy-
            flavanone) can also act as acceptor, more slowly.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.75
            ExPASy - ENZYME nomenclature database: 2.1.1.75
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.75
            BRENDA, the Enzyme Database: 2.1.1.75
///
ENTRY       EC 2.1.1.76
NAME        Quercetin 3-O-methyltransferase
            Flavonol 3-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyfavone
            $ 3-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3,5,7,3',4'-Pentahydroxyflavone =
            S-Adenosyl-L-homocysteine +
            3-Methoxy-5,7,3',4'-tetrahydroxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            3,5,7,3',4'-Pentahydroxyflavone
PRODUCT     S-Adenosyl-L-homocysteine
            3-Methoxy-5,7,3',4'-tetrahydroxyflavone
COMMENT     Specific for quercetin.  Related enzymes bring about the
            3-O-methylation of other flavonols, such as galangin and
            kaempferol.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.76
            ExPASy - ENZYME nomenclature database: 2.1.1.76
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.76
            BRENDA, the Enzyme Database: 2.1.1.76
///
ENTRY       EC 2.1.1.77
NAME        Protein-L-isoaspartate(D-aspartate) O-methyltransferase
            Protein-L-isoaspartate O-methyltransferase
            Protein-beta-aspartate methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Protein L-isoaspartate =
            S-Adenosyl-L-homocysteine + Protein L-isoaspartate methyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Protein L-isoaspartate
PRODUCT     S-Adenosyl-L-homocysteine
            Protein L-isoaspartate methyl ester
COMMENT     D-Aspartate (but not L-aspartate) residues in proteins can also
            act as acceptor. Previously also listed as EC 2.1.1.24.
GENES       ECO: b2743(pcm)
            ECE: Z4051(pcm)
            YPE: YPO3357(pcm)
            XFA: XF0857 XF2585
            VCH: VC0532
            PAE: PA3624(pcm)
            NME: NMB1885
            NMA: NMA0572
            HPY: HP0363(pcm)
            HPJ: jhp1017
            CJE: Cj0228c(pcm)
            MLO: mll1078 mll1108 mll2628
            SME: SMa1547 SMc02062(pcm)
            CCR: CC1997
            MTU: Rv2118c
            MTC: MT2178
            MLE: ML1313
            AAE: aq_311
            TMA: TM0704 TM0748
            MJA: MJ0134 MJ0172(pcm)
            MTH: MTH1414 MTH827
            AFU: AF0036(pcm-1) AF0216 AF2322(pcm-2)
            HAL: VNG0089G(pimT1)
            TAC: Ta0852
            TVO: TVG1006378
            PHO: PH1858 PH1886
            PAB: PAB0283(pimT-like) PAB1206(pcm)
            APE: APE1011 APE2486
            SSO: SSO0427 SSO2599(pcm)
            STO: ST0182 ST0370 ST1123
            SPO: SPAC869.08(spac869.08)
            CEL: pcm-1
            DME: CG2152(Pcmt)
            MMU: 97502(Pcmt1)
            HSA: 5110(PCMT1)
DISEASE     MIM: 176851  Protein-L-isoaspartate (D-aspartate)
                         O-methyltransferase
MOTIF       PS: PS01279  [GSA]-D-G-x(2)-G-[FYWLV]-x(3)-[GSA]-[PT]-[FY]-[DNSH]-x-
                         I
STRUCTURES  PDB: 1DL5  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.77
            ExPASy - ENZYME nomenclature database: 2.1.1.77
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.77
            BRENDA, the Enzyme Database: 2.1.1.77
            SCOP (Structural Classification of Proteins): 2.1.1.77
///
ENTRY       EC 2.1.1.78
NAME        Isoorientin 3'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:isoorientin 3'-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Isoorientin = S-Adenosyl-L-homocysteine
            + Isocoparin
SUBSTRATE   S-Adenosyl-L-methionine
            Isoorientin
            Isoorientin 2''-O-rhamnoside
PRODUCT     S-Adenosyl-L-homocysteine
            Isocoparin
COMMENT     Also acts on isoorientin 2''-O-rhamnoside.  Involved in the
            biosynthesis of flavones.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.78
            ExPASy - ENZYME nomenclature database: 2.1.1.78
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.78
            BRENDA, the Enzyme Database: 2.1.1.78
///
ENTRY       EC 2.1.1.79
NAME        Cyclopropane-fatty-acyl-phospholipid synthase
            Cyclopropane synthetase
            Unsaturated-phospholipid methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:unsaturated-phospholipid methyltransferase
            $ (cyclizing)
REACTION    S-Adenosyl-L-methionine + Phospholipid olefinic fatty acid =
            S-Adenosyl-L-homocysteine +
            Phospholipid cyclopropane fatty acid
SUBSTRATE   S-Adenosyl-L-methionine
            Phospholipid olefinic fatty acid
PRODUCT     S-Adenosyl-L-homocysteine
            Phospholipid cyclopropane fatty acid
COMMENT     The enzyme adds a methylene group across the 9,10 position of a
            delta9-olefinic acyl chain in phosphatidylethanolamine or, more
            slowly, phosphatidylglycerol or phosphatidylinositol forming a
            cyclopropane deirvative (cf. EC 2.1.1.16).
GENES       ECO: b1661(CFA)
            ECE: Z2686(cfa)
            ECS: ECs2370
            YPE: YPO2390(cfa)
            VCH: VC1122
            PAE: PA5546
            HPY: HP0416(cfa)
            HPJ: jhp0968
            CJE: Cj1183c(cfa)
            MLO: mll0368 mll4091 mll7842
            SME: SMc00358(cfa1) SMc02645(cfa2)
            CCR: CC1427
            CAC: CAC0877(cfa)
            MTU: Rv0447c(ufaA1) Rv0469(umaA1) Rv0470c(umaA2) Rv0503c(cmaA2)
                 Rv0642c(mmaA4) Rv0643c(mmaA3) Rv0644c(mmaA2) Rv0645c(mmaA1)
                 Rv3392c(cmaA1) Rv3720
            MTC: MT0463 MT0486 MT0524 MT0670 MT0671 MT0672 MT0673 MT3499
                 MT3823
            MLE: ML1900(mmaA1) ML1903(mmaA4) ML2334 ML2426(cmaA2)
                 ML2459(umaA2)
            DRA: DR2187
            AAE: aq_1737(cfa)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.79
            ExPASy - ENZYME nomenclature database: 2.1.1.79
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.79
            BRENDA, the Enzyme Database: 2.1.1.79
///
ENTRY       EC 2.1.1.80
NAME        Protein-glutamate O-methyltransferase
            Methyl-accepting chemotaxis protein O-methyltrnasferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:protein-L-glutamate O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Protein glutamate =
            S-Adenosyl-L-homocysteine + Protein glutamate methyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Protein glutamate
PRODUCT     S-Adenosyl-L-homocysteine
            Protein glutamate methyl ester
COMMENT     Forms ester groups with L-glutamate residues in a number of
            membrane proteins.
            Entry A32449 is temporally moved from EC 2.1.1.24.
GENES       ECO: b1884(cheR)
            ECE: Z2938(cheR)
            ECS: ECs2594
            YPE: YPO1678(cheR)
            VCH: VC1399 VCA1091
            PAE: PA0175 PA3348
            CJE: Cj0923c(cheR)
            SME: SMc03009(cheR)
            CCR: CC0435 CC0598
            BSU: BG10283(cheR)
            BHA: BH1655(cheR)
            CAC: CAC0121(cheR) CAC2221(cheR)
            BBU: BB0040(cheR-1) BB0414(cheR-2)
            TPA: TP0630
            AAE: aq_1776
            TMA: TM0464
            AFU: AF1037(cheR)
            PHO: PH0481
            PAB: PAB1329(cheR)
STRUCTURES  PDB: 1BC5  1AF7  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.80
            ExPASy - ENZYME nomenclature database: 2.1.1.80
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.80
            BRENDA, the Enzyme Database: 2.1.1.80
            SCOP (Structural Classification of Proteins): 2.1.1.80
///
ENTRY       EC 2.1.1.81
NAME        Deleted entry
            Nicotine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
COMMENT     Deleted entry. Now included with EC 2.1.1.49.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.81
            ExPASy - ENZYME nomenclature database: 2.1.1.81
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.81
///
ENTRY       EC 2.1.1.82
NAME        3-Methylquercetin 7-O-methyltransferase
            Flavonol 7-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone
            $ 7-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3',4',5,7-Tetrahydroxy-3-methoxyflavone
            S-Adenosyl-L-homocysteine +
            3',4',5-Trihydroxy-3,7-dimethoxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            3',4',5,7-Tetrahydroxy-3-methoxyflavone
PRODUCT     S-Adenosyl-L-homocysteine
            3',4',5-Trihydroxy-3,7-dimethoxyflavone
COMMENT     Involved with EC 2.1.1.76 and 2.1.1.83 in the methylation of
            quercitin to 3,7,4'-trimethylquercitin in Chrysosplenium
            americanum.  Does not act on flavones, dihydroflavonols, or their
            glucosides.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.82
            ExPASy - ENZYME nomenclature database: 2.1.1.82
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.82
            BRENDA, the Enzyme Database: 2.1.1.82
///
ENTRY       EC 2.1.1.83
NAME        3,7-Dimethylquercetin 4'-O-methyltransferase
            Flavonol 4'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone
            $ 4'-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3',4',5-Trihydroxy-3,7-dimethoxyflavone = 
            S-Adenosyl-L-homocysteine + 3',5-Dihydroxy-3,4',7-trimethoxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            3',4',5-Trihydroxy-3,7-dimethoxyflavone
PRODUCT     S-Adenosyl-L-homocysteine
            3',5-Dihydroxy-3,4',7-trimethoxyflavone
COMMENT     3,7-Dimethylquercetagetin can also act as acceptor.  Involved with
            EC 2.1.1.76 and 2.1.1.82 in the methylation of quercitin to
            3,7,4'-trimethylquercitin in Chrysosplenium americanum.  Does not
            act on flavones, dihydroflavonols, or their glucosides.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.83
            ExPASy - ENZYME nomenclature database: 2.1.1.83
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.83
            BRENDA, the Enzyme Database: 2.1.1.83
///
ENTRY       EC 2.1.1.84
NAME        Methylquercetagetin 6-O-methyltransferase
            Flavonol 6-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-
            $dimethoxyflavone 6-O-methyltransferase
REACTION    S-Adenosyl-L-methionine +
            3',4',5,6-Tetrahydroxy-3,7-dimethoxyflavone =
            S-Adenosyl-L-homocysteine +
            3',4',5-Trihydroxy-3,6,7-trimethoxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            3',4',5,6-Tetrahydroxy-3,7-dimethoxyflavone
PRODUCT     S-Adenosyl-L-homocysteine
            3',4',5-Trihydroxy-3,6,7-trimethoxyflavone
COMMENT     Also methylates 3,7,3'-trimethylquercetagetin at the 6-position.
            Does not act on flavones, dihydroflavonols, or their glucosides.
            From Chrysosplenium americanum.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.84
            ExPASy - ENZYME nomenclature database: 2.1.1.84
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.84
            BRENDA, the Enzyme Database: 2.1.1.84
///
ENTRY       EC 2.1.1.85
NAME        Protein-histidine N-methyltransferase
            Protein methylase IV
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:protein-L-histidine
            $ N-tele-methyltransferase
REACTION    S-Adenosyl-L-methionine + Protein histidine =
            S-Adenosyl-L-homocysteine + Protein Ntau-methyl-L-histidine
SUBSTRATE   S-Adenosyl-L-methionine
            Protein histidine
PRODUCT     S-Adenosyl-L-homocysteine
            Protein Ntau-methyl-L-histidine
COMMENT     Highly specific for histidine residues, for example in actin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.85
            ExPASy - ENZYME nomenclature database: 2.1.1.85
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.85
            BRENDA, the Enzyme Database: 2.1.1.85
///
ENTRY       EC 2.1.1.86
NAME        Tetrahydromethanopterin S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     5-Methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate
            $ 2-methyltransferas
REACTION    5-Methyl-5,6,7,8-tetrahydromethanopterin +
            2-Mercaptoethanesulfonate = 5,6,7,8-Tetrahydromethanopterin +
            2-(Methylthio)ethanesulfonate
SUBSTRATE   5-Methyl-5,6,7,8-tetrahydromethanopterin
            2-Mercaptoethanesulfonate
PRODUCT     5,6,7,8-Tetrahydromethanopterin
            2-(Methylthio)ethanesulfonate
COMMENT     Involved in the formation of methane from CO in Methanobacterium
            thermoautotrophicum.  Methanopterin is a pterin analogue.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       MJA: MJ0847(mtrE) MJ0848(mtrD) MJ0849(mtrC) MJ0850(mtrB)
                 MJ0851(mtrA) MJ0852(mtrF) MJ0853(mtrG) MJ0854(mtrH)
            MTH: MTH1062 MTH1156(mtrH) MTH1157(mtrG) MTH1158(mtrF)
                 MTH1159(mtrA) MTH1160(mtrB) MTH1161(mtrC) MTH1162(mtrD)
                 MTH1163(mtrE)
            AFU: AF0009(mtr)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.86
            ExPASy - ENZYME nomenclature database: 2.1.1.86
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.86
            UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.86
            BRENDA, the Enzyme Database: 2.1.1.86
///
ENTRY       EC 2.1.1.87
NAME        Pyridine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:pyridine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Pyridine = S-Adenosyl-L-homocysteine +
            N-Methylpyridinium
SUBSTRATE   S-Adenosyl-L-methionine
            Pyridine
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylpyridinium
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.87
            ExPASy - ENZYME nomenclature database: 2.1.1.87
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.87
            BRENDA, the Enzyme Database: 2.1.1.87
///
ENTRY       EC 2.1.1.88
NAME        8-Hydroxyquercetin 8-O-methyltransferase
            Flavonol 8-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone
            $ 8-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3,3',4',5,7,8-Hexahydroxyflavone =
            S-Adenosyl-L-homocysteine +
            3,3',4',5,7-Pentahydroxy-8-methoxyflavone
SUBSTRATE   S-Adenosyl-L-methionine
            3,3',4',5,7,8-Hexahydroxyflavone
            8-Hydroxykaempferol
PRODUCT     S-Adenosyl-L-homocysteine
            3,3',4',5,7-Pentahydroxy-8-methoxyflavone
COMMENT     Also acts on 8-hydroxykaempferol, but not on the glycosides of
            8-hydroxyflavonols.  An enzyme form the flower buds of Lotus
            corniculatus.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.88
            ExPASy - ENZYME nomenclature database: 2.1.1.88
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.88
            BRENDA, the Enzyme Database: 2.1.1.88
///
ENTRY       EC 2.1.1.89
NAME        Tetrahydrocolumbamine 2-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine
            $ 2-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 5,8,13,13a-Tetrahydrocolumbamine =
            S-Adenosyl-L-homocysteine + Tetrahydropalmatine
SUBSTRATE   S-Adenosyl-L-methionine
            5,8,13,13a-Tetrahydrocolumbamine
PRODUCT     S-Adenosyl-L-homocysteine
            Tetrahydropalmatine
COMMENT     Involved in the biosynthesis of the berberine alkaloids.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.89
            ExPASy - ENZYME nomenclature database: 2.1.1.89
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.89
            BRENDA, the Enzyme Database: 2.1.1.89
///
ENTRY       EC 2.1.1.90
NAME        Methanol--5-hydroxybenzimidazolylcobamide Co-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     Methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
REACTION    Methanol + 5-Hydroxybenzimidazolylcobamide =
            Co-Methyl-Co-5-hydroxybenzimidazolylcob(I)amide + H2O
SUBSTRATE   Methanol
            5-Hydroxybenzimidazolylcobamide
PRODUCT     Co-Methyl-Co-5-hydroxybenzimidazolylcob(I)amide
            H2O
COMMENT     The enzyme form Methanosarcina barkeri contains 3-4 molecules of
            bound 5-hydroxybenzimidazolylcobamide which act as methyl
            acceptor.  Inactivated by oxygen and other oxidizing agents, and
            reactivated by catalytic amounts of ATP and hydrogen.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.90
            ExPASy - ENZYME nomenclature database: 2.1.1.90
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.90
            BRENDA, the Enzyme Database: 2.1.1.90
///
ENTRY       EC 2.1.1.91
NAME        Isobutyraldoxime O-methyltransferase
            Aldoxime methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 2-Methylpropanal oxime =
            S-Adenosyl-L-homocysteine + 2-Methylpropanal O-methyloxime
SUBSTRATE   S-Adenosyl-L-methionine
            2-Methylpropanal oxime
PRODUCT     S-Adenosyl-L-homocysteine
            2-Methylpropanal O-methyloxime
COMMENT     Oximes of C4 to C6 aldehydes can act as acceptors; the most active
            substrate is 2-methylbutyroaldoxime.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.91
            ExPASy - ENZYME nomenclature database: 2.1.1.91
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.91
            BRENDA, the Enzyme Database: 2.1.1.91
///
ENTRY       EC 2.1.1.92
NAME        Bergaptol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:bergaptol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Bergaptol = S-Adenosyl-L-homocysteine +
            O-Methylbergaptol
SUBSTRATE   S-Adenosyl-L-methionine
            Bergaptol
PRODUCT     S-Adenosyl-L-homocysteine
            O-Methylbergaptol
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.92
            ExPASy - ENZYME nomenclature database: 2.1.1.92
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.92
            BRENDA, the Enzyme Database: 2.1.1.92
///
ENTRY       EC 2.1.1.93
NAME        Xanthotoxol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:xanthotoxol O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Xanthotoxol =
            S-Adenosyl-L-homocysteine + O-Methylxanthotoxol
SUBSTRATE   S-Adenosyl-L-methionine
            Xanthotoxol
            5-Hydroxyxanthotoxin
PRODUCT     S-Adenosyl-L-homocysteine
            O-Methylxanthotoxol
            Isopimpinellin
COMMENT     Also acts on 5-hydroxyxanthotoxin, forming isopimpinellin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.93
            ExPASy - ENZYME nomenclature database: 2.1.1.93
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.93
            BRENDA, the Enzyme Database: 2.1.1.93
///
ENTRY       EC 2.1.1.94
NAME        11-O-Demethyl-17-O-deacetylvindoline O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline
            $ 11-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 11-O-Demethyl-17-O-deacetylvindoline =
            S-Adenosyl-L-homocysteine + 17-O-Deacetylvindoline
SUBSTRATE   S-Adenosyl-L-methionine
            11-O-Demethyl-17-O-deacetylvindoline
PRODUCT     S-Adenosyl-L-homocysteine
            17-O-Deacetylvindoline
COMMENT     Involved in the biosynthesis of vindoline from tabersonine in
            Catharanthus roseus.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.94
            ExPASy - ENZYME nomenclature database: 2.1.1.94
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.94
            BRENDA, the Enzyme Database: 2.1.1.94
///
ENTRY       EC 2.1.1.95
NAME        Tocopherol O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + gamma-Tocopherol =
            S-Adenosyl-L-homocysteine + alpha-Tocopherol
SUBSTRATE   S-Adenosyl-L-methionine
            gamma-Tocopherol
PRODUCT     S-Adenosyl-L-homocysteine
            alpha-Tocopherol
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.95
            ExPASy - ENZYME nomenclature database: 2.1.1.95
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.95
            BRENDA, the Enzyme Database: 2.1.1.95
///
ENTRY       EC 2.1.1.96
NAME        Thioether S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase
REACTION    S-Adenosyl-L-methionine + Dimethyl sulfide =
            S-Adenosyl-L-homocysteine + Trimethylsulfonium
SUBSTRATE   S-Adenosyl-L-methionine
            Dimethyl sulfide
            Dimethyl selenide
            Dimethyl telluride
            Diethyl sulfide
            1,4-Dithiane
PRODUCT     S-Adenosyl-L-homocysteine
            Trimethylsulfonium
COMMENT     Also acts on dimethyl selenide, dimethyl telluride, diethyl
            sulfide, 1,4-dithiane and many other thioethers.
MOTIF       PS: PS01100  L-I-D-I-G-S-G-P-T-[IV]-Y-Q-[LV]-L-[SA]-A-C
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.96
            ExPASy - ENZYME nomenclature database: 2.1.1.96
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.96
            BRENDA, the Enzyme Database: 2.1.1.96
///
ENTRY       EC 2.1.1.97
NAME        3-Hydroxyanthranilate 4-C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:3-hydroxyanthranilate
            $ 4-C-methyltransferase
REACTION    S-Adenosyl-L-methionine + 3-Hydroxyanthranilate =
            S-Adenosyl-L-homocysteine + 3-Hydroxy-4-methylanthranilate
SUBSTRATE   S-Adenosyl-L-methionine
            3-Hydroxyanthranilate
PRODUCT     S-Adenosyl-L-homocysteine
            3-Hydroxy-4-methylanthranilate
COMMENT     Involved in the biosynthesis of the antibiotic actinomycin in
            Streptomyces antibioticus.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.97
            ExPASy - ENZYME nomenclature database: 2.1.1.97
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.97
            BRENDA, the Enzyme Database: 2.1.1.97
///
ENTRY       EC 2.1.1.98
NAME        Diphthine synthase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine
            $ methyltransferase
REACTION    S-Adenosyl-L-methionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine = 
            S-Adenosyl-L-homocysteine + 
            2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine
SUBSTRATE   S-Adenosyl-L-methionine
            2-(3-Carboxy-3-aminopropyl)-L-histidine
PRODUCT     S-Adenosyl-L-homocysteine
            2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine
COMMENT     2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine and the
            corresponding dimethyl compound can also act as acceptors; the
            trimethylated product, diphthine, is converted into diphthamide by
            EC 6.3.2.22.
GENES       MJA: MJ1274(dph5)
            MTH: MTH1874
            AFU: AF0381(dph5)
            HAL: VNG1118G(lds)
            TAC: Ta0883
            TVO: TVG1034064
            PHO: PH0725
            PAB: PAB1501(dph5)
            APE: APE0931
            SSO: SSO0953
            STO: ST1278
            SCE: YLR172C(DPH5)
            SPO: SPCC576.14(spcc576.14)
            CEL: B0491.7
            DME: CG5275(Dph5)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.98
            ExPASy - ENZYME nomenclature database: 2.1.1.98
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.98
            BRENDA, the Enzyme Database: 2.1.1.98
///
ENTRY       EC 2.1.1.99
NAME        16-Methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:
            $16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase1
REACTION    S-Adenosyl-L-methionine +
            16-Methoxy-2,3-dihydro-3-hydroxytabersonine =
            S-Adenosyl-L-homocysteine + Deacetoxyvindoline
SUBSTRATE   S-Adenosyl-L-methionine
            16-Methoxy-2,3-dihydro-3-hydroxytabersonine
PRODUCT     S-Adenosyl-L-homocysteine
            Deacetoxyvindoline
COMMENT     Involved in the biosynthesis of vindoline from tabersonine in
            Catharanthus roseus.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.99
            ExPASy - ENZYME nomenclature database: 2.1.1.99
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.99
            BRENDA, the Enzyme Database: 2.1.1.99
///
ENTRY       EC 2.1.1.100
NAME        Protein-S-isoprenylsysteine O-methyltransferase
            Isoprenylcysteine carboxylmethyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine
            $ O-methyltransferase
REACTION    S-Adenosyl-L-methionine +
            Protein C-terminal S-farnesyl-L-cysteine =
            S-Adenosyl-L-homocysteine +
            Protein C-terminal S-farnesyl-L-cysteine methyl ester
SUBSTRATE   S-Adenosyl-L-methionine
            Protein C-terminal S-farnesyl-L-cysteine
PRODUCT     S-Adenosyl-L-homocysteine
            Protein C-terminal S-farnesyl-L-cysteine methyl ester
COMMENT     C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues
            are also methylated, more slowly.
GENES       SCE: YDR410C(STE14)
            SPO: MAM4(mam4)
            HSA: 23463(ICMT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.100
            ExPASy - ENZYME nomenclature database: 2.1.1.100
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.100
            BRENDA, the Enzyme Database: 2.1.1.100
///
ENTRY       EC 2.1.1.101
NAME        Macrocin O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:macrocin 3'''-O-methyltransferas
REACTION    S-Adenosyl-L-methionine + Macrocin = S-Adenosyl-L-homocysteine +
            Tylosin
SUBSTRATE   S-Adenosyl-L-methionine
            Macrocin
            Lactenosin
PRODUCT     S-Adenosyl-L-homocysteine
            Tylosin
            Desmycocin
COMMENT     The 3-hydroxy group of a 2-O-methyl-6-deoxy-D-allose reisidue in
            the macrolide antibiotic macrosin acts as methyl acceptor; also
            converts lactenosin into desmycocin.  Not identical with
            EC 2.1.1.102.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.101
            ExPASy - ENZYME nomenclature database: 2.1.1.101
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.101
            BRENDA, the Enzyme Database: 2.1.1.101
///
ENTRY       EC 2.1.1.102
NAME        Demethylmacrocin O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Demethylmacrocin =
            S-Adenosyl-L-homocysteine + Macrocin
SUBSTRATE   S-Adenosyl-L-methionine
            Demethylmacrocin
PRODUCT     S-Adenosyl-L-homocysteine
            Macrocin
COMMENT     The 2-hydroxyl group of a 6-deoxy-D-allose residue in
            demethylmacrocin acts as methyl acceptor.  Not identical with
            Ec 2.1.1.101.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.102
            ExPASy - ENZYME nomenclature database: 2.1.1.102
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.102
            BRENDA, the Enzyme Database: 2.1.1.102
///
ENTRY       EC 2.1.1.103
NAME        Phosphoethanolamine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Ethanolamine phosphate =
            S-Adenosyl-L-homocysteine + N-Methylethanolamine phosphate
SUBSTRATE   S-Adenosyl-L-methionine
            Ethanolamine phosphate
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylethanolamine phosphate
COMMENT     The enzyme may catalyse the transfer of two further methyl groups
            to the product.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.103
            ExPASy - ENZYME nomenclature database: 2.1.1.103
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.103
            BRENDA, the Enzyme Database: 2.1.1.103
///
ENTRY       EC 2.1.1.104
NAME        Caffeoyl-CoA O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Caffeoyl-CoA = S-Adenosyl-L-homocysteine
            + Feruloyl-CoA
SUBSTRATE   S-Adenosyl-L-methionine
            Caffeoyl-CoA
PRODUCT     S-Adenosyl-L-homocysteine
            Feruloyl-CoA
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.104
            ExPASy - ENZYME nomenclature database: 2.1.1.104
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.104
            BRENDA, the Enzyme Database: 2.1.1.104
///
ENTRY       EC 2.1.1.105
NAME        N-Benzoyl-4-hydroxyanthranilate 4-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate
            $ 4-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + N-Benzoyl-4-hydroxyanthranilate =
            S-Adenosyl-L-homocysteine + N-Benzoyl-4-O-methoxyanthranilate
SUBSTRATE   S-Adenosyl-L-methionine
            N-Benzoyl-4-hydroxyanthranilate
PRODUCT     S-Adenosyl-L-homocysteine
            N-Benzoyl-4-O-methoxyanthranilate
COMMENT     Involved in the biosynthesis of phytoalexins.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.105
            ExPASy - ENZYME nomenclature database: 2.1.1.105
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.105
            BRENDA, the Enzyme Database: 2.1.1.105
///
ENTRY       EC 2.1.1.106
NAME        Tryptophan 2-C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase
REACTION    S-Adenosyl-L-methionine + L-Tryptophan =
            S-Adenosyl-L-homocysteine + L-2-Methyltryptophan
SUBSTRATE   S-Adenosyl-L-methionine
            L-Tryptophan
PRODUCT     S-Adenosyl-L-homocysteine
            L-2-Methyltryptophan
COMMENT     D-Tryptophan and indolepyruvate can also act as acceptors, more
            slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.106
            ExPASy - ENZYME nomenclature database: 2.1.1.106
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.106
            BRENDA, the Enzyme Database: 2.1.1.106
///
ENTRY       EC 2.1.1.107
NAME        Uroporphyrin-III C-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
REACTION    S-Adenosyl-L-methionine + Uroporphyrin III =
            S-Adenosyl-L-homocysteine + Sirohydrochlorin
SUBSTRATE   S-Adenosyl-L-methionine
            Uroporphyrin III
PRODUCT     S-Adenosyl-L-homocysteine
            Sirohydrochlorin
COMMENT     Involved in the biosynthesis of siroheme and cobalamin.
GENES       ECO: b3803(hemX)
            ECE: Z5317(hemX)
            ECS: ECs4733
            HIN: HI0602.1 HI0603(hemX)
            PMU: PM1814
            XFA: XF1798
            VCH: VC0118 VC2561
            PAE: PA0510 PA1778(cobA) PA5258
            NME: NMB0778
            NMA: NMA0989
            MLO: mlr1386
            SME: SMb20987 SMc04284(cobA)
            CCR: CC0618 CC1118
            BSU: BG11098(nasF) BG13380(ylnD)
            BHA: BH1495
            SAU: SA2186(nasF)
            SAV: SAV2382(nasF)
            CAC: CAC0098(hemD)
            MTU: Rv0511(cysG)
            MTC: MT0532
            MLE: ML2420(hemD)
            SYN: sll0166(hemD) sll0378(cysG)
            DRA: DRA0011
            AAE: aq_207(cobA)
            MJA: MJ0965(cobA)
            MTH: MTH167
            AFU: AF0422(cysG-1) AF1243(cysG-2)
            HAL: VNG2331G(uroM)
            TAC: Ta0653
            TVO: TVG0975318
            APE: APE0236
            SSO: SSO2435(cobA) SSO2908(cysG)
            STO: ST0563
            SCE: YKR069W(MET1)
            SPO: SPCC1739.06C(spcc1739.06c)
MOTIF       PS: PS00839  [LIVM]-[GS]-[STAL]-G-P-G-x(3)-[LIVMFY]-[LIVM]-T-[LIVM]-
                         [KRHQG]-[AG]
            PS: PS00840  V-x(2)-[LI]-x(2)-G-D-x(3)-[FYW]-[GS]-x(8)-[LIVF]-
                         x(5,6)-[LIVMFYWPAC]-x-[LIVMY]-x-P-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.107
            ExPASy - ENZYME nomenclature database: 2.1.1.107
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.107
            BRENDA, the Enzyme Database: 2.1.1.107
///
ENTRY       EC 2.1.1.108
NAME        6-Hydroxymellein O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 6-Hydroxymellein =
            S-Adenosyl-L-homocysteine + 6-Methoxymellein
SUBSTRATE   S-Adenosyl-L-methionine
            6-Hydroxymellein
            3,4-Dehydro-6-hydroxymellein
PRODUCT     S-Adenosyl-L-homocysteine
            6-Methoxymellein
COMMENT     3,4-Dehydro-6-hydroxymellein can also act as acceptor.
            6-Methoxymellein is a phytoalexin produced by carrot tissue.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.108
            ExPASy - ENZYME nomenclature database: 2.1.1.108
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.108
            BRENDA, the Enzyme Database: 2.1.1.108
///
ENTRY       EC 2.1.1.109
NAME        Demethylsterigmatocystin 6-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:6-demethylsterigmatocystin
            $ 6-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + 6-Demethylsterigmatocystin =
            S-Adenosyl-L-homocysteine + Sterigmatocystin
SUBSTRATE   S-Adenosyl-L-methionine
            6-Demethylsterigmatocystin
            Dihydromethylsterigmatocystin
PRODUCT     S-Adenosyl-L-homocysteine
            Sterigmatocystin
COMMENT     Dihydromethylsterigmatocystin can also act as acceptor.  Involved
            in the biosynthesis of aflatoxins in fungi.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.109
            ExPASy - ENZYME nomenclature database: 2.1.1.109
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.109
            BRENDA, the Enzyme Database: 2.1.1.109
///
ENTRY       EC 2.1.1.110
NAME        Sterigmatocystin 7-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Sterigmatocystin =
            S-Adenosyl-L-homocysteine + 7-O-Methylsterigmatocystin
SUBSTRATE   S-Adenosyl-L-methionine
            Sterigmatocystin
PRODUCT     S-Adenosyl-L-homocysteine
            7-O-Methylsterigmatocystin
COMMENT     Dihydrosterigmatocystin can also act as acceptor.  Involved in the
            biosynthesis of aflatoxins in fungi.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.110
            ExPASy - ENZYME nomenclature database: 2.1.1.110
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.110
            BRENDA, the Enzyme Database: 2.1.1.110
///
ENTRY       EC 2.1.1.111
NAME        Anthranilate N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:anthranilate N-methyltransferase
REACTION    S-Adenosyl-L-methionine + Anthranilate =
            S-Adenosyl-L-homocysteine + N-Methylanthranilate
SUBSTRATE   S-Adenosyl-L-methionine
            Anthranilate
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methylanthranilate
COMMENT     Involved in the biosynthesis of acridine alkaloids in plant
            tissues.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.111
            ExPASy - ENZYME nomenclature database: 2.1.1.111
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.111
            BRENDA, the Enzyme Database: 2.1.1.111
///
ENTRY       EC 2.1.1.112
NAME        Glucuronoxylan 4-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:glucuronoxylan-D-glucuronate
            $ 4-O-methyltransferase
REACTION    S-Adenosyl-L-methionine + Glucuronoxylan D-glucuronate =
            S-Adenosyl-L-homocysteine +
            Glucuronoxylan 4-O-methyl-D-glucuronate
SUBSTRATE   S-Adenosyl-L-methionine
            Glucuronoxylan D-glucuronate
PRODUCT     S-Adenosyl-L-homocysteine
            Glucuronoxylan 4-O-methyl-D-glucuronate
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.112
            ExPASy - ENZYME nomenclature database: 2.1.1.112
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.112
            BRENDA, the Enzyme Database: 2.1.1.112
///
ENTRY       EC 2.1.1.113
NAME        Site-specific DNA-methyltransferase (cytosine-N4-specific)
            Modification methylase
            Restriction-modification system
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
SYSNAME     S-Adenosyl-L-methionine:DNA-cytosine N-methyltransferase
REACTION    S-Adenosyl-L-methionine + DNA cytosine =
            S-Adenosyl-L-homocysteine + DNA N4-methylcytosine
SUBSTRATE   S-Adenosyl-L-methionine
            DNA cytosine
PRODUCT     S-Adenosyl-L-homocysteine
            DNA N4-methylcytosine
COMMENT     This is a large group of enzymes, the majority of which, with
            enzymes of similar specificity listed as EC 3.1.21.3, 4 and 5,
            form so-called 'restriction-modification systems',  A complete
            listing of all these enzymes has been produced by R.J. Roberts
            (4143); this list is upated annually.
            4143. Roberts, R.J.(1990) Nucleic Acids Res. 18, 2331 [2.1.1.73,
            2.1.1.74, 2.1.1.113, 3.1.21.3, 3.1.21.4, 3.1.21.5].
GENES       HPY: HP1368(mod)
            MJA: MJ0985 MJ1498
            HAL: VNG1543G(zim)
MOTIF       PS: PS00092  [LIVMAC]-[LIVFYWA]-x-[DN]-P-P-[FYW]
            PS: PS00093  [LIVMF]-T-S-P-P-[FY]
STRUCTURES  PDB: 1BOO  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.113
            ExPASy - ENZYME nomenclature database: 2.1.1.113
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.113
            BRENDA, the Enzyme Database: 2.1.1.113
            SCOP (Structural Classification of Proteins): 2.1.1.113
///
ENTRY       EC 2.1.1.114
NAME        Hexaprenyldihydroxybenzoate methyltransferase
            Dihydroxyhexaprenylbenzoate methyltransferase
            3,4-Dihydroxy-5-hexaprenylbenzoate methyltransferase
            DHHB methyltransferase
            DHHB-MT
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + 3-Hexaprenyl-4,5-dihydroxybenzoate =
            S-Adenosyl-L-homocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate
SUBSTRATE   S-Adenosyl-L-methionine
            3-Hexaprenyl-4,5-dihydroxybenzoate
PRODUCT     S-Adenosyl-L-homocysteine
            3-Hexaprenyl-4-hydroxy-5-methoxybenzoate
GENES       SCE: YOL096C(COQ3)
            SPO: SPCC162.05(spcc162.05)
            ATH: At2g30920(F7F1.13)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.114
            ExPASy - ENZYME nomenclature database: 2.1.1.114
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.114
///
ENTRY       EC 2.1.1.115
NAME        (R,S)-Tetrahydrobenzylisoquinoline N-methyltransferase
            Norreticuline N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + (R,S)-Tetrahydrobenzylisoquinoline =
            S-Adenosyl-L-homocysteine + N-Methyl-(R,S)-tetrahydrobenzyl
            $isoquinoline
SUBSTRATE   S-Adenosyl-L-methionine
            (R,S)-Tetrahydrobenzylisoquinoline
PRODUCT     S-Adenosyl-L-homocysteine
            N-Methyl-(R,S)-tetrahydrobenzylisoquinoline
COMMENT     Broad substrate specificity for (R,S)-Tetrahydrobenzylisoquinolines;
            Including Coclaurine, Norcoclaurine, Isococlaurine, Norarmepavine,
            Norreticuline and Tetrahydropapaverine.
            Both R- and S-enantiomers are methylated.
            Partcipates in the pathway leading to Benzylisoquinoline alkaloid
            synthesis in plants. The physiological substrate is likely to be
            Coclaurine.
            Was termed Norreticuline N-methyltransferase, however Norreticuline
            has not been found to cccur in nature and that name does not
            reflects the broad specificity of the enzyme.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.115
            ExPASy - ENZYME nomenclature database: 2.1.1.115
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.115
///
ENTRY       EC 2.1.1.116
NAME        3'-Hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + 3'-Hydroxy-N-methyl-(S)-coclaurine =
            S-Adenosyl-L-homocysteine + (S)-Reticuline
SUBSTRATE   S-Adenosyl-L-methionine
            3'-Hydroxy-N-methyl-(S)-coclaurine
PRODUCT     S-Adenosyl-L-homocysteine
            (S)-Reticuline
COMMENT     Involved in Isoquinoline alkaloid metabolism in plants.
            Has also been shown to catalyse the methylation of (R,S)-
            Laudanosoline, (S)-3'-Hysroxycoclaurine and (R,S)-7-O-
            Methylnoraudanosine.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.116
            ExPASy - ENZYME nomenclature database: 2.1.1.116
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.116
///
ENTRY       EC 2.1.1.117
NAME        (S)-Scoulerine 9-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + (S)-Scoulerine =
            S-Adenosyl-L-homocysteine + (S)-Tetrahydrocolumbamine
SUBSTRATE   S-Adenosyl-L-methionine
            (S)-Scoulerine
PRODUCT     S-Adenosyl-L-homocysteine
            (S)-Tetrahydrocolumbamine
COMMENT     The product of this reaction id a precursor for protoberberine
            alkanoids in plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.117
            ExPASy - ENZYME nomenclature database: 2.1.1.117
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.117
///
ENTRY       EC 2.1.1.118
NAME        Columbamine O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + Columbamine =
            S-Adenosyl-L-homocysteine + Palmatine
SUBSTRATE   S-Adenosyl-L-methionine
            Columbamine
PRODUCT     S-Adenosyl-L-homocysteine
            Palmatine
COMMENT     The product of this reaction is a protoberberine alkaloid that is
            widely distributed in the plant kingdom.
            Distinct in specificity from EC 2.1.1.88.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.118
            ExPASy - ENZYME nomenclature database: 2.1.1.118
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.118
///
ENTRY       EC 2.1.1.119
NAME        10-Dihydroxydihydrosanguinarine 10-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + 10-Hydroxydihydrosanguinarine =
            S-Adenosyl-L-homocysteine + Dihydrochelirubine
SUBSTRATE   S-Adenosyl-L-methionine
            10-Hydroxydihydrosanguinarine
PRODUCT     S-Adenosyl-L-homocysteine
            Dihydrochelirubine
COMMENT     Part of the pathway for synthesis of Benzophenanthridine alkanoids
            in plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.119
            ExPASy - ENZYME nomenclature database: 2.1.1.119
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.119
///
ENTRY       EC 2.1.1.120
NAME        12-Hydroxydihydrochelirubine 12-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + 12-Hydroxydihydrochelirubine =
            S-Adenosyl-L-homocysteine + Dihydromacarpine
SUBSTRATE   S-Adenosyl-L-methionine
            12-Hydroxydihydrochelirubine
PRODUCT     S-Adenosyl-L-homocysteine
            Dihydromacarpine
COMMENT     Part of the pathway for synthesis of Banzophenanthridine alkaloid
            Macarpine in plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.120
            ExPASy - ENZYME nomenclature database: 2.1.1.120
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.120
///
ENTRY       EC 2.1.1.121
NAME        6-O-Methylnorlaudanosoline 5'-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + 6-O-Methylnorlaudanosoline =
            S-Adenosyl-L-homocysteine + Nororientaline
SUBSTRATE   S-Adenosyl-L-methionine
            6-O-Methylnorlaudanosoline
PRODUCT     S-Adenosyl-L-homocysteine
            Nororientaline
COMMENT     Nororientaline is a precursor of the alkaloid papaverine.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.121
            ExPASy - ENZYME nomenclature database: 2.1.1.121
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.121
///
ENTRY       EC 2.1.1.122
NAME        (S)-Tetrahydroprotoberberine N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + (S)-7,8,13,14-Tetrahydroprotoberberine =
            S-Adenosyl-L-homocysteine + cis-N-Methyl-(S)-7,8,13,14-
            $tetrahydroprotoberberine
SUBSTRATE   S-Adenosyl-L-methionine
            (S)-7,8,13,14-Tetrahydroprotoberberine
PRODUCT     S-Adenosyl-L-homocysteine
            cis-N-Methyl-(S)-7,8,13,14-tetrahydroprotoberberine
COMMENT     Involved in the biosynthesis of Isoquinoline alkaloids in plants.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.122
            ExPASy - ENZYME nomenclature database: 2.1.1.122
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.122
///
ENTRY       EC 2.1.1.123
NAME        [Cytochrome c] Methionine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + [Cytochrome c] L-methionine =
            S-Adenosyl-L-homocysteine + [Cytochrome c] S-methyl-L-methionine
SUBSTRATE   S-Adenosyl-L-methionine
            [Cytochrome c] L-methionine
PRODUCT     S-Adenosyl-L-homocysteine
            [Cytochrome c] S-methyl-L-methionine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.123
            ExPASy - ENZYME nomenclature database: 2.1.1.123
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.123
///
ENTRY       EC 2.1.1.124
NAME        [Cytochrome c] Methionine S-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + [Cytochrome c] L-methionine =
            S-Adenosyl-L-homocysteine + [Cytochrome c] S-methyl-L-methionine
SUBSTRATE   S-Adenosyl-L-methionine
            [Cytochrome c] L-methionine
PRODUCT     S-Adenosyl-L-homocysteine
            [Cytochrome c] S-methyl-L-methionine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.124
            ExPASy - ENZYME nomenclature database: 2.1.1.124
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.124
///
ENTRY       EC 2.1.1.125
NAME        Histone-Arginine N-methyltransferase
            Histone protein methylase
            Protein-Arginine N-methyltransferase
            Protein methylase I
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + Histone L-arginine =
            S-Adenosyl-L-homocysteine + Histone N-methyl-L-arginine
SUBSTRATE   S-Adenosyl-L-methionine
            Histone L-arginine
PRODUCT     S-Adenosyl-L-homocysteine
            Histone N-methyl-L-arginine
COMMENT     Forms the N(G)-Monomethyl- and the N(G),N'(G)-Dimethyl-, but not
            the N(G),N'(G)-Dimethyl-arginine derivatives.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.125
            ExPASy - ENZYME nomenclature database: 2.1.1.125
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.125
///
ENTRY       EC 2.1.1.126
NAME        [Myeline basic protein]-Arginine N-methyltransferase
            Myeline basic protein methylase
            Protein-Arginine N-methyltransferase
            Protein methylase I
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + [Myeline basic protein] L-arginine =
            S-Adenosyl-L-homocysteine +
            [Myeline basic protein] N-methyl-L-arginine
SUBSTRATE   S-Adenosyl-L-methionine
            [Myeline basic protein] L-arginine
PRODUCT     S-Adenosyl-L-homocysteine
            [Myeline basic protein] N-methyl-L-arginine
COMMENT     Forms the N(G)-Monomethyl-, N(G),N'(G)-Dimethyl- and N(G),N'(G)-
            Dimethyl-arginine derivatives.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.126
            ExPASy - ENZYME nomenclature database: 2.1.1.126
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.126
///
ENTRY       EC 2.1.1.127
NAME        [Ribulose-bisphosphate-carboxylase]-lysine N-methyltransferase
            Rubisco methyltransferase
            Ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine +
            [Ribulose-1,5-bisphosphate-carboxylase]-lysine =
            S-Adenosyl-L-homocysteine +
            [Ribulose-1,5-bisphosphate-carboxylase]-N6-methyl-L-lysine
SUBSTRATE   S-Adenosyl-L-methionine
            [Ribulose-1,5-bisphosphate-carboxylase]-lysine
PRODUCT     S-Adenosyl-L-homocysteine
            [Ribulose-1,5-bisphosphate-carboxylase]-N6-methyl-L-lysine
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.127
            ExPASy - ENZYME nomenclature database: 2.1.1.127
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.127
///
ENTRY       EC 2.1.1.128
NAME        (R,S)-Norcoclaurine 6-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + (R,S)-Norcoclaurine =
            S-Adenosyl-L-homocysteine + (R,S)-Coclaurine;
            S-Adenosyl-L-methionine + (R,S)-Norlaudanosoline =
            S-Adenosyl-L-homocysteine + 6-O-Methylnorlaudanosoline
SUBSTRATE   S-Adenosyl-L-methionine
            (R,S)-Norcoclaurine
            (R,S)-Norlaudanosoline
PRODUCT     S-Adenosyl-L-homocysteine
            (R,S)-Coclaurine
            6-O-Methylnorlaudanosoline
COMMENT     Norcoclaurine is 6,7-dihydroxy-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-
            tetrahydroisoquinoline.
            The enzyme will also catalyse the 6-O-methylation of (R,S)-
            norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this
            alkaloid has not been found to occur in plants.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.128
            ExPASy - ENZYME nomenclature database: 2.1.1.128
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.128
///
ENTRY       EC 2.1.1.129
NAME        myo-Inositol 4-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + myo-Inositol =
            S-Adenosyl-L-homocysteine + 4-O-Methyl-myo-inositol
SUBSTRATE   S-Adenosyl-L-methionine
            myo-Inositol
PRODUCT     S-Adenosyl-L-homocysteine
            4-O-Methyl-myo-inositol
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.129
            ExPASy - ENZYME nomenclature database: 2.1.1.129
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.129
///
ENTRY       EC 2.1.1.130
NAME        Precorrin-2 C20-methyltransferase
            S-Adenosyl-l-methionine--precorrin-2 methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + Precorrin 2 = S-Adenosyl-L-homocysteine +
            Precorrin 3A
SUBSTRATE   S-Adenosyl-L-methionine
            Precorrin 2
PRODUCT     S-Adenosyl-L-homocysteine
            Precorrin 3A
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       PAE: PA2904(cobI)
            MLO: mlr1380
            SME: SMc03191(cobI)
            CAC: CAC1379(cobI/cbiL)
            MTU: Rv2066(cobI)
            SYN: slr1879(cbiL)
            MJA: MJ0771
            MTH: MTH1348
            AFU: AF0727(cbiL)
            HAL: VNG1551G(cbiL)
            TAC: Ta0658
            TVO: TVG0971375
            SSO: SSO2301(cbiL)
MOTIF       PS: PS00839  [LIVM]-[GS]-[STAL]-G-P-G-x(3)-[LIVMFY]-[LIVM]-T-[LIVM]-
                         [KRHQG]-[AG]
            PS: PS00840  V-x(2)-[LI]-x(2)-G-D-x(3)-[FYW]-[GS]-x(8)-[LIVF]-
                         x(5,6)-[LIVMFYWPAC]-x-[LIVMY]-x-P-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.130
            ExPASy - ENZYME nomenclature database: 2.1.1.130
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.130
///
ENTRY       EC 2.1.1.131
NAME        Precorrin-3B C17-methyltransferase
            Precorrin-3 methyltransferase
            Precorrin-3 methylase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + Precorrin 3B =
            S-Adenosyl-L-homocysteine + Precorrin 4
SUBSTRATE   S-Adenosyl-L-methionine
            Precorrin 3B
PRODUCT     S-Adenosyl-L-homocysteine
            Precorrin 4
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       PAE: PA2903(cobJ)
            MLO: mlr1381
            SME: SMc03190(cobJ)
            CAC: CAC1382(cbiH/cobJ)
            MTU: Rv2066(cobI)
            SYN: slr0969(cbiH)
            MJA: MJ0813
            MTH: MTH1403
            AFU: AF0724(cbiH)
            HAL: VNG1555G(cobH) VNG1557G(cbiH)
            TAC: Ta0655
            TVO: TVG0973788
            SSO: SSO2306(cbiH)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.131
            ExPASy - ENZYME nomenclature database: 2.1.1.131
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.131
///
ENTRY       EC 2.1.1.132
NAME        Precorrin-6Y C5,15-methyltransferase (decarboxylating)
            Precorrin-6 methyltransferase
            Precorrin-6Y methylase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    2 S-Adenosyl-L-methionine + Precorrin 6Y =
            2 S-Adenosyl-L-homocysteine + Precorrin 8X + CO2
SUBSTRATE   S-Adenosyl-L-methionine
            Precorrin 6Y
PRODUCT     S-Adenosyl-L-homocysteine
            Precorrin 8X
            CO2
COMMENT     The enzyme from Pseudomonas denitrificans has S-adenosyl-L-
            methionine-dependent methyltransferase and decarboxylase
            activities.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       SME: SMc03188(cobL)
            MJA: MJ1522(cbiE)
            MTH: MTH1514
            AFU: AF0722(cbiE)
            HAL: VNG1568G(cbiJ)
            TAC: Ta0660
            TVO: TVG0968891
            SSO: SSO2296(cbiE)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.132
            ExPASy - ENZYME nomenclature database: 2.1.1.132
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.132
///
ENTRY       EC 2.1.1.133
NAME        Precorrin-4 C11-methyltransferase
            Precorrin-3 methylase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + Precorrin 4 = S-Adenosyl-L-homocysteine +
            Precorrin 5
SUBSTRATE   S-Adenosyl-L-methionine
            Precorrin 4
PRODUCT     S-Adenosyl-L-homocysteine
            Precorrin 5
COMMENT     Catalyses the methylation of C-11 in precorrin-4 to form
            precorrin-5.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       PAE: PA2948(cobM)
            MLO: mlr1385
            SME: SMc03187(cobM)
            CAC: CAC1380(cbiF/cobM)
            MTU: Rv2071c(cobM)
            MTC: MT2131
            SYN: slr0239(cbiF)
            MJA: MJ1578(cbiF)
            MTH: MTH602
            AFU: AF0726(cbiF)
            HAL: VNG1553G(cbiF)
            TAC: Ta0659
            TVO: TVG0970612 TVG0971163
            SSO: SSO2299(cbiF)
MOTIF       PS: PS00839  [LIVM]-[GS]-[STAL]-G-P-G-x(3)-[LIVMFY]-[LIVM]-T-[LIVM]-
                         [KRHQG]-[AG]
            PS: PS00840  V-x(2)-[LI]-x(2)-G-D-x(3)-[FYW]-[GS]-x(8)-[LIVF]-
                         x(5,6)-[LIVMFYWPAC]-x-[LIVMY]-x-P-G
STRUCTURES  PDB: 1CBF  2CBF  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.133
            ExPASy - ENZYME nomenclature database: 2.1.1.133
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.133
            SCOP (Structural Classification of Proteins): 2.1.1.133
///
ENTRY       EC 2.1.1.134
NAME        myo-Inositol 6-O-methyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    S-Adenosyl-L-methionine + myo-Inositol =
            S-Adenosyl-L-homocysteine + 1D-6-O-Methyl-myo-inositol
SUBSTRATE   S-Adenosyl-L-methionine
            myo-Inositol
PRODUCT     S-Adenosyl-L-homocysteine
            1D-6-O-Methyl-myo-inositol
INHIBITOR   Mn(II)
            Zn(II)
            Cu(II)
COMMENT     The enzyme from Vigna umbellata is highly specific for
            S-adenosyl-L-methionine.
            Also methylates 1L-1,2,4/3,5-cyclohexanepentol, 2,4,6/3,5-penta-
            hydroxycylohexanone, D,L-2,3,4,6/5-pentacyclohexanone and 2,2'-
            anhydro-2-C-hydroxymethyl-myo-inositol at lower rates than that of
            myo-inositol.
            Showed no activity on other naturally occurring isomeric inositols
            and inositol O-methyl-ethers.
            Strongly inhibited by Mn(II), Zn(II), Cu(II) and sulfhydryl group
            inhibitors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.134
            ExPASy - ENZYME nomenclature database: 2.1.1.134
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.134
///
ENTRY       EC 2.1.1.135
NAME        [Methionine synthase]-cobalamin methyltransferase (cob(II)alamin
            $reducing)
            Methionine synthase cob(II)alamin reductase (methylating)
            Methionine synthase reductase
CLASS       Transferases
            Transferring one-carbon groups
            Methyltransferases
REACTION    [Methionine synthase]-cob(II)alamin + NADPH +
            S-Adenosylmethionine = [Methionine synthase]-methylcob(I)alamin +
            S-Adenosylhomocysteine + NADP+
SUBSTRATE   [Methionine synthase]-cob(II)alamin
            NADPH
            S-Adenosylmethionine
PRODUCT     [Methionine synthase]-methylcob(I)alamin
            S-Adenosylhomocysteine
            NADP+
COFACTOR    Flavoprotein
COMMENT     Electrons are probably transferred from NADPH to FAD to FMN.
GENES       HSA: 4552(MTRR)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.1.135
            ExPASy - ENZYME nomenclature database: 2.1.1.135
            WIT (What Is There) Metabolic Reconstruction: 2.1.1.135
///
ENTRY       EC 2.1.2.1
NAME        Glycine hydroxymethyltransferase
            Serine aldolase
            Threonine aldolase
            Serine hydroxymethylase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
REACTION    5,10-Methylenetetrahydrofolate + Glycine + H2O = Tetrahydrofolate
            + L-Serine
SUBSTRATE   5,10-Methylenetetrahydrofolate
            Acetaldehyde
            4-Trimethylammoniobutanal
            Glycine
            H2O
PRODUCT     Tetrahydrofolate
            L-Serine
            L-Threonine
            3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses the reaction of
            glycine with acetaldehyde to form L-threonine, and with
            4-trimethylammoniobutanal to form 3-hydroxy-N6,N6,N6-trimethyl-
            L-lysine.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00310  Lysine degradation
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00680  Methane metabolism
GENES       ECO: b2551(glyA)
            ECE: Z3827(glyA)
            ECS: ECs3417
            YPE: YPO2907(glyA)
            HIN: HI0889(glyA)
            PMU: PM0225(glyA)
            XFA: XF0946
            VCH: VC0941 VCA0278
            PAE: PA2444(glyA2) PA4602(glyA3) PA5415(glyA1)
            BUC: BU289(glyA)
            NME: NMB1055
            NMA: NMA1254(glyA)
            HPY: HP0183(glyA)
            HPJ: jhp0171
            CJE: Cj0402(glyA)
            RPR: RP743(glyA)
            RCO: RC1146(glyA)
            MLO: mlr6114 mlr8400
            SME: SMa2135(glyA2) SMc01770(glyA1)
            CCR: CC1357
            BSU: BG10944(glyA)
            BHA: BH3765(glyA)
            SAU: SA1915(glyA)
            SAV: SAV2100(glyA)
            LLA: L0082(glyA)
            SPY: SPy1145(glyA)
            SPN: SP1024
            SPR: spr0928(glyA)
            CAC: CAC2264(glyA)
            MGE: MG394(glyA)
            MPN: D02_orf406(glyA)
            MPU: MYPU_3390(glyA)
            MTU: Rv0070c(glyA2) Rv1093(glyA)
            MTC: MT0076 MT1125
            MLE: ML1953(glyA)
            CTR: CT432
            CMU: TC0716
            CPN: CPn0521
            CPA: CP0232
            CPJ: glyA
            BBU: BB0601(glyA)
            TPA: TP0329
            SYN: sll1931(glyA)
            DRA: DR0038
            AAE: aq_479(glyA)
            TMA: TM0720
            MJA: MJ1597(glyA)
            MTH: MTH1380(glyA)
            AFU: AF0852(glyA)
            HAL: VNG1414G(glyA)
            TAC: Ta0811 Ta1509
            TVO: TVG0048225 TVG0811706
            PHO: PH1654
            PAB: PAB2018(glyA)
            APE: APE1962
            SSO: SSO0530(glyA)
            STO: ST1354
            SCE: YBR263W(SHM1) YLR058C(SHM2)
            SPO: SHM2(shm2) SPAC24C9.12C(spac24c9.12c)
            CEL: mel-32
            DME: CG3011
            HSA: 6470(SHMT1) 6472(SHMT2)
DISEASE     MIM: 138450  Serine hydroxymethyltransferase
            MIM: 182144  Serine hydroxymethyltransferase (soluble)
MOTIF       PS: PS00096  [DEQH]-[LIVMFYA]-x-[GSTMV]-[GSTA]-[ST](2)-H-K-[ST]-
                         [LF]-x-G-[PGAC]-[RQ]-[GSA]-[GA]
STRUCTURES  PDB: 1BJ4  1DFO  1EJI  1EQB  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.1
            ExPASy - ENZYME nomenclature database: 2.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.1
            BRENDA, the Enzyme Database: 2.1.2.1
            SCOP (Structural Classification of Proteins): 2.1.2.1
///
ENTRY       EC 2.1.2.2
NAME        Phosphoribosylglycinamide formyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     10-Formyltetrahydrofolate:5'-phosphoribosylglycinamide formyl-
            transferase
REACTION    10-Formyltetrahydrofolate +
            5'-Phosphoribosylglycinamide = Tetrahydrofolate +
            5'-Phosphoribosyl-N-formylglycinamide
SUBSTRATE   10-Formyltetrahydrofolate
            5'-Phosphoribosylglycinamide
PRODUCT     Tetrahydrofolate
            5'-Phosphoribosyl-N-formylglycinamide
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b2500(purN)
            ECE: Z3763(purN)
            ECS: ECs3362
            YPE: YPO2829(purN)
            HIN: HI1428(purN)
            PMU: PM0020(purN)
            XFA: XF0585
            VCH: VC2227
            PAE: PA0944(purN)
            NME: NMB1566
            NMA: NMA1755(purN)
            CJE: Cj0187c(purN)
            MLO: mll7961
            SME: SMc00614(purN)
            CCR: CC1702
            BSU: BG10709(purN)
            BHA: BH0632(purN)
            SAU: SA0924(purN)
            SAV: SAV1058(purN)
            LLA: L164626(purN)
            SPY: SPy0028(purN)
            SPN: SP0048
            SPR: spr0049(purN)
            CAC: CAC1394(PurN)
            MTU: Rv0956(purN)
            MTC: MT0983
            MLE: ML0160(purN)
            SYN: slr0477(purN)
            DRA: DR2026
            AAE: aq_857(purN)
            TMA: TM1248
            TAC: Ta0082
            TVO: TVG0180390
            SCE: YDR408C(ADE8)
            SPO: SPCC569.08C
            DME: CG8761(ade3)
            HSA: 2618(GART)
MOTIF       PS: PS00184  R-[LF]-G-D-P-E-x-[EQIM]
            PS: PS00373  G-x-[STM]-[IVT]-x-[FYWVQ]-[VMAT]-x-[DEVM]-x-[LIVMY]-D-
                         x-G-x(2)-[LIVT]-x(6)-[LIVM]
STRUCTURES  PDB: 1C2T  1C3E  1CDD  1CDE  1GAR  1GRC  2GAR  3GAR  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.2
            ExPASy - ENZYME nomenclature database: 2.1.2.2
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.2
            BRENDA, the Enzyme Database: 2.1.2.2
            SCOP (Structural Classification of Proteins): 2.1.2.2
///
ENTRY       EC 2.1.2.3
NAME        Phosphoribosylaminoimidazolecarboxamide formyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     10-Formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-
            carboxamide formyltransferase
REACTION    10-Formyltetrahydrofolate +
            1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide =
            Tetrahydrofolate +
            1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
SUBSTRATE   10-Formyltetrahydrofolate
            1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
PRODUCT     Tetrahydrofolate
            1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b4006(purH)
            ECE: Z5583(purH)
            ECS: ECs4929
            YPE: YPO3728(purH)
            HIN: HI0887(purH)
            PMU: PM0222(purH)
            XFA: XF1975
            VCH: VC0276
            PAE: PA4854(purH)
            BUC: BU031(purH)
            NME: NMB0983
            NMA: NMA1182(purH)
            CJE: Cj0953c(purH)
            MLO: mlr4101
            SME: SMc04088(purH)
            CCR: CC0086
            BSU: BG10710(purH)
            BHA: BH0633(purH)
            SAU: SA0925(purH)
            SAV: SAV1059(purH)
            LLA: L158710(purH)
            SPN: SP0050
            SPR: spr0051(purH)
            CAC: CAC1395(purH)
            MTU: Rv0957(purH)
            MTC: MT0984
            MLE: ML0161(purH)
            SYN: slr0597(purH)
            DRA: DR0868
            AAE: aq_1963(purH)
            TMA: TM1249
            HAL: VNG0414G(purH)
            TAC: Ta0060
            TVO: TVG0015470
            SCE: YLR028C(ADE16) YMR120C(ADE17)
            SPO: ADE10(ade10)
            DME: CG11089
            HSA: 471(ATIC)
STRUCTURES  PDB: 1G8M  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.3
            ExPASy - ENZYME nomenclature database: 2.1.2.3
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.3
            BRENDA, the Enzyme Database: 2.1.2.3
///
ENTRY       EC 2.1.2.4
NAME        Glycine formiminotransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5-Formiminotetrahydrofolate:glycine N-formiminotransferase
REACTION    5-Formiminotetrahydrofolate + Glycine = Tetrahydrofolate +
            N-Formiminoglycine
SUBSTRATE   5-Formiminotetrahydrofolate
            Glycine
PRODUCT     Tetrahydrofolate
            N-Formiminoglycine
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00670  One carbon pool by folate
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.4
            ExPASy - ENZYME nomenclature database: 2.1.2.4
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.4
            BRENDA, the Enzyme Database: 2.1.2.4
///
ENTRY       EC 2.1.2.5
NAME        Glutamate formiminotransferase
            Glutamate formyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5-Formiminotetrahydrofolate:L-glutamate N-formiminotransferase
REACTION    5-Formiminotetrahydrofolate + L-Glutamate = Tetrahydrofolate +
            N-Formimino-L-glutamate
SUBSTRATE   5-Formiminotetrahydrofolate
            L-Glutamate
            5-Formyltetrahydrofolate
PRODUCT     Tetrahydrofolate
            N-Formimino-L-glutamate
            N-Formyl-L-glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses formyl transfer
            from 5-formyltetrahydrofolate to L-glutamate (a reaction formerly
            listed as EC 2.1.2.6). In eukaryotes occurs as a bifunctional
            enzyme also having formiminotetrahydrofolate cyclodeaminase
            activity (EC 4.3.1.4).
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       HSA: 10841(FTCD)
STRUCTURES  PDB: 1QD1  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.5
            ExPASy - ENZYME nomenclature database: 2.1.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.5
            BRENDA, the Enzyme Database: 2.1.2.5
            SCOP (Structural Classification of Proteins): 2.1.2.5
///
ENTRY       EC 2.1.2.6
NAME        Deleted entry
            Glutamate formyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
COMMENT     Deleted entry. Now included with EC 2.1.2.5.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.6
            ExPASy - ENZYME nomenclature database: 2.1.2.6
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.6
///
ENTRY       EC 2.1.2.7
NAME        D-Alanine 2-hydroxymethyltransferase
            2-Methylserine hydroxymethyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5,10-Methylenetetrahydrofolate:D-alanine
            $ 2-hydroxymethyltransferase
REACTION    5,10-Methylenetetrahydrofolate + D-Alanine + H2O =
            Tetrahydrofolate + 2-Methylserine
SUBSTRATE   5,10-Methylenetetrahydrofolate
            D-Alanine
            H2O
            2-Hydroxymethylserine
PRODUCT     Tetrahydrofolate
            2-Methylserine
COMMENT     Also acts on 2-hydroxymethylserine.
PATHWAY     PATH: MAP00670  One carbon pool by folate
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.7
            ExPASy - ENZYME nomenclature database: 2.1.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.7
            BRENDA, the Enzyme Database: 2.1.2.7
///
ENTRY       EC 2.1.2.8
NAME        Deoxycytidylate 5-hydroxymethyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5,10-Methylenetetrahydrofolate:deoxycytidylate
            5'-hydroxymethyltransferase
REACTION    5,10-Methylenetetrahydrofolate + H2O + Deoxycytidylate =
            Tetrahydrofolate + 5-Hydroxymethyldeoxycytidylate
SUBSTRATE   5,10-Methylenetetrahydrofolate
            H2O
            Deoxycytidylate
PRODUCT     Tetrahydrofolate
            5-Hydroxymethyldeoxycytidylate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00670  One carbon pool by folate
STRUCTURES  PDB: 1B49  1B5D  1B5E  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.8
            ExPASy - ENZYME nomenclature database: 2.1.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.8
            BRENDA, the Enzyme Database: 2.1.2.8
            SCOP (Structural Classification of Proteins): 2.1.2.8
///
ENTRY       EC 2.1.2.9
NAME        Methionyl-tRNA formyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
REACTION    10-Formyltetrahydrofolate + L-Methionyl-tRNA + H2O =
            Tetrahydrofolate + N-Formylmethionyl-tRNA
SUBSTRATE   10-Formyltetrahydrofolate
            L-Methionyl-tRNA
            H2O
PRODUCT     Tetrahydrofolate
            N-Formylmethionyl-tRNA
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b3288(fmt)
            ECE: Z4658(fmt)
            ECS: ECs4153
            YPE: YPO0241(fmt)
            HIN: HI0623(fmt)
            PMU: PM1560(fmt)
            XFA: XF0927
            VCH: VC0045
            PAE: PA0018(fmt)
            BUC: BU497(fmt)
            NME: NMB0111
            NMA: NMA0163(fmt)
            HPY: HP1141(fmt)
            HPJ: jhp1069
            CJE: Cj0098(fmt)
            RPR: RP209(fmt)
            RCO: RC0279(fmt)
            MLO: mll4854
            SME: SMc01100(fmt)
            CCR: CC0279
            BSU: BG11937(fmt)
            BHA: BH2508(fmt)
            SAU: SA1059
            SAV: SAV1203(fmt)
            LLA: L0362(fmt)
            SPY: SPy1628(fmt)
            SPN: SP1735
            SPR: spr1580(fmt)
            CAC: CAC1723(fmt)
            MGE: MG365(fmt)
            MPN: G12_orf311(fmt)
            MPU: MYPU_0450(fmt)
            UUR: UU463(fmt)
            MTU: Rv1406(fmt)
            MTC: MT1450
            MLE: ML0552(fmt)
            CTR: CT530
            CMU: TC0817
            CPN: CPn0649
            CPA: CP0098
            CPJ: fmt
            BBU: BB0064(fmt)
            TPA: TP0756
            SYN: slr0070(fmt)
            DRA: DR2435
            AAE: aq_2131(fmt)
            TMA: TM0528
            SCE: YBL013W(FMT1)
MOTIF       PS: PS00373  G-x-[STM]-[IVT]-x-[FYWVQ]-[VMAT]-x-[DEVM]-x-[LIVMY]-D-
                         x-G-x(2)-[LIVT]-x(6)-[LIVM]
STRUCTURES  PDB: 1FMT  2FMT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.9
            ExPASy - ENZYME nomenclature database: 2.1.2.9
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.9
            BRENDA, the Enzyme Database: 2.1.2.9
            SCOP (Structural Classification of Proteins): 2.1.2.9
///
ENTRY       EC 2.1.2.10
NAME        Aminomethyltransferase
            T-Protein
            Tetrahydrofolate aminomethyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate
            aminomethyltransferase (ammonia-forming)
REACTION    (6S)-Tetrahydrofolate + S-Aminomethyldihydrolipoylprotein =
            (6R)-5,10-Methylenetetrahydrofolate + NH3 +
            Dihydrolipoylprotein
SUBSTRATE   (6S)-Tetrahydrofolate
            S-Aminomethyldihydrolipoylprotein
PRODUCT     (6R)-5,10-Methylenetetrahydrofolate
            NH3
            Dihydrolipoylprotein
COMMENT     A component, with EC 1.4.4.2 of the glycine cleavage system,
            formerly known as glycine synthase.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b2905(gcvT)
            ECE: Z4242(gcvT)
            ECS: ECs3776
            YPE: YPO0907(gcvT)
            XFA: XF0183
            PAE: PA2442(gcvT2) PA5215(gcvT1)
            NME: NMB0574
            NMA: NMA0758(gcvT)
            MLO: mll7302 mlr0883 mlr3677 mlr4790 mlr7320
            SME: SMc02047(gcvT)
            CCR: CC3355
            BSU: BG11509(gcvT)
            BHA: BH2816
            SAU: SA1367
            SAV: SAV1526
            MTU: Rv2211c(gcvT)
            MTC: MT2267
            MLE: ML0865(gcvT)
            SYN: sll0171(gcvT)
            AAE: aq_1458(gcvT)
            TMA: TM0211
            HAL: VNG1606G(gcvT1) VNG2640G(gcvT2)
            TAC: Ta0010
            TVO: TVG0060439
            PHO: PH1146
            PAB: PAB1638
            APE: APE1695
            SSO: SSO0919
            STO: ST1206
            SCE: YDR019C(GCV1)
            SPO: N313(n313)
            ATH: At1g11860(F12F1.30)
            CEL: F25B4.1
            DME: CG6415
            HSA: 275(AMT)
DISEASE     MIM: 238310  Aminomethyltransferase (glycine cleavage system
                         protein T)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.10
            ExPASy - ENZYME nomenclature database: 2.1.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.10
            BRENDA, the Enzyme Database: 2.1.2.10
///
ENTRY       EC 2.1.2.11
NAME        3-Methyl-2-oxobutanoate hydroxymethyltransferase
            alpha-Ketoisovalerate hydroxymethyltransferase
            Dehydropantoate hydroxymethyltransferase
            Ketopantoate hydroxymethyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Hydroxymethyl-, formyl- and related transferases
SYSNAME     5,10-Methylenetetrahydrofolate:3-methyl-2-oxobutanoate
            $ hydroxymethyltransferase
REACTION    5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxobutanoate =
            Tetrahydrofolate + 2-Dehydropantoate
SUBSTRATE   5,10-Methylenetetrahydrofolate
            3-Methyl-2-oxobutanoate
PRODUCT     Tetrahydrofolate
            2-Dehydropantoate
PATHWAY     PATH: MAP00670  One carbon pool by folate
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b0134(panB)
            ECE: Z0145(panB)
            ECS: ECs0138
            YPE: YPO3401(panB)
            XFA: XF0229
            VCH: VC0592
            PAE: PA1598 PA4729
            BUC: BU197(panB)
            NME: NMB0870
            NMA: NMA1088(panB)
            HPY: HP1058(panB)
            HPJ: jhp0367
            CJE: Cj0298c(panB)
            MLO: mll0197 mll1731 mlr7631
            SME: SMc01881(panB)
            CCR: CC1651
            BSU: BG11519(panB)
            BHA: BH1687(panB)
            SAU: SA2392(panB)
            SAV: SAV2583(panB)
            CAC: CAC2914(panB)
            MTU: Rv2225(panB)
            MTC: MT2284
            MLE: ML1635(panB)
            SYN: slr0526(panB)
            DRA: DR2615
            AAE: aq_1973(panB)
            TMA: TM1728
            HAL: VNG1478G(panB)
            PHO: PH0951
            PAB: PAB0570
            APE: APE0676
            SSO: SSO2400(panB)
            STO: ST0533
            SCE: YBR176W(ECM31)
            SPO: SPAC5H10.09C(spac5h10.09c)
            ATH: At2g46110(T3F17.18) At3g61530(F2A19.130)
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.2.11
            ExPASy - ENZYME nomenclature database: 2.1.2.11
            WIT (What Is There) Metabolic Reconstruction: 2.1.2.11
            BRENDA, the Enzyme Database: 2.1.2.11
///
ENTRY       EC 2.1.3.1
NAME        Methylmalonyl-CoA carboxyltransferase
            Transcarboxylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     (S)-2-Methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase
REACTION    (S)-2-Methyl-3-oxopropanoyl-CoA + Pyruvate = Propanoyl-CoA +
            Oxaloacetate
SUBSTRATE   (S)-2-Methyl-3-oxopropanoyl-CoA
            Pyruvate
PRODUCT     Propanoyl-CoA
            Oxaloacetate
COFACTOR    Biotin
            Cobalt
            Zinc
COMMENT     A biotinyl-protein, containing cobalt and zinc.
PATHWAY     PATH: MAP00640  Propanoate metabolism
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
STRUCTURES  PDB: 1DCZ  1DD2  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.1
            ExPASy - ENZYME nomenclature database: 2.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.1
            BRENDA, the Enzyme Database: 2.1.3.1
            SCOP (Structural Classification of Proteins): 2.1.3.1
///
ENTRY       EC 2.1.3.2
NAME        Aspartate carbamoyltransferase
            Carbamylaspartotranskinase
            Aspartate transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:L-aspartate carbamoyltransferase
REACTION    Carbamoyl phosphate + L-Aspartate = Orthophosphate +
            N-Carbamoyl-L-aspartate
SUBSTRATE   Carbamoyl phosphate
            L-Aspartate
PRODUCT     Orthophosphate
            N-Carbamoyl-L-aspartate
INHIBITOR   CTP
            UTP
EFFECTOR    ATP
COMMENT     The formation of cytidine triphosphate in E. coli is controlled by
            feedback (end-product) inhibiton.  As a critical concentration of
            CTP is build up, CTP slows down its own formation by inhibiting
            this enzyme.  This enzyme is composed of two large subunits, one
            of which carries the catalytic site and the other the regulatory
            site.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
GENES       ECO: b4244(pyrI) b4245(pyrB)
            ECE: Z5855(pyrI) Z5856(pyrB)
            ECS: ECs5221 ECs5222
            YPE: YPO3588(pyrB)
            XFA: XF2226
            VCH: VC2510 VC2511
            PAE: PA0402(pyrB)
            BUC: BU369(pyrB) BU370(pyrI)
            NME: NMB0106 NMB0107
            NMA: NMA0167(pyrI) NMA0168(pyrB)
            HPY: HP1084(pyrB)
            HPJ: jhp0341
            CJE: Cj1098(pyrB)
            MLO: mlr0686
            SME: SMc01360(pyrB)
            CCR: CC2443
            BSU: BG10713(pyrB)
            BHA: BH2539(pyrB)
            SAU: SA1043(pyrB)
            SAV: SAV1187(pyrB)
            LLA: L45002(pyrB)
            SPY: SPy0832(pyrB)
            SPN: SP1277
            SPR: spr1155(pyrB)
            CAC: CAC2653(pyrI) CAC2654
            MTU: Rv1380(pyrB)
            MTC: MT1424
            MLE: ML0532(pyrB)
            SYN: slr1476(pyrB)
            DRA: DR1109
            AAE: aq_409(pyrB)
            TMA: TM1642
            MJA: MJ1406(pyrI) MJ1581(pyrB)
            MTH: MTH1413 MTH850
            AFU: AF0106(pyrB) AF0107(pyrI)
            HAL: VNG6309G(pyrB) VNG6311G(pyrI)
            TAC: Ta0574 Ta0575
            TVO: TVG0624440 TVG0624900
            PHO: PH0720 PH0721
            PAB: PAB1498(pyrB) PAB1499(pyrI)
            APE: APE1662 APE1663
            SSO: SSO0613(pyrI) SSO0614(pyrB)
            SCE: YJL130C(URA2)
            SPO: URA1(ura1)
            CEL: D2085.1
            HSA: 790(CAD)
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
            PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00482  D-[LIVMFYWSAP]-H-[LIVA]-H-[LIVF]-[RN]-x-[PGANF]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
STRUCTURES  PDB: 1ACM  1AT1  1D09  1EKX  1EZZ  1F1B  1I5O  1NBE  1RAA  1RAB  
                 1RAC  1RAD  1RAE  1RAF  1RAG  1RAH  1RAI  2AT1  2AT2  2ATC  
                 3AT1  3CSU  4AT1  5AT1  6AT1  7AT1  8AT1  8ATC  9ATC  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.2
            ExPASy - ENZYME nomenclature database: 2.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.2
            BRENDA, the Enzyme Database: 2.1.3.2
            SCOP (Structural Classification of Proteins): 2.1.3.2
///
ENTRY       EC 2.1.3.3
NAME        Ornithine carbamoyltransferase
            Citrulline phospharylase
            Ornithine transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:L-ornithine carbamoyltransferase
REACTION    Carbamoyl phosphate + L-Ornithine = Orthophosphate + L-Citrulline
SUBSTRATE   Carbamoyl phosphate
            L-Ornithine
            Putrescine
            ATP
            NH3
            CO2
            Agmatine
            H2O
PRODUCT     Orthophosphate
            L-Citrulline
            Putrescine
            ADP
            Carbamoyl phosphate
            N-Carbamoylputrescine
            NH3
COMMENT     The plant enzyme also catalyses the reactions of EC 2.1.3.6,
            2.7.2.2 and 3.5.3.12, thus acting as putrescine synthase,
            converting agmatine and ornithine into putrescine and citrulline
            respectively.
            (EC 2.1.3.6 Putrescine carbamoyltransferase)
            (EC 2.7.2.2 Carbamate kinase)
            (EC 3.5.3.12 Agmatine deaminas)
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b0273(argF) b4254(argI)
            ECE: Z5866(argI)
            ECS: ECs5231
            YPE: YPO3446(argI)
            HIN: HI0596(arcB)
            PMU: PM0808(arg)
            XFA: XF0998
            VCH: VC2508
            PAE: PA3537(argF) PA5172(arcB)
            BUC: BU368(argF)
            NME: NMB1573
            NMA: NMA1762(argF)
            CJE: Cj0994c(argF)
            MLO: mlr5647
            SME: SMc02137(argF1)
            CCR: CC2242
            BSU: BG10197(argF)
            BHA: BH2894(argf)
            SAU: SA1012(argF) SA2427(arcB)
            SAV: SAV1153(argF) SAV2618(arcB)
            LLA: L0108(argF) L0109(arcB) L0113(otcA)
            SPY: SPy1544(arcB)
            SPN: SP2150
            SPR: spr1957(arcB)
            CAC: CAC0316(argF/I)
            MPN: H10_orf273o(argI)
            MTU: Rv1656(argF)
            MTC: MT1694
            MLE: ML1410(argF)
            BBU: BB0842(arcB)
            SYN: sll0902(argF)
            DRA: DR0080
            AAE: aq_1711(argF)
            TMA: TM1097
            MJA: MJ0881(argF)
            MTH: MTH1446
            AFU: AF1255(argF)
            HAL: VNG6315G(arcB)
            TAC: Ta1330
            TVO: TVG0283269
            PHO: PH0726
            PAB: PAB1502(argF)
            APE: APE1992
            SSO: SSO0871(argF)
            STO: ST1245
            SCE: YJL088W(ARG3)
            SPO: ARG3(arg3)
            MMU: 97448(Otc)
            HSA: 5009(OTC)
DISEASE     MIM: 311250  Ornithine transcarbamylase
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
STRUCTURES  PDB: 1A1S  1AKM  1C9Y  1DUV  1DXH  1EP9  1FVO  1ORT  2OTC  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.3
            ExPASy - ENZYME nomenclature database: 2.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.3
            BRENDA, the Enzyme Database: 2.1.3.3
            SCOP (Structural Classification of Proteins): 2.1.3.3
///
ENTRY       EC 2.1.3.4
NAME        Deleted entry
            Malonyl-CoA carboxyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.4
            ExPASy - ENZYME nomenclature database: 2.1.3.4
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.4
///
ENTRY       EC 2.1.3.5
NAME        Oxamate carbamoyltransferase
            Oxamic transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:oxamate carbamoyltransferase
REACTION    Carbamoyl phosphate + Oxamate = Orthophosphate + Oxalureate
SUBSTRATE   Carbamoyl phosphate
            Oxamate
PRODUCT     Orthophosphate
            Oxalureate
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.5
            ExPASy - ENZYME nomenclature database: 2.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.5
            BRENDA, the Enzyme Database: 2.1.3.5
///
ENTRY       EC 2.1.3.6
NAME        Putrescine carbamoyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:putrescine carbamoyltransferase
REACTION    Carbamoyl phosphate + Putrescine = Orthophosphate +
            N-Carbamoylputrescine
SUBSTRATE   Carbamoyl phosphate
            Putrescine
            Agmatine
            Ornithine
PRODUCT     Orthophosphate
            N-Carbamoylputrescine
            Putrescine
            Citrulline
COMMENT     The plant enzyme also catalyses the reactions of EC 2.1.3.3,
            converting agmatine and ornithine into putrescine and citrulline
            respectively.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.6
            ExPASy - ENZYME nomenclature database: 2.1.3.6
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.6
            BRENDA, the Enzyme Database: 2.1.3.6
///
ENTRY       EC 2.1.3.7
NAME        3-Hydroxymethylcephem carbamoyltransferase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate
            $ carbamoyltransferase
REACTION    Carbamoyl phosphate + a 3-Hydroxymethyl ceph-3-em-4-carboxylate =
            Orthophosphate + a 3-Carbamoyloxymethylcephem
SUBSTRATE   Carbamoyl phosphate
            3-Hydroxymethyl ceph-3-em-4-carboxylate
PRODUCT     Orthophosphate
            3-Carbamoyloxymethylcephem
EFFECTOR    ATP
COMMENT     Acts on a wide range of 3-hydroxymethylcephems (a subclass of the
            cephalosporin antibiotics). Activated by ATP.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.7
            ExPASy - ENZYME nomenclature database: 2.1.3.7
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.7
            BRENDA, the Enzyme Database: 2.1.3.7
///
ENTRY       EC 2.1.3.8
NAME        Lysine carbamoyltransferase
            Lysine transcarbamylase
CLASS       Transferases
            Transferring one-carbon groups
            Carboxyl- and carbamoyltransferases
SYSNAME     Carbamoyl-phosphate:L-lysine carbamoyltransferase
REACTION    Carbamoyl phosphate + L-Lysine = Orthophosphate + L-Homocitrulline
SUBSTRATE   Carbamoyl phosphate
            L-Lysine
PRODUCT     Orthophosphate
            L-Homocitrulline
COMMENT     Not identical with EC 2.1.3.3.
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.3.8
            ExPASy - ENZYME nomenclature database: 2.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 2.1.3.8
            BRENDA, the Enzyme Database: 2.1.3.8
///
ENTRY       EC 2.1.4.1
NAME        Glycine amidinotransferase
CLASS       Transferases
            Transferring one-carbon groups
            Amidinotransferases
SYSNAME     L-Arginine:glycine amidinotransferase
REACTION    L-Arginine + Glycine = L-Ornithine + Guanidinoacetate
SUBSTRATE   L-Arginine
            Glycine
            Canavanine
PRODUCT     L-Ornithine
            Guanidinoacetate
COMMENT     Canavanine can act instead of arginine. Formerly EC 2.6.2.1.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       HSA: 2628(GATM)
STRUCTURES  PDB: 1JDW  1JDX  2JDW  2JDX  3JDW  4JDW  5JDW  6JDW  7JDW  8JDW  
                 9JDW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.4.1
            ExPASy - ENZYME nomenclature database: 2.1.4.1
            WIT (What Is There) Metabolic Reconstruction: 2.1.4.1
            BRENDA, the Enzyme Database: 2.1.4.1
            SCOP (Structural Classification of Proteins): 2.1.4.1
///
ENTRY       EC 2.1.4.2
NAME        Inosamine-phosphate amidinotransferase
CLASS       Transferases
            Transferring one-carbon groups
            Amidinotransferases
SYSNAME     L-Arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amindino-
            transferase
REACTION    L-Arginine + 1-Amino-1-deoxy-scyllo-inositol 4-phosphate =
            L-Ornithine + 1-Guanidino-1-deoxy-scyllo-inositol 4-phosphate
SUBSTRATE   L-Arginine
            Canavanine
            1-Amino-1-deoxy-scyllo-inositol 4-phosphate
            1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate
            Streptamine phosphate
            2-Deoxystreptamine phospahte
PRODUCT     L-Ornithine
            1-Guanidino-1-deoxy-scyllo-inositol 4-phosphate
COMMENT     1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate,
            streptamine phosphate and 2-deoxystreptamine phosphate can also
            act as acceptors; canavanine can act as donor.
STRUCTURES  PDB: 1BWD  
DBLINKS     IUBMB Enzyme Nomenclature: 2.1.4.2
            ExPASy - ENZYME nomenclature database: 2.1.4.2
            WIT (What Is There) Metabolic Reconstruction: 2.1.4.2
            BRENDA, the Enzyme Database: 2.1.4.2
            SCOP (Structural Classification of Proteins): 2.1.4.2
///
ENTRY       EC 2.2.1.1
NAME        Transketolase
            Glycolaldehydetransferase
CLASS       Transferases
            Transferring aldehyde or ketone residues
SYSNAME     Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate
            glycolaldehyde transferase
REACTION    Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate =
            D-Ribose 5-phosphate + D-Xylulose 5-phosphate;
            D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate =
            D-Erythrose 4-phosphate + D-Xylulose 5-phosphate
SUBSTRATE   Sedoheptulose 7-phosphate
            D-Glyceraldehyde 3-phosphate
            Hydroxypyruvate
            R-CHO
            D-Erythrose
            D-Fructose 6-phosphate
PRODUCT     D-Ribose 5-phosphate
            D-Xylulose 5-phosphate
            CO2
            R-CHOH-CO-CH2OH
            D-Erythrose 4-phosphate
COFACTOR    Thiamine diphosphate
            Magnesium
COMMENT     A thiamine-diphosphate protein.
            Wide specificity for both reactants, e.g. converts
            hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH.
            Transketolase from Alkaligenes faecalis shows high
            activity with D-erythrose as acceptor
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00710  Carbon fixation
GENES       ECO: b2465(tktB) b2935(tktA)
            ECE: Z3721(tktB) Z4279(tktA)
            ECS: ECs3327 ECs3810
            YPE: YPO0926(tktA) YPO3313 YPO3314
            HIN: HI1023(tktA)
            PMU: PM1242(tkt_1) PM1638(tkt_2)
            XFA: XF1936
            VCH: VC0473 VCA0624
            PAE: PA0548(tktA)
            BUC: BU094(tktB)
            NME: NMB1457
            NMA: NMA1669(tkt)
            HPY: HP1088(tktA)
            HPJ: jhp0337
            CJE: Cj1645(tkt)
            MLO: mll5764 mll5765 mlr3749
            SME: SMb20200(cbbT) SMc02342(tkt1) SMc03978(tkt2)
            CCR: CC3620
            BSU: BG11247(tkt)
            BHA: BH2352(tkt)
            SAU: SA1177(tkt)
            SAV: SAV1327(tkt)
            LLA: L0043(tkt)
            SPY: SPy1676(tkt)
            SPN: SP2030 SP2127 SP2128
            SPR: spr1841(tktA)
            CAC: CAC0944(tkt) CAC1348
            MGE: MG066(tktA)
            MPN: R02_orf648(tklB)
            MPU: MYPU_5110(tkt)
            UUR: UU586(tktA)
            MTU: Rv1449c(tkt)
            MTC: MT1496
            MLE: ML0583(tkt)
            CTR: CT750
            CMU: TC0131
            CPN: CPn0893
            CPA: CP0973
            CPJ: tktB_1
            TPA: TP0560
            SYN: sll1070(tktA)
            DRA: DR2256
            AAE: aq_1765(tktA)
            TMA: TM1762
            MJA: MJ0679 MJ0681
            TAC: Ta0617 Ta0618
            TVO: TVG0661085 TVG0662032
            PAB: PAB0295(tkt1) PAB0296(tkt2)
            APE: APE0583 APE0586
            SSO: SSO0297(tkt-1) SSO0299(tkt-2)
            SCE: YBR117C(TKL2) YPR074C(TKL1)
            SPO: SPBC2G5.05(spbc2g5.05)
            CEL: F01G10.1
            DME: CG5103 CG8036
            MMU: 105992(Tkt)
            HSA: 7086(TKT) 8277(TKTL1)
MOTIF       PS: PS00801  R-x(3)-[LIVMTA]-[DENQSTHKF]-x(5,6)-[GSN]-G-H-[PLIVMF]-
                         [GSTA]-x(2)-[LIMC]-[GS]
            PS: PS00802  G-[DEQGSA]-[DN]-G-[PAEQ]-[ST]-[HQ]-x-[PAGM]-[LIVMYAC]-
                         [DEFYW]-x(2)-[STAP]-x(2)-[RGA]
STRUCTURES  PDB: 1AY0  1NGS  1TKA  1TKB  1TKC  1TRK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.2.1.1
            ExPASy - ENZYME nomenclature database: 2.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.2.1.1
            BRENDA, the Enzyme Database: 2.2.1.1
            SCOP (Structural Classification of Proteins): 2.2.1.1
///
ENTRY       EC 2.2.1.2
NAME        Transaldolase
            Dihydroxyacetonetransferase
CLASS       Transferases
            Transferring aldehyde or ketone residues
SYSNAME     Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycerone-
            transferase
REACTION    Sedoheptulose 7-phosphate + D-Glyceraldehyde 3-phosphate =
            D-Erythrose 4-phosphate + D-Fructose 6-phosphate
SUBSTRATE   Sedoheptulose 7-phosphate
            D-Glyceraldehyde 3-phosphate
PRODUCT     D-Erythrose 4-phosphate
            D-Fructose 6-phosphate
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b0008(talB) b2464(talA)
            ECE: Z0008(talB) Z3720(talA)
            ECS: ECs0008 ECs3326
            YPE: YPO0463(talB)
            HIN: HI1125(talB)
            PMU: PM1602(tal_1) PM1639(tal_2)
            VCH: VCA0623
            PAE: PA2796(tal)
            BUC: BU093(talA)
            NME: NMB0351
            NMA: NMA2136(tal)
            HPY: HP1495(tal)
            HPJ: jhp1388
            CJE: Cj0281c(tal)
            MTU: Rv1448c(tal)
            MTC: MT1495
            MLE: ML0582(tal)
            CTR: CT313
            CMU: TC0587
            CPN: CPn0083
            CPA: CP0692
            CPJ: tal
            SYN: slr1793(talB)
            DRA: DR1337
            SCE: YGR043C(YGR043C) YLR354C(TAL1)
            SPO: TAL1(tal1)
            DME: CG2827
            HSA: 6888(TALDO1)
MOTIF       PS: PS00958  [LIVM]-x-[LIVM]-K-[LIVM]-[PAS]-x-[ST]-x-[DENQPAS]-G-
                         [LIVM]-x-[AGV]-x-[QEKRST]-x-[LIVM]
            PS: PS01054  [DG]-[IVSA]-T-[ST]-N-P-[STA]-[LIVMF](2)
STRUCTURES  PDB: 1F05  1I2N  1I2O  1I2P  1I2Q  1I2R  1ONR  1UCW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.2.1.2
            ExPASy - ENZYME nomenclature database: 2.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.2.1.2
            BRENDA, the Enzyme Database: 2.2.1.2
            SCOP (Structural Classification of Proteins): 2.2.1.2
///
ENTRY       EC 2.2.1.3
NAME        Formaldehyde transketolase
            Dihydroxyacetone synthase
CLASS       Transferases
            Transferring aldehyde or ketone residues
SYSNAME     D-Xylulose-5-phosphate:formaldehyde glycolaldehydetransferase
REACTION    D-Xylulose 5-phosphate + Formaldehyde = Glyceraldehyde 3-phosphate
            + Glycerone
SUBSTRATE   D-Xylulose 5-phosphate
            Hydroxypyruvate
            Formaldehyde
PRODUCT     Glyceraldehyde 3-phosphate
            Glycerone
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein. Not identical with EC 2.2.1.1.
            Also converts hydroxypyruvate and formaldehyde into glycerone
            and CO2
PATHWAY     PATH: MAP00680  Methane metabolism
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00801  R-x(3)-[LIVMTA]-[DENQSTHKF]-x(5,6)-[GSN]-G-H-[PLIVMF]-
                         [GSTA]-x(2)-[LIMC]-[GS]
            PS: PS00802  G-[DEQGSA]-[DN]-G-[PAEQ]-[ST]-[HQ]-x-[PAGM]-[LIVMYAC]-
                         [DEFYW]-x(2)-[STAP]-x(2)-[RGA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.2.1.3
            ExPASy - ENZYME nomenclature database: 2.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.2.1.3
            BRENDA, the Enzyme Database: 2.2.1.3
///
ENTRY       EC 2.2.1.4
NAME        Acetoin--ribose-5-phosphate transaldolase
            1-Deoxy-D-altro-heptulose-7-phosphate synthetase
CLASS       Transferases
            Transferring aldehyde or ketone residues
SYSNAME     3-Hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase
REACTION    3-Hydroxybutan-2-one + D-Ribose 5-phosphate = Acetaldehyde +
            1-Deoxy-D-altro-heptulose 7-phosphate
SUBSTRATE   3-Hydroxybutan-2-one
            D-Ribose 5-phosphate
PRODUCT     Acetaldehyde
            1-Deoxy-D-altro-heptulose 7-phosphate
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.2.1.4
            ExPASy - ENZYME nomenclature database: 2.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.2.1.4
            BRENDA, the Enzyme Database: 2.2.1.4
///
ENTRY       EC 2.3.1.1
NAME        Amino-acid N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-glutamate N-acetyltransferase
REACTION    Acetyl-CoA + L-Glutamate = CoA + N-Acetyl-L-glutamate
SUBSTRATE   Acetyl-CoA
            L-Glutamate
            L-Aspartate
PRODUCT     CoA
            N-Acetyl-L-glutamate
            N-Acetyl-L-aspartate
COMMENT     Also acts with L-aspartate and, more slowly, with some other amino
            acids.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b2818(argA)
            ECE: Z4135(argA)
            ECS: ECs3675
            YPE: YPO1022(argA)
            PMU: PM0828(argA)
            VCH: VC2316
            PAE: PA4402(argJ) PA5204(argA)
            BUC: BU456(argA)
            NME: NMB1876 NMB2005
            NMA: NMA0435(argJ) NMA0580(argA)
            MLO: mll3461
            SME: SMc02450(argJ)
            CCR: CC3066
            BSU: BG10192(argJ)
            BHA: BH2899(argJ)
            SAU: SA0177(argJ)
            SAV: SAV0178(argJ)
            LLA: L0105(argJ)
            CAC: CAC2391(argJ) CAC3020
            MTU: Rv1653(argJ)
            MTC: MT1691
            MLE: ML1407(argJ)
            SYN: sll1883(argJ)
            DRA: DR1704
            AAE: aq_970(argJ)
            TMA: TM1783
            MJA: MJ0186(argJ)
            MTH: MTH182
            AFU: AF1147(argJ)
            SCE: YMR062C(ECM40)
            SPO: SPBC1271.14(spbc1271.14)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.1
            ExPASy - ENZYME nomenclature database: 2.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.1
            BRENDA, the Enzyme Database: 2.3.1.1
///
ENTRY       EC 2.3.1.2
NAME        Imidazole N-acetyltransferase
            Imidazole acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:imidazole N-acetyltransferase
REACTION    Acetyl-CoA + Imidazole = CoA + N-Acetylimidazole
SUBSTRATE   Acetyl-CoA
            Imidazole
            Propanoyl-CoA
PRODUCT     CoA
            N-Acetylimidazole
            N-Propanoylimidazole
COMMENT     Also acts with propanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.2
            ExPASy - ENZYME nomenclature database: 2.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.2
            BRENDA, the Enzyme Database: 2.3.1.2
///
ENTRY       EC 2.3.1.3
NAME        Glucosamine N-acetyltransferase
            Glucosamine acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:D-glucosamine N-acetyltransferase
REACTION    Acetyl-CoA + D-Glucosamine = CoA + N-Acetyl-D-glucosamine
SUBSTRATE   Acetyl-CoA
            D-Glucosamine
PRODUCT     CoA
            N-Acetyl-D-glucosamine
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.3
            ExPASy - ENZYME nomenclature database: 2.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.3
            BRENDA, the Enzyme Database: 2.3.1.3
///
ENTRY       EC 2.3.1.4
NAME        Glucosamine-phosphate N-acetyltransferase
            Phosphoglucosamine transacetylase
            Phosphoglucosamine acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
REACTION    Acetyl-CoA + D-Glucosamine 6-phosphate = CoA +
            N-Acetyl-D-glucosamine 6-phosphate
SUBSTRATE   Acetyl-CoA
            D-Glucosamine 6-phosphate
PRODUCT     CoA
            N-Acetyl-D-glucosamine 6-phosphate
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00530  Aminosugars metabolism
GENES       SCE: YFL017C(GNA1)
            CEL: B0024.12
            DME: CG1969
STRUCTURES  PDB: 1I1D  1I21  1I12  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.4
            ExPASy - ENZYME nomenclature database: 2.3.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.4
            BRENDA, the Enzyme Database: 2.3.1.4
///
ENTRY       EC 2.3.1.5
NAME        Arylamine N-acetyltransferase
            Arylamine acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:arylamine N-acetyltransferase
REACTION    Acetyl-CoA + Arylamine = CoA + N-Acetylarylamine
SUBSTRATE   Acetyl-CoA
            Arylamine
            Aromatic amine
            Serotonin
PRODUCT     CoA
            N-Acetylarylamine
            N-Acetylserotonin
COMMENT     Wide specificity for aromatic amines, including serotonin;
            also catalyses acetyl-transfer between arylamines without CoA.
GENES       MLO: mlr4870
            BSU: BG12404(nat)
            MTU: Rv3566c
            MTC: MT3671
            DME: CG3318(Dat)
            MMU: 97279(Nat1) 97280(Nat4)
            HSA: 10(NAT2) 9(NAT1)
DISEASE     MIM: 108345  Arylamine N-acetyltransferase-1
            MIM: 243400  Arylamine N-acetyltransferase-2
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.5
            ExPASy - ENZYME nomenclature database: 2.3.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.5
            UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.5
            BRENDA, the Enzyme Database: 2.3.1.5
///
ENTRY       EC 2.3.1.6
NAME        Choline O-acetyltransferase
            Choline acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:choline O-acetyltransferase
REACTION    Acetyl-CoA + Choline = CoA + O-Acetylcholine
SUBSTRATE   Acetyl-CoA
            Propanoyl-CoA
            Choline
PRODUCT     CoA
            O-Acetylcholine
COMMENT     Propanoyl-CoA can act, more slowly, in place of acetyl-CoA
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       CEL: cha-1
            DME: CG12345(Cha) CG12345_1(Cha)
            MMU: 88392(Chat)
            HSA: 1103(CHAT)
DISEASE     MIM: 118490  Choline acetyltransferase
MOTIF       PS: PS00439  [LI]-P-x-[LVP]-P-[IVTA]-P-x-[LIVM]-x-[DENQAS]-[ST]-
                         [LIVM]-x(2)-[LY]
            PS: PS00440  R-[FYW]-x-[DA]-[KA]-x(0,1)-[LIVMFY]-x-[LIVMFY](2)-x(3)-
                         [DNS]-[GSA]-x(6)-[DE]-[HS]-x(3)-[DE]-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.6
            ExPASy - ENZYME nomenclature database: 2.3.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.6
            BRENDA, the Enzyme Database: 2.3.1.6
///
ENTRY       EC 2.3.1.7
NAME        Carnitine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:carnitine O-acetyltransferase
REACTION    Acetyl-CoA + Carnitine = CoA + O-Acetylcarnitine
SUBSTRATE   Acetyl-CoA
            Carnitine
            Propanoyl-CoA
            Butanoyl-CoA
PRODUCT     CoA
            O-Acetylcarnitine
            O-Propanoylcarnitine
            O-Butanoylcarnitine
COMMENT     Also acts on propanoyl-CoA and butanoyl-CoA (cf. EC 2.3.1.21 and
            2.3.1.137).
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
GENES       MPN: C09_orf600(cpt2)
            MPU: MYPU_7750(cat)
            SCE: YAR035W(YAT1) YML042W(CAT2)
            CEL: B0395.3
            DME: CG1041 CG5265
            MMU: 109501(Crat)
            HSA: 1384(CRAT)
DISEASE     MIM: 600184  Carnitine acetyltransferase
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00439  [LI]-P-x-[LVP]-P-[IVTA]-P-x-[LIVM]-x-[DENQAS]-[ST]-
                         [LIVM]-x(2)-[LY]
            PS: PS00440  R-[FYW]-x-[DA]-[KA]-x(0,1)-[LIVMFY]-x-[LIVMFY](2)-x(3)-
                         [DNS]-[GSA]-x(6)-[DE]-[HS]-x(3)-[DE]-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.7
            ExPASy - ENZYME nomenclature database: 2.3.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.7
            BRENDA, the Enzyme Database: 2.3.1.7
///
ENTRY       EC 2.3.1.8
NAME        Phosphate acetyltransferase
            Phosphotransacetylase
            Phosphoacylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:orthophosphate acetyltransferase
REACTION    Acetyl-CoA + Orthophosphate = CoA + Acetyl phosphate
SUBSTRATE   Acetyl-CoA
            Orthophosphate
PRODUCT     CoA
            Acetyl phosphate
COMMENT     Also acts with other short-chain acyl-CoA's.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b2297(PTA)
            ECE: Z3559(pta)
            ECS: ECs3181
            YPE: YPO2567(pta)
            HIN: HI1203(PTA)
            PMU: PM0705(pta)
            VCH: VC1097
            PAE: PA0835(pta)
            BUC: BU176(pta)
            NME: NMB0631
            NMA: NMA0841
            HPY: HP0905(pta)
            HPJ: jhp0841
            CJE: Cj0688(pta)
            RPR: RP109(pta)
            SME: SMb21532(pta)
            BSU: BG10634(pta)
            BHA: BH3823(pta)
            SAU: SA0545(pta)
            SAV: SAV0577
            LLA: L107797(pta)
            SPY: SPy1128(pta)
            SPN: SP1100
            SPR: spr1007(pta)
            CAC: CAC1742(pta) CAC3076(ptb)
            MGE: MG299(PTA)
            MPN: A05_orf320(pta)
            MPU: MYPU_2370(pta)
            UUR: UU066(pta)
            MTU: Rv0408(pta)
            MTC: MT0421
            BBU: BB0589(pta)
            TPA: TP0094
            SYN: slr2132(pta)
            DRA: DR0073
            TMA: TM1130
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.8
            ExPASy - ENZYME nomenclature database: 2.3.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.8
            UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.8
            BRENDA, the Enzyme Database: 2.3.1.8
///
ENTRY       EC 2.3.1.9
NAME        Acetyl-CoA C-acetyltransferase
            Acetoacetyl-CoA thiolase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:acetyl-CoA C-acetyltransferase
REACTION    Acetyl-CoA + Acetyl-CoA = CoA + Acetoacetyl-CoA
SUBSTRATE   Acetyl-CoA
PRODUCT     CoA
            Acetoacetyl-CoA
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1397 b2224(atoB) b2844(yqeF)
            ECE: Z4164(yqeF)
            ECS: ECs3701
            HIN: HI0771(atob)
            VCH: VCA0690
            PAE: PA2001(atoB) PA2553 PA3454 PA3589 PA3925
            HPY: HP0690(fadA)
            HPJ: jhp0638
            RPR: RP737(fadA)
            MLO: mlr3847
            SME: SMc03879(phbA)
            CCR: CC0510 CC0894 CC3462
            BSU: BG11319(mmgA) BG13063(yhfS)
            BHA: BH0205 BH1997 BH2029 BH3801(mmgA)
            SAU: SA0342 SA0534(vraB)
            SAV: SAV0343(thlA)
            LLA: L11745(thiL) L25946(fadA)
            SPY: SPy0140 SPy1637(atoB)
            CAC: CAC2873
            MTU: Rv1323(fadA4)
            MTC: MT1365
            MLE: ML1158(fadA4)
            BBU: BB0109(fadA)
            SYN: slr1993(thl)
            DRA: DR1072 DR1428 DR1960 DR2480 DRA0053
            TAC: Ta0582
            TVO: TVG0643747
            APE: APE2108
            SSO: SSO2377(acaB-4)
            STO: ST0514
            SCE: YPL028W(ERG10)
            SPO: SPBC215.09C(spbc215.09c)
            CEL: F53A2.7 T02G5.4 T02G5.7 T02G5.8
            DME: CG10932 CG9149
            HSA: 38(ACAT1) 39(ACAT2)
DISEASE     MIM: 203750  Acetyl-Coenzyme A acetyltransferase-1 (acetoacetyl
                         Coenzyme A
MOTIF       PS: PS00098  [LIVM]-[NST]-x(2)-C-[SAGLI]-[ST]-[SAG]-[LIVMFYNS]-x-
                         [STAG]-[LIVM]-x(6)-[LIVM]
            PS: PS00099  [AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-x-[AG]-x-
                         [AG]-x-[AG]-x-[SAG]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00737  N-x(2)-G-G-x-[LIVM]-[SA]-x-G-H-P-x-[GA]-x-[ST]-G
STRUCTURES  PDB: 1DLV  1DLU  1QFL  1DM3  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.9
            ExPASy - ENZYME nomenclature database: 2.3.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.9
            UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.9
            BRENDA, the Enzyme Database: 2.3.1.9
            SCOP (Structural Classification of Proteins): 2.3.1.9
///
ENTRY       EC 2.3.1.10
NAME        Hydrogen-sulfide S-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:hydrogen-sulfide S-acetyltransferase
REACTION    Acetyl-CoA + Hydrogen-sulfide = CoA + Thioacetate
SUBSTRATE   Acetyl-CoA
            Hydrogen-sulfide
PRODUCT     CoA
            Thioacetate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.10
            ExPASy - ENZYME nomenclature database: 2.3.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.10
            BRENDA, the Enzyme Database: 2.3.1.10
///
ENTRY       EC 2.3.1.11
NAME        Thioethanolamine S-acetyltransferase
            Thioltransacetylase B
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:thioethanolamine S-acetyltransferase
REACTION    Acetyl-CoA + Thioethanolamine = CoA + S-Acetylthioethanolamine
SUBSTRATE   Acetyl-CoA
            Thioethanolamine
PRODUCT     CoA
            S-Acetylthioethanolamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.11
            ExPASy - ENZYME nomenclature database: 2.3.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.11
            BRENDA, the Enzyme Database: 2.3.1.11
///
ENTRY       EC 2.3.1.12
NAME        Dihydrolipoamide S-acetyltransferase
            Lipoate acetyltransferase
            Thioltransacetylase A
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:dihydrolipoamide S-acetyltransferase
REACTION    Acetyl-CoA + Dihydrolipoamide = CoA + S-Acetyldihydrolipoamide
SUBSTRATE   Acetyl-CoA
            Dihydrolipoamide
PRODUCT     CoA
            S-Acetyldihydrolipoamide
COMMENT     A lipoyl-protein; component of the multienzyme pyruvate
            dehydrogenase complex.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0115(aceF)
            ECE: Z0125(aceF)
            ECS: ECs0119
            YPE: YPO3418(aceF)
            HIN: HI1232(aceF)
            PMU: PM0894(aceF)
            XFA: XF0869
            VCH: VC2413
            PAE: PA2249(bkdB) PA3415 PA5016(aceF)
            BUC: BU206(aceF)
            NME: NMB1342
            NMA: NMA1555(aceF)
            RPR: RP530(pdhC)
            RCO: RC0764(pdhC)
            MLO: mll3627 mll4471 mlr0385
            SME: SMc01032(pdhB)
            CCR: CC1729
            BSU: BG10209(pdhC) BG12560(acoC)
            BHA: BH0215 BH0778 BH1824(acoC) BH2653(pdhC)
            SAU: SA0945(pdhC)
            SAV: SAV1079(pdhC)
            LLA: L0035(pdhC)
            SPY: SPy1029(acoC)
            SPN: SP1162
            SPR: spr1049(acoC)
            MGE: MG272(pdhC)
            MPN: F11_orf402(pdhC)
            MPU: MYPU_7620(pdhC)
            MTU: Rv2495c(pdhC)
            MTC: MT2570
            CTR: CT247
            CMU: TC0518
            CPN: CPn0306
            CPA: CP0452
            CPJ: pdhC
            SYN: sll1841(odhB)
            DRA: DR0032 DR0256
            HAL: VNG2219G(dsa)
            TAC: Ta1436
            TVO: TVG0103933
            APE: APE1671
            SSO: SSO1529(pdhC) SSO1530(pdhC)
            SCE: YNL071W(LAT1)
            SPO: SPCC1259.09C(spcc1259.09c) SPCC794.07(spcc794.07)
            ATH: At1g34430(F12K21.24) At1g54220(F20D21.4) At3g13930(MDC16.18)
                 At3g25860(MPE11.6) At3g52200(T25B15.141)
            CEL: C30H6.7 F23B12.5 ZK669.4
            DME: CG5261 CG5261_1 CG5599
            HSA: 1737(DLAT) 8050(PDX1)
MOTIF       PS: PS00189  [GN]-x(2)-[LIVF]-x(5)-[LIVFC]-x(2)-[LIVFA]-x(3)-K-
                         [STAIV]-[STAVQDN]-x(2)-[LIVMFS]-x(5)-[GCN]-x-[LIVMFY]
STRUCTURES  PDB: 1DPD  1EAA  1EAB  1EAC  1DPC  1EAE  1EAF  1FYC  1IYU  1IYV  
                 1LAB  1DPB  2PDD  2PDE  1EAD  1LAC  1B5S  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.12
            ExPASy - ENZYME nomenclature database: 2.3.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.12
            BRENDA, the Enzyme Database: 2.3.1.12
            SCOP (Structural Classification of Proteins): 2.3.1.12
///
ENTRY       EC 2.3.1.13
NAME        Glycine N-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:glycine N-acyltransferase
REACTION    Acyl-CoA + Glycine = CoA + N-Acylglycine
SUBSTRATE   Acyl-CoA
            Glycine
PRODUCT     CoA
            N-Acylglycine
COMMENT     The CoA derivatives of a number of aliphatic and aromatic acids,
            but not phenylacetyl-CoA or indoleacetyl-CoA, can act as donor.
            Not identical with EC 2.3.1.68 or 2.3.1.71.
GENES       HSA: 10249(GLYAT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.13
            ExPASy - ENZYME nomenclature database: 2.3.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.13
            BRENDA, the Enzyme Database: 2.3.1.13
///
ENTRY       EC 2.3.1.14
NAME        Glutamine N-phenylacetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
REACTION    Phenylacetyl-CoA + L-Glutamine = CoA +
            alpha-N-Phenylacetyl-L-glutamine
SUBSTRATE   Phenylacetyl-CoA
            L-Glutamine
PRODUCT     CoA
            alpha-N-Phenylacetyl-L-glutamine
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.14
            ExPASy - ENZYME nomenclature database: 2.3.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.14
            BRENDA, the Enzyme Database: 2.3.1.14
///
ENTRY       EC 2.3.1.15
NAME        Glycerol-3-phosphate O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:sn-glycerol-3-phosphate O-acyltransferase
REACTION    Acyl-CoA + sn-Glycerol 3-phosphate = CoA +
            1-Acyl-sn-glycerol 3-phosphate
SUBSTRATE   sn-Glycerol 3-phosphate
            Acyl-CoA
            Acyl-[acyl-carrier protein]
PRODUCT     CoA
            1-Acyl-sn-glycerol 3-phosphate
COMMENT     Acyl-[acyl-carrier protein] can also act as acyl donor. The enzyme
            acts only on derivatives of fatty acids of chain length above C10.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b4041(plsB)
            ECE: Z5640(plsB)
            ECS: ECs5024
            YPE: YPO0312(plsB)
            HIN: HI0748(plsB)
            PMU: PM1182(plsB)
            XFA: XF1031
            VCH: VC0093
            PAE: PA3673(plsB)
            MTU: Rv1551(plsB1) Rv2482c(plsB2)
            MTC: MT1601 MT2555
            MLE: ML1246(plsB)
            CTR: CT807
            CMU: TC0192
            CPN: CPn0958
            CPA: CP0902
            CPJ: plsB
            BBU: BB0327
            CEL: F08F3.2
            MMU: 109162(Gpam)
            HSA: 8443(GNPAT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.15
            ExPASy - ENZYME nomenclature database: 2.3.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.15
            BRENDA, the Enzyme Database: 2.3.1.15
///
ENTRY       EC 2.3.1.16
NAME        Acetyl-CoA C-acyltransferase
            beta-Ketothiolase
            3-Ketoacyl-CoA thiolase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:acetyl-CoA C-acyltransferase
REACTION    Acyl-CoA + Acetyl-CoA = CoA + 3-Oxoacyl-CoA
SUBSTRATE   Acyl-CoA
            Acetyl-CoA
PRODUCT     CoA
            3-Oxoacyl-CoA
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00360  Phenylalanine metabolism
GENES       ECO: b2342 b3845(fadA)
            ECE: Z3605 Z5366(fadA)
            ECS: ECs3225 ECs4773
            YPE: YPO2746 YPO3767(fadA)
            VCH: VC1046 VC2759
            PAE: PA0228(pcaF) PA1736 PA2940 PA3013(foaB) PA4785
            MLO: mll4180 mlr5628 mlr7614
            SME: SMc00966 SMc02228(fadA)
            CCR: CC0077 CC0779 CC1111 CC1432 CC2407
            BSU: BG14023(yusK)
            BHA: BH3487
            SAU: SA0223
            SAV: SAV0224(mmgA)
            MTU: Rv0243(fadA2) Rv0859(fadA) Rv1074c(fadA3) Rv3523
                 Rv3546(fadA5) Rv3556c(fadA6)
            MTC: MT0257 MT0882 MT1104 MT2860 MT3623 MT3650
            MLE: ML2162(fadA) ML2564(fadA2)
            MJA: MJ1549
            MTH: MTH793
            AFU: AF0018(acaB-1) AF0034(acaB-2) AF0133(acaB-3) AF0134(acaB-4)
                 AF0201(acaB-5) AF0202(acaB-6) AF0283(acaB-7) AF0438(acaB-8)
                 AF0967(acaB-9) AF0968(acaB-10) AF1028(fadA-1) AF1197(fadA-2)
                 AF1291(acaB-11) AF2243(fadA-3) AF2416(acaB-12)
            HAL: VNG0678G(acaB1) VNG0931G(acaB2) VNG2063G(aca)
            TAC: Ta0030 Ta0296 Ta1456
            TVO: TVG0067506 TVG0142182 TVG1370641
            PHO: PH0676
            PAB: PAB0907(acaB)
            APE: APE0929 APE1872 APE2382 APE2384
            SSO: SSO2061(acaB-2) SSO2062(acaB-3) SSO2496(acaB-5)
                 SSO2625(acaB-7) SSO2697(acaB-8) SSO2874(acaB-9)
            STO: ST0079 ST0096 ST1350
            SCE: YIL160C(POT1)
            DME: CG4581(Thiolase) CG4600
            HSA: 10449(ACAA2) 30(ACAA1) 3032(HADHB)
DISEASE     MIM: 143450  Hydroxyacyl-Coenzyme A
                         dehydrogenase/3-ketoacyl-Coenzyme A thiolase
            MIM: 604054  Acetyl-Coenzyme A acyltransferase 1 (peroxisomal
                         3-oxoacyl-Coenzyme A
MOTIF       PS: PS00098  [LIVM]-[NST]-x(2)-C-[SAGLI]-[ST]-[SAG]-[LIVMFYNS]-x-
                         [STAG]-[LIVM]-x(6)-[LIVM]
            PS: PS00099  [AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-x-[AG]-x-
                         [AG]-x-[AG]-x-[SAG]
            PS: PS00737  N-x(2)-G-G-x-[LIVM]-[SA]-x-G-H-P-x-[GA]-x-[ST]-G
STRUCTURES  PDB: 1AFY  1PXT  1AFW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.16
            ExPASy - ENZYME nomenclature database: 2.3.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.16
            BRENDA, the Enzyme Database: 2.3.1.16
            SCOP (Structural Classification of Proteins): 2.3.1.16
///
ENTRY       EC 2.3.1.17
NAME        Aspartate N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-aspartate N-acetyltransferase
REACTION    Acetyl-CoA + L-Aspartate = CoA + N-Acetyl-L-aspartate
SUBSTRATE   Acetyl-CoA
            L-Aspartate
PRODUCT     CoA
            N-Acetyl-L-aspartate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.17
            ExPASy - ENZYME nomenclature database: 2.3.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.17
            BRENDA, the Enzyme Database: 2.3.1.17
///
ENTRY       EC 2.3.1.18
NAME        Galactoside O-acetyltransferase
            Thiogalactoside acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:beta-D-galactoside 6-acetyltransferase
REACTION    Acetyl-CoA + beta-D-Galactoside = CoA +
            6-Acetyl-beta-D-galactoside
SUBSTRATE   Acetyl-CoA
            beta-D-Galactoside
            Thiogalactoside
            Phenylgalactoside
PRODUCT     CoA
            6-Acetyl-beta-D-galactoside
COMMENT     Acts on thiogalactosides and phenylgalactoside.
GENES       ECO: b0342(lacA)
            ECE: Z0438(lacA)
            ECS: ECs0395
            LLA: L0026(thgA)
            CAC: CAC2692
            MJA: MJ1064(lacA)
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.18
            ExPASy - ENZYME nomenclature database: 2.3.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.18
            BRENDA, the Enzyme Database: 2.3.1.18
///
ENTRY       EC 2.3.1.19
NAME        Phosphate butyryltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Butanoyl-CoA:orthophosphate butanoyltransferase
REACTION    Butanoyl-CoA + Orthophosphate = CoA + Butanoylphosphate
SUBSTRATE   Butanoyl-CoA
            Orthophosphate
PRODUCT     CoA
            Butanoylphosphate
PATHWAY     PATH: MAP00650  Butanoate metabolism
GENES       BSU: BG11722(ptb)
            TMA: TM1755
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.19
            ExPASy - ENZYME nomenclature database: 2.3.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.19
            BRENDA, the Enzyme Database: 2.3.1.19
///
ENTRY       EC 2.3.1.20
NAME        Diacylglycerol O-acyltransferase
            Diglyceride acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1,2-diacylglycerol O-acyltransferase
REACTION    Acyl-CoA + 1,2-Diacylglycerol = CoA + Triacylglycerol
SUBSTRATE   Acyl-CoA
            1,2-Diacylglycerol
            Palmitoyl-CoA
PRODUCT     CoA
            Triacylglycerol
COMMENT     Palmitoyl-CoA and other long-chain acyl-CoA's can act as donors.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       HSA: 8694(DGAT)
DISEASE     MIM: 604900  Diacylglycerol O-acyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.20
            ExPASy - ENZYME nomenclature database: 2.3.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.20
            BRENDA, the Enzyme Database: 2.3.1.20
///
ENTRY       EC 2.3.1.21
NAME        Carnitine O-palmitoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:L-carnitine O-palmitoyltransferase
REACTION    Palmitoyl-CoA + L-Carnitine = CoA + L-Palmitoylcarnitine
SUBSTRATE   Palmitoyl-CoA
            L-Carnitine
PRODUCT     CoA
            L-Palmitoylcarnitine
COMMENT     Broad specificity to acyl group, over the range C8 to C18; optimal
            activity with palmitoyl-CoA. cf. EC 2.3.1.7 and 2.3.1.137.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       CEL: R07H5.2
            DME: CG12891(CPTI) CG12891_1(CPTI) CG2107
            HSA: 1374(CPT1A) 1375(CPT1B) 1376(CPT2)
DISEASE     MIM: 600528  Carnitine palmitoyltransferase I, liver
            MIM: 600650  Carnitine palmitoyltransferase II
MOTIF       PS: PS00439  [LI]-P-x-[LVP]-P-[IVTA]-P-x-[LIVM]-x-[DENQAS]-[ST]-
                         [LIVM]-x(2)-[LY]
            PS: PS00440  R-[FYW]-x-[DA]-[KA]-x(0,1)-[LIVMFY]-x-[LIVMFY](2)-x(3)-
                         [DNS]-[GSA]-x(6)-[DE]-[HS]-x(3)-[DE]-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.21
            ExPASy - ENZYME nomenclature database: 2.3.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.21
            BRENDA, the Enzyme Database: 2.3.1.21
///
ENTRY       EC 2.3.1.22
NAME        2-Acylglycerol O-acyltransferase
            Acylglycerol palmitoyltransferase
            Monoglyceride acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:2-acylglycerol O-acyltransferase
REACTION    Acyl-CoA + 2-Acylglycerol = CoA + Diacylglycerol
SUBSTRATE   Acyl-CoA
            2-Acylglycerol
            Palmitoyl-CoA
PRODUCT     CoA
            Diacylglycerol
COMMENT     Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and
            other long-chain acyl-CoA's can act as donors. The sn-1 position
            and the sn-3 position are both acylated, at about the same rate.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.22
            ExPASy - ENZYME nomenclature database: 2.3.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.22
            BRENDA, the Enzyme Database: 2.3.1.22
///
ENTRY       EC 2.3.1.23
NAME        1-Acylglycerophosphocholine O-acyltransferase
            Lysolecithin acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
REACTION    Acyl-CoA + 1-Acyl-sn-glycero-3-phosphocholine = CoA +
            1,2-Diacyl-sn-glycero-3-phosphocholine
SUBSTRATE   Acyl-CoA
            1-Acyl-sn-glycero-3-phosphocholine
            1-Acyl-sn-glycero-3-phosphoinositol
PRODUCT     CoA
            1,2-Diacyl-sn-glycero-3-phosphocholine
            1,2-Diacyl-sn-glycero-3-phosphoinositol
COMMENT     Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-
            -sn-glycero-3-phosphoinositol can also act as acceptor.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.23
            ExPASy - ENZYME nomenclature database: 2.3.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.23
            BRENDA, the Enzyme Database: 2.3.1.23
///
ENTRY       EC 2.3.1.24
NAME        Sphingosine N-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:sphingosine N-acyltransferase
REACTION    Acyl-CoA + Sphingosine = CoA + N-Acylsphingosine
SUBSTRATE   Acyl-CoA
            Sphingosine
PRODUCT     CoA
            N-Acylsphingosine
COMMENT     Acts on sphingosine or its 2-epimer.
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
            PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.24
            ExPASy - ENZYME nomenclature database: 2.3.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.24
            BRENDA, the Enzyme Database: 2.3.1.24
///
ENTRY       EC 2.3.1.25
NAME        Plasmalogen synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine
            $ 2-O-acyltransferase
REACTION    Acyl-CoA + 1-O-Alk-1-enyl-glycero-3-phosphocholine = CoA +
            $ Plasmenylcholine
SUBSTRATE   Acyl-CoA
            1-O-Alk-1-enyl-glycero-3-phosphocholine
PRODUCT     CoA
            Plasmenylcholine
PATHWAY     PATH: MAP00580  Phospholipid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.25
            ExPASy - ENZYME nomenclature database: 2.3.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.25
            BRENDA, the Enzyme Database: 2.3.1.25
///
ENTRY       EC 2.3.1.26
NAME        Sterol O-acyltransferase
            Cholesterol acyltransferase
            Sterol-ester synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:cholesterol O-acyltransferase
REACTION    Acyl-CoA + Cholesterol = CoA + Cholesterol ester
SUBSTRATE   Acyl-CoA
            Cholesterol
PRODUCT     CoA
            Cholesterol ester
COMMENT     The animal enzyme is highly specific for transfer of acyl groups
            with a single cis double bond 9 carbon atoms distant from the
            carboxyl group.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
GENES       SCE: YCR048W(ARE1) YNR019W(ARE2)
            SPO: SPAC13G7.05(spac13g7.05)
            MMU: 104665(Acact)
            HSA: 6646(SOAT1)
DISEASE     MIM: 102642  Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.26
            ExPASy - ENZYME nomenclature database: 2.3.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.26
            BRENDA, the Enzyme Database: 2.3.1.26
///
ENTRY       EC 2.3.1.27
NAME        Cortisol O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:cortisol O-acetyltransferase
REACTION    Acetyl-CoA + Cortisol = CoA + Cortisol 21-acetate
SUBSTRATE   Acetyl-CoA
            Cortisol
PRODUCT     CoA
            Cortisol 21-acetate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.27
            ExPASy - ENZYME nomenclature database: 2.3.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.27
            BRENDA, the Enzyme Database: 2.3.1.27
///
ENTRY       EC 2.3.1.28
NAME        Chloramphenicol O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:chloramphenicol O3-acetyltransferase
REACTION    Acetyl-CoA + Chloramphenicol = CoA + Chloramphenicol 3-acetate
SUBSTRATE   Acetyl-CoA
            Chloramphenicol
PRODUCT     CoA
            Chloramphenicol 3-acetate
GENES       VCH: VCA0300
            PAE: PA0706(cat)
            MLO: mll2311
            DRA: DR2303
MOTIF       PS: PS00100  Q-[LIV]-H-H-[SA]-x(2)-D-G-[FY]-H
            PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
STRUCTURES  PDB: 1CIA  1CLA  1NOC  1QCA  2CLA  3CLA  4CLA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.28
            ExPASy - ENZYME nomenclature database: 2.3.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.28
            BRENDA, the Enzyme Database: 2.3.1.28
            SCOP (Structural Classification of Proteins): 2.3.1.28
///
ENTRY       EC 2.3.1.29
NAME        Glycine C-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:glycine C-acetyltransferase
REACTION    Acetyl-CoA + Glycine = CoA + 2-Amino-3-oxobutanoate
SUBSTRATE   Acetyl-CoA
            Glycine
PRODUCT     CoA
            2-Amino-3-oxobutanoate
COFACTOR    Pyridoxal phosphate
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b3617(kbl)
            ECE: Z5044(kbl)
            ECS: ECs4495
            YPE: YPO0059(kbl)
            VCH: VCA0886
            MLO: mll9204 mlr8297
            SME: SMc01565(kbl)
            BSU: BG12610(kbl)
            SAU: SA0508
            SAV: SAV0539
            DME: CG10361
            HSA: 23464(GCAT)
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
STRUCTURES  PDB: 1FC4  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.29
            ExPASy - ENZYME nomenclature database: 2.3.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.29
            BRENDA, the Enzyme Database: 2.3.1.29
///
ENTRY       EC 2.3.1.30
NAME        Serine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-serine O-acetyltransferase
REACTION    Acetyl-CoA + L-Serine = CoA + O-Acetyl-L-serine
SUBSTRATE   Acetyl-CoA
            L-Serine
PRODUCT     CoA
            O-Acetyl-L-serine
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b3607(cysE)
            ECE: Z5034(cysE)
            ECS: ECs4485
            YPE: YPO0070(cysE)
            HIN: HI0606(cysE)
            PMU: PM1430(cysE)
            VCH: VC2649
            PAE: PA3816(cysE)
            BUC: BU054(cysE)
            NME: NMB0560
            NMA: NMA0742(cysE)
            HPY: HP1210(cysE)
            HPJ: jhp1133
            CJE: Cj0763c(cysE)
            MLO: mlr0175
            SME: SMc02113(cysE)
            CCR: CC2651
            BSU: BG10155(cysE)
            BHA: BH0110(cysE)
            SAU: SA0487(cysE)
            SAV: SAV0519(cysE)
            LLA: L0087(cysE)
            SPY: SPy1944(cysE)
            SPN: SP0589
            SPR: spr0517(cysE)
            CAC: CAC0687(cysE)
            MTU: Rv2335(cysE)
            MTC: MT2398
            MLE: ML0838(cysE)
            SYN: slr1348(cysE)
            TMA: TM0666
            HAL: VNG1481G(sat)
            SPO: SPAC1039.08(spac1039.08)
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.30
            ExPASy - ENZYME nomenclature database: 2.3.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.30
            BRENDA, the Enzyme Database: 2.3.1.30
///
ENTRY       EC 2.3.1.31
NAME        Homoserine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-homoserine O-acetyltransferase
REACTION    Acetyl-CoA + L-Homoserine = CoA + O-Acetyl-L-homoserine
SUBSTRATE   Acetyl-CoA
            L-Homoserine
PRODUCT     CoA
            O-Acetyl-L-homoserine
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       HIN: HI1263
            PMU: PM0866(met2)
            XFA: XF2465
            PAE: PA0390(metX)
            NME: NMB0940
            NMA: NMA1136(metX)
            MLO: mlr3538
            SME: SMc01809
            CCR: CC0525
            SAU: SA0011
            MTU: Rv3341(metA)
            MTC: MT3444
            MLE: ML0682(metA)
            DRA: DR0872
            MTH: MTH1820
            HAL: VNG2420G(metA)
            SCE: YNL277W(MET2)
            SPO: MET6(met6) SPBC106.17C(spbc106.17c)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.31
            ExPASy - ENZYME nomenclature database: 2.3.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.31
            BRENDA, the Enzyme Database: 2.3.1.31
///
ENTRY       EC 2.3.1.32
NAME        Lysine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-phosphate:L-lysine N6-acetyltransferase
REACTION    Acetyl phosphate + L-Lysine = Orthophosphate + N6-Acetyl-L-lysine
SUBSTRATE   Acetyl phosphate
            L-Lysine
PRODUCT     Orthophosphate
            N6-Acetyl-L-lysine
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.32
            ExPASy - ENZYME nomenclature database: 2.3.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.32
            BRENDA, the Enzyme Database: 2.3.1.32
///
ENTRY       EC 2.3.1.33
NAME        Histidine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-histidine N-acetyltransferase
REACTION    Acetyl-CoA + L-Histidine = CoA + N-Acetyl-L-histidine
SUBSTRATE   Acetyl-CoA
            L-Histidine
PRODUCT     CoA
            N-Acetyl-L-histidine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.33
            ExPASy - ENZYME nomenclature database: 2.3.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.33
            BRENDA, the Enzyme Database: 2.3.1.33
///
ENTRY       EC 2.3.1.34
NAME        D-Tryptophan N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:D-tryptophan N-acetyltransferase
REACTION    Acetyl-CoA + D-Tryptophan = CoA + N-Acetyl-D-tryptophan
SUBSTRATE   Acetyl-CoA
            D-Tryptophan
PRODUCT     CoA
            N-Acetyl-D-tryptophan
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.34
            ExPASy - ENZYME nomenclature database: 2.3.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.34
            BRENDA, the Enzyme Database: 2.3.1.34
///
ENTRY       EC 2.3.1.35
NAME        Glutamate N-acetyltransferase
            Ornithine transacetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     N2-Acetyl-L-ornithine:L-glutamate N-acetyltransferase
REACTION    N2-Acetyl-L-ornithine + L-Glutamate = L-Ornithine +
            N-Acetyl-L-glutamate
SUBSTRATE   N2-Acetyl-L-ornithine
            L-Glutamate
PRODUCT     L-Ornithine
            N-Acetyl-L-glutamate
COMMENT     Also has some hydrolytic activity on acetyl-L-ornithine, but rate
            is 1% of that of transferase activity.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       PAE: PA4402(argJ)
            NME: NMB2005
            NMA: NMA0435(argJ)
            MLO: mll3461
            SME: SMc02450(argJ)
            CCR: CC3066
            BSU: BG10192(argJ)
            BHA: BH2899(argJ)
            SAU: SA0177(argJ)
            SAV: SAV0178(argJ)
            LLA: L0105(argJ)
            CAC: CAC2391(argJ) CAC3020
            MTU: Rv1653(argJ)
            MTC: MT1691
            MLE: ML1407(argJ)
            SYN: sll1883(argJ)
            DRA: DR1704
            AAE: aq_970(argJ)
            TMA: TM1783
            MJA: MJ0186(argJ)
            MTH: MTH182
            AFU: AF1147(argJ)
            SCE: YMR062C(ECM40)
            SPO: SPBC1271.14(spbc1271.14)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.35
            ExPASy - ENZYME nomenclature database: 2.3.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.35
            BRENDA, the Enzyme Database: 2.3.1.35
///
ENTRY       EC 2.3.1.36
NAME        D-Amino-acid N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:D-amino-acid N-acetyltransferase
REACTION    Acetyl-CoA + a D-Amino acid = CoA + an N-Acetyl-D-amino-acid
SUBSTRATE   Acetyl-CoA
            D-Amino acid
PRODUCT     CoA
            N-Acetyl-D-amino-acid
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.36
            ExPASy - ENZYME nomenclature database: 2.3.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.36
            BRENDA, the Enzyme Database: 2.3.1.36
///
ENTRY       EC 2.3.1.37
NAME        5-Aminolevulinate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating)
REACTION    Succinyl-CoA + Glycine = 5-Aminolevulinate + CoA + CO2
SUBSTRATE   Succinyl-CoA
            Glycine
PRODUCT     5-Aminolevulinate
            CoA
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The enzyme in erythrocytes is
            genetically distinct from that in other tissues.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       RPR: RP841(hemA)
            RCO: RC1303(hemA)
            MLO: mll5695 mll6600
            SME: SMc03104(hemA)
            CCR: CC1355
            SCE: YDR232W(HEM1)
            SPO: SPAC2F3.09(spac2f3.09)
            DME: CG3017(Alas)
            MMU: 87990(Alas2)
            HSA: 211(ALAS1) 212(ALAS2)
DISEASE     MIM: 125290  Aminolevulinate, delta-, synthase-1
            MIM: 301300  Aminolevulinate, delta-, synthase-2
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.37
            ExPASy - ENZYME nomenclature database: 2.3.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.37
            BRENDA, the Enzyme Database: 2.3.1.37
///
ENTRY       EC 2.3.1.38
NAME        [Acyl-carrier-protein] S-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase
REACTION    Acetyl-CoA + [Acyl-carrier protein] = CoA +
            Acetyl-[acyl-carrier protein]
SUBSTRATE   Acetyl-CoA
            Acyl-carrier protein
PRODUCT     CoA
            Acetyl-[acyl-carrier protein]
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       SCE: YKL182W(FAS1)
            SPO: SPAC926.09C(spac926.09c)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.38
            ExPASy - ENZYME nomenclature database: 2.3.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.38
            BRENDA, the Enzyme Database: 2.3.1.38
///
ENTRY       EC 2.3.1.39
NAME        [Acyl-carrier-protein] S-malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase
REACTION    Malonyl-CoA + [Acyl-carrier protein] = CoA +
            Malonyl-[acyl-carrier protein]
SUBSTRATE   Malonyl-CoA
            Acyl-carrier protein
PRODUCT     CoA
            Malonyl-[acyl-carrier protein]
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b1092(fabD)
            ECE: Z1731(fabD)
            ECS: ECs1470
            YPE: YPO1598(fabD)
            HIN: HI0156(fabD)
            PMU: PM1915(fabD)
            XFA: XF0670
            VCH: VC2022
            PAE: PA0214 PA2968(fabD)
            NME: NMB1918
            NMA: NMA0536(fabD)
            HPY: HP0090(fabD)
            HPJ: jhp0083
            CJE: Cj0116(fabD)
            RPR: RP735(fabD)
            RCO: RC1116(fabD)
            MLO: mlr7849
            SME: SMc00571(fabD)
            CCR: CC1674
            BSU: BG11836(fabD)
            BHA: BH2492(fabD)
            SAU: SA1073(fabD)
            SAV: SAV1217(fabD)
            LLA: L0184(fabD)
            SPY: SPy1750(fabD)
            SPN: SP0420
            SPR: spr0380(fabD)
            CAC: CAC3575(fabD)
            MTU: Rv2243(fabD)
            MTC: MT2303
            MLE: ML1653(fabD)
            CTR: CT238
            CMU: TC0509
            CPN: CPn0297
            CPA: CP0461
            CPJ: fabD
            SYN: slr2023(fabD)
            DRA: DR1945
            AAE: aq_892(fabD)
            TMA: TM0798
            SCE: YKL182W(FAS1)
            SPO: SPAC11G7.05C(spac11g7.05c) SPAC926.09C(spac926.09c)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.39
            ExPASy - ENZYME nomenclature database: 2.3.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.39
            BRENDA, the Enzyme Database: 2.3.1.39
///
ENTRY       EC 2.3.1.40
NAME        Acyl-[acyl-carrier protein]--phospholipid O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-[acyl-carrier-protein]:O-(2-acyl-sn-glycero-3-phospho)-
            $ethanolamine O-acyltransferase
REACTION    Acyl-[acyl-carrier protein] +
            O-(2-Acyl-sn-glycero-3-phospho)-ethanolamine =
            [Acyl-carrier protein] +
            O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine
SUBSTRATE   Acyl-[acyl-carrier protein]
            O-(2-Acyl-sn-glycero-3-phospho)-ethanolamine
PRODUCT     Acyl-carrier protein
            O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.40
            ExPASy - ENZYME nomenclature database: 2.3.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.40
            BRENDA, the Enzyme Database: 2.3.1.40
///
ENTRY       EC 2.3.1.41
NAME        3-Oxoacyl-[acyl-carrier-protein] synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein]
            C-acyltransferase (decarboxylating)
REACTION    Acyl-[acyl-carrier protein] + Malonyl-[acyl-carrier protein] =
            3-Oxoacyl-[acyl-carrier protein] + CO2 + [Acyl-carrier protein]
SUBSTRATE   Acyl-[acyl-carrier protein]
            Malonyl-[acyl-carrier protein]
PRODUCT     3-Oxoacyl-[acyl-carrier protein]
            CO2
            Acyl-carrier protein
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b1091(fabH) b1095(fabF) b2323(fabB)
            ECE: Z1730(fabH) Z1734(fabF) Z3586(fabB) Z4866
            ECS: ECs1469 ECs1473 ECs3207 ECs4341
            YPE: YPO1428 YPO1597(fabH) YPO1601(fabF) YPO1977 YPO2757(fabB)
            HIN: HI0157(fabH) HI1533(fabB)
            PMU: PM0339(fabB) PM1914(fabH)
            XFA: XF0673 XF1817 XF1970
            VCH: VC2019 VC2023 VCA0751
            PAE: PA0999(fabH1) PA1373(fabF2) PA1609(fabB) PA2965(fabF1)
                 PA3333(fabH2)
            BUC: BU092(fabB)
            NME: NMB0219 NMB1703 NMB1916
            NMA: NMA0044(fabF) NMA0538(fabH) NMA1957(fabF2)
            HPY: HP0202(fabH) HP0558(fabF)
            HPJ: jhp0188 jhp0505
            CJE: Cj0328c(fabH) Cj0442(fabF) Cj1303(fabH2)
            RPR: RP764(fabF) RP772(fabH)
            RCO: RC1186(fabF) RC1202(fabH)
            MLO: mll5566 mll5827 mll9094 mlr1177 mlr2832 mlr7852 mlr8424
            SME: SMc00327(fabB) SMc00574(fabF) SMc01785(fabH) SMc04273
            CCR: CC1369 CC1678 CC3719
            BSU: BG13048(fabH2) BG13127(fabH1) BG13128(fabF)
            BHA: BH0764 BH1840(fabF) BH1844(fabH) BH2882 BH2883
            SAU: SA0842(FabH) SA0843(fab)
            SAV: SAV0970 SAV0971
            LLA: L0182(fabH) L0186(fabF)
            SPY: SPy1748(fabF) SPy1754(fabH)
            SPN: SP0417 SP0422
            SPR: spr0377(fabH) spr0382(fabF)
            CAC: CAC2008(pksF) CAC3573(fabF) CAC3578(fabH)
            MTU: Rv0533c(fabH) Rv2245(kasA) Rv2246(kasB) Rv2947c(pks15)
            MTC: MT0557 MT2305 MT2306 MT3021.1
            MLE: ML1655(kasA) ML1656(kasB)
            CTR: CT239 CT770
            CMU: TC0151 TC0510
            CPN: CPn0298 CPn0916
            CPA: CP0460 CP0950
            CPJ: fabF fabH
            SYN: sll1069(fabF) slr1332(fabF) slr1511(fabH)
            DRA: DR1941 DR1946 DR1947
            AAE: aq_1099(fabH) aq_1717(fabF)
            TMA: TM0802
            TAC: Ta1455
            TVO: TVG0141026
            PHO: PH0677
            PAB: PAB0906(acaA)
            APE: APE1873
            SSO: SSO0535
            STO: ST1349
            SCE: YER061C(CEM1) YPL231W(FAS2)
            SPO: LSD1(lsd1) SPBC887.13C(spbc887.13c)
            ATH: At1g62640(T3P18.20) At1g74960(F25A4.7)
            CEL: F10G8.9
            DME: CG12170
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
STRUCTURES  PDB: 1G5X  1B3N  1DD8  1E5M  1EBL  1EK4  1F91  1FJ4  1FJ8  1HZP  
                 1HN9  1HND  1HNH  1HNJ  1HNK  1KAS  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.41
            ExPASy - ENZYME nomenclature database: 2.3.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.41
            BRENDA, the Enzyme Database: 2.3.1.41
            SCOP (Structural Classification of Proteins): 2.3.1.41
///
ENTRY       EC 2.3.1.42
NAME        Glycerone-phosphate O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:glycerone-phosphate O-acyltransferase
REACTION    Acyl-CoA + Glycerone phosphate = CoA + Acylglycerone phosphate
SUBSTRATE   Acyl-CoA
            Glycerone phosphate
            Palmitoyl-CoA
            Stearoyl-CoA
            Oleoyl-CoA
PRODUCT     CoA
            Acylglycerone phosphate
            Palmitoylglycerone phosphate
            Stearoylglycerone phosphate
            Oleoylglycerone phosphate
COMMENT     A membrane protein. Uses CoA derivatives of palmitate, stearate
            and oleate, with highest activity on palmitoyl-CoA.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.42
            ExPASy - ENZYME nomenclature database: 2.3.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.42
            BRENDA, the Enzyme Database: 2.3.1.42
///
ENTRY       EC 2.3.1.43
NAME        Phosphatidylcholine--sterol O-acyltransferase
            Lecithin--cholesterol acyltransferase
            Phospholipid--cholesterol acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Phosphatidylcholine:sterol O-acyltransferase
REACTION    Phosphatidylcholine + Sterol = 1-Acylglycerophosphocholine +
            Sterol ester
SUBSTRATE   Phosphatidylcholine
            Palmitoylphosphatidylcholine
            Oleoylphosphatidylcholine
            Linoleoylphosphatidylcholine
            Sterol
            Cholesterol
PRODUCT     1-Acylglycerophosphocholine
            1-Palmitoylglycerophosphocholine
            1-Oleoylglycerophosphocholine
            1-Linoleoylglycerophosphocholine
            Sterol ester
COMMENT     Palmitoyl, oleoyl and linoleoyl residues can be transferred; a
            number of steroids including cholesterol can act as acceptors.
            The bacterial enzyme also catalyses the reactions of EC 3.1.1.4
            and 3.1.1.5.
            (EC 3.1.1.4 Phospholipase A2)
            (EC 3.1.1.5 Lysophospholipase)
GENES       CEL: M05B5.4
            MMU: 96755(Lcat)
            HSA: 3931(LCAT)
DISEASE     MIM: 245900  Lecithin-cholesterol acyltransferase
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
            PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.43
            ExPASy - ENZYME nomenclature database: 2.3.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.43
            BRENDA, the Enzyme Database: 2.3.1.43
///
ENTRY       EC 2.3.1.44
NAME        N-Acetylneuraminate 4-O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase
REACTION    Acetyl-CoA + N-Acetylneuraminate = CoA +
            N-Acetyl-4-O-acetylneuraminate
SUBSTRATE   Acetyl-CoA
            N-Acetylneuraminate
PRODUCT     CoA
            N-Acetyl-4-O-acetylneuraminate
COMMENT     Both free and glycosidically bound N-acetyl- and N-glycolyl-
            neuraminates can act as O-acetyl acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.44
            ExPASy - ENZYME nomenclature database: 2.3.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.44
            BRENDA, the Enzyme Database: 2.3.1.44
///
ENTRY       EC 2.3.1.45
NAME        N-Acetylneuraminate 7-O(or 9-O)-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
REACTION    Acetyl-CoA + N-Acetylneuraminate = CoA +
            N-Acetyl-7-O-acetylneuraminate or N-Acetyl-9-O-acetylneuraminate
SUBSTRATE   Acetyl-CoA
            N-Acetylneuraminate
PRODUCT     CoA
            N-Acetyl-7-O-acetylneuraminate
            N-Acetyl-9-O-acetylneuraminate
COMMENT     Both free and glycosidically bound N-acetyl- and N-glycolyl-
            neuraminates can act as O-acetyl acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.45
            ExPASy - ENZYME nomenclature database: 2.3.1.45
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.45
            BRENDA, the Enzyme Database: 2.3.1.45
///
ENTRY       EC 2.3.1.46
NAME        Homoserine O-succinyltransferase
            Homoserine O-transsuccinylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:L-homoserine O-succinyltransferase
REACTION    Succinyl-CoA + L-Homoserine = CoA + O-Succinyl-L-homoserine
SUBSTRATE   Succinyl-CoA
            L-Homoserine
PRODUCT     CoA
            O-Succinyl-L-homoserine
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b4013(metA)
            ECE: Z5599(metA)
            ECS: ECs4931
            YPE: YPO3727(metA)
            VCH: VC1611
            CJE: Cj1726c(metA)
            SME: SMc03797(metA)
            BSU: BG11534(metB)
            BHA: BH2280
            LLA: L0101(metA)
            SPN: SP1576
            SPR: spr1434(metA)
            CAC: CAC1825(metB)
            TMA: TM0881
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.46
            ExPASy - ENZYME nomenclature database: 2.3.1.46
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.46
            BRENDA, the Enzyme Database: 2.3.1.46
///
ENTRY       EC 2.3.1.47
NAME        8-Amino-7-oxononanoate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     6-Carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase
            (decarboxylating)
REACTION    6-Carboxyhexanoyl-CoA + L-Alanine = 8-Amino-7-oxononanoate +
            CoA + CO2
SUBSTRATE   6-Carboxyhexanoyl-CoA
            L-Alanine
PRODUCT     8-Amino-7-oxononanoate
            CoA
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       ECO: b0776(bioF)
            ECE: Z0995(bioF)
            ECS: ECs0854
            YPE: YPO1152(bioF)
            HIN: HI1553(bioF)
            PMU: PM1901(bioF)
            XFA: XF1357
            VCH: VC1113
            PAE: PA0501(bioF)
            NME: NMB0472
            NMA: NMA2013(bioF)
            HPY: HP0598(bioF)
            HPJ: jhp0545
            CJE: Cj0306c(bioF)
            MLO: mll5830 mll6006 mll9099
            CCR: CC1576
            BSU: BG11527(bioF)
            BHA: BH3907(bioF)
            SAU: SA2212
            SAV: SAV2408
            MTU: Rv0032(bioF2) Rv1569(bioF)
            MTC: MT0037 MT1620
            MLE: ML1217(bioF)
            CPN: CPn0923 CPn1043
            CPA: CP0809 CP0943
            CPJ: bioF_1 bioF_2
            SYN: slr0917(bioF)
            AAE: aq_626(bioF)
            MJA: MJ1298(bioF)
            PHO: PH0292
            PAB: PAB1244
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
STRUCTURES  PDB: 1DJE  1BS0  1DJ9  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.47
            ExPASy - ENZYME nomenclature database: 2.3.1.47
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.47
            BRENDA, the Enzyme Database: 2.3.1.47
            SCOP (Structural Classification of Proteins): 2.3.1.47
///
ENTRY       EC 2.3.1.48
NAME        Histone acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:histone acetyltransferase
REACTION    Acetyl-CoA + Histone = CoA + Acetylhistone
SUBSTRATE   Acetyl-CoA
            Histone
PRODUCT     CoA
            Acetylhistone
COMMENT     A group of enzymes with differing specificity towards histone
            acceptors.
GENES       SCE: YPL001W(HAT1)
            DME: CG3025(mof) CG4107(Pcaf) CG5229(HAT)
            HSA: 8520(HAT1)
STRUCTURES  PDB: 1B91  1BOB  1F68  1QSM  1QSO  1YGH  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.48
            ExPASy - ENZYME nomenclature database: 2.3.1.48
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.48
            BRENDA, the Enzyme Database: 2.3.1.48
            SCOP (Structural Classification of Proteins): 2.3.1.48
///
ENTRY       EC 2.3.1.49
NAME        Deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     S-Acetylphosphopantetheine:deacetyl-[citrate-oxaloacetate-
            $lyase((pro-3S)-CH2COO-->acetate)] S-acetyltransferase
REACTION    S-Acetylphosphopantetheine +
            Deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)] =
            Phosphopantetheine +
            [Citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]
SUBSTRATE   S-Acetylphosphopantetheine
            Deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]
PRODUCT     Phosphopantetheine
            [Citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]
COMMENT     Acetylates and activates EC 4.1.3.6.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.49
            ExPASy - ENZYME nomenclature database: 2.3.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.49
            BRENDA, the Enzyme Database: 2.3.1.49
///
ENTRY       EC 2.3.1.50
NAME        Serine C-palmitoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
REACTION    Palmitoyl-CoA + L-Serine = CoA + 3-Dehydro-D-sphinganine + CO2
SUBSTRATE   Palmitoyl-CoA
            L-Serine
PRODUCT     CoA
            3-Dehydro-D-sphinganine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       SCE: YDR062W(LCB2) YMR296C(LCB1)
            SPO: LCB2(lcb2) SPBC29A3.20C
            ATH: At4g36480(AP22.60)
            CEL: C23H3.4 F43H9.2 T22G5.5
            DME: CG4016 CG4162(lace)
            HSA: 10558(SPTLC1) 9517(SPTLC2)
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.50
            ExPASy - ENZYME nomenclature database: 2.3.1.50
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.50
            BRENDA, the Enzyme Database: 2.3.1.50
///
ENTRY       EC 2.3.1.51
NAME        1-Acylglycerol-3-phosphate O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
REACTION    Acyl-CoA + 1-Acyl-sn-glycerol 3-phosphate = CoA +
            1,2-Diacyl-sn-glycerol 3-phosphate
SUBSTRATE   Acyl-CoA
            1-Acyl-sn-glycerol 3-phosphate
            Acyl-[acyl-carrier protein]
PRODUCT     CoA
            1,2-Diacyl-sn-glycerol 3-phosphate
COMMENT     Acyl-[acyl-carrier protein] can also act as acyl donor. The
            animal enzyme is specific for the transfer of unsaturated fatty
            acyl groups.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b3018(plsC)
            ECE: Z4372(plsC)
            ECS: ECs3902
            YPE: YPO0672(plsC)
            HIN: HI0734(plsC)
            PMU: PM0103(plsC)
            VCH: VC2513
            PAE: PA0005
            NME: NMB1294 NMB2034
            NMA: NMA0404(nlaB) NMA1504(plsC)
            HPY: HP1348(plsC)
            HPJ: jhp1267
            CJE: Cj0516(plsC)
            RPR: RP469(plsC)
            RCO: RC0711(plsC)
            MLO: mlr3529
            SME: SMc00714
            CCR: CC2219
            CAC: CAC0965
            MGE: MG212(plsC)
            MPN: H10_orf266(plsB)
            MPU: MYPU_1140(plsC)
            UUR: UU344(plsC)
            MTU: Rv2182c
            MTC: MT2237
            MLE: ML0892
            CTR: CT453
            CPN: CPn0569
            CPA: CP0180
            CPJ: plsC
            BBU: BB0037(plsC)
            TPA: TP0361
            TMA: TM1693
            SCE: YDL052C(SLC1)
            SPO: SPAC1851.02(spac1851.02)
            CEL: F59F4.4 T06E8.1
            DME: CG17608(fu12) CG3812
            HSA: 10554(AGPAT1) 10555(AGPAT2) 56894(AGPAT3) 56895
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.51
            ExPASy - ENZYME nomenclature database: 2.3.1.51
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.51
            BRENDA, the Enzyme Database: 2.3.1.51
///
ENTRY       EC 2.3.1.52
NAME        2-Acylglycerol-3-phosphate O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:2-acyl-sn-glycerol-3-phosphate O-acyltransferase
REACTION    Acyl-CoA + 2-Acyl-sn-glycerol 3-phosphate = CoA +
            1,2-Diacyl-sn-glycerol 3-phosphate
SUBSTRATE   Acyl-CoA
            2-Acyl-sn-glycerol 3-phosphate
PRODUCT     CoA
            1,2-Diacyl-sn-glycerol 3-phosphate
COMMENT     Saturated acyl-CoA thioesters are the most effective acyl donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.52
            ExPASy - ENZYME nomenclature database: 2.3.1.52
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.52
            BRENDA, the Enzyme Database: 2.3.1.52
///
ENTRY       EC 2.3.1.53
NAME        Phenylalanine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-phenylalanine N-acetyltransferase
REACTION    Acetyl-CoA + L-Phenylalanine = CoA + N-Acetyl-L-phenylalanine
SUBSTRATE   Acetyl-CoA
            L-Phenylalanine
PRODUCT     CoA
            N-Acetyl-L-phenylalanine
COMMENT     Also acts, more slowly, on L-histidine and L-alanine.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.53
            ExPASy - ENZYME nomenclature database: 2.3.1.53
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.53
            BRENDA, the Enzyme Database: 2.3.1.53
///
ENTRY       EC 2.3.1.54
NAME        Formate C-acetyltransferase
            Pyruvate formate-lyase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:formate C-acetyltransferase
REACTION    Acetyl-CoA + Formate = CoA + Pyruvate
SUBSTRATE   Acetyl-CoA
            Formate
PRODUCT     CoA
            Pyruvate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b0823(ybiW) b0903(pflB) b3114(tdcE) b3951(pflD)
            ECE: Z1045 Z1046 Z1248(pflB) Z4466(tdcE) Z5507(pflD)
            ECS: ECs0900 ECs0901 ECs0986 ECs3994 ECs4880
            YPE: YPO1383(pflB)
            HIN: HI0180(pflB)
            PMU: PM0075(pflB)
            VCH: VC1866
            SAU: SA0218(pflB)
            SAV: SAV0220(pflB)
            LLA: L57408(pfl)
            SPY: SPy1849(pfl) SPy2049(pflD)
            SPN: SP0251 SP0459
            SPR: spr0232(pflF) spr0415(pfl)
            CAC: CAC0980(pflB)
            MTH: MTH346
            AFU: AF1449(pflD)
MOTIF       PS: PS00850  [STIV]-x-R-[IVT]-[CSA]-G-Y-x-[GACV]
STRUCTURES  PDB: 3PFL  1CM5  1QHM  2PFL  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.54
            ExPASy - ENZYME nomenclature database: 2.3.1.54
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.54
            BRENDA, the Enzyme Database: 2.3.1.54
            SCOP (Structural Classification of Proteins): 2.3.1.54
///
ENTRY       EC 2.3.1.55
NAME        Transferred to EC 2.3.1.82
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:kanamycin N6'-acetyltransferase
COMMENT     Transferred entry. Now included in EC 2.3.1.82 - Kanamycin 6'-N-
            acetyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.55
            ExPASy - ENZYME nomenclature database: 2.3.1.55
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.55
            BRENDA, the Enzyme Database: 2.3.1.55
///
ENTRY       EC 2.3.1.56
NAME        Aromatic-hydroxylamine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     N-Hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl
            $ O-acetyltransferase
REACTION    N-Hydroxy-4-acetylaminobiphenyl + N-Hydroxy-4-aminobiphenyl =
            N-Hydroxy-4-aminobiphenyl + N-Acetoxy-4-aminobiphenyl
SUBSTRATE   N-Hydroxy-4-acetylaminobiphenyl
            N-Hydroxy-4-aminobiphenyl
PRODUCT     N-Hydroxy-4-aminobiphenyl
            N-Acetoxy-4-aminobiphenyl
COMMENT     Transfers the N-acetyl group of some aromatic acethydroxamates to
            the O-position of some aromatic hydroxylamines.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.56
            ExPASy - ENZYME nomenclature database: 2.3.1.56
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.56
            BRENDA, the Enzyme Database: 2.3.1.56
///
ENTRY       EC 2.3.1.57
NAME        Diamine N-acetyltransferase
            Spermidine acetyltransferase
            Putrescine acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase
REACTION    Acetyl-CoA + an Alkane-alpha,omega-diamine = CoA +
            an N-Acetyldiamine
SUBSTRATE   Acetyl-CoA
            Alkane-alpha,omega-diamine
            1,3-Diaminopropane
            1,5-Diaminopentane
            Putrescine
            Spermidine
            Spermine
            N1-Acetylspermidine
            N8-Acetylspermidine
PRODUCT     CoA
            N-Acetyldiamine
COMMENT     Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine,
            spermidine (forming N1- and N8-acetylspermidine), spermine,
            N1-acetylspermidine and N8-acetylspermidine
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b1584(speG)
            ECE: Z2571(speG)
            ECS: ECs2290
            YPE: YPO2830(speG)
            VCH: VCA0947
            BSU: BG10906(bltD)
            LLA: L56232(yqfF)
            SPN: SP1019
            SPR: spr0923(bltD)
            AAE: aq_1966
            MMU: 98233(Sat)
            HSA: 6303(SAT)
DISEASE     MIM: 313020  Spermidine/spermine N1-acetyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.57
            ExPASy - ENZYME nomenclature database: 2.3.1.57
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.57
            BRENDA, the Enzyme Database: 2.3.1.57
///
ENTRY       EC 2.3.1.58
NAME        2,3-Diaminopropionate N-oxalyltransferase
            Oxalyldiaminopropionate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase
REACTION    Oxalyl-CoA + L-2,3-Diaminopropanoate = CoA +
            N3-Oxalyl-L-2,3-diaminopropanoate
SUBSTRATE   Oxalyl-CoA
            L-2,3-Diaminopropanoate
PRODUCT     CoA
            N3-Oxalyl-L-2,3-diaminopropanoate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.58
            ExPASy - ENZYME nomenclature database: 2.3.1.58
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.58
            BRENDA, the Enzyme Database: 2.3.1.58
///
ENTRY       EC 2.3.1.59
NAME        Gentamicin 2'-N-acetyltransferase
            Gentamicin acetyltransferase II
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
REACTION    Acetyl-CoA + Gentamicin C1a = CoA + N2'-Acetylgentamicin C1a
SUBSTRATE   Acetyl-CoA
            Gentamicin C1a
            Gentamicin A
            Sisomicin
            Tobramycin
            Paromomycin
            Neomycin B
            Kanamycin B
            Kanamycin C
PRODUCT     CoA
            N2'-Acetylgentamicin C1a
COMMENT     The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin,
            neomycin B, kanamycin B and kanamycin C can also act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.59
            ExPASy - ENZYME nomenclature database: 2.3.1.59
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.59
            BRENDA, the Enzyme Database: 2.3.1.59
///
ENTRY       EC 2.3.1.60
NAME        Gentamicin 3'-N-acetyltransferase
            Gentamicin acetyltransferase I
            Aminoglycoside acetyltransferase AAC(3)-I
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:gentamicin-C N3'-acetyltransferase
REACTION    Acetyl-CoA + Gentamicin C = CoA + N3'-Acetylgentamicin C
SUBSTRATE   Acetyl-CoA
            Gentamicin C
            Sisomicin
PRODUCT     CoA
            N3'-Acetylgentamicin C
COMMENT     Also acetylates sisomicin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.60
            ExPASy - ENZYME nomenclature database: 2.3.1.60
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.60
            BRENDA, the Enzyme Database: 2.3.1.60
///
ENTRY       EC 2.3.1.61
NAME        Dihydrolipoamide S-succinyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:dihydrolipoamide S-succinyltransferase
REACTION    Succinyl-CoA + Dihydrolipoamide = CoA + S-Succinyldihydrolipoamide
SUBSTRATE   Succinyl-CoA
            Dihydrolipoamide
PRODUCT     CoA
            S-Succinyldihydrolipoamide
COMMENT     A lipoyl-protein; component of the multienzyme 2-oxoglutarate
            dehydrogenase complex.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00310  Lysine degradation
GENES       ECO: b0727(sucB)
            ECE: Z0881(sucB)
            ECS: ECs0752
            YPE: YPO1114(sucB)
            HIN: HI1661(sucB)
            PMU: PM0278(sucB)
            XFA: XF1549
            VCH: VC2086
            PAE: PA1586(sucB)
            BUC: BU303(sucB)
            NME: NMB0956
            NMA: NMA1150(sucB)
            RPR: RP179(sucB)
            RCO: RC0226(sucB)
            MLO: mll4300
            SME: SMc02483(sucB)
            CCR: CC0340
            BSU: BG10273(odhB)
            BHA: BH2205
            SAU: SA1244(odhB)
            MTU: Rv2215(sucB)
            MTC: MT2272
            MLE: ML0861
            CTR: CT055 CT400
            CMU: TC0325
            CPN: CPn0377 CPn0527
            CPA: CP0225 CP0379
            CPJ: sucB_1 sucB_2
            DRA: DR0083
            SCE: YDR148C(KGD2)
            SPO: SPBC776.15C(spbc776.15c)
            ATH: At4g26910(F10M23.250)
            CEL: W02F12.5
            DME: CG5214
            HSA: 1743(DLST)
DISEASE     MIM: 126063  Dihydrolipoamide S-succinyltransferase (E2 component
                         of
MOTIF       PS: PS00189  [GN]-x(2)-[LIVF]-x(5)-[LIVFC]-x(2)-[LIVFA]-x(3)-K-
                         [STAIV]-[STAVQDN]-x(2)-[LIVMFS]-x(5)-[GCN]-x-[LIVMFY]
STRUCTURES  PDB: 1BBL  1BAL  1PMR  1C4T  1E2O  1GHJ  1GHK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.61
            ExPASy - ENZYME nomenclature database: 2.3.1.61
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.61
            BRENDA, the Enzyme Database: 2.3.1.61
            SCOP (Structural Classification of Proteins): 2.3.1.61
///
ENTRY       EC 2.3.1.62
NAME        2-Acylglycerophosphocholine O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase
REACTION    Acyl-CoA + 2-Acyl-sn-glycero-3-phosphocholine = CoA +
            Phosphatidylcholine
SUBSTRATE   Acyl-CoA
            2-Acyl-sn-glycero-3-phosphocholine
PRODUCT     CoA
            Phosphatidylcholine
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.62
            ExPASy - ENZYME nomenclature database: 2.3.1.62
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.62
            BRENDA, the Enzyme Database: 2.3.1.62
///
ENTRY       EC 2.3.1.63
NAME        1-Alkylglycerophosphocholine O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
REACTION    Acyl-CoA + 1-Alkyl-sn-glycero-3-phosphocholine = CoA +
            2-Acyl-1-alkyl-sn-glycero-3-phosphocholine
SUBSTRATE   Acyl-CoA
            1-Alkyl-sn-glycero-3-phosphocholine
PRODUCT     CoA
            2-Acyl-1-alkyl-sn-glycero-3-phosphocholine
COMMENT     May be identical with EC 2.3.1.23.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.63
            ExPASy - ENZYME nomenclature database: 2.3.1.63
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.63
            BRENDA, the Enzyme Database: 2.3.1.63
///
ENTRY       EC 2.3.1.64
NAME        Agmatine N4-coumaroyltransferase
            p-Coumaroyl-CoA-agmatine N-p-coumaroyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     4-Coumaroyl-CoA:agmatine N4-coumaroyltransferase
REACTION    4-Coumaroyl-CoA + Agmatine = CoA +
            N-(4-Guanidinobutyl)-4-hydroxycinnamide
SUBSTRATE   4-Coumaroyl-CoA
            Agmatine
PRODUCT     CoA
            N-(4-Guanidinobutyl)-4-hydroxycinnamide
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.64
            ExPASy - ENZYME nomenclature database: 2.3.1.64
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.64
            BRENDA, the Enzyme Database: 2.3.1.64
///
ENTRY       EC 2.3.1.65
NAME        Glycine N-choloyltransferase
            Glycine-taurine N-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Choloyl-CoA;glycine N-choloyltransferase
REACTION    Choloyl-CoA + Glycine = CoA + Glycocholate
SUBSTRATE   Choloyl-CoA
            Glycine
PRODUCT     CoA
            Glycocholate
COMMENT     Acts on CoA derivatives of other bile acids.  Taurine can act,
            more slowly, as acceptor.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
            PATH: MAP00430  Taurine and hypotaurine metabolism
GENES       HSA: 570(BAAT)
DISEASE     MIM: 602938  Bile acid coenzyme A:amino acid N-acyltransferase
                         (glycine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.65
            ExPASy - ENZYME nomenclature database: 2.3.1.65
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.65
            BRENDA, the Enzyme Database: 2.3.1.65
///
ENTRY       EC 2.3.1.66
NAME        Leucine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-leucine N-acetyltransferase
REACTION    Acetyl-CoA + L-Leucine = CoA + N-Acetyl-L-leucine
SUBSTRATE   Acetyl-CoA
            L-Leucine
            L-Arginine
            L-Valine
            L-Phenylalanine
PRODUCT     CoA
            N-Acetyl-L-leucine
COMMENT     Propanoyl-CoA can act, more slowly, as donor; L-arginine,
            L-valine, L-phenylalanine and peptides containing L-leucine can
            act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.66
            ExPASy - ENZYME nomenclature database: 2.3.1.66
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.66
            BRENDA, the Enzyme Database: 2.3.1.66
///
ENTRY       EC 2.3.1.67
NAME        1-Alkylglycerophosphocholine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine
            $ 2-O-acetyltransferase
REACTION    Acetyl-CoA + 1-Alkyl-sn-glycero-3-phosphocholine = CoA +
            1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine
SUBSTRATE   Acetyl-CoA
            1-Alkyl-sn-glycero-3-phosphocholine
PRODUCT     CoA
            1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.67
            ExPASy - ENZYME nomenclature database: 2.3.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.67
            BRENDA, the Enzyme Database: 2.3.1.67
///
ENTRY       EC 2.3.1.68
NAME        Glutamine N-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:L-glutamine N-acyltransferase
REACTION    Acyl-CoA + L-Glutamine = CoA + N-Acyl-L-glutamine
SUBSTRATE   Acyl-CoA
            L-Glutamine
PRODUCT     CoA
            N-Acyl-L-glutamine
COMMENT     Phenylacetyl-CoA and indoleacetyl-CoA, but not benzoyl-CoA, can
            act as acyl donors.  Not identical with EC 2.3.1.13 or 2.3.1.71.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.68
            ExPASy - ENZYME nomenclature database: 2.3.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.68
            BRENDA, the Enzyme Database: 2.3.1.68
///
ENTRY       EC 2.3.1.69
NAME        Monoterpenol O-acetyltransferase
            Menthol transacetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:monoterpenol O-acetyltransferase
REACTION    Acetyl-CoA + a Monoterpenol = CoA + a Monoterpenol acetate ester
SUBSTRATE   Acetyl-CoA
            Monoterpenol
            (-)-Menthol
            (+)-Neomenthol
            Borneol
            Cyclohexanol
            n-Decanol
PRODUCT     CoA
            Monoterpenol acetate ester
COMMENT     (-)-Menthol, (+)-neomenthol, borneol, and also cyclohexanol and
            n-decanol can be acetylated.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.69
            ExPASy - ENZYME nomenclature database: 2.3.1.69
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.69
            BRENDA, the Enzyme Database: 2.3.1.69
///
ENTRY       EC 2.3.1.70
NAME        CDPacylglycerol O-arachidonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Arachidonyl-CoA:CDPacylglycerol O-arachidonyltransferase
REACTION    Arachidonyl-CoA + CDPacylglycerol = CoA + CDPdiacylglycerol
SUBSTRATE   Arachidonyl-CoA
            CDPacylglycerol
PRODUCT     CoA
            CDPdiacylglycerol
COMMENT     Highly specific for both donor and acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.70
            ExPASy - ENZYME nomenclature database: 2.3.1.70
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.70
            BRENDA, the Enzyme Database: 2.3.1.70
///
ENTRY       EC 2.3.1.71
NAME        Glycine N-benzoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Benzoyl-CoA:glycine N-benzoyltransferase
REACTION    Benzoyl-CoA + Glycine = CoA + N-Benzoylglycine
SUBSTRATE   Benzoyl-CoA
            Glycine
PRODUCT     CoA
            N-Benzoylglycine
COMMENT     Not identical with EC 2.3.1.13 or 2.3.1.68.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.71
            ExPASy - ENZYME nomenclature database: 2.3.1.71
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.71
            BRENDA, the Enzyme Database: 2.3.1.71
///
ENTRY       EC 2.3.1.72
NAME        Indoleacetylglucose--inositol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Indole-3-acetyl-beta-1-D-glucoside:myo-inositol
            indoleacetyltransferase
REACTION    Indole-3-acetyl-beta-1-D-glucoside + myo-Inositol = D-Glucose +
            Indole-3-acetyl-myo-inositol
SUBSTRATE   Indole-3-acetyl-beta-1-D-glucoside
            myo-Inositol
PRODUCT     D-Glucose
            Indole-3-acetyl-myo-inositol
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.72
            ExPASy - ENZYME nomenclature database: 2.3.1.72
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.72
            BRENDA, the Enzyme Database: 2.3.1.72
///
ENTRY       EC 2.3.1.73
NAME        Diacylglycerol--sterol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1,2-Diacyl-sn-glycerol:sterol O-acyltransferase
REACTION    1,2-Diacyl-sn-glycerol + Sterol = Monoacylglycerol + Sterol ester
SUBSTRATE   1,2-Diacyl-sn-glycerol
            Sterol
            Cholesterol
            Sitosterol
            Campesterol
            Diacylglycerol
PRODUCT     Monoacylglycerol
            Sterol ester
COMMENT     Cholesterol, sitosterol, campesterol and diacylglycerol can act as
            acceptors.  Transfered a number of logn-chain fatty acyl groups.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.73
            ExPASy - ENZYME nomenclature database: 2.3.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.73
            BRENDA, the Enzyme Database: 2.3.1.73
///
ENTRY       EC 2.3.1.74
NAME        Naringenin-chalcone synthase
            Chalcone synthase
            Flavanone synthase
            6'-Deoxychalcone synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:4-Coumaroyl-CoA malonyltransferase(cyclizing)
REACTION    3 Malonyl-CoA + 4-Coumaroyl-CoA = 4 CoA + Naringenin chalcone +
            3 CO2
SUBSTRATE   Malonyl-CoA
            4-Coumaroyl-CoA
PRODUCT     CoA
            Naringenin chalcone
            CO2
COMMENT     In the presence of NADH and a reductase, 6'-deoxychalcone is
            produced.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       BSU: BG11523(bcsA)
            BHA: BH0617(bcsA)
            MTU: Rv1660(pks10) Rv1665(pks11)
            MTC: MT1698 MT1705
            DRA: DR2091
            ATH: At4g00040(F6N15.12)
MOTIF       PS: PS00441  R-[LIVMFYS]-x-[LIVM]-x-[QHG]-x-G-C-[FYNA]-[GAPV]-G-
                         [GA]-[STAV]-x-[LIVMF]-[RAL]
STRUCTURES  PDB: 1EE0  1BI5  1BQ6  1CGK  1CGZ  1CHW  1CML  1D6F  1D6H  1D6I  
                 1QLV  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.74
            ExPASy - ENZYME nomenclature database: 2.3.1.74
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.74
            BRENDA, the Enzyme Database: 2.3.1.74
            SCOP (Structural Classification of Proteins): 2.3.1.74
///
ENTRY       EC 2.3.1.75
NAME        Long-chain-alcohol O-fatty-acyltransferase
            Wax synthase
            Wax-ester synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:long-chain-alcohol O-acyltransferase
REACTION    Acyl-CoA + a Long-chain alcohol = CoA + a Long-chain ester
SUBSTRATE   Acyl-CoA
            Long-chain alcohol
            Long-chain ester
COMMENT     Transfer saturated or unsaturated acyl residues of chain-length
            C18 to C20 to long-chain alcohols, forming waxes.  The best
            acceptor is cis-icos-11-en-1-ol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.75
            ExPASy - ENZYME nomenclature database: 2.3.1.75
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.75
            BRENDA, the Enzyme Database: 2.3.1.75
///
ENTRY       EC 2.3.1.76
NAME        Retinol O-fatty-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:retinol O-acyltransferase
REACTION    Acyl-CoA + Retinol = CoA + Retinyl ester
SUBSTRATE   Acyl-CoA
            Retinol
PRODUCT     CoA
            Retinyl ester
COMMENT     Acts on palmitoyl-CoA and other logn-chain fatty-acyl derivatives
            of CoA.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.76
            ExPASy - ENZYME nomenclature database: 2.3.1.76
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.76
            BRENDA, the Enzyme Database: 2.3.1.76
///
ENTRY       EC 2.3.1.77
NAME        Triacylglycerol--sterol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Triacylglycerol:3beta-hydroxysterol O-acyltransferase
REACTION    Triacylglycerol + a 3beta-Hydroxysterol = Diacylglycerol +
            a 3beta-Hydroxysterol ester
SUBSTRATE   Triacylglycerol
            3beta-Hydroxysterol
PRODUCT     Diacylglycerol
            3beta-Hydroxysterol ester
COMMENT     Tripalmitoylglycerol and, nore slowly, other triacylglycerols
            containing C6 to C22 faty acids, can act as donors.  The best
            acceptors are 3beta-hydroxysterols with a planar ring system.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.77
            ExPASy - ENZYME nomenclature database: 2.3.1.77
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.77
            BRENDA, the Enzyme Database: 2.3.1.77
///
ENTRY       EC 2.3.1.78
NAME        Heparan-alpha-glucosaminide N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase
REACTION    Acetyl-CoA + Heparan sulfate alpha-D-glucosaminide = CoA +
            Heparan sulfate N-acetyl-alpha-D-glucosaminide
SUBSTRATE   Acetyl-CoA
            Heparan sulfate alpha-D-glucosaminide
PRODUCT     CoA
            Heparan sulfate N-acetyl-alpha-D-glucosaminide
COMMENT     Brings about the acetylation of glucosamine groups of heparan
            sulfate and heparin from which the sulfate has been removed.  Also
            actc on heparin.  Not identical with EC 2.3.1.3 or 2.3.1.4.
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.78
            ExPASy - ENZYME nomenclature database: 2.3.1.78
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.78
            BRENDA, the Enzyme Database: 2.3.1.78
///
ENTRY       EC 2.3.1.79
NAME        Maltose O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:maltose O-acetyltransferase
REACTION    Acetyl-CoA + Maltose = CoA + Acetyl-maltose
SUBSTRATE   Acetyl-CoA
            Maltose
PRODUCT     CoA
            Acetyl-maltose
COMMENT     Not identical with EC 2.3.1.18.
GENES       ECO: b0459(maa)
            ECE: Z0571(ylaD)
            ECS: ECs0512
            MLO: mll2768
            BSU: BG10043(maa)
            BHA: BH3001
            LLA: L1734467(maa)
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.79
            ExPASy - ENZYME nomenclature database: 2.3.1.79
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.79
            BRENDA, the Enzyme Database: 2.3.1.79
///
ENTRY       EC 2.3.1.80
NAME        Cysteine-S-conjugate N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:S-substituted L-cysteine N-acetyltransferase
REACTION    Acetyl-CoA + an S-Substituted L-cysteine = CoA +
            an S-Substituted N-acetyl-L-cysteine
SUBSTRATE   Acetyl-CoA
            S-Substituted L-cysteine
PRODUCT     CoA
            S-Substituted N-acetyl-L-cysteine
COMMENT     S-Benzyl-L-cysteine and in decreasing order of activity,
            S-butyl-L-cysteine, S-propyl-L-cysteine, O-benzyl-L-cysteine and
            S-ethyl-L-cysteine, can act as acceptors.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.80
            ExPASy - ENZYME nomenclature database: 2.3.1.80
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.80
            BRENDA, the Enzyme Database: 2.3.1.80
///
ENTRY       EC 2.3.1.81
NAME        Aminoglycoside N3'-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase
REACTION    Acetyl-CoA + a 2-Deoxystreptamine antibiotic = CoA +
            N3'-Acetyl-2-deoxystreptamine antibiotic
SUBSTRATE   Acetyl-CoA
            2-Deoxystreptamine antibiotic
            Gentamicin
            Kanamycin
            Tobramycin
            Neomycin
            Apramycin
PRODUCT     CoA
            N3'-Acetyl-2-deoxystreptamine antibiotic
            N3'-Acetylgentamicin
            N3'-Acetylkanamycin
            N3'-Acetyltobramycin
            N3'-Acetylneomycin
            N3'-Acetylapramycin
COMMENT     Different from EC 2.3.1.60. A wide range of antibiotics
            containing the 2-deoxystreptamine ring can act as acceptor,
            including gentamicin, kanamycin, tobramycin, neomycin and
            apramycin.
GENES       SME: SMc02813(aacC)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.81
            ExPASy - ENZYME nomenclature database: 2.3.1.81
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.81
            BRENDA, the Enzyme Database: 2.3.1.81
///
ENTRY       EC 2.3.1.82
NAME        Kanamycin 6'-N-acetyltransferase
            Aminoglycoside N6'-acetyltransferase
            6'-Aminoglycoside-N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:kanamycin-B N6'-acetyltransferase
REACTION    Acetyl-CoA + Kanamycin = CoA + N6'-Acetylkanamycin
SUBSTRATE   Acetyl-CoA
            Kanamycin
            Kanamycin A
            Kanamycin B
            Gentamicin
            Gentamicin C1a
            Gentamicin C2
            Sisomicin
            Tobramycin
            Neomycin
PRODUCT     CoA
            N6'-Acetylkanamycin
            N6'-Acetylkanamycin-B
COMMENT     The antibiotics kanamycin A, kanamycin B, neomycin, gentamicin
            C1a, gentamicin C2, sisomicin and tobramycin are substrates.
            The antibiotics paromomycin can not act as an acceptor.
            The 6-amino group of the purpurosamine ring is acetylated.
GENES       SME: SMb21552(aacC4)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.82
            ExPASy - ENZYME nomenclature database: 2.3.1.82
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.82
            BRENDA, the Enzyme Database: 2.3.1.82
///
ENTRY       EC 2.3.1.83
NAME        Phosphatidylcholine--dolichol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     3-sn-Phosphatidylcholine:dolichol O-acyltransferase
REACTION    3-sn-Phosphatidylcholine + Dolichol = Acyldolichol +
            1-Acyl-sn-glycerol-3-phosphocholine
SUBSTRATE   3-sn-Phosphatidylcholine
            Dolichol
PRODUCT     Acyldolichol
            1-Acyl-sn-glycerol-3-phosphocholine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.83
            ExPASy - ENZYME nomenclature database: 2.3.1.83
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.83
            BRENDA, the Enzyme Database: 2.3.1.83
///
ENTRY       EC 2.3.1.84
NAME        Alcohol O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:alcohol O-acetyltransferase
REACTION    Acetyl-CoA + an Alcohol = CoA + an Acetyl ester
SUBSTRATE   Acetyl-CoA
            Alcohol
PRODUCT     CoA
            Acetyl ester
COMMENT     Acts on a range of short-chain aliphatic alcohols, including
            methanol and ethanol.
GENES       SCE: YGR177C(ATF2) YOR377W(ATF1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.84
            ExPASy - ENZYME nomenclature database: 2.3.1.84
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.84
            BRENDA, the Enzyme Database: 2.3.1.84
///
ENTRY       EC 2.3.1.85
NAME        Fatty-acid synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:malonyl-CoA C-acyltransferase(decarboxylating,
            oxoacyl- and enoyl-reducing and thioester-hydrolysing)
REACTION    Acetyl-CoA + n Malonyl-CoA + 2n NADPH = Long-chain fatty acid +
            n CO2 + 2n NADP+ + (n+1) CoA
SUBSTRATE   Acetyl-CoA
            Malonyl-CoA
            NADPH
PRODUCT     Long-chain fatty acid
            CoA
            CO2
            NADP+
COMMENT     The animal enzyme is a multi-functional protein catalysing the
            reactions of EC 2.3.1.38, 2.3.1.39, 2.3.1.41, 1.1.1.100,
            4.2.1.61, 1.3.1.10 and 3.1.2.14.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       CEL: F32H2.5
            HSA: 2194(FASN)
DISEASE     MIM: 600212  Fatty acid synthase
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.85
            ExPASy - ENZYME nomenclature database: 2.3.1.85
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.85
            BRENDA, the Enzyme Database: 2.3.1.85
///
ENTRY       EC 2.3.1.86
NAME        Fatty-acyl-CoA synthase
            Yeast fatty acid synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:malonyl-CoA C-acyltransferase(decarboxylating,
            oxoacyl- and enoyl-reducing)
REACTION    Acetyl-CoA + n Malonyl-CoA + 2 NADH + 2 NADPH =
            Long-chain acyl-CoA + n CoA + n CO2 + n NAD+ + n NADP+
SUBSTRATE   Acetyl-CoA
            Malonyl-CoA
            NADH
            NADPH
PRODUCT     Long-chain acyl-CoA
            CoA
            CO2
            NAD+
            NADP+
COMMENT     The yeast enzyme is a multifunctional protein catalysing the
            reaction of EC 2.3.1.38, 2.3.1.39, 2.4.1.41, 1.1.1.100, 4.2.1.61
            and 1.3.1.9.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       SCE: YKL182W(FAS1) YPL231W(FAS2)
            SPO: LSD1(lsd1) SPAC926.09C(spac926.09c)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.86
            ExPASy - ENZYME nomenclature database: 2.3.1.86
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.86
            BRENDA, the Enzyme Database: 2.3.1.86
///
ENTRY       EC 2.3.1.87
NAME        Aralkylamine N-acetyltransferase
            Serotonin acetyltransferase
            Serotonin acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:aralkylamine N-acetyltransferase
REACTION    Acetyl-CoA + an Aralkylamine = CoA + an N-Acetylaralkylamine
SUBSTRATE   Acetyl-CoA
            Aralkylamine
PRODUCT     CoA
            N-Acetylaralkylamine
COMMENT     Narrow specificity towards aralkylamines, including serotonin.
            Not identical with EC 2.3.1.5.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       DME: CG3318(Dat)
            HSA: 15(AANAT)
STRUCTURES  PDB: 1IB1  1B6B  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.87
            ExPASy - ENZYME nomenclature database: 2.3.1.87
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.87
            BRENDA, the Enzyme Database: 2.3.1.87
            SCOP (Structural Classification of Proteins): 2.3.1.87
///
ENTRY       EC 2.3.1.88
NAME        Peptide alpha-N-acetyltransferase
            beta-Endorphin acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:peptide Nalpha-acetyltransferase
REACTION    Acetyl-CoA + Peptide = CoA + Nalpha-Acetylpeptide
SUBSTRATE   Acetyl-CoA
            Peptide
            beta-Endorphin
            Corticotropin
            alpha-Melanotropin
PRODUCT     CoA
            Nalpha-Acetylpeptide
            N-Acetyl-beta-endorphin
            N-Acetylcorticotropin
            N-Acetyl-alpha-melanotropin
COMMENT     Acetylates N-terminal alanine, serine, methionine and glutamate
            residues in a number of peptides and proteins, including
            beta-endorphin, corticotropins and alpha-melanotropin.
            cf. EC 2.3.1.108.
GENES       MTH: MTH999
            APE: APE1954
            SCE: YDL040C(NAT1) YGR147C(NAT2)
            DME: CG12202
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.88
            ExPASy - ENZYME nomenclature database: 2.3.1.88
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.88
            BRENDA, the Enzyme Database: 2.3.1.88
///
ENTRY       EC 2.3.1.89
NAME        Tetrahydrodipicolinate N-acetyltransferase
            Tetrahydrodipicolinate acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase
REACTION    Acetyl-CoA + L-2,3,4,5-Tetrahydrodipicolinate = CoA +
            L-2-Acetamido-6-oxo-heptanedioate
SUBSTRATE   Acetyl-CoA
            L-2,3,4,5-Tetrahydrodipicolinate
PRODUCT     CoA
            L-2-Acetamido-6-oxo-heptanedioate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.89
            ExPASy - ENZYME nomenclature database: 2.3.1.89
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.89
            BRENDA, the Enzyme Database: 2.3.1.89
///
ENTRY       EC 2.3.1.90
NAME        beta-Glucogallin O-galloyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1-O-Galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose
            $ O-galloyltransferase
REACTION    2 1-O-Galloyl-beta-D-glucose = D-Glucose +
            1-O,6-O-Digalloyl-beta-D-glucose
SUBSTRATE   1-O-Galloyl-beta-D-glucose
            1-O,6-O-Digalloyl-beta-D-glucose
PRODUCT     D-Glucose
            1-O,6-O-Digalloyl-beta-D-glucose
            1-O,2-O,6-O-Trigalloyl-beta-D-glucose
COMMENT     beta-Glucogallin can act as donor and as acceptor.
            Digalloylglucose can also act as acceptor, with the formation of
            1-O,2-O,6-O-trigalloylglucose.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.90
            ExPASy - ENZYME nomenclature database: 2.3.1.90
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.90
            BRENDA, the Enzyme Database: 2.3.1.90
///
ENTRY       EC 2.3.1.91
NAME        Sinapoylglucose--choline O-sinapoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1-O-(4-Hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:
            $choline 1-O-(4-Hydroxy-3,5-dimethoxycinnamoyl)transferase
REACTION    1-O-Sinapoyl-beta-D-glucose + Choline = D-Glucose +
            Sinapoylcholine
SUBSTRATE   1-O-Sinapoyl-beta-D-glucose
            Choline
PRODUCT     D-Glucose
            Sinapoylcholine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.91
            ExPASy - ENZYME nomenclature database: 2.3.1.91
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.91
            BRENDA, the Enzyme Database: 2.3.1.91
///
ENTRY       EC 2.3.1.92
NAME        Sinapoylglucose--malate O-sinapoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1-O-Sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase
REACTION    1-O-Sinapoyl-beta-D-glucose + (S)-Malate = D-Glucose +
            Sinapoyl-(S)-malate
SUBSTRATE   1-O-Sinapoyl-beta-D-glucose
            (S)-Malate
PRODUCT     D-Glucose
            Sinapoyl-(S)-malate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.92
            ExPASy - ENZYME nomenclature database: 2.3.1.92
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.92
            BRENDA, the Enzyme Database: 2.3.1.92
///
ENTRY       EC 2.3.1.93
NAME        13-Hydroxylupinine O-tigloyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     (E)-2-Methylcrotonoyl-CoA :13-hydroxylupinine
            $O-2-methylcrotonoyltransferase
REACTION    (E)-2-Methylcrotonoyl-CoA  + 13-Hydroxylupinine = CoA +
            13-(2-Methylcrotonoyl)oxylupinine
SUBSTRATE   (E)-2-Methylcrotonoyl-CoA
            13-Hydroxylupinine
PRODUCT     CoA
            13-(2-Methylcrotonoyl)oxylupinine
COMMENT     Bezoyl-CoA and, more slowly, pentanoyl-CoA, 3-methylbutanoyl-CoA
            and butanoyl-CoA can act as acyl donors.  Involved in the
            synthesis of lupinine alkaloids.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.93
            ExPASy - ENZYME nomenclature database: 2.3.1.93
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.93
            BRENDA, the Enzyme Database: 2.3.1.93
///
ENTRY       EC 2.3.1.94
NAME        Erythronolide synthase
            Erythronolide condensing enzyme
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:propionyl-CoA malonyltransfersase (cyclizing)
REACTION    6 Malonyl-CoA + Propanoyl-CoA = 7 CoA + 6-Deoxyerythronolide b
SUBSTRATE   Malonyl-CoA
            Propanoyl-CoA
PRODUCT     CoA
            6-Deoxyerythronolide B
COMMENT     The product, which contains a 14-membered lactone ring, is an
            intermediate in the biosynthesis of erythromycin antibiotics.
            cf. EC 2.3.1.74.
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.94
            ExPASy - ENZYME nomenclature database: 2.3.1.94
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.94
            BRENDA, the Enzyme Database: 2.3.1.94
///
ENTRY       EC 2.3.1.95
NAME        Trihydroxystilbene synthase
            Resveratrol synthase
            Stilbene synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
REACTION    3 Malonyl-CoA + 4-Coumaroyl-CoA = 4 CoA +
            3,4',5-Trihydroxystilbene + 3 CO2
SUBSTRATE   Malonyl-CoA
            4-Coumaroyl-CoA
PRODUCT     CoA
            3,4',5-Trihydroxystilbene
            CO2
COMMENT     Not identical with EC 2.3.1.74 or 2.3.1.146.
            Entries S00334, S11044 and S16206 are temporally moved to this
            EC number.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
MOTIF       PS: PS00441  R-[LIVMFYS]-x-[LIVM]-x-[QHG]-x-G-C-[FYNA]-[GAPV]-G-
                         [GA]-[STAV]-x-[LIVMF]-[RAL]
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.95
            ExPASy - ENZYME nomenclature database: 2.3.1.95
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.95
            BRENDA, the Enzyme Database: 2.3.1.95
///
ENTRY       EC 2.3.1.96
NAME        Glycoprotein N-palmitoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:glycoprotein N-palmitoyltransferase
REACTION    Palmitoyl-CoA + Glycoprotein = CoA + N-Palmitoylglycoprotein
SUBSTRATE   Palmitoyl-CoA
            Glycoprotein
            Mucin
PRODUCT     CoA
            N-Palmitoylglycoprotein
EFFECTOR    1,4-Dithiothreitol
COMMENT     Acts on mucins.  Activated by 1,4-dithiothreitol.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.96
            ExPASy - ENZYME nomenclature database: 2.3.1.96
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.96
            BRENDA, the Enzyme Database: 2.3.1.96
///
ENTRY       EC 2.3.1.97
NAME        Glycylpeptide N-tetradecanoyltransferase
            Peptide N-myristoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase
REACTION    Tetradecanoyl-CoA + Glycylpeptide = CoA +
            N-Tetradecanoylglycylpeptide
SUBSTRATE   Tetradecanoyl-CoA
            Glycylpeptide
PRODUCT     CoA
            N-Tetradecanoylglycylpeptide
COMMENT     The enzyme from yeast is highly specific for tetradecanoyl-CoA,
            and highly specific for N-terminal glycine in oligopeptides
            containing serine in the 5-position. The enzyme from mammalian
            heart transfers acyl groups to a specifec accepter protein of
            51 kCa.
GENES       SCE: YLR195C(NMT1)
            SPO: SPBC2G2.11(spbc2g2.11)
            CEL: T17E9.2
            DME: CG7436(Nmt)
            HSA: 4836(NMT1) 9397(NMT2)
MOTIF       PS: PS00975  [DE]-[IV]-N-F-L-C-x-H-K
            PS: PS00976  K-F-G-x-G-D-G
STRUCTURES  PDB: 1IID  1IIC  2NMT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.97
            ExPASy - ENZYME nomenclature database: 2.3.1.97
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.97
            BRENDA, the Enzyme Database: 2.3.1.97
            SCOP (Structural Classification of Proteins): 2.3.1.97
///
ENTRY       EC 2.3.1.98
NAME        Chlorogenate--glucarate O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Chlorogenate:glucarate O-(hydroxycinnamoyl)transferase
REACTION    Chlorogenate + Glucarate = Quinate + 2-O-Caffeoylglucarate
SUBSTRATE   Chlorogenate
            Glucarate
PRODUCT     Quinate
            2-O-Caffeoylglucarate
COMMENT     Galactarate can act as acceptor, more slowly.  Involved with
            EC 2.3.1.99 in the formation of caffeoylglucarate in tomato.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.98
            ExPASy - ENZYME nomenclature database: 2.3.1.98
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.98
            BRENDA, the Enzyme Database: 2.3.1.98
///
ENTRY       EC 2.3.1.99
NAME        Quinate O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase
REACTION    Feruloyl-CoA + Quinate = CoA + O-Feruloylquinate
SUBSTRATE   Feruloyl-CoA
            Quinate
PRODUCT     CoA
            O-Feruloylquinate
COMMENT     Caffeoyl-CoA and 4-coumaroyl-CoA can also act as donors, more
            slowly.  Involved in the biosynthesis of chlorogenic acid in
            sweet potato and, with EC 2.3.1.98, in the formation of
            caffeoyl-CoA in potato.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.99
            ExPASy - ENZYME nomenclature database: 2.3.1.99
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.99
            BRENDA, the Enzyme Database: 2.3.1.99
///
ENTRY       EC 2.3.1.100
NAME        Myelin-proteolipid O-palmitoyltransferase
            Myelin PLP acyltransferase
            Acyl-protein synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:myelin-proteolipid O-palmitoyltransferase
REACTION    Palmitoyl-CoA + Myelin proteolipid = CoA +
            Myelin proteolipid O-palmitoylprotein
SUBSTRATE   Palmitoyl-CoA
            Myelin proteolipid
PRODUCT     CoA
            Myelin proteolipid O-palmitoylprotein
COMMENT     The enzyme in brain transfers long-chain acyl residues to the
            endogenous myelin proteolipid.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.100
            ExPASy - ENZYME nomenclature database: 2.3.1.100
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.100
            BRENDA, the Enzyme Database: 2.3.1.100
///
ENTRY       EC 2.3.1.101
NAME        Formylmethanofuran--tetrahydromethanopterin N-formyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Formylmethanofuran:5,6,7,8-tetrahydromethanopterin
            N5-formyltransferase
REACTION    Formylmethanofuran + 5,6,7,8-Tetrahydromethanopterin =
            Methanofuran + N5-Formyl-5,6,7,8-tetrahydromethanopterin
SUBSTRATE   Formylmethanofuran
            5,6,7,8-Tetrahydromethanopterin
PRODUCT     Methanofuran
            N5-Formyl-5,6,7,8-tetrahydromethanopterin
COMMENT     Methanofuran is a complex 4-substituted furfurylamine.
            Involved in the formation of methane from CO2 in
            Methanobacterium thermoautotrophicum.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       MJA: MJ0318(ftr)
            MTH: MTH1259(ftr) MTH403
            AFU: AF2073(ftr-1) AF2207(ftr)
STRUCTURES  PDB: 1FTR  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.101
            ExPASy - ENZYME nomenclature database: 2.3.1.101
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.101
            UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.101
            BRENDA, the Enzyme Database: 2.3.1.101
            SCOP (Structural Classification of Proteins): 2.3.1.101
///
ENTRY       EC 2.3.1.102
NAME        N6-Hydroxylysine O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase
REACTION    Acetyl-CoA + N6-Hydroxy-L-lysine = CoA +
            N6-Acetyl-N6-hydroxy-L-lysine
SUBSTRATE   Acetyl-CoA
            N6-Hydroxy-L-lysine
PRODUCT     CoA
            N6-Acetyl-N6-hydroxy-L-lysine
COMMENT     Involved in the synthesis of aerobactin from lysine in a strain of
            Escherichia coli.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.102
            ExPASy - ENZYME nomenclature database: 2.3.1.102
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.102
            BRENDA, the Enzyme Database: 2.3.1.102
///
ENTRY       EC 2.3.1.103
NAME        Sinapoylglucose--sinapoylglucose O-sinapoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1-O-(4-Hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:
            $ 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside
REACTION    2 1-O-Sinapoyl beta-D-glucoside = D-Glucose +
            1,2-Bis-O-sinapoyl-beta-D-glucoside
SUBSTRATE   1-O-Sinapoyl beta-D-glucoside
PRODUCT     D-Glucose
            1,2-Bis-O-sinapoyl-beta-D-glucoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.103
            ExPASy - ENZYME nomenclature database: 2.3.1.103
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.103
            BRENDA, the Enzyme Database: 2.3.1.103
///
ENTRY       EC 2.3.1.104
NAME        1-Alkenylglycerophosphocholine O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase
REACTION    Acyl-CoA + 1-Alkenylglycerophosphocholine = CoA +
            1-Alkenyl-2-acylglycerophosphocholine
SUBSTRATE   Acyl-CoA
            1-Alkenylglycerophosphocholine
PRODUCT     CoA
            1-Alkenyl-2-acylglycerophosphocholine
COMMENT     Not identical with EC 2.3.1.121.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.104
            ExPASy - ENZYME nomenclature database: 2.3.1.104
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.104
            BRENDA, the Enzyme Database: 2.3.1.104
///
ENTRY       EC 2.3.1.105
NAME        Alkylglycerophosphate 2-O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase
REACTION    Acetyl-CoA + 1-Alkyl-sn-glycero-3-phosphate = CoA +
            1-Alkyl-2-acetyl-sn-glycero-3-phosphate
SUBSTRATE   Acetyl-CoA
            1-Alkyl-sn-glycero-3-phosphate
PRODUCT     CoA
            1-Alkyl-2-acetyl-sn-glycero-3-phosphate
COMMENT     Involved in the biosynthesis of thrombocyte activating factor in
            animal tissues.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.105
            ExPASy - ENZYME nomenclature database: 2.3.1.105
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.105
            BRENDA, the Enzyme Database: 2.3.1.105
///
ENTRY       EC 2.3.1.106
NAME        Tartronate O-hydroxycinnamoyltransferase
            Tartronate sinapoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase
REACTION    Sinapoyl-CoA + 2-Hydroxymalonate = CoA + Sinapoyltartronate
SUBSTRATE   Sinapoyl-CoA
            2-Hydroxymalonate
            4-Coumaroyl-CoA
            Caffeoyl-CoA
            Feruloyl-CoA
PRODUCT     CoA
            Sinapoyltartronate
COMMENT     4-Coumaroyl-CoA, caffeoyl-CoA and feruloyl-CoA can also act as
            donors.  An enzyme from mung beans.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.106
            ExPASy - ENZYME nomenclature database: 2.3.1.106
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.106
            BRENDA, the Enzyme Database: 2.3.1.106
///
ENTRY       EC 2.3.1.107
NAME        17-O-Deacetylvindoline O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase
REACTION    Acetyl-CoA + 17-O-Deacetylvindoline = CoA + Vindoline
SUBSTRATE   Acetyl-CoA
            17-O-Deacetylvindoline
PRODUCT     CoA
            Vindoline
COMMENT     Catalyses the final step in the biosynthesis of vindoline from
            tabersonine in Catharanthus roseus.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.107
            ExPASy - ENZYME nomenclature database: 2.3.1.107
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.107
            BRENDA, the Enzyme Database: 2.3.1.107
///
ENTRY       EC 2.3.1.108
NAME        Tubulin N-acetyltransferase
            alpha-Tubulin acetylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:alpha-tubulin-L-lysine N(epsilon)-acetyltransferase
REACTION    Acetyl-CoA + alpha-Tubulin L-lysine = CoA +
            alpha-Tubulin N6-acetyl-L-lysine
SUBSTRATE   Acetyl-CoA
            alpha-Tubulin L-lysine
PRODUCT     CoA
            alpha-Tubulin N6-acetyl-L-lysine
COMMENT     The enzyme from Chlamydomonas flagella also acetylates mammalian
            brain alpha-tubulin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.108
            ExPASy - ENZYME nomenclature database: 2.3.1.108
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.108
            BRENDA, the Enzyme Database: 2.3.1.108
///
ENTRY       EC 2.3.1.109
NAME        Arginine N-succinyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:L-arginine N2-succinyltransferase
REACTION    Succinyl-CoA + L-Arginine = CoA + N2-Succinyl-L-arginine
SUBSTRATE   Succinyl-CoA
            L-Arginine
            L-Ornithine
PRODUCT     CoA
            N2-Succinyl-L-arginine
COMMENT     Also acts on L-ornithine.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b1747
            ECE: Z2779
            ECS: ECs2453
            YPE: YPO1963(astA)
            VCH: VC2617
            PAE: PA0896(aruF) PA0897(aruG)
            CCR: CC0581 CC1606
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.109
            ExPASy - ENZYME nomenclature database: 2.3.1.109
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.109
            BRENDA, the Enzyme Database: 2.3.1.109
///
ENTRY       EC 2.3.1.110
NAME        Tyramine N-feruloyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase
REACTION    Feruloyl-CoA + Tyramine = CoA + N-Feruloyltyramine
SUBSTRATE   Feruloyl-CoA
            Tyramine
            Cinnamoyl-CoA
            4-Coumaroyl-CoA
            Sinapoyl-CoA
PRODUCT     CoA
            N-Feruloyltyramine
COMMENT     Cinnamoyl-CoA, 4-coumaroyl-CoA and sinapoyl-CoA can also act as
            donors, and some aromatic amines can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.110
            ExPASy - ENZYME nomenclature database: 2.3.1.110
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.110
            BRENDA, the Enzyme Database: 2.3.1.110
///
ENTRY       EC 2.3.1.111
NAME        Mycocerosate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating,
            $ oxoacyl- and enoyl-reducing)
REACTION    Acyl-CoA + n Methylmalonyl-CoA + 2n NADPH =
            Multi-methyl-branched acyl-CoA + n CoA + n CO2 + 2n NADP+
SUBSTRATE   Acyl-CoA
            Methylmalonyl-CoA
            NADPH
PRODUCT     Multi-methyl-branched acyl-CoA
            CoA
            CO2
            NADP+
COMMENT     The enzyme elongates CoA esters of fatty acids from C6 to C20 by
            incorporation of methylmalonyl, but not malonyl, residues, to
            form multimethyl-branched fatty-acyl-CoA such as
            2,4,6,8-tetramethyloctanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.111
            ExPASy - ENZYME nomenclature database: 2.3.1.111
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.111
            BRENDA, the Enzyme Database: 2.3.1.111
///
ENTRY       EC 2.3.1.112
NAME        D-Tryptophan N-malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:D-tryptophan N-malonyltransferase
REACTION    Malonyl-CoA + D-Tryptophan = CoA + N2-Malonyl-D-tryptophan
SUBSTRATE   Malonyl-CoA
            D-Tryptophan
PRODUCT     CoA
            N2-Malonyl-D-tryptophan
COMMENT     1-Aminocyclopropane-1-carboxylate can act instead of malonyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.112
            ExPASy - ENZYME nomenclature database: 2.3.1.112
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.112
            BRENDA, the Enzyme Database: 2.3.1.112
///
ENTRY       EC 2.3.1.113
NAME        Anthranilate N-malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:anthranilate N-malonyltransferase
REACTION    Malonyl-CoA + Anthranilate = CoA + N-Malonylanthranilate
SUBSTRATE   Malonyl-CoA
            Anthranilate
PRODUCT     CoA
            N-Malonylanthranilate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.113
            ExPASy - ENZYME nomenclature database: 2.3.1.113
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.113
            BRENDA, the Enzyme Database: 2.3.1.113
///
ENTRY       EC 2.3.1.114
NAME        3,4-Dichloroaniline N-malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:3,4-dichloroaniline N-malonyltransferase
REACTION    Malonyl-CoA + 3,4-Dichloroaniline = CoA +
            N-(3,4-Dichlorophenyl)-malonamate
SUBSTRATE   Malonyl-CoA
            3,4-Dichloroaniline
PRODUCT     CoA
            N-(3,4-Dichlorophenyl)-malonamate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.114
            ExPASy - ENZYME nomenclature database: 2.3.1.114
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.114
            BRENDA, the Enzyme Database: 2.3.1.114
///
ENTRY       EC 2.3.1.115
NAME        Isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
            Flavone/flavonol 7-O-beta-D-glucoside malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:isoflavone-7-O-beta-D-glucoside
            $ 6''-O-malonyltransferase
REACTION    Malonyl-CoA + Biochanin A-beta-D-glucoside = CoA + 6''-O-Malonyl-
            $biochanin A-beta-D-glucoside
SUBSTRATE   Malonyl-CoA
            Biochanin A-beta-D-glucoside
PRODUCT     CoA
            6''-O-Malonyl-biochanin A-beta-D-glucoside
COMMENT     The 6-position of the glucose residue of formononetin can also act
            as acceptor; some other 7-O-glucosides of isoflavones, flavones
            and flavonols can also act, more slowly.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.115
            ExPASy - ENZYME nomenclature database: 2.3.1.115
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.115
            BRENDA, the Enzyme Database: 2.3.1.115
///
ENTRY       EC 2.3.1.116
NAME        Flavonol-3-O-beta-glucoside O-malonyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:flavonol-3-O-beta-D-glucoside malonyltransferase
REACTION    Malonyl-CoA + Flavonol 3-O-beta-D-glucoside = CoA +
            Malonyl-flavonol 3-O-beta-D-glucoside
SUBSTRATE   Malonyl-CoA
            Flavonol 3-O-beta-D-glucoside
PRODUCT     CoA
            Malonyl-flavonol 3-O-beta-D-glucoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.116
            ExPASy - ENZYME nomenclature database: 2.3.1.116
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.116
            BRENDA, the Enzyme Database: 2.3.1.116
///
ENTRY       EC 2.3.1.117
NAME        2,3,4,5-Tetrahydropyridine-2-carboxylate N-succinyltransferase
            Tetrahydropicolinate succinylase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Succinyl-CoA:2,3,4,5-tetrahydropyridine-2-carboxylate
            $ N-succinyltransferase
REACTION    Succinyl-CoA + 2,3,4,5-Tetrahydropyridine-2-carboxylate = CoA +
            N-Succinyl-L-2-amino-6-oxoheptanedioate
SUBSTRATE   Succinyl-CoA
            2,3,4,5-Tetrahydropyridine-2-carboxylate
PRODUCT     CoA
            N-Succinyl-L-2-amino-6-oxoheptanedioate
COMMENT     Involved in the biosynthesis of lysine in bacteria, blue-green
            algae and higher plants.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b0166(dapD)
            ECE: Z0176(dapD)
            ECS: ECs0168
            YPE: YPO1041(dapD)
            HIN: HI1634(dapD)
            PMU: PM0658(dapD)
            XFA: XF0114
            VCH: VC2329
            PAE: PA3666(dapD)
            BUC: BU229(dapD)
            NME: NMB0335
            NMA: NMA2153(dapD)
            HPY: HP0626(dapD)
            HPJ: jhp0570
            CJE: Cj1605c(dapD)
            RPR: RP194(dapD)
            RCO: RC0243(dapD)
            MLO: mlr4843
            SME: SMc01732(dapD)
            CCR: CC0281
            BSU: BG13301(dapD)
            BHA: BH2669
            SAU: SA1229(dapD)
            SAV: SAV1382(dapD)
            LLA: L79267(ychH)
            SPN: SP2097
            SPR: spr1907(dapD)
            CAC: CAC2381(dapD)
            MTU: Rv1201c
            MTC: MT1239
            MLE: ML1058
            TMA: TM1519
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
STRUCTURES  PDB: 3TDT  2TDT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.117
            ExPASy - ENZYME nomenclature database: 2.3.1.117
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.117
            BRENDA, the Enzyme Database: 2.3.1.117
            SCOP (Structural Classification of Proteins): 2.3.1.117
///
ENTRY       EC 2.3.1.118
NAME        N-Hydroxyarylamine O-acetyltransferase
            Arylhydroxamate N,O-acetyltransferase
            Arylamine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:N-hydroxyarylamine O-acetyltransferase
REACTION    Acetyl-CoA + an N-Hydroxyarylamine = CoA +
            an N-Acetoxyarylamine
SUBSTRATE   Acetyl-CoA
            N-Hydroxyarylamine
            Arylamine
            Arylhydroxamate
PRODUCT     CoA
            N-Acetoxyarylamine
COMMENT     The enzyme from liver, but not that from bacteria, can also
            catalyse N-acetylation of arylamines and N,O-acetylation of
            arylhydroxamates.
GENES       ECO: b1463
            ECE: Z2250
            ECS: ECs2066
            MLO: mll5814
            CCR: CC1563
STRUCTURES  PDB: 1E2T  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.118
            ExPASy - ENZYME nomenclature database: 2.3.1.118
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.118
            BRENDA, the Enzyme Database: 2.3.1.118
            SCOP (Structural Classification of Proteins): 2.3.1.118
///
ENTRY       EC 2.3.1.119
NAME        Icosanoyl-CoA synthase
            Acyl-CoA elongase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating,
            oxoacyl- and enoyl-reducing)
REACTION    Stearoyl-CoA + Malonyl-CoA + 2 NADH or 2 NADPH = Eicosanoyl-CoA +
            CO2 + 2 NAD+ or 2 NADP+
SUBSTRATE   Stearoyl-CoA
            Malonyl-CoA
            NADH
            NADPH
PRODUCT     Eicosanoyl-CoA
            CO2
            NAD+
            NADP+
COMMENT     Eicosanoyl-CoA can act in place of stearoyl-CoA.  The membrane
            enzyme brings about the elongation of these long-chain fatty-
            acyl-CoAs.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.119
            ExPASy - ENZYME nomenclature database: 2.3.1.119
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.119
            BRENDA, the Enzyme Database: 2.3.1.119
///
ENTRY       EC 2.3.1.120
NAME        Deleted entry
            6'-Deoxychalcone synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
COMMENT     Deleted entry. The reaction listed is due to EC 2.3.1.74.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.120
            ExPASy - ENZYME nomenclature database: 2.3.1.120
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.120
///
ENTRY       EC 2.3.1.121
NAME        1-Alkenylglycerophosphoethanolamine O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-alkylglycerophosphoethanolamine O-acyltransferase
REACTION    Acyl-CoA + 1-Alkylglycerophosphoethanolamine = CoA +
            1-Alkyl-2-acylglycerophosphoethanolamine
SUBSTRATE   Acyl-CoA
            1-Alkylglycerophosphoethanolamine
PRODUCT     CoA
            1-Alkyl-2-acylglycerophosphoethanolamine
COMMENT     Long-chain unsaturated acyl-CoAs are the best substrates. Not
            identical with EC2.3.1.104.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.121
            ExPASy - ENZYME nomenclature database: 2.3.1.121
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.121
            BRENDA, the Enzyme Database: 2.3.1.121
///
ENTRY       EC 2.3.1.122
NAME        Trehalose O-mycolyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     alpha,alpha'-Trehalose-6-mycolate:
            $ alpha,alpha'-trehalose-6-mycolate
REACTION    2 alpha,alpha'-Trehalose 6-mycolate = alpha,alpha-Trehalose +
            alpha,alpha'-Trehalose 6,6'-bismycolate
SUBSTRATE   alpha,alpha'-Trehalose 6-mycolate
            alpha,alpha'-Trehalose 6-palmitate
PRODUCT     alpha,alpha-Trehalose
            alpha,alpha'-Trehalose 6,6'-bismycolate
COMMENT     Calyses the exchange of mycolic acid between trehalose,
            trehalose mycolate and trehalose bismycolate.  Trehalose
            6-palmitate can also act as donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.122
            ExPASy - ENZYME nomenclature database: 2.3.1.122
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.122
            BRENDA, the Enzyme Database: 2.3.1.122
///
ENTRY       EC 2.3.1.123
NAME        Dolichol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:dolichol O-palmitoyltransferase
REACTION    Palmitoyl-CoA + Dolichol = CoA + Dolicyl palmitate
SUBSTRATE   Palmitoyl-CoA
            Dolichol
PRODUCT     CoA
            Dolicyl palmitate
COMMENT     Other acyl-CoAs can act, more slowly.  alpha-Saturated dolichols
            are acylated more rapidly than the alpha-unsaturated analogues.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.123
            ExPASy - ENZYME nomenclature database: 2.3.1.123
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.123
            BRENDA, the Enzyme Database: 2.3.1.123
///
ENTRY       EC 2.3.1.124
NAME        Deleted entry
            Diacylglycerol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
COMMENT     Deleted entry. Already listed as EC 2.3.1.20.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.124
            ExPASy - ENZYME nomenclature database: 2.3.1.124
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.124
///
ENTRY       EC 2.3.1.125
NAME        1-Alkyl-2-acetylglycerol O-acyltransferase
            1-Hexadecyl-2-acetylglycerol acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase
REACTION    Acyl-CoA + 1-O-Alkyl-2-acetyl-sn-glycerol = CoA +
            1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol
SUBSTRATE   Acyl-CoA
            1-O-Alkyl-2-acetyl-sn-glycerol
PRODUCT     CoA
            1-O-Alkyl-2-acetyl-3-acyl-sn-glycerol
COMMENT     A number of acyl-CoAs can act as acyl donor; maximum activity is
            obtained with linoleoyl-CoA.  Not identical with EC 2.3.1.20.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.125
            ExPASy - ENZYME nomenclature database: 2.3.1.125
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.125
            BRENDA, the Enzyme Database: 2.3.1.125
///
ENTRY       EC 2.3.1.126
NAME        Isocitrate O-dihydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase
REACTION    Caffeoyl-CoA + Isocitrate = CoA + 2-Caffeoylisocitrate
SUBSTRATE   Caffeoyl-CoA
            Isocitrate
PRODUCT     CoA
            2-Caffeoylisocitrate
COMMENT     Feruloyl-CoA and 4-coumaroyl-CoA can also act as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.126
            ExPASy - ENZYME nomenclature database: 2.3.1.126
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.126
            BRENDA, the Enzyme Database: 2.3.1.126
///
ENTRY       EC 2.3.1.127
NAME        Ornithine N-benzoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Bezoyl-CoA:L-ornithine N-benzoyltransferase
REACTION    2 Bezoyl-CoA + L-Ornithine = 2 CoA + N2,N5-Dibenzoyl-L-ornithine
SUBSTRATE   Bezoyl-CoA
            L-Ornithine
PRODUCT     CoA
            N2,N5-Dibenzoyl-L-ornithine
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.127
            ExPASy - ENZYME nomenclature database: 2.3.1.127
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.127
            BRENDA, the Enzyme Database: 2.3.1.127
///
ENTRY       EC 2.3.1.128
NAME        Ribosomal-protein-alanine N-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase
REACTION    Acetyl-CoA + Ribosomal-protein L-alanine = CoA +
            Ribosomal-protein N-acetyl-L-alanine
SUBSTRATE   Acetyl-CoA
            Ribosomal-protein L-alanine
PRODUCT     CoA
            Ribosomal-protein N-acetyl-L-alanine
COMMENT     A group of enzymes in Escherichia coli which acetylate the
            N-Terminal alanine residues of specific ribosomal proteins.
            cf. EC 2.3.1.88.
GENES       ECO: b1066(rimJ) b4373(rimI)
            ECE: Z1703(rimJ) Z5974(rimI)
            ECS: ECs1444 ECs5331
            YPE: YPO0429(rimI) YPO2041(rimJ)
            HIN: HI0010(rimI)
            PMU: PM0960(rimI)
            XFA: XF0441
            VCH: VC0657 VC1309
            PAE: PA1928(rimJ) PA4678(rimI)
            NME: NMB1872
            NMA: NMA0584
            RPR: RP693(rimJ)
            RCO: RC1069(rimJ)
            MLO: mll7514
            SME: SMc00075(rimJ) SMc01117(rimI)
            CCR: CC0058 CC3397
            BSU: BG12201(ydiD) BG13164(yjcK)
            BHA: BH0547 BH0585
            SAU: SA1855
            SAV: SAV2035
            LLA: L93051(ycjD)
            SPY: SPy1873
            SPN: SP0128
            SPR: spr0130(rimI)
            CAC: CAC2840
            UUR: UU311(ard1)
            MTU: Rv0995 Rv3420c(rimI)
            MTC: MT1024 MT3529
            MLE: ML0184(rimJ)
            SYN: sll0310(rimI) slr0853(rimI)
            AAE: aq_567(rimI)
            AFU: AF0739
            SSO: SSO0082
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.128
            ExPASy - ENZYME nomenclature database: 2.3.1.128
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.128
            BRENDA, the Enzyme Database: 2.3.1.128
///
ENTRY       EC 2.3.1.129
NAME        Acyl-[acyl-carrier-protein]--UDP-N-
            $acetylglucosamine O-acyltransferase
            UDP-N-acetylglucosamine acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     (R)-3-Hydroxytetradecanoly-[acyl-carrier-protein]:UDP-N-acetyl-
            glucosamine 3-O-(3-hydroxytetradecanoyl)transferase
REACTION    (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein] +
            UDP-N-acetylglucosamine = [Acyl-carrier protein] +
            UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
SUBSTRATE   (R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
            UDP-N-acetylglucosamine
PRODUCT     Acyl-carrier protein
            UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
COMMENT     Involved with EC 2.4.1.182 and 2.7.1.130 in the biosynthesis of
            the phosphorylated glycolipid, Lipid A, in the outer membrane of
            Escherichia coli.
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b0181(lpxA)
            ECE: Z0193(lpxA)
            ECS: ECs0183
            YPE: YPO1056(lpxA)
            HIN: HI1061(lpxA)
            PMU: PM1996(lpxA)
            XFA: XF1043
            VCH: VC2248
            PAE: PA3644(lpxA)
            NME: NMB0178
            NMA: NMA0090(lpxA)
            HPY: HP1375(lpxA)
            HPJ: jhp1289
            CJE: Cj0274(lpxA)
            RPR: RP007(lpxA)
            RCO: RC0008(lpxA)
            MLO: mll0633
            SME: SMc02091(lpxA)
            CCR: CC1911
            CTR: CT531
            CMU: TC0818
            CPN: CPn0650
            CPA: CP0097
            CPJ: lpxA
            SYN: sll0379(lpxA)
            AAE: aq_604(lpxA)
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
STRUCTURES  PDB: 1LXA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.129
            ExPASy - ENZYME nomenclature database: 2.3.1.129
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.129
            BRENDA, the Enzyme Database: 2.3.1.129
            SCOP (Structural Classification of Proteins): 2.3.1.129
///
ENTRY       EC 2.3.1.130
NAME        Galactarate O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase
REACTION    Feruloyl-CoA + Galactarate = CoA + O-Feruloylgalactarate
SUBSTRATE   Feruloyl-CoA
            Galactarate
PRODUCT     CoA
            O-Feruloylgalactarate
COMMENT     Sinapoyl-CoA and 4-coumaroyl-CoA can also act as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.130
            ExPASy - ENZYME nomenclature database: 2.3.1.130
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.130
            BRENDA, the Enzyme Database: 2.3.1.130
///
ENTRY       EC 2.3.1.131
NAME        Glucarate O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase
REACTION    Sinapoyl-CoA + Glucarate = CoA + O-Sinapoylglucarate
SUBSTRATE   Sinapoyl-CoA
            Glucarate
PRODUCT     CoA
            O-Sinapoylglucarate
COMMENT     4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as
            donors, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.131
            ExPASy - ENZYME nomenclature database: 2.3.1.131
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.131
            BRENDA, the Enzyme Database: 2.3.1.131
///
ENTRY       EC 2.3.1.132
NAME        Glucarolactone O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase
REACTION    Sinapoyl-CoA + Glucarolactone = CoA + O-Sinapoylglucarolactone
SUBSTRATE   Sinapoyl-CoA
            Glucarolactone
PRODUCT     CoA
            O-Sinapoylglucarolactone
COMMENT     4-Coumaroyl-CoA, feruloyl-CoA and caffeoyl-CoA can also act as
            donors,  more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.132
            ExPASy - ENZYME nomenclature database: 2.3.1.132
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.132
            BRENDA, the Enzyme Database: 2.3.1.132
///
ENTRY       EC 2.3.1.133
NAME        Shikimate O-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     4-Coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase
REACTION    4-Coumaroyl-CoA + Shikimate = CoA + 4-Coumaroylshikimate
SUBSTRATE   4-Coumaroyl-CoA
            Shikimate
PRODUCT     CoA
            4-Coumaroylshikimate
COMMENT     Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as
            donors,  more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.133
            ExPASy - ENZYME nomenclature database: 2.3.1.133
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.133
            BRENDA, the Enzyme Database: 2.3.1.133
///
ENTRY       EC 2.3.1.134
NAME        Galactolipid O-acyltransferase
            Galactolipid:galactolipid acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Mono-beta-D-galactosyldiacylglycerol:
            $ mono-beta-D-galactosylglycerol acyltransferase
REACTION    2 Mono-beta-D-galactosyldiacylglycerol =
            Acylmono-beta-D-galactosyldiacylglycerol +
            Mono-beta-D-galactosylacylglycerol
SUBSTRATE   Mono-beta-D-galactosyldiacylglycerol
PRODUCT     Acylmono-beta-D-galactosyldiacylglycerol
            Mono-beta-D-galactosylacylglycerol
COMMENT     Di-D-galactosyldiacylglycerol can also act as acceptor.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.134
            ExPASy - ENZYME nomenclature database: 2.3.1.134
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.134
            BRENDA, the Enzyme Database: 2.3.1.134
///
ENTRY       EC 2.3.1.135
NAME        Phosphatidylcholine--retinol O-acyltransferase
            Lecithin--retinol acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Phosphatidylcholine:retinol-(cellular-retinol-binding-protein)
            $ O-acyltransferase
REACTION    Phosphatidylcholine + Retinol-(cellular-retinol-binding-protein) =
            2-Acylglycerophosphocholine +
            Retinyl-ester-(cellular-retinol-binding-protein)
SUBSTRATE   Phosphatidylcholine
            Retinol-(cellular-retinol-binding-protein)
PRODUCT     2-Acylglycerophosphocholine
            Retinyl-ester-(cellular-retinol-binding-protein)
COMMENT     Specific for transfer of the sn-1-acyl residue of phosphatidyl-
            choline.
GENES       HSA: 9227(LRAT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.135
            ExPASy - ENZYME nomenclature database: 2.3.1.135
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.135
            BRENDA, the Enzyme Database: 2.3.1.135
///
ENTRY       EC 2.3.1.136
NAME        Polysialic-acid O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acetyl-CoA:polysialic-acid O-acetyltransferase
REACTION    Acetyl-CoA + an alpha-2,8-Linked polymer of sialic acid = CoA +
            Polysialic acid acetylated at O-7 or Polysialic acid acetylated
            $ at O-9
SUBSTRATE   Acetyl-CoA
            alpha-2,8-Linked polymer of sialic acid
PRODUCT     CoA
            Polysialic acid acetylated at O-7
            Polysialic acid acetylated at O-9
COMMENT     Acts only on substrates containing more than 14 sialosyl residues.
            Catalyses the modification of capsular polysaccharides in some
            strains of Escherichia coli.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.136
            ExPASy - ENZYME nomenclature database: 2.3.1.136
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.136
            BRENDA, the Enzyme Database: 2.3.1.136
///
ENTRY       EC 2.3.1.137
NAME        Carnitine O-octanoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Octanoyl-CoA:L-carnitine O-octanoyltransferase
REACTION    Octanoyl-CoA + L-Carnitine = CoA + L-Octanoylcarnitine
SUBSTRATE   Octanoyl-CoA
            L-Carnitine
PRODUCT     CoA
            L-Octanoylcarnitine
COMMENT     Acts on a range of acyl-CoAs, with optimal activity with C6 or C8
            acyl groups.  cf, EC 2.3.1.7 and 2.3.1.21.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.137
            ExPASy - ENZYME nomenclature database: 2.3.1.137
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.137
            BRENDA, the Enzyme Database: 2.3.1.137
///
ENTRY       EC 2.3.1.138
NAME        Putrescine N-hydroxycinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase
REACTION    Caffeoyl-CoA + Putrescine = CoA + N-Caffeoylputrescine
SUBSTRATE   Caffeoyl-CoA
            Putrescine
PRODUCT     CoA
            N-Caffeoylputrescine
COMMENT     Feruloyl-CoA, cinnamoyl-CoA and sinapoyl-CoA can also act as
            donors, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.138
            ExPASy - ENZYME nomenclature database: 2.3.1.138
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.138
            BRENDA, the Enzyme Database: 2.3.1.138
///
ENTRY       EC 2.3.1.139
NAME        Ecdysone O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Palmitoyl-CoA:ecdysone O-palmitoyltransferase
REACTION    Palmitoyl-CoA + Ecdysone = CoA + Ecdysone palmitate
SUBSTRATE   Palmitoyl-CoA
            Ecdysone
PRODUCT     CoA
            Ecdysone palmitate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.139
            ExPASy - ENZYME nomenclature database: 2.3.1.139
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.139
            BRENDA, the Enzyme Database: 2.3.1.139
///
ENTRY       EC 2.3.1.140
NAME        Rosmarinate synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate
            $ 2'-O-caffeoyltransferase
REACTION    Caffeoyl-CoA + 3-(3,4-Dihydroxyphenyl)lactate = CoA + Rosmarinate
SUBSTRATE   Caffeoyl-CoA
            3-(3,4-Dihydroxyphenyl)lactate
PRODUCT     CoA
            Rosmarinate
COMMENT     Involved with EC 1.1.1.237 in the biosynthesis of rosmarinic acid.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.140
            ExPASy - ENZYME nomenclature database: 2.3.1.140
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.140
            BRENDA, the Enzyme Database: 2.3.1.140
///
ENTRY       EC 2.3.1.141
NAME        Galactosylacylglycerol O-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Acyl-[acyl-carrier protein]:D-galactosylacylglycerol
            $ O-acyltransferase
REACTION    Acyl-[acyl-carrier protein] + sn-3-D-Galactosyl-sn-2-acylglycerol =
            [Acyl-carrier protein] + D-Galactosyldiacylglycerol
SUBSTRATE   Acyl-[acyl-carrier protein]
            sn-3-D-Galactosyl-sn-2-acylglycerol
PRODUCT     [Acyl-carrier protein]
            D-Galactosyldiacylglycerol
COMMENT     Transfers long-chain acyl groups to the sn-1 position of the
            glycerol residue.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.141
            ExPASy - ENZYME nomenclature database: 2.3.1.141
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.141
            BRENDA, the Enzyme Database: 2.3.1.141
///
ENTRY       EC 2.3.1.142
NAME        Glycoprotein O-fatty-acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase
REACTION    Palmitoyl-CoA + Mucus glycoprotein = CoA +
            O-Palmitoylglycoprotein
SUBSTRATE   Palmitoyl-CoA
            Mucus glycoprotein
PRODUCT     CoA
            O-Palmitoylglycoprotein
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.142
            ExPASy - ENZYME nomenclature database: 2.3.1.142
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.142
            BRENDA, the Enzyme Database: 2.3.1.142
///
ENTRY       EC 2.3.1.143
NAME        beta-Glucogallin--tetrakisgalloylglucose O-galloyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     1-O-Galloyl-beta-D-glucose:
            $1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase
REACTION    1-O-Galloyl-beta-D-glucose +
            1,2,3,6-Tetrakis-O-galloyl-beta-D-glucose = D-Glucose +
            1,2,3,4,6-Pentakis-O-galloyl-beta-D-glucose
SUBSTRATE   1-O-Galloyl-beta-D-glucose
            1,2,3,6-Tetrakis-O-galloyl-beta-D-glucose
PRODUCT     D-Glucose
            1,2,3,4,6-Pentakis-O-galloyl-beta-D-glucose
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.143
            ExPASy - ENZYME nomenclature database: 2.3.1.143
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.143
            BRENDA, the Enzyme Database: 2.3.1.143
///
ENTRY       EC 2.3.1.144
NAME        Anthranilate N-benzoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Benzoyl-CoA:anthranilate N-benzoyltransferase
REACTION    Benzoyl-CoA + Anthranilate = CoA + N-Benzoylanthranilate
SUBSTRATE   Benzoyl-CoA
            Anthranilate
PRODUCT     CoA
            N-Benzoylanthranilate
COMMENT     Cinnamoyl-CoA, 4-coumaroyl-CoA and salicyloyl-CoA can act as
            donors, more slowly.  Involved in the biosynthesis of
            phytoalexins.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.144
            ExPASy - ENZYME nomenclature database: 2.3.1.144
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.144
            BRENDA, the Enzyme Database: 2.3.1.144
///
ENTRY       EC 2.3.1.145
NAME        Piperidine N-piperoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     (E,E)-Piperoyl-CoA:piperidine N-piperoyltransferase
REACTION    (E,E)-Piperoyl-CoA + Piperidine = CoA +
            N-[(E,E)-Piperoyl]piperidine
SUBSTRATE   (E,E)-Piperoyl-CoA
            Piperidine
PRODUCT     CoA
            N-[(E,E)-Piperoyl]piperidine
COMMENT     Pyrrolidine and 3-pyrroline can also act as acceptors,
            more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.145
            ExPASy - ENZYME nomenclature database: 2.3.1.145
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.145
            BRENDA, the Enzyme Database: 2.3.1.145
///
ENTRY       EC 2.3.1.146
NAME        Pinosylvin synthase
            Stilbene synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
SYSNAME     Malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)
REACTION    3 Malonyl-CoA + Cinnamoyl-CoA = 4 CoA + Pinosylvin + 3 CO2
SUBSTRATE   Malonyl-CoA
            Cinnamoyl-CoA
PRODUCT     CoA
            Pinosylvin
            CO2
COMMENT     Not identical with EC 2.3.1.74 or 2.3.1.95.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.146
            ExPASy - ENZYME nomenclature database: 2.3.1.146
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.146
            BRENDA, the Enzyme Database: 2.3.1.146
///
ENTRY       EC 2.3.1.147
NAME        Glycerophospholipid arachidonoyltransferase (CoA-independent)
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    1-Alkyl-2-arachidonyl-sn-glycero-3-phosphocholine + 1-Alkyl-2-lyso-
            $sn-glycero-3-phosphoethanolamine = 1-Alkyl-2-arachidonyl-sn-
            $glycero-3-phosphoethanolamine + 1-Alkyl-2-lyso-sn-glycero-3-
            $phosphocholine
SUBSTRATE   1-Alkyl-2-arachidonyl-sn-glycero-3-phosphocholine
            1-Alkyl-2-lyso-sn-glycero-3-phosphoethanolamine
PRODUCT     1-Alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine
            1-Alkyl-2-lyso-sn-glycero-3-phosphocholine
COMMENT     Catalyses the transfer of Arachidonate and other polyenoic fatty
            acids from intact Choline or Ethanolamine-containing
            Glycerophospho;ipids to the sn-2 position of a lyso-
            Glycophospholipid. The sn-1 position of the donor or acceptor
            molecule can possess an O-Acyl, O-Alkyl or O-Alkyl-1-enyl moiety.
            The term 'Radyl' has sometimes been used to refer to describe all
            these possible substituting groups.
            Differs from EC 2.3.1.148 in not requiring CoA and its specificity
            for poly-unsaturated fatty acyl groups.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.147
            ExPASy - ENZYME nomenclature database: 2.3.1.147
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.147
///
ENTRY       EC 2.3.1.148
NAME        Glycerophospholipid arachidonoyltransferase (CoA-dependent)
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    1-Radyl-2-acyl-sn-glycero-3-phosphocholine + 1-Radyl-2-lyso-sn-
            $glycero-3-phosphoethanolamine = 1-Radyl-2-acyl-sn-glycero-3-
            $phosphoethanolamine + 1-Radyl-2-lyso-sn-glycero-3-phosphocholine
SUBSTRATE   1-Radyl-2-acyl-sn-glycero-3-phosphocholine
            1-Radyl-2-lyso-sn-glycero-3-phosphoethanolamine
PRODUCT     1-Radyl-2-acyl-sn-glycero-3-phosphoethanolamine
            1-Radyl-2-lyso-sn-glycero-3-phosphocholine
COMMENT     Catalyses the transfer of fatty acids from intact Choline or
            Ethanolamine-containing Glycerophospholipids to the sn-2-position
            of a lyso-Glyceophospholipid. The sn-1 position of the donor or
            acceptor molecule can possess an O-Acyl, O-Alkyl or O-Alky-1-enyl
            moiety.
            Differs from 2.3.1.147 in requiring CoA and not favouring the
            transfer of poly-unsaturated fattyacyl groups.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.148
            ExPASy - ENZYME nomenclature database: 2.3.1.148
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.148
///
ENTRY       EC 2.3.1.149
NAME        Platelet-activating factor acetyltransferase
            PAF acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-Radyl-2-acyl-sn-
            $glycero-3-phospholipid = 1-Radyl-2-acetyl-sn-glycero-3-
            $phospholipid + 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine
SUBSTRATE   1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine
            1-Radyl-2-acyl-sn-glycero-3-phospholipid
PRODUCT     1-Radyl-2-acetyl-sn-glycero-3-phospholipid
            1-Alkyl-2-lyso-sn-glycero-3-phosphocholine
COMMENT     Catalyses the transfer of the acetate group from 1-Alkyl-2-acyl-
            sn-glycero-3-phospholipid (platelet-activating factor) to the sn-2
            position of lyso-Glycerophospholipids containing Ethanolamine,
            Choline, Serine, Inositol or phosphate groups at the sn-3 position
            as well as to Sphingosine and long-chain fatty alcohols.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.149
            ExPASy - ENZYME nomenclature database: 2.3.1.149
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.149
///
ENTRY       EC 2.3.1.150
NAME        Salutaridinol 7-O-acetyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    Acetyl-CoA + Salutaridinol = CoA + 7-O-Acetylsalutaridinol
SUBSTRATE   Acetyl-CoA
            Salutaridinol
PRODUCT     CoA
            7-O-Acetylsalutaridinol
COMMENT     At higher PH values the product spontaneously closes the 4->5 oxide
            bridge by allylic elimination to form the Morphine precursor
            Thebaine
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.150
            ExPASy - ENZYME nomenclature database: 2.3.1.150
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.150
///
ENTRY       EC 2.3.1.151
NAME        Benzophenone synthase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    3 Malonyl-CoA + 3-Hydroxybenzoyl-CoA = 4 CoA +
            2,3',4,6-Tetrahydroxybenzophenone + 3 CO2;
            3 Malonyl-CoA + Benzoyl-CoA = 4 CoA +
            2,4,6-Trihydroxybenzophenone + 3 CO2;
SUBSTRATE   Malonyl-CoA
            3-Hydroxybenzoyl-CoA
            Benzoyl-CoA
PRODUCT     CoA
            2,3',4,6-Tetrahydroxybenzophenone
            CO2
            2,4,6-Trihydroxybenzophenone
COMMENT     Involved in the biosynthesis of plant xanthomes.
            Benzoyl-CoA can replace 3-hydroxybenzoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.151
            ExPASy - ENZYME nomenclature database: 2.3.1.151
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.151
///
ENTRY       EC 2.3.1.152
NAME        Alcohol O-cinnamoyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    1-O-trans-Cinnamoyl-beta-D-glucopyranose + ROH = Alkyl cinnamate +
            Glucose;
            1-O-trans-Cinnamoyl-beta-D-glucopyranose + Methanol =
            Methyl cinnamate + Glucose;
            1-O-trans-Cinnamoyl-beta-D-glucopyranose + Ethanol =
            Ethyl cinnamate + Glucose;
            1-O-trans-Cinnamoyl-beta-D-glucopyranose + Propanol =
            Propyl cinnamate + Glucose
SUBSTRATE   1-O-trans-Cinnamoyl-beta-D-glucopyranose
            ROH
            Methanol
            Ethanol
            Propanol
PRODUCT     Alkyl cinnamate
            Glucose
            Methyl cinnamate
            Ethyl cinnamate
            Propyl cinnamate
COMMENT     Acceptor alcohols (ROH) include methanol, ethanol and propanol.
            No cofactors are required as 1-O-trans-cinnamoyl-beta-D-
            glucopyranose itself is an 'energy-rich' (activated) acyl-donor,
            comparable to CoA-thioesters.
            1-O-trans-Cinnamoyl-beta-D-gentobiose can also act as the acyl
            donor, but with much less affinity.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.152
            ExPASy - ENZYME nomenclature database: 2.3.1.152
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.152
///
ENTRY       EC 2.3.1.153
NAME        Anthocyanin 5-aromatic acyltransferase
CLASS       Transferases
            Acyltransferases
            Acyltransferases
REACTION    Hydroxycinnamoyl-CoA + Anthocyanidin-3,5-diglucoside = CoA +
            Anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside
SUBSTRATE   Hydroxycinnamoyl-CoA
            Anthocyanidin-3,5-diglucoside
PRODUCT     CoA
            Anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside
COMMENT     Transfers hydroxycinnamoyl group only to the C-5 glucoside of
            anthocyanin.
            Malonyl-CoA cannot act as a donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.1.153
            ExPASy - ENZYME nomenclature database: 2.3.1.153
            WIT (What Is There) Metabolic Reconstruction: 2.3.1.153
///
ENTRY       EC 2.3.2.1
NAME        D-Glutamyltransferase
            D-Glutamyl transpeptidase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     Glutamine:D-glutamyl-peptide 5-glutamyltransferase
REACTION    L-Glutamine or D-Glutamine + D-Glutamyl-peptide = NH3 +
            5-Glutamyl-D-glutamyl-peptide
SUBSTRATE   L-Glutamine
            D-Glutamine
            D-Glutamyl-peptide
PRODUCT     NH3
            5-Glutamyl-D-glutamyl-peptide
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.1
            ExPASy - ENZYME nomenclature database: 2.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.1
            BRENDA, the Enzyme Database: 2.3.2.1
///
ENTRY       EC 2.3.2.2
NAME        gamma-Glutamyltransferase
            Glutamyl transpeptidase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase
REACTION    (5-L-Glutamyl)-peptide + an Amino acid = Peptide +
            5-L-Glutamyl amino acid
SUBSTRATE   (5-L-Glutamyl)-peptide
            Glutamine
            Amino acid
PRODUCT     Peptide
            5-L-Glutamyl amino acid
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00480  Glutathione metabolism
            PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       ECO: b3447(ggt)
            ECE: Z4813(ggt)
            ECS: ECs4293
            YPE: YPO3198(ggt)
            XFA: XF0984
            VCH: VC0194 VCA0558
            PAE: PA0164 PA0361 PA1338(ggt)
            NME: NMB1057
            NMA: NMA1255(ggt)
            HPY: HP1118(ggt)
            HPJ: jhp1046
            MLO: mll6984 mlr5711
            SME: SMb20585(ggt)
            CCR: CC0104 CC0531 CC0984
            BSU: BG11838(ggt) BG12523(ywrD)
            BHA: BH0867
            SAU: SA0202
            SAV: SAV0204
            MTU: Rv0773c(ggtA) Rv2394(ggtB)
            MTC: MT0797 MT2464
            SYN: slr1269(ggt)
            DRA: DR1524
            TAC: Ta0994
            TVO: TVG0939251
            APE: APE0137
            SSO: SSO3216
            SCE: YLR299W(ECM38)
            SPO: SPAC56E4.06C(spac56e4.06c) SPAC664.09(spac664.09)
            CEL: H14N18.4 T03D8.6 Y7A9A.1
            DME: CG1492 CG17636(EG:23E12.1) CG6461
            HSA: 2678(GGT1) 2679(GGT2) 2680(GGT3) 2687(GGTLA1)
DISEASE     MIM: 137181  Gamma-glutamyltransferase-2
            MIM: 231950  Gamma-glutamyltransferase-1
MOTIF       PS: PS00462  T-[STA]-H-x-[ST]-[LIVMA]-x(4)-G-[SN]-x-V-[STA]-x-T-x-T-
                         [LIVM]-[NE]-x(1,2)-[FY]-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.2
            ExPASy - ENZYME nomenclature database: 2.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.2
            BRENDA, the Enzyme Database: 2.3.2.2
///
ENTRY       EC 2.3.2.3
NAME        Lysyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase
REACTION    L-Lysyl-tRNA + Phosphatidylglycerol = tRNA +
            Phosphatidyl-3O-L-lysyl)glycerol
SUBSTRATE   L-Lysyl-tRNA
            Phosphatidylglycerol
PRODUCT     tRNA
            Phosphatidyl-3O-L-lysyl)glycerol
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.3
            ExPASy - ENZYME nomenclature database: 2.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.3
            BRENDA, the Enzyme Database: 2.3.2.3
///
ENTRY       EC 2.3.2.4
NAME        gamma-Glutamylcyclotransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     (5-L-Glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)
REACTION    (5-L-Glutamyl)-L-amino acid = 5-Oxoproline + L-Amino acid
SUBSTRATE   (5-L-Glutamyl)-L-amino acid
PRODUCT     5-Oxoproline
            L-Amino acid
COMMENT     The enzyme acts on derivatives of L-glutamate, L-2-aminobutanoate,
            L-alanine and glycine.
PATHWAY     PATH: MAP00480  Glutathione metabolism
GENES       MMU: 95700(Ggc)
            HSA: 2655(GCTG)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.4
            ExPASy - ENZYME nomenclature database: 2.3.2.4
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.4
            BRENDA, the Enzyme Database: 2.3.2.4
///
ENTRY       EC 2.3.2.5
NAME        Glutaminyl-peptide cyclotransferase
            Glutaminyl-tRNA cyclotransferase
            Glutaminyl cyclase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Glutaminyl-peptide gamma-gluramyltransferase (cyclizing)
REACTION    L-Glutaminyl-peptide = 5-Oxoprolyl-peptide + NH3
SUBSTRATE   L-Glutaminyl-peptide
            Glutaminyl-tRNA
PRODUCT     5-Oxoprolyl-peptide
            NH3
            5-Oxoprolyl-tRNA
COMMENT     Involved in the formation of thyrotropin-releasing hormone and
            other biologically active peptides containing N-terminal
            pyroglutamyl residues. The enzyme from papaya also acts on
            glutaminyl-tRNA.
GENES       HSA: 25797(QPCT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.5
            ExPASy - ENZYME nomenclature database: 2.3.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.5
            BRENDA, the Enzyme Database: 2.3.2.5
///
ENTRY       EC 2.3.2.6
NAME        Leucyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Leucyl-tRNA:protein leucyltransferase
REACTION    L-Leucyl-tRNA + Protein = tRNA + L-Leucyl-protein
SUBSTRATE   L-Leucyl-tRNA
            Protein
PRODUCT     tRNA
            L-Leucyl-protein
COMMENT     Also transfers phenylalanyl groups.  Requires a univalent cation.
            Peptides and proteins containing an N-terminal arginine, lysine
            or histidine residue can act as acceptors.
GENES       ECO: b0885(aat)
            ECE: Z1229(aat)
            ECS: ECs0970
            XFA: XF1446
            VCH: VC1735
            PAE: PA2617(aat)
            NME: NMB0206
            NMA: NMA0063(aat)
            CJE: Cj1109(aat)
            MLO: mll0202
            SYN: sll0869(aat)
            DRA: DR1713
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.6
            ExPASy - ENZYME nomenclature database: 2.3.2.6
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.6
            BRENDA, the Enzyme Database: 2.3.2.6
///
ENTRY       EC 2.3.2.7
NAME        Aspartyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Asparagine:hydroxylamine gamma-aspartyltransferase
REACTION    L-Asparagine + Hydroxylamine = NH3 + L-Aspartylhydroxamate
SUBSTRATE   L-Asparagine
            Hydroxylamine
PRODUCT     NH3
            L-Aspartylhydroxamate
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.7
            ExPASy - ENZYME nomenclature database: 2.3.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.7
            BRENDA, the Enzyme Database: 2.3.2.7
///
ENTRY       EC 2.3.2.8
NAME        Arginyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Arginyl-tRNA:protein arginyltransferase
REACTION    L-Arginyl-tRNA + Protein = tRNA + L-Arginyl-protein
SUBSTRATE   L-Arginyl-tRNA
            Protein
            Protein(N-Glu, Asp, Cystine)
            Peptide(N-Glu, Asp, Cystine)
PRODUCT     tRNA
            L-Arginyl-protein
COFACTOR    Mercaptoethanol
            Cation
COMMENT     Requires mercaptoethanol and a univalent cation. Peptides and
            proteins containing an N-terminal glutamate, aspartate or
            cystine residue can act as acceptors.
GENES       SCE: YGL017W(ATE1)
            SPO: SPAC3C7.07C(spac3c7.07c)
            DME: CG9204(Ate1) CG9204_1(Ate1) CG9204_2(Ate1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.8
            ExPASy - ENZYME nomenclature database: 2.3.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.8
            BRENDA, the Enzyme Database: 2.3.2.8
///
ENTRY       EC 2.3.2.9
NAME        Agaritine gamma-glutamyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     (gamma-L-Glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:
            $ (aaceptor) gamma-glutamyltransferase
REACTION    Agaritine + Acceptor = 4-Hydroxymethylphenylhydrazine +
            gamma-L-Glutamyl-acceptor
SUBSTRATE   Agaritine
            Acceptor
PRODUCT     4-Hydroxymethylphenylhydrazine
            gamma-L-Glutamyl-acceptor
COMMENT     4-Hydroxyaniline, cyclohexylamine, 1-naphthylhydrazine and similar
            compounds can act as acceptors; the enzyme also catalyses the
            hydrolysis of agaritine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.9
            ExPASy - ENZYME nomenclature database: 2.3.2.9
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.9
            BRENDA, the Enzyme Database: 2.3.2.9
///
ENTRY       EC 2.3.2.10
NAME        UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-
            $D-alanyl-D-alanine N6-alanyltransferase
REACTION    L-Alanyl-tRNA +
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-
            $D-alanine = tRNA +
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-
            $D-alanyl-D-alanine
SUBSTRATE   L-Alanyl-tRNA
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-
            $D-alanine
PRODUCT     tRNA
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-
            $D-alanyl-D-alanine
COMMENT     Also acts on L-seryl-tRNA.
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.10
            ExPASy - ENZYME nomenclature database: 2.3.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.10
            BRENDA, the Enzyme Database: 2.3.2.10
///
ENTRY       EC 2.3.2.11
NAME        Alanylphosphatidylglycerol synthase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Alanyl-tRNA:phosphatidylglycerol alanyltransferase
REACTION    L-Alanyl-tRNA + Phosphatidylglycerol = tRNA +
            3-O-L-Alanyl-1-O-phosphatidylglycerol
SUBSTRATE   L-Alanyl-tRNA
            Phosphatidylglycerol
PRODUCT     tRNA
            3-O-L-Alanyl-1-O-phosphatidylglycerol
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.11
            ExPASy - ENZYME nomenclature database: 2.3.2.11
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.11
            BRENDA, the Enzyme Database: 2.3.2.11
///
ENTRY       EC 2.3.2.12
NAME        Peptidyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     Peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase
REACTION    Peptidyl-tRNA + Aminoacyl-tRNA = tRNA +
            Peptidyl-aminoacyl-tRNA
SUBSTRATE   Peptidyl-tRNA
            Aminoacyl-tRNA
PRODUCT     tRNA
            Peptidyl-aminoacyl-tRNA
COMMENT     An enzyme in ribosomes.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.12
            ExPASy - ENZYME nomenclature database: 2.3.2.12
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.12
            BRENDA, the Enzyme Database: 2.3.2.12
///
ENTRY       EC 2.3.2.13
NAME        Protein-glutamine gamma-glutamyltransferase
            Transglutaminase
            Factor XIIIa
            Fibrinoligase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     Protein-glutamine:amine gamma-glutamyltransferase
REACTION    Protein glutamine + Alkylamine = Protein N5-alkylglutamine + NH3
SUBSTRATE   Protein glutamine
            Protein lysine
            Glutamine
            Alkylamine
PRODUCT     Protein N5-alkylglutamine
            N5-Alkylglutamine
            NH3
COFACTOR    Calcium
COMMENT     Requires Ca2+. The gamma-carboxamide groups of peptide-bound
            glutamine residues act as acyl donors, and the 6-amino-groups of
            protein- and peptide-bound lysine residues act as acceptors, to
            give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks.
            Formed by proteolytic cleavage from plasma Factor XIII.
GENES       MMU: 88379(F13b)
            HSA: 2162(F13A1) 2165(F13B) 7047(TGM4) 7051(TGM1) 7052(TGM2)
                 7053(TGM3)
DISEASE     MIM: 134570  Coagulation factor XIII, A polypeptide
            MIM: 134580  Coagulation factor XIII, B polypeptide
            MIM: 190195  Transglutaminase-1 (K polypeptide epidermal type I,
                         protein-glutamine
            MIM: 190196  Transglutaminase-2 (C polypeptide,
            MIM: 600238  Transglutaminase-3 (E polypeptide,
                         protein-glutamine-gamma-glutamyl
            MIM: 600585  Transglutaminase-4, prostate
MOTIF       PS: PS00547  [GT]-Q-[CA]-W-V-x-[SA]-[GA]-[IVT]-x(2)-T-x-[LMSC]-R-
                         [CSA]-[LV]-G
STRUCTURES  PDB: 1EVU  1F13  1FAU  1FIE  1G0D  1GGT  1GGU  1GGY  1QRK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.13
            ExPASy - ENZYME nomenclature database: 2.3.2.13
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.13
            BRENDA, the Enzyme Database: 2.3.2.13
            SCOP (Structural Classification of Proteins): 2.3.2.13
///
ENTRY       EC 2.3.2.14
NAME        D-Alanine gamma-glutamyltransferase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     L-Glutamine:D-alanine gamma-glutamyltransferase
REACTION    L-Glutamine + D-Alanine = NH3 + gamma-L-Glutamyl-D-alanine
SUBSTRATE   L-Glutamine
            D-Alanine
PRODUCT     NH3
            gamma-L-Glutamyl-D-alanine
COMMENT     D-Phenylalanine and D-2-aminobutyrate can also act as acceptors,
            more slowly.  The enzyme also catalyses some of the reactions
            of EC 2.3.2.2.
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.14
            ExPASy - ENZYME nomenclature database: 2.3.2.14
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.14
            BRENDA, the Enzyme Database: 2.3.2.14
///
ENTRY       EC 2.3.2.15
NAME        Glutathione gamma-glutamylcysteinyltransferase
            Phytochelatin synthase
CLASS       Transferases
            Acyltransferases
            Aminoacyltransferases
SYSNAME     Glutathione:poly(4-glutamyl-cysteinyl)glycine
            $ 4-glutamylcysteinyltransferase
REACTION    Glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly
SUBSTRATE   Glutathione
            [Glu(-Cys)]n-Gly
PRODUCT     Gly
            [Glu(-Cys)]n+1-Gly
DBLINKS     IUBMB Enzyme Nomenclature: 2.3.2.15
            ExPASy - ENZYME nomenclature database: 2.3.2.15
            WIT (What Is There) Metabolic Reconstruction: 2.3.2.15
            BRENDA, the Enzyme Database: 2.3.2.15
///
ENTRY       EC 2.4.1.1
NAME        Phosphorylase
            Muscle phosphorylase a and b
            Amylophosphorylase
            Polyphosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan:orthophosphate alpha-D-glucosyltransferase
REACTION    (1,4-alpha-D-Glucosyl)n + Orthophosphate =
            (1,4-alpha-D-Glucosyl)n-1 + alpha-D-Glucose 1-phosphate
SUBSTRATE   (1,4-alpha-D-Glucosyl)n
            Orthophosphate
PRODUCT     (1,4-alpha-D-Glucosyl)n-1
            alpha-D-Glucose 1-phosphate
INHIBITOR   1,5-Gluconolactone
            Glucose
            Purine
COFACTOR    Pyridoxal phosphate
EFFECTOR    AMP
            IMP
            D-Glucose 6-phosphate
COMMENT     The recommended name should be qualified in each instance by
            adding the name of the natural substrate, e.g. maltodextrin
            phosphorylase, starch phosphorylase, glycogen phosphorylase.
            1,5-Gluconolactone is a very powerful reversible inhibitor of
            glycogen phosphorylase. Transition state analogue.
            Phosphorylase a and b are an active form (GPa) and inactive form
            (GPb).  From GPb to GPa is activated by AMP and IMP.
            Ser14 is phosphorylated by cAMP-activated protein kinase.
            Pyridoxal phosphate bound to Lys680 makes no mechnistic role, but
            a strucutral role.
            AMP and IMP are activator.  Glucose-6-phosphate is allosteric
            inhibitor.
            #STRUCTURE:
            Comparison of crystal strucutres of GPa and GPb are reported by
            Sprang, S.R.; et al. 1988, Nature, 336, 215-221.
            Glycogen phosphorylase is 842 a.a. and a dimer of two identical
            subunits.  Subunit is composed of two domains; domain 1 and 2.
            Domain 1: the regulatory domain (1-148).  Organized about a mostly
            parallel, nine stranded, beta-sheet core.  Two subdomains.
            Interface subdomain (1-315).  Glycogen-binding domain (316-484).
            Domain 2: contains a classical nucleotide-binding fold which is
            flanked by teo layers of helices.
            Catalytic site is located between domains 1 and 2.
            AMP: Tyr75 stack over the purine ring of AMP.  Arg309 and 310 form
            ion-pair hydrogen bonds with the phosphate group of AMP.
            Glucose-6-phosphate: the phosphate forms ion pairs with Arg309 and
            310.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3417(malP) b3428(glgP)
            ECE: Z4772(malP) Z4790(glgP)
            ECS: ECs4273
            YPE: YPO0124(malP) YPO3938(glgP)
            HIN: HI1361(glgP)
            PMU: PM0545(glgP)
            VCH: VCA0013
            PAE: PA2144(glgP)
            MLO: mlr7586
            SME: SMc04460(glgP)
            BSU: BG10911(glgP)
            BHA: BH1084(glgP)
            LLA: L99884(glgP)
            SPY: SPy1291(glgP)
            SPN: SP2106
            SPR: spr1916(malP)
            CAC: CAC0857 CAC1664(glgP)
            MTU: Rv1328(glgP)
            MTC: MT1370
            CTR: CT248
            CMU: TC0519
            CPN: CPn0307
            CPA: CP0451
            CPJ: glgP
            SYN: sll1356(glgP) slr1367(glgP)
            DRA: DR2195
            AAE: aq_717(glgP)
            MJA: MJ1631(glgP)
            PHO: PH1512
            PAB: PAB2414(agpa)
            SSO: SSO2538(glgP_or_malP)
            STO: ST0893
            SCE: YPR160W(GPH1)
            DME: CG7254(GlyP)
            HSA: 5834(PYGB) 5836(PYGL) 5837(PYGM)
DISEASE     MIM: 138550  Phosphorylase, glycogen, brain
            MIM: 232600  Phosphorylase, glycogen, muscle
            MIM: 232700  Phosphorylase, glycogen, liver
MOTIF       PS: PS00102  E-A-[SC]-G-x-[GS]-x-M-K-x(2)-[LM]-N
STRUCTURES  PDB: 1A8I  1ABB  1AHP  1AXR  1B4D  1BX3  1C50  1C8K  1C8L  1E1Y  
                 1E4O  1EM6  1EXV  1FA9  1FC0  1FS4  1FTQ  1FTW  1FTY  1FU4  
                 1FU7  1FU8  1GFZ  1GG8  1GGN  1GPA  1GPB  1GPY  1H5U  1HLF  
                 1K06  1K08  1K0Q  1NOI  1NOJ  1NOK  1PYG  1QM5  2AMV  2ECP  
                 2GPA  2GPB  2GPN  2PRI  2PRJ  2SKC  2SKD  2SKE  3AMV  3GPB  
                 4GPB  5GPB  6GPB  7GPB  8GPB  9GPB  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.1
            ExPASy - ENZYME nomenclature database: 2.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.1
            BRENDA, the Enzyme Database: 2.4.1.1
            SCOP (Structural Classification of Proteins): 2.4.1.1
///
ENTRY       EC 2.4.1.2
NAME        Dextrin dextranase
            Dextrin 6-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan:
            $1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase
REACTION    (1,4-alpha-D-Glucosyl)n + (1,6-alpha-D-Glucosyl)m =
            (1,4-alpha-D-Glucosyl)n-1 + (1,6-alpha-D-Glucosyl)m+1
SUBSTRATE   (1,4-alpha-D-Glucosyl)n
            (1,6-alpha-D-Glucosyl)m
PRODUCT     (1,4-alpha-D-Glucosyl)n
            (1,6-alpha-D-Glucosyl)m
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.2
            ExPASy - ENZYME nomenclature database: 2.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.2
            BRENDA, the Enzyme Database: 2.4.1.2
///
ENTRY       EC 2.4.1.3
NAME        Deleted entry
            Amylomaltase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.25,
            4-alpha-Glucanotransferase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.3
            ExPASy - ENZYME nomenclature database: 2.4.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.3
///
ENTRY       EC 2.4.1.4
NAME        Amylosucrase
            Sucrose--glucan glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase
REACTION    Sucrose + (1,4-alpha-D-Glucosyl)n = D-Fructose +
            (1,4-alpha-D-Glucosyl)n+1
SUBSTRATE   Sucrose
            (1,4-alpha-D-Glucosyl)n
PRODUCT     D-Fructose
            (1,4-alpha-D-Glucosyl)n+1
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.4
            ExPASy - ENZYME nomenclature database: 2.4.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.4
            BRENDA, the Enzyme Database: 2.4.1.4
///
ENTRY       EC 2.4.1.5
NAME        Dextransucrase
            Sucrose 6-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase
REACTION    Sucrose + (1,6-alpha-D-Glucosyl)n = D-Fructose +
            (1,6-alpha-D-Glucosyl)n+1
SUBSTRATE   Sucrose
            (1,6-alpha-D-Glucosyl)n
PRODUCT     D-Fructose
            (1,6-alpha-D-Glucosyl)n+1
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SPR: spr1709(gtfA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.5
            ExPASy - ENZYME nomenclature database: 2.4.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.5
            BRENDA, the Enzyme Database: 2.4.1.5
///
ENTRY       EC 2.4.1.6
NAME        Deleted entry
            Maltose 3-glycosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.6
            ExPASy - ENZYME nomenclature database: 2.4.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.6
///
ENTRY       EC 2.4.1.7
NAME        Sucrose phosphorylase
            Sucrose glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:orthophosphate alpha-D-glucosyltransferase
REACTION    Sucrose + Orthophosphate = D-Fructose +
            alpha-D-Glucose 1-phosphate
SUBSTRATE   Sucrose
            Orthophosphate
            Arsenate
PRODUCT     D-Fructose
            alpha-D-Glucose 1-phosphate
            Ketose
            L-Arabinose
COMMENT     In the forward reaction, arsenate may replace phosphate. In the
            reverse reaction various ketoses and L-arabinose may replace
            D-fructose.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1309(ycjM)
            ECE: Z2475(ycjM)
            ECS: ECs1887
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.7
            ExPASy - ENZYME nomenclature database: 2.4.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.7
            BRENDA, the Enzyme Database: 2.4.1.7
///
ENTRY       EC 2.4.1.8
NAME        Maltose phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Maltose:orthophosphate 1-beta-D-glucosyltransferase
REACTION    Maltose + Orthophosphate = D-Glucose + beta-D-Glucose 1-phosphate
SUBSTRATE   Maltose
            Orthophosphate
PRODUCT     D-Glucose
            beta-D-Glucose 1-phosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       NME: NMB0390
            NMA: NMA2094(mapA') NMA2098(mapA)
            BSU: BG12420(yvdK)
            LLA: L128690(mapA)
            CAC: CAC2685
STRUCTURES  PDB: 1H54  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.8
            ExPASy - ENZYME nomenclature database: 2.4.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.8
            BRENDA, the Enzyme Database: 2.4.1.8
///
ENTRY       EC 2.4.1.9
NAME        Inulosucrase
            Sucrose 1-fructosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase
REACTION    Sucrose + (2,1-beta-D-Fructosyl)n = Glucose +
            (2,1-beta-D-Fructosyl)n+1
SUBSTRATE   Sucrose
            (2,1-beta-D-Fructosyl)n
PRODUCT     Glucose
            (2,1-beta-D-Fructosyl)n+1
COMMENT     Converts sucrose into inulin and D-glucose.  Some other sugars can
            act as D-fructosyl acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.9
            ExPASy - ENZYME nomenclature database: 2.4.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.9
            BRENDA, the Enzyme Database: 2.4.1.9
///
ENTRY       EC 2.4.1.10
NAME        Levansucrase
            Sucrose 6-fructosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase
REACTION    Sucrose + (2,6-beta-D-Fructosyl)n = Glucose +
            (2,6-beta-D-Fructosyl)n+1
SUBSTRATE   Sucrose
            (2,6-beta-D-Fructosyl)n
PRODUCT     Glucose
            (2,6-beta-D-Fructosyl)n+1
COMMENT     Some other sugars can act as D-fructosyl acceptors.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       BSU: BG10388(sacB)
            CAC: CAC1772(sacB1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.10
            ExPASy - ENZYME nomenclature database: 2.4.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.10
            BRENDA, the Enzyme Database: 2.4.1.10
///
ENTRY       EC 2.4.1.11
NAME        Glycogen(starch) synthase
            UDPglucose--glycogen glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:glycogen 4-alpha-D-glucosyltransferase
REACTION    UDPglucose + (1,4-alpha-D-Glucosyl)n = UDP +
            (1,4-alpha-D-Glucosyl)n+1
SUBSTRATE   UDPglucose
            (1,4-alpha-D-Glucosyl)n
            Glucosylated glycogenin
PRODUCT     UDP
            (1,4-alpha-D-Glucosyl)n+1
COMMENT     The recommended name will vary according to the source of the
            enzyme and the nature of its synthetic product (cf. phosphorylase
            EC 2.4.1.1). Glycogen synthase from animal tissues is a complex of
            a catalytic sub-unit and the protein glycogenin. The enzyme
            requires glucosylated glycogenin as a primer; this is the reaction
            product of EC 2.4.1.186. A similar enzyme utilizes ADP-glucose
            (EC 2.4.1.29).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SYN: sll1393(glgA)
            SCE: YFR015C(GSY1) YLR258W(GSY2)
            DME: CG6904
            HSA: 2997(GYS1) 2998(GYS2)
DISEASE     MIM: 138570  Glycogen synthase
            MIM: 138571  Glycogen synthase-2, liver
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.11
            ExPASy - ENZYME nomenclature database: 2.4.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.11
            BRENDA, the Enzyme Database: 2.4.1.11
///
ENTRY       EC 2.4.1.12
NAME        Cellulose synthase (UDP-forming)
            UDPglucose--beta-glucan glucosyltransferase
            UDPglucose--cellulose glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase
REACTION    UDPglucose + (1,4-beta-D-Glucosyl)n =
            UDP + (1,4-beta-D-Glucosyl)n+1
SUBSTRATE   UDPglucose
            (1,4-beta-D-Glucosyl)n
PRODUCT     UDP
            (1,4-beta-D-Glucosyl)n+1
COMMENT     Involved in the synthesis of cellulose. A similar enzyme
            utilizes GDPglucose (EC 2.4.1.29).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.12
            ExPASy - ENZYME nomenclature database: 2.4.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.12
            BRENDA, the Enzyme Database: 2.4.1.12
///
ENTRY       EC 2.4.1.13
NAME        Sucrose synthase
            UDPglucose--fructose glucosyltransferase
            Sucrose--UDP glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:D-fructose 2-alpha-D-glucosyltransferase
REACTION    UDPglucose + D-Fructose = UDP + Sucrose
SUBSTRATE   UDPglucose
            D-Fructose
PRODUCT     UDP
            Sucrose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ATH: At4g02280(T2H3.8) At5g20830(T1M15.230) At5g49190(K21P3.6)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.13
            ExPASy - ENZYME nomenclature database: 2.4.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.13
            BRENDA, the Enzyme Database: 2.4.1.13
///
ENTRY       EC 2.4.1.14
NAME        Sucrose-phosphate synthase
            UDPglucose--fructosephosphate glucosyltransferase
            Sucrosephosphate--UDP glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase
REACTION    UDPglucose + D-Fructose 6-phosphate = UDP + Sucrose 6-phosphate
SUBSTRATE   UDPglucose
            D-Fructose 6-phosphate
PRODUCT     UDP
            Sucrose 6-phosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SYN: sll0045(sps)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.14
            ExPASy - ENZYME nomenclature database: 2.4.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.14
            BRENDA, the Enzyme Database: 2.4.1.14
///
ENTRY       EC 2.4.1.15
NAME        alpha,alpha-Trehalose-phosphate synthase (UDP-forming)
            UDPglucose--glucose-phosphate glucosyltransferase
            Trehalosephosphate--UDP glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase
REACTION    UDPglucose + D-Glucose 6-phosphate = UDP +
            alpha,alpha'-Trehalose 6-phosphate
SUBSTRATE   UDPglucose
            D-Glucose 6-phosphate
PRODUCT     UDP
            alpha,alpha'-Trehalose 6-phosphate
COMMENT     See also EC 2.4.1.36.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1896(otsA)
            ECE: Z2949(otsA)
            ECS: ECs2604
            MLO: mll0691
            MTU: Rv3490(otsA)
            MTC: MT3594
            MLE: ML2254(otsA)
            MTH: MTH1757
            TAC: Ta1210
            TVO: TVG1319114
            SCE: YBR126C(TPS1) YML100W(TS11) YMR261C(TPS3)
            SPO: SPAC22F8.05(spac22f8.05) SPACUNK4.16C(spacunk4.16c)
                 TPS1(tps1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.15
            ExPASy - ENZYME nomenclature database: 2.4.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.15
            BRENDA, the Enzyme Database: 2.4.1.15
///
ENTRY       EC 2.4.1.16
NAME        Chitin synthase
            Chitin-UDP N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-
            transferase
REACTION    UDP-N-acetyl-D-glucosamine + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n =
            UDP + [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            [1,4-(N-Acetyl-beta-D-glucosaminyl)]n
PRODUCT     UDP
            [1,4-(N-Acetyl-beta-D-glucosaminyl)]n+1
            Chitin
COMMENT     Converts UDP-N-acetyl-D-glucosamine into chitin and UDP
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       SCE: YBR023C(CHS3) YBR038W(CHS2) YNL192W(CHS1)
            SPO: CHS1(chs1) CHS2(chs2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.16
            ExPASy - ENZYME nomenclature database: 2.4.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.16
            BRENDA, the Enzyme Database: 2.4.1.16
///
ENTRY       EC 2.4.1.17
NAME        Glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)
REACTION    UDPglucuronate + Acceptor = UDP + Acceptor beta-D-glucuronoside
SUBSTRATE   UDPglucuronate
            Acceptor
PRODUCT     UDP
            Acceptor beta-D-glucuronoside
COMMENT     This entry denotes a family of enzymes accepting a wide range
            of substrates, including phenols, alchols, amines and fatty acids.
            Some of the activities catalysed were priviously listed separately
            as EC 2.4.1.42, 59, 61, 76, 77, 84, 107 and 108. A temporary
            nomenclature for the various forms, whose delineation is in a
            state of flux, is suggested in 513.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00150  Androgen and estrogen metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       CEL: AC3.2 B0310.5 C18C4.3 F35H8.6 R04B5.9 T03D3.1 T04H1.7 T04H1.8
                 T07C5.1a T07C5.1b T25B9.7
            DME: CG11012 CG11289 CG13270 CG13271 CG8652(EG:EG0003.4)
            MMU: 98898(Ugt1a1) 98900(Ugt2b5)
            HSA: 10720(UGT2B11) 54658(UGT1A1) 7361(UGT1A@) 7362(UGT2B)
                 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15)
                 7367(UGT2B17)
DISEASE     MIM: 191740  UDP glycosyltransferase 1A
            MIM: 600067  UDP-glucuronyltransferase, family 2, beta-4
            MIM: 600068  UDP-glucuronyltransferase, family 2, beta-7
            MIM: 600069  UDP-glucuronyltransferase, family 2, beta-15
MOTIF       PS: PS00375  [FW]-x(2)-Q-x(2)-[LIVMYA]-[LIMV]-x(4,6)-[LVGAC]-
                         [LVFYA]-[LIVMF]-[STAGCM]-[HNQ]-[STAGC]-G-x(2)-[STAG]-
                         x(3)-[STAGL]-[LIVMFA]-x(4)-[PQR]-[LIVMT]-x(3)-[PA]-
                         x(3)-[DES]-[QEHN]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.17
            ExPASy - ENZYME nomenclature database: 2.4.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.17
            BRENDA, the Enzyme Database: 2.4.1.17
///
ENTRY       EC 2.4.1.18
NAME        1,4-alpha-Glucan branching enzyme
            Branching enzyme
            Amylo-(1,4-1,6)-transglycosylase
            Q-enzyme
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan:1,4-alpha-D-glucan
            6-alpha-D-(1,4-alpha-D-glucano)-transferase
REACTION    Transfers a segment of a 1,4-alpha-D-glucan chain to a primary
            hydroxyl group in a similar glucan chain
SUBSTRATE   1,4-alpha-D-Glucan
            Amylose
            Amylopectin
            Glycogen
PRODUCT     6-alpha-D-(1,4-alpha-D-Glucano)-glucan
            Amylopectin
COMMENT     Converts amylose into amylopectin. The recommended name requires a
            qualification depending on the product, glycogen or amylopectin,
            e.g. glycogen branching enzyme, amylopectin branching enzyme.
            The latter has frequently been termed Q-enzyme.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3432(glgB)
            ECE: Z4796(glgB)
            ECS: ECs4277
            YPE: YPO3942(glgB)
            HIN: HI1357(glgB)
            PMU: PM0541(glgB)
            VCH: VCA0016
            PAE: PA2153(glgB)
            MLO: mlr7587
            SME: SMb21447(glgB2) SMc03922(glgB1)
            ATU: AGR_L_1558
            BSU: BG10907(glgB)
            SPN: SP1121
            SPR: spr1029(glgB)
            MTU: Rv1326c(glgB)
            MTC: MT1368
            CTR: CT866
            CMU: TC0257
            CPN: CPn0475
            CPA: CP0279
            CPJ: glgB
            SYN: sll0158(glgB)
            DRA: DR1848
            AAE: aq_722(glgB)
            SCE: YEL011W(GLC3)
            CEL: T04A8.7
            DME: CG4023
            HSA: 2632(GBE1)
DISEASE     MIM: 232500  Glycogen branching enzyme
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.18
            ExPASy - ENZYME nomenclature database: 2.4.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.18
            BRENDA, the Enzyme Database: 2.4.1.18
///
ENTRY       EC 2.4.1.19
NAME        Cyclomaltodextrin glucanotransferase
            Bacillus macerans amylase
            Cyclodextrin glucanotransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase
            (cyclizing)
REACTION    Cyclizes part of a 1,4-alpha-D-glucan chain by formation of a
            1,4-alpha-D-glucosidic bond
SUBSTRATE   Maltodextrin
            Starch
PRODUCT     Cyclomaltodextrin
COMMENT     Cyclomaltodextrins (Schardinger dextrins) of various sizes (6, 7,
            8, etc. glucose units) are formed reversibly from starch and
            similar substrates. Will also disproportionate linear
            maltodextrins without cyclizing (cf. EC 2.4.1.25
            4-alpha-glucanotransferase).
GENES       SPY: SPy1302(amyA)
STRUCTURES  PDB: 1CXE  9CGT  2CXG  2DIJ  1DTU  1A47  1CDG  1CGT  1CGU  1CGV  
                 1CGW  1CGX  1CGY  1CIU  1EO5  1CXF  1CXH  1CXI  1CXK  1CXL  
                 1CYG  1D3C  1D7F  1DED  8CGT  7CGT  1EO7  1I75  1PAM  1TCM  
                 6CGT  3CGT  4CGT  5CGT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.19
            ExPASy - ENZYME nomenclature database: 2.4.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.19
            BRENDA, the Enzyme Database: 2.4.1.19
            SCOP (Structural Classification of Proteins): 2.4.1.19
///
ENTRY       EC 2.4.1.20
NAME        Cellobiose phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Cellobiose:orthophosphate alpha-D-glucosyltransferase
REACTION    Cellobiose + Orthophosphate = alpha-D-Glucose 1-phosphate +
            D-Glucose
SUBSTRATE   Cellobiose
            Orthophosphate
PRODUCT     alpha-D-Glucose 1-phosphate
            D-Glucose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.20
            ExPASy - ENZYME nomenclature database: 2.4.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.20
            BRENDA, the Enzyme Database: 2.4.1.20
///
ENTRY       EC 2.4.1.21
NAME        Starch synthase
            ADPglucose--starch glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase
REACTION    ADPglucose + (1,4-alpha-D-Glucosyl)n = ADP +
            (1,4-alpha-D-Glucosyl)n+1
SUBSTRATE   ADPglucose
            (1,4-alpha-D-Glucosyl)n
PRODUCT     ADP
            (1,4-alpha-D-Glucosyl)n
COMMENT     The recommended name varies according to the source of the enzyme
            and the nature of its synthetic product, e.g. starch synthase,
            bacterial glycogen synthase. Similar to EC 2.4.1.11 but the
            preferred or mandatory nucleoside diphosphate suger substrate is
            ADPglucose. The entry covers starch and glycogen synthases
            utilizing ADPglucose.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3429(glgA)
            ECE: Z4791(glgA)
            ECS: ECs4274
            YPE: YPO3939(glgA)
            HIN: HI1360(glgA)
            PMU: PM0544(glgA)
            VCH: VC1726
            PAE: PA2165
            MLO: mlr7589
            SME: SMb20704(glgA2) SMc03924(glgA1)
            ATU: AGR_L_1562
            BSU: BG10910(glgA)
            BHA: BH1085(glgA)
            LLA: L98347(glgA)
            SPN: SP1124
            SPR: spr1032(glgA)
            CAC: CAC2239(glgA)
            CTR: CT798
            CMU: TC0181
            CPN: CPn0948
            CPA: CP0911
            CPJ: glgA
            SYN: sll0945(glgA)
            DRA: DR0594
            AAE: aq_721(glgA)
            TMA: TM0895
            MJA: MJ1606(glgA)
            PHO: PH0069
            PAB: PAB2292
            SSO: SSO0987
            STO: ST0818
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.21
            ExPASy - ENZYME nomenclature database: 2.4.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.21
            BRENDA, the Enzyme Database: 2.4.1.21
///
ENTRY       EC 2.4.1.22
NAME        Lactose synthase
            UDPgalactose--glucose galactosyltransferase
            N-Acetyllactosamine synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:D-glucose 4-beta-D-galactosyltransferase
REACTION    UDPgalactose + D-Glucose = UDP + Lactose
SUBSTRATE   UDPgalactose
            D-Glucose
            N-Acetyl-D-glucosamine
PRODUCT     UDP
            Lactose
            N-Acetyllactosamine
COMMENT     The enzyme is a complex of two proteins A and B. In the absence
            of the B protein (alpha-lactalbumin) the enzyme catalyses the
            transfer of galactose from UDP-galactose to N-acetylglucosamine
            (EC 2.4.1.90).
            (EC 2.4.1.90 N-Acetyllactosamine synthase)
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       HSA: 3906(LALBA)
DISEASE     MIM: 149750  Lactalbumin, alpha
STRUCTURES  PDB: 1HMK  1HML  1A4V  1FKQ  1FKV  1HFX  1HFY  1HFZ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.22
            ExPASy - ENZYME nomenclature database: 2.4.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.22
            BRENDA, the Enzyme Database: 2.4.1.22
            SCOP (Structural Classification of Proteins): 2.4.1.22
///
ENTRY       EC 2.4.1.23
NAME        Sphingosine beta-galactosyltransferase
            Psychosine-UDP galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:sphingosine 1-beta-galactosyltransferase
REACTION    UDPgalactose + Sphingosine = UDP + Psychosine
SUBSTRATE   UDPgalactose
            Sphingosine
PRODUCT     UDP
            Psychosine
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.23
            ExPASy - ENZYME nomenclature database: 2.4.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.23
            BRENDA, the Enzyme Database: 2.4.1.23
///
ENTRY       EC 2.4.1.24
NAME        1,4-alpha-Glucan 6-alpha-glucosyltransferase
            Oligoglucan-branching glycosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan:1,4-alpha-D-glucan(D-glucose)
            $6-alpha-D-glucosyltransferase
REACTION    Transfers an alpha-D-glucosyl residue in a 1,4-alpha-D-glucan
            to the primary hydroxy group of glucose, free or combined in a
            1,4-alpha-D-glucan
SUBSTRATE   (1,4-alpha-D-Glucosyl)n
            D-Glucose
PRODUCT     (1,4-alpha-D-Glucosyl)n
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.24
            ExPASy - ENZYME nomenclature database: 2.4.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.24
            BRENDA, the Enzyme Database: 2.4.1.24
///
ENTRY       EC 2.4.1.25
NAME        4-alpha-Glucanotransferase
            Disproportionating enzyme
            Dextrin glycosyltransferase
            D-enzyme
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-Glucan:1,4-alpha-D-glucan 4-alpha-D-
            glycosyltransferase
REACTION    Transfers a segment of a 1,4-alpha-D-glucan to a new position
            in an acceptor, which may be glucose or a 1,4-alpha-D-glucan
SUBSTRATE   1,4-alpha-D-Glucan
            D-Glucose
PRODUCT     1,4-alpha-D-Glucan
COMMENT     This entry covers the former separate entry for EC 2.4.1.3
            (amylomaltase). The plant enzyme has been termed D-enzyme.
            An enzymic activity of this nature forms part of the mammalian
            and yeast glycogen debranching system (see EC 3.2.1.33).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3416(malQ)
            ECE: Z4771(malQ)
            ECS: ECs4258
            YPE: YPO0126(malQ)
            HIN: HI1356(malQ)
            PMU: PM0540(malQ)
            VCH: VCA0014
            PAE: PA2163
            SPY: SPy1292(malM)
            SPN: SP2107
            SPR: spr1917(malM)
            MTU: Rv1781c
            MTC: MT1831
            CTR: CT087
            CMU: TC0362
            CPN: CPn0326
            CPA: CP0431
            CPJ: malQ
            BBU: BB0166(malQ)
            SYN: sll1676(malQ)
            AAE: aq_723(malM)
            TMA: TM0364
            CEL: R06A4.8
            DME: CG9485
            HSA: 178(AGL)
STRUCTURES  PDB: 1CWY  1ESW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.25
            ExPASy - ENZYME nomenclature database: 2.4.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.25
            BRENDA, the Enzyme Database: 2.4.1.25
            SCOP (Structural Classification of Proteins): 2.4.1.25
///
ENTRY       EC 2.4.1.26
NAME        DNA alpha-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:DNA alpha-D-glucosyltransferase
REACTION    Transfers an alpha-D-glucosyl residue from UDPglucose to a
            hydroxymethylcytosine residue in DNA
SUBSTRATE   UDPglucose
            DNA
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.26
            ExPASy - ENZYME nomenclature database: 2.4.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.26
            BRENDA, the Enzyme Database: 2.4.1.26
///
ENTRY       EC 2.4.1.27
NAME        DNA beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:DNA beta-D-glucosyltransferase
REACTION    Transfers an beta-D-glucosyl residue from UDPglucose to a
            hydroxymethylcytosine residue in DNA
SUBSTRATE   UDPglucose
            DNA
STRUCTURES  PDB: 2BGU  2BGT  1JG6  1BGT  1BGU  1C3J  1JEJ  1JG7  1JIU  1JIV  
                 1JIX  1QKJ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.27
            ExPASy - ENZYME nomenclature database: 2.4.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.27
            BRENDA, the Enzyme Database: 2.4.1.27
            SCOP (Structural Classification of Proteins): 2.4.1.27
///
ENTRY       EC 2.4.1.28
NAME        Glucosyl-DNA beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase
REACTION    Transfers a beta-D-glucosyl residue from UDPglucose to a
            glucosylhydroxymethylcytosine residue in DNA
SUBSTRATE   UDPglucose
            DNA
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.28
            ExPASy - ENZYME nomenclature database: 2.4.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.28
            BRENDA, the Enzyme Database: 2.4.1.28
///
ENTRY       EC 2.4.1.29
NAME        Cellulose synthase (GDP-forming)
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase
REACTION    GDPglucose + (1,4-beta-D-Glucosyl)n = GDP +
            (1,4-beta-D-Glucosyl)n+1
SUBSTRATE   GDPglucose
            (1,4-beta-D-Glucosyl)n
PRODUCT     GDP
            (1,4-beta-D-Glucosyl)n+1
COMMENT     Involved in the synthesis of cellulose.  A similar enzyme
            (EC 2.4.1.12) utilizes UDPglucose.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.29
            ExPASy - ENZYME nomenclature database: 2.4.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.29
            BRENDA, the Enzyme Database: 2.4.1.29
///
ENTRY       EC 2.4.1.30
NAME        1,3-beta-Oligoglucan phosphorylase
            beta-1,3-Oligoglucan:orthophosphate glucosyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,3-beta-D-Oligoglucan:orthophosphate alpha-D-glucosyltransferase
REACTION    (1,3-beta-D-Glucosyl)n + Orthophosphate =
            (1,3-beta-D-Glucosyl)n-1 + alpha-D-Glucose 1-phosphate
SUBSTRATE   (1,3-beta-D-Glucosyl)n
            Orthophosphate
PRODUCT     (1,3-beta-D-Glucosyl)n-1
            alpha-D-Glucose 1-phosphate
COMMENT     Does not act on laminarin.  Differs in specificity from
            EC 2.4.1.31 and 2.4.1.97.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.30
            ExPASy - ENZYME nomenclature database: 2.4.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.30
            BRENDA, the Enzyme Database: 2.4.1.30
///
ENTRY       EC 2.4.1.31
NAME        Laminaribiose phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     3-beta-D-Glucosylglucose:
            orthophosphate alpha-D-glucosyltransferase
REACTION    3-beta-D-Glucosyl-D-glucose + Orthophosphate = D-Glucose +
            alpha-D-Glucose 1-phosphate
SUBSTRATE   3-beta-D-Glucosyl-D-glucose
            1,3-beta-D-Oligoglucan
            Orthophosphate
PRODUCT     D-Glucose
            alpha-D-Glucose 1-phosphate
COMMENT     Also acts on 1,3-beta-D-oligoglucans. Differs in specificity from
            EC 2.4.1.30 and 2.4.1.97.
            (EC 2.4.1.30 1,3-beta-Oligoglucan phosphorylase)
            (EC 2.4.1.97 1,3-beta-Glucan phosphorylase)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.31
            ExPASy - ENZYME nomenclature database: 2.4.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.31
            BRENDA, the Enzyme Database: 2.4.1.31
///
ENTRY       EC 2.4.1.32
NAME        Glucomannan 4-beta-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:glucomannan 1,4-beta-D-mannosyltransferase
REACTION    GDPmannose + (Glucomannan)n = GDP + (Glucomannan)n+1
SUBSTRATE   GDPmannose
            (Glucomannan)n
PRODUCT     GDP
            (Glucomannan)n+1
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.32
            ExPASy - ENZYME nomenclature database: 2.4.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.32
            BRENDA, the Enzyme Database: 2.4.1.32
///
ENTRY       EC 2.4.1.33
NAME        Alginate synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-D-mannuronate:alginate D-mannuronyltransferase
REACTION    GDP-D-mannuronate + (Alginate)n = GDP + (Alginate)n+1
SUBSTRATE   GDP-D-mannuronate
            (Alginate)n
PRODUCT     GDP
            (Alginate)n+1
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.33
            ExPASy - ENZYME nomenclature database: 2.4.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.33
            BRENDA, the Enzyme Database: 2.4.1.33
///
ENTRY       EC 2.4.1.34
NAME        1,3-beta-Glucan synthase
            1,3-beta-D-Glucan--UDP glucosyltransferase
            UDPglucose--1,3-beta-D-glucan glucosyltransferase
            Callose synthetase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase
REACTION    UDPglucose + (1,3-beta-D-Glucosyl)n = UDP +
            (1,3-beta-D-Glucosyl)n+1
SUBSTRATE   UDPglucose
            (1,3-beta-D-Glucosyl)n
PRODUCT     UDP
            (1,3-beta-D-Glucosyl)n
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SCE: YGR032W(GSC2) YLR342W(FKS1) YMR306W(FKS3)
            SPO: CPS1(cps1) SPAC24C9.07C(spac24c9.07c)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.34
            ExPASy - ENZYME nomenclature database: 2.4.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.34
            BRENDA, the Enzyme Database: 2.4.1.34
///
ENTRY       EC 2.4.1.35
NAME        Phenol beta-glucosyltransferase
            UDPglucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:phenol beta-D-glucosyltransferase
REACTION    UDPglucose + a Phenol = UDP + an Aryl beta-D-glucoside
SUBSTRATE   UDPglucose
            Phenol
PRODUCT     UDP
            Aryl beta-D-glucoside
COMMENT     Acts on a wide range of phenols.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.35
            ExPASy - ENZYME nomenclature database: 2.4.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.35
            BRENDA, the Enzyme Database: 2.4.1.35
///
ENTRY       EC 2.4.1.36
NAME        alpha,alpha-Trehalose-phosphate synthase (GDP-forming)
            GDPglucose--glucose-phosphate glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase
REACTION    GDPglucose + D-Glucose 6-phosphate = GDP +
            alpha,alpha'-Trehalose 6-phosphate
SUBSTRATE   GDPglucose
            D-Glucose 6-phosphate
PRODUCT     GDP
            alpha,alpha'-Trehalose 6-phosphate
COMMENT     See also EC 2.4.1.15.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.36
            ExPASy - ENZYME nomenclature database: 2.4.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.36
            BRENDA, the Enzyme Database: 2.4.1.36
///
ENTRY       EC 2.4.1.37
NAME        Fucosylglycoprotein 3-alpha-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose
REACTION    UDPgalactose + Glycoprotein alpha-L-fucosyl-(1,2)-D-galactose =
            UDP + Glycoprotein alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-
            $(1,2)]-D-galactose
SUBSTRATE   UDPgalactose
            Glycoprotein alpha-L-fucosyl-(1,2)-D-galactose
PRODUCT     UDP
            Glycoprotein alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-
            $galactose
COMMENT     Acts on blood group substance, and can use a number of 2-fucosyl-
            galactosides as acceptors.
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 28(ABO)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.37
            ExPASy - ENZYME nomenclature database: 2.4.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.37
            BRENDA, the Enzyme Database: 2.4.1.37
///
ENTRY       EC 2.4.1.38
NAME        beta-N-Acetylglucosaminylglycopeptide beta-1,4-galactosyl
            $transferase
            UDPgalactose--glycoprotein galactosyltransferase
            Glycoprotein 4-beta-galactosyltransferase
            beta-N-Acetyl-D-glucosaminide beta-1,4-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:N-acetyl-beta-D-glucosaminylglycoprptide
            beta-1,4-galactosyltransferase
REACTION    UDPgalactose + N-Acetyl-beta-D-glucosaminyl-glycopeptide =
            UDP +
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
SUBSTRATE   UDPgalactose
            N-Acetyl-beta-D-glucosaminyl-glycopeptide
PRODUCT     UDP
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
COMMENT     Terminal N-acetyl-beta-D-glucosaminyl residues in polysaccharides,
            glycoproteins and glycopeptides can act as acceptor.
            High activity is shown towards such residues in branched-chain
            polysaccharides when these are linked by beta-1,6-links to
            galactose residues; lower activity towards residues linked to
            galactose by beta-1,3-links. A component of EC 2.4.1.22.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 9334(B4GALT5)
STRUCTURES  PDB: 1FGX  1FR8  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.38
            ExPASy - ENZYME nomenclature database: 2.4.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.38
            BRENDA, the Enzyme Database: 2.4.1.38
            SCOP (Structural Classification of Proteins): 2.4.1.38
///
ENTRY       EC 2.4.1.39
NAME        Steroid N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside
            $17alpha-N-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Estradiol-17alpha 3-D-glucuronoside =
            UDP + 17alpha-(N-Acetyl-D-glucosaminyl)-estradiol 3-D-
            $glucuronoside
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Estradiol-17alpha 3-D-glucuronoside
PRODUCT     UDP
            17alpha-(N-Acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.39
            ExPASy - ENZYME nomenclature database: 2.4.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.39
            BRENDA, the Enzyme Database: 2.4.1.39
///
ENTRY       EC 2.4.1.40
NAME        Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
            A-transferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-(1,2)-D-galactose
            $ 3-N-acetyl-D-galactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine + alpha-L-Fucosyl-(1,2)-D-galactose =
            UDP + N-Acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-
            $(1,2)]-D-galactose
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            alpha-L-Fucosyl-(1,2)-D-galactose
PRODUCT     UDP
            N-Acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-
            $galactose
COMMENT     Acts on blood group substance, and can use a number of 2-fucosyl-
            galactosides as acceptor.
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 28(ABO)
DISEASE     MIM: 110300  ABO blood group
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.40
            ExPASy - ENZYME nomenclature database: 2.4.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.40
            BRENDA, the Enzyme Database: 2.4.1.40
///
ENTRY       EC 2.4.1.41
NAME        Polypeptide N-acetylgalactosaminyltransferase
            Protein-UDP acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl
            $transferase
REACTION    UDP-N-acetyl-D-galactosamine + Polypeptide = UDP +
            N-Acetyl-D-galactosaminyl-polypeptide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            Polypeptide
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-polypeptide
COFACTOR    Manganese
            Calcium
COMMENT     Requires both Mn2+ and Ca2+. The glycosyl residue is transferred
            to threonine or serine hydroxyl groups on the polypeptide core of
            submaxillary mucin, kappa-casein, apofetuin and some other
            acceptors of high molecular mass.
GENES       HSA: 11226(GALNT6) 2589(GALNT1) 2590(GALNT2) 2591(GALNT3)
                 26290(GALNT8) 50614(GALNT9) 51809(GALNT7) 8693(GALNT4)
DISEASE     MIM: 601756  UDP-N-acetyl-alpha-D-galactosamine:polypeptide
            MIM: 602274  UDP-N-acetyl-alpha-D-galactosamine:polypeptide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.41
            ExPASy - ENZYME nomenclature database: 2.4.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.41
            BRENDA, the Enzyme Database: 2.4.1.41
///
ENTRY       EC 2.4.1.42
NAME        Deleted entry
            UDPglucuronate--estriol 17beta-D-glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.42
            ExPASy - ENZYME nomenclature database: 2.4.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.42
///
ENTRY       EC 2.4.1.43
NAME        Polygalacturonate 4-alpha-galacturonosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate
            $ 4-alpha-D-galacturonosyltransferase
REACTION    UDP-D-galacturonate + (1,4-alpha-D-Galacturonosyl)n = UDP +
            (1,4-alpha-D-Galacturonosyl)n+1
SUBSTRATE   UDP-D-galacturonate
            (1,4-alpha-D-Galacturonosyl)n
PRODUCT     UDP
            (1,4-alpha-D-Galacturonosyl)n
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.43
            ExPASy - ENZYME nomenclature database: 2.4.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.43
            BRENDA, the Enzyme Database: 2.4.1.43
///
ENTRY       EC 2.4.1.44
NAME        Lipopolysaccharide galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase
REACTION    UDPgalactose + Lipopolysaccharide = UDP + 1,3-alpha-D-Galactosyl
            $lipopolysaccharide
SUBSTRATE   UDPgalactose
            Lipopolysaccharide
PRODUCT     UDP
            1,3-alpha-D-Galactosyllipopolysaccharide
COMMENT     Transfers D-galactosyl residues to D-glucose in the partially
            completed core of lipopolysaccharide (cf. EC 2.4.1.56, 2.4.1.58
            and 2.4.1.73).
GENES       ECO: b3627(rfaI)
            ECE: Z5053(waaI)
            ECS: ECs4504
STRUCTURES  PDB: 1GA8  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.44
            ExPASy - ENZYME nomenclature database: 2.4.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.44
            BRENDA, the Enzyme Database: 2.4.1.44
            SCOP (Structural Classification of Proteins): 2.4.1.44
///
ENTRY       EC 2.4.1.45
NAME        2-Hydroxyacylsphingosine 1-beta-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl
            $transferase
REACTION    UDPgalactose + 2-(2-Hydroxyacyl)sphingosine = UDP +
            1-(beta-D-Galactosyl)-2-(2-hydroxyacyl)sphingosine
SUBSTRATE   UDPgalactose
            2-(2-Hydroxyacyl)sphingosine
PRODUCT     UDP
            1-(beta-D-Galactosyl)-2-(2-hydroxyacyl)sphingosine
COMMENT     Highly specific.
GENES       MMU: 109522(Ugt8)
            HSA: 7368(UGT8)
MOTIF       PS: PS00375  [FW]-x(2)-Q-x(2)-[LIVMYA]-[LIMV]-x(4,6)-[LVGAC]-
                         [LVFYA]-[LIVMF]-[STAGCM]-[HNQ]-[STAGC]-G-x(2)-[STAG]-
                         x(3)-[STAGL]-[LIVMFA]-x(4)-[PQR]-[LIVMT]-x(3)-[PA]-
                         x(3)-[DES]-[QEHN]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.45
            ExPASy - ENZYME nomenclature database: 2.4.1.45
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.45
            BRENDA, the Enzyme Database: 2.4.1.45
///
ENTRY       EC 2.4.1.46
NAME        1,2-Diacylglycerol 3-beta-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase
REACTION    UDPgalactose + 1,2-Diacylglycerol = UDP +
            3-beta-D-Galactosyl-1,2-diacylglycerol
SUBSTRATE   UDPgalactose
            1,2-Diacylglycerol
PRODUCT     UDP
            3-beta-D-Galactosyl-1,2-diacylglycerol
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.46
            ExPASy - ENZYME nomenclature database: 2.4.1.46
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.46
            BRENDA, the Enzyme Database: 2.4.1.46
///
ENTRY       EC 2.4.1.47
NAME        N-Acylsphingosine galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:N-acylsphingosine D-galactosyltransferase
REACTION    UDPgalactose + N-Acylsphingosine = UDP + D-Galactosylceramide
SUBSTRATE   UDPgalactose
            N-Acylsphingosine
PRODUCT     UDP
            D-Galactosylceramide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.47
            ExPASy - ENZYME nomenclature database: 2.4.1.47
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.47
            BRENDA, the Enzyme Database: 2.4.1.47
///
ENTRY       EC 2.4.1.48
NAME        Heteroglycan alpha-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase
REACTION    GDPmannose + Heteroglycan = GDP + 1,2-alpha-D-Mannosyl
            $heteroglycan or 1,3-alpha-D-Mannosylheteroglycan
SUBSTRATE   GDPmannose
            Heteroglycan
PRODUCT     GDP
            1,2-alpha-D-Mannosylheteroglycan
            1,3-alpha-D-Mannosylheteroglycan
COMMENT     The acceptor is a heteroglycan primer containing mannose,
            galactose and xylose.  1,2- and 1,3-mannosyl bonds are formed.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.48
            ExPASy - ENZYME nomenclature database: 2.4.1.48
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.48
            BRENDA, the Enzyme Database: 2.4.1.48
///
ENTRY       EC 2.4.1.49
NAME        Cellodextrin phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-beta-D-Oligo-D-glucan:orthophosphate alpha-D-
            $glucosyltransferase
REACTION    (1,4-beta-D-Glucosyl)n + Orthophosphate =
            (1,4-beta-D-Glucosyl)n-1 + alpha-D-Glucose 1-phosphate
SUBSTRATE   (1,4-beta-D-Glucosyl)n
            Orthophosphate
PRODUCT     (1,4-beta-D-Glucosyl)n-1
            alpha-D-Glucose 1-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.49
            ExPASy - ENZYME nomenclature database: 2.4.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.49
            BRENDA, the Enzyme Database: 2.4.1.49
///
ENTRY       EC 2.4.1.50
NAME        Procollagen galactosyltransferase
            Hydroxylysine galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:procollagen-5-hydroxy-L-lysine D-
            $galactosyltransferase
REACTION    UDPgalactose + Procollagen 5-hydroxy-L-lysine = UDP +
            Procollagen 5-(D-galactosyl)-L-lysine
SUBSTRATE   UDPgalactose
            Procollagen 5-hydroxy-L-lysine
PRODUCT     UDP
            Procollagen 5-(D-galactosyl)-L-lysine
COMMENT     Probably involved in the synthesis of carbohydrate units in
            complement.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.50
            ExPASy - ENZYME nomenclature database: 2.4.1.50
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.50
            BRENDA, the Enzyme Database: 2.4.1.50
///
ENTRY       EC 2.4.1.51
NAME        Deleted entry
            UDP-N-acetylglucosamine--glycoprotein
            $ N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now listed as EC 2.4.1.101, 2.4.1.143, 2.4.1.144
            and 2.4.1.145.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.51
            ExPASy - ENZYME nomenclature database: 2.4.1.51
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.51
///
ENTRY       EC 2.4.1.52
NAME        Poly(glycerol-phosphate) alpha-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase
REACTION    UDPglucose + Poly(glycerol phosphate) = UDP +
            alpha-D-Glucosylpoly(glycerol phosphate)
SUBSTRATE   UDPglucose
            Poly(glycerol phosphate)
PRODUCT     UDP
            alpha-D-Glucosylpoly(glycerol phosphate)
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       BSU: BG10724(tagE)
            SAV: SAV2632
            SPN: SP1758
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.52
            ExPASy - ENZYME nomenclature database: 2.4.1.52
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.52
            BRENDA, the Enzyme Database: 2.4.1.52
///
ENTRY       EC 2.4.1.53
NAME        Poly(ribitol-phosphate) beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase
REACTION    UDPglucose + Poly(ribitol phosphate) = UDP +
            beta-D-Glucosylpoly(ribitol phosphate)
SUBSTRATE   UDPglucose
            Poly(ribitol phosphate)
PRODUCT     UDP
            beta-D-Glucosylpoly(ribitol phosphate)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.53
            ExPASy - ENZYME nomenclature database: 2.4.1.53
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.53
            BRENDA, the Enzyme Database: 2.4.1.53
///
ENTRY       EC 2.4.1.54
NAME        Undecaprenyl-phosphate mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:undecaprenyl-phosphate D-mannosyltransferase
REACTION    GDPmannose + Undecaprenyl phosphate = GDP +
            beta-D-Glucosyl-1-phosphoundecaprenol
SUBSTRATE   GDPmannose
            Undecaprenyl phosphate
PRODUCT     GDP
            beta-D-Glucosyl-1-phosphoundecaprenol
COFACTOR    Phosphatidylglycerol
COMMENT     Requires phosphatidylglycerol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.54
            ExPASy - ENZYME nomenclature database: 2.4.1.54
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.54
            BRENDA, the Enzyme Database: 2.4.1.54
///
ENTRY       EC 2.4.1.55
NAME        Transferred to EC 2.7.8.14
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Transferred entry. Now EC 2.7.8.14 - CDPribitol
            ribitolphosphotransferase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.55
            ExPASy - ENZYME nomenclature database: 2.4.1.55
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.55
///
ENTRY       EC 2.4.1.56
NAME        Lipopolysaccharide N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:lipopolysaccharide
            N-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Lipopolysaccharide =
            UDP + N-Acetyl-D-glucosaminyllipopolysaccharide
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Lipopolysaccharide
PRODUCT     UDP
            N-Acetyl-D-glucosaminyllipopolysaccharide
COMMENT     Transfers N-acetylglucosaminyl residues to a D-galactose residue
            in the partially completed lipopolysaccharide core (cf. EC
            2.4.1.44, 2.4.1.58 and 2.4.1.73).
GENES       ECO: b3623(rfaK)
            ECE: Z5050(waaD)
            ECS: ECs4501
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.56
            ExPASy - ENZYME nomenclature database: 2.4.1.56
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.56
            BRENDA, the Enzyme Database: 2.4.1.56
///
ENTRY       EC 2.4.1.57
NAME        Phosphatidyl-myo-inositol alpha-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase
REACTION    Transfers one or more alpha-D-mannose units from GDPmannose to
            positions 2,6 and others in 1-phosphatidyl-myo-inositol
SUBSTRATE   GDPmannose
            1-Phosphatidyl-myo-inositol
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.57
            ExPASy - ENZYME nomenclature database: 2.4.1.57
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.57
            BRENDA, the Enzyme Database: 2.4.1.57
///
ENTRY       EC 2.4.1.58
NAME        Lipopolysaccharide glucosyltransferase I
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:lipopolysaccharide glucosyltransferase
REACTION    UDPglucose + Lipopolysaccharide = UDP +
            D-Glucosyllipopolysaccharide
SUBSTRATE   UDPglucose
            Lipopolysaccharide
PRODUCT     UDP
            D-Glucosyllipopolysaccharide
COMMENT     Transfers glucosyl residues to the backbone portion of
            lipopolysaccharide (cf. EC 2.4.1.44, 2.4.1.56, 2.4.1.73).
GENES       ECO: b3626(rfaJ)
            ECE: Z5051(waaJ)
            ECS: ECs4502
            HPY: HP0159(rfaJ)
            HPJ: jhp0147
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.58
            ExPASy - ENZYME nomenclature database: 2.4.1.58
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.58
            BRENDA, the Enzyme Database: 2.4.1.58
///
ENTRY       EC 2.4.1.59
NAME        Deleted entry
            UDPglucuronate--estradiol glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.59
            ExPASy - ENZYME nomenclature database: 2.4.1.59
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.59
///
ENTRY       EC 2.4.1.60
NAME        Abequosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     CDPabequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid
            $ D-abequosyltransferase
REACTION    CDPabequose + D-Mannosyl-L-rhamnosyl-D-galactose-1-
            $diphospholipid = CDP + D-Abequosyl-D-mannosyl-rhamnosyl-D-
            $galactose-1-diphospholipid
SUBSTRATE   CDPabequose
            D-Mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid
PRODUCT     CDP
            D-Abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.60
            ExPASy - ENZYME nomenclature database: 2.4.1.60
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.60
            BRENDA, the Enzyme Database: 2.4.1.60
///
ENTRY       EC 2.4.1.61
NAME        Deleted entry
            UDPglucuronate--estriol 16alpha-glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.61
            ExPASy - ENZYME nomenclature database: 2.4.1.61
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.61
///
ENTRY       EC 2.4.1.62
NAME        Ganglioside galactosyltransferase
            UDPgalactose--ceramide galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-
            $D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-
            $galactosyltransferase
REACTION    UDPgalactose + N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-
            $D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP +
            D-Galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
SUBSTRATE   UDPgalactose
            N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-
            $D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine
PRODUCT     UDP
            D-Galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine
COMMENT     The substrate is also known as GM2.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.62
            ExPASy - ENZYME nomenclature database: 2.4.1.62
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.62
            BRENDA, the Enzyme Database: 2.4.1.62
///
ENTRY       EC 2.4.1.63
NAME        Linamarin synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-
            $glucosyltransferase
REACTION    UDPglucose + 2-Hydroxy-2-methylpropanenitrile = UDP + Linamarin
SUBSTRATE   UDPglucose
            2-Hydroxy-2-methylpropanenitrile
PRODUCT     UDP
            Linamarin
COMMENT     The enzyme glucosylates the cyanhydrins of butanone and pentan-
            -3-one as well as that of acetone.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.63
            ExPASy - ENZYME nomenclature database: 2.4.1.63
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.63
            BRENDA, the Enzyme Database: 2.4.1.63
///
ENTRY       EC 2.4.1.64
NAME        alpha,alpha-Trehalose phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     alpha,alpha-Trehalose:orthophosphate beta-D-glucosyltransferase
REACTION    alpha,alpha'-Trehalose + Orthophosphate = D-Glucose +
            beta-D-Glucose 1-phosphate
SUBSTRATE   alpha,alpha'-Trehalose
            Orthophosphate
PRODUCT     D-Glucose
            beta-D-Glucose 1-phosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.64
            ExPASy - ENZYME nomenclature database: 2.4.1.64
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.64
            BRENDA, the Enzyme Database: 2.4.1.64
///
ENTRY       EC 2.4.1.65
NAME        Galactoside 3(4)-L-fucosyltransferase
            Blood group Lewis alpha-4-fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-L-fucose:beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
            4-fucosyltransferase
REACTION    GDP-L-fucose + 1,3-beta-D-Galactosyl-N-acetyl-D-glucosaminyl-R =
            GDP + 1,3-beta-D-Galactosyl-(alpha-1,4-L-fucosyl)-N-
            $acetyl-D-glucosaminyl-R
SUBSTRATE   GDP-L-fucose
            1,3-beta-D-Galactosyl-N-acetyl-D-glucosaminyl-R
            1,4-beta-D-Galactosyl-N-acetyl-D-glucosaminyl-R
PRODUCT     GDP
            1,3-beta-D-Galactosyl-(alpha-1,4-L-fucosyl)-N-acetyl-
            $D-glucosaminyl-R
            1,4-beta-D-Galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-
            $D-glucosaminyl-R
COMMENT     Also acts on the corresponding 1,4-galactosyl derivative,
            forming 1,3-L-fucosyl links (cf. EC 2.4.1.69 and 2.4.1.152).
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 2525(FUT3) 2527(FUT5) 2528(FUT6)
DISEASE     MIM: 111100  Fucosyltransferase 3 (galactoside
                         3(4)-L-fucosyltransferase; Lewis
            MIM: 136835  Fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
            MIM: 136836  Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.65
            ExPASy - ENZYME nomenclature database: 2.4.1.65
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.65
            BRENDA, the Enzyme Database: 2.4.1.65
///
ENTRY       EC 2.4.1.66
NAME        Procollagen glucosyltransferase
            Galactosylhydroxylysine-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen
            $ D-glucosyltransferase
REACTION    UDPglucose + 5-(D-Galactosyloxy)-L-lysine-procollagen = UDP +
            1,2-D-Glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
SUBSTRATE   UDPglucose
            5-(D-Galactosyloxy)-L-lysine-procollagen
PRODUCT     UDP
            1,2-D-Glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
COMMENT     Probably involved in the synthesis of carbohydrate units in
            complement (cf. EC 2.4.1.50).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.66
            ExPASy - ENZYME nomenclature database: 2.4.1.66
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.66
            BRENDA, the Enzyme Database: 2.4.1.66
///
ENTRY       EC 2.4.1.67
NAME        Galactinol--raffinose galactosyltransferase
            Stachyose synthetase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1-alpha-D-Galactosyl-myo-inositol:raffinose galactosyltransferase
REACTION    1-alpha-D-Galactosyl-myo-inositol + Raffinose = myo-Inositol +
            Stachyose
SUBSTRATE   1-alpha-D-Galactosyl-myo-inositol
            Raffinose
PRODUCT     myo-Inositol
            Stachyose
COMMENT     cf. EC 2.4.1.123.
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.67
            ExPASy - ENZYME nomenclature database: 2.4.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.67
            BRENDA, the Enzyme Database: 2.4.1.67
///
ENTRY       EC 2.4.1.68
NAME        Glycoprotein 6-alpha-L-fucosyltransferase
            GDPfucose--glycoprotein fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked
            $ N-acetylglucosamine of N-acetyl-beta-D-glucosaminyl-1,2-alpha-
            $D-mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-
            $D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine 6-alpha-L-
            $fucosyltransferase
REACTION    GDP-L-fucose + N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,3-(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-
            $D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl)asparagine = GDP +
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
            $1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
SUBSTRATE   GDP-L-fucose
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-beta-N-acetyl-1,4-D-glucosaminyl-
            $1,4-N-acetyl-D-glucosaminyl)asparagine
PRODUCT     GDP
            N4-(N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-
            $(R1-alpha-1,6)-beta-D-mannosyl-1,4-beta-N-acetyl-D-glucosaminyl-
            $1,4-(alpha-L-fucosyl-1,6)-N-acetyl-D-glucosaminyl)asparagine
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.68
            ExPASy - ENZYME nomenclature database: 2.4.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.68
            BRENDA, the Enzyme Database: 2.4.1.68
///
ENTRY       EC 2.4.1.69
NAME        Galactoside 2-L-fucosyltransferase
            Blood group H alpha-2-fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-L-fucose:beta-D-galactosyl-R 2-fucosyltransferase
REACTION    GDP-L-fucose + beta-D-galactosyl-R = GDP +
            alpha-L-Fucosyl-1,2-beta-D-galactosyl-R
SUBSTRATE   GDP-L-fucose
            beta-D-galactosyl-R
            Lactose
PRODUCT     GDP
            alpha-L-Fucosyl-1,2-beta-D-galactosyl-R
COMMENT     Lactose can act as acceptor. The action on glycolipid was
            previously listed as EC 2.4.1.89. (cf. EC 2.4.1.65 and 2.4.1.152)
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 2523(FUT1) 2524(FUT2)
DISEASE     MIM: 182100  Fucosyltransferase-2 (secretor)
            MIM: 211100  Fucosyltransferase-1 (Bombay phenotype)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.69
            ExPASy - ENZYME nomenclature database: 2.4.1.69
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.69
            BRENDA, the Enzyme Database: 2.4.1.69
///
ENTRY       EC 2.4.1.70
NAME        Poly(ribitol-phosphate) N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate)
            $ N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Poly(ribitol phosphate) = UDP +
            N-Acetyl-D-glucosaminyl-poly(ribitol phosphate)
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Poly(ribitol phosphate)
PRODUCT     UDP
            N-Acetyl-D-glucosaminyl-poly(ribitol phosphate)
COMMENT     Involved in the synthesis of teichoic acids.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.70
            ExPASy - ENZYME nomenclature database: 2.4.1.70
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.70
            BRENDA, the Enzyme Database: 2.4.1.70
///
ENTRY       EC 2.4.1.71
NAME        Arylamine glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:arylamine N-D-glucosyltransferase
REACTION    UDPglucose + an Arylamine = UDP + an N-D-Glucosylarylamine
SUBSTRATE   UDPglucose
            Arylamine
PRODUCT     UDP
            N-D-Glucosylarylamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.71
            ExPASy - ENZYME nomenclature database: 2.4.1.71
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.71
            BRENDA, the Enzyme Database: 2.4.1.71
///
ENTRY       EC 2.4.1.72
NAME        Transferred to EC 2.4.2.24
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Transferred entry. Now EC 2.4.2.24 - 1,4-beta-D-Xylan synthase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.72
            ExPASy - ENZYME nomenclature database: 2.4.1.72
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.72
///
ENTRY       EC 2.4.1.73
NAME        Lipopolysaccharide glucosyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:galactosyl-lipopolysaccharide alpha-D-
            $glucosyltransferase
REACTION    UDPglucose + Lipopolysaccharide = UDP + alpha-D-Glucosyl
            $lipopolysaccharide
SUBSTRATE   UDPglucose
            Lipopolysaccharide
PRODUCT     UDP
            alpha-D-Glucosyllipopolysaccharide
COMMENT     Transfers glucosyl residues to the D-galactosyl-D-glucosyl
            side-chains in the partially completed core of
            lipopolysaccharides. cf. EC 2.4.1.44, 2.4.1.56 and 2.4.1.58.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.73
            ExPASy - ENZYME nomenclature database: 2.4.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.73
            BRENDA, the Enzyme Database: 2.4.1.73
///
ENTRY       EC 2.4.1.74
NAME        Glycosaminoglycan galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:glycosaminoglycan D-galactosyltransferase
REACTION    UDPgalactose + Glycosaminoglycan = UDP +
            D-Galactosylglycosaminoglycan
SUBSTRATE   UDPgalactose
            Glycosaminoglycan
PRODUCT     UDP
            D-Galactosylglycosaminoglycan
COMMENT     Involved in the biosynthesis of galactose-containing
            glycosaminoglycan of Dictostelium discoideum.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.74
            ExPASy - ENZYME nomenclature database: 2.4.1.74
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.74
            BRENDA, the Enzyme Database: 2.4.1.74
///
ENTRY       EC 2.4.1.75
NAME        UDPgalacturonosyltransferase
            p-Nitrophenol conjugating enzyme
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalacturonate beta-D-galacturonosyltransferase
            $ (acceptor-unspecific)
REACTION    UDPgalacturonate + Acceptor = UDP + Acceptor beta-D-galacturonide
SUBSTRATE   UDPgalacturonate
            Acceptor
PRODUCT     UDP
            Acceptor beta-D-galacturonide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.75
            ExPASy - ENZYME nomenclature database: 2.4.1.75
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.75
            BRENDA, the Enzyme Database: 2.4.1.75
///
ENTRY       EC 2.4.1.76
NAME        Deleted entry
            UDPglucuronate--bilirubin glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.76
            ExPASy - ENZYME nomenclature database: 2.4.1.76
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.76
///
ENTRY       EC 2.4.1.77
NAME        Deleted entry
            UDPglucuronate--bilirubin-glucuronoside glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.77
            ExPASy - ENZYME nomenclature database: 2.4.1.77
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.77
///
ENTRY       EC 2.4.1.78
NAME        Phosphopolyprenol glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:phosphopolyprenol D-glucosyltransferase
REACTION    UDPglucose + Polyprenyl phosphate = UDP +
            Polyprenylphosphate-glucose
SUBSTRATE   UDPglucose
            Polyprenyl phosphate
PRODUCT     UDP
            Polyprenylphosphate-glucose
COMMENT     Ficaprenyl phosphate is the best substrate, other polyprenols act,
            more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.78
            ExPASy - ENZYME nomenclature database: 2.4.1.78
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.78
            BRENDA, the Enzyme Database: 2.4.1.78
///
ENTRY       EC 2.4.1.79
NAME        Galactosylgalactosylglucosylceramide
            $ beta-D-acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-
            $glucosylceramide beta-N-acetyl-D-galactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine +
            D-Galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide = UDP +
            N-Acetyl-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-
            $1,4-D-glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            D-Galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-
            $1,4-D-glucosylceramide
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.79
            ExPASy - ENZYME nomenclature database: 2.4.1.79
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.79
            BRENDA, the Enzyme Database: 2.4.1.79
///
ENTRY       EC 2.4.1.80
NAME        Ceramide glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:N-acylsphingosine D-glucosyltransferase
REACTION    UDPglucose + N-Acylsphingosine = UDP +
            D-Glucosyl-N-acylsphingosine
SUBSTRATE   UDPglucose
            N-Acylsphingosine
            Sphingosine
            Dihydrosphingosine
            CDPglucose
PRODUCT     UDP
            D-Glucosyl-N-acylsphingosine
            D-Glucosylsphingosine
            D-Glucosyldihydrosphingosine
            CDP
COMMENT     Sphingosine and dihydrosphingosine can also act as acceptors;
            CDPglucose can act as donor.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       YPE: YPO1983
            MLO: mlr5650
            SYN: slr0813
            DME: CG6437
            HSA: 7357(UGCG)
DISEASE     MIM: 602874  UDP-glucose ceramide glucosyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.80
            ExPASy - ENZYME nomenclature database: 2.4.1.80
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.80
            BRENDA, the Enzyme Database: 2.4.1.80
///
ENTRY       EC 2.4.1.81
NAME        Flavone 7-O-beta-glucosyltransferase
            UDPglucose--apigenin beta-glucosyltransferase
            UDPglucose--luteolin beta-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:5,7,3',4'-tetrahydroflavone
            7-O-beta-D-glucosyltransferase
REACTION    UDPglucose + 5,7,3',4'-Tetrahydroflavone = UDP +
            7-O-beta-D-Glucosyl-5,7,3',4'-tetrahydroflavone
SUBSTRATE   UDPglucose
            5,7,3',4'-Tetrahydroflavone
PRODUCT     UDP
            7-O-beta-D-Glucosyl-5,7,3',4'-tetrahydroflavone
COMMENT     A number of flavones, flavonones and flavonols can function as
            acceptors.  Different from EC 2.4.1.91.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.81
            ExPASy - ENZYME nomenclature database: 2.4.1.81
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.81
            BRENDA, the Enzyme Database: 2.4.1.81
///
ENTRY       EC 2.4.1.82
NAME        Galactinol--sucrose galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1-alpha-D-Galactosyl-myo-inositol:sucrose 6-alpha-D-
            $galactosyltransferase
REACTION    1-alpha-D-Galactosyl-myo-inositol + Sucrose = myo-Inositol +
            Raffinose
SUBSTRATE   1-alpha-D-Galactosyl-myo-inositol
            Sucrose
            4-Nitrophenol-alpha-D-galactopyranoside
PRODUCT     myo-Inositol
            Raffinose
COMMENT     4-Nitrophenol-alpha-D-galactopyranoside can also act as donor.
            The enzyme also catalyses an exchange reaction between raffinose
            and sucrose (cf. EC 2.4.1.123).
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.82
            ExPASy - ENZYME nomenclature database: 2.4.1.82
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.82
            BRENDA, the Enzyme Database: 2.4.1.82
///
ENTRY       EC 2.4.1.83
NAME        Dolichyl-phosphate beta-D-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:dolichyl-phosphate O-beta-D-mannosyltransferase
REACTION    GDPmannose + Dolichyl phosphate = GDP +
            Dolichyl D-mannosyl phosphate
SUBSTRATE   GDPmannose
            Dolichyl phosphate
            Polyprenyl phosphate
PRODUCT     GDP
            Dolichyl D-mannosyl phosphate
COMMENT     Acts only on long-chain polyprenyl phosphates and alpha-dihydro-
            polyprenyl phosphates, larger than C35.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       MLO: mll5672
            BSU: BG13230(ykcC)
            CAC: CAC0194 CAC3661
            SYN: sll1540(dpm1) slr1943(dpm1)
            AAE: aq_1899(dmt)
            MJA: MJ0544 MJ1222
            MTH: MTH374 MTH377
            TAC: Ta0760
            TVO: TVG0887952
            PHO: PH0051
            PAB: PAB2307
            APE: APE0426
            SSO: SSO3241
            SCE: YPR183W(DPM1)
            SPO: DPM1(dpm1)
            DME: CG10166
            HSA: 8813(DPM1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.83
            ExPASy - ENZYME nomenclature database: 2.4.1.83
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.83
            BRENDA, the Enzyme Database: 2.4.1.83
///
ENTRY       EC 2.4.1.84
NAME        Deleted entry
            UDPglucuronate--1,2-diacylglycerol glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.84
            ExPASy - ENZYME nomenclature database: 2.4.1.84
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.84
///
ENTRY       EC 2.4.1.85
NAME        Cyanohydrin beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase
REACTION    UDPglucose + (S)-4-Hydroxymandelonitrile = UDP +
            (S)-4-Hydroxymandelonitrile beta-D-glucoside
SUBSTRATE   UDPglucose
            (S)-4-Hydroxymandelonitrile
            (S)-Mandelonitrile
PRODUCT     UDP
            (S)-4-Hydroxymandelonitrile beta-D-glucoside
            (S)-Mandelonitrile beta-D-glucoside
COMMENT     Also acts on (S)-mandelonitrile.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.85
            ExPASy - ENZYME nomenclature database: 2.4.1.85
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.85
            BRENDA, the Enzyme Database: 2.4.1.85
///
ENTRY       EC 2.4.1.86
NAME        Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-
            $1,4-D-glucosylceramide beta-D-galactosyltransferase
REACTION    UDPgalactose + N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-
            $D-glucosylceramide = UDP + 1,3-beta-D-Galactosyl-N-acetyl-
            $D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
SUBSTRATE   UDPgalactose
            N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-
            $glucosylceramide
PRODUCT     UDP
            1,3-beta-D-Galactosyl-N-acetyl-D-glucosaminyl-1,3-beta-D-
            $galactosyl-1,4-D-glucosylceramide
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.86
            ExPASy - ENZYME nomenclature database: 2.4.1.86
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.86
            BRENDA, the Enzyme Database: 2.4.1.86
///
ENTRY       EC 2.4.1.87
NAME        beta-Galactosyl-N-acetylglucosaminylglycopeptide
            $ alpha-1,3-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-
            $glycopeptide alpha-1,3-D-galactosyltransferase
REACTION    UDPgalactose +
            beta-D-Galactosyl-beta-1,4-N-acetyl-D-glucosaminylglycopeptide =
            UDP +
            alpha-D-Galactosyl-1,3-D-galactosylbeta-1,4-N-acetyglucosaminyl-
            $glycopeptide
SUBSTRATE   UDPgalactose
            beta-D-Galactosyl-beta-1,4-N-acetyl-D-glucosaminylglycopeptide
PRODUCT     UDP
            alpha-D-Galactosyl-1,3-D-galactosylbeta-1,4-N-acetyglucosaminyl-
            $glycopeptide
COMMENT     cf. EC 2.4.1.38.
PATHWAY     PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.87
            ExPASy - ENZYME nomenclature database: 2.4.1.87
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.87
            BRENDA, the Enzyme Database: 2.4.1.87
///
ENTRY       EC 2.4.1.88
NAME        Globoside alpha-N-acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-
            $1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
            $alpha-N-acetylgalactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine + N-Acetyl-D-galactosaminyl-
            $1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide = UDP +
            N-Acetyl-D-galactosaminyl-N-Acetyl-D-galactosaminyl-
            $1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            N-Acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-
            $1,4-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-N-Acetyl-D-galactosaminyl-
            $1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: 26301
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.88
            ExPASy - ENZYME nomenclature database: 2.4.1.88
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.88
            BRENDA, the Enzyme Database: 2.4.1.88
///
ENTRY       EC 2.4.1.89
NAME        Deleted entry
            Galactosylglucosaminylgalactosylglucosylceramide
            $ alpha-L-fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.69.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.89
            ExPASy - ENZYME nomenclature database: 2.4.1.89
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.89
///
ENTRY       EC 2.4.1.90
NAME        N-Acetyllactosamine synthase
            UDPgalactose-N--acetylglucosamine beta-D-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
REACTION    UDPgalactose + N-Acetyl-D-glucosamine = UDP + N-Acetyllactosamine
SUBSTRATE   UDPgalactose
            N-Acetyl-D-glucosamine
PRODUCT     UDP
            N-Acetyllactosamine
COMMENT     The reaction is catalysed by a component of EC 2.4.1.22, which is
            identical with EC 2.4.1.38, and by an enzyme from the Golgi
            apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
DISEASE     MIM: 137060  Glycoprotein-4-beta-galactosyltransferase-2 (EC
                         2.4.1.22)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.90
            ExPASy - ENZYME nomenclature database: 2.4.1.90
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.90
            BRENDA, the Enzyme Database: 2.4.1.90
///
ENTRY       EC 2.4.1.91
NAME        Flavonol 3-O-glucosyltransferase
            GTI
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:flavonol 3-O-D-glucosyltransferase
REACTION    UDPglucose + a Flavonol = UDP + Flavonol 3-O-D-glucoside
SUBSTRATE   UDPglucose
            Flavonol
            Quercetin
            Quercetin 7-O-glucoside
PRODUCT     UDP
            Flavonol 3-O-D-glucoside
COMMENT     Acts on variety of flavonols, including quercetin and
            quercetin 7-O-glucoside. Different from EC 2.4.1.81.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
MOTIF       PS: PS00375  [FW]-x(2)-Q-x(2)-[LIVMYA]-[LIMV]-x(4,6)-[LVGAC]-
                         [LVFYA]-[LIVMF]-[STAGCM]-[HNQ]-[STAGC]-G-x(2)-[STAG]-
                         x(3)-[STAGL]-[LIVMFA]-x(4)-[PQR]-[LIVMT]-x(3)-[PA]-
                         x(3)-[DES]-[QEHN]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.91
            ExPASy - ENZYME nomenclature database: 2.4.1.91
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.91
            BRENDA, the Enzyme Database: 2.4.1.91
///
ENTRY       EC 2.4.1.92
NAME        (N-Acetylneuraminyl)-galactosylglucosylceramide
            $ N-acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-
            -D-glucosylceramide N-acetyl-D-galactrosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine +
            (N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide =
            UDP + N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            (N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       MMU: 95703(Ggm2)
            HSA: 2583(GALGT)
DISEASE     MIM: 601873 
                         UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.92
            ExPASy - ENZYME nomenclature database: 2.4.1.92
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.92
            BRENDA, the Enzyme Database: 2.4.1.92
///
ENTRY       EC 2.4.1.93
NAME        Inulin fructotransferase (depolymerizing,
            difructofuranose-1,2':2,3'-dianhydride-forming)
            Inulin fructotransferase (DFA-III-producing)
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-
            -forming)
REACTION    Removes successive terminal D-fructosyl-D-fructofuranosyl groups
            from inulin as the cyclic 1,2':2,3'-dianhydride, leaving a
            residual di- or trisaccharide
SUBSTRATE   Inulin
PRODUCT     D-Fructofuranose 1,2':2,3'-dianhydride
COMMENT     cf. EC 1.1.1.200.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.93
            ExPASy - ENZYME nomenclature database: 2.4.1.93
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.93
            BRENDA, the Enzyme Database: 2.4.1.93
///
ENTRY       EC 2.4.1.94
NAME        Protein N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:
            $protein beta-N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Protein = UDP +
            4-N-(N-Acetyl-D-glucosaminyl)-protein
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Protein
PRODUCT     UDP
            4-N-(N-Acetyl-D-glucosaminyl)-protein
COMMENT     The acceptor is the asparagine residue in a sequence of the form
            Asn-Xaa-Thr or Asn-Xaa-Ser.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.94
            ExPASy - ENZYME nomenclature database: 2.4.1.94
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.94
            BRENDA, the Enzyme Database: 2.4.1.94
///
ENTRY       EC 2.4.1.95
NAME        Bilirubin-glucuronoside glucuronosyltransferase
            Bilirubin monoglucuronide transglucuronidase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Bilirubin-glucuronoside:
            $bilirubin-glucuronoside D-glucuronosyltransferase
REACTION    2 Bilirubin-glucuronoside = Bilirubin +
            Bilirubin-bisglucuronoside
SUBSTRATE   Bilirubin-glucuronoside
PRODUCT     Bilirubin
            Bilirubin-bisglucuronoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.95
            ExPASy - ENZYME nomenclature database: 2.4.1.95
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.95
            BRENDA, the Enzyme Database: 2.4.1.95
///
ENTRY       EC 2.4.1.96
NAME        sn-Glycerol-3-phosphate 1-galactosyltransferase
            Isofloridoside-phosphate synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:
            $sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase
REACTION    UDPgalactose + sn-Glycerol 3-phosphate = UDP +
            alpha-D-Galactosyl-(1,1')-sn-glycerol 3-phosphate
SUBSTRATE   UDPgalactose
            sn-Glycerol 3-phosphate
PRODUCT     UDP
            alpha-D-Galactosyl-(1,1')-sn-glycerol 3-phosphate
COMMENT     The product is hydrolysed by a phosphatase to isofloridosides,
            which is incolved in osmoregulation (cf. EC 2.4.1.137).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.96
            ExPASy - ENZYME nomenclature database: 2.4.1.96
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.96
            BRENDA, the Enzyme Database: 2.4.1.96
///
ENTRY       EC 2.4.1.97
NAME        1,3-beta-Glucan phosphorylase
            Laminarin phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,3-beta-D-Glucan:orthophosphate alpha-D-glucosyltransferase
REACTION    (1,3-beta-D-Glucosyl)n + Orthophosphate =
            (1,3-beta-D-Glucosyl)n-1 + alpha-D-Glucose 3-phosphate
SUBSTRATE   (1,3-beta-D-Glucosyl)n
            Orthophosphate
PRODUCT     (1,3-beta-D-Glucosyl)n-1
            alpha-D-Glucose 3-phosphate
COMMENT     Acts on a range of beta-1,3-oligoglucans, and on glucans of
            laminarin type.  Different from EC 2.4.1.30 and 2.4.1.31.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.97
            ExPASy - ENZYME nomenclature database: 2.4.1.97
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.97
            BRENDA, the Enzyme Database: 2.4.1.97
///
ENTRY       EC 2.4.1.98
NAME        Deleted entry
            UDPgalactose--N-acetylglucosamine beta-D-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.90.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.98
            ExPASy - ENZYME nomenclature database: 2.4.1.98
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.98
///
ENTRY       EC 2.4.1.99
NAME        Sucrose 1F-fructosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:sucrose 1F-beta-D-fructosyltransferase
REACTION    2 Sucrose = D-Glucose + 1F-beta-D-Fructosylsucrose
SUBSTRATE   Sucrose
PRODUCT     D-Glucose
            1F-beta-D-Fructosylsucrose
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.99
            ExPASy - ENZYME nomenclature database: 2.4.1.99
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.99
            BRENDA, the Enzyme Database: 2.4.1.99
///
ENTRY       EC 2.4.1.100
NAME        1,2-beta-Fructan 1F-fructosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,2-beta-D-Fructan:
            $ 1,2-beta-D-fructan 1F-beta-D-fructosyltransferase
REACTION    (1,2-beta-D-Fructosyl)m + (1,2-beta-D-Fructosyl)n =
            (1,2-beta-D-Fructosyl)m-1 + (1,2-beta-D-Fructosyl)n+1
SUBSTRATE   (1,2-beta-D-Fructosyl)m
            (1,2-beta-D-Fructosyl)n
PRODUCT     (1,2-beta-D-Fructosyl)m-1
            (1,2-beta-D-Fructosyl)n+1
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.100
            ExPASy - ENZYME nomenclature database: 2.4.1.100
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.100
            BRENDA, the Enzyme Database: 2.4.1.100
///
ENTRY       EC 2.4.1.101
NAME        alpha-1,3-Mannosyl-glycoprotein beta-1,2-N-acetyl-
            $glucosaminyltransferase
            N-Glycosyl-oligosaccharide-glycoprotein N-acetyl-
            $glucosaminyltransferase I
            N-Acetylglucosaminyltransferase I
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein(N-acetyl-D-glucosamine
            to alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2) beta-1,2-N-
            $acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            alpha-D-Mannosyl-1,3-(R1)-beta-D-mannosyl-R2 =
            UDP + N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-
            $1,3-(R1)-beta-D-mannosyl-R2
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            alpha-D-Mannosyl-1,3-(R1)-beta-D-mannosyl-R2
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-
            $1,3-(R1)-beta-D-mannosyl-R2
COMMENT     Acceptor is the 'core' oligosaccharide of glycoprotein
            N-oligosaccharides contarining 2-N-acetyl-D-glucosamine
            and 3-5 D-mannose residues, +/- one L-fucose (cf. EC 2.4.1.143-5
            and 2.4.1.155).
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       CEL: B0416.6 M01F1.1
            DME: CG13431(MGAT1)
            MMU: 96973(Mgat1)
            HSA: 4245(MGAT1)
DISEASE     MIM: 160995  Mannosyl (alpha-1,3-)-glycoprotein beta-1,2,
STRUCTURES  PDB: 1FO9  1FOA  1FO8  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.101
            ExPASy - ENZYME nomenclature database: 2.4.1.101
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.101
            BRENDA, the Enzyme Database: 2.4.1.101
///
ENTRY       EC 2.4.1.102
NAME        beta-1,3-Galactosyl-O-glycosyl-glycoprotein
            $ beta-1,6-N-acetylglucosaminyltransferase
            O-glycosyl-oligosaccharide-glycoprotein
            $ N-acetylglucosaminyltransferase I
            beta6-N-Acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-
            $D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-
            $1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-
            $glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            beta-D-Galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP +
            beta-D-Galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-
            $D-galactosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            beta-D-Galactosyl-1,3-N-acetyl-D-galactosaminyl-R
PRODUCT     UDP
            beta-D-Galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-
            $D-galactosaminyl-R
COMMENT     cf. EC 2.4.1.146, EC 2.4.1.147 and EC 2.4.1.148.
GENES       HSA: 2650(GCNT1)
DISEASE     MIM: 600391  Glucosaminyl (N-acetyl) transferase 1, core 2
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.102
            ExPASy - ENZYME nomenclature database: 2.4.1.102
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.102
            BRENDA, the Enzyme Database: 2.4.1.102
///
ENTRY       EC 2.4.1.103
NAME        Alizarin 2-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:
            $1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Alizarin = UDP +
            1-Hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone
SUBSTRATE   UDPglucose
            Alizarin
PRODUCT     UDP
            1-Hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone
COMMENT     Acts on other hydroxy- and dihydroxy-derivatives of
            9,10-anthraquinone
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.103
            ExPASy - ENZYME nomenclature database: 2.4.1.103
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.103
            BRENDA, the Enzyme Database: 2.4.1.103
///
ENTRY       EC 2.4.1.104
NAME        o-Dihydroxycoumarin 7-O-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase
REACTION    UDPglucose + 7,8-Dihydroxycoumarin = UDP + Daphnin
SUBSTRATE   UDPglucose
            7,8-Dihydroxycoumarin
PRODUCT     UDP
            Daphnin
COMMENT     Converts the glycone daphetin into daphnin and, more slowly,
            esculetin into cichoriin, umbelliferone into skimmin,
            hydragetin into hydrangin and scopoletin into scopolin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.104
            ExPASy - ENZYME nomenclature database: 2.4.1.104
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.104
            BRENDA, the Enzyme Database: 2.4.1.104
///
ENTRY       EC 2.4.1.105
NAME        Vitexin beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Vitexin = Vitexin 2''-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            Vitexin
PRODUCT     Vitexin 2''-O-beta-D-glucoside
COMMENT     Vitexin is a flavonoid from Cannabis sativa and some populations
            of Silex alba.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.105
            ExPASy - ENZYME nomenclature database: 2.4.1.105
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.105
            BRENDA, the Enzyme Database: 2.4.1.105
///
ENTRY       EC 2.4.1.106
NAME        Isovitexin beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Isovitexin  = Isovitexin 2''-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            Isovitexin
PRODUCT     Isovitexin 2''-O-beta-D-glucoside
COMMENT     Isovitexin is a flavonoid from petals of Silex alba.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.106
            ExPASy - ENZYME nomenclature database: 2.4.1.106
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.106
            BRENDA, the Enzyme Database: 2.4.1.106
///
ENTRY       EC 2.4.1.107
NAME        Deleted entry
            UDPglucuronate--testosterone glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.107
            ExPASy - ENZYME nomenclature database: 2.4.1.107
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.107
///
ENTRY       EC 2.4.1.108
NAME        Deleted entry
            UDPglucuronate--phenol glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
COMMENT     Deleted entry. Now included with EC 2.4.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.108
            ExPASy - ENZYME nomenclature database: 2.4.1.108
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.108
///
ENTRY       EC 2.4.1.109
NAME        Dolichyl-phosphate-mannose--protein mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
REACTION    Dolichyl phosphate D-mannose + Protein = Dolichyl phosphate +
            O-D-Mannosylprotein
SUBSTRATE   Dolichyl phosphate D-mannose
            Protein
PRODUCT     Dolichyl phosphate
            O-D-Mannosylprotein
COMMENT     The enzyme transfers mannosyl residues to the hydroxyl of serine
            or threonine residues, producing cell-wall mannoproteins.  It
            acts only on long-chain alpha-dihydroxyprenyl derivatives, larger
            than C35.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YAL023C(PMT2) YDL093W(PMT5) YDL095W(PMT1) YDR307W
                 YGR199W(PMT6) YJR143C(PMT4) YOR321W(PMT3)
            SPO: SPAC22A12.07C(spac22a12.07c) SPBC16C6.09(spbc16c6.09)
            DME: CG12311(EG:34F3.7)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.109
            ExPASy - ENZYME nomenclature database: 2.4.1.109
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.109
            BRENDA, the Enzyme Database: 2.4.1.109
///
ENTRY       EC 2.4.1.110
NAME        tRNA-queuosine beta-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:tRNA(Asp)-quenosine O-5''-beta-D-mannosyltransferase
REACTION    GDPmannose + tRNA(Asp)-quenosine = GDP +
            tRNA(Asp)-O-5''-beta-D-mannosylquenosine
SUBSTRATE   GDPmannose
            tRNA(Asp)-quenosine
PRODUCT     GDP
            tRNA(Asp)-O-5''-beta-D-mannosylquenosine
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.110
            ExPASy - ENZYME nomenclature database: 2.4.1.110
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.110
            BRENDA, the Enzyme Database: 2.4.1.110
///
ENTRY       EC 2.4.1.111
NAME        Coniferyl-alcohol glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase
REACTION    UDPglucose + Coniferyl alcohol = UDP + Coniferin
SUBSTRATE   UDPglucose
            Coniferyl alcohol
PRODUCT     UDP
            Coniferin
COMMENT     Sinapyl alcohol can also act as acceptor.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.111
            ExPASy - ENZYME nomenclature database: 2.4.1.111
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.111
            BRENDA, the Enzyme Database: 2.4.1.111
///
ENTRY       EC 2.4.1.112
NAME        alpha-1,4-Glucan-protein synthase (ADP-forming)
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:protein 4-alpha-glucosyltransferase
REACTION    UDPglucose + Protein = ADP + alpha-D-Glucosyl-protein
SUBSTRATE   UDPglucose
            Protein
PRODUCT     ADP
            alpha-D-Glucosyl-protein
COMMENT     The enzyme builds up alpha-1,4-glucan chains covalently bound to
            protein thus acting as an initiator of glycogen synthesis.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.112
            ExPASy - ENZYME nomenclature database: 2.4.1.112
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.112
            BRENDA, the Enzyme Database: 2.4.1.112
///
ENTRY       EC 2.4.1.113
NAME        alpha-1,4-Glucan-protein synthase (ADP-forming)
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     ADPglucose:protein 4-alpha-D-glucosyltransferase
REACTION    ADPglucose + Protein = ADP + alpha-D-Glucosyl-protein
SUBSTRATE   ADPglucose
            Protein
PRODUCT     ADP
            alpha-D-Glucosyl-protein
COMMENT     The enzyme builds up alpha-1,4-glucan chains covalently bound to
            protein thus acting as an initiator of glycogen synthesis.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.113
            ExPASy - ENZYME nomenclature database: 2.4.1.113
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.113
            BRENDA, the Enzyme Database: 2.4.1.113
///
ENTRY       EC 2.4.1.114
NAME        2-Coumarate O-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase
REACTION    UDPglucose + trans-2-Hydroxycinnamate = UDP +
            trans-beta-D-Glucosyl-2-hydroxycinnamate
SUBSTRATE   UDPglucose
            trans-2-Hydroxycinnamate
PRODUCT     UDP
            trans-beta-D-Glucosyl-2-hydroxycinnamate
COMMENT     Coumarinate (cis-2--hydroxycinnamate) does not act as acceptor.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.114
            ExPASy - ENZYME nomenclature database: 2.4.1.114
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.114
            BRENDA, the Enzyme Database: 2.4.1.114
///
ENTRY       EC 2.4.1.115
NAME        Anthocyanidin 3-O-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:anthocyanidin 3-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Anthocyanidin = UDP +
            Anthocyanidin-3-O-D-glucoside
SUBSTRATE   UDPglucose
            Anthocyanidin
PRODUCT     UDP
            Anthocyanidin-3-O-D-glucoside
COMMENT     Pelargonidin and delphinidin can also act as acceptors, more
            slowly. The enzyme does not catalyse glucosylation of the
            5-position of cyanidin and does not act on flavonos such as
            quercitin and kaempferol (cf. EC 2.4.1.91).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.115
            ExPASy - ENZYME nomenclature database: 2.4.1.115
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.115
            BRENDA, the Enzyme Database: 2.4.1.115
///
ENTRY       EC 2.4.1.116
NAME        Cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside
            $ 5-O-D-glucosyltransferase
REACTION    UDPglucose + Cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside = UDP +
            Cyanidin-3-O-[D-rhamnosyl-1,6-D-glucoside]-5-O-D-glucoside
SUBSTRATE   UDPglucose
            Cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside
PRODUCT     UDP
            Cyanidin-3-O-[D-rhamnosyl-1,6-D-glucoside]-5-O-D-glucoside
COMMENT     Pelargonidin-3-O-rhamnosyl glucoside, and, more slowly, cyanidin
            3-O-glucoside, can also act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.116
            ExPASy - ENZYME nomenclature database: 2.4.1.116
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.116
            BRENDA, the Enzyme Database: 2.4.1.116
///
ENTRY       EC 2.4.1.117
NAME        Dolichyl-phosphate beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase
REACTION    UDPglucose + Dolichyl phosphate = UDP +
            Dolichyl beta-D-glucosyl phosphate
SUBSTRATE   UDPglucose
            Dolichyl phosphate
PRODUCT     UDP
            Dolichyl beta-D-glucosyl phosphate
COMMENT     Solanesyl phosphate and ficaprenyl phosphate can act as acceptors,
            more slowly.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YPL227C(ALG5)
            SPO: SPBC56F2.10C(spbc56f2.10c)
            HSA: 29880(ALG5)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.117
            ExPASy - ENZYME nomenclature database: 2.4.1.117
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.117
            BRENDA, the Enzyme Database: 2.4.1.117
///
ENTRY       EC 2.4.1.118
NAME        Cytokinin 7-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:zeatin 7-glucosyltransferase
REACTION    UDPglucose + N6-Alkylaminopurine = UDP +
            N6-Alkylaminopurine-7-beta-D-glucoside
SUBSTRATE   UDPglucose
            N6-Alkylaminopurine
PRODUCT     UDP
            N6-Alkylaminopurine-7-beta-D-glucoside
COMMENT     Acts on a range of N6-substituted adenines, including zeatin
            (N6-(4-hydroxy-3-methylbut-trans-2-enylamino)purine) and
            N6-benzylaminopurine, but not N6-benzyladenine. With some
            acceptors, 9-beta-D-glucosides are also formed.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.118
            ExPASy - ENZYME nomenclature database: 2.4.1.118
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.118
            BRENDA, the Enzyme Database: 2.4.1.118
///
ENTRY       EC 2.4.1.119
NAME        Dolichyl-diphosphooligosaccharide--protein glycosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Dolichyl-diphosphooligosaccharide:protein-L-asparagine
            oligopolysaccharidotransferase
REACTION    Dolichyl diphosphooligosaccharide + Protein asparagine =
            Dolichyl diphosphate + a Glycoprotein with oligosaccharide chain
            $ attached by glycosylamine linkage to protein L-asparagine
SUBSTRATE   Dolichyl diphosphooligosaccharide
            Protein asparagine
PRODUCT     Dolichyl diphosphate
            N-Glycosyl-L-asparagine
COMMENT     Transfers the glucosyl-mannosyl-glucosamine polysaccharide
            side-chains of glycoproteins to an asparagine residue in the
            sequence Asn-Xaa-Ser or Asn-Xaa-Thr in the nascent polypeptide
            chains of the protein moiety.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YCL043C(PDI1) YDL232W(OST4) YEL002C(WBP1) YJL002C(OST1)
                 YML019W(OST6) YMR149W(SWP1) YOR085W(OST3) YOR103C(OST2)
            SPO: SPAC27F1.07(spac27f1.07) SPAC6F6.05(spac6f6.05)
                 SPCC338.15(spcc338.15)
            CEL: T09A5.11
            DME: CG9022(Ost48)
            HSA: 1650(DDOST) 6184(RPN1) 6185(RPN2)
DISEASE     MIM: 602202  Dolichyl-diphosphooligosaccharide-protein
                         glycosyltransferase
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00194  [LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-
                         C-[GATPLVE]-[PHYWSTA]-C-x(6)-[LIVMFYWT]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.119
            ExPASy - ENZYME nomenclature database: 2.4.1.119
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.119
            BRENDA, the Enzyme Database: 2.4.1.119
///
ENTRY       EC 2.4.1.120
NAME        Sinapate 1-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:sinapate D-glucosyltransferase
REACTION    UDPglucose + Sinapate = UDP + 1-Sinapoyl-D-glucose
SUBSTRATE   UDPglucose
            Sinapate
PRODUCT     UDP
            1-Sinapoyl-D-glucose
COMMENT     Some other hydroxycinnamates, including 4-coumarate, ferulate and
            caffeate, can act as acceptors, more slowly. Only glucose esters,
            not glucosides, are formed (cf. EC 2.4.1.126).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.120
            ExPASy - ENZYME nomenclature database: 2.4.1.120
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.120
            BRENDA, the Enzyme Database: 2.4.1.120
///
ENTRY       EC 2.4.1.121
NAME        Indole-3-acetate beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:indole-3-acetate beta-D-glucosyltransferase
REACTION    UDPglucose + Indole-3-acetate = UDP +
            Indole-3-acetyl-beta-1-D-glucose
SUBSTRATE   UDPglucose
            Indole-3-acetate
PRODUCT     UDP
            Indole-3-acetyl-beta-1-D-glucose
MOTIF       PS: PS00375  [FW]-x(2)-Q-x(2)-[LIVMYA]-[LIMV]-x(4,6)-[LVGAC]-
                         [LVFYA]-[LIVMF]-[STAGCM]-[HNQ]-[STAGC]-G-x(2)-[STAG]-
                         x(3)-[STAGL]-[LIVMFA]-x(4)-[PQR]-[LIVMT]-x(3)-[PA]-
                         x(3)-[DES]-[QEHN]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.121
            ExPASy - ENZYME nomenclature database: 2.4.1.121
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.121
            BRENDA, the Enzyme Database: 2.4.1.121
///
ENTRY       EC 2.4.1.122
NAME        Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:glycoprotein-N-acetyl-D-galactosamine
            $ 3-beta-D-galactosyltransferase
REACTION    UDPgalactose + Glycoprotein N-acetyl-D-galactosamine = UDP +
            Glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
SUBSTRATE   UDPgalactose
            Glycoprotein N-acetyl-D-galactosamine
PRODUCT     UDP
            Glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
COMMENT     The non-reducing O-serine-linked N-acetylgalactosamine residues in
            mucin glycoprotein can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.122
            ExPASy - ENZYME nomenclature database: 2.4.1.122
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.122
            BRENDA, the Enzyme Database: 2.4.1.122
///
ENTRY       EC 2.4.1.123
NAME        Inositol 1-alpha-galactosyltransferase
            Galactinol synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase
REACTION    UDPgalactose + myo-Inositol = UDP +
            1-O-alpha-D-Galactosyl-D-myo-inositol
SUBSTRATE   UDPgalactose
            myo-Inositol
PRODUCT     UDP
            1-O-alpha-D-Galactosyl-D-myo-inositol
COMMENT     An enzyme from cucurbits involved in the formation of raffinose
            and stachyose (cf. EC 2.4.1.67 and 2.4.1.82).
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.123
            ExPASy - ENZYME nomenclature database: 2.4.1.123
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.123
            BRENDA, the Enzyme Database: 2.4.1.123
///
ENTRY       EC 2.4.1.124
NAME        N-Acetyllactosamine 3-alpha-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine
            3-alpha-D-galactosyltransferase
REACTION    UDPgalactose + beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine = UDP
            + alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-
            $glucosamine
SUBSTRATE   UDPgalactose
            beta-D-Galactosyl-1,4-N-acetyl-D-glucosamine
            N-Acetyllactosamine
PRODUCT     UDP
            alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-
            $glucosamine
            alpha-D-Galactosyl-N-acetyllactosamine
COMMENT     The non-reducing terminal N-acetyllactosamine residues of
            glycoproteins can also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.124
            ExPASy - ENZYME nomenclature database: 2.4.1.124
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.124
            BRENDA, the Enzyme Database: 2.4.1.124
///
ENTRY       EC 2.4.1.125
NAME        Sucrose--1,6-alpha-glucan 3(6)-alpha-glucosyltransferase
            Water-soluble-glucan synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase
REACTION    Sucrose + (1,6-alpha-D-Glucosyl)n = D-Fructose +
            (1,6-alpha-D-Glucosyl)n+1
SUBSTRATE   Sucrose
            (1,6-alpha-D-Glucosyl)n
PRODUCT     D-Fructose
            (1,6-alpha-D-Glucosyl)n
COMMENT     Also transfers glucosyl residues to the 3-position on glucose
            residues in glucans, producing a highly-branched
            1,6-alpha-D-glucan.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.125
            ExPASy - ENZYME nomenclature database: 2.4.1.125
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.125
            BRENDA, the Enzyme Database: 2.4.1.125
///
ENTRY       EC 2.4.1.126
NAME        Hydroxycinnamate 4-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase
REACTION    UDPglucose + trans-4-Hydroxycinnamate = UDP +
            4-O-beta-D-Glucosyl-4-hydroxycinnamate
SUBSTRATE   UDPglucose
            trans-4-Hydroxycinnamate
            4-Coumarate
            Ferulate
            Caffeate
            Sinapate
PRODUCT     UDP
            4-O-beta-D-Glucosyl-4-hydroxycinnamate
COMMENT     Acts on 4-coumarate, ferulate, caffeate and sinapate, forming a
            mixture of 4-glucosides and glucose esters (cf. EC 2.4.1.120).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.126
            ExPASy - ENZYME nomenclature database: 2.4.1.126
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.126
            BRENDA, the Enzyme Database: 2.4.1.126
///
ENTRY       EC 2.4.1.127
NAME        Monoterpenol beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:(-)-menthol O-beta-D-glucosyltransferase
REACTION    UDPglucose + (-)-Menthol = UDP + (-)-Menthyl O-beta-D-glucoside
SUBSTRATE   UDPglucose
            (-)-Menthol
            (+)-Neomenthol
PRODUCT     UDP
            (-)-Menthyl O-beta-D-glucoside
            (+)-Neomenthyl O-beta-D-glucoside
COMMENT     (+)-Neomenthol can also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.127
            ExPASy - ENZYME nomenclature database: 2.4.1.127
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.127
            BRENDA, the Enzyme Database: 2.4.1.127
///
ENTRY       EC 2.4.1.128
NAME        Scopoletin glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:scopoletin O-beta-D-glucosyltransferase
REACTION    UDPglucose + Scopoletin = UDP + Scopolin
SUBSTRATE   UDPglucose
            Scopoletin
PRODUCT     UDP
            Scopolin
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.128
            ExPASy - ENZYME nomenclature database: 2.4.1.128
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.128
            BRENDA, the Enzyme Database: 2.4.1.128
///
ENTRY       EC 2.4.1.129
NAME        Peptidoglycan glycosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Bactoprenyldiphospho-N-acetylmuranoyl-(N-acetyl-D-glucosaminyl)-
            $pentapeptide:peptidoglycan N-acetylmuranoyl-N-acetyl-
            $D-glucosaminyltransferase
REACTION    n Bactoprenyldiphospho-N-acetylmuranoyl-(N-acetyl-D-glucosaminyl)-
            $L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanyl-D-alanine = 
            a Polymer with n linked disaccharide subunits
SUBSTRATE   Bactoprenyldiphospho-N-acetylmuranoyl-(N-acetyl-D-glucosaminyl)-
            $L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanyl-D-alanine
PRODUCT     Polymer with n linked disaccharide subunits
COMMENT     Involved in the synthesis of cell-wall peptidoglycan.
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.129
            ExPASy - ENZYME nomenclature database: 2.4.1.129
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.129
            BRENDA, the Enzyme Database: 2.4.1.129
///
ENTRY       EC 2.4.1.130
NAME        Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Dolichyl-phosphate-D-mannose:glycolipid alpha-D-
            $mannosyltransferase
REACTION    Transfers an alpha-D-mannosyl residue from dolichyl-phosphate
            D-mannose into membrane lipid-linked oligosaccharide
SUBSTRATE   Dolichyl phosphate D-mannose
            Lipid-linked oligosaccharide
PRODUCT     Dolichyl phosphate
            Lipid-linked oligosaccharide
COMMENT     Four of the nine mannosyl residues in the main membrane lipid-
            -linked oligosaccharide of the structure Glc3Man9GlcNAc2 are
            produced by the action of this enzyme.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.130
            ExPASy - ENZYME nomenclature database: 2.4.1.130
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.130
            BRENDA, the Enzyme Database: 2.4.1.130
///
ENTRY       EC 2.4.1.131
NAME        Glycolipid 2-alpha-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:glycolipid 1,2-alpha-D-mannosyltransferase
REACTION    Transfers an alpha-D-mannosyl residue from GDPmannose into lipid-
            -linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose
            linkage
SUBSTRATE   GDPmannose
            Lipid-linked oligosaccharide
PRODUCT     GDP
            Lipid-linked oligosaccharide
COMMENT     The two 1,2-linked mannosyl residues in the mammalian lipid-linked
            oligosaccharide of the structure Glc3Man9GlcNAc2 are produced by
            the action of this enzyme.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YBR199W(KTR4) YBR205W(KTR3) YDR483W(KRE2) YIL085C(KTR7)
                 YJL139C(YUR1) YKR061W(KTR2) YNL029C(KTR5) YOR099W(KTR1)
                 YPL053C(KTR6)
            SPO: SPBC19C7.12C(spbc19c7.12c)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.131
            ExPASy - ENZYME nomenclature database: 2.4.1.131
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.131
            BRENDA, the Enzyme Database: 2.4.1.131
///
ENTRY       EC 2.4.1.132
NAME        Glycolipid 3-alpha-mannosyltransferase
            Mannosyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:glycolipid 1,3-alpha-D-mannosyltransferase
REACTION    Transfers an alpha-D-mannosyl residue from GDPmannose into lipid-
            -linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-
            mannose linkage.
SUBSTRATE   GDPmannose
            Lipid-linked oligosaccharide
PRODUCT     GDP
            Lipid-linked oligosaccharide
COMMENT     The 1,3-linked mannosyl residue in the mammalian lipid-linked
            oligosaccharide of the structure Glc3Man9GlcNAc2 is produced by this
            enzyme.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.132
            ExPASy - ENZYME nomenclature database: 2.4.1.132
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.132
            BRENDA, the Enzyme Database: 2.4.1.132
///
ENTRY       EC 2.4.1.133
NAME        Xylosylprotein 4-beta-galactosyltransferase
            Galactosyltransferase I
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-
            $galactosyltransferase
REACTION    UDPgalactose + O-beta-D-Xylosylprotein = UDP +
            4-beta-D-Galactosyl-O-beta-D-xylosylprotein
SUBSTRATE   UDPgalactose
            O-beta-D-Xylosylprotein
PRODUCT     UDP
            4-beta-D-Galactosyl-O-beta-D-xylosylprotein
COFACTOR    Manganese
COMMENT     This enzyme is involved in the biosynthesis of the linkage region
            of proteochondroitin sulfate. Requires Mn2+.
GENES       HSA: 11285(B4GALT7)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.133
            ExPASy - ENZYME nomenclature database: 2.4.1.133
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.133
            BRENDA, the Enzyme Database: 2.4.1.133
///
ENTRY       EC 2.4.1.134
NAME        Galactosylxylosylprotein 3-beta-galactosyltransferase
            Galactosyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein
            $3-beta-D-galactosyltransferase
REACTION    UDPgalactose + 4-beta-D-Galactosyl-O-beta-D-xylosylprotein = UDP +
            3-beta-D-Galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
SUBSTRATE   UDPgalactose
            4-beta-D-Galactosyl-O-beta-D-xylosylprotein
PRODUCT     UDP
            3-beta-D-Galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
COFACTOR    Manganese
COMMENT     This enzyme is involved in the biosynthesis of the linkage region
            of proteochondroitin sulfate. Requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.134
            ExPASy - ENZYME nomenclature database: 2.4.1.134
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.134
            BRENDA, the Enzyme Database: 2.4.1.134
///
ENTRY       EC 2.4.1.135
NAME        Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
            Glucuronosyltransferase I
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-
            $xylosylprotein D-glucuronosyltransferase
REACTION    UDPglucuronate + 3-beta-D-Galactosyl-4-beta-D-galactosyl-
            $O-beta-D-xylosylprotein = UDP + 3-beta-D-Glucuronosyl-3-beta-D-
            $galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
SUBSTRATE   UDPglucuronate
            3-beta-D-Galactosyl-4-D-galactosyl-O-beta-D-xylosylprotein
PRODUCT     UDP
            3-beta-D-Glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-
            $beta-D-xylosylprotein
COFACTOR    Manganese
COMMENT     This enzyme is involved in the biosynthesis of the heparin-
            -polypeptide linkage region and of proteochondroitin sulfate
            linkage region. Requires Mn2+.
GENES       CEL: ZK1307.5
            HSA: 26229(B3GAT3) 27087(B3GAT1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.135
            ExPASy - ENZYME nomenclature database: 2.4.1.135
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.135
            BRENDA, the Enzyme Database: 2.4.1.135
///
ENTRY       EC 2.4.1.136
NAME        Gallate 1-beta-glucosyltransferase
            UDPglucose--vanillate 1-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:gallate beta-D-glucosyltransferase
REACTION    UDPglucose + Gallate = UDP + 1-Galloyl-beta-glucose
SUBSTRATE   UDPglucose
            Gallaete
PRODUCT     UDP
            1-Galloyl-beta-glucose
COMMENT     A number of substitute benzoic acids, and, more slowly, cinnamic
            acids, can act as acceptors.  Vanilln is the best accprot
            investigates.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.136
            ExPASy - ENZYME nomenclature database: 2.4.1.136
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.136
            BRENDA, the Enzyme Database: 2.4.1.136
///
ENTRY       EC 2.4.1.137
NAME        sn-Glycerol-3-phosphate 2-alpha-galactosyltransferase
            Floridoside-phosphate synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-
            $galactosyltransferase
REACTION    UDPgalactose + sn-Glycerol 3-phosphate = UDP +
            2-(alpha-D-Galactosyl)-sn-glycerol 3-phosphate
SUBSTRATE   UDPgalactose
            sn-Glycerol 3-phosphate
PRODUCT     UDP
            2-(alpha-D-Galactosyl)-sn-glycerol 3-phosphate
COMMENT     The product is hydrolysed by a phosphatase to floridoside (cf.
            EC 2.4.1.96).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.137
            ExPASy - ENZYME nomenclature database: 2.4.1.137
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.137
            BRENDA, the Enzyme Database: 2.4.1.137
///
ENTRY       EC 2.4.1.138
NAME        Mannotetraose 2-alpha-N-acetylglucosaminyltransferase
            alpha-N-Acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-
            $D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            1,3-alpha-D-Mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-
            $D-mannose = UDP +
            1,3-alpha-D-Mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-
            $mannosyl)-1,2-alpha-D-mannosyl-D-mannose
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            1,3-alpha-D-Mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-
            $D-mannose
PRODUCT     UDP
            1,3-alpha-D-Mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-
            $mannosyl)-1,2-alpha-D-mannosyl-D-mannose
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.138
            ExPASy - ENZYME nomenclature database: 2.4.1.138
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.138
            BRENDA, the Enzyme Database: 2.4.1.138
///
ENTRY       EC 2.4.1.139
NAME        Maltose synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     alpha-D-Glucose-1-phosphate:alpha-D-glucose-1-phosphate
            $ 4-alpha-D-glucosyltransferase (dephosphorylating)
REACTION    alpha-D-Glucose 1-phosphate + alpha-D-Glucose 1-phosphate =
            Maltose + 2 Orthophosphate
SUBSTRATE   alpha-D-Glucose 1-phosphate
PRODUCT     Maltose
            Orthophosphate
COMMENT     Neither ferr orthophosphate nor maltose 1-phosphate is an
            intermediate in the reaction.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.139
            ExPASy - ENZYME nomenclature database: 2.4.1.139
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.139
            BRENDA, the Enzyme Database: 2.4.1.139
///
ENTRY       EC 2.4.1.140
NAME        Alternansucrase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase
REACTION    Transfers an alpha-D-glucosyl reside alternately to the
            6-position and the 3-position of the non-reducing terminal
            residue of an alpha-D-glucan, thus producing a glucan having
            alternating alpha-1,6- and alpha-1,3-linkages
SUBSTRATE   alpha-D-Glucan
PRODUCT     alpha-D-Glucan
COMMENT     The product which has quite different properties from other
            dextrans, has been called alternan.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.140
            ExPASy - ENZYME nomenclature database: 2.4.1.140
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.140
            BRENDA, the Enzyme Database: 2.4.1.140
///
ENTRY       EC 2.4.1.141
NAME        N-Acetylglucosaminyldiphosphodolichol
            $ N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl
            $diphosphodolichol N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            N-Acetyl-D-glucosaminyldiphosphodolichol = UDP +
            N,N'-Diacetylchitobiosyldiphosphodolichol
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            N-Acetyl-D-glucosaminyldiphosphodolichol
PRODUCT     UDP
            N,N'-Diacetylchitobiosyldiphosphodolichol
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.141
            ExPASy - ENZYME nomenclature database: 2.4.1.141
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.141
            BRENDA, the Enzyme Database: 2.4.1.141
///
ENTRY       EC 2.4.1.142
NAME        Chitobiosyldiphosphodolichol alpha-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDPmannose:chitobiosyldiphosphodolichol alpha-D-
            $mannosyltransferase
REACTION    GDPmannose + Chitobiosyldiphosphodolichol = GDP +
            alpha-D-Mannosylchitobiosyldiphosphodolichol
SUBSTRATE   GDPmannose
            Chitobiosyldiphosphodolichol
PRODUCT     GDP
            alpha-D-Mannosylchitobiosyldiphosphodolichol
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.142
            ExPASy - ENZYME nomenclature database: 2.4.1.142
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.142
            BRENDA, the Enzyme Database: 2.4.1.142
///
ENTRY       EC 2.4.1.143
NAME        alpha-1,6-Mannosyl-glycoprotein beta-1,2-N-
            $acetylglucosaminyltransferase
            N-Glycosyl-oligosaccharide-glycoprotein N-
            $acetylglucosaminyltransferase II
            N-Acetylglucosaminyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine
            $ to alpha-D-mannosyl-1,6-(R1)-beta-D-mannosyl-R2) beta-1,2-N-
            $acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + alpha-D-Mannosyl-1,6-(N-acetyl-
            $beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-
            $mannosyl-R = UDP + N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,3)-beta-D-mannosyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            alpha-D-Mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,3)-beta-D-mannosyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-
            $beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R
COMMENT     The only known acceptor for this enzyme is the structure shown
            under 'reaction'. R represents the remainder of the
            N-oligosaccharide core (+/- fucose). cf. EC 2.4.1.101, 2.4.1.144,
            2.4.1.145, 2.4.1.155 and 2.4.1.201.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       MTH: MTH331
            HSA: 4247(MGAT2)
DISEASE     MIM: 602616  mannosyl (alpha-1,6-)-glycoprotein
                         beta-1,2-N-acetylglucosaminyl-
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.143
            ExPASy - ENZYME nomenclature database: 2.4.1.143
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.143
            BRENDA, the Enzyme Database: 2.4.1.143
///
ENTRY       EC 2.4.1.144
NAME        beta-1,4-Mannosyl-glycoprotein beta-1,4-N-acetyl-
            $glucosaminyltransferase
            N-Glycosyl-oligosaccharide-glycoprotein
            $ N-acetylglucosaminyltransferase III
            N-Acetylglucosaminyltransferase III
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-
            $glucosamine to beta-D-mannosyl of R1(R2)-beta-D-mannosyl-1,4-
            $N-acetyl-beta-D-glucosaminyl-R3) beta-1,4-N-acetyl-D-
            $glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            (N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-
            $(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-
            $1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R =
            UDP +
            N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-
            $beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-
            $glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-
            $glucosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            (N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-
            $(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-
            $1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-
            $beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-
            $glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-
            $glucosaminyl-R
COMMENT     The only known acceptor for this enzyme is the structure shown
            under 'reaction'. R represents the remainder of the
            N-oligosaccharide core (+/- fucose). cf. EC 2.4.1.101, 2.4.1.143,
            2.4.1.145, 2.4.1.155 and 2.4.1.201.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       MMU: 104532(Mgat3)
            HSA: 4248(MGAT3)
DISEASE     MIM: 604621  Beta-1,4-mannosyl-glycoprotein
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.144
            ExPASy - ENZYME nomenclature database: 2.4.1.144
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.144
            BRENDA, the Enzyme Database: 2.4.1.144
///
ENTRY       EC 2.4.1.145
NAME        alpha-1,3-Mannosylglycoprotein beta-1,4-N-acetylglucosaminyl
            $transferase
            N-Glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyl
            $transferase IV
            N-Acetylglucosaminyltransferase IV
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine
            to alpha-D-mannosyl-1,3- of R1-alpha-D-mannosyl-1,3-(R2)-beta-D-
            $mannosyl-R3)-beta-1,4-N-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + (N-Acetyl-beta-D-glucosaminyl-1,2)-
            $alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-
            $mannosyl-1,6)-beta-D-mannosyl-R =
            UDP + N-Acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-beta-D-glucos
            $aminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-
            $1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            (N-Acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-
            $acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-
            $mannosyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-beta-D-glucosaminyl-
            $1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-
            $alpha-D-mannosyl-1,6)-beta-D-mannosyl-R
COMMENT     The only known acceptor for this enzyme is the structure shown
            under 'reaction'. R represents the remainder of the N-oligo-
            saccharide core (+/- fucose) (cf. EC 2.4.1.101, 2.4.1.143,
            2.4.1.145 and 2.4.1.155).
GENES       HSA: 11282(MGAT4B) 11320(MGAT4A)
DISEASE     MIM: 604561  Alpha-1,3-mannosyl-glycoprotein
            MIM: 604623  Alpha-1,3-mannosyl-glycoprotein
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.145
            ExPASy - ENZYME nomenclature database: 2.4.1.145
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.145
            BRENDA, the Enzyme Database: 2.4.1.145
///
ENTRY       EC 2.4.1.146
NAME        beta-1,3-Galactosyl-O-glycosyl-glycoprotein beta-1,3-N-
            $acetylglucosaminyltransferase
            O-Glycosyl-oligosaccharide-glycoprotein N-
            $acetylglucosaminyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-
            $D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-
            $acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R)
            $ beta-1,3-N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + beta-D-Galactosyl-1,3-(N-acetyl-
            $D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R = UDP + N-Acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-
            $beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            beta-D-Galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-
            $galactosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-
            $beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R
COMMENT     cf. EC 2.4.1.102, 2.4.1.147 and 2.4.1.148.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.146
            ExPASy - ENZYME nomenclature database: 2.4.1.146
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.146
            BRENDA, the Enzyme Database: 2.4.1.146
///
ENTRY       EC 2.4.1.147
NAME        Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-
            $acetylglucosaminyltransferase
            O-Glycosyl-oligosaccharide-glycoprotein N-
            $acetylglucosaminyltransferase III
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-
            $D-glucosamine to N-acetyl-D-galactosaminyl-R)
            $ beta-1,3-N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + N-Acetyl-beta-D-galactosaminyl-R =
            UDP + N-Acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            N-Acetyl-beta-D-galactosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
COMMENT     cf. EC 2.4.1.102, 2.4.1.146 and 2.4.1.148.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.147
            ExPASy - ENZYME nomenclature database: 2.4.1.147
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.147
            BRENDA, the Enzyme Database: 2.4.1.147
///
ENTRY       EC 2.4.1.148
NAME        Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-
            $acetylglucosaminyltransferase
            O-Glycosyl-oligosaccharide-glycoprotein N-
            $acetylglucosaminyltransferase IV
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein
            $ (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of
            $ N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R)
            $ beta-1,6-N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + N-Acetyl-beta-D-glucosaminyl-1,3-
            $N-acetyl-D-galactosaminyl-R = UDP + N-Acetyl-beta-D-
            $glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-
            $N-acetyl-D-galactosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            N-Acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-
            $1,3)-N-acetyl-D-galactosaminyl-R
COMMENT     cf. EC 2.4.1.102, 2.4.1.146 and 2.4.1.147.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.148
            ExPASy - ENZYME nomenclature database: 2.4.1.148
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.148
            BRENDA, the Enzyme Database: 2.4.1.148
///
ENTRY       EC 2.4.1.149
NAME        N-Acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-
            $D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + beta-D-Galactosyl-1,4-N-acetyl-
            $D-glucosaminyl-R = UDP + N-Acetyl-beta-D-glucosaminyl-1,3-
            $beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            beta-D-Galactosyl-1,4-N-acetyl-D-glucosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-
            $D-glucosaminyl-R
COMMENT     Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on
            asialo-alpha1-acid glycoprotein and other glycoproteins and
            oligosaccharicd.
PATHWAY     PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.149
            ExPASy - ENZYME nomenclature database: 2.4.1.149
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.149
            BRENDA, the Enzyme Database: 2.4.1.149
///
ENTRY       EC 2.4.1.150
NAME        N-Acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
            N-Acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-
            $D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + beta-D-Galactosyl-1,4-N-acetyl-
            $D-glucosaminyl-R = UDP + N-Acetyl-beta-D-glucosaminyl-1,6-
            $beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            beta-D-Galactosyl-1,4-N-acetyl-D-glucosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-
            $D-glucosaminyl-R
COMMENT     Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on
            asialo-alpha1-acid glycoprotein.
PATHWAY     PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 2651(GCNT2)
DISEASE     MIM: 600429  Glucosaminyl (N-acetyl) transferase 2, I-branching
                         enzyme
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.150
            ExPASy - ENZYME nomenclature database: 2.4.1.150
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.150
            BRENDA, the Enzyme Database: 2.4.1.150
///
ENTRY       EC 2.4.1.151
NAME        N-Acetyllactosaminide alpha-1,3-galactosyltransferase
            Galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide
            alpha-1,3-galactosyltransferase
REACTION    UDPgalactose + beta-D-Galactosyl-1,4-N-acetyl-D-glucosaminyl-R =
            UDP + alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-
            $D-glucosaminyl-R
SUBSTRATE   UDPgalactose
            beta-D-Galactosyl-1,4-N-acetyl-D-glucosaminyl-R
PRODUCT     UDP
            alpha-D-Galactosyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-
            $glucosaminyl-R
COMMENT     Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on
            asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-
            -D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on
            2'-fucosylated-N-acetyllactosamine.
GENES       AAE: aq_516(mtfC)
            AFU: AF1728
            MMU: 95704(Ggta1)
STRUCTURES  PDB: 1G93  1G8O  1FG5  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.151
            ExPASy - ENZYME nomenclature database: 2.4.1.151
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.151
            BRENDA, the Enzyme Database: 2.4.1.151
///
ENTRY       EC 2.4.1.152
NAME        Galactoside 3-fucosyltransferase
            Lewis-negative alpha-3-fucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
            3-L-fucosyltransferase
REACTION    GDP-L-fucose + 1,4-beta-Galactosyl-N-acetyl-D-glucosaminyl-R =
            GDP +
            1,4-beta-D-Galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-
            $glucosaminyl-R
SUBSTRATE   GDP-L-fucose
            1,4-beta-Galactosyl-N-acetyl-D-glucosaminyl-R
PRODUCT     GDP
            1,4-beta-D-Galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-
            $glucosaminyl-R
COMMENT     Unlike EC 2.4.1.65, has no action on the corresponding
            1,3-galactosyl derivative. cf. also EC 2.4.1.69.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.152
            ExPASy - ENZYME nomenclature database: 2.4.1.152
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.152
            BRENDA, the Enzyme Database: 2.4.1.152
///
ENTRY       EC 2.4.1.153
NAME        Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-
            $D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Dolichyl phosphate = UDP +
            Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Dolichyl phosphate
PRODUCT     UDP
            Dolichyl N-acetyl-alpha-D-glucosaminyl phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.153
            ExPASy - ENZYME nomenclature database: 2.4.1.153
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.153
            BRENDA, the Enzyme Database: 2.4.1.153
///
ENTRY       EC 2.4.1.154
NAME        Globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase
            Globoside N-acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine-globotriosylceramide
            $ beta-1,6-N-acetylgalactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine + Globotriosylceramide = UDP +
            Globotetraosylceramide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            Globotriosylceramide
PRODUCT     UDP
            Globotetraosylceramide
COMMENT     The enzyme is highly acceptor-specific; it does not act on
            globotetraosylceramide or lactosylceramide.  The product has a
            terminal beta-N-acetylgalactosamine residue.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.154
            ExPASy - ENZYME nomenclature database: 2.4.1.154
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.154
            BRENDA, the Enzyme Database: 2.4.1.154
///
ENTRY       EC 2.4.1.155
NAME        alpha-1,3(6)-Mannosylglycoprotein beta-1,6-N-
            $acetylglucosaminyltransferase
            alpha-Mannoside beta-1,6-N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine
            $ to alpha-D-mannosyl-1,3(6)-N-acetyl-beta-D-glucosaminyl-R)
            $ beta-1,6-N-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + N-Acetyl-beta-D-glucosaminyl-1,2-
            $alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-
            $alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-
            $glucosaminyl-R = UDP +
            N-Acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-
            $1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-
            $1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-
            $D-glucosaminyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-
            $acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-
            $D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-
            $1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-
            $1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-
            $D-glucosaminyl-R
COMMENT     Only branched mannose glycopeptides with non-reducing
            N-acetylglucosamine terminal residues act as acceptors (cf.
            EC 2.4.1.101, 2.4.1.143-5).
GENES       HSA: 4249(MGAT5)
DISEASE     MIM: 601774  Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.155
            ExPASy - ENZYME nomenclature database: 2.4.1.155
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.155
            BRENDA, the Enzyme Database: 2.4.1.155
///
ENTRY       EC 2.4.1.156
NAME        Indolylacetyl-myo-inositol galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:indol-3-ylacetyl-myo-inositol
            $ 5-O-D-galactosyltransferase
REACTION    UDPgalactose + Indol-3-ylacetyl-myo-inositol = UDP +
            5-O-(Indol-3-ylacetyl-myo-inositol) D-galactoside
SUBSTRATE   UDPgalactose
            Indol-3-ylacetyl-myo-inositol
PRODUCT     UDP
            5-O-(Indol-3-ylacetyl-myo-inositol) D-galactoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.156
            ExPASy - ENZYME nomenclature database: 2.4.1.156
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.156
            BRENDA, the Enzyme Database: 2.4.1.156
///
ENTRY       EC 2.4.1.157
NAME        1,2-Diacylglycerol 3-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase
REACTION    UDPglucose + 1,2-Diacylglycerol = UDP +
            3-D-Glucosyl-1,2-diacylglycerol
SUBSTRATE   UDPglucose
            1,2-Diacylglycerol
PRODUCT     UDP
            3-D-Glucosyl-1,2-diacylglycerol
COMMENT     Many diacylglycerols with long-chain acyl groups can act as
            acceptors.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.157
            ExPASy - ENZYME nomenclature database: 2.4.1.157
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.157
            BRENDA, the Enzyme Database: 2.4.1.157
///
ENTRY       EC 2.4.1.158
NAME        13-Hydroxydocosanoate 13-beta-glucosyltransferase
            13-Glucosyloxydocosanoate 2'-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase
REACTION    UDPglucose + 13-Hydroxydocosanoate = UDP +
            13-beta-D-Glucosyloxydocosanoate
SUBSTRATE   UDPglucose
            13-Hydroxydocosanoate
PRODUCT     UDP
            13-beta-D-Glucosyloxydocosanoate
COMMENT     13-beta-D-Glucosyloxydocosanoate can also act as acceptor,
            leading to the formation by Candida bogoriensis of the
            extracellular glycolipid, hydroxydocosanoate sophoroside
            diacetate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.158
            ExPASy - ENZYME nomenclature database: 2.4.1.158
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.158
            BRENDA, the Enzyme Database: 2.4.1.158
///
ENTRY       EC 2.4.1.159
NAME        Flavonol-3-O-glucoside L-rhamnosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-L-rhamnose:flavonol-3-O-D-glucoside L-rhamnosyltransferase
REACTION    UDP-L-rhamnose + Flavonol 3-O-D-glucoside = UDP +
            Flavonol 3-O-L-rhamnosylglucoside
SUBSTRATE   UDP-L-rhamnose
            Flavonol 3-O-D-glucoside
PRODUCT     UDP
            Flavonol 3-O-L-rhamnosylglucoside
COMMENT     Converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts,
            more slowly, on rutin, quercitin 3-O-galactoside and flavonol
            3-O-rhamnosides.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.159
            ExPASy - ENZYME nomenclature database: 2.4.1.159
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.159
            BRENDA, the Enzyme Database: 2.4.1.159
///
ENTRY       EC 2.4.1.160
NAME        Pyridoxine 5'-O-beta-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Pyridoxine = UDP + 5'-O-beta-D-Glucosylpyridoxine
SUBSTRATE   UDPglucose
            Pyridoxine
PRODUCT     UDP
            5'-O-beta-D-Glucosylpyridoxine
COMMENT     4'-Deoxypyridoxine and pyridoxamine can also act as acceptors,
            more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.160
            ExPASy - ENZYME nomenclature database: 2.4.1.160
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.160
            BRENDA, the Enzyme Database: 2.4.1.160
///
ENTRY       EC 2.4.1.161
NAME        Oligosaccharide 4-alpha-D-glucosyltransferase
            Amylase III
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-
            $glucosyltransferase
REACTION    transfers the non-reducing terminal alpha-D-glucose residue from
            a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan,
            thus bringing about the hydrolysis of oligosaccharides
SUBSTRATE   1,4-alpha-D-Glucan
            Amylose
            Amylopectin
            Glycogen
PRODUCT     1,4-alpha-D-Glucan
            Amylose
            Amylopectin
            Glycogen
COMMENT     Acts on amylose, amylopectin, glycogen and maltooligosaccharides,
            but not maltose. No detectable free glucose is formed.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.161
            ExPASy - ENZYME nomenclature database: 2.4.1.161
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.161
            BRENDA, the Enzyme Database: 2.4.1.161
///
ENTRY       EC 2.4.1.162
NAME        Aldose beta-fructosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     alpha-D-Aldosyl-beta-D-fructoside:aldose 1-beta-D-
            $fructosyltransferase
REACTION    alpha-D-Aldosyl1 beta-D-fructoside + D-Aldose2 = D-Aldose1 +
            alpha-D-Aldosyl2 beta-D-fructoside
SUBSTRATE   alpha-D-Aldosyl1 beta-D-fructoside
            D-Aldose1
PRODUCT     alpha-D-Aldosyl2 beta-D-fructoside
            D-Aldose2
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.162
            ExPASy - ENZYME nomenclature database: 2.4.1.162
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.162
            BRENDA, the Enzyme Database: 2.4.1.162
///
ENTRY       EC 2.4.1.163
NAME        beta-Galactosyl-N-acetylglucosaminylgalactosylglucosylceramide
            $ beta-1,3-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide beta-1,3-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + beta-D-Galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide = UDP +
            N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-
            $galactosyl-1,4-beta-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
COFACTOR    Manganese
COMMENT     Requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.163
            ExPASy - ENZYME nomenclature database: 2.4.1.163
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.163
            BRENDA, the Enzyme Database: 2.4.1.163
///
ENTRY       EC 2.4.1.164
NAME        Galactosyl-N-acetylglucosaminylgalactosyl-glucosylceramide
            $ beta-1,6-N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide beta-1,6-N-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + D-Galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide = UDP + N-Acetyl-D-glucosaminyl-
            $1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-
            $beta-D-galactosyl-1,4-beta-D-glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-
            $galactosyl-1,4-beta-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
COFACTOR    Manganese
COMMENT     Requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.164
            ExPASy - ENZYME nomenclature database: 2.4.1.164
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.164
            BRENDA, the Enzyme Database: 2.4.1.164
///
ENTRY       EC 2.4.1.165
NAME        N-Acetylneuraminylgalactosylglucosylceramide beta-1,4-N-
            $acetylgalactosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-Acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-
            $galactosyl1,4-beta-D-glucosylceramide beta-1,4-N-acetyl-
            $galactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine + N-Acetylneuraminyl-2,3-alpha-D-
            $galactosyl-1,4-beta-D-glucosylceramide = UDP + N-Acetyl-
            $D-galactosaminyl-1,4-beta-N-acetylneuraminyl-2,3-alpha-D-
            $galactosyl-1,4-beta-D-glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            N-Acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-
            $glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-1,4-beta-N-acetylneuraminyl-2,3-alpha-D-
            $galactosyl-1,4-beta-D-glucosylceramide
COFACTOR    Manganese
COMMENT     Requires Mn2+.  Only substances containing sialic acid residues
            can act as acceptors; bovine fetuin is the best acceptor tested.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.165
            ExPASy - ENZYME nomenclature database: 2.4.1.165
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.165
            BRENDA, the Enzyme Database: 2.4.1.165
///
ENTRY       EC 2.4.1.166
NAME        Raffinose--raffinose alpha-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Raffinose:raffinose alpha-D-galactosyltransferase
REACTION    2 Raffinose = 1F-alpha-D-Galactosylraffinose + Sucrose
SUBSTRATE   Raffinose
PRODUCT     1F-alpha-D-Galactosylraffinose
            Sucrose
            3F-alpha-D-Galactosylraffinose
COMMENT     The 3F position of raffinose can also act as galactosyl acceptor;
            the enzyme is involved in the accumulation of the tetrasaccharides
            lychnose and isolychnose in the leaves of Cerastium arvense and
            other plants of the family Caryophyllaceae during late autumn.
GENES       SPR: spr1223(cps23FU)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.166
            ExPASy - ENZYME nomenclature database: 2.4.1.166
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.166
            BRENDA, the Enzyme Database: 2.4.1.166
///
ENTRY       EC 2.4.1.167
NAME        Sucrose 6F-alpha-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase
REACTION    UDPgalactose + Sucrose = UDP + 6F-alpha-D-Galactosylsucrose
SUBSTRATE   UDPgalactose
            Sucrose
PRODUCT     UDP
            6F-alpha-D-Galactosylsucrose
COMMENT     The enzyme is involved in the synthesis of the trisaccharide
            planteose and higher analogues in the seeds of Plantago and
            Sesamum species.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.167
            ExPASy - ENZYME nomenclature database: 2.4.1.167
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.167
            BRENDA, the Enzyme Database: 2.4.1.167
///
ENTRY       EC 2.4.1.168
NAME        Xyloglucan 4-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase
REACTION    Transfers a beta-D-glucosyl residue from UDPglucose on to a
            glucose residue in xyloglucan, forming a
            beta-1,4-D-glucosyl-D-glucose linkage
SUBSTRATE   UDPglucose
            Xyloglucan
PRODUCT     UDP
            Xyloglucan
COMMENT     In association with EC 2.4.1.169, brings about the synthesis of
            xyloglucan; concurrent transfers of glucose and xylose are
            essential for this synthesis. Not identical with EC 2.4.1.12.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.168
            ExPASy - ENZYME nomenclature database: 2.4.1.168
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.168
            BRENDA, the Enzyme Database: 2.4.1.168
///
ENTRY       EC 2.4.1.169
NAME        Xyloglucan 6-xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase
REACTION    Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a
            glucose residue in xyloglucan, forming an
            alpha-1,6-D-xylosyl-D-glucose linkage
SUBSTRATE   UDP-D-xylose
            Xyloglucan
PRODUCT     UDP
            Xyloglucan
COMMENT     In association with EC 2.4.1.168, brings about the synthesis of
            xyloglucan; concurrent transfers of glucose and xylose are
            necessary for this synthesis.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.169
            ExPASy - ENZYME nomenclature database: 2.4.1.169
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.169
            BRENDA, the Enzyme Database: 2.4.1.169
///
ENTRY       EC 2.4.1.170
NAME        Isoflavone 7-O-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Isoflavone = UDP + Isoflavone 7-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            Isoflavone
PRODUCT     UDP
            Isoflavone 7-O-beta-D-glucoside
COMMENT     The 4'-methoxy isoflavones biochanin A and formononetin and , more
            slowly, the 4'-hydroxy isoflavones genistein and daidzein, can act
            as acceptors. The enzyme does not act on isoflavanones, flavones,
            flavanones, flavanols or coumarins.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.170
            ExPASy - ENZYME nomenclature database: 2.4.1.170
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.170
            BRENDA, the Enzyme Database: 2.4.1.170
///
ENTRY       EC 2.4.1.171
NAME        Methyl-ONN-azoxymethanol glucosyltransferase
            Cycasin synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase
REACTION    UDPglucose + Methylazoxymethanol = UDP + Cycasin
SUBSTRATE   UDPglucose
            Methylazoxymethanol
PRODUCT     UDP
            Cycasin
COMMENT     Brings about the biosynthesis of the toxic substance cycasin in
            the leaves of Japanese cycad, Cycas revoluta.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.171
            ExPASy - ENZYME nomenclature database: 2.4.1.171
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.171
            BRENDA, the Enzyme Database: 2.4.1.171
///
ENTRY       EC 2.4.1.172
NAME        Salicyl-alcohol glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:salicyl-alcohol beta-D-glucosyltransferase
REACTION    UDPglucose + Salicyl alcohol = UDP + Salicin
SUBSTRATE   UDPglucose
            Salicyl alcohol
PRODUCT     UDP
            Salicin
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.172
            ExPASy - ENZYME nomenclature database: 2.4.1.172
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.172
            BRENDA, the Enzyme Database: 2.4.1.172
///
ENTRY       EC 2.4.1.173
NAME        Sterol glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:sterol 3-O-beta-D-glucosyltransferase
REACTION    UDPglucose + a Sterol = UDP + a Sterol 3-beta-D-glucoside
SUBSTRATE   UDPglucose
            Sterol
PRODUCT     UDP
            Sterol 3-beta-D-glucoside
COMMENT     Not identical with EC 2.4.1.192 or 2.4.1.193.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.173
            ExPASy - ENZYME nomenclature database: 2.4.1.173
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.173
            BRENDA, the Enzyme Database: 2.4.1.173
///
ENTRY       EC 2.4.1.174
NAME        Glucuronylgalactosylproteoglycan beta-1,4-N-
            $acetylgalactosaminyltransferase
            N-Acetylgalactosaminyltransferase I
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl
            $proteoglycan beta-1,4-N-acetylgalactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine +
            beta-D-Glucuronyl-1,3-D-galactosylproteoglycan = UDP +
            N-Acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-
            $galactosylproteoglycan
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            beta-D-Glucuronyl-1,3-D-galactosylproteoglycan
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-
            $galactosylproteoglycan
COFACTOR    Manganese
COMMENT     Requires Mn2+. Involved in the biosynthesis of chondroitin
            sulfate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.174
            ExPASy - ENZYME nomenclature database: 2.4.1.174
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.174
            BRENDA, the Enzyme Database: 2.4.1.174
///
ENTRY       EC 2.4.1.175
NAME        Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
            $acetylgalactosaminyltransferase
            N-Acetylgalactosaminyltransferase II
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-
            $1,3-beta-D-galactosaminylproteoglycan
            $ beta-1,4-N-acetylgalactosaminyltransferase
REACTION    UDP-N-acetyl-D-galactosamine + D-Glucuronyl-N-acetyl-1,3-
            $beta-D-galactosaminylproteoglycan = UDP + N-Acetyl-D-
            $galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-
            $galactosaminylproteoglycan
SUBSTRATE   UDP-N-acetyl-D-galactosamine
            D-Glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan
PRODUCT     UDP
            N-Acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-
            $beta-D-galactosaminylproteoglycan
COMMENT     Involved in the biosynthesis of chondroitin sulfate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.175
            ExPASy - ENZYME nomenclature database: 2.4.1.175
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.175
            BRENDA, the Enzyme Database: 2.4.1.175
///
ENTRY       EC 2.4.1.176
NAME        Gibberellin beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase
REACTION    UDPglucose + Gibberellin = UDP + Gibberellin 2-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            Gibberellin
PRODUCT     UDP
            Gibberellin 2-O-beta-D-glucoside
COMMENT     Acts on the plant hormone gibberellin GA3 and related compounds.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.176
            ExPASy - ENZYME nomenclature database: 2.4.1.176
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.176
            BRENDA, the Enzyme Database: 2.4.1.176
///
ENTRY       EC 2.4.1.177
NAME        Cinnamate glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:trans-cinnamate beta-D-glucosyltransferase
REACTION    UDPglucose + trans-Cinnamate = UDP +
            trans-Cinnamoyl beta-D-glucoside
SUBSTRATE   UDPglucose
            trans-Cinnamate
PRODUCT     UDP
            trans-Cinnamoyl beta-D-glucoside
COMMENT     4-Coumarate, 2-coumarate, benzoate, feruloate and caffeate can
            also act as acceptors, more slowly. Involved in the biosynthesis
            of chlorogenic acid in the root of the sweet potato, Ipomoea
            batatas.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.177
            ExPASy - ENZYME nomenclature database: 2.4.1.177
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.177
            BRENDA, the Enzyme Database: 2.4.1.177
///
ENTRY       EC 2.4.1.178
NAME        Hydroxymandelonitrile glucosyltransferase
            Cyanohydrin glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:4-hydroxymandelonitrile glucosyltransferase
REACTION    UDPglucose + 4-Hydroxymandelonitrile = UDP + Taxiphyllin
SUBSTRATE   UDPglucose
            4-Hydroxymandelonitrile
            3,4-Dihydroxymandelonitrile
PRODUCT     UDP
            Taxiphyllin
            Dhurrin
COMMENT     3,4-Dihydroxymandelonitrile can also act as acceptor.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.178
            ExPASy - ENZYME nomenclature database: 2.4.1.178
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.178
            BRENDA, the Enzyme Database: 2.4.1.178
///
ENTRY       EC 2.4.1.179
NAME        Lactosylceramide beta-1,3-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R
            $ beta-1,3-galactosyltransferase
REACTION    UDPgalactose + D-Galactosyl-1,4-beta-D-glucosyl-R = UDP +
            D-Galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R
SUBSTRATE   UDPgalactose
            D-Galactosyl-1,4-beta-D-glucosyl-R
PRODUCT     UDP
            D-Galactosyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyl-R
COMMENT     R may be an oligosaccharide or a glycolipid; lactose can also act
            as acceptor, more slowly. Involved in the elongation of
            oligosaccharide chains, especially in glycolipids.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.179
            ExPASy - ENZYME nomenclature database: 2.4.1.179
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.179
            BRENDA, the Enzyme Database: 2.4.1.179
///
ENTRY       EC 2.4.1.180
NAME        Lipopolysaccharide N-acetylmannosaminouronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide
            $ N-acetyl-beta-D-mannosaminouronoyltransferase
REACTION    UDP-N-acetyl-beta-D-mannosaminouronate + Lipopolysaccharide =
            UDP + N-Acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide
SUBSTRATE   UDP-N-acetyl-beta-D-mannosaminouronate
            Lipopolysaccharide
PRODUCT     UDP
            N-Acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide
COMMENT     Involved in the biosynthesis of common antigen in
            Enterobacteriaceae.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.180
            ExPASy - ENZYME nomenclature database: 2.4.1.180
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.180
            BRENDA, the Enzyme Database: 2.4.1.180
///
ENTRY       EC 2.4.1.181
NAME        Hydroxyanthraquinone glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:hydroxyanthraquinone O-glucosyltransferase
REACTION    UDPglucose + a Hydroxyanthraquinone = UDP +
            a Glucosyloxyanthraquinone
SUBSTRATE   UDPglucose
            Hydroxyanthraquinone
PRODUCT     UDP
            Glucosyloxyanthraquinone
COMMENT     A range of anthraquinones and same flavones can act as acceptors;
            best substrates are meodin, anthrapurpurin, quinizarin,
            2,6-dihydroanthraquinone and 1,8-dihydroxyanthraquinone.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.181
            ExPASy - ENZYME nomenclature database: 2.4.1.181
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.181
            BRENDA, the Enzyme Database: 2.4.1.181
///
ENTRY       EC 2.4.1.182
NAME        Lipid-A-disaccharide synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosamine:2,3-bis-
            $(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate
REACTION    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine +
            2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate =
            UDP +
            2,3-Bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-
            $bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
SUBSTRATE   UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
            2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
PRODUCT     UDP
            2,3-Bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-
            $bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
COMMENT     Involved with EC 2.3.1.129 and 2.7.1.130 in the biosynthesis of
            the phosphorylated glycolipid, Lipid A, in the outer membrane of
            Escherichia coli.
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b0182(lpxB)
            ECE: Z0194(lpxB)
            ECS: ECs0184
            YPE: YPO1057(lpxB)
            HIN: HI1060(lpxB)
            PMU: PM1997(lpxB)
            XFA: XF1042
            VCH: VC2247
            PAE: PA3643(lpxB)
            NME: NMB0199
            NMA: NMA0069(lpxB)
            HPY: HP0867(lpxB)
            HPJ: jhp0801
            CJE: Cj0288c(lpxB)
            RPR: RP321(lpxB)
            RCO: RC0440(lpxB)
            MLO: mll0630
            SME: SMc02089(lpxB)
            CCR: CC1909
            CTR: CT411
            CMU: TC0692
            CPN: CPn0965
            CPA: CP0895
            CPJ: lpxB
            SYN: slr0015(lpxB)
            AAE: aq_1427(lpxB)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.182
            ExPASy - ENZYME nomenclature database: 2.4.1.182
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.182
            BRENDA, the Enzyme Database: 2.4.1.182
///
ENTRY       EC 2.4.1.183
NAME        alpha-1,3-Glucan synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:alpha-D-(1,3)-glucan 3-alpha-D-glucosyltransferase
REACTION    UDPglucose + [alpha-D-Glucosyl-(1,3)]n = UDP +
            [alpha-D-Glucosyl-(1,3)]n+1
SUBSTRATE   UDPglucose
            [alpha-D-Glucosyl-(1,3)]n
PRODUCT     UDP
            [alpha-D-Glucosyl-(1,3)]n+1
COMMENT     A glucan primer is needed to begin the reaction, which brings
            about elongation of the glucan chains.
GENES       SPO: SPAC23D3.15
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.183
            ExPASy - ENZYME nomenclature database: 2.4.1.183
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.183
            BRENDA, the Enzyme Database: 2.4.1.183
///
ENTRY       EC 2.4.1.184
NAME        Galactolipid galactosyltransferase
            Galactolipid:galactolipid galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacyl
            $glycerol beta-D-galactosyltransferase
REACTION    2 Mono-beta-D-galactosyldiacylglycerol =
            alpha-D-Galactosyl-beta-D-galactosyldiacylglycerol +
            Diacylglycerol
SUBSTRATE   Mono-beta-D-galactosyldiacylglycerol
PRODUCT     alpha-D-Galactosyl-beta-D-galactosyldiacylglycerol
            Diacylglycerol
COMMENT     By further transfers of galactosyl residues to the
            digalactosyldiacylglycerol, trigalactosyldiacylglycerol and
            tetragalactosyldiacylglycerol are also formed.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.184
            ExPASy - ENZYME nomenclature database: 2.4.1.184
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.184
            BRENDA, the Enzyme Database: 2.4.1.184
///
ENTRY       EC 2.4.1.185
NAME        Flavanone 7-O-beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:flavanone 7-O-beta-D-glucosyltransferase
REACTION    UDPglucose + a Flavanone = UDP + a Flavanone 7-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            Flavanone
            Naringenin
            Hesperetin
PRODUCT     UDP
            Flavanone 7-O-beta-D-glucoside
COMMENT     Naringenin and hesperetin can act as acceptors. No action on
            flavone or flavonols.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.185
            ExPASy - ENZYME nomenclature database: 2.4.1.185
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.185
            BRENDA, the Enzyme Database: 2.4.1.185
///
ENTRY       EC 2.4.1.186
NAME        Glycogenin glucosyltransferase
            Glycogenin
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:glycogenin glucosyltransferase
REACTION    UDPglucose + Glycogenin = UDP + Glucosylglycogenin
SUBSTRATE   UDPglucose
            Glycogenin
PRODUCT     UDP
            Glucosylglycogenin
COMMENT     The glycogenin sub-unit of glycogen synthase (EC 2.4.1.11)
            catalyses this reaction, i.e. the enzyme catalyses its own
            autoglucosylation. Five molecules of glucose can be transferred to
            one molecule of glycogenin. The product acts as a primer for the
            reaction catalysed by glycogen synthase.
GENES       HSA: 2992(GYG) 8908(GYG2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.186
            ExPASy - ENZYME nomenclature database: 2.4.1.186
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.186
            BRENDA, the Enzyme Database: 2.4.1.186
///
ENTRY       EC 2.4.1.187
NAME        N-Acetylglucosaminyldiphosphoundecaprenol
            $ N-acetyl-beta-D-mannosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphospho
            $undecaprenol beta-1,4-N-acetylmannosaminyltransferase
REACTION    UDP-N-acetyl-D-mannosamine + N-Acetyl-D-glucosaminyldiphospho
            $undecaprenol = UDP + N-Acetyl-beta-D-mannosaminyl-
            $1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol
SUBSTRATE   UDP-N-acetyl-D-mannosamine
            N-Acetyl-D-glucosaminyldiphosphoundecaprenol
PRODUCT     UDP
            N-Acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyl
            $diphosphoundecaprenol
COMMENT     Involved in the biosynthesis of teichoic acid linkage units in
            bacterial cell walls.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.187
            ExPASy - ENZYME nomenclature database: 2.4.1.187
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.187
            BRENDA, the Enzyme Database: 2.4.1.187
///
ENTRY       EC 2.4.1.188
NAME        N-Acetylglucosaminyldiphosphoundecaprenol glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol
            $ 4-beta-D-glucosyltransferase
REACTION    UDPglucose + N-Acetyl-D-glucosaminyldiphosphoundecaprenol = UDP +
            beta-D-Glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol
SUBSTRATE   UDPglucose
            N-Acetyl-D-glucosaminyldiphosphoundecaprenol
PRODUCT     UDP
            beta-D-Glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.188
            ExPASy - ENZYME nomenclature database: 2.4.1.188
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.188
            BRENDA, the Enzyme Database: 2.4.1.188
///
ENTRY       EC 2.4.1.189
NAME        Luteolin 7-O-glucoronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate:luteolin 7-O-glucuronosyltransferase
REACTION    UDPglucuronate + Luteolin = UDP + Luteolin 7-O-beta-D-Glucuronide
SUBSTRATE   UDPglucuronate
            Luteolin
PRODUCT     UDP
            Luteolin 7-O-beta-D-Glucuronide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.189
            ExPASy - ENZYME nomenclature database: 2.4.1.189
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.189
            BRENDA, the Enzyme Database: 2.4.1.189
///
ENTRY       EC 2.4.1.190
NAME        Luteolin-7-O-glucuronide 7-O-glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate:luteolin-7-O-beta-D-glucuronide
            $ 7-O-glucuronosyltransferase
REACTION    UDPglucuronate + Luteolin 7-O-glucuronide = UDP +
            Luteolin 7-O-beta-D-diglucuronide
SUBSTRATE   UDPglucuronate
            Luteolin 7-O-glucuronide
PRODUCT     UDP
            Luteolin 7-O-beta-D-diglucuronide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.190
            ExPASy - ENZYME nomenclature database: 2.4.1.190
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.190
            BRENDA, the Enzyme Database: 2.4.1.190
///
ENTRY       EC 2.4.1.191
NAME        Luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucuronate:luteolin-7-O-beta-D-diglucuronide
            $ 4'-O-glucuronosyltransferase
REACTION    UDPglucuronate + Luteolin 7-O-beta-D-diglucuronide = UDP +
            Luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-
            $4'-O-beta-D-glucuronide
SUBSTRATE   UDPglucuronate
            Luteolin 7-O-beta-D-diglucuronide
PRODUCT     UDP
            Luteolin 7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]-
            $4'-O-beta-D-glucuronide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.191
            ExPASy - ENZYME nomenclature database: 2.4.1.191
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.191
            BRENDA, the Enzyme Database: 2.4.1.191
///
ENTRY       EC 2.4.1.192
NAME        Nuatigenin 3beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol
            $ 3-O-beta-D-glucosyltransferase
REACTION    UDPglucose +
            (20S,22S,25S)-22,25-Epoxyfurost-5-ene-3beta,26-diol =
            UDP + (20S,22S,25S)-22,25-Epoxyfurost-5-ene-3beta,26-diol
            $ 3-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            (20S,22S,25S)-22,25-Epoxyfurost-5-ene-3beta,26-diol
PRODUCT     UDP
            (20S,22S,25S)-22,25-Epoxyfurost-5-ene-3beta,26-diol
            $ 3-O-beta-D-glucoside
COMMENT     Some other sapogenins can act as glucosyl acceptors. Involved in
            the biosynthesis of plant saponins. Not identical with
            EC 2.4.1.173 or 2.4.1.193.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.192
            ExPASy - ENZYME nomenclature database: 2.4.1.192
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.192
            BRENDA, the Enzyme Database: 2.4.1.192
///
ENTRY       EC 2.4.1.193
NAME        Sarsapogenin 3beta-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:(25S)-5beta-spirostan-3beta-ol
            3-O-beta-glucosyltransferase
REACTION    UDPglucose + (25S)-5beta-Spirostan-3beta-ol = UDP +
            (25S)-5beta-Spirostan-3beta-ol 3-O-beta-D-glucoside
SUBSTRATE   UDPglucose
            (25S)-5beta-Spirostan-3beta-ol
PRODUCT     UDP
            (25S)-5beta-Spirostan-3beta-ol 3-O-beta-D-glucoside
COMMENT     Specific to 5beta-spirostanols. Involved in the biosynthesis of
            plant saponins. Not identical with EC 2.4.1.173 or 2.4.1.192.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.193
            ExPASy - ENZYME nomenclature database: 2.4.1.193
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.193
            BRENDA, the Enzyme Database: 2.4.1.193
///
ENTRY       EC 2.4.1.194
NAME        4-Hydroxybenzoate 4-O-beta-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase
REACTION    UDPglucose + 4-Hydroxybenzoate = UDP +
            4-(beta-D-glucosyloxy)benzoate
SUBSTRATE   UDPglucose
            4-Hydroxybenzoate
PRODUCT     UDP
            4-(beta-D-glucosyloxy)benzoate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.194
            ExPASy - ENZYME nomenclature database: 2.4.1.194
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.194
            BRENDA, the Enzyme Database: 2.4.1.194
///
ENTRY       EC 2.4.1.195
NAME        Thiohydroximate beta-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:thiohydroximate S-beta-D-glucosyltransferase
REACTION    UDPglucose + Phenylthioacetohydroximate = UDP +
            Desulfoglucotropeolin
SUBSTRATE   UDPglucose
            Phenylthioacetohydroximate
PRODUCT     UDP
            Desulfoglucotropeolin
COMMENT     Involved with EC 2.8.2.24 in the biosynthesis of thioglucosides in
            cruciferous plants.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.195
            ExPASy - ENZYME nomenclature database: 2.4.1.195
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.195
            BRENDA, the Enzyme Database: 2.4.1.195
///
ENTRY       EC 2.4.1.196
NAME        Nicotinate glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:nicotinate N-glucosyltransferase
REACTION    UDPglucose + Nicotinate = UDP + N-Glucosylnicotinate
SUBSTRATE   UDPglucose
            Nicotinate
PRODUCT     UDP
            N-Glucosylnicotinate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.196
            ExPASy - ENZYME nomenclature database: 2.4.1.196
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.196
            BRENDA, the Enzyme Database: 2.4.1.196
///
ENTRY       EC 2.4.1.197
NAME        High-mannose-oligosaccharide beta-1,4-N-
            $acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide
            $ beta-1,4-N-acetylglucosaminyltransferase
REACTION    Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-
            -D-glucosamine to the 4-position of a mannose linked alpha-1,6-
            to the core mannose of high-mannose oligosaccharides produced by
            Dictyostelium discoideum
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            High-mannose oligosaccharide
PRODUCT     UDP
            High-mannose oligosaccharide
COMMENT     The activity of the intersecting mannose residue as acceptor is
            dependent on two other mannose residues attached by alpha-1,3- and
            alpha-1,6 links.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.197
            ExPASy - ENZYME nomenclature database: 2.4.1.197
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.197
            BRENDA, the Enzyme Database: 2.4.1.197
///
ENTRY       EC 2.4.1.198
NAME        Phosphatidylinositol N-acetylglucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:phosphatidylinositol
            $ N-acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + Phosphatidylinositol = UDP +
            N-Acetyl-D-glucosaminylphosphatidylinositol
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Phosphatidylinositol
PRODUCT     UDP
            N-Acetyl-D-glucosaminylphosphatidylinositol
COMMENT     Involved in the formation of the glycosylphosphatidylinositol
            membrane anchor of the trypanosome variant-surface glycoprotein.
PATHWAY     PATH: MAP00563  Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
GENES       HSA: 5277(PIGA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.198
            ExPASy - ENZYME nomenclature database: 2.4.1.198
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.198
            BRENDA, the Enzyme Database: 2.4.1.198
///
ENTRY       EC 2.4.1.199
NAME        beta-Mannosylphosphodecaprenol--mannooligosaccharide
            $ 6-mannosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     beta-D-Mannosylphosphodecaprenol:1,6-alpha-D-
            $mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase
REACTION    beta-D-Mannosylphosphodecaprenol +
            1,6-alpha-D-Mannosyloligosaccharide = Decaprenol phosphate +
            1,6-alpha-D-Mannosyl-1,6-alpha-D-mannosyloligosaccharide
SUBSTRATE   beta-D-Mannosylphosphodecaprenol
            1,6-alpha-D-Mannosyloligosaccharide
PRODUCT     Decaprenol phosphate
            1,6-alpha-D-Mannosyl-1,6-alpha-D-mannosyloligosaccharide
COMMENT     Involved in the formation of mannooligosaccharides in the
            membrane of Mycobacterium smegmatis.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.199
            ExPASy - ENZYME nomenclature database: 2.4.1.199
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.199
            BRENDA, the Enzyme Database: 2.4.1.199
///
ENTRY       EC 2.4.1.200
NAME        Inulin fructotransferase (depolymerizing,
            $ difructofuranose-1,2':2',1-dianhydride-forming)
            Inulin fructotransferase (DFA-I-producing)
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Inulin D-fructosyl-D-fructosyltransferase (1,2':2',1-deanhydride-
            $forming)
REACTION    Removes successive terminal D-fructosyl-D-fructofuranosyl groups
            from inulin as the cyclic 1,2':2',1-dianhydride, leaving a
            residual tetra- or pentasaccharide
SUBSTRATE   Inulin
PRODUCT     D-Fructosyl-D-fructofuranose
COMMENT     cf. EC 2.4.1.93.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.200
            ExPASy - ENZYME nomenclature database: 2.4.1.200
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.200
            BRENDA, the Enzyme Database: 2.4.1.200
///
ENTRY       EC 2.4.1.201
NAME        Mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
            N-Glycosyl-oligosaccharide--glycoprotein
            $ N-acetylglucosamineyltransferase V
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:glycoprotein (N-acetyl-D-glucosamine
            $ to D-mannose of N-acetyl-beta-D-glucosaminyl-1,6-beta-D-
            $(N-acetyl-D-glucosaminyl-1,2-)-beta-D-mannosyl-R) beta-1,4-
            $acetyl-D-glucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine +
            N-Acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-
            $1,2)-beta-D-mannosyl-R = UDP +
            N-Acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-
            $1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            N-Acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-
            $1,2)-beta-D-mannosyl-R
PRODUCT     UDP
            N-Acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-
            $1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R
COMMENT     R represents the remainder of the N-oligosaccharide core of
            asparagine-linked glycopeptides. cf. EC 2.4.1.101, 2.4.1.143,
            2.4.1.144, 2.4.1.145, 2.4.1.146.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.201
            ExPASy - ENZYME nomenclature database: 2.4.1.201
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.201
            BRENDA, the Enzyme Database: 2.4.1.201
///
ENTRY       EC 2.4.1.202
NAME        2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one
            $ 2-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one
            $ 2-D-glucosyltransferase
REACTION    UDPglucose + 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one =
            UDP + 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one
            $ 2-D-glucoside
SUBSTRATE   UDPglucose
            2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one
PRODUCT     UDP
            2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.202
            ExPASy - ENZYME nomenclature database: 2.4.1.202
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.202
            BRENDA, the Enzyme Database: 2.4.1.202
///
ENTRY       EC 2.4.1.203
NAME        Zeatin O-beta-D-glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:zeatin O-beta-D-glucosyltransferase
REACTION    UDPglucose + Zeatin = UDP + O-beta-D-Glucosylzeatin
SUBSTRATE   UDPglucose
            Zeatin
            UDPxylose
PRODUCT     UDP
            O-beta-D-Glucosylzeatin
            O-beta-D-Xyloxylzeatin
COMMENT     UDPxylose can also act as donor (cf. EC 2.4.1.204).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.203
            ExPASy - ENZYME nomenclature database: 2.4.1.203
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.203
            BRENDA, the Enzyme Database: 2.4.1.203
///
ENTRY       EC 2.4.1.204
NAME        Zeatin O-beta-D-xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-D-xylose:zeatin O-beta-D-xylosyltransferase
REACTION    UDP-D-xylose + Zeatin = UDP + O-beta-D-Xylosylzeatin
SUBSTRATE   UDP-D-xylose
            Zeatin
PRODUCT     UDP
            O-beta-D-Xylosylzeatin
COMMENT     Does not act on UDPglucose (cf. EC 2.4.1.203).
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.204
            ExPASy - ENZYME nomenclature database: 2.4.1.204
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.204
            BRENDA, the Enzyme Database: 2.4.1.204
///
ENTRY       EC 2.4.1.205
NAME        Galactogen 6-beta-galactosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPgalactose:galactogen beta-1,6-D-galactosyltransferase
REACTION    UDPgalactose + Galactogen = UDP + 1,6-beta-D-Galactosylgalactogen
SUBSTRATE   UDPgalactose
            Galactogen
PRODUCT     UDP
            1,6-beta-D-Galactosylgalactogen
COMMENT     Galactogen from Helix pomatia is the most effective acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.205
            ExPASy - ENZYME nomenclature database: 2.4.1.205
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.205
            BRENDA, the Enzyme Database: 2.4.1.205
///
ENTRY       EC 2.4.1.206
NAME        Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-
            glucosylceramide beta-1,3-acetylglucosaminyltransferase
REACTION    UDP-N-acetyl-D-glucosamine + D-Galactosyl-1,4-beta-D-
            $glucosylceramide = UDP +
            N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            D-Galactosyl-1,4-beta-D-glucosylceramide
PRODUCT     UDP
            N-Acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.206
            ExPASy - ENZYME nomenclature database: 2.4.1.206
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.206
            BRENDA, the Enzyme Database: 2.4.1.206
///
ENTRY       EC 2.4.1.207
NAME        Xyloglucan endotransglycolase
            endo-Xyloglycan transferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
REACTION    Breaks a beta-(1,4) bond in the backbone of a a Xyloglucan and
            transfers the Xyloglucanosyl segment on to O-4 of the non-reducing
            terminal Glucose residue of an acceptor, which can be a Xylogluran
            or an Oligosaccharide of Xyloglucan.
COMMENT     Does not use cello-Oligosaccharides as eighter donor or acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.207
            ExPASy - ENZYME nomenclature database: 2.4.1.207
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.207
///
ENTRY       EC 2.4.1.208
NAME        Diglucosyl diacylglycerol (DGlcDAG) synthase
            Monoglucosyl diacylglycerol (1->2) glucosyltransferase
            MGlcDAG (1->2) glucosyltransferase
            DGlcDAG synthase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
REACTION    UDPglucose + 1,2-Diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol =
            1,2-Diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D-
            $glucopyranosyl)sn-glycerol + UDP
SUBSTRATE   UDPglucose
            1,2-Diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol
PRODUCT     1,2-Diacyl-3-O-(alpha-D-glucopyranosyl(1->2)-O-alpha-D-
            $glucopyranosyl)sn-glycerol
            UDP
COFACTOR    Magnesium
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.208
            ExPASy - ENZYME nomenclature database: 2.4.1.208
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.208
///
ENTRY       EC 2.4.1.209
NAME        cis-p-Coumarate glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     UDPglucose:cis-p-coumarate beta-D-glucosyltransferase
REACTION    UDPglucose + cis-p-Coumarate = 4'-O-beta-D-Glucosyl-cis-p-
            coumarate + UDP
SUBSTRATE   UDPglucose
            cis-p-Coumarate
PRODUCT     4'-O-beta-D-Glucosyl-cis-p-coumarate
            UDP
COMMENT     cis-Caffeic acid also serves as a glucosyl acceptor with the
            enzyme from Sphagnum fallax kinggr. The corresponding trans-isomers
            are not substrates.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.209
            ExPASy - ENZYME nomenclature database: 2.4.1.209
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.209
///
ENTRY       EC 2.4.1.210
NAME        Limonoid glucosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Hexosyltransferases
SYSNAME     Uridine diphosphoglucose-limonoid glucosyltransferase
REACTION    UDPglucose + Limonin = Glucosyl-limonin + UDP
SUBSTRATE   UDPglucose
            Limonin
PRODUCT     Glucosyl-limonin
            UDP
COMMENT     The enzyme purified from navel orange albedo tissue also acts on
            the related tetranortriterpenoid nomilin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.1.210
            ExPASy - ENZYME nomenclature database: 2.4.1.210
            WIT (What Is There) Metabolic Reconstruction: 2.4.1.210
///
ENTRY       EC 2.4.2.1
NAME        Purine-nucleoside phosphorylase
            Inosine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Purine-nucleoside:orthophosphate ribosyltransferase
REACTION    Purine nucleoside + Orthophosphate = Purine +
            alpha-D-Ribose 1-phosphate
SUBSTRATE   Purine nucleoside
            Orthophosphate
PRODUCT     Purine
            alpha-D-Ribose 1-phosphate
COMMENT     Specificity not completely determined. Can also catalyse ribosyl-
            transferase reactions of the type catalysed by EC 2.4.2.5.
            (EC 2.4.2.5 Nucleoside ribosyltransferase)
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b4384(deoD)
            ECE: Z5986(deoD)
            ECS: ECs5343
            YPE: YPO0440(deoD)
            HIN: HI0518(deoD)
            PMU: PM1291(deoD)
            VCH: VC2347 VCA0053
            BUC: BU541(deoD)
            HPY: HP1178(deoD_oe_HP1178)
            HPJ: jhp1104
            MLO: mll0765 mlr3159
            SME: SMc04123(deoD)
            BSU: BG11330(pupG) BG12581(deoD)
            BHA: BH1531 BH1532
            SAU: SA0131(pnp) SA1940(deoD)
            SAV: SAV0130(pnp) SAV2124(deoD)
            LLA: L156559(deoD)
            SPY: SPy0892(punA) SPy0894(deoD2)
            SPN: SP0831 SP0835
            SPR: spr0734(pnp) spr0738(deoD)
            CAC: CAC2064(deoD)
            MGE: MG049(deoD)
            MPN: D09_orf238(deoD)
            MPU: MYPU_6450(deoD)
            UUR: UU281(deoD)
            MTU: Rv3307(deoD)
            MTC: MT3406
            MLE: ML0707(deoD)
            TPA: TP0734
            DRA: DR2166
            AAE: aq_568(deoD)
            TMA: TM1596 TM1737
            APE: APE0993
            SSO: SSO1519(deoD)
            SCE: YLR209C(YLR209C)
            SPO: SPAC1805.16C(spac1805.16c)
            CEL: K02D7.1
            DME: CG16758 CG16758_1 CG16758_2 CG16758_3
            MMU: 97365
            HSA: 4860
DISEASE     MIM: 164050  Nucleoside phosphorylase
MOTIF       PS: PS01232  [GST]-x-G-[LIVM]-G-x-[PA]-S-x-[GSTA]-I-x(3)-E-L
            PS: PS01240  [LIV]-x(3)-G-x(2)-H-x-[LIVMFY]-x(4)-[LIVMF]-x(3)-[ATV]-
                         x(1,2)-[LIVM]-x-[ATV]-x(4)-[GN]-x(3,4)-[LIVMF](2)-x(2)-
                         [STN]-[SA]-x-G-[GS]-[LIVM]
STRUCTURES  PDB: 1A69  1A9O  1A9P  1A9Q  1A9R  1A9S  1A9T  1B8N  1B8O  1ECP  
                 1FXU  1G2O  1I80  1PBN  1QE5  1ULA  1ULB  1VFN  3PNP  4PNP  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.1
            ExPASy - ENZYME nomenclature database: 2.4.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.1
            BRENDA, the Enzyme Database: 2.4.2.1
            SCOP (Structural Classification of Proteins): 2.4.2.1
///
ENTRY       EC 2.4.2.2
NAME        Pyrimidine-nucleoside phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Pyrimidine-nucleoside:orthophosphate alpha-D-ribosyltransferase
REACTION    Pyrimidine nucleoside + Orthophosphate = Pyrimidine +
            alpha-D-Ribose 1-phosphate
SUBSTRATE   Pyrimidine nucleoside
            Orthophosphate
PRODUCT     Pyrimidine
            alpha-D-Ribose 1-phosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       BSU: BG10985(pdp)
            BHA: BH1533(pdp)
            SAU: SA1938(pdp)
            SAV: SAV2122(pdp)
            LLA: L64175(pdp)
            SPN: SP0842
            SPR: spr0744(pdp)
            CAC: CAC1546(deoA)
            DRA: DR0443
            TMA: TM1653
MOTIF       PS: PS00647  S-[GS]-R-[GA]-[LIV]-x(2)-[TA]-[GA]-G-T-x-D-x-[LIV]-E
STRUCTURES  PDB: 1BRW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.2
            ExPASy - ENZYME nomenclature database: 2.4.2.2
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.2
            BRENDA, the Enzyme Database: 2.4.2.2
            SCOP (Structural Classification of Proteins): 2.4.2.2
///
ENTRY       EC 2.4.2.3
NAME        Uridine phosphorylase
            Pyrimidine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Uridine:orthophosphate ribosyltransferase
REACTION    Uridine + Orthophosphate = Uracil + alpha-D-Ribose 1-phosphate
SUBSTRATE   Uridine
            Orthophosphate
PRODUCT     Uracil
            alpha-D-Ribose 1-phosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b3831(UDP)
            ECE: Z5353(udp)
            ECS: ECs4761
            YPE: YPO3786(udp)
            HIN: HI0280(UDP)
            PMU: PM1572(udp)
            VCH: VC1034 VCA0134
            LLA: L54803(udp)
            SPY: SPy1869(udp)
            TPA: TP1027
            HAL: VNG0893G(udp2) VNG1850G(udp1)
            APE: APE2105
            DME: CG6330
            HSA: 7378
MOTIF       PS: PS01232  [GST]-x-G-[LIVM]-G-x-[PA]-S-x-[GSTA]-I-x(3)-E-L
STRUCTURES  PDB: 1K3F  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.3
            ExPASy - ENZYME nomenclature database: 2.4.2.3
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.3
            BRENDA, the Enzyme Database: 2.4.2.3
///
ENTRY       EC 2.4.2.4
NAME        Thymidine phosphorylase
            Pyrimidine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Thymidine:orthophosphate deoxyribosyltransferase
REACTION    Thymidine + Orthophosphate = Thymine +
            2-Deoxy-D-ribose 1-phosphate
SUBSTRATE   Thymidine
            Orthophosphate
PRODUCT     Thymine
            2-Deoxy-D-ribose 1-phosphate
COMMENT     The enzyme in some tissues also catalyses deoxyribosyltransferase
            reactions of the type catalysed by EC 2.4.2.6.
            (EC 2.4.2.6 Nucleoside deoxyribosyltramsferase)
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b4382(deoA)
            ECE: Z5984(deoA)
            ECS: ECs5341
            YPE: YPO0437(deoA)
            VCH: VC2349
            MLO: mlr3160
            SME: SMc04122(deoA)
            ATU: AGR_C_214
            MGE: MG051(deoA)
            MPN: D09_orf421(deoA)
            MPU: MYPU_6460(deoA)
            UUR: UU368(deoA)
            MTU: Rv3314c(deoA)
            MTC: MT3415
            MJA: MJ0667
            AFU: AF1341(deoA-1) AF1342(deoA-2)
            PHO: PH1598
            PAB: PAB1982(deoA)
            HSA: 1890(ECGF1)
DISEASE     MIM: 131222  Endothelial cell growth factor-1, platelet-derived
MOTIF       PS: PS00647  S-[GS]-R-[GA]-[LIV]-x(2)-[TA]-[GA]-G-T-x-D-x-[LIV]-E
STRUCTURES  PDB: 2TPT  1TPT  1OTP  1AZY  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.4
            ExPASy - ENZYME nomenclature database: 2.4.2.4
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.4
            BRENDA, the Enzyme Database: 2.4.2.4
            SCOP (Structural Classification of Proteins): 2.4.2.4
///
ENTRY       EC 2.4.2.5
NAME        Nucleoside ribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nucleoside:purine(pyrimidine) D-ribosyltransferase
REACTION    D-Ribosyl-base1 + Base2 = D-Ribosyl-base2 + Base1
SUBSTRATE   D-Ribosyl-base1
            Base2
            Adenosine
            Guanosine
            Cytidine
            Thymidine
            Adenine
            Guanine
            Cytosine
            Thymine
PRODUCT     D-Ribosyl-base2
            Base1
            Adenosine
            Guanosine
            Cytidine
            Thymidine
            Adenine
            Guanine
            Cytosine
            Thymine
COMMENT     Base1 and base2 represent various purines and pyrimidines.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.5
            ExPASy - ENZYME nomenclature database: 2.4.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.5
            BRENDA, the Enzyme Database: 2.4.2.5
///
ENTRY       EC 2.4.2.6
NAME        Nucleoside deoxyribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase
REACTION    2-Deoxy-D-ribosyl-base1 + Base2 = 2-Deoxy-D-ribosyl-base2 + Base1
SUBSTRATE   2-Deoxy-D-ribosyl-base1
            Base2
            Deoxyadenosine
            Deoxyguanosine
            Deoxycytidine
            Deoxythymidine
            Adenine
            Guanine
            Cytosine
            Thymine
PRODUCT     2-Deoxy-D-ribosyl-base2
            Base1
            Deoxyadenosine
            Deoxyguanosine
            Deoxycytidine
            Deoxythymidine
            Adenine
            Guanine
            Cytosine
            Thymine
COMMENT     Base1 and base2 represent various purines and pyrimidines.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
STRUCTURES  PDB: 1F8X  1F8Y  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.6
            ExPASy - ENZYME nomenclature database: 2.4.2.6
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.6
            BRENDA, the Enzyme Database: 2.4.2.6
            SCOP (Structural Classification of Proteins): 2.4.2.6
///
ENTRY       EC 2.4.2.7
NAME        Adenine phosphoribosyltransferase
            AMP pyrophosphorylase
            Transphosphoribosidase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     AMP:pyrophosphate phosphoribosyltransferase
REACTION    AMP + Pyrophosphate = Adenine +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   AMP
            Pyrophosphate
            5-Amino-1-ribofuranosylimidazole-4-carboxyamide
PRODUCT     Adenine
            5-Phospho-alpha-D-ribose 1-diphosphate
            5-Amino-4-imidazolecarboxyamide
COMMENT     5-Amino-4-imidazolecarboxyamide can replace adenine.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0469(apt)
            ECE: Z0586(apt)
            ECS: ECs0522
            YPE: YPO3123(apt)
            HIN: HI1230(apt)
            PMU: PM0363(apt)
            VCH: VC1053
            PAE: PA1543(apt)
            NME: NMB1662
            NMA: NMA1920(apt)
            HPY: HP0572(apt)
            HPJ: jhp0519
            CJE: Cj0927(apt)
            MLO: mll2701
            SME: SMc02698(apt)
            BSU: BG12568(apt)
            BHA: BH1241(apt)
            SAU: SA1461(apt)
            SAV: SAV1622(apt)
            LLA: L22735(apt)
            SPY: SPy0927(apt)
            SPN: SP1577
            SPR: spr1435(apt)
            CAC: CAC2275(apt)
            MGE: MG276(apt)
            MPN: F11_orf133(apt)
            MPU: MYPU_3220(apt)
            UUR: UU488(apt)
            MTU: Rv2584c(apt)
            MTC: MT2661
            BBU: BB0777(apt)
            TPA: TP1039
            SYN: sll1430(apt)
            DRA: DR0878
            TMA: TM1384
            MJA: MJ1655(apt)
            MTH: MTH1320
            HAL: VNG0559G(apt)
            APE: APE0060
            SCE: YDR441C(APT2) YML022W(APT1)
            SPO: SPAC23A1.03(spac23a1.03)
            ATH: At1g27450(F17L21.24) At1g80050(F18B13.14) At4g22570(F7K2.150)
            CEL: T19B4.3
            DME: CG18315
            MMU: 88061(Aprt)
            HSA: 353(APRT)
DISEASE     MIM: 102600  Adenine phosphoribosyltransferase
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.7
            ExPASy - ENZYME nomenclature database: 2.4.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.7
            BRENDA, the Enzyme Database: 2.4.2.7
///
ENTRY       EC 2.4.2.8
NAME        Hypoxanthine phosphoribosyltransferase
            Hypoxanthine--guanine phosphoribosyltransferase
            IMP pyrophospharylase
            Transphosphoribosidase
            Guanine phosphoribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     IMP:pyrophosphate phosphoribosyltransferase
REACTION    IMP + Pyrophosphate = Hypoxanthine +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   IMP
            Pyrophosphate
            9-(5-Phospho-1-ribofuranosyl)-6-mercaptopurine
            GMP
PRODUCT     Hypoxanthine
            Guanine
            6-Mercaptopurine
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     Guanine and 6-mercaptopurine can replace hypoxanthine.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0125(hpt)
            ECE: Z0136(hpt)
            ECS: ECs0129
            YPE: YPO3408(hpt)
            HIN: HI1153(hpt)
            PMU: PM0121(hpt)
            XFA: XF2354
            VCH: VC0585
            BUC: BU195(hpt)
            NME: NMB2047
            NMA: NMA0389(hpt)
            MLO: mll3520
            SME: SMc00719(hpt)
            CCR: CC2214
            BSU: BG10131(hprT)
            BHA: BH0084(hprT)
            SAU: SA0468
            SAV: SAV0500(hprT)
            LLA: L160442(hprT) L25115(hpt)
            SPN: SP0012
            SPR: spr0011(hgt)
            CAC: CAC3203(hprT)
            MGE: MG458(hpt)
            MPN: K05_orf175(hpt)
            MPU: MYPU_5510(hpt)
            UUR: UU104(hpt)
            MTU: Rv3624c(hpt)
            MTC: MT3726
            MLE: ML0214(hpt)
            DRA: DR1376
            AAE: aq_544(hpt)
            TMA: TM0206
            APE: APE2071
            MMU: 96217(Hprt)
            HSA: 3251(HPRT1)
DISEASE     MIM: 308000  Hypoxanthine phosphoribosyltransferase 1
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
STRUCTURES  PDB: 1TC2  1DQN  1D6N  1CJB  1BZY  1TC1  1QK5  1QK4  1QK3  1HMP  
                 1DQP  1FSG  1HGX  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.8
            ExPASy - ENZYME nomenclature database: 2.4.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.8
            BRENDA, the Enzyme Database: 2.4.2.8
            SCOP (Structural Classification of Proteins): 2.4.2.8
///
ENTRY       EC 2.4.2.9
NAME        Uracil phosphoribosyltransferase
            UMP pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UMP:pyrophosphate phosphoribosyltransferase
REACTION    UMP + Pyrophosphate = Uracil + 5-Phospho-alpha-D-ribose
            $ 1-diphosphate
SUBSTRATE   UMP
            Pyrophosphate
PRODUCT     Uracil
            5-Phospho-alpha-D-ribose 1-diphosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2498(upp)
            ECE: Z3761(upp)
            ECS: ECs3360
            YPE: YPO2827(upp)
            HIN: HI1228(upp)
            PMU: PM0019(upp)
            VCH: VC2225
            PAE: PA4646(upp)
            NME: NMB0774
            NMA: NMA0985(upp)
            CJE: Cj1286c(upp)
            MLO: mll3162
            SME: SMc04121(upp)
            ATU: AGR_C_216
            CCR: CC2268
            BSU: BG10945(upp)
            BHA: BH3764(upp)
            SAU: SA1914(upp)
            SAV: SAV2099(upp)
            LLA: L175538(upp)
            SPY: SPy0392(upp)
            SPN: SP0745
            SPR: spr0655(upp)
            CAC: CAC2879(upp)
            MGE: MG030(upp)
            MPN: B01_orf178(upp)
            MPU: MYPU_3150(upp)
            UUR: UU116(upp)
            MTU: Rv3309c(upp)
            MTC: MT3408
            CMU: TC0833
            TPA: TP0448
            SYN: sll1035(upp)
            DRA: DR1563
            AAE: aq_2163(uraP)
            TMA: TM0721
            MTH: MTH1114
            HAL: VNG2305C
            PAB: PAB1839
            APE: APE0545
            SSO: SSO0231(upP)
            STO: ST0281
            SCE: YHR128W(FUR1)
            SPO: SPAC1002.17C(spac1002.17c) SPAC1B3.01C(spac1b3.01c)
            ATH: At4g26510(M3E9.60)
STRUCTURES  PDB: 1BD3  1BD4  1UPF  1UPU  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.9
            ExPASy - ENZYME nomenclature database: 2.4.2.9
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.9
            BRENDA, the Enzyme Database: 2.4.2.9
            SCOP (Structural Classification of Proteins): 2.4.2.9
///
ENTRY       EC 2.4.2.10
NAME        Orotate phosphoribosyltransferase
            Orotidylic acid phosphorylase
            Orotidine-5'-phosphate pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Orotidine-5'-phosphate:pyrophosphate phosphoribosyltransferase
REACTION    Orotidine 5'-phosphate + Pyrophosphate = Orotate +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   Orotidine 5'-phosphate
            Pyrophosphate
PRODUCT     Orotate
            5-Phospho-alpha-D-ribose 1-diphosphate
            UMP
            CO2
COMMENT     The enzyme from higher eucaryotes also catalyses the reaction
            listed as EC 4.1.1.23.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b3642(pyrE)
            ECE: Z5066(pyrE)
            ECS: ECs4517
            YPE: YPO0045(pyrE)
            HIN: HI0272(pyrE)
            PMU: PM1877(pyrE)
            XFA: XF0153
            VCH: VC0211
            PAE: PA5331(pyrE)
            BUC: BU559(pyrE)
            NME: NMB1874
            NMA: NMA0582(pyrE)
            HPY: HP1257(pyrE)
            HPJ: jhp1178
            CJE: Cj0233c(pyrE)
            MLO: mll5916 mlr7756
            SME: SMc02165(pyrE)
            CCR: CC1555
            BSU: BG10720(pyrE)
            BHA: BH2532(pyrE)
            SAU: SA1048(pyrE)
            SAV: SAV1192(pyrE)
            LLA: L80411(pyrE)
            SPY: SPy0901(pyrE)
            SPN: SP0702
            SPR: spr0614(pyrE)
            CAC: CAC0027(pyrE)
            MTU: Rv0382c(umpA)
            MTC: MT0395
            MLE: ML2487
            CPN: CPn0608
            CPA: CP0139
            CPJ: CPj0608
            SYN: slr0185(umpS)
            DRA: DR0447
            AAE: aq_1907
            TMA: TM0331
            MJA: MJ1109(pyrE) MJ1646
            MTH: MTH1860 MTH876
            AFU: AF0386 AF1741(pyrE)
            HAL: VNG0448G(pyrE1) VNG2118G(pyrE2)
            TAC: Ta0056 Ta1164
            TVO: TVG0009630 TVG1281244
            PHO: PH1128
            PAB: PAB2430(pyrE)
            APE: APE2349
            SSO: SSO0615(pyrE)
            SCE: YML106W(URA5) YMR271C(URA10)
            SPO: SPBC725.15(spbc725.15)
            CEL: R12E2.11 T07C4.1
            DME: CG3593(r-l)
            HSA: 7372(UMPS)
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
            PS: PS00156  [LIVMFTA]-[LIVMF]-x-D-x-K-x(2)-D-I-[GP]-x-T-[LIVMTA]
STRUCTURES  PDB: 1STO  1ORO  1OPR  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.10
            ExPASy - ENZYME nomenclature database: 2.4.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.10
            BRENDA, the Enzyme Database: 2.4.2.10
            SCOP (Structural Classification of Proteins): 2.4.2.10
///
ENTRY       EC 2.4.2.11
NAME        Nicotinate phosphoribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase
REACTION    Nicotinate D-ribonucleotide + Pyrophosphate =
            Nicotinate + 5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   Nicotinate D-ribonucleotide
            Pyrophosphate
PRODUCT     Nicotinate
            5-Phospho-alpha-D-ribose 1-diphosphate
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b0931(pncB)
            ECE: Z1279(pncB)
            ECS: ECs1014
            YPE: YPO1413(pncB)
            XFA: XF1097
            VCH: VCA0098
            PAE: PA4376(pncB2) PA4919(pncB1)
            BUC: BU361(pncB)
            NME: NMB1505
            NMA: NMA1706(pncB)
            MLO: mll4892
            SME: SMc02276(pncB)
            SCE: YOR209C(NPT1)
            SPO: SPAC1486.06(spac1486.06)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.11
            ExPASy - ENZYME nomenclature database: 2.4.2.11
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.11
            BRENDA, the Enzyme Database: 2.4.2.11
///
ENTRY       EC 2.4.2.12
NAME        Nicotinamide phosphoribosyltransferase
            NMN pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nicotinamide-nucleotide:
            $pyrophosphate phospho-alpha-D-ribosyltransferase
REACTION    Nicotinamide D-ribonucleotide + Pyrophosphate = Nicotinamide +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   Nicotinamide D-ribonucleotide
            Pyrophosphate
PRODUCT     Nicotinamide
            5-Phospho-alpha-D-ribose 1-diphosphate
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.12
            ExPASy - ENZYME nomenclature database: 2.4.2.12
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.12
            BRENDA, the Enzyme Database: 2.4.2.12
///
ENTRY       EC 2.4.2.13
NAME        Transferred to EC 2.5.1.6
            Methionine adenosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
COMMENT     Transferred entry. Now EC 2.5.1.6 - Methionine
            adenosyltransferase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.13
            ExPASy - ENZYME nomenclature database: 2.4.2.13
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.13
///
ENTRY       EC 2.4.2.14
NAME        Amidophosphoribosyltransferase
            Phosphoribosyldiphosphate 5-amidotransferase
            Glutamine phosphoribosylpyrophosphate amidotransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     5-Phosphoribosylamine:pyrophosphate phosphoribosyltransferase
            (glutamate-amidating)
REACTION    5-Phospho-beta-D-ribosylamine + Pyrophosphate + L-Glutamate =
            L-Glutamine + 5-Phospho-alpha-D-ribose 1-diphosphate + H2O
SUBSTRATE   5-Phospho-beta-D-ribosylamine
            Pyrophosphate
            L-Glutamate
PRODUCT     L-Glutamine
            5-Phospho-alpha-D-ribose 1-diphosphate
            H2O
COMMENT     Has 4Fe-4S cluster. Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00251  Glutamate metabolism
GENES       ECO: b2312(purF)
            ECE: Z3574(purF)
            ECS: ECs3196
            YPE: YPO2772(purF)
            HIN: HI1207(purF)
            PMU: PM0701(purF)
            XFA: XF1949
            VCH: VC1004
            PAE: PA3108(purF)
            NME: NMB0690
            NMA: NMA0892(purF)
            CJE: Cj0196c(purF)
            MLO: mll7833
            SME: SMc00554(purF)
            CCR: CC1658
            BSU: BG10707(purF)
            BHA: BH0630(purF)
            SAU: SA0922(purF)
            SAV: SAV1056(purF)
            LLA: L171350(purF)
            SPY: SPy0026(purF)
            SPN: SP0046
            SPR: spr0047(purF)
            CAC: CAC1392(purF)
            MTU: Rv0808(purF)
            MTC: MT0829
            MLE: ML2206(purF)
            SYN: sll0757(purF)
            DRA: DR0220
            AAE: aq_1175(purF)
            TMA: TM1247
            MJA: MJ0204(purF)
            MTH: MTH191 MTH646
            AFU: AF0873(purF)
            HAL: VNG1493G(purF)
            TAC: Ta1242
            TVO: TVG0348801
            PHO: PH0240
            PAB: PAB0151(purF)
            SSO: SSO0632(purF-1) SSO0633(purF-2)
            SCE: YMR300C(ADE4)
            SPO: ADE4(ade4)
            CEL: T04A8.5
            DME: CG2867(Prat)
            HSA: 5471(PPAT)
DISEASE     MIM: 172450  Phosphoribosylpyrophosphate amidotransferase
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
            PS: PS00443  <x(0,11)-C-[GS]-[IV]-[LIVMFYW]-[AG]
STRUCTURES  PDB: 1ECJ  1ECG  1GPH  1ECF  1AO0  1ECB  1ECC  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.14
            ExPASy - ENZYME nomenclature database: 2.4.2.14
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.14
            BRENDA, the Enzyme Database: 2.4.2.14
            SCOP (Structural Classification of Proteins): 2.4.2.14
///
ENTRY       EC 2.4.2.15
NAME        Guanosine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Guanosine:orthophosphate D-ribosyltransferase
REACTION    Guanosine + Orthophosphate = Guanine + D-Ribose 1-phosphate
SUBSTRATE   Guanosine
            Deoxyguanosine
            Orthophosphate
PRODUCT     Guanine
            D-Ribose 1-phosphate
            2-Deoxy-D-ribose 1-phosphate
COMMENT     Also acts on deoxyguanosine
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.15
            ExPASy - ENZYME nomenclature database: 2.4.2.15
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.15
            BRENDA, the Enzyme Database: 2.4.2.15
///
ENTRY       EC 2.4.2.16
NAME        Urate-ribonucleotide phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Urate-ribonucleotide:orthophosphate D-ribosyltransferase
REACTION    Urate D-ribonucleotide + Orthophosphate = Urate +
            D-Ribose 1-phosphate
SUBSTRATE   Urate D-ribonucleotide
            Orthophosphate
PRODUCT     Urate
            D-Ribose 1-phosphate
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.16
            ExPASy - ENZYME nomenclature database: 2.4.2.16
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.16
            BRENDA, the Enzyme Database: 2.4.2.16
///
ENTRY       EC 2.4.2.17
NAME        ATP phosphoribosyltransferase
            Phosphoribosyl-ATP pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     1-(5-Phospho-D-ribosyl)-ATP:pyrophosphate phosphoribosyl-
            transferase
REACTION    N1-(5-Phospho-D-ribosyl)-ATP + Pyrophosphate = ATP +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   N1-(5-Phospho-D-ribosyl)-ATP
            Pyrophosphate
PRODUCT     ATP
            5-Phospho-alpha-D-ribose 1-diphosphate
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2019(hisG)
            ECE: Z3181(hisG)
            ECS: ECs2820
            YPE: YPO1549(hisG)
            HIN: HI0468(hisG)
            PMU: PM1195(hisG)
            XFA: XF2220
            VCH: VC1132
            PAE: PA4449(hisG)
            BUC: BU099(hisG)
            NME: NMB1579
            NMA: NMA1768(hisG)
            CJE: Cj1597(hisG)
            MLO: mlr6931
            SME: SMc00917(hisG)
            CCR: CC3511
            BSU: BG12601(hisG)
            BHA: BH3583(hisG)
            SAU: SA2471(hisG)
            SAV: SAV2664(hisG)
            LLA: L0066(hisG)
            CAC: CAC0936(hisG)
            MTU: Rv2121c(hisG)
            MTC: MT2181
            MLE: ML1310(hisG)
            SYN: sll0900(hisG)
            DRA: DR1445
            AAE: aq_1613(hisG)
            TMA: TM1042
            MJA: MJ1204(hisG)
            MTH: MTH119 MTH1506
            AFU: AF0590(hisG)
            HAL: VNG2247G(hisG)
            SSO: SSO0593(hisG)
            SCE: YER055C(HIS1)
            SPO: HIS1(his1)
MOTIF       PS: PS01316  E-x(5)-G-x-[SAG]-x(2)-[IV]-x-D-[LIV]-x(2)-[ST]-G-x-T-
                         [LM]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.17
            ExPASy - ENZYME nomenclature database: 2.4.2.17
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.17
            BRENDA, the Enzyme Database: 2.4.2.17
///
ENTRY       EC 2.4.2.18
NAME        Anthranilate phosphoribosyltransferase
            Phosphoribosyl-anthranilate pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     N-(5-Phospho-D-ribosyl)-anthranilate:pyrophosphate phospho-
            ribosyltransferase
REACTION    N-(5-Phospho-D-ribosyl)anthranilate + Pyrophosphate = Anthranilate
            + 5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   N-(5-Phospho-D-ribosyl)anthranilate
            Pyrophosphate
PRODUCT     Anthranilate
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein together with one or more other components of the system
            for biosynthesis of tryptophan (EC 4.1.1.48, 4.1.3.27, 4.2.1.20,
            5.3.1.24).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1263(trpD)
            ECE: Z2548(trpD)
            ECS: ECs1835
            YPE: YPO2206(trpD)
            HIN: HI1389(trpD)
            PMU: PM0581(trpD)
            XFA: XF0212
            VCH: VC1172
            PAE: PA0650(trpD)
            BUC: BU280(trpD)
            NME: NMB0967
            NMA: NMA1164(trpD)
            HPJ: jhp1201
            CJE: Cj0346(trpD)
            MLO: mlr0614
            SME: SMc00235(trpD)
            CCR: CC1898
            BSU: BG10288(trpD)
            BHA: BH1660(trpD)
            SAU: SA1201(trpD)
            SAV: SAV1354(trpD)
            LLA: L0052(trpD)
            SPN: SP1815
            SPR: spr1635(trpD)
            CAC: CAC3161(trpD)
            MTU: Rv2192c(trpD)
            MTC: MT2248
            MLE: ML0883(trpD)
            SYN: slr1867(trpD)
            DRA: DR1767
            AAE: aq_196(trpD1) aq_209(trpD2)
            TMA: TM0141
            MJA: MJ0234(trpD)
            MTH: MTH1661(trpD)
            AFU: AF1604(trpD)
            HAL: VNG1649G(trpD1)
            TAC: Ta0804
            TVO: TVG1080804
            PAB: PAB2044(trpD)
            APE: APE2551
            SSO: SSO0890(trpD)
            STO: ST1231
            SCE: YDR354W(TRP4)
            SPO: SPBC16G5.08(spbc16g5.08)
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.18
            ExPASy - ENZYME nomenclature database: 2.4.2.18
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.18
            BRENDA, the Enzyme Database: 2.4.2.18
///
ENTRY       EC 2.4.2.19
NAME        Nicotinate-nucleotide pyrophosphorylase (carboxylating)
            Quinolinate phosphoribosyltransferase (decarboxylating)
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase
            (carboxylating)
REACTION    Nicotinate D-ribonucleotide + Pyrophosphate + CO2 =
            Pyridine-2,3-dicarboxylate + 5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   Nicotinate D-ribonucleotide
            Pyrophosphate
            CO2
PRODUCT     Pyridine-2,3-dicarboxylate
            5-Phospho-alpha-D-ribose 1-diphosphate
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b0109(nadC)
            ECE: Z0119(nadC)
            ECS: ECs0113
            YPE: YPO3424(nadC)
            XFA: XF1925
            VCH: VC2422
            PAE: PA4524(nadC)
            NME: NMB0396
            NMA: NMA2088(nadC)
            HPY: HP1355(nadC)
            HPJ: jhp1273
            MLO: mll5833 mll6272 mll9102
            SME: SMc02598(nadC)
            CCR: CC2915
            BSU: BG10868(nadC)
            BHA: BH1219(nadC)
            SPY: SPy0197(nadC)
            SPN: SP2016
            SPR: spr1829(nadC)
            CAC: CAC1023(nadC)
            MTU: Rv1596(nadC)
            MTC: MT1632
            MLE: ML1227(nadC)
            SYN: slr0936(nadC)
            AAE: aq_869(nadC)
            TMA: TM1645
            MJA: MJ0493(nadC)
            MTH: MTH1832
            AFU: AF1839(nadC)
            HAL: VNG1884G(nadC)
            PHO: PH0011
            PAB: PAB2347(nadC)
            SSO: SSO0996
            STO: ST1198
            SCE: YFR047C
            HSA: 23475(QPRT)
STRUCTURES  PDB: 1QPN  1QPO  1QPQ  1QPR  1QAP  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.19
            ExPASy - ENZYME nomenclature database: 2.4.2.19
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.19
            BRENDA, the Enzyme Database: 2.4.2.19
            SCOP (Structural Classification of Proteins): 2.4.2.19
///
ENTRY       EC 2.4.2.20
NAME        Dioxotetrahydropyrimidine phosphoribosyltransferase
            Dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     2,4-Dioxotetrahydropyrimidine-nucleotide:pyrophosphate
            $ phospho-alpha-D-ribosyltransferase
REACTION    a 2,4-Dioxotetrahydropyrimidine D-ribonucleotide + Pyrophosphate =
            a 2,4-Dioxotetrahydropyrimidine +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   2,4-Dioxotetrahydropyrimidine D-ribonucleotide
            Pyrophosphate
PRODUCT     2,4-Dioxotetrahydropyrimidine
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     Acts (in the reverse direction) on uracil and other pyrimidines
            and pteridines containing a 2,4-diketo structure.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.20
            ExPASy - ENZYME nomenclature database: 2.4.2.20
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.20
            BRENDA, the Enzyme Database: 2.4.2.20
///
ENTRY       EC 2.4.2.21
NAME        Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyl
            $transferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Nicotinate-nucleotide:dimethylbenzimidazole
            phospho-D-ribosyltransferase
REACTION    Nicotinate D-ribonucleotide + Dimethylbenzimidazole =
            Nicotinate +
            N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
SUBSTRATE   Nicotinate D-ribonucleotide
            Dimethylbenzimidazole
            Benzimidazole
            Adenine
PRODUCT     Nicotinate
            N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
            7-alpha-D-Ribosyladenine 5'-phosphate
COMMENT     Also acts on benzimidazole, and the clostridial enzyme acts on
            adenine to form 7-alpha-D-ribosyladenine 5'-phosphate.
PATHWAY     PATH: MAP00740  Riboflavin metabolism
            PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b1121(cobB) b1991(cobT)
            ECE: Z3151(cobT)
            ECS: ECs2786
            VCH: VC1237
            PAE: PA1279(cobU)
            MLO: mll0563 mlr1389
            SME: SMc04214(cobU)
            CCR: CC1309
            BHA: BH0284
            CAC: CAC1372(cobT)
            MTU: Rv2207(cobT)
            MTC: MT2263
            MLE: ML0868(cobT)
            DRA: DRA0240
STRUCTURES  PDB: 1JHA  1JH8  1D0V  1D0S  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.21
            ExPASy - ENZYME nomenclature database: 2.4.2.21
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.21
            BRENDA, the Enzyme Database: 2.4.2.21
            SCOP (Structural Classification of Proteins): 2.4.2.21
///
ENTRY       EC 2.4.2.22
NAME        Xanthine phosphoribosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     5-Phospho-alpha-D-ribose-1-diphosphate:xanthine phosphoribosyl-
            transferase
REACTION    5-Phospho-alpha-D-ribose 1-diphosphate + Xanthine =
            (9-D-Ribosylxanthine)-5'-phosphate + Pyrophosphate
SUBSTRATE   5-Phospho-alpha-D-ribose 1-diphosphate
            Xanthine
PRODUCT     (9-D-Ribosylxanthine)-5'-phosphate
            Pyrophosphate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0238(GPT)
            ECE: Z0299(gpt)
            ECS: ECs0265
            YPE: YPO3225(gpt)
            HIN: HI0674(xgprt) HI0692(xgprt)
            PMU: PM1369(gpt)
            VCH: VC2277
            BUC: BU251(gpt)
            HPY: HP0735(gpt)
            HPJ: jhp0672
            CJE: Cj1370
            MLO: mll0141
            SME: SMc00945(gpt)
            AFU: AF0239(gptA-1) AF1789(gptA-2)
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
STRUCTURES  PDB: 1A97  1A96  1A98  1NUL  1A95  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.22
            ExPASy - ENZYME nomenclature database: 2.4.2.22
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.22
            BRENDA, the Enzyme Database: 2.4.2.22
            SCOP (Structural Classification of Proteins): 2.4.2.22
///
ENTRY       EC 2.4.2.23
NAME        Deoxyuridine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Deoxyuridine:orthophosphate deoxy-D-ribosyltransferase
REACTION    Deoxyuridine + Orthophosphate = Uracil + Deoxy-ribose 1-phosphate
SUBSTRATE   Deoxyuridine
            Orthophosphate
PRODUCT     Uracil
            Deoxy-ribose 1-phosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.23
            ExPASy - ENZYME nomenclature database: 2.4.2.23
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.23
            BRENDA, the Enzyme Database: 2.4.2.23
///
ENTRY       EC 2.4.2.24
NAME        1,4-beta-D-Xylan synthase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase
REACTION    UDP-D-xylose + (1,4-beta-D-Xylan)n = UDP + (1,4-beta-D-Xylan)n+1
SUBSTRATE   UDP-D-xylose
            (1,4-beta-D-Xylan)n
PRODUCT     UDP
            (1,4-beta-D-Xylan)n+1
COMMENT     Formerly EC 2.4.1.72.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.24
            ExPASy - ENZYME nomenclature database: 2.4.2.24
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.24
            BRENDA, the Enzyme Database: 2.4.2.24
///
ENTRY       EC 2.4.2.25
NAME        Flavone apiosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDPapiose:7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone
            $ beta-D-apiofuranosyltransferase
REACTION    UDPapiose + 7-O-beta-D-Glucosyl-5,7,4'-trihydroxyflavone =
            UDP +
            7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-
            $trihydroxyflavone
SUBSTRATE   UDPapiose
            7-O-beta-D-Glucosyl-5,7,4'-trihydroxyflavone
PRODUCT     UDP
            7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-
            $trihydroxyflavone
COMMENT     7-O-beta-D-Glucosides of a number of flavonoids and of
            4-substituted phenols can act as acceptors.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.25
            ExPASy - ENZYME nomenclature database: 2.4.2.25
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.25
            BRENDA, the Enzyme Database: 2.4.2.25
///
ENTRY       EC 2.4.2.26
NAME        Protein xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDP-D-xylose:protein beta-D-xylosyltransferase
REACTION    Transfers a beta-D-xylosyl residue from UDP-D-xylose to the serine
            hydroxyl; group of an acceptor protein substrate.
SUBSTRATE   UDP-D-xylose
            Protein serine
PRODUCT     UDP
            Protein serine D-xyloside
COMMENT     Involved in the biosynthesis of the linkage region of
            proteochondroitin sulfate.
GENES       HSA: 64132(XYLT2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.26
            ExPASy - ENZYME nomenclature database: 2.4.2.26
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.26
            BRENDA, the Enzyme Database: 2.4.2.26
///
ENTRY       EC 2.4.2.27
NAME        dTDP-dihydrostreptose--streptidine-6-phosphate
            $ dihydrostreptosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     dTDP-L-dihydrostreptose:streptidine-6-phosphate
            $ dihydrostreptosyltransferase
REACTION    dTDP-L-dihydrostreptose + Streptidine 6-phosphate = dTDP +
            O-1,4-alpha-L-Dihydrostreptosyl-streptidine 6-phosphate
SUBSTRATE   dTDP-L-dihydrostreptose
            Streptidine 6-phosphate
PRODUCT     dTDP
            O-1,4-alpha-L-Dihydrostreptosyl-streptidine 6-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.27
            ExPASy - ENZYME nomenclature database: 2.4.2.27
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.27
            BRENDA, the Enzyme Database: 2.4.2.27
///
ENTRY       EC 2.4.2.28
NAME        5'-methylthioadenosine phosphorylase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     5'-Methylthioadenosine:
            $orthophosphate methylthio-D-ribosyltransferase
REACTION    5'-Methylthioadenosine + Orthophosphate = Adenine +
            5-Methylthio-D-ribose 1-phosphate
SUBSTRATE   5'-Methylthioadenosine
            Orthophosphate
PRODUCT     Adenine
            5-Methylthio-D-ribose 1-phosphate
COMMENT     Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy
            groups.
GENES       MTU: Rv0535(pnp)
            MTC: MT0559
            MJA: MJ0060
            MTH: MTH1596
            AFU: AF1788(mtaP)
            TAC: Ta0332
            TVO: TVG0426892
            PHO: PH0125 PH1143
            PAB: PAB1659(mtaP) PAB2264(mtaP)
            APE: APE1885
            SSO: SSO2343(mtaP) SSO2706(mtaP)
            STO: ST0485 ST0975
            SPO: SPAC16C9.02C(spac16c9.02c)
            CEL: B0228.7
            DME: CG4802
            HSA: 4507(MTAP)
DISEASE     MIM: 156540  Methylthioadenosine phosphorylase
MOTIF       PS: PS01232  [GST]-x-G-[LIVM]-G-x-[PA]-S-x-[GSTA]-I-x(3)-E-L
            PS: PS01240  [LIV]-x(3)-G-x(2)-H-x-[LIVMFY]-x(4)-[LIVMF]-x(3)-[ATV]-
                         x(1,2)-[LIVM]-x-[ATV]-x(4)-[GN]-x(3,4)-[LIVMF](2)-x(2)-
                         [STN]-[SA]-x-G-[GS]-[LIVM]
STRUCTURES  PDB: 1CB0  1CG6  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.28
            ExPASy - ENZYME nomenclature database: 2.4.2.28
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.28
            BRENDA, the Enzyme Database: 2.4.2.28
            SCOP (Structural Classification of Proteins): 2.4.2.28
///
ENTRY       EC 2.4.2.29
NAME        Queuine tRNA-ribosyltransferase
            tRNA-guanine transglycosylase
            Guanine insertion enzyme
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     tRNA-guanine:queuine tRNA-ribosyltransferase
REACTION    tRNA guanine + Queuine = tRNA queuine + Guanine
SUBSTRATE   tRNA guanine
            Queuine
PRODUCT     tRNA queuine
            Guanine
COMMENT     The enzyme also catalyses the exchange of precursors of
            queuine and of guanine itself for guanine located in the
            first position of certain tRNA anticodons.
GENES       ECO: b0406(tgt)
            ECE: Z0505(tgt)
            ECS: ECs0457
            YPE: YPO3191(tgt)
            HIN: HI0244(tgt)
            PMU: PM0229(tgt)
            XFA: XF0223
            VCH: VC0741
            PAE: PA3823(tgt)
            BUC: BU133(tgt)
            NME: NMB0719
            NMA: NMA0928(tgt)
            HPY: HP0281(tgt)
            HPJ: jhp0266
            CJE: Cj1010(tgt)
            RPR: RP721(tgt)
            RCO: RC1097(tgt)
            MLO: mll0721
            SME: SMc01206(tgt)
            CCR: CC1588
            BSU: BG12686(tgt)
            BHA: BH1228(tgt)
            SAU: SA1465(tgt)
            SAV: SAV1626(tgt)
            LLA: L0361(tgt)
            SPY: SPy0203(tgt)
            SPN: SP2058
            SPR: spr1869(tgt)
            CAC: CAC2282(tgt)
            CTR: CT193
            CMU: TC0465
            CPN: CPn0219
            CPA: CP0546
            CPJ: tgt
            BBU: BB0809(tgt)
            SYN: slr0713(tgt)
            DRA: DR2578
            AAE: aq_1308(tgt)
            TMA: TM1561
            MJA: MJ0436(tgtA)
            MTH: MTH176
            AFU: AF0588(tgtA) AF1485(tgtB)
            HAL: VNG1959G(tgtA1)
            TAC: Ta1493
            TVO: TVG1580555
            PHO: PH1116
            PAB: PAB0740(tgtA)
            APE: APE2017
            SSO: SSO0274(tgtA)
            STO: ST0327
            SPO: SPAC1687.19C(spac1687.19c) SPAC2F3.13C(spac2f3.13c)
            CEL: C13B4.2 ZK829.6
            DME: CG4947 CG5384
            HSA: 9097(USP14)
MOTIF       PS: PS00299  K-x(2)-[LIVM]-x-[DESAK]-x(3)-[LIVM]-[PA]-x(3)-Q-x-
                         [LIVM]-[LIVMC]-[LIVMFY]-x-G-x(4)-[DE]
            PS: PS00972  G-[LIVMFY]-x(1,3)-[AGC]-[NASM]-x-C-[FYW]-[LIVMFC]-
                         [NST]-[SACV]-x-[LIVMS]-Q
            PS: PS00973  Y-x-L-x-[SAG]-[LIVMFT]-x(2)-H-x-G-x(4,5)-G-H-Y
            PS: PS50053  Ubiquitin domain profile
STRUCTURES  PDB: 1ENU  1PUD  1WKE  1EFZ  1WKD  1WKF  1F3E  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.29
            ExPASy - ENZYME nomenclature database: 2.4.2.29
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.29
            BRENDA, the Enzyme Database: 2.4.2.29
            SCOP (Structural Classification of Proteins): 2.4.2.29
///
ENTRY       EC 2.4.2.30
NAME        NAD+ ADP-ribosyltransferase
            Poly(ADP-ribose) synthase
            ADP-ribosyltransferase (polymerizing)
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     NAD+:poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase
REACTION    NAD+ + (ADP-D-ribosyl)n-acceptor = Nicotinamide +
            (ADP-D-ribosyl)n+1-acceptor
SUBSTRATE   NAD+
            (ADP-D-ribosyl)n-acceptor
PRODUCT     Nicotinamide
            (ADP-D-ribosyl)n+1-acceptor
COMMENT     The ADP-D-ribosyl group of NAD+ is transferred to an acceptor
            carboxyl group on a histone or the enzyme itself, and further
            ADP-ribosyl groups are transferred to the 2'-position of the
            terminal adenosine moiety, building up a polymer with an average
            chain length of 20-30 units.
GENES       ATH: At4g02390(T14P8.19)
            DME: CG17718(Parp)
            MMU: 87933(Adprp)
            HSA: 10038(ADPRTL2) 10039(ADPRTL3) 142(ADPRT) 143(ADPRTL1)
DISEASE     MIM: 173870  ADP-ribosyltransferase NAD(+)
MOTIF       PS: PS00347  C-[KR]-x-C-x(3)-I-x-K-x(3)-[RG]-x(16,18)-W-[FYH]-H-
                         x(2)-C
            PS: PS50064  Poly(ADP-ribose) polymerase zinc finger domain profile
STRUCTURES  PDB: 4PAX  3PAX  2PAX  2PAW  1QS2  1QS1  1EFY  1PAX  1A26  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.30
            ExPASy - ENZYME nomenclature database: 2.4.2.30
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.30
            BRENDA, the Enzyme Database: 2.4.2.30
            SCOP (Structural Classification of Proteins): 2.4.2.30
///
ENTRY       EC 2.4.2.31
NAME        NAD(P)+--arginine ADP-ribosyltransferase
            ADP-ribosyltransferase
            Mono(ADP-ribosyl)transferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     NAD+:L-arginine ADP-D-ribosyltransferase
REACTION    NAD+ + L-Arginine = Nicotinamide + N2-(ADP-D-ribosyl)-L-arginine
SUBSTRATE   NAD+
            L-Arginine
            NADP+
PRODUCT     Nicotinamide
            N2-(ADP-D-ribosyl)-L-arginine
COMMENT     NADP+ can act as donor; arginine residues in proteins can act as
            acceptors.  Agmatine, arginine methyl ester and guanidine can also
            act as acceptors. The enzyme catalyses the NAD-dependent
            activation of EC 4.6.1.1.  Some bacterial enterotoxins possess
            similar enzymatic activities. cf. EC 2.4.2.36.
GENES       HSA: 417(ART1) 419(ART3)
MOTIF       PS: PS01291  [FY]-x-[FY]-K-x(2)-H-[FY]-x-L-[ST]-x-A
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.31
            ExPASy - ENZYME nomenclature database: 2.4.2.31
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.31
            BRENDA, the Enzyme Database: 2.4.2.31
///
ENTRY       EC 2.4.2.32
NAME        Dolichyl-phosphate D-xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDP-D-xylose:dolichyl-phosphate D-xylosyltrtansferase
REACTION    UDP-D-xylose + Dolichyl phosphate = GDP +
            Dolichyl D-xylosyl phosphate
SUBSTRATE   UDP-D-xylose
            Dolichyl phosphate
PRODUCT     GDP
            Dolichyl D-xylosyl phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.32
            ExPASy - ENZYME nomenclature database: 2.4.2.32
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.32
            BRENDA, the Enzyme Database: 2.4.2.32
///
ENTRY       EC 2.4.2.33
NAME        Dolichyl-xylosyl-phosphate--protein xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     Dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase
REACTION    Dolichyl D-xylosyl phosphate + Protein = Dolichyl phosphate +
            D-Xylosylprotein
SUBSTRATE   Dolichyl D-xylosyl phosphate
            Protein
PRODUCT     Dolichyl phosphate
            D-Xylosylprotein
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.33
            ExPASy - ENZYME nomenclature database: 2.4.2.33
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.33
            BRENDA, the Enzyme Database: 2.4.2.33
///
ENTRY       EC 2.4.2.34
NAME        Indolylacetylinositol arabinosyltransferase
            Arabinosylindolylacetylinositol synthase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDP-L-arabinose:indol-3-ylacetyl-myo-inositol
            $ L-arabinosyltransferase
REACTION    UDP-L-arabinose + Indole-3-ylacetyl-myo-inositol = UDP +
            Indole-3-ylacetyl-myo-inositol L-arabinoside
SUBSTRATE   UDP-L-arabinose
            Indole-3-ylacetyl-myo-inositol
PRODUCT     UDP
            Indole-3-ylacetyl-myo-inositol L-arabinoside
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.34
            ExPASy - ENZYME nomenclature database: 2.4.2.34
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.34
            BRENDA, the Enzyme Database: 2.4.2.34
///
ENTRY       EC 2.4.2.35
NAME        Flavonol-3-O-glycoside xylosyltransferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     UDP-D-xylose:flavonol-3-O-glycoside D-xylosyltransferase
REACTION    UDP-D-xylose + Flavonol 3-O-D-glycoside = UDP +
            Flavonol 3-O-D-xylosylglycoside
SUBSTRATE   UDP-D-xylose
            Flavonol 3-O-D-glycoside
            Flavonol 3-O-D-glucoside
            Flavonol 3-O-D-galactoside
PRODUCT     UDP
            Flavonol 3-O-D-xylosylglycoside
            Flavonol 3-O-D-xylosylglucoside
            Flavonol 3-O-D-xylosylgalactoside
COMMENT     Flavonol 3-O-glucoside, flavonol 3-O-galactoside, and, more
            slowly, rutin, can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.35
            ExPASy - ENZYME nomenclature database: 2.4.2.35
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.35
            BRENDA, the Enzyme Database: 2.4.2.35
///
ENTRY       EC 2.4.2.36
NAME        NAD+--diphthamide ADP-ribosyltransferase
            ADP-ribosyltransferase
            Mono(ADPribosyl)transferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase
REACTION    NAD+ + Peptide diphthamide = Nicotinamide +
            Peptide N-(ADP-D-ribosyl)diphthamide
SUBSTRATE   NAD+
            Peptide diphthamide
PRODUCT     Nicotinamide
            Peptide N-(ADP-D-ribosyl)diphthamide
COMMENT     Diphtheria toxin and some other bacterial toxins catalyse this
            reaction. The acceptor is a diphthamide residue in elongation
            factor 2. cf. EC 2.4.2.31.
GENES       VCH: VC1457
STRUCTURES  PDB: 1XDT  1TOX  1SGK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.36
            ExPASy - ENZYME nomenclature database: 2.4.2.36
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.36
            BRENDA, the Enzyme Database: 2.4.2.36
            SCOP (Structural Classification of Proteins): 2.4.2.36
///
ENTRY       EC 2.4.2.37
NAME        NAD+--dinitrogen-reductase ADP-D-ribosyltransferase
            NAD--azoferredoxin (ADP-ribose)transferase
CLASS       Transferases
            Glycosyltransferases
            Pentosyltransferases
SYSNAME     NAD+:[dinitrogen reductase](ADP-D-ribosyl)transferase
REACTION    NAD+ + [Dinitrogen reductase] = Nicotinamide +
            ADP-D-ribosyl-[dinitrogen reductase]
SUBSTRATE   NAD+
            Dinitrogen reductase
PRODUCT     Nicotinamide
            ADP-D-ribosyl-[dinitrogen reductase]
COMMENT     Together with EC 3.2.2.24, controls the level of activity of
            EC 1.18.6.1.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.2.37
            ExPASy - ENZYME nomenclature database: 2.4.2.37
            WIT (What Is There) Metabolic Reconstruction: 2.4.2.37
            BRENDA, the Enzyme Database: 2.4.2.37
///
ENTRY       EC 2.4.99.1
NAME        beta-Galactoside alpha-2,6-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-
            -glucosamine alpha-2,6-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate +
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +
            alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosamine
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosamine
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosamine
COMMENT     The terminal beta-D-galactosyl residue of the oligosaccharide
            of glycoproteins, as well as lactose, can act as acceptor.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 6480(SIAT1)
DISEASE     MIM: 109675  Sialyltransferase-1 (beta-galactoside
                         alpha-2,6-sialytransferase)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.1
            ExPASy - ENZYME nomenclature database: 2.4.99.1
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.1
            BRENDA, the Enzyme Database: 2.4.99.1
///
ENTRY       EC 2.4.99.2
NAME        Monosialoganglioside sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-
            $(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
            $ N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate +
            D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide = CMP +
            N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosylceramide
SUBSTRATE   CMP-N-acetylneuraminate
            D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-
            $galactosyl-D-glucosylceramide
PRODUCT     CMP
            N-Acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-
            $acetylneuraminyl)-D-galactosyl-D-glucosylceramide
COMMENT     May be identical with EC 2.4.99.4.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: 6481(SIAT2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.2
            ExPASy - ENZYME nomenclature database: 2.4.99.2
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.2
            BRENDA, the Enzyme Database: 2.4.99.2
///
ENTRY       EC 2.4.99.3
NAME        alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:
            $glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
            $ alpha-2,6-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate +
            Glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein =
            CMP +
            Glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)
            $-glycoprotein
SUBSTRATE   CMP-N-acetylneuraminate
            Glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
PRODUCT     CMP
            Glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)
            $-glycoprotein
COMMENT     alpha-N-Acetylgalactosamine linked to threonine or serine is also
            an acceptor, when substituted at the 3-position.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.3
            ExPASy - ENZYME nomenclature database: 2.4.99.3
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.3
            BRENDA, the Enzyme Database: 2.4.99.3
///
ENTRY       EC 2.4.99.4
NAME        beta-Galactoside alpha-2,3-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:
            $beta-D-galactoside alpha-2,3-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + beta-D-Galactosyl-1,3-N-acetyl-
            $alpha-D-galactosaminyl-R = CMP + alpha-N-Acetylneuraminyl-2,3-
            $beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
            Lactose
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-
            $alpha-D-galactosaminyl-R
COMMENT     The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or
            Serine residue in a glycoprotein, or a glycolipid. Lactose can
            also act as acceptor. May be identical with EC 2.4.99.2.
GENES       HSA: 6482(SIAT4A) 6483(SIAT4B) 6484(SIAT4C)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.4
            ExPASy - ENZYME nomenclature database: 2.4.99.4
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.4
            BRENDA, the Enzyme Database: 2.4.99.4
///
ENTRY       EC 2.4.99.5
NAME        Galactosyldiacylglycerol alpha-2,3-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-
            $glycerol N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + 1,2-Diacyl-3-beta-D-galactosyl-sn-
            $glycerol = CMP + 1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-
            $beta-D-galactosyl]-sn-glycerol
SUBSTRATE   CMP-N-acetylneuraminate
            1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
PRODUCT     CMP
            1,2-Diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-
            $sn-glycerol
COMMENT     The beta-D-galactosyl residue of the oligosaccharide of
            glycoproteins may also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.5
            ExPASy - ENZYME nomenclature database: 2.4.99.5
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.5
            BRENDA, the Enzyme Database: 2.4.99.5
///
ENTRY       EC 2.4.99.6
NAME        N-Acetyllactosaminide alpha-2,3-sialyltransferase
            Sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-
            $glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + beta-D-Galactosyl-1,4-N-acetyl-D-
            $glucosaminyl-glycoprotein = CMP + alpha-N-Acetylneuraminyl-
            $2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-
            $glucosaminyl-glycoprotein
COMMENT     Acts on beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl termini on
            glycoprotein.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       HSA: 6487(SIAT6)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.6
            ExPASy - ENZYME nomenclature database: 2.4.99.6
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.6
            BRENDA, the Enzyme Database: 2.4.99.6
///
ENTRY       EC 2.4.99.7
NAME        (alpha-N-Acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-
            $acetylgalactosaminide alpha-2,6-sialyltransferase
            Sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-
            $galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-
            $acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + alpha-N-Acetylneuraminyl-2,3-beta-D-
            $galactosyl-1,3-N-acetyl-D-galactosaminyl-R = CMP +
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactose-1,3-(alpha-N-
            $acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
SUBSTRATE   CMP-N-acetylneuraminate
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-D-
            $galactosaminyl-R
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactose-1,3-(alpha-N-
            $acetylneuraminyl-2,6)-N-acetyl-D-galactosaminyl-R
COMMENT     Attaches N-acetylneuraminic acid in alpha-2,6-lingage to N-acetyl-
            galactosamine only when present in the structure of alpha-N-
            acetyl-meuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminyl-
            R, where R may be protein or p-nitrophenol. Not identical with
            EC 2.4.99.3.
GENES       HSA: 6488(SIAT7)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.7
            ExPASy - ENZYME nomenclature database: 2.4.99.7
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.7
            BRENDA, the Enzyme Database: 2.4.99.7
///
ENTRY       EC 2.4.99.8
NAME        alpha-N-Acetyl-neuraminate alpha-2,8-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-
            $galactoside alpha-2,8-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + alpha-N-Acetylneuraminyl-
            $2,3-beta-D-galactosyl-R = CMP + alpha-N-Acetylneuraminyl-
            $2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R
SUBSTRATE   CMP-N-acetylneuraminate
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-R
            Ganglioside
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-
            $D-galactosyl-R
COMMENT     Gangliosides act as acceptors.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
            PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
GENES       HSA: 6489(SIAT8A)
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.8
            ExPASy - ENZYME nomenclature database: 2.4.99.8
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.8
            BRENDA, the Enzyme Database: 2.4.99.8
///
ENTRY       EC 2.4.99.9
NAME        Lactosylceramide alpha-2,3-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:lactosylceramide
            $ alpha-2,3-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + beta-D-Galactosyl-1,4-beta-D-
            $glucosylceramide = CMP + alpha-N-Acetylneuraminyl-2,3-beta-D-
            $galactosyl-1,4-beta-D-glucosylceramide
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-beta-D-glucosylceramide
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-
            $glucosylceramide
COMMENT     Lactose cannot act as acceptor.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
            PATH: MAP00601  Blood group glycolipid biosynthesis - lact series
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.9
            ExPASy - ENZYME nomenclature database: 2.4.99.9
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.9
            BRENDA, the Enzyme Database: 2.4.99.9
///
ENTRY       EC 2.4.99.10
NAME        Neolactotetraosylceramide alpha-2,3-sialyltransferase
            Sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:neolactotetraosylceramide
            $ alpha-2,3-sialyltransferase
REACTION    CMP-N-acetylneuraminate + beta-D-Galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide =
            CMP + alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-
            $acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-
            $glucosylceramide
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-
            $galactosyl-1,4-D-glucosylceramide
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-
            $beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide
PATHWAY     PATH: MAP00602  Blood group glycolipid biosynthesis - neolact series
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.10
            ExPASy - ENZYME nomenclature database: 2.4.99.10
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.10
            BRENDA, the Enzyme Database: 2.4.99.10
///
ENTRY       EC 2.4.99.11
NAME        Lactosylceramide alpha-2,6-N-sialyltransferase
CLASS       Transferases
            Glycosyltransferases
            Transferring other glycosyl groups
SYSNAME     CMP-N-acetylneuraminate:lactosylceramide
            $ alpha-2,6-N-acetylneuraminyltransferase
REACTION    CMP-N-acetylneuraminate + beta-D-Galactosyl-1,4-beta-D-
            glucosylceramide = CMP + alpha-N-Acetylneuraminyl-2,6-beta-
            $galactosyl-1,4-beta-D-glucosylceramide
SUBSTRATE   CMP-N-acetylneuraminate
            beta-D-Galactosyl-1,4-beta-D-glucosylceramide
PRODUCT     CMP
            alpha-N-Acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosyl
            $ceramide
DBLINKS     IUBMB Enzyme Nomenclature: 2.4.99.11
            ExPASy - ENZYME nomenclature database: 2.4.99.11
            WIT (What Is There) Metabolic Reconstruction: 2.4.99.11
            BRENDA, the Enzyme Database: 2.4.99.11
///
ENTRY       EC 2.5.1.1
NAME        Dimethylallyltranstransferase
            Geranyl-diphosphate synthase
            Prenyltransferase
            Dimethylallyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Dimethylallyl-diphosphate:isopentenyl-diphosphate
            dimethylallyltranstransferase
REACTION    Dimethylallyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + Geranyl diphosphate
SUBSTRATE   Dimethylallyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            Geranyl diphosphate
COMMENT     This enzyme will not accept larger prenyl diphosphates as
            efficient donors.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       MTU: Rv3383c(idsB) Rv3398c(idsA)
            MTC: MT3491 MT3506
            DRA: DR1395
            MJA: MJ0860(idsA)
            MTH: MTH50(idsA)
            AFU: AF2286(idsA)
            HAL: VNG1150G(idsA)
            PHO: PH1072
            PAB: PAB2389(idsA)
            APE: APE1764
            SSO: SSO0061(gdS-1)
            SCE: YJL167W(ERG20)
            SPO: SPAC6F12.13C(spac6f12.13c)
            ATH: At4g17190(dl4630c) At4g36810(AP22.99)
            DME: CG12389(Fpps) CG8593
            HSA: 2224(FDPS) 9453(GGPS1)
MOTIF       PS: PS00444  [LIVMFY]-G-x(2)-[FYL]-Q-[LIVM]-x-D-D-[LIVMFY]-x-[DNG]
            PS: PS00723  [LIVM](2)-x-D-D-x(2,4)-D-x(4)-R-R-[GH]
STRUCTURES  PDB: 1UBV  1UBW  1UBX  1UBY  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.1
            ExPASy - ENZYME nomenclature database: 2.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.1
            BRENDA, the Enzyme Database: 2.5.1.1
            SCOP (Structural Classification of Proteins): 2.5.1.1
///
ENTRY       EC 2.5.1.2
NAME        Thiamin pyridinylase
            Pyrimidine transferase
            Thiaminase I
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase
REACTION    Thiamine + Pyridine = Heteropyrithiamine + 4-Methyl-5-(2'-
            $hydroxyethyl)-thiazole
SUBSTRATE   Thiamine
            Pyridine
PRODUCT     Heteropyrithiamine
            4-Methyl-5-(2'-hydroxyethyl)-thiazole
COMMENT     Various beses and thiol compounds can act instead of pyridine.
PATHWAY     PATH: MAP00730  Thiamine metabolism
STRUCTURES  PDB: 3THI  2THI  4THI  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.2
            ExPASy - ENZYME nomenclature database: 2.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.2
            BRENDA, the Enzyme Database: 2.5.1.2
            SCOP (Structural Classification of Proteins): 2.5.1.2
///
ENTRY       EC 2.5.1.3
NAME        Thiamin-phosphate pyrophosphorylase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     2-Methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:
            $4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-
            $aminopyridine-5-methenyltransferase
REACTION    2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate +
            4-Methyl-5-(2-phosphono-oxyethyl)-thiazole = Pyrophosphate +
            Thiamine monophosphate
SUBSTRATE   2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate
            4-Methyl-5-(2-phosphono-oxyethyl)-thiazole
PRODUCT     Pyrophosphate
            Thiamine monophosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
GENES       ECO: b3993(thiE)
            ECE: Z5568(thiE)
            ECS: ECs4916
            YPE: YPO3740(thiE)
            HIN: HI0417(thie)
            PMU: PM1260(thiE)
            XFA: XF0378
            VCH: VC0062
            PAE: PA3976(thiE)
            NME: NMB2069
            NMA: NMA0363(thiE)
            HPY: HP0843(thiB)
            HPJ: jhp0781
            CJE: Cj1081c(thiE)
            MLO: mll5789
            SME: SMb20618(thiE) SMc03996(thiE2)
            CCR: CC3264
            BSU: BG10572(thiC)
            BHA: BH1431
            SAU: SA1894(thiE)
            SAV: SAV2076(thiE)
            LLA: L0201(thiE)
            SPN: SP0718 SP0725
            SPR: spr0630(thiE) spr0637(thiE)
            CAC: CAC0495(thiC) CAC2920(tenI)
            MTU: Rv0414c(thiE)
            MTC: MT0427
            MLE: ML0300(thiE)
            SYN: sll0635(thiE)
            DRA: DRA0174
            AAE: aq_1366(thiE1) aq_558(thiE2)
            AFU: AF2074(thiE)
            TAC: Ta1277
            TVO: TVG0496174
            PHO: PH1156
            PAB: PAB1645(thiE)
            SCE: YPL214C(THI6)
            SPO: THI4(thi4)
STRUCTURES  PDB: 2TPS  1G67  1G4T  1G4S  1G4P  1G4E  1G6C  1G69  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.3
            ExPASy - ENZYME nomenclature database: 2.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.3
            BRENDA, the Enzyme Database: 2.5.1.3
            SCOP (Structural Classification of Proteins): 2.5.1.3
///
ENTRY       EC 2.5.1.4
NAME        Adenosylmethionine cyclotransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosyl-L-methionine alkyltransferase (cyclizing)
REACTION    S-Adenosyl-L-methionine = 5'-Methylthioadenosine + 2-Aminobutan-
            $4-olide
SUBSTRATE   S-Adenosyl-L-methionine
PRODUCT     5'-Methylthioadenosine
            2-Aminobutan-4-olide
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.4
            ExPASy - ENZYME nomenclature database: 2.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.4
            BRENDA, the Enzyme Database: 2.5.1.4
///
ENTRY       EC 2.5.1.5
NAME        Galactose-6-sulfurylase
            Porphyran sulfatase
            Galactose-6-sulfatase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     D-Galactose-6-sulfate:alkyltransferase (cyclizing)
REACTION    Eliminates sulfate from the D-galactose 6-sulfate residues of
            porphyran producing 3,6-anhydrogalactose residues
SUBSTRATE   D-Galactose 6-sulfate
            Porphyran
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.5
            ExPASy - ENZYME nomenclature database: 2.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.5
            BRENDA, the Enzyme Database: 2.5.1.5
///
ENTRY       EC 2.5.1.6
NAME        Methionine adenosyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     ATP:L-methione S-adenosyltransferase
REACTION    ATP + L-Methionine + H2O = Orthophosphate + Pyrophosphate +
            S-Adenosyl-L-methionine
SUBSTRATE   ATP
            L-Methionine
            H2O
PRODUCT     Orthophosphate
            Pyrophosphate
            S-Adenosyl-L-methionine
COMMENT     Formerly EC 2.4.2.13.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
GENES       ECO: b2942(metK)
            ECE: Z4287(metK)
            ECS: ECs3818
            YPE: YPO0931(metK)
            HIN: HI1172(metK)
            PMU: PM1027(metX)
            XFA: XF0392
            VCH: VC0472
            PAE: PA0546(metK)
            BUC: BU408(metK)
            NME: NMB1799
            NMA: NMA0663(metK)
            HPY: HP0197(metk)
            HPJ: jhp0183
            CJE: Cj1096c(metK)
            MLO: mlr5545 mlr6115
            SME: SMc01109(metK)
            CCR: CC0050
            BSU: BG11840(metK)
            BHA: BH3300(metK)
            SAU: SA1608(metK)
            SAV: SAV1776(metK)
            LLA: L153408(metK)
            SPY: SPy0538 SPy1359(metK)
            SPN: SP0762
            SPR: spr0671(metK)
            CAC: CAC2856(metK)
            MGE: MG047(metk)
            MPN: D09_orf383(metX)
            MPU: MYPU_7020(metK)
            UUR: UU412(metK)
            MTU: Rv1392(metK)
            MTC: MT1437
            MLE: ML0544(metK)
            BBU: BB0376(metK)
            TPA: TP0794
            SYN: sll0927(metX)
            DRA: DR0640
            AAE: aq_1154(metK) aq_1226
            TMA: TM1658
            MJA: MJ1208
            MTH: MTH1376
            AFU: AF0050
            HAL: VNG1297C
            TAC: Ta0059
            TVO: TVG0012665
            PHO: PH1824
            PAB: PAB2094
            APE: APE1596
            SSO: SSO0199(maT)
            STO: ST0235
            SCE: YDR502C(SAM2) YLR180W(SAM1)
            SPO: SAM1(sam1)
            ATH: At4g01850(T7B11.11)
            CEL: C06E7.1 C06E7.3 C49F5.1
            DME: CG2674_1(M(2)21AB) CG2674_3(M(2)21AB) CG2674_4(M(2)21AB)
            HSA: 4143(MAT1A) 4144(MAT2A)
DISEASE     MIM: 250850  Methionine adenosyltransferase I, alpha
MOTIF       PS: PS00376  G-A-G-D-Q-G-x(3)-G-[FYH]
            PS: PS00377  G-[GA]-G-[ASC]-F-S-x-K-[DE]
STRUCTURES  PDB: 1XRC  1XRA  1XRB  1QM4  1MXC  1MXB  1MXA  1FUG  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.6
            ExPASy - ENZYME nomenclature database: 2.5.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.6
            BRENDA, the Enzyme Database: 2.5.1.6
            SCOP (Structural Classification of Proteins): 2.5.1.6
///
ENTRY       EC 2.5.1.7
NAME        UDP-N-acetylglucosamine 1-carboxyvinyltransferase
            Enoylpyruvate transferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyl-
            transferase
REACTION    Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = Orthophosphate
            + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
SUBSTRATE   Phosphoenolpyruvate
            UDP-N-acetyl-D-glucosamine
PRODUCT     Orthophosphate
            UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3189(murA)
            ECE: Z4552(murA)
            ECS: ECs4068
            YPE: YPO3569(murA)
            HIN: HI1081(murA)
            PMU: PM0180(murZ)
            XFA: XF1415
            VCH: VC2514
            PAE: PA4450(murA)
            BUC: BU386(murA)
            NME: NMB0011
            NMA: NMA0258(murA)
            HPY: HP0648(mura)
            HPJ: jhp0593
            CJE: Cj0858c(murA)
            RPR: RP579(murA)
            RCO: RC0883(murA)
            MLO: mll6459 mll7251
            SME: SMc02305(murA)
            CCR: CC2350
            BSU: BG10414(murZ) BG11955(murA)
            BHA: BH3749(murA) BH3784(murZ)
            SAU: SA1902(murA) SA1926(murZ)
            SAV: SAV2111(murZ)
            LLA: L113067(murA1) L134243(murA2)
            SPY: SPy0763 SPy1358(murZ)
            SPN: SP1081 SP1966
            SPR: spr0989(murZ) spr1781(murA)
            CAC: CAC2862(murA) CAC3539(murA)
            MTU: Rv1315(murA)
            MTC: MT1355
            MLE: ML1150(murA)
            CTR: CT455
            CMU: TC0740
            CPN: CPn0571
            CPA: CP0178
            CPJ: murA
            BBU: BB0472(murA)
            TPA: TP0029
            SYN: slr0017(murA)
            DRA: DR1123
            AAE: aq_1281(murA)
            TMA: TM0108
STRUCTURES  PDB: 1EYN  1EJD  1EJC  1DLG  1A2N  1NAW  1UAE  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.7
            ExPASy - ENZYME nomenclature database: 2.5.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.7
            BRENDA, the Enzyme Database: 2.5.1.7
            SCOP (Structural Classification of Proteins): 2.5.1.7
///
ENTRY       EC 2.5.1.8
NAME        tRNA isopentenyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Isopentenyl-diphosphate:tRNA isopentenyltransferase
REACTION    Isopentenyl diphosphate + tRNA = Pyrophosphate +
            tRNA containing 6-isopentenyladenosine
SUBSTRATE   Isopentenyl diphosphate
            tRNA
PRODUCT     Pyrophosphate
            tRNA containing 6-isopentenyladenosine
GENES       ECO: b4171(miaA)
            ECE: Z5778(miaA)
            ECS: ECs5147
            YPE: YPO0372(miaA)
            HIN: HI0068(miaA)
            PMU: PM0905(trpX)
            XFA: XF0090
            VCH: VC0346
            PAE: PA4945(miaA)
            BUC: BU569(miaA)
            NME: NMB0935
            NMA: NMA1130(miaA)
            HPY: HP1415(miaA)
            HPJ: jhp1310
            CJE: Cj0166(miaA)
            RPR: RP510(miaA)
            RCO: RC0656(miaA)
            MLO: mll1448
            SME: SMc01435(miaA)
            CCR: CC2098
            BSU: BG12617(miaA)
            BHA: BH2366(miaA)
            SAU: SA1144(miaA)
            SAV: SAV1290(miaA)
            LLA: L15012(miaA)
            SPY: SPy0921(miaA)
            SPN: SP0671
            SPR: spr0588(miaA)
            CAC: CAC1835(miaA)
            MTU: Rv2727c(miaA)
            MTC: MT2799
            MLE: ML0995(miaA)
            CTR: CT766
            CMU: TC0147
            CPN: CPn0910
            CPA: CP0956
            CPJ: miaA
            BBU: BB0821(miaA)
            TPA: TP0637
            SYN: sll0817(miaA)
            DRA: DR1690
            AAE: aq_1067(miaA)
            TMA: TM0525
            SCE: YOR274W(MOD5)
            SPO: SPAC343.15(spac343.15)
            CEL: ZC395.6
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.8
            ExPASy - ENZYME nomenclature database: 2.5.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.8
            BRENDA, the Enzyme Database: 2.5.1.8
///
ENTRY       EC 2.5.1.9
NAME        Riboflavin synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     6,7-Dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)
            lumazine 2,3-butanediyltransferase
REACTION    2 6,7-Dimethyl-8-(1-D-ribityl)lumazine = Riboflavin +
            4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine
SUBSTRATE   6,7-Dimethyl-8-(1-D-ribityl)lumazine
PRODUCT     Riboflavin
            4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine
COFACTOR    Riboflavin
COMMENT     A flavoprotein (riboflavin)
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0415(ribH) b1662(ribE)
            ECE: Z0516 Z2688(ribE)
            ECS: ECs0468 ECs2371
            YPE: YPO2391(ribE) YPO3182(ribH)
            HIN: HI1303(ribH) HI1613(ribE)
            PMU: PM0650(ribE) PM0731(ribH)
            XFA: XF0952 XF0954
            VCH: VC2268 VC2270
            PAE: PA4053(ribE) PA4055(ribC)
            BUC: BU112(ribE) BU459(ribH)
            NME: NMB0684 NMB1247
            NMA: NMA0886(ribE) NMA1416(ribC)
            HPY: HP0002(ribE) HP1574(ribC)
            HPJ: jhp0002 jhp1482
            CJE: Cj0383c(ribH) Cj1218c(ribA)
            MLO: mll7281 mlr8407 mlr8409
            SME: SMc01609(ribH2) SMc01773(ribE) SMc01777(ribH1)
            CCR: CC0886 CC0888
            BSU: BG10519(ribB) BG10521(ribH)
            BHA: BH1555(ribB) BH1557(ribH)
            SAU: SA1586(ribH) SA1588(ribB)
            SAV: SAV1751 SAV1752 SAV1754(ribB)
            LLA: L0164(ribB) L0166(ribH)
            SPN: SP0175 SP0177
            SPR: spr0161(ribE) spr0163(ribC)
            CAC: CAC0591(ribB) CAC0593(ribH)
            MTU: Rv1412(ribC) Rv1416(ribH)
            MTC: MT1456 MT1459
            MLE: ML0558(ribC) ML0560(ribH)
            CTR: CT405 CT732
            CMU: TC0105 TC0685
            CPN: CPn0532 CPn0873
            CPA: CP0220 CP0996
            CPJ: ribC ribE
            SYN: sll0300(ribC) sll1282(ribH)
            DRA: DR0154 DR0156
            AAE: aq_132(ribH) aq_1707(ribC)
            TMA: TM1825 TM1827
            MJA: MJ0303 MJ1184(ribC)
            MTH: MTH134 MTH1390
            AFU: AF1416(ribC) AF2128(ribE)
            HAL: VNG0630G(ribE) VNG2624G(ribC)
            APE: APE0988 APE1366
            SSO: SSO0400(ribH) SSO0401(ribC)
            STO: ST0393 ST0394
            SCE: YBR256C(RIB5) YOL143C(RIB4)
            SPO: SPBC409.13(spbc409.13) SPCC1450.13C(spcc1450.13c)
MOTIF       PS: PS00693  [LIVMF]-x(5)-G-[STADNQ]-[KREQIYW]-V-N-[LIVM]-E
STRUCTURES  PDB: 1C41  1EJB  1EPS  1HZE  1I18  1I8D  1C2Y  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.9
            ExPASy - ENZYME nomenclature database: 2.5.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.9
            BRENDA, the Enzyme Database: 2.5.1.9
            SCOP (Structural Classification of Proteins): 2.5.1.9
///
ENTRY       EC 2.5.1.10
NAME        Geranyltranstransferase
            Farnesyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-
            transferase
REACTION    Geranyl diphosphate + Isopentenyl diphosphate = Pyrophosphate +
            trans,trans-Farnesyl diphosphate
SUBSTRATE   Geranyl diphosphate
            Isopentenyl diphosphate
            Dimethylallyl diphosphate
PRODUCT     Pyrophosphate
            trans,trans-Farnesyl diphosphate
            Geranyl diphosphate
COMMENT     Some forms of this enzyme will also use dimethylallyl
            diphosphate as a substrate. The enzyme will not accept larger
            prenyl diphosphates as efficient donors.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       ECO: b0421(ispA)
            ECE: Z0524(ispA)
            ECS: ECs0475
            YPE: YPO3176(ispA)
            PMU: PM0533(ispA)
            XFA: XF0661
            VCH: VC0890
            PAE: PA4043
            CJE: Cj1644(ispA)
            MLO: mlr3784 mlr6368
            SME: SMc03884(ispA)
            CCR: CC2069
            BSU: BG11714(yqiD)
            BHA: BH2781
            SAU: SA1352(ispA)
            SAV: SAV1510
            LLA: L80459(ispA)
            SPY: SPy1498(fps)
            SPN: SP1205
            SPR: spr1087(ispA)
            MTU: Rv3383c(idsB) Rv3398c(idsA)
            MTC: MT3491 MT3506
            DRA: DR1395
            MJA: MJ0860(idsA)
            MTH: MTH50(idsA)
            APE: APE1764
            SSO: SSO0061(gdS-1)
            SCE: YJL167W(ERG20)
            SPO: SPAC6F12.13C(spac6f12.13c)
            ATH: At4g17190(dl4630c) At4g36810(AP22.99)
            DME: CG12389(Fpps) CG8593
            HSA: 2224(FDPS) 9453(GGPS1)
MOTIF       PS: PS00444  [LIVMFY]-G-x(2)-[FYL]-Q-[LIVM]-x-D-D-[LIVMFY]-x-[DNG]
            PS: PS00723  [LIVM](2)-x-D-D-x(2,4)-D-x(4)-R-R-[GH]
STRUCTURES  PDB: 1FPS  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.10
            ExPASy - ENZYME nomenclature database: 2.5.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.10
            BRENDA, the Enzyme Database: 2.5.1.10
            SCOP (Structural Classification of Proteins): 2.5.1.10
///
ENTRY       EC 2.5.1.11
NAME        trans-Octaprenyltranstransferase
            all-trans-Nonaprenyl-diphosphate synthase
            Solanesyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     (E)-Octaprenyl-diphosphate:isopentenyl-diphosphate
            $ octaprenyltracetransferase
REACTION    all-trans-Octaprenyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + all-trans-Nonaprenyl diphosphate
SUBSTRATE   all-trans-Octaprenyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            all-trans-Nonaprenyl diphosphate
COMMENT     This enzyme will also use geranyl diphosphate and all-trans-
            prenyl diphosphates of intermediate size as donors, but not
            dimenthylallyl diphosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.11
            ExPASy - ENZYME nomenclature database: 2.5.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.11
            BRENDA, the Enzyme Database: 2.5.1.11
///
ENTRY       EC 2.5.1.12
NAME        Deleted entry
            Glutathione S-alkyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
COMMENT     Deleted entry. Now included with EC 2.5.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.12
            ExPASy - ENZYME nomenclature database: 2.5.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.12
///
ENTRY       EC 2.5.1.13
NAME        Deleted entry
            Glutathione S-aryltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
COMMENT     Deleted entry. Now included with EC 2.5.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.13
            ExPASy - ENZYME nomenclature database: 2.5.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.13
///
ENTRY       EC 2.5.1.14
NAME        Deleted entry
            Glutathione S-aralkyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
COMMENT     Deleted entry. Now included with EC 2.5.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.14
            ExPASy - ENZYME nomenclature database: 2.5.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.14
///
ENTRY       EC 2.5.1.15
NAME        Dihydropteroate synthase
            Dihydropteroate pyrophosphorylase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate
            :4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-
            methenyltransferase
REACTION    2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
            + 4-Aminobenzoate = Pyrophosphate + Dihydropteroate
SUBSTRATE   2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate
            4-Aminobenzoate
PRODUCT     Pyrophosphate
            Dihydropteroate
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b3177(folP)
            ECE: Z4539(folP)
            ECS: ECs4056
            YPE: YPO3501(folP)
            HIN: HI1336(folP) HI1464(folP)
            PMU: PM0439(folP)
            XFA: XF0091
            VCH: VC0638
            PAE: PA4750(folP)
            NME: NMB1691
            NMA: NMA1950(dhpS)
            HPY: HP1232(folP)
            HPJ: jhp1153
            CJE: Cj0585(folP)
            MLO: mll0788
            SME: SMc00462(folP)
            CCR: CC3224
            BSU: BG10140(sul)
            BHA: BH0093(sul)
            SAU: SA0472(folP)
            SAV: SAV0504
            LLA: L0176(folP)
            SPY: SPy1098(folP)
            SPN: SP0289
            SPR: spr0266(sulA)
            CAC: CAC2926(sul)
            MTU: Rv1207(folP2) Rv3608c(folP)
            MTC: MT1245 MT3712
            MLE: ML0224(folP) ML1063(folP2)
            CTR: CT613
            CMU: TC0903
            CPN: CPn0758
            CPA: CP1114
            CPJ: folP
            SYN: slr2026(folP)
            DRA: DR0168
            AAE: aq_1468(folP)
            TMA: TM0040
            AFU: AF1414
            HAL: VNG0412G(folP)
            TAC: Ta0079
            TVO: TVG0162982
            SCE: YNL256W(FOL1)
MOTIF       PS: PS00792  [LIVM]-x-[AG]-[LIVMF](2)-N-x-T-x-D-S-F-x-D-x-[SG]
            PS: PS00793  [GE]-[SA]-x-[LIVM](2)-D-[LIVM]-G-[GP]-x(2)-[STA]-x-P
            PS: PS00794  [KRHD]-x-[GA]-[PSAE]-R-x(2)-D-[LIV]-D-[LIVM](2)
STRUCTURES  PDB: 1AD4  1AJ2  1AJZ  1EYE  1AJ0  1AD1  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.15
            ExPASy - ENZYME nomenclature database: 2.5.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.15
            BRENDA, the Enzyme Database: 2.5.1.15
            SCOP (Structural Classification of Proteins): 2.5.1.15
///
ENTRY       EC 2.5.1.16
NAME        Spermidine synthase
            Aminopropyltransferase
            Putrescine aminopropyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosylmethioninamine:putrescine 3-aminopropyltransferase
REACTION    S-Adenosylmethioninamine + Putrescine = 5'-Methylthioadenosine +
            Spermidine
SUBSTRATE   S-Adenosylmethioninamine
            Putrescine
PRODUCT     5'-Methylthioadenosine
            Spermidine
COMMENT     This enzyme is not identical with EC 2.5.1.22. The mammalian
            enzyme is highly specific but the bacterial enzyme can use other
            acceptors and can synthesize spermine.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       ECO: b0121(speE)
            ECE: Z0131(speE)
            ECS: ECs0125
            YPE: YPO3411(speE)
            XFA: XF0143
            PAE: PA1687(speE)
            BUC: BU209(speE)
            HPY: HP0832(speE)
            HPJ: jhp0771
            BSU: BG12460(speE)
            BHA: BH3811
            SPN: SP0918
            SPR: spr0819(speE)
            CAC: CAC2602
            MTU: Rv2601(speE)
            MTC: MT2675
            AAE: aq_062(speE)
            TMA: TM0654
            MJA: MJ0313
            AFU: AF2334(speE)
            TAC: Ta0355
            TVO: TVG0404401
            PHO: PH0211
            PAB: PAB2221(speE)
            APE: APE0767
            SSO: SSO0757
            STO: ST0346
            SCE: YPR069C(SPE3)
            SPO: SPBC12C2.07C(spbc12c2.07c)
            DME: CG8327
            HSA: 6723(SRM)
MOTIF       PS: PS01330  V-[LA]-[LIV](2)-G-G-G-x-G-x(2)-[LIV]-x-E
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.16
            ExPASy - ENZYME nomenclature database: 2.5.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.16
            BRENDA, the Enzyme Database: 2.5.1.16
///
ENTRY       EC 2.5.1.17
NAME        Cob(I)alamin adenosyltransferase
            Aquacob(I)alamin adenosyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     ATP:cob(I)alamin Co-beta-adenosyltransferase
REACTION    ATP + Cob(I)alamin + H2O = Orthophosphate + Pyrophosphate +
            Adenosylcobalamin
SUBSTRATE   ATP
            Cob(I)alamin
            H2O
PRODUCT     Orthophosphate
            Pyrophosphate
            Adenosylcobalamin
COFACTOR    Manganese
COMMENT     Requires Mn2+
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b1270(btuR) b2459
            ECE: Z0886 Z2540(btuR) Z3715
            ECS: ECs0756 ECs1842 ECs3321
            YPE: YPO2214(btuR)
            VCH: VC1040
            PAE: PA1272(cobO)
            MLO: mll1306
            SME: SMc04302(cobO)
            MTU: Rv2849c(cobA)
            MTC: MT2915
            SYN: slr0260(cobA)
            DRA: DRB0008
            TMA: TM1465
            HAL: VNG1574G(cobI)
            TAC: Ta1121
            TVO: TVG1247214
            PHO: PH0075
            PAB: PAB2289
STRUCTURES  PDB: 1G5R  1G64  1G5T  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.17
            ExPASy - ENZYME nomenclature database: 2.5.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.17
            BRENDA, the Enzyme Database: 2.5.1.17
            SCOP (Structural Classification of Proteins): 2.5.1.17
///
ENTRY       EC 2.5.1.18
NAME        Glutathione transferase
            Glutathione S-transferase
            Glutathione S-alkyltransferase
            Glutathione S-aryltransferase
            S-(Hydroxylalkyl)-glutathione liase
            Glutathione S-aralkyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     RX:glutathione R-transferase
REACTION    RX + Glutathione = HX + R-S-Glutathione
SUBSTRATE   RX
            Glutathione
PRODUCT     HX
            R-S-Glutathione
INHIBITOR   S-Hexyl-glutathione
COMMENT     A group of enzymes of broad specificity. R (RX) may be an
            aliphatic, aromatic or heterocyclic group; X may be a sulfate,
            nitrile or halide group. Also catalyses the addition of aliphatic
            epoxides and arene oxides to glutathione; the reduction of polyol
            nitrate by glutathione to polyol and nitrile; certain
            isomerization reactions and disulfide interchange.
            Inhibited by S-hexyl-GSH ( J.Biol.Chem. 268, 19188-19191 (1993) ).
PATHWAY     PATH: MAP00480  Glutathione metabolism
GENES       ECO: b1635(gst)
            ECE: Z2647(gst)
            ECS: ECs2344
            YPE: YPO2367(gst)
            HIN: HI0111(gst)
            XFA: XF1210
            RCO: RC0782
            MLO: mll3731 mlr0981 mlr3345
            SME: SMa1497(gst12) SMa2115(gst13) SMa2319(gst14) SMb20005(gst15)
                 SMb21449(gst12) SMc00036(gst1) SMc00097(gst2) SMc00383(gst3)
                 SMc00407(gst4) SMc00916(gst11) SMc01238(gst5) SMc01443(gst6)
                 SMc02390(gst7) SMc03206(maiA) SMc04141(gst9) SMc04321(gst10)
            CCR: CC2973
            SYN: sll0067(gst) sll1545(gst1)
            ATH: At1g02930(F22D16.7) At2g02380(T16F16.17) At2g02390(T16F16.18)
                 At2g29450(F16P2.17) At2g30870(F7F1.8) At4g02520(T10P11.18)
            CEL: F11G11.1 F11G11.2 F11G11.3 F35E8.8 F37F2.3 R03D7.6 R07B1.4
                 ZK546.11 gst-1
            DME: CG10045(GstD1) CG11512(GstD23) CG12242(GstD24) CG12628 CG1742
                 CG17530 CG4181(GstD21) CG4371(GstD26) CG4381 CG4421(GstD27)
                 CG4423(GstD25) CG5164(Gst3) CG8938(Gst2)
            MMU: 95857(Gsta)
            HSA: 2938(GSTA1) 2939(GSTA2) 2940(GSTA3) 2941(GSTA4) 2944(GSTM1)
                 2946(GSTM2) 2947(GSTM3) 2948(GSTM4) 2949(GSTM5) 2950(GSTP1)
                 2952(GSTT1) 2953(GSTT2) 2954(GSTZ1) 4257(MGST1) 4258(MGST2)
                 4259(MGST3) 51064(LOC51064) 9446(GSTTLp28)
DISEASE     MIM: 134660  Glutathione S-transferase pi
            MIM: 138330  Microsomal glutathione S-transferase 1
            MIM: 138333  Glutathione S-transferase M4
            MIM: 138350  Glutathione S-transferase M1
            MIM: 138359  Glutathione S-transferase A1
            MIM: 138360  Glutathione S-transferase A2
            MIM: 138380  Glutathione S-transferase M2, muscle
            MIM: 138385  Glutathione S-transferase M5
            MIM: 138390  Glutathione S-transferase M3, brain
            MIM: 600436  Glutathione S-transferase, theta-1
            MIM: 600437  Glutathione S-transferase theta-2
MOTIF       PS: PS01297  G-x(3)-F-E-R-V-[FY]-x-A-[NQ]-x-N-C
STRUCTURES  PDB: 1GNE  1GNW  1GSB  1GSC  1GSD  1GSE  1GSF  1GUL  1GSU  1GSY  
                 1GTA  1GTB  1GTI  1GTU  1GSQ  1GSS  1GUH  1GUM  1HNA  1HNB  
                 1HNC  1LJR  1PGT  1PMT  20GS  21GS  22GS  2FHE  2GLR  1EV9  
                 1GLP  1GUK  1FW1  1GLQ  2GSS  2PGT  2PMT  3FYG  1EOH  3GST  
                 3GTU  3LJR  3PGT  4GSS  4GST  4GTU  4PGT  5FWG  5GSS  5GST  
                 6GSS  6GST  6GSU  6GSV  6GSW  6GSX  6GSY  7GSS  8GSS  9GSS  
                 1EOG  1E6B  11GS  10GS  1FHE  1DUG  1C72  2GSQ  1EV4  2GST  
                 1F3B  1F3A  2GTU  1F2E  1B48  1BAY  2LJR  1AXD  1AW9  1AQX  
                 1AQW  1AQV  1AGS  1A0F  19GS  3GSS  18GS  17GS  16GS  14GS  
                 13GS  2GSR  12GS  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.18
            ExPASy - ENZYME nomenclature database: 2.5.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.18
            BRENDA, the Enzyme Database: 2.5.1.18
            SCOP (Structural Classification of Proteins): 2.5.1.18
///
ENTRY       EC 2.5.1.19
NAME        3-Phosphoshikimate 1-carboxyvinyltransferase
            5-Enolpyruvylshikimate-3-phosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-
            transferase
REACTION    Phosphoenolpyruvate + Shikimate 3-phosphate = Orthophosphate +
            5-O-(1-Carboxyvinyl)-3-phosphoshikimate
SUBSTRATE   Phosphoenolpyruvate
            Shikimate 3-phosphate
PRODUCT     Orthophosphate
            5-O-(1-Carboxyvinyl)-3-phosphoshikimate
INHIBITOR   Glyphosate
COMMENT     Shikimate is numbered so that the double bond is between C-1 and
            C-2, but some earlier papers numbered the ring in the reverse
            direction
            3D-structure of the enzyme from E.coli was determined at 3-A
            resolution (Stallings W.C.,et.al. Proc.Natl.Acad.Sci.USA (1991)
            88:5046-5050
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b0908(aroA)
            ECE: Z1254(aroA)
            ECS: ECs0991
            YPE: YPO1390(aroA)
            HIN: HI1589(aroA)
            PMU: PM0839(aroA)
            XFA: XF2324
            VCH: VC1732
            PAE: PA3164
            BUC: BU311(aroA)
            NME: NMB1432
            NMA: NMA1644(aroA)
            HPY: HP0401(aroA)
            HPJ: jhp0980
            CJE: Cj0895c(aroA)
            MLO: mll5213
            SME: SMc00333(aroA)
            CCR: CC3589
            BSU: BG10294(aroE)
            BHA: BH1667(aroE) BH2713
            SAU: SA1297(aroA)
            SAV: SAV1453(aroA)
            LLA: L0057(aroA)
            SPY: SPy1352(aroA)
            SPN: SP1371
            SPR: spr1229(aroA)
            CAC: CAC0895(aroA)
            MTU: Rv3227(aroA)
            MTC: MT3324
            MLE: ML0792(aroA)
            CTR: CT366
            CMU: TC0645
            CPN: CPn1039
            CPA: CP0813
            CPJ: aroA
            SYN: slr0444(aroA)
            DRA: DR1096
            AAE: aq_1536(aroA)
            TMA: TM0345
            MJA: MJ0502(aroA)
            MTH: MTH766
            AFU: AF1497(aroA)
            HAL: VNG1232G(psc)
            TAC: Ta0282
            TVO: TVG1387115
            PAB: PAB0306(aroA)
            APE: APE0569 APE1404
            SSO: SSO0309(aroA)
            SCE: YDR127W(ARO1)
            ATH: At2g45300(F4L23.42)
MOTIF       PS: PS00104  [LIVF]-x(2)-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-x-R-
                         x-[LIVMFYAT]-x-[GSTAP]
            PS: PS00885  [KR]-x-[KH]-E-[CST]-[DNE]-R-[LIVM]-x-[GSTAV]-[LIVMCT]-
                         x(3)-[LIVMF]-x(2)-[LIVMFCGAN]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-
                         H-[DN]
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMFG]
STRUCTURES  PDB: 1G6T  1G6S  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.19
            ExPASy - ENZYME nomenclature database: 2.5.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.19
            BRENDA, the Enzyme Database: 2.5.1.19
            SCOP (Structural Classification of Proteins): 2.5.1.19
///
ENTRY       EC 2.5.1.20
NAME        Rubber cis-polyprenylcistransferase
            Rubber allyltransferase
            Rubber transferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     poly-cis-Polyprenyl-diphosphate:isopentenyl-diphosphate
            $ polyprenylcistransferase
REACTION    poly-cis-Polyprenyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate +
            a poly-cis-Polyprenyl diphosphate longer by one C5 unit
SUBSTRATE   poly-cis-Polyprenyl diphosphate
            Isopentenyl diphosphate
            Rubber particle
PRODUCT     Pyrophosphate
            poly-cis-Polyprenyl diphosphate longer by one C5 unit
COMMENT     Rubber particles act as acceptor.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.20
            ExPASy - ENZYME nomenclature database: 2.5.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.20
            BRENDA, the Enzyme Database: 2.5.1.20
///
ENTRY       EC 2.5.1.21
NAME        Farnesyl-diphosphate farnesyltransferase
            Farnesyltransferase
            Presqualene-diphosphate synthase
            Squalene synthetase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase
REACTION    2 Farnesyl diphosphate = Pyrophosphate +
            Presqualene diphosphate;
            Presqualene diphosphate = Pyrophosphate +
            Cyclopropylcarbinyl cation;
            Cyclopropylcarbinyl cation + NADPH = Squalene + NADP+
SUBSTRATE   Farnesyl diphosphate
            Presqualene diphosphate
            NADPH
            Cyclopropylcarbinyl cation
PRODUCT     Pyrophosphate
            Presqualene diphosphate
            Cyclopropylcarbinyl cation
            NADP+
            Squalene
INHIBITOR   alpha-Phosphono sulfonate triacid
COMMENT     The polymeric form of the enzyme also catalyses the reduction of
            presqualene diphosphate by NADPH to squalene via cationic 
            intermediate, cyclopropylcarbinyl cation, which was trapped as
            the corresponding alcohol, rillingol, by using a dihydro analog of 
            NADPH as the reducing agent (J.Am.Chem.Sco., 118, 13089 (1996)).
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       SCE: YHR190W(ERG9)
            ATH: At4g34640(T4L20.220)
            MMU: 102706(Fdft1)
            HSA: 2222(FDFT1)
DISEASE     MIM: 184420  Farnesyl-diphosphate farnesyltransferase 1 (squalene
                         synthase)
MOTIF       PS: PS01044  Y-[CSAM]-x(2)-[VSG]-A-[GSA]-[LIVAT]-[IV]-G-x(2)-[LMSC]-
                         x(2)-[LIV]
            PS: PS01045  [LIVM]-G-x(3)-Q-x(2,3)-N-[IF]-x-R-D-[LIVMFY]-x(2)-[DE]-
                         x(4,7)-R-x-[FY]-x-P
STRUCTURES  PDB: 1EZF  1D8E  1D8D  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.21
            ExPASy - ENZYME nomenclature database: 2.5.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.21
            BRENDA, the Enzyme Database: 2.5.1.21
            SCOP (Structural Classification of Proteins): 2.5.1.21
///
ENTRY       EC 2.5.1.22
NAME        Spermine synthase
            Spermidine aminopropyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosylmethioninamine:spermidine 3-aminopropyltransferase
REACTION    S-Adenosylmethioninamine + Spermidine = 5'-Methylthioadenosine +
            Spermine
SUBSTRATE   S-Adenosylmethioninamine
            Spermidine
PRODUCT     5'-Methylthioadenosine
            Spermine
COMMENT     This enzyme is not identical with EC 2.5.1.16 or 2.5.1.23.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       SCE: YLR146C(SPE4)
            DME: CG4300 CG4300_1
            HSA: 6611(SMS)
MOTIF       PS: PS01330  V-[LA]-[LIV](2)-G-G-G-x-G-x(2)-[LIV]-x-E
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.22
            ExPASy - ENZYME nomenclature database: 2.5.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.22
            BRENDA, the Enzyme Database: 2.5.1.22
///
ENTRY       EC 2.5.1.23
NAME        sym-Norspermidine synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosylmethioninamine:propane-1,3-diamine
            $ 3-aminopropyltransferase
REACTION    S-Adenosylmethioninamine + Propane-1,3-diamine =
            5'-Methylthioadenosine + Bis(3-aminopropyl)amine
SUBSTRATE   S-Adenosylmethioninamine
            Propane-1,3-diamine
PRODUCT     5'-Methylthioadenosine
            Bis(3-aminopropyl)amine
COMMENT     This enzyme is not identical with EC 2.5.1.16 or 2.5.1.22.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.23
            ExPASy - ENZYME nomenclature database: 2.5.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.23
            BRENDA, the Enzyme Database: 2.5.1.23
///
ENTRY       EC 2.5.1.24
NAME        Discadenine synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosyl-L-methionine:N6-(delta2-isopentenyl)-adenine
            $ 3-(3-amino-3-carboxypropyl)-transferase
REACTION    S-Adenosyl-L-methionine + N6-(delta2-Isopentenyl)-adenine =
            5'-Methylthioadenosine + Discadenine
SUBSTRATE   S-Adenosyl-L-methionine
            N6-(delta2-Isopentenyl)-adenine
PRODUCT     5'-Methylthioadenosine
            Discadenine
COMMENT     Discadenine is 3-(3-amino-3-carboxypropyl)-N6-(delta2-
            isopentenyl)-adenine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.24
            ExPASy - ENZYME nomenclature database: 2.5.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.24
            BRENDA, the Enzyme Database: 2.5.1.24
///
ENTRY       EC 2.5.1.25
NAME        tRNA-uridine aminocarboxypropyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-
            $carboxypropyl)transferase
REACTION    S-Adenosyl-L-methionine + tRNA uridine = 5'-Methylthioadenosine +
            tRNA 3-(3-amino-3-carboxypropyl)-uridine
SUBSTRATE   S-Adenosyl-L-methionine
            tRNA uridine
PRODUCT     5'-Methylthioadenosine
            tRNA 3-(3-amino-3-carboxypropyl)-uridine
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.25
            ExPASy - ENZYME nomenclature database: 2.5.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.25
            BRENDA, the Enzyme Database: 2.5.1.25
///
ENTRY       EC 2.5.1.26
NAME        Alkylglycerone-phosphate synthase
            Alkyldihydroxyacetonephosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     1-Acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-
            $2-oxopropanyltransferase
REACTION    1-Acyl-glycerone 3-phosphate + a Long-chain alcohol =
            an Alkyl-glycerone 3-phosphate + a Long-chain acid anion
SUBSTRATE   1-Acyl-glycerone 3-phosphate
            Long-chain alcohol
PRODUCT     Alkyl-glycerone 3-phosphate
            Long-chain acid anion
COMMENT     The ester-linked fatty acid of the substrate is cleaved and
            replaced by a long-chain alcohol in an ether linkage.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       MTU: Rv2251
            AFU: AF0868
            APE: APE0308
            SSO: SSO1531
            DME: CG10253
            HSA: 8540(AGPS)
DISEASE     MIM: 603051  Alkylglycerone-phosphate synthase
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.26
            ExPASy - ENZYME nomenclature database: 2.5.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.26
            BRENDA, the Enzyme Database: 2.5.1.26
///
ENTRY       EC 2.5.1.27
NAME        Adenylate isopentenyltransferase
            Cytokinin synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     2-Isopentenyl-diphosphate:AMP delta2-isopentenyltransferase
REACTION    delta2-Isopentenyl diphosphate + AMP = Pyrophosphate +
            N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
SUBSTRATE   delta2-Isopentenyl diphosphate
            AMP
PRODUCT     Pyrophosphate
            N6-(delta2-Isopentenyl)-adenosine 5'-monophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.27
            ExPASy - ENZYME nomenclature database: 2.5.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.27
            BRENDA, the Enzyme Database: 2.5.1.27
///
ENTRY       EC 2.5.1.28
NAME        Dimethylallylcistransferase
            Neryl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Dimethylallyl-diphosphate:isopentenyl-diphosphate
            $ dimethylallylcistransferase
REACTION    Dimethylallyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + Neryl diphosphate
SUBSTRATE   Dimethylallyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            Neryl diphosphate
COMMENT     This enzyme will not use larger prenyl diphosphates as efficient
            donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.28
            ExPASy - ENZYME nomenclature database: 2.5.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.28
            BRENDA, the Enzyme Database: 2.5.1.28
///
ENTRY       EC 2.5.1.29
NAME        Farnesyltranstransferase
            Geranylgeranyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     trans,trans-Farnesyl-diphosphate:isopentenyl-diphosphate
            $ farnesyltranstransferase
REACTION    trans,trans-Farnesyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + Geranylgeranyl diphosphate
SUBSTRATE   trans,trans-Farnesyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            Geranylgeranyl diphosphate
COMMENT     Some forms of this enzyme will also use geranyl diphosphate and
            dimethylallyl diphosphate as donors; it will not use larger
            prenyl diphosphate as efficient donors.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       MTU: Rv3398c(idsA)
            MTC: MT3506
            SYN: slr0739(crtE)
            SSO: SSO0061(gdS-1)
            ATH: At4g36810(AP22.99)
            DME: CG8593
            HSA: 9453(GGPS1)
MOTIF       PS: PS00444  [LIVMFY]-G-x(2)-[FYL]-Q-[LIVM]-x-D-D-[LIVMFY]-x-[DNG]
            PS: PS00723  [LIVM](2)-x-D-D-x(2,4)-D-x(4)-R-R-[GH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.29
            ExPASy - ENZYME nomenclature database: 2.5.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.29
            BRENDA, the Enzyme Database: 2.5.1.29
///
ENTRY       EC 2.5.1.30
NAME        trans-Hexaprenyltranstransferase
            all-trans-Heptaprenyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     all-trans-Hexaprenyl-diphosphate:isopentenyl-diphosphate
            $ hexaprenyltranstransferase
REACTION    all-trans-Hexaprenyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + all-trans-Heptaprenyl diphosphate
SUBSTRATE   all-trans-Hexaprenyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            all-trans-Heptaprenyl diphosphate
COMMENT     This enzyme will also use trans,trans-farnesyl diphosphate and
            all-trans-prenyl diphosphates of intermediate size as donors, but
            not dimethylallyl diphosphate.
GENES       BSU: BG10279(hepB) BG10281(hepA)
            BHA: BH1648(gerCA) BH1653(gerCC)
            SAU: SA1302(gerCC)
            SAV: SAV1459(gerCC)
            MTU: Rv0562(grcC1) Rv0989c(grcC2)
            MTC: MT0588 MT1018
            MLE: ML2277
MOTIF       PS: PS00444  [LIVMFY]-G-x(2)-[FYL]-Q-[LIVM]-x-D-D-[LIVMFY]-x-[DNG]
            PS: PS00723  [LIVM](2)-x-D-D-x(2,4)-D-x(4)-R-R-[GH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.30
            ExPASy - ENZYME nomenclature database: 2.5.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.30
            BRENDA, the Enzyme Database: 2.5.1.30
///
ENTRY       EC 2.5.1.31
NAME        di-trans,poly-cis-Decaprenylcistransferase
            di-trans,poly-cis-Undecaprenyl-diphosphate synthase
            Undecaprenyl-diphosphate synthase
            Bactoprenyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     di-trans,poly-cis-Decaprenyl-diphosphate:isopentenyl-diphosphate
            $ undecaprenylcistransferase
REACTION    di-trans,poly-cis-Decaprenyl diphosphate +
            Isopentenyl diphosphate = Pyrophosphate +
            di-trans,poly-cis-Undecaprenyl diphosphate
SUBSTRATE   di-trans,poly-cis-Decaprenyl diphosphate
            Isopentenyl diphosphate
PRODUCT     Pyrophosphate
            di-trans,poly-cis-Undecaprenyl diphosphate
COMMENT     This enzyme will also use trans,trans-farnesyl diphosphate and
            di-trans,poly-cis-prenyl diphosphate of intermediate size as
            donors. The two trans- bonds in the substrate and product are
            those furthest from the diphosphate group.
GENES       ECO: b0174(yaeS)
            ECE: Z0185(yaeS)
            ECS: ECs0176
            YPE: YPO1049(uppS)
            HIN: HI0920
            PMU: PM1989
            XFA: XF1050
            VCH: VC2256
            PAE: PA3652(uppS)
            BUC: BU236(uppS)
            NME: NMB0186
            NMA: NMA0081(uppS)
            HPY: HP1221
            HPJ: jhp1142
            CJE: Cj0824(uppS)
            RPR: RP425
            RCO: RC0590
            MLO: mll0640
            SME: SMc02097(uppS)
            CCR: CC1919
            BSU: BG13408(uppS)
            BHA: BH2423(uppS)
            SAU: SA1103(uppS)
            SAV: SAV1248(uppS)
            LLA: L183602(uppS)
            SPY: SPy1965(uppS)
            SPN: SP0261
            SPR: spr0240(uppS)
            CAC: CAC1432 CAC1791
            MTU: Rv2361c
            MTC: MT2430
            MLE: ML0634
            CTR: CT450
            CMU: TC0735
            CPN: CPn0566
            CPA: CP0183
            CPJ: yaeS
            BBU: BB0120
            TPA: TP0603
            SYN: sll0506
            DRA: DR2447
            AAE: aq_1248
            TMA: TM1398
            MJA: MJ1372
            MTH: MTH232
            AFU: AF1219
            HAL: VNG1779C
            TAC: Ta0546
            TVO: TVG0591988
            PHO: PH1590
            PAB: PAB0394(hypoth)
            SSO: SSO0163
            STO: ST0189
MOTIF       PS: PS01066  [DEH]-[LIVMF](3)-R-[ST]-[SGA]-G-x(2)-R-x-S-x-[FY]-
                         [LMF]-[LIP]-[YW]
STRUCTURES  PDB: 1JP3  1F75  
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.31
            ExPASy - ENZYME nomenclature database: 2.5.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.31
            BRENDA, the Enzyme Database: 2.5.1.31
///
ENTRY       EC 2.5.1.32
NAME        Geranylgeranyl-diphosphate geranylgeranyltransferase
            Prephytoene-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Geranylgeranyl-diphosphate:geranylgeranyl-diphosphate
            geranylgeranyltransferase
REACTION    2 Geranylgeranyl diphosphate = Pyrophosphate +
            Prephytoene diphosphate
SUBSTRATE   Geranylgeranyl diphosphate
PRODUCT     Pyrophosphate
            Prephytoene diphosphate
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.32
            ExPASy - ENZYME nomenclature database: 2.5.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.32
            BRENDA, the Enzyme Database: 2.5.1.32
///
ENTRY       EC 2.5.1.33
NAME        trans-Pentaprenyltranstransferase
            all-trans-Hexaprenyl-diphosphate synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     all-trans-Pentaprenyl-diphosphate:isopentenyl-diphosphate
            pentaprenyltranstransferase
REACTION    all-trans-Pentaprenyl diphosphate + Isopentenyl diphosphate =
            Pyrophosphate + all-trans-Hexaprenyl diphosphate
SUBSTRATE   all-trans-Pentaprenyl diphosphate
            Isopentenyl diphosphate
            trans,trans-Farnesyl diphosphate
            all-trans-Geranylgeranyl diphosphate
PRODUCT     Pyrophosphate
            all-trans-Hexaprenyl diphosphate
COMMENT     This enzyme will also use trans,trans-farnesyl diphosphate
            and all-trans-geranylgeranyl diphosphate as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.33
            ExPASy - ENZYME nomenclature database: 2.5.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.33
            BRENDA, the Enzyme Database: 2.5.1.33
///
ENTRY       EC 2.5.1.34
NAME        Tryptophan dimethylallyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase
REACTION    Dimethylallyl diphosphate + L-Tryptophan = Pyrophosphate +
            4-(3-Methylbut-2-enyl)-L-tryptophan
SUBSTRATE   Dimethylallyl diphosphate
            L-Tryptophan
PRODUCT     Pyrophosphate
            4-(3-Methylbut-2-enyl)-L-tryptophan
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.34
            ExPASy - ENZYME nomenclature database: 2.5.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.34
            BRENDA, the Enzyme Database: 2.5.1.34
///
ENTRY       EC 2.5.1.35
NAME        Aspulvinone dimethylallyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase
REACTION    2 Dimethylallyl diphosphate + Aspulvinone E = 2 Pyrophosphate +
            Aspulvinone H
SUBSTRATE   Dimethylallyl diphosphate
            Aspulvinone E
            Aspulvinone G
PRODUCT     Pyrophosphate
            Aspulvinone H
COMMENT     This enzyme will also usr as acceptor aspulvinone G, a
            hydroxylated derivative of the complex phenolic pigment
            aspulvinone E.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.35
            ExPASy - ENZYME nomenclature database: 2.5.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.35
            BRENDA, the Enzyme Database: 2.5.1.35
///
ENTRY       EC 2.5.1.36
NAME        Trihydroxypterocarpan dimethylallyltransferase
            Glyceollin synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan
            $ dimethyltransferase
REACTION    Dimethylallyl diphosphate +
            (6aS,11aS)-3,6a,9-Trihydroxypterocarpan = Pyrophosphate +
            Glyceollin
SUBSTRATE   Dimethylallyl diphosphate
            (6aS,11aS)-3,6a,9-Trihydroxypterocarpan
PRODUCT     Pyrophosphate
            Glyceollin
COMMENT     Part of the glyceollin biosynthesis system in soybean.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.36
            ExPASy - ENZYME nomenclature database: 2.5.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.36
            BRENDA, the Enzyme Database: 2.5.1.36
///
ENTRY       EC 2.5.1.37
NAME        Leukotriene-C4 synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate:
            $glutathione leukotriene-transferase (epoxide-ring-opening)
REACTION    Leukotriene A4 + Glutathione = Leukotriene C4 + H2O
SUBSTRATE   Leukotriene A4
            Glutathione
PRODUCT     Leukotriene C4
            H2O
COMMENT     Not identical with EC 2.5.1.8.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: 4056(LTC4S)
MOTIF       PS: PS01297  G-x(3)-F-E-R-V-[FY]-x-A-[NQ]-x-N-C
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.37
            ExPASy - ENZYME nomenclature database: 2.5.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.37
            BRENDA, the Enzyme Database: 2.5.1.37
///
ENTRY       EC 2.5.1.38
NAME        Isonocardicin synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     S-Adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyl
            $transferase
REACTION    S-Adenosyl-L-methionine + Nocardin E = 5'-Methylthioadenosine +
            Isonocardicin A
SUBSTRATE   S-Adenosyl-L-methionine
            Nocardin E
PRODUCT     5'-Methylthioadenosine
            Isonocardicin A
COMMENT     Involved in the biosynthesis of the beta-lactam antibiotic
            nocardicin A.
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.38
            ExPASy - ENZYME nomenclature database: 2.5.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.38
            BRENDA, the Enzyme Database: 2.5.1.38
///
ENTRY       EC 2.5.1.39
NAME        4-Hydroxybenzoate nonaprenyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Solanesyl-pyrophosphate:4-hydroxybenzoate nonaprenyltransferase
REACTION    Solanesyl pyrophosphate + 4-Hydroxybenzoate = Pyrophosphate +
            Nonaprenyl-4-hydroxybenzoate
SUBSTRATE   Solanesyl pyrophosphate
            4-Hydroxybenzoate
PRODUCT     Pyrophosphate
            Nonaprenyl-4-hydroxybenzoate
COMMENT     Involved in the biosynthesis of ubiquinone.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.39
            ExPASy - ENZYME nomenclature database: 2.5.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.39
            BRENDA, the Enzyme Database: 2.5.1.39
///
ENTRY       EC 2.5.1.40
NAME        Aristolochene synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     trans,trans-Farnesyl-diphosphate farnesyltransferase (bicyclizing)
REACTION    trans,trans-Farnesyl diphosphate = Pyrophosphate + Aristolochene
SUBSTRATE   trans,trans-Farnesyl diphosphate
PRODUCT     Pyrophosphate
            Aristolochene
COMMENT     The initial internal transfer of the farnesyl group to the C-10
            position preduces the monocyclic intermediate germacrene A;
            further cyclization and methyl transfer converts the intermediate
            into aristolochene.
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.40
            ExPASy - ENZYME nomenclature database: 2.5.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.40
            BRENDA, the Enzyme Database: 2.5.1.40
///
ENTRY       EC 2.5.1.41
NAME        Phosphoglycerol geranylgeranyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Geranylgeranyl diphosphate:sn-glyceryl phosphate
            $ geranylgeranyltransferase
REACTION    Geranylgeranyl diphosphate + sn-Glyceryl phosphate =
            Pyrophosphate + sn-3-O-(Geranylgeranyl)glycerol 1-phosphate
SUBSTRATE   Geranylgeranyl diphosphate
            sn-Glyceryl phosphate
PRODUCT     Pyrophosphate
            sn-3-O-(Geranylgeranyl)glycerol 1-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.41
            ExPASy - ENZYME nomenclature database: 2.5.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.41
            BRENDA, the Enzyme Database: 2.5.1.41
///
ENTRY       EC 2.5.1.42
NAME        Geranylgeranylglycerol-phosphate geranylgeranyltransferase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
SYSNAME     Geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol
            $ 1-phosphate geranylgeranyltransferase
REACTION    Geranylgeranyl diphosphate +
            sn-3-O-(Geranylgeranyl)glycerol 1-phosphate = Pyrophosphate +
            2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
SUBSTRATE   Geranylgeranyl diphosphate
            sn-3-O-(Geranylgeranyl)glycerol 1-phosphate
PRODUCT     Pyrophosphate
            2,3-Bis-O-(geranylgeranyl)glycerol 1-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.42
            ExPASy - ENZYME nomenclature database: 2.5.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.42
            BRENDA, the Enzyme Database: 2.5.1.42
///
ENTRY       EC 2.5.1.43
NAME        Nicotianamine synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
            Transferring alkyl or aryl groups either substituted or
            unsubstituted
REACTION    3 S-Adenosyl-L-methionine = 3 5-Methylthioadenosine + Nicotianamine
SUBSTRATE   S-Adenosyl-L-methionine
PRODUCT     5-Methylthioadenosine
            Nicotianamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.43
            ExPASy - ENZYME nomenclature database: 2.5.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.43
///
ENTRY       EC 2.5.1.44
NAME        Homospermidine synthase
CLASS       Transferases
            Transferring alkyl or aryl groups, other than methyl groups
            Transferring alkyl or aryl groups either substituted or
            unsubstituted
REACTION    2 Putrescine = sym-Homospermidine + NH3;
            Putrescine + Spermidine = sym-Homospermidine + Propane-1,3-diamine
SUBSTRATE   Putrescine
            Spermidine
PRODUCT     sym-Homospermidine
            NH3
            Propane-1,3-diamine
COFACTOR    NAD
COMMENT     NAD+ functions catalytically.
            In the presence of putrescine, spermidine can function as a donor
            of the aminobutyl group, in which case propanediamine is released
            instead of ammonia,
DBLINKS     IUBMB Enzyme Nomenclature: 2.5.1.44
            ExPASy - ENZYME nomenclature database: 2.5.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.5.1.44
///
ENTRY       EC 2.6.1.1
NAME        Aspartate transaminase
            Glutamic-oxaloacetic transaminase
            Glutamic-aspartic transaminase
            Transaminase A
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Aspartate:2-oxoglutarate aminotransferase
REACTION    L-Aspartate + 2-Oxoglutarate = Oxaloacetate + L-Glutamate
SUBSTRATE   L-Aspartate
            L-Tyrosine
            L-Phenylalanine
            L-Tryptophan
            2-Oxoglutarate
PRODUCT     Oxaloacetate
            L-Glutamate
            3-(4-Hydroxyphenyl)pyruvate
            Phenylpyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts also on L-tyrosine, L-phenyl-
            alanine and L-tryptophan. This acticity can be formed from EC
            2.6.1.57 by controlled proteolysis.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00710  Carbon fixation
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       ECO: b0600(ybdL) b0928(aspC) b2290
            ECE: Z0743(ybdL) Z1275(aspC) Z3551
            ECS: ECs0639 ECs1011 ECs3174
            YPE: YPO1410(aspC) YPO2558(aat)
            HIN: HI0286(aspC) HI1617(aspC)
            PMU: PM0052 PM0621(aspC)
            XFA: XF2396
            VCH: VC1293 VC1977 VCA0513
            PAE: PA0870(phhC) PA2828 PA3798 PA4722 PA4976(aspC)
            NME: NMB0540 NMB1473
            NMA: NMA0719(aspC) NMA1684
            HPY: HP0672(aspB)
            HPJ: jhp0615
            CJE: Cj0762c(aspB)
            RPR: RP091(aatA)
            RCO: RC0120(aatA)
            MLO: mlr0210 mlr1282 mlr2541 mlr2987 mlr4213 mlr5693 mlr5883
                 mlr9116 mlr9118
            SME: SMc01578(aatA) SMc04386(aatB)
            CCR: CC1534 CC2455
            BSU: BG10631(ywfG) BG11513(aspB) BG13024(yhdR)
            BHA: BH1695(aspB) BH2195
            SAU: SA1749
            SAV: SAV1921
            LLA: L0098(aspB) L162604(aspC)
            SPY: SPy0650(aspC) SPy1779
            SPN: SP1544 SP1994
            SPR: spr0035(aspC) spr1399(aspB) spr1808(aspC)
            CAC: CAC1001 CAC1819(aspB) CAC2832
            MTU: Rv0337c(aspC) Rv1178 Rv3565(aspB)
            MTC: MT0351 MT1215
            MLE: ML1488 ML2502
            CTR: CT390 CT637
            CMU: TC0005 TC0669
            CPN: CPn0495 CPn0740
            CPA: CP0005 CP0259
            CPJ: aspC tyrB
            TPA: TP0223
            SYN: sll0402(aspC) slr0036(aspC)
            DRA: DR0623
            AAE: aq_1969(aspC1) aq_421(aspC3)
            TMA: TM1255 TM1698
            MJA: MJ0001 MJ0684(aspB2) MJ1391 MJ1479
            MTH: MTH1694 MTH1894 MTH52
            AFU: AF1623(aspB-3) AF2129(aspB-2) AF2366(aspB-1)
            HAL: VNG0502G(aspB1) VNG0629G(aspB2) VNG1121G(aspC2)
            TAC: Ta0529 Ta0765
            TVO: TVG0882679 TVG1059341
            PHO: PH0771 PH1322 PH1371
            PAB: PAB0525(aspC) PAB1523(aspB-2) PAB1810
            APE: APE0674 APE2248
            SSO: SSO0104(aspB-1) SSO0897(aspB-2) SSO1177(aspB-3)
                 SSO3245(aspB-4)
            STO: ST1225
            SCE: YKL106W(AAT1) YLR027C(AAT2)
            SPO: SPAC10F6.13C(spac10f6.13c) SPBC725.01(spbc725.01)
            ATH: At1g62790(F23N19.16) At1g62800(F23N19.17) At2g22250(T26C19.9)
                 At2g30970(F7F1.18) At4g31990(F10N7.200) At5g11520(F15N18.110)
                 At5g19550(T20D1.70)
            CEL: C14E2.2 C14F11.1 C44E4.3 T01C8.4 T01C8.5
            DME: CG4233 CG8430
            MMU: 95791(Got1) 95792(Got2)
            HSA: 2805(GOT1) 2806(GOT2)
DISEASE     MIM: 138150  Glutamic-oxaloacetic transaminase-2, mitochondrial (EC
                         2.6.1.1)
            MIM: 138180  Glutamic-oxaloacetic transaminase-1, soluble (EC
                         2.6.1.1)
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
STRUCTURES  PDB: 1AAM  1AAT  1AAW  1AHE  1AHF  1AHG  1AHX  1AHY  1AIA  1AIB  
                 1AIC  1AJR  1AJS  1AKA  1AKB  1AKC  1AMA  1AMQ  1AMR  1AMS  
                 1ARG  1ARH  1ARI  1ARS  1ART  1ASA  1ASB  1ASC  1ASD  1ASE  
                 1ASF  1ASG  1ASL  1ASM  1ASN  1B4X  1BJW  1BKG  1BQA  1BQD  
                 1C9C  1CQ6  1CQ7  1CQ8  1CZC  1CZE  1G4V  1G4X  1G7W  1G7X  
                 1GC3  1GC4  1IVR  1MAP  1MAQ  1OXO  1OXP  1QIR  1QIS  1QIT  
                 1SPA  1TAR  1TAS  1TAT  1YAA  1YOO  2AAT  2CST  3AAT  5EAA  
                 7AAT  8AAT  9AAT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.1
            ExPASy - ENZYME nomenclature database: 2.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.1
            BRENDA, the Enzyme Database: 2.6.1.1
            SCOP (Structural Classification of Proteins): 2.6.1.1
///
ENTRY       EC 2.6.1.2
NAME        Alanine transaminase
            Glutamic-pyruvic transaminase
            Glutamic-alanine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:2-oxoglutarate aminotransferase
REACTION    L-Alanine + 2-Oxoglutarate = Pyruvate + L-Glutamate
SUBSTRATE   L-Alanine
            2-Oxoglutarate
            (S)-2-Aminobutanoate
PRODUCT     Pyruvate
            L-Glutamate
            2-Oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. 2-Aminobutanoate acts slowly
            instead of alanine.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00710  Carbon fixation
GENES       SCE: YDR111C(YDR111C) YLR089C
            SPO: SPBC582.08(spbc582.08)
            ATH: At1g17290(T13M22.3) At1g23310(F26F24.16) At1g70580(F5A18.24)
                 At1g72330(T10D10.20)
            CEL: C32F10.8
            DME: CG1640_1
            MMU: 95802(Gpt1)
            HSA: 2875(GPT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.2
            ExPASy - ENZYME nomenclature database: 2.6.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.2
            BRENDA, the Enzyme Database: 2.6.1.2
///
ENTRY       EC 2.6.1.3
NAME        Cysteine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Cysteine:2-oxoglutarate aminotransferase
REACTION    L-Cysteine + 2-Oxoglutarate = Mercaptopyruvate + L-Glutamate
SUBSTRATE   L-Cysteine
            2-Oxoglutarate
PRODUCT     Mercaptopyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00272  Cysteine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.3
            ExPASy - ENZYME nomenclature database: 2.6.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.3
            BRENDA, the Enzyme Database: 2.6.1.3
///
ENTRY       EC 2.6.1.4
NAME        Glycine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Glycine:2-oxoglutarate aminotransferase
REACTION    Glycine + 2-Oxoglutarate = Glyoxylate + L-Glutamate
SUBSTRATE   Glycine
            2-Oxoglutarate
PRODUCT     Glyoxylate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.4
            ExPASy - ENZYME nomenclature database: 2.6.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.4
            BRENDA, the Enzyme Database: 2.6.1.4
///
ENTRY       EC 2.6.1.5
NAME        Tyrosine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Tyrosine:2-oxoglutarate aminotransferase
REACTION    L-Tyrosine + 2-Oxoglutarate = 3-(4-Hydroxyphenyl)pyruvate +
            L-Glutamate
SUBSTRATE   L-Tyrosine
            L-Phenylalanine
            2-Oxoglutarate
PRODUCT     3-(4-Hydroxyphenyl)pyruvate
            Phenylpyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. L-Phenylalanine can act instead
            of L-tyrosine. The mitochondrial enzyme may be identical with
            EC 2.6.1.1 (= Aspartate aminotransferase). The three isoenzymic
            forms are interconverted by EC 3.4.22.4.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       SME: SMc00387(tatA)
            BSU: BG10292(hisC)
            APE: APE2575
            ATH: At2g20610(F23N11.7) At2g24850(F27C12.23) At5g53970(K19P17.14)
            CEL: F42D1.2
            DME: CG1461
            MMU: 98487(Tat)
            HSA: 6898(TAT)
DISEASE     MIM: 276600  Tyrosine aminotransferase, cytosolic
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
STRUCTURES  PDB: 1BW0  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.5
            ExPASy - ENZYME nomenclature database: 2.6.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.5
            UM-BBD (Biocatalysis/Biodegradation Database): 2.6.1.5
            BRENDA, the Enzyme Database: 2.6.1.5
            SCOP (Structural Classification of Proteins): 2.6.1.5
///
ENTRY       EC 2.6.1.6
NAME        Leucine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Leucine:2-oxoglutarate aminotransferase
REACTION    L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate +
            L-Glutamate
SUBSTRATE   L-Leucine
            2-Oxoglutarate
PRODUCT     4-Methyl-2-oxopentanoate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.6
            ExPASy - ENZYME nomenclature database: 2.6.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.6
            BRENDA, the Enzyme Database: 2.6.1.6
///
ENTRY       EC 2.6.1.7
NAME        Kynurenine--oxoglutarate transaminase
            Kynurenine transaminase (cyclizing)
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Kynurenine:2-oxoglutarate aminotransferase
REACTION    L-Kynurenine + 2-Oxoglutarate =
            4-(2-Aminophenyl)-2,4-dioxobutanoate + L-Glutamate
SUBSTRATE   L-Kynurenine
            2-Oxoglutarate
            3-Hydroxykynurenine
PRODUCT     4-(2-Aminophenyl)-2,4-dioxobutanoate
            L-Glutamate
            Xanthurenic acid
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on 3-hydroxykynurenine.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.7
            ExPASy - ENZYME nomenclature database: 2.6.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.7
            BRENDA, the Enzyme Database: 2.6.1.7
///
ENTRY       EC 2.6.1.8
NAME        2,5-Diaminovalerate transaminase
            Diamino-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     2,5-Diaminopentanoate:2-oxoglutarate aminotransferase
REACTION    2,5-Diaminopentanoate + 2-Oxoglutarate =
            5-Amino-2-oxopentanoate + L-Glutamate
SUBSTRATE   2,5-Diaminopentanoate
            2-Oxoglutarate
PRODUCT     5-Amino-2-oxopentanoate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. 2,5-Diaminoglutarate can act
            instead of diaminopentanoate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.8
            ExPASy - ENZYME nomenclature database: 2.6.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.8
            BRENDA, the Enzyme Database: 2.6.1.8
///
ENTRY       EC 2.6.1.9
NAME        Histidinol-phosphate transaminase
            Imidazolylacetolphosphate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Histidinol-phosphate:2-oxoglutarate aminotransferase
REACTION    L-Histidinol phosphate + 2-Oxoglutarate =
            3-(Imidazol-4-yl)-2-oxopropyl phosphate + L-Glutamate
SUBSTRATE   L-Histidinol phosphate
            2-Oxoglutarate
PRODUCT     3-(Imidazol-4-yl)-2-oxopropyl phosphate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2021(hisC)
            ECE: Z3183(hisC)
            ECS: ECs2822
            YPE: YPO1547(hisC)
            HIN: HI0470(hisC) HI1166
            PMU: PM0838(hisH_1) PM1199(hisC)
            XFA: XF2218
            VCH: VC1134
            PAE: PA2531 PA3165(hisC2) PA4447(hisC1)
            BUC: BU101(hisC)
            NME: NMB1582
            NMA: NMA1771(hisC)
            CJE: Cj0317(hisC) Cj1437c
            MLO: mll3536 mll7105 mll7737 mlr5786
            SME: SMc00710(hisC1) SMc03885(hisC2)
            CCR: CC1071 CC2223 CC2534
            BSU: BG10292(hisC)
            BHA: BH1589(cobC) BH1665(hisC)
            SAU: SA0679 SA2469
            SAV: SAV0711(hisC) SAV2662
            LLA: L0065(hisC)
            CAC: CAC1369(hisC) CAC3031(hisC)
            MTU: Rv1600(hisC) Rv2231c(cobC) Rv3772(hisC2)
            MTC: MT1636 MT2290 MT3881
            MLE: ML1258(hisC)
            SYN: sll1713(hisC) sll1958(hisC)
            DRA: DR2461 DRB0011
            AAE: aq_2084(hisC)
            TMA: TM1040
            MJA: MJ0955(hisC)
            MTH: MTH1587
            AFU: AF2002(hisC-1) AF2024(hisC-2)
            HAL: VNG1033G(hisC1) VNG1582G(hisC2)
            TAC: Ta0021
            TVO: TVG0077159
            PHO: PH0377
            PAB: PAB0026(hisC)
            APE: APE2035
            SSO: SSO0448(hisC-like) SSO0592(hisC)
            STO: ST0165
            SCE: YIL116W(HIS5)
            SPO: HIS3(his3)
            ATH: At1g71920(F17M19.7) At5g10330(F18D22.100)
MOTIF       PS: PS00599  T-[LIVMFYW]-[STAG]-K-[SAG]-[LIVMFYWR]-[SAG]-x(2)-[SAG]
STRUCTURES  PDB: 1FG7  1IJI  1GEY  1GEX  1GEW  1FG3  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.9
            ExPASy - ENZYME nomenclature database: 2.6.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.9
            BRENDA, the Enzyme Database: 2.6.1.9
///
ENTRY       EC 2.6.1.10
NAME        Deleted entry
            D-Aspartate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
COMMENT     Deleted entry. Now included with EC 2.6.1.21.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.10
            ExPASy - ENZYME nomenclature database: 2.6.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.10
///
ENTRY       EC 2.6.1.11
NAME        Acetylornithine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     N2-Acetyl-L-ornithine:2-oxoglutarate aminotransferase
REACTION    N2-Acetyl-L-ornithine + 2-Oxoglutarate =
            N-Acetyl-L-glutamate 5-semialdehyde + L-Glutamate
SUBSTRATE   N2-Acetyl-L-ornithine
            2-Oxoglutarate
PRODUCT     N-Acetyl-L-glutamate 5-semialdehyde
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b3359(argD)
            ECE: Z4720(argD)
            ECS: ECs4210
            YPE: YPO0170(argD)
            PMU: PM0344(argD)
            XFA: XF1427
            VCH: VC2618
            PAE: PA0530 PA0895(aruC)
            BUC: BU534(argD)
            NME: NMB1371(argD)
            NMA: NMA1584(argD)
            CJE: Cj0227(argD)
            MLO: mlr5646
            SME: SMc02138(argD)
            CCR: CC0584 CC2243
            BSU: BG10194(argD)
            BHA: BH2897(argD)
            LLA: L0106(argD)
            CAC: CAC2388(argD)
            MTU: Rv1655(argD)
            MTC: MT1693
            MLE: ML1409(argD)
            SYN: slr1022(argD)
            DRA: DR0794
            AAE: aq_023(argD)
            TMA: TM1785(argD)
            MJA: MJ0721(argD)
            MTH: MTH1337
            AFU: AF0080(argD-1) AF1815(argD-2)
            PHO: PH1716
            PAB: PAB2440(argD)
            APE: APE1464
            SSO: SSO0160(argD)
            STO: ST0191
            SCE: YOL140W(ARG8)
            SPO: SPCC777.09C(spcc777.09c) SPO14
            ATH: At1g80600(T21F11.7)
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.11
            ExPASy - ENZYME nomenclature database: 2.6.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.11
            BRENDA, the Enzyme Database: 2.6.1.11
///
ENTRY       EC 2.6.1.12
NAME        Alanine--oxo-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:2-oxo-acid aminotransferase
REACTION    L-Alanine + a 2-Oxo acid = Pyruvate + an L-Amino acid
SUBSTRATE   L-Alanine
            2-Oxo acid
PRODUCT     Pyruvate
            L-Amino acid
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.12
            ExPASy - ENZYME nomenclature database: 2.6.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.12
            BRENDA, the Enzyme Database: 2.6.1.12
///
ENTRY       EC 2.6.1.13
NAME        Ornithine--oxo-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Ornithine:2-oxo-acid aminotransferase
REACTION    L-Ornithine + a 2-Oxo acid = L-Glutamate 5-semialdehyde +
            an L-Amino acid
SUBSTRATE   L-Ornithine
            2-Oxo acid
PRODUCT     L-Glutamate 5-semialdehyde
            L-Amino acid
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. PQQ ?
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b3073(ygjG)
            ECE: Z4426(ygjG)
            ECS: ECs3955
            MLO: mll1261
            BSU: BG10722(rocD)
            BHA: BH3943(rocD)
            SAU: SA0179 SA0818(rocD)
            SAV: SAV0180 SAV0944(rocD)
            MTU: Rv2321c(rocD2) Rv2322c(rocD1)
            DRA: DR1415
            SCE: YLR438W(CAR2)
            SPO: SPAC27F1.05C(spac27f1.05c) SPBC21C3.08C(spbc21c3.08c)
            ATH: At5g46180(MCL19.24)
            CEL: C16A3.9
            DME: CG8782
            MMU: 97394(Oat)
            HSA: 4942(OAT)
DISEASE     MIM: 258870  Ornithine aminotransferase
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
STRUCTURES  PDB: 2OAT  2CAN  1GBN  1OAT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.13
            ExPASy - ENZYME nomenclature database: 2.6.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.13
            BRENDA, the Enzyme Database: 2.6.1.13
            SCOP (Structural Classification of Proteins): 2.6.1.13
///
ENTRY       EC 2.6.1.14
NAME        Asparagine--oxo-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Asparagine:2-oxo-acid aminotransferase
REACTION    L-Asparagine + a 2-Oxo acid = 2-Oxosuccinamate + an Amino acid
SUBSTRATE   L-Asparagine
            2-Oxo acid
PRODUCT     2-Oxosuccinamate
            Amino acid
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00253  Tetracycline biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.14
            ExPASy - ENZYME nomenclature database: 2.6.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.14
            BRENDA, the Enzyme Database: 2.6.1.14
///
ENTRY       EC 2.6.1.15
NAME        Glutamine--pyruvate transaminase
            Glutaminase II
            Glutamine transaminase L
            Glutamine--oxo-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Glutamine:pyruvate aminotransferase
REACTION    L-Glutamine + Pyruvate = 2-Oxoglutaramate + L-Alanine
SUBSTRATE   L-Glutamine
            Pyruvate
            L-Methionine
            Glyoxylate
PRODUCT     2-Oxoglutaramate
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. L-Methionine can act as donor;
            glyoxylate can act as acceptor.
PATHWAY     PATH: MAP00251  Glutamate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.15
            ExPASy - ENZYME nomenclature database: 2.6.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.15
            BRENDA, the Enzyme Database: 2.6.1.15
///
ENTRY       EC 2.6.1.16
NAME        Glutamine--fructose-6-phosphate transaminase (isomerizing)
            Hexosephosphate aminotransferase
            Glucosamine-6-phosphate isomerase (glutamine-forming)
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Glutamine:D-fructose-6-phosphate aminotransferase
            (hexose isomerizing)
REACTION    L-Glutamine + D-Fructose 6-phosphate = L-Glutamate +
            D-Glucosamine 6-phosphate
SUBSTRATE   L-Glutamine
            D-Fructose 6-phosphate
PRODUCT     L-Glutamate
            D-Glucosamine 6-phosphate
COMMENT     Formerly EC 5.3.1.19.
            Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3729(glmS)
            ECE: Z5227(glmS)
            ECS: ECs4671
            YPE: YPO4118(glmS)
            HIN: HI0429(glmS)
            PMU: PM1731(glmS)
            XFA: XF0141
            VCH: VC0487
            PAE: PA5549(glmS)
            BUC: BU026(glmS)
            NME: NMB0031
            NMA: NMA0276(glmS)
            HPY: HP1532(glmS)
            HPJ: jhp1420
            CJE: Cj1366c(glmS)
            MLO: mll0833 mlr6386 mlr6774
            SME: SMc00231(glmS)
            CCR: CC0118
            BSU: BG10948(glmS) BG12712(ybcM)
            BHA: BH0268(glmS)
            SAU: SA1959(glmS)
            SAV: SAV2140(glmS)
            LLA: L33556(glmS)
            SPY: SPy1280(glmS)
            SPN: SP0266
            SPR: spr0245(glmS)
            CAC: CAC0158(glmS)
            MTU: Rv3436c(glmS)
            MTC: MT3542
            MLE: ML0371(glmS)
            CTR: CT816
            CMU: TC0203
            CPN: CPn0968
            CPA: CP0892
            CPJ: glmS
            TPA: TP0861
            SYN: sll0220(glmS)
            DRA: DR0302
            AAE: aq_301(glmS)
            TMA: TM0148
            MTH: MTH171 MTH860
            HAL: VNG0006G(glmS)
            PHO: PH0243
            PAB: PAB2201
            APE: APE1205
            SSO: SSO0382(glmS-1) SSO1268(glmS-2)
            SCE: YKL104C(GFA1)
            SPO: SPBC21D10.02
            ATH: At3g24090(F14O13.29)
            CEL: F07A11.2 F22B3.4
            DME: CG1345
            MMU: 95698(Gfpt)
            HSA: 2673(GFPT1) 9945(GFPT2)
DISEASE     MIM: 138292  Glutamine-fructose-6-phosphate transaminase
MOTIF       PS: PS00443  <x(0,11)-C-[GS]-[IV]-[LIVMFYW]-[AG]
STRUCTURES  PDB: 1MOS  1MOR  1MOQ  1GMS  1GDO  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.16
            ExPASy - ENZYME nomenclature database: 2.6.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.16
            BRENDA, the Enzyme Database: 2.6.1.16
            SCOP (Structural Classification of Proteins): 2.6.1.16
///
ENTRY       EC 2.6.1.17
NAME        Succinyldiaminopimelate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     N-Succinyl-L-2,6-diaminoheptanedioate:2-ocoglytarate amino-
            transferase
REACTION    N-Succinyl-LL-2,6-diaminoheptanedioate + 2-Oxoglutarate =
            N-Succinyl-2-L-amino-6-oxoheptanedioate + L-Glutamate
SUBSTRATE   N-Succinyl-LL-2,6-diaminoheptanedioate
            2-Oxoglutarate
PRODUCT     N-Succinyl-2-L-amino-6-oxoheptanedioate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b2379(yfdZ)
            ECE: Z3644
            ECS: ECs3259
            PAE: PA3659 PA4715
            NME: NMB0894
            NMA: NMA1113
            HPY: HP0624(aspB)
            HPJ: jhp0568
            CJE: Cj0150c
            MLO: mll0935
            CCR: CC1382
            BSU: BG12362(yugH) BG13281(ykrV)
            BHA: BH0936 BH1060 BH3350
            SAU: SA2347
            SAV: SAV2543
            CAC: CAC1715
            MTU: Rv0858c
            MTC: MT0881
            SYN: sll0006(aspC) sll0938
            DRA: DR2268
            AAE: aq_2094(aspC2) aq_273(aspC4)
            AFU: AF0409(aspB-4)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.17
            ExPASy - ENZYME nomenclature database: 2.6.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.17
            BRENDA, the Enzyme Database: 2.6.1.17
///
ENTRY       EC 2.6.1.18
NAME        beta-Alanine--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:3-oxopropanoate aminotransferase
REACTION    L-Alanine + 3-Oxopropanoate = Pyruvate + beta-Alanine
SUBSTRATE   L-Alanine
            3-Oxopropanoate
PRODUCT     Pyruvate
            beta-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       PAE: PA0132
            MLO: mll1632
            SME: SMc01534
            CCR: CC3143
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.18
            ExPASy - ENZYME nomenclature database: 2.6.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.18
            BRENDA, the Enzyme Database: 2.6.1.18
///
ENTRY       EC 2.6.1.19
NAME        4-Aminobutyrate transaminase
            beta-Alanine--oxoglutarate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     4-Aminobutanoate:2-oxoglutarate aminotransferase
REACTION    4-Aminobutanoate + 2-Oxoglutarate = Succinate semialdehyde +
            L-Glutamate
SUBSTRATE   4-Aminobutanoate
            2-Oxoglutarate
            beta-Alanine
            5-Aminopentanoate
            (R,S)-3-Amino-2-methylpropanoate
PRODUCT     Succinate semialdehyde
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     Some preparations also act on beta-alanine, 5-aminopentanoate
            and (R,S)-3-amino-2-methylpropanoate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1302(goaG) b2662(gabT)
            ECE: Z2486(goaG) Z3960(gabT)
            ECS: ECs1879 ECs3523
            YPE: YPO2844(goaG)
            VCH: VCA0605
            PAE: PA0266(gabT)
            MLO: mlr5521
            SME: SMb21186(gabT)
            BSU: BG12043(gabT)
            BHA: BH0991
            CAC: CAC0368 CAC1427(gabT)
            MTU: Rv2589(gabT) Rv3290c(lat)
            MTC: MT2666 MT3389
            MLE: ML0485(gabT)
            DRA: DRA0029
            HAL: VNG1524C
            TAC: Ta0068
            TVO: TVG0025258
            PHO: PH0138 PH0782 PH1423 PH1501
            PAB: PAB0086 PAB0501(gabT) PAB1921 PAB2386
            APE: APE0457
            SSO: SSO2727(gabT-1) SSO3211(gabT-2)
            STO: ST0735
            SCE: YGR019W(UGA1)
            SPO: SPAC19D5.07(spac19d5.07)
            CEL: K04D7.3
            DME: CG7433
            HSA: 18(ABAT)
DISEASE     MIM: 137150  4-aminobutyrate aminotransferase
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
STRUCTURES  PDB: 1GTX  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.19
            ExPASy - ENZYME nomenclature database: 2.6.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.19
            BRENDA, the Enzyme Database: 2.6.1.19
            SCOP (Structural Classification of Proteins): 2.6.1.19
///
ENTRY       EC 2.6.1.20
NAME        Deleted entry
            Tyrosine--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.20
            ExPASy - ENZYME nomenclature database: 2.6.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.20
///
ENTRY       EC 2.6.1.21
NAME        D-Alanine transaminase
            D-Aspartate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     D-Alanine:2-oxoglutarate aminotransferase
REACTION    D-Alanine + 2-Oxoglutarate = Pyruvate + D-Glutamate
SUBSTRATE   D-Alanine
            2-Oxoglutarate
            D-Leucine
            D-Aspartate
            D-Glutamate
            D-2-Aminobutyrate
            D-Norvaline
            D-Asparagine
PRODUCT     Pyruvate
            D-Glutamate
            4-Methyl-2-oxopentanoate
            Oxaloacetate
            2-Oxoglutarate
            Succinate semialdehyde
            2-Oxopentanoate
            gamma-Aminooxaloacetate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts on the D-isomers of leucine,
            aspartate, glutamate, aminobutyrate, norvaline and asparagine.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
            PATH: MAP00473  D-Alanine metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       MLO: mlr0401
            SME: SMa0093
            CCR: CC1744
            BSU: BG13045(dat)
            BHA: BH2811
            SAU: SA1571
            SAV: SAV1736
            CAC: CAC0792
MOTIF       PS: PS00770  E-x-[STAGCI]-x(2)-N-[LIVMFAC]-[FY]-x(6,12)-[LIVMFA]-x-
                         T-x(6,8)-[LIVM]-x-[GS]-[LIVM]-x-[KR]
STRUCTURES  PDB: 1A0G  1DAA  1G2W  2DAB  5DAA  2DAA  4DAA  3DAA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.21
            ExPASy - ENZYME nomenclature database: 2.6.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.21
            BRENDA, the Enzyme Database: 2.6.1.21
            SCOP (Structural Classification of Proteins): 2.6.1.21
///
ENTRY       EC 2.6.1.22
NAME        (S)-3-Amino-2-methylpropionate transaminase
            L-3-Aminoisobutyrate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     (S)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase
REACTION    (S)-3-Amino-2-methylpropanoate + 2-Oxoglutarate =
            2-Methyl-3-oxopropanoate + L-Glutamate
SUBSTRATE   (S)-3-Amino-2-methylpropanoate
            2-Oxoglutarate
PRODUCT     2-Methyl-3-oxopropanoate
            L-Glutamate
COMMENT     Also acts on beta-alanine and other omega-amino acids having
            carbon chains between 2 and 5. Not identical with EC 2.6.1.61.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.22
            ExPASy - ENZYME nomenclature database: 2.6.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.22
            BRENDA, the Enzyme Database: 2.6.1.22
///
ENTRY       EC 2.6.1.23
NAME        4-Hydroxyglutamate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     4-Hydroxy-L-glutamate:2-oxoglutarate aminotransferase
REACTION    4-Hydroxy-L-glutamate + 2-Oxoglutarate =
            4-Hydroxy-2-oxoglutarate + L-Glutamate
SUBSTRATE   4-Hydroxy-L-glutamate
            2-Oxoglutarate
            Oxaloacetate
PRODUCT     4-Hydroxy-2-oxoglutarate
            L-Glutamate
COMMENT     Oxaloacetate can replace 2-oxoglutarate. This enzyme may be
            identical with EC 2.6.1.1.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.23
            ExPASy - ENZYME nomenclature database: 2.6.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.23
            BRENDA, the Enzyme Database: 2.6.1.23
///
ENTRY       EC 2.6.1.24
NAME        Diiodotyrosine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     3,5-Diiodo-L-tyrosine:2-oxoglutarate aminotransferase
REACTION    3,5-Diiodo-L-tyrosine + 2-Oxoglutarate =
            3,5-Diiodo-4-hydroxyphenylpyruvate + L-Glutamate
SUBSTRATE   3,5-Diiodo-L-tyrosine
            2-Oxoglutarate
            3,5-Dichloro-L-tyrosine
            3,5-Dibromo-L-tyrosine
            3-Iodo-L-tyrosine
            Thyroxine
            Triiodothyronine
PRODUCT     3,5-Diiodo-4-hydroxyphenylpyruvate
            L-Glutamate
            3,5-Dichloro-4-hydroxyphenylpyruvate
            3,5-Dibromo-4-hydroxyphenylpyruvate
            3-Iodo-4-hydroxyphenylpyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on 3,5-dichloro-,
            3,5-dibromo- and 3-iodo-L-tyrosine, thyroxine and
            triiodothyronine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.24
            ExPASy - ENZYME nomenclature database: 2.6.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.24
            BRENDA, the Enzyme Database: 2.6.1.24
///
ENTRY       EC 2.6.1.25
NAME        Deleted entry
            Thyroxine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
COMMENT     Deleted entry. Now included with EC 2.6.1.24.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.25
            ExPASy - ENZYME nomenclature database: 2.6.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.25
///
ENTRY       EC 2.6.1.26
NAME        Thyroid-hormone transaminase
            3,5-Dinitrotyrosine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-3,5,3'-Triiodothyronine:2-oxoglutarate aminotransferase
REACTION    L-3,5,3'-Triiodothyronine + 2-Oxoglutarate =
            3,5,3'-Triiodophenylpyruvate + L-Glutamate
SUBSTRATE   L-3,5,3'-Triiodothyronine
            2-Oxoglutarate
            3,5-Diiodo-L-tyrosine
            Thyroxine
            3,5-Dinitro-L-tyrosine
            Pyruvate
            Oxaloacetate
PRODUCT     3,5,3'-Triiodophenylpyruvate
            L-Glutamate
            3,5-Diiodo-4-hydroxyphenylpyruvate
            3,5-Dinitro-4-hydroxyphenylpyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts on monoiodotyrosine,
            diiodotyrosine, triiodothyronine, thyroxine and dinitrotyrosine.
            (unlike EC 2.6.1.24, which does not act on dinitrotyrosine).
            Pyruvate or oxaloacetate can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.26
            ExPASy - ENZYME nomenclature database: 2.6.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.26
            BRENDA, the Enzyme Database: 2.6.1.26
///
ENTRY       EC 2.6.1.27
NAME        Tryptophan transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Tryptophan:2-oxoglutarate aminotransferase
REACTION    L-Tryptophan + 2-Oxoglutarate = Indolepyruvate + L-Glutamate
SUBSTRATE   L-Tryptophan
            2-Oxoglutarate
            5-Hydroxytryptophan
PRODUCT     Indolepyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan
            and, to a lesser extent, on the phenyl amino acids.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.27
            ExPASy - ENZYME nomenclature database: 2.6.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.27
            BRENDA, the Enzyme Database: 2.6.1.27
///
ENTRY       EC 2.6.1.28
NAME        Tryptophan--phenylpyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Tryptophan:phenylpyruvate aminotransferase
REACTION    L-Tryptophan + Phenylpyruvate = Indolepyruvate + L-Phenylalanine
SUBSTRATE   L-Tryptophan
            Phenylpyruvate
            L-Valine
            L-Leucine
            L-Isoleucine
PRODUCT     Indolepyruvate
            L-Phenylalanine
COMMENT     Valine, leucine and isoleucine can replace tryptophan as amino
            donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.28
            ExPASy - ENZYME nomenclature database: 2.6.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.28
            BRENDA, the Enzyme Database: 2.6.1.28
///
ENTRY       EC 2.6.1.29
NAME        Diamine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Diamine:2-oxoglutarate aminotransferase
REACTION    an alpha,omega-Diamine + 2-Oxoglutarate =
            an omega-Aminoaldehyde + L-Glutamate
SUBSTRATE   alpha,omega-Diamine
            2-Oxoglutarate
PRODUCT     omega-Aminoaldehyde
            L-Glutamate
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.29
            ExPASy - ENZYME nomenclature database: 2.6.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.29
            BRENDA, the Enzyme Database: 2.6.1.29
///
ENTRY       EC 2.6.1.30
NAME        Pyridoxamine--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Pyridoxamine:pyruvate aminotransferase
REACTION    Pyridoxamine + Pyruvate = Pyridoxal + L-Alanine
SUBSTRATE   Pyridoxamine
            Pyruvate
PRODUCT     Pyridoxal
            L-Alanine
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.30
            ExPASy - ENZYME nomenclature database: 2.6.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.30
            BRENDA, the Enzyme Database: 2.6.1.30
///
ENTRY       EC 2.6.1.31
NAME        Pyridoxamine--oxaloacetate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Pyridoxamine:oxaloacetate aminotransferase
REACTION    Pyridoxamine + Oxaloacetate = Pyridoxal + L-Aspartate
SUBSTRATE   Pyridoxamine
            Oxaloacetate
PRODUCT     Pyridoxal
            L-Aspartate
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.31
            ExPASy - ENZYME nomenclature database: 2.6.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.31
            BRENDA, the Enzyme Database: 2.6.1.31
///
ENTRY       EC 2.6.1.32
NAME        Valine--3-methyl-2-oxovalerate transaminase
            Valine--isoleucine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Valine:(S)-3-methyl-2-oxopentanoate aminotransferase
REACTION    L-Valine + (S)-3-Methyl-2-oxopentanoate =
            3-Methyl-2-oxobutanoate + L-Isoleucine
SUBSTRATE   L-Valine
            (S)-3-Methyl-2-oxopentanoate
PRODUCT     3-Methyl-2-oxobutanoate
            L-Isoleucine
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.32
            ExPASy - ENZYME nomenclature database: 2.6.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.32
            BRENDA, the Enzyme Database: 2.6.1.32
///
ENTRY       EC 2.6.1.33
NAME        dTDP-4-amino-4,6-dideoxy-D-glucose transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase
REACTION    dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate =
            dTDP-4-dehydro-6-deoxy-D-glucose + L-Glutamate
SUBSTRATE   dTDP-4-amino-4,6-dideoxy-D-glucose
            2-Oxoglutarate
PRODUCT     dTDP-4-dehydro-6-deoxy-D-glucose
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.33
            ExPASy - ENZYME nomenclature database: 2.6.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.33
            BRENDA, the Enzyme Database: 2.6.1.33
///
ENTRY       EC 2.6.1.34
NAME        UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate
            $ aminotransferase
REACTION    UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose + 2-Oxoglutarate =
            UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose + L-Glutamate
SUBSTRATE   UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose
            2-Oxoglutarate
PRODUCT     UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.34
            ExPASy - ENZYME nomenclature database: 2.6.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.34
            BRENDA, the Enzyme Database: 2.6.1.34
///
ENTRY       EC 2.6.1.35
NAME        Glycine--oxaloacetate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Glycine:oxaloacetate aminotransferase
REACTION    Glycine + Oxaloacetate = Glyoxylate + L-Aspartate
SUBSTRATE   Glycine
            Oxaloacetate
PRODUCT     Glyoxylate
            L-Aspartate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.35
            ExPASy - ENZYME nomenclature database: 2.6.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.35
            BRENDA, the Enzyme Database: 2.6.1.35
///
ENTRY       EC 2.6.1.36
NAME        L-Lysine 6-transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Lysine:2-oxoglutarate 6-aminotransferase
REACTION    L-Lysine + 2-Oxoglutarate = L-2-Aminoadipate 6-semialdehyde +
            L-Glutamate
SUBSTRATE   L-Lysine
            2-Oxoglutarate
PRODUCT     L-2-Aminoadipate 6-semialdehyde
            L-Glutamate
            1-Piperideine 6-carboxylate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The product (allysine) is converted
            into the intramolecularly dehydrated form, 1-piperideine
            6-carboxylate.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.36
            ExPASy - ENZYME nomenclature database: 2.6.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.36
            BRENDA, the Enzyme Database: 2.6.1.36
///
ENTRY       EC 2.6.1.37
NAME        (2-Aminoethyl)phosphonate--pyruvate transaminase
            (2-Aminoethyl)phosphonate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     (2-Aminoethyl)phosphonate:pyruvate aminotransferase
REACTION    (2-Aminoethyl)phosphonate + Pyruvate = 2-Phosphonoacetaldehyde +
            L-Alanine
SUBSTRATE   (2-Aminoethyl)phosphonate
            Pyruvate
PRODUCT     2-Phosphonoacetaldehyde
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.37
            ExPASy - ENZYME nomenclature database: 2.6.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.37
            BRENDA, the Enzyme Database: 2.6.1.37
///
ENTRY       EC 2.6.1.38
NAME        Histidine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Histidine:2-oxoglutarate aminotransferase
REACTION    L-Histidine + 2-Oxoglutarate = Imidazol-5-yl-pyruvate +
            L-Glutamate
SUBSTRATE   L-Histidine
            2-Oxoglutarate
PRODUCT     Imidazol-5-yl-pyruvate
            L-Glutamate
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.38
            ExPASy - ENZYME nomenclature database: 2.6.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.38
            BRENDA, the Enzyme Database: 2.6.1.38
///
ENTRY       EC 2.6.1.39
NAME        2-Aminoadipate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-2-Aminoadipate:2-oxoglutarate aminotransferase
REACTION    L-2-Aminoadipate + 2-Oxoglutarate = 2-Oxoadipate + L-Glutamate
SUBSTRATE   L-2-Aminoadipate
            2-Oxoglutarate
PRODUCT     2-Oxoadipate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.39
            ExPASy - ENZYME nomenclature database: 2.6.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.39
            BRENDA, the Enzyme Database: 2.6.1.39
///
ENTRY       EC 2.6.1.40
NAME        (R)-3-Amino-2-methylpropionate--pyruvate transaminase
            D-3-Aminoisobutyrate--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
REACTION    (R)-3-Amino-2-methylpropanoate + Pyruvate =
            2-Methyl-3-oxopropanoate + L-Alanine
SUBSTRATE   (R)-3-Amino-2-methylpropanoate
            Pyruvate
PRODUCT     2-Methyl-3-oxopropanoate
            L-Alanine
GENES       RPR: RP294(gppA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.40
            ExPASy - ENZYME nomenclature database: 2.6.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.40
            BRENDA, the Enzyme Database: 2.6.1.40
///
ENTRY       EC 2.6.1.41
NAME        D-Methionine--pyruvate transaminase
            D-Methionine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     D-Methionine:pyruvate aminotransferase
REACTION    D-Methionine + Pyruvate = 4-Methylthio-2-oxobutanoate + L-Alanine
SUBSTRATE   D-Methionine
            Pyruvate
            Oxaloacetate
PRODUCT     4-Methylthio-2-oxobutanoate
            L-Alanine
            L-Aspartate
COMMENT     Oxaloacetate can replace pyruvate.
PATHWAY     PATH: MAP00473  D-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.41
            ExPASy - ENZYME nomenclature database: 2.6.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.41
            BRENDA, the Enzyme Database: 2.6.1.41
///
ENTRY       EC 2.6.1.42
NAME        Branched-chain-amino-acid transaminase
            Transaminase B
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Branched-chain-amino-acid:2-oxoglutarate aminotransferase
REACTION    L-Leucine + 2-Oxoglutarate = 4-Methyl-2-oxopentanoate +
            L-Glutamate
SUBSTRATE   L-Leucine
            L-Isoleucine
            L-Valine
            2-Oxoglutarate
PRODUCT     4-Methyl-2-oxopentanoate
            L-Glutamate
            3-Methyl-2-oxopentanoate
            3-Methyl-2-oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     Also acts on L-isoleucine and L-valine. Different from
            EC 2.6.1.66.
            (EC 2.6.1.66 Valine-pyruvate aminotransferase)
            A pyridoxal-phosphate protein (J.Biochem.,104,777-784 (1988)).
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b3770(ilvE)
            ECE: Z5281(ilvE)
            ECS: ECs4704
            YPE: YPO3899(ilvE)
            HIN: HI1193(ilvE)
            PMU: PM0566(ivlE)
            XFA: XF1999
            VCH: VC0029
            PAE: PA5013(ilvE)
            NME: NMB0337
            NMA: NMA2151(ilvE)
            HPY: HP1468(ilvE)
            HPJ: jhp1361
            CJE: Cj0269c(ilvE)
            RPR: RP428(ilvE)
            RCO: RC0594(ilvE)
            MLO: mll2664 mll9205 mlr1594 mlr7635
            SME: SMc00042(ilvE2) SMc02896(ilvE1)
            CCR: CC2929
            BSU: BG10546(ywaA) BG12749(ybgE)
            BHA: BH2156(bcaT)
            SAU: SA0512(ilvE)
            SAV: SAV0543
            LLA: L0086(bcaT)
            SPY: SPy0911(bcaT)
            SPN: SP0856
            SPR: spr0758(ilvE)
            CAC: CAC1479(ilvE)
            MTU: Rv2210c(ilvE)
            MTC: MT2266
            MLE: ML0866(ilvE)
            SYN: slr0032(ilvE)
            DRA: DR1626
            AAE: aq_1893(ilvE)
            TMA: TM0831
            MJA: MJ1008(ilvE)
            MTH: MTH1430
            AFU: AF0933(ilvE)
            HAL: VNG0387G(ilvE1) VNG2122G(ilvE2)
            SCE: YHR208W(BAT1) YJR148W(BAT2)
            SPO: ECA39(eca39)
            ATH: At1g10060(T27I1.8) At1g10070(T27I1.9) At1g50090(F2J10.5)
                 At1g50110(F2J10.4) At3g05190(T12H1.16) At3g19710(MMB12.20)
                 At3g49680(T16K5.30) At5g65780(MPA24.13)
            CEL: K02A4.1 Y44A6D.5
            DME: CG1673
            HSA: 586(BCAT1) 587(BCAT2)
MOTIF       PS: PS00770  E-x-[STAGCI]-x(2)-N-[LIVMFAC]-[FY]-x(6,12)-[LIVMFA]-x-
                         T-x(6,8)-[LIVM]-x-[GS]-[LIVM]-x-[KR]
STRUCTURES  PDB: 1I1L  1I1M  1A3G  1EKF  1EKP  1EKV  1I1K  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.42
            ExPASy - ENZYME nomenclature database: 2.6.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.42
            BRENDA, the Enzyme Database: 2.6.1.42
            SCOP (Structural Classification of Proteins): 2.6.1.42
///
ENTRY       EC 2.6.1.43
NAME        Aminolevulinate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     5-Aminolevulinate:pyruvate aminotransferase
REACTION    5-Aminolevulinate + Pyruvate = 4,5-Dioxopentanoate + L-Alanine
SUBSTRATE   5-Aminolevulinate
            Pyruvate
PRODUCT     4,5-Dioxopentanoate
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.43
            ExPASy - ENZYME nomenclature database: 2.6.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.43
            BRENDA, the Enzyme Database: 2.6.1.43
///
ENTRY       EC 2.6.1.44
NAME        Alanine--glyoxylate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:glyoxylate aminotransferase
REACTION    L-Alanine + Glyoxylate = Pyruvate + Glycine
SUBSTRATE   L-Alanine
            Glyoxylate
            2-Oxobutanoate
            3-Hydroxypyruvate
PRODUCT     Pyruvate
            Glycine
            L-Serine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. With one component of the
            animal enzyme, 2-oxobutanoate can replace glyoxylate.
            A second component also catalyses the reaction of EC 2.6.1.51.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       CEL: T14D7.1
            DME: CG3926(Spat)
            HSA: 189(AGXT)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00595  [LIVFYCHT]-[DGH]-[LIVMFYAC]-[LIVMFYA]-x(2)-[GSTAC]-
                         [GSTA]-[HQR]-K-x(4,6)-G-x-[GSAT]-x-[LIVMFYSAC]
            PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.44
            ExPASy - ENZYME nomenclature database: 2.6.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.44
            BRENDA, the Enzyme Database: 2.6.1.44
///
ENTRY       EC 2.6.1.45
NAME        Serine--glyoxylate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Serine:glyoxylate aminotransferase
REACTION    L-Serine + Glyoxylate = 3-Hydroxypyruvate + Glycine
SUBSTRATE   L-Serine
            Glyoxylate
PRODUCT     3-Hydroxypyruvate
            Glycine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       SME: SMa2139(sgaA)
MOTIF       PS: PS00595  [LIVFYCHT]-[DGH]-[LIVMFYAC]-[LIVMFYA]-x(2)-[GSTAC]-
                         [GSTA]-[HQR]-K-x(4,6)-G-x-[GSAT]-x-[LIVMFYSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.45
            ExPASy - ENZYME nomenclature database: 2.6.1.45
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.45
            BRENDA, the Enzyme Database: 2.6.1.45
///
ENTRY       EC 2.6.1.46
NAME        Diaminobutyrate--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-2,4-Diaminobutanoate:pyruvate aminotransferase
REACTION    L-2,4-Diaminobutanoate + Pyruvate = L-Aspartate 4-semialdehyde +
            L-Alanine
SUBSTRATE   L-2,4-Diaminobutanoate
            Pyruvate
PRODUCT     L-Aspartate 4-semialdehyde
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
GENES       HIN: HI0949
            VCH: VCA0824
            PAE: PA2413
            MLO: mlr5943
            BHA: BH0919 BH2624
            HAL: VNG6210G(gabT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.46
            ExPASy - ENZYME nomenclature database: 2.6.1.46
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.46
            BRENDA, the Enzyme Database: 2.6.1.46
///
ENTRY       EC 2.6.1.47
NAME        Alanine--oxomalonate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:oxomalonate aminotransferase
REACTION    L-Alanine + Oxomalonate = Pyruvate + Aminomalonate
SUBSTRATE   L-Alanine
            Oxomalonate
PRODUCT     Pyruvate
            Aminomalonate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.47
            ExPASy - ENZYME nomenclature database: 2.6.1.47
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.47
            BRENDA, the Enzyme Database: 2.6.1.47
///
ENTRY       EC 2.6.1.48
NAME        5-Aminovalerate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     5-Aminopentanoate:2-oxoglutarate aminotransferase
REACTION    5-Aminopentanoate + 2-Oxoglutarate = 5-Oxopentanoate + L-Glutamate
SUBSTRATE   5-Aminopentanoate
            2-Oxoglutarate
PRODUCT     5-Oxopentanoate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.48
            ExPASy - ENZYME nomenclature database: 2.6.1.48
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.48
            BRENDA, the Enzyme Database: 2.6.1.48
///
ENTRY       EC 2.6.1.49
NAME        Dihydroxyphenylalanine transaminase
            Dopa transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     3,4-Dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase
REACTION    3,4-Dihydroxy-L-phenylalanine + 2-Oxoglutarate =
            3-(3,4-Dihydroxyphenyl)pyruvate + L-Glutamate
SUBSTRATE   3,4-Dihydroxy-L-phenylalanine
            2-Oxoglutarate
PRODUCT     3-(3,4-Dihydroxyphenyl)pyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.49
            ExPASy - ENZYME nomenclature database: 2.6.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.49
            BRENDA, the Enzyme Database: 2.6.1.49
///
ENTRY       EC 2.6.1.50
NAME        Glutamine--scyllo-inosose transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase
REACTION    L-Glutamine + 2,4,6/3,5-Pentahydroxycyclohexanone =
            2-Oxoglutamate + 1-Amino-1-deoxy-scyllo-inositol
SUBSTRATE   L-Glutamine
            2,4,6/3,5-Pentahydroxycyclohexanone
PRODUCT     2-Oxoglutamate
            1-Amino-1-deoxy-scyllo-inositol
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.50
            ExPASy - ENZYME nomenclature database: 2.6.1.50
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.50
            BRENDA, the Enzyme Database: 2.6.1.50
///
ENTRY       EC 2.6.1.51
NAME        Serine--pyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Serine:pyruvate aminotransferase
REACTION    L-Serine + Pyruvate = 3-Hydroxypyruvate + L-Alanine
SUBSTRATE   L-Serine
            Pyruvate
PRODUCT     3-Hydroxypyruvate
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The liver enzyme may be
            identical with EC 2.6.1.44.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       SME: SMa1495
            SSO: SSO2597(agxT)
            STO: ST0602
            CEL: T14D7.1
            DME: CG3926(Spat)
            HSA: 189(AGXT)
DISEASE     MIM: 604285  Alanine-glyoxylate aminotransferase, liver-specific
                         peroxisomal
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00595  [LIVFYCHT]-[DGH]-[LIVMFYAC]-[LIVMFYA]-x(2)-[GSTAC]-
                         [GSTA]-[HQR]-K-x(4,6)-G-x-[GSAT]-x-[LIVMFYSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.51
            ExPASy - ENZYME nomenclature database: 2.6.1.51
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.51
            BRENDA, the Enzyme Database: 2.6.1.51
///
ENTRY       EC 2.6.1.52
NAME        Phosphoserine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     O-Phospho-L-serine:2-oxoglutarate aminotransferase
REACTION    O-Phospho-L-serine + 2-Oxoglutarate = 3-Phosphonooxypyruvate +
            L-Glutamate
SUBSTRATE   O-Phospho-L-serine
            2-Oxoglutarate
PRODUCT     3-Phosphonooxypyruvate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00750  Vitamin B6 metabolism
GENES       ECO: b0907(serC)
            ECE: Z1253(serC)
            ECS: ECs0990
            YPE: YPO1389(serC)
            HIN: HI1167(serC)
            PMU: PM0837(serC)
            XFA: XF2326
            VCH: VC1159
            PAE: PA3167(serC)
            BUC: BU312(serC)
            NME: NMB1640
            NMA: NMA1894(serC)
            CJE: Cj0326(serC)
            MLO: mll3876
            SME: SMc00640(serC)
            CCR: CC3216
            BSU: BG12673(serC)
            BHA: BH1188(serC)
            LLA: L0083(serC)
            MTU: Rv0884c(serC)
            MTC: MT0907
            MLE: ML2136(serC)
            SCE: YOR184W(SER1)
            SPO: SPAC1F12.07(spac1f12.07)
            ATH: At2g17630(T19E12.3) At4g35630(F8D20.140)
            CEL: F26H9.5
            DME: CG11899
            HSA: 29968(PSA)
MOTIF       PS: PS00595  [LIVFYCHT]-[DGH]-[LIVMFYAC]-[LIVMFYA]-x(2)-[GSTAC]-
                         [GSTA]-[HQR]-K-x(4,6)-G-x-[GSAT]-x-[LIVMFYSAC]
STRUCTURES  PDB: 1BJO  1BT4  1BJN  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.52
            ExPASy - ENZYME nomenclature database: 2.6.1.52
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.52
            BRENDA, the Enzyme Database: 2.6.1.52
            SCOP (Structural Classification of Proteins): 2.6.1.52
///
ENTRY       EC 2.6.1.53
NAME        Transferred to EC 1.4.1.13
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
COMMENT     Transferred entry. Now EC 1.4.1.13 - Glutamate synthase (NADPH).
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.53
            ExPASy - ENZYME nomenclature database: 2.6.1.53
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.53
///
ENTRY       EC 2.6.1.54
NAME        Pyridoxamine-phosphate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase
REACTION    Pyridoxamine 5'-phosphate + 2-Oxoglutarate =
            Pyridoxal 5'-phosphate + D-Glutamate
SUBSTRATE   Pyridoxamine 5'-phosphate
            2-Oxoglutarate
PRODUCT     Pyridoxal 5'-phosphate
            D-Glutamate
COMMENT     Also acts, more slowly, on pyridoxamine.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.54
            ExPASy - ENZYME nomenclature database: 2.6.1.54
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.54
            BRENDA, the Enzyme Database: 2.6.1.54
///
ENTRY       EC 2.6.1.55
NAME        Taurine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Taurine:2-oxoglutarate aminotransferase
REACTION    Taurine + 2-Oxoglutarate = Sulfoacetaldehyde + L-Glutamate
SUBSTRATE   Taurine
            2-Oxoglutarate
            D-3-Amino-isobutanoate
            L-3-Amino-isobutanoate
            beta-Alanine
            3-Aminopropanesulfonate
PRODUCT     Sulfoacetaldehyde
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on D L-3-amino-
            isobutanoate, beta-alanine and 3-aminopropanesulfonate.
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.55
            ExPASy - ENZYME nomenclature database: 2.6.1.55
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.55
            BRENDA, the Enzyme Database: 2.6.1.55
///
ENTRY       EC 2.6.1.56
NAME        1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate
            $ aminotransferase
REACTION    1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol + Pyruvate =
            1D-1-Guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-Alanine
SUBSTRATE   1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol
            Pyruvate
            L-Glutamate
            L-Glutamine
PRODUCT     1D-1-Guanidino-1-deoxy-3-dehydro-scyllo-inositol
            L-Alanine
            2-Oxoglutarate
            2-Oxoglutamate
COMMENT     L-Glutamate and L-glutamine can also act as amino donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.56
            ExPASy - ENZYME nomenclature database: 2.6.1.56
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.56
            BRENDA, the Enzyme Database: 2.6.1.56
///
ENTRY       EC 2.6.1.57
NAME        Aromatic-amino-acid transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Aromatic-amino-acid:2-oxoglutarate aminotransferase
REACTION    an Aromatic amino acid + 2-Oxoglutarate = an Aromatic oxo acid +
            L-Glutamate
SUBSTRATE   Aromatic amino acid
            2-Oxoglutarate
            Oxaloacetate
PRODUCT     Aromatic oxo acid
            L-Glutamate
            L-Aspartate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. L-Methionine can also act as donor,
            more slowly; oxaloacetate can act as acceptor. Controlled
            proteolysis converts the enzyme into EC 2.6.1.1.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       ECO: b4054(tyrB)
            ECE: Z5652(tyrB)
            ECS: ECs5036
            YPE: YPO0322(tyrB)
            XFA: XF0036
            PAE: PA3139
            NME: NMB1678
            NMA: NMA1937(tyrB)
            MLO: mll0405
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
STRUCTURES  PDB: 2AY4  2AY3  2AY6  2AY7  2AY2  2AY9  3TAT  2AY1  1AY8  1AY5  
                 1AY4  2AY5  2AY8  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.57
            ExPASy - ENZYME nomenclature database: 2.6.1.57
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.57
            BRENDA, the Enzyme Database: 2.6.1.57
            SCOP (Structural Classification of Proteins): 2.6.1.57
///
ENTRY       EC 2.6.1.58
NAME        Phenylalanine(histidine) transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Phenylalanine(L-histidine):pyruvate aminotransferase
REACTION    L-Phenylalanine + Pyruvate = Phenylpyruvate + L-Alanine
SUBSTRATE   L-Phenylalanine
            Pyruvate
            L-Histidine
            L-Tyrosine
            2-Oxoglutamate
PRODUCT     Phenylpyruvate
            L-Alanine
            3-(4-Hydroxyphenyl)pyruvate
            L-Methionine
            L-Serine
            L-Glutamine
COMMENT     L-Histidine and L-tyrosine can act instead of L-phenylalanine; in
            the reverse reaction, L-methionine, L-serine and L-glutamine can
            replace L-alanine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.58
            ExPASy - ENZYME nomenclature database: 2.6.1.58
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.58
            BRENDA, the Enzyme Database: 2.6.1.58
///
ENTRY       EC 2.6.1.59
NAME        dTDP-4-amino-4,6-dideoxygalactose transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase
REACTION    dTDP-4-amino-4,6-dideoxy-D-galactose + 2-Oxoglutarate =
            dTDP-4-dehydro-6-deoxy-D-galactose + L-Glutamate
SUBSTRATE   dTDP-4-amino-4,6-dideoxy-D-galactose
            2-Oxoglutarate
PRODUCT     dTDP-4-dehydro-6-deoxy-D-galactose
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.59
            ExPASy - ENZYME nomenclature database: 2.6.1.59
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.59
            BRENDA, the Enzyme Database: 2.6.1.59
///
ENTRY       EC 2.6.1.60
NAME        Aromatic-amino-acid--glyoxylate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     Aromatic-amino-acid:glyoxylate aminotransferase
REACTION    an Aromatic amino acid + Glyoxylate = an Aromatic oxo acid +
            Glycine
SUBSTRATE   Aromatic amino acid
            Glyoxylate
            Phenylalanine
            Kynurenine
            Tyrosine
            Histidine
            Pyruvate
            Hydroxypyruvate
PRODUCT     Aromatic oxo acid
            Glycine
COMMENT     Phenylalanine, kynurenine, tyrosine and histidine can act as
            amino donors; glyoxylate, pyruvate and hydroxypyruvate can act as
            amino acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.60
            ExPASy - ENZYME nomenclature database: 2.6.1.60
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.60
            BRENDA, the Enzyme Database: 2.6.1.60
///
ENTRY       EC 2.6.1.61
NAME        (R)-3-Amino-2-methylpropanoate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase
REACTION    (R)-3-Amino-2-methylpropanoate + 2-Oxoglutarate =
            2-Methyl-3-oxopropanoate + L-Glutamate
SUBSTRATE   (R)-3-Amino-2-methylpropanoate
            2-Oxoglutarate
PRODUCT     2-Methyl-3-oxopropanoate
            L-Glutamate
COMMENT     Not identical with EC 2.6.1.22.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.61
            ExPASy - ENZYME nomenclature database: 2.6.1.61
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.61
            BRENDA, the Enzyme Database: 2.6.1.61
///
ENTRY       EC 2.6.1.62
NAME        Adenosylmethionine--8-amino-7-oxononanoate transaminase
            7,8-Diaminononanoate transaminase
            DAPA transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     S-Adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase
REACTION    S-Adenosyl-L-methionine + 8-Amino-7-oxononanoate =
            S-Adenosyl-4-methylthio-2-oxobutanoate + 7,8-Diaminononanoate
SUBSTRATE   S-Adenosyl-L-methionine
            8-Amino-7-oxononanoate
            S-Adenosyl-L-homocysteine
PRODUCT     S-Adenosyl-4-methylthio-2-oxobutanoate
            7,8-Diaminononanoate
COFACTOR    Pyridoxal phosphate
COMMENT     S-Adenosylhomocysteine can also act as donor.
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       ECO: b0774(bioA)
            ECE: Z0993(bioA)
            ECS: ECs0852
            YPE: YPO1150(bioA)
            HIN: HI1554(bioA)
            PMU: PM1900(bioA)
            XFA: XF0189
            VCH: VC1111
            PAE: PA0420(bioA)
            BUC: BU292(bioA)
            NME: NMB0732
            NMA: NMA0942(bioA)
            HPY: HP0976(bioA)
            HPJ: jhp0910
            CJE: Cj0307(bioA)
            MLO: mll5828 mll6003 mll9097
            CCR: CC1577
            BSU: BG11524(bioA)
            BHA: BH0782
            SAU: SA2214(bioA)
            SAV: SAV2410(bioA)
            CAC: CAC1362(bioA)
            MTU: Rv1568(bioA)
            MTC: MT1619
            MLE: ML1216(bioA)
            CPN: CPn1041
            CPA: CP0811
            CPJ: bioA
            AAE: aq_170(bioA)
            MJA: MJ1300(bioA)
            SCE: YNR058W(BIO3)
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
STRUCTURES  PDB: 1QJ5  1QJ3  1DTY  
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.62
            ExPASy - ENZYME nomenclature database: 2.6.1.62
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.62
            BRENDA, the Enzyme Database: 2.6.1.62
            SCOP (Structural Classification of Proteins): 2.6.1.62
///
ENTRY       EC 2.6.1.63
NAME        Kynurenine--glyoxylate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Kynurenine:glyoxylote aminotransferase (cyclizing)
REACTION    L-Kynurenine + Glyoxylate =
            4-(2-Aminophenyl)-2,4-dioxobutanoate + Glycine
SUBSTRATE   L-Kynurenine
            Glyoxylate
PRODUCT     4-(2-Aminophenyl)-2,4-dioxobutanoate
            Glycine
COMMENT     Acts, more slowly, on L-phenylalanine, L-histidine and L-tyrosine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.63
            ExPASy - ENZYME nomenclature database: 2.6.1.63
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.63
            BRENDA, the Enzyme Database: 2.6.1.63
///
ENTRY       EC 2.6.1.64
NAME        Glutamine--phenylpyruvate transaminase
            Glutamine transaminase K
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Glutamine:phenylpyruvate aminotransferase
REACTION    L-Glutamine + Phenylpyruvate = 2-Oxoglutaramate + L-Phenylalanine
SUBSTRATE   L-Glutamine
            Phenylpyruvate
PRODUCT     2-Oxoglutaramate
            L-Phenylalanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. L-Methionine, L-histidine and
            L-tyrosine can act as donors. The enzyme has little activity on
            pyruvate and glyoxylate (cf. EC 2.6.1.15).
GENES       HSA: 883(CCBL1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.64
            ExPASy - ENZYME nomenclature database: 2.6.1.64
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.64
            BRENDA, the Enzyme Database: 2.6.1.64
///
ENTRY       EC 2.6.1.65
NAME        N6-Acetyl-beta-lysine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     6-Acetamido-3-aminohexanoate:2-oxoglutarata aminotransferase
REACTION    6-Acetamido-3-aminohexanoate + 2-Oxoglutarate =
            6-Acetamido-3-oxohexanoate + L-Glutamate
SUBSTRATE   6-Acetamido-3-aminohexanoate
            2-Oxoglutarate
PRODUCT     6-Acetamido-3-oxohexanoate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyricoxal-phosphate protein.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.65
            ExPASy - ENZYME nomenclature database: 2.6.1.65
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.65
            BRENDA, the Enzyme Database: 2.6.1.65
///
ENTRY       EC 2.6.1.66
NAME        Valine--pyruvate transaminase
            Transaminase C
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Valine:pyruvate aminotransferase
REACTION    L-Valine + Pyruvate = 3-Methyl-2-oxobutanoate + L-Alanine
SUBSTRATE   L-Valine
            Pyruvate
PRODUCT     3-Methyl-2-oxobutanoate
            L-Alanine
COMMENT     Different from EC 2.6.1.42
            (EC 2.6.1.42 Branched -chain-amino-acid aminotransferase
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
GENES       ECO: b3572(avtA)
            ECE: Z4997(avtA)
            ECS: ECs4455
            YPE: YPO4082(avtA)
            VCH: VC0019
            NME: NMB1823
            NMA: NMA0636(avtA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.66
            ExPASy - ENZYME nomenclature database: 2.6.1.66
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.66
            BRENDA, the Enzyme Database: 2.6.1.66
///
ENTRY       EC 2.6.1.67
NAME        2-Aminohexanoate transaminase
            Norleucin transaminate
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-2-Aminohexanoate:2-oxoglutarate aminotransferase
REACTION    L-2-Aminohexanoate + 2-Oxoglutarate = 2-Oxohexanoate + L-Glutamate
SUBSTRATE   L-2-Aminohexanoate
            2-Oxoglutarate
            L-Leucine
PRODUCT     2-Oxohexanoate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on L-leucine and, more
            slowly, on L-isoleucine, L-2--aminopentanoate and L-aspartate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.67
            ExPASy - ENZYME nomenclature database: 2.6.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.67
            BRENDA, the Enzyme Database: 2.6.1.67
///
ENTRY       EC 2.6.1.68
NAME        Ornithine(lysine) transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Ornithine(L-lysine):2-oxoglutarate omega-aminotransferase
REACTION    L-Ornithine + 2-Oxoglutarate =
            3,4-Dihydro-2H-Pyrrole-2-carboxylate + L-Glutamate
SUBSTRATE   L-Ornithine
            2-Oxoglutarate
            L-Lysine
PRODUCT     3,4-Dihydro-2H-Pyrrole-2-carboxylate
            L-Glutamate
            2,3,4,5-Tetrahydropyridine-2-carboxylate
COMMENT     Also acts on L-lysine, producing 2,3,4,5-tetrahydropyridine-
            -2-carboxylate. From Trichomonas vaginalis.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.68
            ExPASy - ENZYME nomenclature database: 2.6.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.68
            BRENDA, the Enzyme Database: 2.6.1.68
///
ENTRY       EC 2.6.1.69
NAME        N2-Acetylornithine 5-transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     N2-Acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
REACTION    N2-Acetyl-L-ornithine + 2-Oxoglutarate =
            2-Acetamido-5-oxopentanoate + L-Glutamate
SUBSTRATE   N2-Acetyl-L-ornithine
            2-Oxoglutarate
            L-Ornithine
            N2-Succinyl-L-ornithine
PRODUCT     2-Acetamido-5-oxopentanoate
            L-Glutamate
COMMENT     Also acts on L-ornithine and N2-Succinyl-L-ornithine.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.69
            ExPASy - ENZYME nomenclature database: 2.6.1.69
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.69
            BRENDA, the Enzyme Database: 2.6.1.69
///
ENTRY       EC 2.6.1.70
NAME        Aspartate--phenylpyruvate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Aspartate:phenylpyruvate aminotransferase
REACTION    L-Aspartate + Phenylpyruvate = Oxaloacetate + L-Phenylalanine
SUBSTRATE   L-Aspartate
            Phenylpyruvate
PRODUCT     Oxaloacetate
            L-Phenylalanine
COMMENT     The enzyme from Pseudomonas putida also acts on 4-hydroxy
            -phenylpyruvate and, more slowly, on L-glutamate and L-histidine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.70
            ExPASy - ENZYME nomenclature database: 2.6.1.70
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.70
            BRENDA, the Enzyme Database: 2.6.1.70
///
ENTRY       EC 2.6.1.71
NAME        Lysine--pyruvate 6-transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Lysine:pyruvate aminotransferase
REACTION    L-Lysine + Pyruvate = L-2-Aminoadipate 6-semialdehyde + L-Alanine
SUBSTRATE   L-Lysine
            Pyruvate
PRODUCT     L-2-Aminoadipate 6-semialdehyde
            L-Alanine
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.71
            ExPASy - ENZYME nomenclature database: 2.6.1.71
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.71
            BRENDA, the Enzyme Database: 2.6.1.71
///
ENTRY       EC 2.6.1.72
NAME        D-4-Hydroxyphenylglycine transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     D-4-Hydroxyphenylglycine:2-oxoglutarate aminotransferase
REACTION    D-4-Hydroxyphenylglycine + 2-Oxoglutarate =
            4-Hydroxyphenylglyoxylate + L-Glutamate
SUBSTRATE   D-4-Hydroxyphenylglycine
            2-Oxoglutarate
PRODUCT     4-Hydroxyphenylglyoxylate
            L-Glutamate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.72
            ExPASy - ENZYME nomenclature database: 2.6.1.72
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.72
            BRENDA, the Enzyme Database: 2.6.1.72
///
ENTRY       EC 2.6.1.73
NAME        Methionine--glyoxylate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Methionine:glyoxylate aminotransferase
REACTION    L-Methionine + Glyoxylate = 4-Methylthio-2-oxobutanoate + Glycine
SUBSTRATE   L-Methionine
            Glyoxylate
            L-Glutamate
PRODUCT     4-Methylthio-2-oxobutanoate
            Glycine
            2-Oxoglutarate
COMMENT     L-Glutamate can also act as donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.73
            ExPASy - ENZYME nomenclature database: 2.6.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.73
            BRENDA, the Enzyme Database: 2.6.1.73
///
ENTRY       EC 2.6.1.74
NAME        Cephalosporin-C transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-Alanine:cephalosporin-C aminotransferase
REACTION    Cephalosporin C + Pyruvate =
            7-(5-Carboxyl-5-oxopentanyl)-aminocephalosporinate + L-Alanine
SUBSTRATE   Cephalosporin C
            Pyruvate
PRODUCT     7-(5-Carboxyl-5-oxopentanyl)-aminocephalosporinate
            L-Alanine
COMMENT     A number of D-amino acids can also act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.74
            ExPASy - ENZYME nomenclature database: 2.6.1.74
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.74
            BRENDA, the Enzyme Database: 2.6.1.74
///
ENTRY       EC 2.6.1.75
NAME        Cysteine-conjugate transaminase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     S-(4-Bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase
REACTION    S-(4-Bromophenyl)-L-cysteine + 2-Oxoglutarate =
            S-(4-Bromophenyl)-mercaptopyruvate + L-Glutamate
SUBSTRATE   S-(4-Bromophenyl)-L-cysteine
            2-Oxoglutarate
PRODUCT     S-(4-Bromophenyl)-mercaptopyruvate
            L-Glutamate
COMMENT     A number of cysteine conjugates can also act.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.75
            ExPASy - ENZYME nomenclature database: 2.6.1.75
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.75
            BRENDA, the Enzyme Database: 2.6.1.75
///
ENTRY       EC 2.6.1.76
NAME        Diaminobutyrate-2-oxoglutarate transaminase
            L-2,4-Diaminobutyrate:2-ketoglutarate 4-aminotransferase
            2,4-Diaminobutyrate 4-aminotransferase
CLASS       Transferases
            Transferring nitrogenous groups
            Transaminases
SYSNAME     L-2,4-Diaminobutyrate:2-oxoglutarate 4-aminotransferase
REACTION    L-2,4-Diaminobutyrate + 2-Oxoglutarate = L-Glutamate + L-Aspartic
            4-semialdehyde
SUBSTRATE   L-2,4-Diaminobutyrate
            2-Oxoglutarate
PRODUCT     L-Glutamate
            L-Aspartic 4-semialdehyde
COMMENT     Involved in the formation of 1,3-diaminopropane in Haemophilus
            influenzae and Acinetobacter baumannii. A product of the ddc gene
            that also encodes L-2,4-diaminobutyrate decarboxylase in
            Acinetobacter baumannii. Differs from EC 2.6.1.46, diaminobutyrate-
            pyruvate transaminase, which has pyruvate as the amino-group
            acceptor.
GENES       SME: SMa2400(rhbA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.1.76
            ExPASy - ENZYME nomenclature database: 2.6.1.76
            WIT (What Is There) Metabolic Reconstruction: 2.6.1.76
///
ENTRY       EC 2.6.2.1
NAME        Transferred to EC 2.1.4.1
CLASS       Transferases
            Transferring nitrogenous groups
COMMENT     Transferred entry. Now EC 2.1.4.1 - Glycine amidinotransferase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.2.1
            ExPASy - ENZYME nomenclature database: 2.6.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.6.2.1
///
ENTRY       EC 2.6.3.1
NAME        Oximinotransferase
            Transoximinase
CLASS       Transferases
            Transferring nitrogenous groups
            Oximinotransferases
SYSNAME     Pyruvate-oxime:acetone oximinotransferase
REACTION    Pyruvate oxime + Acetone = Pyruvate + Acetone oxime
SUBSTRATE   Pyruvate oxime
            Acetone
            Acetaldehyde
            D-Glucose oxime
PRODUCT     Pyruvate
            Acetone oxime
            Acetaldehyde oxime
            D-Glucose
COMMENT     Acetaldehyde can act instead of acetone; D-glucose oxime can act
            instead of pyruvate oxime.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.3.1
            ExPASy - ENZYME nomenclature database: 2.6.3.1
            WIT (What Is There) Metabolic Reconstruction: 2.6.3.1
            BRENDA, the Enzyme Database: 2.6.3.1
///
ENTRY       EC 2.6.99.1
NAME        dATP(dGTP)--DNA purine transferase
CLASS       Transferases
            Transferring nitrogenous groups
            Transferring other nitrogenous groups
SYSNAME     dATP(dGTP):depurinated-DNA purinetransferase
REACTION    dATP + Depurinated DNA = D-Ribose 5-triphosphate + DNA
SUBSTRATE   dATP
            Depurinated DNA
            dGTP
PRODUCT     D-Ribose 5-triphosphate
            DNA
COMMENT     The purine residue is transferred on to the apurinic site forming
            a normal glycosylic bond. dGTP can also act as a purine donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.6.99.1
            ExPASy - ENZYME nomenclature database: 2.6.99.1
            WIT (What Is There) Metabolic Reconstruction: 2.6.99.1
            BRENDA, the Enzyme Database: 2.6.99.1
///
ENTRY       EC 2.7.1.1
NAME        Hexokinase
            Glucokinase
            Hexokinase type IV
            Hexokinase D
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-hexose 6-phosphotransferase
REACTION    ATP + D-Hexose = ADP + D-Hexose 6-phosphate;
            ITP + D-Hexose = IDP + D-Hexose 6-phosphate;
            dATP + D-Hexose = dADP + D-Hexose 6-phosphate;
            ATP + D-Glucose = ADP + D-Glucose 6-phosphate;
            ITP + D-Glucose = IDP + D-Glucose 6-phosphate;
            dATP + D-Glucose = dADP + D-Glucose 6-phosphate;
            ATP + D-Mannose = ADP + D-Mannose 6-phosphate;
            ITP + D-Mannose = IDP + D-Mannose 6-phosphate;
            dATP + D-Mannose = dADP + D-Mannose 6-phosphate;
            ATP + D-Fructose = ADP + D-Fructose 6-phosphate;
            ITP + D-Fructose = IDP + D-Fructose 6-phosphate;
            dATP + D-Fructose = dADP + D-Fructose 6-phosphate;
            ATP + D-Glucosamine = ADP + D-Glucosamine 6-phosphate;
            ITP + D-Glucosamine = IDP + D-Glucosamine 6-phosphate;
            dATP + D-Glucosamine = dADP + D-Glucosamine 6-phosphate;
            ATP + Sorbitol = ADP + Sorbitol 6-phosphate;
            ITP + Sorbitol = IDP + Sorbitol 6-phosphate;
            dATP + Sorbitol = dADP + Sorbitol 6-phosphate
SUBSTRATE   ATP
            ITP
            dATP
            D-Hexose
            D-Glucose
            D-Mannose
            D-Fructose
            D-Glucosamine
            Sorbitol
PRODUCT     ADP
            IDP
            dADP
            D-Hexose 6-phosphate
            D-Glucose 6-phosphate
            D-Mannose 6-phosphate
            D-Fructose 6-phosphate
            D-Glucosamine 6-phosphate
            Sorbitol 6-phosphate
COMMENT     D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine
            can act as acceptors; ITP and dATP can act as donors. The liver
            isoenzyme has sometimes been called glucokinase.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00522  Erythromycin biosynthesis
            PATH: MAP00530  Aminosugars metabolism
GENES       TPA: TP0505
            SCE: YFR053C(HXK1) YGL253W(HXK2)
            SPO: HSK1_2(hsk1) HXK2(hxk2)
            ATH: At4g29130(F19B15.160)
            CEL: F14B4.2
            DME: CG5443
            MMU: 96840(Ltk)
            HSA: 2645(GCK) 3098(HK1) 3099(HK2) 3101(HK3)
DISEASE     MIM: 142570  Hexokinase-3, white cell
MOTIF       PS: PS00378  [LIVM]-G-F-[TN]-F-S-[FY]-P-x(5)-[LIVM]-[DNST]-x(3)-
                         [LIVM]-x(2)-W-T-K-x-[LF]
STRUCTURES  PDB: 1BDG  1BG3  1CZA  1DGK  1GLK  1HKB  1HKC  1HKG  1IG8  1QHA  
                 2YHX  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.1
            ExPASy - ENZYME nomenclature database: 2.7.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.1
            BRENDA, the Enzyme Database: 2.7.1.1
            SCOP (Structural Classification of Proteins): 2.7.1.1
///
ENTRY       EC 2.7.1.2
NAME        Glucokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-glucose 6-phosphotransferase
REACTION    ATP + D-Glucose = ADP + D-Glucose 6-phosphate
SUBSTRATE   ATP
            D-Glucose
PRODUCT     ADP
            D-Glucose 6-phosphate
COMMENT     A group of enzymes found in invertebrates and microorganisms
            highly specific for glucose.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00522  Erythromycin biosynthesis
GENES       ECO: b2388(glk)
            ECE: Z3654(glk)
            ECS: ECs3268
            YPE: YPO2977(glk)
            HIN: HI0144
            PMU: PM1712
            XFA: XF1064 XF1460
            VCH: VC1782
            PAE: PA3193(glk)
            NME: NMB1390
            NMA: NMA1607(glk)
            HPY: HP1103(glk)
            HPJ: jhp1029
            MLO: mlr3412 mlr4640 mlr7234
            SME: SMc02835(glk)
            ATU: AGR_C_310
            CCR: CC2054 CC3167
            BSU: BG11685(glcK)
            BHA: BH0797 BH1425(glk)
            SAU: SA1377(glcK)
            SAV: SAV1536(glcK)
            LLA: L84096(glk)
            SPY: SPy1529(glcK)
            SPN: SP0668
            SPR: spr0584(glcK)
            CAC: CAC2613(glcK)
            MPU: MYPU_2280(glcK)
            SYN: sll0593(glk)
            DRA: DR2296
            TMA: TM1469
            TAC: Ta0825
            TVO: TVG0742429
            APE: APE2091
            SCE: YCL040W(GLK1)
            MMU: 95724
MOTIF       PS: PS00378  [LIVM]-G-F-[TN]-F-S-[FY]-P-x(5)-[LIVM]-[DNST]-x(3)-
                         [LIVM]-x(2)-W-T-K-x-[LF]
            PS: PS01125  [LIVM]-x(2)-G-[LIVMFCT]-G-x-[GA]-[LIVMFA]-x(8)-G-
                         x(3,5)-[GATP]-x(2)-G-[RKH]
STRUCTURES  PDB: 1GC5  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.2
            ExPASy - ENZYME nomenclature database: 2.7.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.2
            BRENDA, the Enzyme Database: 2.7.1.2
///
ENTRY       EC 2.7.1.3
NAME        Ketohexokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose 1-phosphotransferase
REACTION    ATP + D-Fructose = ADP + D-Fructose 1-phosphate
SUBSTRATE   ATP
            D-Fructose
            D-Sorbose
            D-Agatose
            5-Dehydro-D-fructose
PRODUCT     ADP
            D-Fructose 1-phosphate
COMMENT     D-Sorbose, D-agatose and 5-dehydro-D-fructose also act as
            acceptors
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       HSA: 3795(KHK)
DISEASE     MIM: 229800  Ketohexokinase (fructokinase)
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.3
            ExPASy - ENZYME nomenclature database: 2.7.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.3
            BRENDA, the Enzyme Database: 2.7.1.3
///
ENTRY       EC 2.7.1.4
NAME        Fructokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose 6-phosphotransferase
REACTION    ATP + D-Fructose = ADP + D-Fructose 6-phosphate
SUBSTRATE   ATP
            D-Fructose
PRODUCT     ADP
            D-Fructose 6-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
GENES       ECE: Z3624
            ECS: ECs3242
            PMU: PM1849
            XFA: XF1610
            VCH: VCA0656
            PAE: PA2344(mtlZ)
            MLO: mll7580
            SME: SMc02164(frk)
            CCR: CC1134
            BSU: BG12195(ydhR) BG12796(ydjE)
            BHA: BH1857
            SAU: SA1845
            SAV: SAV2024
            LLA: L117718(scrK)
            SPY: SPy1811(scrK)
            SPN: SP1721
            SPR: spr1565(scrK)
            CAC: CAC0424 CAC1523
            SYN: slr1448(cscK)
            DRA: DR0728
            TMA: TM0296
            PHO: PH1459
            PAB: PAB0482(scrk)
            SSO: SSO3195
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
            PS: PS01125  [LIVM]-x(2)-G-[LIVMFCT]-G-x-[GA]-[LIVMFA]-x(8)-G-
                         x(3,5)-[GATP]-x(2)-G-[RKH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.4
            ExPASy - ENZYME nomenclature database: 2.7.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.4
            BRENDA, the Enzyme Database: 2.7.1.4
///
ENTRY       EC 2.7.1.5
NAME        Rhamnulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L-rhamnulose 1-phosphotransferase
REACTION    ATP + L-Rhamnulose = ADP + L-Rhamnulose 1-phosphate
SUBSTRATE   ATP
            L-Rhamnulose
PRODUCT     ADP
            L-Rhamnulose 1-phosphate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b3904(rhaB)
            ECE: Z5448(rhaB)
            ECS: ECs4831
            YPE: YPO0330(rhaB)
            BSU: BG12385(yulC)
            BHA: BH1551
            SPR: spr1973(fcsK)
            TMA: TM1073
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.5
            ExPASy - ENZYME nomenclature database: 2.7.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.5
            BRENDA, the Enzyme Database: 2.7.1.5
///
ENTRY       EC 2.7.1.6
NAME        Galactokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-galactose 1-phosphotransferase
REACTION    ATP + D-Galactose = ADP + alpha-D-Galactose 1-phosphate
SUBSTRATE   ATP
            D-Galactose
            D-Galactosamine
PRODUCT     ADP
            alpha-D-Galactose 1-phosphate
            D-Galactosamine 1-phosphate
COMMENT     D-Galactosamine can also act as acceptor.
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       ECO: b0757(galK)
            ECE: Z0927(galK)
            ECS: ECs0785
            YPE: YPO1137(galK)
            HIN: HI0819(galK)
            PMU: PM1035(galK)
            VCH: VC1595
            BSU: BG10581(galK)
            BHA: BH1107(galK)
            LLA: L0028(galK)
            SPN: SP1853
            SPR: spr1668(galK)
            CAC: CAC2959(galK)
            MTU: Rv0620(galK)
            MTC: MT0648
            TPA: TP0418
            TMA: TM1190
            PHO: PH0369
            SCE: YBR020W(GAL1)
            CEL: M01D7.4
            DME: CG5288
            MMU: 95730(Glk)
            HSA: 2584(GALK1) 2585(GALK2)
DISEASE     MIM: 137028  Galactokinase-2
            MIM: 604313  Galactokinase-1
MOTIF       PS: PS00106  G-R-x-N-[LIV]-I-G-[DE]-H-x-D-Y
            PS: PS00627  [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-L-[GS]-S-S-[GSA]-[GSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.6
            ExPASy - ENZYME nomenclature database: 2.7.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.6
            BRENDA, the Enzyme Database: 2.7.1.6
///
ENTRY       EC 2.7.1.7
NAME        Mannokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-mannose 6-phosphotransferase
REACTION    ATP + D-Mannose = ADP + D-Mannose 6-phosphate
SUBSTRATE   ATP
            D-Mannose
PRODUCT     ADP
            D-Mannose 6-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.7
            ExPASy - ENZYME nomenclature database: 2.7.1.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.7
            BRENDA, the Enzyme Database: 2.7.1.7
///
ENTRY       EC 2.7.1.8
NAME        Glucosamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-glucosamine phosphotransferase
REACTION    ATP + D-Glucosamine = ADP + D-Glucosamine phosphate
SUBSTRATE   ATP
            D-Glucosamine
PRODUCT     ADP
            D-Glucosamine phosphate
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.8
            ExPASy - ENZYME nomenclature database: 2.7.1.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.8
            BRENDA, the Enzyme Database: 2.7.1.8
///
ENTRY       EC 2.7.1.9
NAME        Deleted entry
            Acetylaminodeoxyglucose kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.9
            ExPASy - ENZYME nomenclature database: 2.7.1.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.9
///
ENTRY       EC 2.7.1.10
NAME        Phosphoglucokinase
            Glucose-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-glucose-1-phosphate 6-phosphotransferase
REACTION    ATP + D-Glucose 1-phosphate = ADP + D-Glucose 1,6-bisphosphate
SUBSTRATE   ATP
            D-Glucose 1-phosphate
PRODUCT     ADP
            D-Glucose 1,6-bisphosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.10
            ExPASy - ENZYME nomenclature database: 2.7.1.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.10
            BRENDA, the Enzyme Database: 2.7.1.10
///
ENTRY       EC 2.7.1.11
NAME        6-Phosphofructokinase
            Phosphohexokinase
            Phosphofructokinase 1
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose-6-phosphate 1-phosphotransferase
REACTION    ATP + D-Fructose 6-phosphate = ADP + D-Fructose 1,6-bisphosphate;
            UTP + D-Fructose 6-phosphate = UDP + D-Fructose 1,6-bisphosphate;
            CTP + D-Fructose 6-phosphate = CDP + D-Fructose 1,6-bisphosphate;
            ITP + D-Fructose 6-phosphate = IDP + D-Fructose 1,6-bisphosphate;
            ATP + D-Tagatose 6-phosphate = ADP + D-Tagatose 1,6-bisphosphate;
            UTP + D-Tagatose 6-phosphate = UDP + D-Tagatose 1,6-bisphosphate;
            CTP + D-Tagatose 6-phosphate = CDP + D-Tagatose 1,6-bisphosphate;
            ITP + D-Tagatose 6-phosphate = IDP + D-Tagatose 1,6-bisphosphate;
            ATP + Sedoheptulose 7-phosphate = ADP +
            Sedoheptulose 1,7-bisphosphate;
            UTP + Sedoheptulose 7-phosphate = UDP +
            Sedoheptulose 1,7-bisphosphate;
            CTP + Sedoheptulose 7-phosphate = CDP +
            Sedoheptulose 1,7-bisphosphate;
            ITP + Sedoheptulose 7-phosphate = IDP +
            Sedoheptulose 1,7-bisphosphate
SUBSTRATE   ATP
            UTP
            CTP
            ITP
            D-Fructose 6-phosphate
            D-Tagatose 6-phosphate
            Sedoheptulose 7-phosphate
PRODUCT     ADP
            UDP
            CDP
            IDP
            D-Fructose 1,6-bisphosphate
            D-Tagatose 1,6-bisphosphate
            Sedoheptulose 1,7-bisphosphate
EFFECTOR    ADP
            GDP
            Phosphoenolpyruvate
COMMENT     D-Tagatose 6-phosphate and sedoheptulose 7-phosphate can act as
            acceptors; UTP, CTP, and ITP can act as donors. Not identical with
            EC 2.7.1.105 (EC 2.7.1.105 6-Phosphofructo-2-kinase)
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
GENES       ECO: b1723(pfkB) b3916(pfkA)
            ECE: Z2752(pfkB) Z5460(pfkA)
            ECS: ECs2429 ECs4841
            YPE: YPO0078(pfkA)
            HIN: HI0982(pfkA)
            PMU: PM0069(pfkA)
            XFA: XF0274
            VCH: VC2689
            BUC: BU305(pfkA)
            MLO: mll5025
            BSU: BG12644(pfk)
            BHA: BH3164(pfk)
            SAU: SA1521(pfk)
            SAV: SAV1684(pfk)
            LLA: L0002(pfk)
            SPY: SPy1283(pfk)
            SPN: SP0896
            SPR: spr0796(pfkA)
            CAC: CAC0517(pfk)
            MGE: MG215(pfka)
            MPN: H10_orf328(pfk)
            MPU: MYPU_6010(pfk)
            UUR: UU185(pfkA)
            MTU: Rv2029c(pfkB) Rv3010c(pfkA)
            MTC: MT2088 MT3090
            MLE: ML1701(pfkA)
            SYN: sll0745(pfkA) sll1196(pfkA)
            DRA: DR0635
            AAE: aq_1708(pfkA)
            TMA: TM0209 TM0289
            SCE: YGR240C(PFK1) YMR205C(PFK2)
            SPO: SPBC16H5.02(spbc16h5.02)
            CEL: C50F4.2 Y71H10A.1
            DME: CG4001(Pfk) CG4001_1(Pfk)
            MMU: 97547(Pfkl)
            HSA: 5211(PFKL) 5213(PFKM) 5214(PFKP) 5215(PFKX)
DISEASE     MIM: 171840  Phosphofructokinase, platelet type
            MIM: 171860  Phosphofructokinase, liver type
            MIM: 232800  Phosphofructokinase, muscle type
MOTIF       PS: PS00433  [RK]-x(4)-G-H-x-Q-[QR]-G-G-x(5)-D-R
            PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
STRUCTURES  PDB: 6PFK  4PFK  1PFK  2PFK  3PFK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.11
            ExPASy - ENZYME nomenclature database: 2.7.1.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.11
            BRENDA, the Enzyme Database: 2.7.1.11
            SCOP (Structural Classification of Proteins): 2.7.1.11
///
ENTRY       EC 2.7.1.12
NAME        Gluconokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:2-dehydro-D-gluconate 6-phosphotransferase
REACTION    ATP + D-Gluconate = ADP + 6-Phospho-D-gluconate
SUBSTRATE   ATP
            D-Gluconate
PRODUCT     ADP
            6-Phospho-D-gluconate
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b3437(gntK) b4268(gntV)
            ECE: Z4805(gntK)
            ECS: ECs4286
            YPE: YPO2540(idnK) YPO3953
            PMU: PM0792(glk)
            VCH: VC0287
            PAE: PA2321
            NME: NMB2028
            NMA: NMA0412
            MLO: mll1676
            SME: SMb21119(gntK)
            BSU: BG10649(gntK)
            BHA: BH2676(gntK)
            SAU: SA2294(gntK)
            SAV: SAV2489(gntK)
            LLA: L52019(gntK)
            DRA: DR1910
            AAE: aq_1484 aq_288
            TMA: TM0443
            SCE: YDR248C
            SPO: SPAC4G9.12(spac4g9.12)
MOTIF       PS: PS00445  [GSA]-x-[LIVMFYW]-x-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                         x(2)-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
            PS: PS00933  [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-x-W-[LIVMF]-x-
                         [DENQTKR]-[ENQH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.12
            ExPASy - ENZYME nomenclature database: 2.7.1.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.12
            BRENDA, the Enzyme Database: 2.7.1.12
///
ENTRY       EC 2.7.1.13
NAME        Dehydrogluconokinase
            Ketogluconokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:2-dehydro-D-gluconate 6-phosphate
REACTION    ATP + 2-Dehydro-D-gluconate = ADP +
            6-Phospho-2-dehydro-D-gluconate
SUBSTRATE   ATP
            2-Dehydro-D-gluconate
PRODUCT     ADP
            6-Phospho-2-dehydro-D-gluconate
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.13
            ExPASy - ENZYME nomenclature database: 2.7.1.13
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.13
            BRENDA, the Enzyme Database: 2.7.1.13
///
ENTRY       EC 2.7.1.14
NAME        Sedoheptulokinase
            Heptulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:sedoheptulose 7-phosphate
REACTION    ATP + Sedoheptulose = ADP + Sedoheptulose 7-phosphate
SUBSTRATE   ATP
            Sedoheptulose
PRODUCT     ADP
            Sedoheptulose 7-phosphate
PATHWAY     PATH: MAP00710  Carbon fixation
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.14
            ExPASy - ENZYME nomenclature database: 2.7.1.14
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.14
            BRENDA, the Enzyme Database: 2.7.1.14
///
ENTRY       EC 2.7.1.15
NAME        Ribokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-ribose 5-phosphotransferase
REACTION    ATP + D-Ribose = ADP + D-Ribose 5-phosphate
SUBSTRATE   ATP
            D-Ribose
            2-Deoxy-D-ribose
PRODUCT     ADP
            D-Ribose 5-phosphate
            2-Deoxy-D-ribose 5-phosphate
COMMENT     2-Deoxy-D-ribose can also act as an acceptor
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b3752(rbsK)
            ECE: Z5253(rbsK)
            ECS: ECs4694
            YPE: YPO0008(rbsK) YPO3621
            HIN: HI0505(rbsK)
            PMU: PM0152(rbsK)
            XFA: XF0366
            VCH: VCA0131
            PAE: PA1950(rbsK)
            MLO: mll7662 mlr3185 mlr8492
            SME: SMc01103(rbsK)
            CCR: CC0950
            BSU: BG10877(rbsK)
            BHA: BH3728(rbsK)
            SAU: SA0258(rbsK)
            SAV: SAV0261(rbsK)
            LLA: L86157(rbsK)
            MTU: Rv2436(rbsK)
            MTC: MT2511
            DRA: DRA0055
            TMA: TM0960
            MJA: MJ0406
            MTH: MTH1544 MTH1841 MTH404
            AFU: AF0356 AF0401
            HAL: VNG1851G(suk)
            TAC: Ta0880
            TVO: TVG1031550
            PHO: PH1845
            PAB: PAB0280(rbsk)
            APE: APE0012 APE2106
            SSO: SSO0004(rbsK-1) SSO2449(rbsK-2)
            STO: ST0574
            SCE: YCR036W(RBK1)
            SPO: SPBC16G5.02C(spbc16g5.02c)
            CEL: F07A11.5
            DME: CG13369(EG:115C2.1) CG17010
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
STRUCTURES  PDB: 1RK2  1RKS  1RKD  1RKA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.15
            ExPASy - ENZYME nomenclature database: 2.7.1.15
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.15
            BRENDA, the Enzyme Database: 2.7.1.15
            SCOP (Structural Classification of Proteins): 2.7.1.15
///
ENTRY       EC 2.7.1.16
NAME        Ribulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L(or D)-ribulose 5-phosphotransferase
REACTION    ATP + L-Ribulose or D-Ribulose = ADP + L-Ribulose 5-phosphate or 
            D-Ribulose 5-phosphate
SUBSTRATE   ATP
            D-Ribulose
            L-Ribulose
            Ribitol
            L-Arabinitol
PRODUCT     ADP
            D-Ribulose 5-phosphate
            L-Ribulose 5-phosphate
            Ribitol 5-phosphate
            L-Arabinitol 5-phosphate
COMMENT     Ribitol and L-arabinitol can also act as acceptors
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b0063(araB)
            ECE: Z0072(araB)
            ECS: ECs0067
            YPE: YPO2254(araB)
            BSU: BG11905(araB)
            BHA: BH1872(araB)
            SAU: SA0510(araB)
            SAV: SAV0541(araB)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.16
            ExPASy - ENZYME nomenclature database: 2.7.1.16
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.16
            BRENDA, the Enzyme Database: 2.7.1.16
///
ENTRY       EC 2.7.1.17
NAME        Xylulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-xylulose 5-phosphotransferase
REACTION    ATP + D-Xylulose = ADP + D-Xylulose 5-phosphate
SUBSTRATE   ATP
            D-Xylulose
PRODUCT     ADP
            D-Xylulose 5-phosphate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b3564(xylB)
            ECE: Z4989(xylB)
            ECS: ECs4447
            YPE: YPO4039(xylB)
            HIN: HI1113(xylB)
            PMU: PM1371
            PAE: PA2343(mtlY)
            MLO: mlr5033
            SME: SMc03164(xylB)
            BSU: BG10807(xylB)
            BHA: BH2756(xylB)
            LLA: L0231(xylB)
            CAC: CAC2612(xylB)
            MTU: Rv0729(xylB)
            MTC: MT0754
            TMA: TM0116
            AFU: AF1324
MOTIF       PS: PS00445  [GSA]-x-[LIVMFYW]-x-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                         x(2)-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
            PS: PS00933  [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-x-W-[LIVMF]-x-
                         [DENQTKR]-[ENQH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.17
            ExPASy - ENZYME nomenclature database: 2.7.1.17
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.17
            BRENDA, the Enzyme Database: 2.7.1.17
///
ENTRY       EC 2.7.1.18
NAME        Phosphoribokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-ribose-5-phosphate 1-phosphotransferase
REACTION    ATP + D-Ribose 5-phosphate = ADP + D-Ribose 1,5-bisphosphate
SUBSTRATE   ATP
            D-Ribose 5-phosphate
PRODUCT     ADP
            D-Ribose 1,5-bisphosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.18
            ExPASy - ENZYME nomenclature database: 2.7.1.18
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.18
            BRENDA, the Enzyme Database: 2.7.1.18
///
ENTRY       EC 2.7.1.19
NAME        Phosphoribulokinase
            Phosphopentokinase
            Ribulose-5-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-ribulose-5-phosphate 1-phosphotransferase
REACTION    ATP + D-Ribulose 5-phosphate = ADP + D-Ribulose 1,5-bisphosphate
SUBSTRATE   ATP
            D-Ribulose 5-phosphate
PRODUCT     ADP
            D-Ribulose 1,5-bisphosphate
PATHWAY     PATH: MAP00710  Carbon fixation
GENES       ECO: b3355(prkB)
            ECE: Z4716(prkB)
            ECS: ECs4206
            YPE: YPO0178(prk)
            VCH: VC2613
            SME: SMb20201(cbbP)
            SYN: sll1525(prk)
MOTIF       PS: PS00567  K-[LIVM]-x-R-D-x(3)-R-G-x-[ST]-x-E
STRUCTURES  PDB: 1A7J  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.19
            ExPASy - ENZYME nomenclature database: 2.7.1.19
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.19
            BRENDA, the Enzyme Database: 2.7.1.19
            SCOP (Structural Classification of Proteins): 2.7.1.19
///
ENTRY       EC 2.7.1.20
NAME        Adenosine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:adenosine 5'-phosphotransferase
REACTION    ATP + Adenosine = ADP + AMP
SUBSTRATE   ATP
            Adenosine
            2-Aminoadenosine
PRODUCT     ADP
            AMP
            2-AminoAMP
COMMENT     2-Aminoadenosine can also act as acceptor.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       SCE: YJR105W
            SPO: SPCC338.14(spcc338.14)
            CEL: R07H5.8
            DME: CG11255 CG11255_1 CG1851 CG3809
            MMU: 87930(Adk)
            HSA: 132(ADK)
DISEASE     MIM: 102750  Adenosine kinase
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
STRUCTURES  PDB: 1DH0  1DGY  1DGM  1BX4  1DH2  1DH1  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.20
            ExPASy - ENZYME nomenclature database: 2.7.1.20
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.20
            BRENDA, the Enzyme Database: 2.7.1.20
            SCOP (Structural Classification of Proteins): 2.7.1.20
///
ENTRY       EC 2.7.1.21
NAME        Thymidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:thymidine 5'-phosphotransferase
REACTION    ATP + Thymidine = ADP + Thymidine 5'-phosphate
SUBSTRATE   ATP
            dGTP
            Thymidine
            Deoxythymidine
            Deoxyuridine
PRODUCT     ADP
            dGDP
            Thymidine 5'-phosphate
            Deoxythymidine 5'-phosphate
            Deoxyuridine 5'-phosphate
COMMENT     Deoxyuridine can also act as acceptor, and dGTP as a donor. The
            deoxypyrimidine kinase complex induced by Herpes simplex virus
            catalyses this reaction as well as those of EC 2.7.1.114,
            2.7.1.118 and 2.7.4.9.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b1238(tdk)
            ECE: Z2015(tdk)
            ECS: ECs1740
            YPE: YPO2176(tdk)
            HIN: HI0529(tdk)
            PMU: PM1236(tdk)
            VCH: VC1167
            MLO: mlr2747
            SME: SMc02736(tdk)
            BSU: BG10419(tdk)
            BHA: BH3779(tdk)
            SAU: SA1921(tdk)
            SAV: SAV2106(tdk)
            LLA: L184871(yfiG)
            SPY: SPy1140(tdk2)
            SPN: SP1018
            SPR: spr0922(tdk)
            CAC: CAC2887(tdk)
            MGE: MG034(tdk)
            MPN: B01_orf191
            MPU: MYPU_1450(tdk)
            UUR: UU594(tdk)
            BBU: BB0791(tdk)
            DRA: DR1984
            TMA: TM0401
            HAL: VNG1515G(tdk)
            TAC: Ta1214
            CEL: Y43C5A.5
            DME: CG5452(dnk)
            MMU: 98763(Tk1)
            HSA: 7083(TK1) 7084(TK2)
DISEASE     MIM: 188300  Thymidine kinase-1
MOTIF       PS: PS00603  [GA]-x(1,2)-[DE]-x-Y-x-[STAP]-x-C-[NKR]-x-[CH]-
                         [LIVMFYWH]
STRUCTURES  PDB: 1KI3  1KI2  1E2P  1E2N  1E2M  1E2L  1E2K  1E2J  1E2I  1E2H  
                 1KI4  1KI6  1KI7  1KI8  1KIM  1QHI  2VTK  3VTK  1VTK  2KI5  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.21
            ExPASy - ENZYME nomenclature database: 2.7.1.21
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.21
            BRENDA, the Enzyme Database: 2.7.1.21
            SCOP (Structural Classification of Proteins): 2.7.1.21
///
ENTRY       EC 2.7.1.22
NAME        Ribosylnicotinamide kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:N-ribosylnicotinamide 5'-phosphotransferase
REACTION    ATP + N-Ribosylnicotinamide = ADP + Nicotinamide D-ribonucleotide
SUBSTRATE   ATP
            N-Ribosylnicotinamide
PRODUCT     ADP
            Nicotinamide D-ribonucleotide
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.22
            ExPASy - ENZYME nomenclature database: 2.7.1.22
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.22
            BRENDA, the Enzyme Database: 2.7.1.22
///
ENTRY       EC 2.7.1.23
NAME        NAD+ kinase
            DPN kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:NAD+ 2'-phosphotransferase
REACTION    ATP + NAD+ = ADP + NADP+
SUBSTRATE   ATP
            NAD+
PRODUCT     ADP
            NADP+
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b2615(yfjB)
            ECE: Z3908(yfjB)
            ECS: ECs3477
            HIN: HI0072
            PMU: PM0333
            XFA: XF2090
            VCH: VC0853
            PAE: PA3088
            BUC: BU185(yfjB)
            NME: NMB0807
            NMA: NMA1017
            HPY: HP1394
            HPJ: jhp1433
            CJE: Cj0641
            RPR: RP440
            BSU: BG13143(yjbN)
            BHA: BH2848
            SAU: SA0865
            SAV: SAV0992
            LLA: L166614(ydgJ)
            SPY: SPy1126
            SPN: SP1098
            SPR: spr1005
            CAC: CAC2075
            MGE: MG128
            MPN: A65_orf259
            UUR: UU177
            MTU: Rv1695
            MTC: MT1734
            MLE: ML1359
            BBU: BB0311
            TPA: TP0441
            SYN: sll1415 slr0400
            AAE: aq_909
            TMA: TM1733
            MJA: MJ0917
            MTH: MTH872
            AFU: AF2373
            HAL: VNG1900C
            TAC: Ta0622
            PHO: PH1074
            PAB: PAB1756
            APE: APE1104
            HSA: 65220(FLJ13052)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.23
            ExPASy - ENZYME nomenclature database: 2.7.1.23
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.23
            BRENDA, the Enzyme Database: 2.7.1.23
///
ENTRY       EC 2.7.1.24
NAME        Dephospho-CoA kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:dephospho-CoA 3'-phosphotransferase
REACTION    ATP + Dephospho-CoA = ADP + CoA
SUBSTRATE   ATP
            Dephospho-CoA
PRODUCT     ADP
            CoA
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b0103(yacE)
            ECE: Z0113(yacE)
            ECS: ECs0107
            HIN: HI0890
            PMU: PM0088
            XFA: XF2536
            VCH: VC2427
            PAE: PA4529
            BUC: BU203(yacE)
            NMA: NMA2157
            HPY: HP0831
            HPJ: jhp0770
            CJE: Cj1530
            RPR: RP731
            MLO: mlr4493
            SME: SMc02790
            CCR: CC0004
            BSU: BG13824(coaE)
            BHA: BH3150
            SAU: SA1511
            SAV: SAV1674
            LLA: L59930(yggA)
            SPY: SPy0498
            SPN: SP0971
            SPR: spr0873
            CAC: CAC1099
            MGE: MG264
            MPN: A19_orf200
            MPU: MYPU_7210
            MTU: Rv1631
            MTC: MT1667
            MLE: ML1383
            CTR: CT492
            CMU: TC0779
            CPN: CPn0611
            CPJ: yacE
            BBU: BB0547
            TPA: TP0296
            SYN: slr0553
            DRA: DR1892
            AAE: aq_1985
            TMA: TM1387
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.24
            ExPASy - ENZYME nomenclature database: 2.7.1.24
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.24
            BRENDA, the Enzyme Database: 2.7.1.24
///
ENTRY       EC 2.7.1.25
NAME        Adenylylsulfate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:adenylylsulfate 3'-phosphotransferase
REACTION    ATP + Adenylylsulfate = ADP + 3'-Phosphoadenylylsulfate
SUBSTRATE   ATP
            Adenylylsulfate
PRODUCT     ADP
            3'-Phosphoadenylylsulfate
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b2750(cysC)
            ECE: Z4058(cysC)
            ECS: ECs3604
            YPE: YPO3364(cysC)
            XFA: XF1501
            VCH: VC2558
            PAE: PA1393(cysC) PA4442(cysN)
            BUC: BU422(cysC)
            CJE: Cj1415c(cysC)
            MLO: mlr7576
            SME: SMa0857(nodQ1) SMb21224(nodQ2)
            CCR: CC1482
            BSU: BG13105(yisZ) BG13379(cycC)
            BHA: BH1489 BH3385
            CAC: CAC0103(cysC) CAC0110(cysN)
            MTU: Rv1286(cysN)
            MTC: MT1324
            SYN: slr0676(cysC)
            DRA: DRA0014
            AAE: aq_1081(cysD)
            AFU: AF0288(cysC)
            PAB: PAB0781(cysC)
            APE: APE1195
            SCE: YKL001C(MET14)
            SPO: SPAC1782.11(spac1782.11)
            ATH: At2g14750(F26C24.11) At4g39940(T5J17.110)
            CEL: T14G10.1
            DME: CG8363(Paps)
            HSA: 9060(PAPSS2) 9061(PAPSS1)
STRUCTURES  PDB: 1D6J  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.25
            ExPASy - ENZYME nomenclature database: 2.7.1.25
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.25
            BRENDA, the Enzyme Database: 2.7.1.25
            SCOP (Structural Classification of Proteins): 2.7.1.25
///
ENTRY       EC 2.7.1.26
NAME        Riboflavin kinase
            Flavokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:riboflavin 5'-phosphotransferase
REACTION    ATP + Riboflavin = ADP + FMN
SUBSTRATE   ATP
            Riboflavin
PRODUCT     ADP
            FMN
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0025(ribF)
            ECE: Z0029(ribF)
            ECS: ECs0028
            YPE: YPO0474(ribF)
            HIN: HI0963(ribF)
            PMU: PM1661(ribF)
            XFA: XF2419
            VCH: VC0681
            PAE: PA4561(ribF)
            BUC: BU150(ribF)
            NME: NMB1834
            NMA: NMA0621(ribF)
            HPY: HP1087(ribC)
            HPJ: jhp0338
            CJE: Cj0589(ribF)
            MLO: mlr8243
            SME: SMc00909(ribF)
            ATU: AGR_C_1228
            CCR: CC0703
            BSU: BG11495(ribC)
            BHA: BH2409(ribC)
            SAU: SA1115(ribC)
            SAV: SAV1260(ribC)
            LLA: L0167(ribC)
            SPY: SPy1250(mreA)
            CAC: CAC1806
            MGE: MG145(ribf)
            MPN: VXpSPT7_orf269(yaaC)
            MPU: MYPU_5480(ribF)
            UUR: UU355(ribF)
            MTU: Rv2786c(ribF)
            MTC: MT2856
            MLE: ML0852(ribF)
            CTR: CT093
            CMU: TC0368
            CPN: CPn0320
            CPA: CP0437
            CPJ: ribF
            TPA: TP0888
            SYN: slr1882(ribF)
            DRA: DR1008
            AAE: aq_139(ribF)
            TMA: TM0857
            SCE: YDR236C(FMN1)
            SPO: SPCC18.16C(spcc18.16c)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.26
            ExPASy - ENZYME nomenclature database: 2.7.1.26
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.26
            BRENDA, the Enzyme Database: 2.7.1.26
///
ENTRY       EC 2.7.1.27
NAME        Erythritol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:erythritol 4-phosphotransferase
REACTION    ATP + Erythritol = ADP + D-Erythritol 4-phosphate
SUBSTRATE   ATP
            Erythritol
PRODUCT     ADP
            D-Erythritol 4-phosphate
GENES       SME: SMc01623(eriA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.27
            ExPASy - ENZYME nomenclature database: 2.7.1.27
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.27
            BRENDA, the Enzyme Database: 2.7.1.27
///
ENTRY       EC 2.7.1.28
NAME        Triokinase
            Triose kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-glyceraldehyde 3-phosphotransferase
REACTION    ATP + D-Glyceraldehyde = ADP + D-Glyceraldehyde 3-phosphate
SUBSTRATE   ATP
            D-Glyceraldehyde
PRODUCT     ADP
            D-Glyceraldehyde 3-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.28
            ExPASy - ENZYME nomenclature database: 2.7.1.28
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.28
            BRENDA, the Enzyme Database: 2.7.1.28
///
ENTRY       EC 2.7.1.29
NAME        Glycerone kinase
            Dihydroxyacetone kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:glycerone phosphotransferase
REACTION    ATP + Glycerone = ADP + Glycerone phosphate
SUBSTRATE   ATP
            Glycerone
PRODUCT     ADP
            Glycerone phosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       YPE: YPO3350(dhaK)
            MLO: mll5296
            SME: SMb20767(dak)
            SCE: YFL053W(DAK2) YML070W(DAK1)
            SPO: DAK1(dak1) SPAC22A12.11(spac22a12.11)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.29
            ExPASy - ENZYME nomenclature database: 2.7.1.29
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.29
            BRENDA, the Enzyme Database: 2.7.1.29
///
ENTRY       EC 2.7.1.30
NAME        Glycerol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:glycerol 3-phosphotransferase
REACTION    ATP + Glycerol = ADP + sn-Glycerol 3-phosphate
SUBSTRATE   ATP
            UTP
            Glycerol
            L-Glyceraldehyde
            Glycerone
PRODUCT     ADP
            sn-Glycerol 3-phosphate
COMMENT     Glycerone and L-glyceraldehyde can act as acceptors; UTP (and,
            in the case of the yeast enzyme, ITP and GTP) can act as donors.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b3926(glpK)
            ECE: Z5471(glpK)
            ECS: ECs4851
            YPE: YPO0090(glpK') YPO3312
            HIN: HI0691(glpK)
            PMU: PM1446(glpK)
            XFA: XF2268
            VCH: VCA0744
            PAE: PA1487 PA3579 PA3582(glpK)
            MLO: mll0700
            SME: SMb21009(glpK)
            CCR: CC1223
            BSU: BG10187(glpK)
            BHA: BH1093(glpK)
            SAU: SA1141(glpK)
            SAV: SAV1287(glpK)
            LLA: L0014(glpK)
            SPY: SPy1684(glpK)
            SPN: SP2186
            SPR: spr1991(glpK)
            CAC: CAC1321(glpK)
            MGE: MG038(glpK)
            MPN: D09_orf508(glpK)
            MPU: MYPU_2210(glpK)
            MTU: Rv3696c(glpK)
            MTC: MT3798
            MLE: ML2314(glpK)
            BBU: BB0241(glpK)
            SYN: slr1672(glpK)
            DRA: DR1928
            AAE: aq_434(glpK)
            TMA: TM0952 TM1430
            AFU: AF0866(glpK)
            HAL: VNG1967G(glpK)
            TAC: Ta1096
            TVO: TVG1192129
            PAB: PAB2406(glpk)
            APE: APE0306
            SSO: SSO1600 SSO2133(glpK-2)
            SCE: YHL032C(GUT1)
            CEL: C55B6.1 R11F4.1
            DME: CG1271 CG18374 CG7995 CG7995_1
            MMU: 106594(Gyk)
            HSA: 2710
DISEASE     MIM: 307030  Glycerol kinase deficiency
MOTIF       PS: PS00445  [GSA]-x-[LIVMFYW]-x-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                         x(2)-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
            PS: PS00933  [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-x-W-[LIVMF]-x-
                         [DENQTKR]-[ENQH]
STRUCTURES  PDB: 1BU6  1BWF  1GLA  1GLB  1GLC  1GLD  1GLE  1GLF  1GLJ  1GLL  
                 1BO5  1BOT  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.30
            ExPASy - ENZYME nomenclature database: 2.7.1.30
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.30
            BRENDA, the Enzyme Database: 2.7.1.30
            SCOP (Structural Classification of Proteins): 2.7.1.30
///
ENTRY       EC 2.7.1.31
NAME        Glycerate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:(R)-glycerate 3-phosphotransferase
REACTION    ATP + (R)-Glycerate = ADP + D-Glycerate 3-phosphate
SUBSTRATE   ATP
            (R)-Glycerate
PRODUCT     ADP
            D-Glycerate 3-phosphate
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b0514(ybbZ) b3124(yhaD)
            ECE: Z0669(ybbZ) Z4476(yhaD)
            ECS: ECs0576 ECs4002
            YPE: YPO3980(glxK)
            HIN: HI0091
            NME: NMB1268
            NMA: NMA1473
            BSU: BG11103(yxaA)
            BHA: BH0555
            SAU: SA2220
            SAV: SAV2416
            SPN: SP1126
            CAC: CAC2834
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.31
            ExPASy - ENZYME nomenclature database: 2.7.1.31
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.31
            BRENDA, the Enzyme Database: 2.7.1.31
///
ENTRY       EC 2.7.1.32
NAME        Choline kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:choline phosphotransferase
REACTION    ATP + Choline = ADP + Choline phosphate
SUBSTRATE   ATP
            Choline
            Ethanolamine
PRODUCT     ADP
            Choline phosphate
            Ethanolamine phosphate
COMMENT     Ethanolamine and its methyl and ethyl derivatives can also act as
            acceptors.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       SCE: YLR133W(CKI1)
            SPO: SPAC13G7.12C(spac13g7.12c)
            CEL: C52B9.1
            HSA: 1119(CHK) 1120(CHKL)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.32
            ExPASy - ENZYME nomenclature database: 2.7.1.32
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.32
            BRENDA, the Enzyme Database: 2.7.1.32
///
ENTRY       EC 2.7.1.33
NAME        Pantothenate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pantothenate 4'-phosphotransferase
REACTION    ATP + Pantothenate = ADP + D-4'-Phosphopantothenate
SUBSTRATE   ATP
            Pantothenate
PRODUCT     ADP
            D-4'-Phosphopantothenate
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b3974(coaA)
            ECE: Z5545(coaA)
            ECS: ECs4901
            YPE: YPO3758(coaA)
            HIN: HI0631(coaA)
            PMU: PM1747(coaA)
            VCH: VC0320
            MLO: mlr5019
            SME: SMc02567(coaA)
            BSU: BG11748(coaA)
            BHA: BH2875
            LLA: L66222(coaA)
            SPY: SPy1233(coaA)
            SPN: SP0839
            SPR: spr0741(coaA)
            MTU: Rv1092c(coaA)
            MTC: MT1124
            MLE: ML1954(coaA)
STRUCTURES  PDB: 1ESM  1ESN  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.33
            ExPASy - ENZYME nomenclature database: 2.7.1.33
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.33
            BRENDA, the Enzyme Database: 2.7.1.33
            SCOP (Structural Classification of Proteins): 2.7.1.33
///
ENTRY       EC 2.7.1.34
NAME        Pantetheine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pantetheine 4'-phosphotransferase
REACTION    ATP + Pantetheine = ADP + Pantetheine 4'-phosphate
SUBSTRATE   ATP
            Pantetheine
PRODUCT     ADP
            Pantetheine 4'-phosphate
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.34
            ExPASy - ENZYME nomenclature database: 2.7.1.34
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.34
            BRENDA, the Enzyme Database: 2.7.1.34
///
ENTRY       EC 2.7.1.35
NAME        Pyridoxal kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pyridoxal 5'-phosphotransferase
REACTION    ATP + Pyridoxal = ADP + Pyridoxal 5'-phosphate
SUBSTRATE   ATP
            Pyridoxal
            Pyridoxine
            Pyridoxamine
PRODUCT     ADP
            Pyridoxal 5'-phosphate
            Pyridoxal phosphate
            Pyridoxine phosphate
            Pyridoxamine phosphate
COMMENT     Pyridoxine, pyridoxamine and various derivatives can also act as
            acceptors.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
GENES       ECO: b1636(pdxY) b2418(pdxK)
            ECE: Z2648(pdxY) Z3684(pdxK)
            ECS: ECs2345 ECs3290
            YPE: YPO2368(pdxY)
            HIN: HI0405(pdxY)
            PMU: PM0290(pdxY)
            PAE: PA5516(pdxY)
            MLO: mlr4132
            SME: SMc04084(pdxK)
            CCR: CC0256
            CAC: CAC1622
            DRA: DRA0184
            CEL: F57C9.1
            HSA: 8566(PDXK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.35
            ExPASy - ENZYME nomenclature database: 2.7.1.35
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.35
            BRENDA, the Enzyme Database: 2.7.1.35
///
ENTRY       EC 2.7.1.36
NAME        Mevalonate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:(R)-mevalonate 5-phosphotransferase
REACTION    ATP + (R)-Mevalonate = ADP + (R)-5-Phosphomevalonate
SUBSTRATE   ATP
            (R)-Mevalonate
            CTP
            GTP
            UTP
PRODUCT     ADP
            (R)-5-Phosphomevalonate
            CDP
            GDP
            UDP
COMMENT     CTP, GTP and UTP can also act as donors.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       CJE: Cj1425c
            SAU: SA0547(mvaK1)
            SAV: SAV0579
            LLA: L7866(yeaG)
            SPY: SPy0876(mvaK1)
            SPN: SP0381
            SPR: spr0338(mvk)
            BBU: BB0688
            MJA: MJ1087
            MTH: MTH46
            AFU: AF2289(mvk)
            HAL: VNG1145G(mvk)
            PHO: PH1625
            PAB: PAB0372(mvk)
            APE: APE2439
            SSO: SSO0383
            SCE: YMR208W(ERG12)
            SPO: SPAC13G6.11C(spac13g6.11c)
            ATH: At5g27450(F21A20.160)
            DME: CG16804
            HSA: 4598(MVK)
DISEASE     MIM: 251170  Mevalonate kinase
MOTIF       PS: PS00627  [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-L-[GS]-S-S-[GSA]-[GSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.36
            ExPASy - ENZYME nomenclature database: 2.7.1.36
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.36
            BRENDA, the Enzyme Database: 2.7.1.36
///
ENTRY       EC 2.7.1.37
NAME        Protein kinase
            Phospharylase b kinase kinase
            Glycogen synthase a kinase
            Hydroxyalkyl-protein kinase
            Serine(threonine) protein kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protein phosphotransferase
REACTION    ATP + a Protein = ADP + a Phosphoprotein
SUBSTRATE   ATP
            Protein
PRODUCT     ADP
            Phosphoprotein
INHIBITOR   Debromoaplysiatoxin
            Bryostatins
            Teleocidin B-1
            12-O-Tetradecanoylphorbol 13-acetate
COMMENT     A group of enzymes which are under review by NC-IUBMB.
            Other present entries are EC 2.7.1.38, 2.7.1.70, 2.7.1.99,
            2.7.1.109-112, 2.7.1.115-6, 2.7.1.123-6, 2.7.1.135 and 2.7.1.141.
            Some enzymes are activated by cyclic GMP, but not by cyclic AMP,
            and some enzymes by neither.
PATHWAY     PATH: MAP04320  Dorso-Ventral axis formation
GENES       BSU: BG13391(prkC)
            BHA: BH2504
            SAU: SA1063
            SAV: SAV1207
            LLA: L138452(pknB)
            SPY: SPy1625
            SPN: SP1732
            CAC: CAC1728
            MPN: K04_orf389
            MTU: Rv0410c(pknG)
            MTC: MT0423
            SYN: sll1575(spkA) slr0152 slr1225(pknA) slr1443(pknA)
            AAE: aq_576(stpK)
            MTH: MTH1485 MTH283
            SCE: YGL019W(CKB1) YHR205W(SCH9) YIL033C(SRA1) YIL035C(CKA1)
                 YJL164C(SRA3) YKL166C(TPK3) YOR039W(CKB2) YOR061W(CKA2)
                 YPL203W(PKA3)
            SPO: CKA1(cka1) CKB1(ckb1) PKA1(pka1) SCK1(sck1)
                 SPBC2G5.02C(spbc2g5.02c)
            ATH: At2g23080(F21P24.14) At2g44680(F16B22.22) At4g17640(dl4855w)
            CEL: B0205.7 kin-1 kin-10 kin-2
            DME: CG10033 CG10033_2(for) CG10498(cdc2c) CG10572(Cdk8)
                 CG10579(Eip63E) CG10637(Nak) CG10895(lok) CG11420(EG:8D8.5)
                 CG12066(Pka-C2) CG12072(wts) CG12244(lic) CG12306(polo)
                 CG13591(Ssl) CG1362(cdc2rk) CG14026(tkv) CG15224(CkIIbeta)
                 CG15793(Dsor1) CG15862 CG1609(Gcn2) CG17216(KP78b)
                 CG17299(SNF4Agamma) CG17520(CkIIalpha) CG18582(mbt)
                 CG1891(sax) CG1954(Pkc98E) CG2028(CkIalpha) CG2621(sgg)
                 CG2845(phl) CG2899(ksr) CG3051 CG3068(aur) CG3263(Pka-R1)
                 CG3319(Cdk7) CG3324(Pkg21D) CG4006_1(Akt1) CG4012(gek)
                 CG4201(IKK) CG4268(Pitslre) CG4290(EG:22E5.8) CG4379(Pka-C1)
                 CG4720(Pk92B) CG5072(Cdk4/6) CG5125(ninaC) CG5125_1(ninaC)
                 CG5179(Cdk9) CG5363(cdc2) CG5475(Mpk2) CG5974(pll) CG6027(cdi)
                 CG6297(JIL-1) CG6453 CG6518(inaC) CG6551 CG6620(ial) CG6622
                 CG6622_1 CG6715(KP78a) CG6929 CG7001(Bin4) CG7393(p38b)
                 CG7838(Bub1) CG7892(nmo) CG7904(put) CG8201(par-1)
                 CG8203(Cdk5) CG8224(babo) CG8637(Ndr) CG8914(CkIIbeta2)
                 CG9738(Mkk4) CG9774(Rhk)
            MMU: 88548(Csnk2b) 97594(Pkacb) 98729(Tgfbr2)
            HSA: 10087(COL4A3BP) 10494(STK25) 1457(CSNK2A1) 1459(CSNK2A2)
                 1460(CSNK2B) 207(AKT1) 26576(STK23) 2932(GSK3B) 472(ATM)
                 5566(PRKACA) 5567(PRKACB) 5568(PRKACG) 5573(PRKAR1A)
                 5575(PRKAR1B) 5576(PRKAR2A) 5577(PRKAR2B) 5587(PRKCM)
                 5589(PRKCSH) 5591(PRKDC) 5592(PRKG1) 5593(PRKG2) 657(BMPR1A)
                 6788(STK3) 6789(STK4) 6793(STK10) 7046(TGFBR1) 7048(TGFBR2)
                 8576(STK16) 8999(CDKL2) 90(ACVR1) 9020(MAP3K14) 91(ACVR1B)
                 94(ACVRL1)
DISEASE     MIM: 102576  Activin A receptor, type I
            MIM: 115441  Casein kinase-2, beta polypeptide
            MIM: 115442  Casein kinase-2, alpha-prime polypeptide
            MIM: 164730  Murine thymoma viral (v-akt) oncogene homolog-1
            MIM: 176892  Protein kinase, cAMP-dependent, catalytic, beta
            MIM: 176893  Protein kinase, cAMP-dependent, catalytic, gamma
            MIM: 176894  Protein kinase, cGMP-dependent, regulatory, type I
            MIM: 190181  Transforming growth factor, beta receptor I (activin A
                         receptor type
            MIM: 601284  Activin A receptor, type II-like kinase 1
            MIM: 601299  Bone morphogenetic protein receptor, type IA
            MIM: 601639  Protein kinase, cAMP-dependent, catalytic, alpha
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS00888  [LIVM]-[VIC]-x(2)-G-[DENQTA]-x-[GAC]-x(2)-[LIVMFY](4)-
                         x(2)-G
            PS: PS00889  [LIVMF]-G-E-x-[GAS]-[LIVM]-x(5,11)-R-[STAQ]-A-x-
                         [LIVMA]-x-[STACV]
            PS: PS01101  C-P-x-[LIVMYA]-x-C-x(5)-[LI]-P-[LIVMC]-G-x(9)-V-[KR]-
                         x(2)-C-P-x-C
            PS: PS50003  PH domain profile
            PS: PS50004  C2-domain profile
            PS: PS50011  Protein kinase domain profile
            PS: PS50017  Death domain profile
            PS: PS50042  cAMP/cGMP binding motif
STRUCTURES  PDB: 1FVV  1FVT  1FOT  1FMO  1F0Q  1E1X  1G3N  1DS5  1DDM  1DAY  
                 2CPK  1CTP  1HCK  1E1V  1HCL  1BX6  1BPK  1BKX  1BDY  1B6C  
                 1B39  1B38  1ATP  1AQ1  1APM  1APK  1YDT  1IA9  1YDR  1IAH  
                 1IAJ  1IAS  1JBP  1JLU  1QF8  1R2A  1RGS  1STC  1YDS  1TBI  
                 1CDK  1CMK  2APK  1CKP  2BPK  1A6O  1DAW  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.37
            ExPASy - ENZYME nomenclature database: 2.7.1.37
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.37
            BRENDA, the Enzyme Database: 2.7.1.37
            SCOP (Structural Classification of Proteins): 2.7.1.37
///
ENTRY       EC 2.7.1.38
NAME        Phosphorylase kinase
            Dephosphophosphorylase kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:phosphorylase-b phosphotransferase
REACTION    4 ATP + 2 Phosphorylase b = 4 ADP + Phosphorylase a
SUBSTRATE   ATP
            Phosphorylase b
PRODUCT     ADP
            Phosphorylase a
COMMENT     See comment on EC 2.7.1.37.
GENES       DME: CG1830(PhKgamma) CG7766
            MMU: 97555(Pgk1) 97576(Phka1) 97577(Phka2)
            HSA: 5255(PHKA1) 5256(PHKA2) 5257(PHKB) 5260(PHKG1) 5261(PHKG2)
                 801(CALM1)
DISEASE     MIM: 172471  Phosphorylase kinase, gamma 2 (testis/liver)
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 1PHK  1QL6  2PHK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.38
            ExPASy - ENZYME nomenclature database: 2.7.1.38
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.38
            BRENDA, the Enzyme Database: 2.7.1.38
            SCOP (Structural Classification of Proteins): 2.7.1.38
///
ENTRY       EC 2.7.1.39
NAME        Homoserine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L-homoserine O-phosphotransferase
REACTION    ATP + L-Homoserine = ADP + O-Phospho-L-homoserine
SUBSTRATE   ATP
            L-Homoserine
PRODUCT     ADP
            O-Phospho-L-homoserine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b0003(thrB)
            ECE: Z0003(thrB)
            ECS: ECs0003
            YPE: YPO0460(thrB)
            HIN: HI0088(thrB)
            PMU: PM0114(thrB)
            XFA: XF2224
            VCH: VC2363
            PAE: PA5495(thrB)
            BUC: BU193(thrB)
            NMA: NMA0411(thrB)
            HPY: HP1050(thrB)
            HPJ: jhp0375
            CJE: Cj0134(thrB)
            MLO: mlr7503
            SME: SMc00017(thrB)
            CCR: CC3364
            BSU: BG10462(thrB)
            BHA: BH3420(thrB)
            SAU: SA1166(thrB)
            SAV: SAV1315(thrB)
            LLA: L0091(thrB)
            SPN: SP1360
            SPR: spr1218(thrB)
            CAC: CAC1235(thrB)
            MTU: Rv1296(thrB)
            MTC: MT1335
            MLE: ML1131(thrB)
            SYN: sll1760(thrB)
            DRA: DR2390
            AAE: aq_1309(thrB)
            TMA: TM0545
            MJA: MJ1104(thrB)
            HAL: VNG1797G(thrB)
            TAC: Ta0530
            TVO: TVG1060320
            PHO: PH1087
            PAB: PAB1676
            APE: APE2067
            SSO: SSO2367(thrB)
            STO: ST0505
            SCE: YHR025W(THR1)
            SPO: SPBC4C3.03(spbc4c3.03)
MOTIF       PS: PS00627  [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-L-[GS]-S-S-[GSA]-[GSTAC]
STRUCTURES  PDB: 1FWK  1H73  1H72  1FWL  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.39
            ExPASy - ENZYME nomenclature database: 2.7.1.39
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.39
            BRENDA, the Enzyme Database: 2.7.1.39
            SCOP (Structural Classification of Proteins): 2.7.1.39
///
ENTRY       EC 2.7.1.40
NAME        Pyruvate kinase
            Phosphoenolpyruvate kinase
            Phosphoenol transphosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pyruvate O2-phosphotransferase
REACTION    ATP + Pyruvate = ADP + Phosphoenolpyruvate;
            UTP + Pyruvate = UDP + Phosphoenolpyruvate;
            GTP + Pyruvate = GDP + Phosphoenolpyruvate;
            CTP + Pyruvate = CDP + Phosphoenolpyruvate;
            ITP + Pyruvate = IDP + Phosphoenolpyruvate;
            dATP + Pyruvate = dADP + Phosphoenolpyruvate
SUBSTRATE   ATP
            UTP
            GTP
            CTP
            ITP
            dATP
            Pyruvate
            Hydroxylamine
            Fluoride
PRODUCT     ADP
            UDP
            GDP
            CDP
            IDP
            dADP
            Phosphoenolpyruvate
            O-Phosphorylhydroxylamine
COFACTOR    CO2
COMMENT     UTP, GTP, CTP, ITP and dATP can also act as donors. Also
            phosphorylates hydroxylamine and fluoride in the presence of CO2.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00230  Purine metabolism
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b1676(pykF) b1854(pykA)
            ECE: Z2704(pykF) Z2906(pykA)
            ECS: ECs2383 ECs2564
            YPE: YPO2064(pykA) YPO2393(pykF)
            HIN: HI1573(pykA)
            PMU: PM0653(pykA)
            XFA: XF0824
            VCH: VC0485 VC2008 VCA0708
            PAE: PA1498(pykF) PA4329(pykA)
            BUC: BU319(pykA)
            NME: NMB0089
            NMA: NMA0177(pykA)
            CJE: Cj0392c(pyk)
            MLO: mll3819
            SME: SMc04005(pykA)
            CCR: CC2051
            BSU: BG12661(pykA)
            BHA: BH3163(pykA)
            SAU: SA1520(pykA)
            SAV: SAV1683(pykA)
            LLA: L0003(pyk)
            SPY: SPy1282(pyk)
            SPN: SP0897
            SPR: spr0797(pykF)
            CAC: CAC0518(pykA) CAC1036(pykA)
            MGE: MG216(pyk)
            MPN: H10_orf508(pyk)
            MPU: MYPU_2400(pyk)
            UUR: UU186(pyk)
            MTU: Rv1617(pykA)
            MTC: MT1653
            MLE: ML1277(pykA)
            CTR: CT332
            CMU: TC0609
            CPN: CPn0097
            CPA: CP0677
            CPJ: pyk
            BBU: BB0348(pyk)
            SYN: sll0587(pyk1) sll1275(pykF)
            DRA: DR2635
            TMA: TM0208
            MJA: MJ0108
            HAL: VNG0324G(pykA)
            TAC: Ta0896
            TVO: TVG1076108
            PHO: PH0570
            PAB: PAB1441
            APE: APE0489
            SSO: SSO0981(pyK)
            SCE: YAL038W(CDC19) YOR347C(PYK2)
            SPO: PYK1(pyk1)
            ATH: At4g26390(M3E9.180)
            CEL: F25H5.3a F25H5.3b ZK593.1
            DME: CG7070(PyK)
            MMU: 97591(Pk3) 97604(Pklr)
            HSA: 5313(PKLR) 5315(PKM2)
DISEASE     MIM: 188555  Thyroid hormone-binding protein, cytosolic (p58)
            MIM: 266200  Pyruvate kinase, liver and RBC type
MOTIF       PS: PS00110  [LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-
                         [DEQHS]-[GSTA]-[LIVM]
STRUCTURES  PDB: 1PKL  1F3W  1PYK  1E0U  1E0T  1AQF  1A5U  1A49  1A3X  1A3W  
                 1F3X  1PKM  1PKN  1PKY  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.40
            ExPASy - ENZYME nomenclature database: 2.7.1.40
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.40
            BRENDA, the Enzyme Database: 2.7.1.40
            SCOP (Structural Classification of Proteins): 2.7.1.40
///
ENTRY       EC 2.7.1.41
NAME        Glucose-1-phosphate phosphodismutase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     D-Glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase
REACTION    2 D-Glucose 1-phosphate = D-Glucose + D-Glucose 1,6-bisphosphate
SUBSTRATE   D-Glucose 1-phosphate
PRODUCT     D-Glucose
            D-Glucose 1,6-bisphosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.41
            ExPASy - ENZYME nomenclature database: 2.7.1.41
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.41
            BRENDA, the Enzyme Database: 2.7.1.41
///
ENTRY       EC 2.7.1.42
NAME        Riboflavin phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     D-Glucose-1-phosphate:riboflavin 5'-phosphotransferase
REACTION    D-Glucose 1-phosphate + Riboflavin = D-Glucose + FMN
SUBSTRATE   D-Glucose 1-phosphate
            Riboflavin
PRODUCT     D-Glucose
            FMN
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.42
            ExPASy - ENZYME nomenclature database: 2.7.1.42
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.42
            BRENDA, the Enzyme Database: 2.7.1.42
///
ENTRY       EC 2.7.1.43
NAME        Glucuronokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-glucuronate 1-phosphotransferase
REACTION    ATP + D-Glucuronate = ADP + 1-Phospho-alpha-D-glucuronate
SUBSTRATE   ATP
            D-Glucuronate
PRODUCT     ADP
            1-Phospho-alpha-D-glucuronate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.43
            ExPASy - ENZYME nomenclature database: 2.7.1.43
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.43
            BRENDA, the Enzyme Database: 2.7.1.43
///
ENTRY       EC 2.7.1.44
NAME        Galacturonokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-galacturonate 1-phosphotransferase
REACTION    ATP + D-Galacturonate = ADP + 1-Phospho-alpha-D-galacturonate
SUBSTRATE   ATP
            D-Galacturonate
PRODUCT     ADP
            1-Phospho-alpha-D-galacturonate
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.44
            ExPASy - ENZYME nomenclature database: 2.7.1.44
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.44
            BRENDA, the Enzyme Database: 2.7.1.44
///
ENTRY       EC 2.7.1.45
NAME        2-Dehydro-3-deoxygluconokinase
            2-Keto-3-deoxygluconokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase
REACTION    ATP + 2-Dehydro-3-deoxy-D-gluconate = ADP +
            6-Phospho-2-dehydro-3-deoxy-D-gluconate
SUBSTRATE   ATP
            2-Dehydro-3-deoxy-D-gluconate
PRODUCT     ADP
            6-Phospho-2-dehydro-3-deoxy-D-gluconate
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b3526(kdgK)
            ECE: Z4940(kdgK)
            ECS: ECs4406
            YPE: YPO3990(kdgK)
            HIN: HI0049(kdgK)
            PAE: PA2261
            MLO: mlr1166
            SME: SMc01531(kdgK)
            CCR: CC1057
            BSU: BG11397(kdgK)
            BHA: BH3724(kdgK)
            LLA: L0021(kdgK)
            SPN: SP0318
            SPR: spr0288(kdgK)
            CAC: CAC0395(kdgK) CAC2684
            TMA: TM0067
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.45
            ExPASy - ENZYME nomenclature database: 2.7.1.45
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.45
            BRENDA, the Enzyme Database: 2.7.1.45
///
ENTRY       EC 2.7.1.46
NAME        L-Arabinokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L-arabinose 1-phosphotransferase
REACTION    ATP + L-Arabinose = ADP + beta-L-Arabinose 1-phosphate
SUBSTRATE   ATP
            L-Arabinose
PRODUCT     ADP
            beta-L-Arabinose 1-phosphate
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.46
            ExPASy - ENZYME nomenclature database: 2.7.1.46
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.46
            BRENDA, the Enzyme Database: 2.7.1.46
///
ENTRY       EC 2.7.1.47
NAME        D-Ribulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-ribulose 5-phosphotransferase
REACTION    ATP + D-Ribulose = ADP + D-Ribulose 5-phosphate
SUBSTRATE   ATP
            D-Ribulose
PRODUCT     ADP
            D-Ribulose 5-phosphate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.47
            ExPASy - ENZYME nomenclature database: 2.7.1.47
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.47
            BRENDA, the Enzyme Database: 2.7.1.47
///
ENTRY       EC 2.7.1.48
NAME        Uridine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:uridine 5'-phosphotransferase
REACTION    ATP + Uridine = ADP + UMP
SUBSTRATE   ATP
            Uridine
            Cytidine
            GTP
            ITP
PRODUCT     ADP
            UMP
            CMP
            GDP
            IDP
COMMENT     Cytidine can act as acceptor; GTP and ITP can act as donors.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2066(udk)
            ECE: Z3234(udk)
            ECS: ECs2873
            YPE: YPO1524(udk)
            HIN: HI0132(udk)
            PMU: PM0952(udk)
            VCH: VC1038
            BSU: BG12696(udk)
            BHA: BH1275(udk)
            SAU: SA1439(udk)
            SAV: SAV1599(udk)
            LLA: L108994(udk)
            SPY: SPy1368(udk)
            SPN: SP1208
            SPR: spr1090(udK)
            CAC: CAC0672
            MGE: MG382(udk)
            MPN: H03_orf213(udk)
            UUR: UU332(udk)
            CPN: CPn0735
            CPA: CP0011
            CPJ: CPj0735
            BBU: BB0015(udk)
            TPA: TP0667
            DRA: DR0159
            TMA: TM0751
            HAL: VNG1219G(urk)
            SCE: YNR012W(URK1)
            CEL: B0001.4 F19B6.1a
            HSA: 7371(UMPK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.48
            ExPASy - ENZYME nomenclature database: 2.7.1.48
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.48
            BRENDA, the Enzyme Database: 2.7.1.48
///
ENTRY       EC 2.7.1.49
NAME        Hydroxymethylpyrimidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine
            $ 5-phosphotransferase
REACTION    ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine = ADP +
            4-Amino-5-phosphomethyl-2-methylpyrimidine
SUBSTRATE   ATP
            4-Amino-5-hydroxymethyl-2-methylpyrimidine
            CTP
            UTP
            GTP
PRODUCT     ADP
            4-Amino-5-phosphomethyl-2-methylpyrimidine
            CDP
            UDP
            GDP
COMMENT     CTP, UTP and GTP can act as donors.
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.49
            ExPASy - ENZYME nomenclature database: 2.7.1.49
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.49
            BRENDA, the Enzyme Database: 2.7.1.49
///
ENTRY       EC 2.7.1.50
NAME        Hydroxyethylthiazole kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase
REACTION    ATP + 4-Methyl-5-(2-hydroxyethyl)-thiazole = ADP +
            4-Methyl-5-(2-phosphoethyl)-thiazole
SUBSTRATE   ATP
            4-Methyl-5-(2-hydroxyethyl)-thiazole
PRODUCT     ADP
            4-Methyl-5-(2-phosphoethyl)-thiazole
PATHWAY     PATH: MAP00730  Thiamine metabolism
GENES       ECO: b2104(thiM)
            ECE: Z3268(thiM)
            ECS: ECs2907
            HIN: HI0415(thim)
            PMU: PM1262(thiM)
            HPY: HP0845
            HPJ: jhp0783
            BSU: BG10571(thiK)
            BHA: BH3349(thiK)
            SAU: SA1895(thiM)
            SAV: SAV2077(thiM)
            LLA: L94809(thiM)
            SPN: SP0717 SP0724
            SPR: spr0629(thiM) spr0636(thiM)
            CAC: CAC3096(thiK)
            AFU: AF2075(thiM)
            PHO: PH1157
            PAB: PAB2432(thiM)
            SCE: YPL214C(THI6)
            SPO: THI4(thi4)
STRUCTURES  PDB: 1C3Q  1EKK  1EKQ  1ESJ  1ESQ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.50
            ExPASy - ENZYME nomenclature database: 2.7.1.50
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.50
            BRENDA, the Enzyme Database: 2.7.1.50
            SCOP (Structural Classification of Proteins): 2.7.1.50
///
ENTRY       EC 2.7.1.51
NAME        L-Fuculokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L-fuculose 1-phosphotransferase
REACTION    ATP + L-Fuculose = ADP + L-Fuculose 1-phosphate
SUBSTRATE   ATP
            L-Fuculose
PRODUCT     ADP
            L-Fuculose 1-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2803(fucK)
            ECE: Z4120(fucK)
            ECS: ECs3663
            HIN: HI0613(fucK)
            SPN: SP2167
MOTIF       PS: PS00445  [GSA]-x-[LIVMFYW]-x-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                         x(2)-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
            PS: PS00933  [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-x-W-[LIVMF]-x-
                         [DENQTKR]-[ENQH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.51
            ExPASy - ENZYME nomenclature database: 2.7.1.51
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.51
            BRENDA, the Enzyme Database: 2.7.1.51
///
ENTRY       EC 2.7.1.52
NAME        Fucokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:6-deoxy-L-galactose 1-phosphotransferase
REACTION    ATP + 6-Deoxy-L-galactose = ADP + 6-Deoxy-L-galactose 1-phosphate
SUBSTRATE   ATP
            6-Deoxy-L-galactose
PRODUCT     ADP
            6-Deoxy-L-galactose 1-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.52
            ExPASy - ENZYME nomenclature database: 2.7.1.52
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.52
            BRENDA, the Enzyme Database: 2.7.1.52
///
ENTRY       EC 2.7.1.53
NAME        L-Xylulokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:L-xylulose 5-phosphotransferase
REACTION    ATP + L-Xylulose = ADP + L-Xylulose 5-phosphate
SUBSTRATE   ATP
            L-Xylulose
PRODUCT     ADP
            L-Xylulose 5-phosphate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b3580(lyx)
            YPE: YPO3334(sgbK)
            HIN: HI1027(lyx)
            PMU: PM1247(lyx)
            SME: SMb20497(lyx)
MOTIF       PS: PS00445  [GSA]-x-[LIVMFYW]-x-G-[LIVM]-x(7,8)-[HDENQ]-[LIVMF]-
                         x(2)-[AS]-[STALIVM]-[LIVMFY]-[DEQ]
            PS: PS00933  [MFYGS]-x-[PST]-x(2)-K-[LIVMFYW]-x-W-[LIVMF]-x-
                         [DENQTKR]-[ENQH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.53
            ExPASy - ENZYME nomenclature database: 2.7.1.53
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.53
            BRENDA, the Enzyme Database: 2.7.1.53
///
ENTRY       EC 2.7.1.54
NAME        D-Arabinokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-arabinose 5-phosphotransferase
REACTION    ATP + D-Arabinose = ADP + D-Arabinose 5-phosphate
SUBSTRATE   ATP
            D-Arabinose
PRODUCT     ADP
            D-Arabinose 5-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.54
            ExPASy - ENZYME nomenclature database: 2.7.1.54
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.54
            BRENDA, the Enzyme Database: 2.7.1.54
///
ENTRY       EC 2.7.1.55
NAME        Allose kinase
            Allokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-allose 6-phosphotransferase
REACTION    ATP + D-Allose = ADP + D-Allose 6-phosphate
SUBSTRATE   ATP
            D-Allose
PRODUCT     ADP
            D-Allose 6-phosphate
MOTIF       PS: PS01125  [LIVM]-x(2)-G-[LIVMFCT]-G-x-[GA]-[LIVMFA]-x(8)-G-
                         x(3,5)-[GATP]-x(2)-G-[RKH]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.55
            ExPASy - ENZYME nomenclature database: 2.7.1.55
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.55
            BRENDA, the Enzyme Database: 2.7.1.55
///
ENTRY       EC 2.7.1.56
NAME        1-Phosphofructokinase
            Fructose-1-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose-1-phosphate 6-phosphotransferase
REACTION    ATP + D-Fructose 1-phosphate = ADP + D-Fructose 1,6-bisphosphate
SUBSTRATE   ATP
            D-Fructose 1-phosphate
            ITP
            GTP
            UTP
PRODUCT     ADP
            D-Fructose 1,6-bisphosphate
            IDP
            GDP
            UDP
COMMENT     ITP, GTP or UTP can replace ATP.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
GENES       ECO: b2168(fruK)
            ECE: Z3426(fruK)
            ECS: ECs3060
            YPE: YPO1299(fruK)
            HIN: HI0447(fruK)
            PMU: PM1796(fruK)
            VCH: VCA0517
            PAE: PA3561(fruK)
            BSU: BG12588(fruB)
            BHA: BH0827(fruB)
            SAU: SA0654(fruB)
            SAV: SAV0686
            LLA: L0032(lacC)
            SPY: SPy0854(fruB)
            SPN: SP0876
            SPR: spr0779(fruB)
            CAC: CAC0232(fruB)
            MGE: MG063(fruK)
            MPN: R02_orf300(fruK)
            BBU: BB0630(fruK)
            DRA: DRB0074
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.56
            ExPASy - ENZYME nomenclature database: 2.7.1.56
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.56
            BRENDA, the Enzyme Database: 2.7.1.56
///
ENTRY       EC 2.7.1.57
NAME        Deleted entry
            Mannitol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.57
            ExPASy - ENZYME nomenclature database: 2.7.1.57
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.57
///
ENTRY       EC 2.7.1.58
NAME        2-Dehydro-3-deoxygalactonokinase
            2-Keto-3-deoxy-galactonokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:2-dehydro-3-deoxy-galactonokinase
REACTION    ATP + 2-Dehydro-3-deoxy-D-galactonate = ADP +
            2-Dehydro-3-deoxy-D-galactonate 6-phosphate
SUBSTRATE   ATP
            2-Dehydro-3-deoxy-D-galactonate
PRODUCT     ADP
            2-Dehydro-3-deoxy-D-galactonate 6-phosphate
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       ECO: b3693(dgoK)
            SME: SMc00881(dgoK1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.58
            ExPASy - ENZYME nomenclature database: 2.7.1.58
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.58
            BRENDA, the Enzyme Database: 2.7.1.58
///
ENTRY       EC 2.7.1.59
NAME        N-Acetylglucosamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:N-acetyl-D-glucosamine 6-phosphotransferase
REACTION    ATP + N-Acetyl-D-glucosamine = ADP +
            N-Acetyl-D-glucosamine 6-phosphate
SUBSTRATE   ATP
            N-Acetyl-D-glucosamine
PRODUCT     ADP
            N-Acetyl-D-glucosamine 6-phosphate
COMMENT     The bacterial enzyme also acts on D-glucose.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.59
            ExPASy - ENZYME nomenclature database: 2.7.1.59
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.59
            BRENDA, the Enzyme Database: 2.7.1.59
///
ENTRY       EC 2.7.1.60
NAME        N-Acylmannosamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:N-acyl-D-mannosamine 6-phosphotransferase
REACTION    ATP + N-Acyl-D-mannosamine = ADP +
            N-Acyl-D-mannosamine 6-phosphate
SUBSTRATE   ATP
            N-Acyl-D-mannosamine
            N-Acetyl-D-mannosamine
            N-Glycolyl-D-mannosamine
PRODUCT     ADP
            N-Acyl-D-mannosamine 6-phosphate
            N-Acetyl-D-mannosamine 6-phosphate
            N-Glycolyl-D-mannosamine 6-phosphate
COMMENT     Acts on the acetyl and glycolyl derivatives.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.60
            ExPASy - ENZYME nomenclature database: 2.7.1.60
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.60
            BRENDA, the Enzyme Database: 2.7.1.60
///
ENTRY       EC 2.7.1.61
NAME        Acyl-phosphate--hexose phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Acyl-phosphate:D-hexose phosphotransferase
REACTION    Acyl phosphate + D-Hexose = an Acid + D-Hexose phosphate
SUBSTRATE   Acyl phosphate
            D-Hexose
            D-Glucose
            D-Mannose
PRODUCT     Acid
            D-Hexose phosphate
            D-Glucose 6-phosphate
            D-Mannose 1-phosphate
            D-Mannose 6-phosphate
COMMENT     Phosphorylates D-glucose and D-mannose on O-6, and D-fructose on
            O-1 or O-6.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.61
            ExPASy - ENZYME nomenclature database: 2.7.1.61
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.61
            BRENDA, the Enzyme Database: 2.7.1.61
///
ENTRY       EC 2.7.1.62
NAME        Phosphoramidate--hexose phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Phosphoramidate:hexose 1-phosphotransferase
REACTION    Phosphoramidate + Hexose = NH3 + Hexose 1-phosphate
SUBSTRATE   Phosphoramidate
            Hexose
PRODUCT     NH3
            Hexose 1-phosphate
COMMENT     May be identical with EC 3.1.3.9.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.62
            ExPASy - ENZYME nomenclature database: 2.7.1.62
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.62
            BRENDA, the Enzyme Database: 2.7.1.62
///
ENTRY       EC 2.7.1.63
NAME        Polyphosphate--glucose phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Polyphosphate:D-glucose 6-phosphotransferase
REACTION    (Phosphate)n + D-Glucose = (Phosphate)n-1 + D-Glucose 6-phosphate
SUBSTRATE   (Phosphate)n
            D-Glucose
            D-Glucosamine
PRODUCT     (Phosphate)n-1
            D-Glucose 6-phosphate
            D-Glucosamine 6-phosphate
COFACTOR    Neutral salt
COMMENT     Requires a neutral salt, e.g. KCl, for maximum activity. Also
            acts on glucosamine.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       MTU: Rv2702(ppgK)
            MTC: MT2776
            MLE: ML1023(ppgK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.63
            ExPASy - ENZYME nomenclature database: 2.7.1.63
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.63
            BRENDA, the Enzyme Database: 2.7.1.63
///
ENTRY       EC 2.7.1.64
NAME        myo-Inositol 1-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:myo-inositol 1-phosphotransferase
REACTION    ATP + myo-Inositol = ADP + 1L-myo-Inositol 1-phosphate
SUBSTRATE   ATP
            myo-Inositol
PRODUCT     ADP
            1L-myo-Inositol 1-phosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.64
            ExPASy - ENZYME nomenclature database: 2.7.1.64
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.64
            BRENDA, the Enzyme Database: 2.7.1.64
///
ENTRY       EC 2.7.1.65
NAME        scyllo-Inosamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase
REACTION    ATP + 1-Amino-1-deoxy-scyllo-inositol = ADP +
            1-Amino-1-deoxy-scyllo-inositol 4-phosphate
SUBSTRATE   ATP
            1-Amino-1-deoxy-scyllo-inositol
            Streptamine
            2-Deoxystreptamine
            1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol
PRODUCT     ADP
            1-Amino-1-deoxy-scyllo-inositol 4-phosphate
            Streptamine 4-phosphate
            2-Deoxystreptamine 4-phosphate
            1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 4-phosphate
COMMENT     Also acts on streptamine, 2-deoxystreptamine and
            1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol.
PATHWAY     PATH: MAP00521  Streptomycin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.65
            ExPASy - ENZYME nomenclature database: 2.7.1.65
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.65
            BRENDA, the Enzyme Database: 2.7.1.65
///
ENTRY       EC 2.7.1.66
NAME        Undecaprenol kinase
            Isoprenoid-alcohol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:undecaprenol phosphotransferase
REACTION    ATP + Undecaprenol = ADP + Undecaprenyl phosphate
SUBSTRATE   ATP
            Undecaprenol
PRODUCT     ADP
            Undecaprenyl phosphate
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b3057(bacA)
            ECE: Z4410(bacA)
            ECS: ECs3940
            YPE: YPO0649(bacA)
            XFA: XF1841
            VCH: VC0526
            PAE: PA1959(bacA)
            BUC: BU062(bacA)
            NME: NMB0408
            NMA: NMA2077
            CJE: Cj0205(bacA)
            MLO: mll4634 mlr0116
            SME: SMc00408
            CCR: CC3605
            BSU: BG13951(yubB)
            BHA: BH0464 BH1521
            SAU: SA0638(bacA)
            SAV: SAV0670(bacA)
            LLA: L58643(bacA)
            SPY: SPy0280(bacA)
            SPN: SP0457
            SPR: spr0413(bacA)
            CAC: CAC0501(bacA) CAC0963(bacA)
            MTU: Rv2136c
            MTC: MT2194
            MLE: ML1297
            BBU: BB0258(bacA)
            SYN: sll0210
            DRA: DR0454
            AAE: aq_2195(bacA)
            TMA: TM0893
            MTH: MTH1428 MTH1429
            SSO: SSO1860
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.66
            ExPASy - ENZYME nomenclature database: 2.7.1.66
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.66
            BRENDA, the Enzyme Database: 2.7.1.66
///
ENTRY       EC 2.7.1.67
NAME        1-Phosphatidylinositol 4-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase
REACTION    ATP + 1-Phosphatidyl-1D-myo-inositol = ADP +
            1-Phosphatidyl-1D-myo-inositol 4-phosphate
SUBSTRATE   ATP
            1-Phosphatidyl-1D-myo-inositol
PRODUCT     ADP
            1-Phosphatidyl-1D-myo-inositol 4-phosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       SCE: YLR305C(STT4) YNL267W(PIK1)
            SPO: SPAC22E12.16C(spac22e12.16c)
            DME: CG10260
            HSA: 5297(PIK4CA)
MOTIF       PS: PS00915  [LIVMFAC]-K-x(1,3)-[DEA]-[DE]-[LIVMC]-R-Q-[DE]-x(4)-Q
            PS: PS00916  [GS]-x-[AV]-x(3)-[LIVM]-x(2)-[FYH]-[LIVM](2)-x-[LIVMF]-
                         x-D-R-H-x(2)-N
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.67
            ExPASy - ENZYME nomenclature database: 2.7.1.67
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.67
            BRENDA, the Enzyme Database: 2.7.1.67
///
ENTRY       EC 2.7.1.68
NAME        1-Phosphatidylinositol-4-phosphate kinase
            Diphosphoinositide kinase
            PIP kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate
            $ 5-phosphotransferase
REACTION    ATP + 1-Phosphatidyl-1D-myo-inositol 4-phosphate = ADP +
            1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
SUBSTRATE   ATP
            1-Phosphatidyl-1D-myo-inositol 4-phosphate
PRODUCT     ADP
            1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       SCE: YDR208W(MSS4) YFR019W(FAB1)
            SPO: SPAC19G12.14(spac19g12.14)
            DME: CG6355(EG:52C10.5) CG9985(sktl)
            HSA: 5305(PIP5K2A)
STRUCTURES  PDB: 1BO1  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.68
            ExPASy - ENZYME nomenclature database: 2.7.1.68
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.68
            BRENDA, the Enzyme Database: 2.7.1.68
            SCOP (Structural Classification of Proteins): 2.7.1.68
///
ENTRY       EC 2.7.1.69
NAME        Protein-N(pai)-phosphohistidine--sugar phosphotransferase
            Enzyme II of the phosphotransferase system (cf. EC 2.7.3.9)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Protein-N(pai)-phosphohistidine:sugar N(pai)-phosphotransferase
REACTION    Protein N(pai)-phosphohistidine + Sugar = Protein histidine +
            Sugar phosphate
SUBSTRATE   Protein N(pai)-phosphohistidine
            Sugar
            Aldohexose
            Glycoside of aldohexose
            Alditol
            Fructose
            Sorbose
            Glycerone
            1,3-Dihydroxypropan-2-one
            Disaccharide
PRODUCT     Protein histidine
            Sugar phosphate
            Aldohexose 6-phosphate
            Alditol 6-phosphate
            Fructose 1-phosphate
            Sorbose 1-phosphate
COMMENT     Comprises a group of related enzymes. The protein substrate is a
            phsophocarrier protein of low molecular mass (9.5 kDa). A
            phosphoenzyme intermediate is formed. The enzyme translocates
            the sugar it phosphorylates into bacteria. Aldohexoses and their
            glycosides and alditols are phosphorylated on O-6; fructose and
            sorbose on O-1. Glycerone and disaccharides are also substrates.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b0129(yadI) b0679(nagE) b0731(hrsA) b1101(ptsG) b1621(malX)
                 b1736(celC) b1738(celA) b1817(manX) b2093(gatB) b2094(gatA)
                 b2167(fruA) b2169(fruB) b2387 b2417(crr) b2429 b2702(srlA_1)
                 b2703(srlA) b2704(srlB) b2715(ascF) b2933(cmtA) b2934(cmtB)
                 b3133(agaV) b3138(agaB) b3204(ptsN) b3599(mtlA) b3682(glvB)
                 b3722(bglF) b3899(frvB) b3900(frvA) b3950(frwB) b3953(frwD)
                 b4194(sgaB) b4195(sgaA) b4240(treB) b4302(sgcA)
            ECE: Z0140(yadI) Z0826(nagE) Z1740(ptsG) Z2626(malX) Z2766(celC)
                 Z2768(celA) Z2860(manX) Z3256(gatB) Z3257(gatA) Z3425(fruA)
                 Z3427(fruB) Z3653 Z3683(crr) Z3694 Z4005(srlA_1) Z4006(srlA_2)
                 Z4007(srlE_1) Z4009(srlE_2) Z4011(srlB) Z4023(ascF)
                 Z4277(cmtA) Z4278(cmtB) Z4485(agaV) Z4488 Z4492(agaB)
                 Z4567(ptsN) Z4875 Z4876 Z5023(mtlA) Z5178 Z5442(frvB)
                 Z5443(frvA) Z5506(frwB) Z5509(frwD) Z5616 Z5617 Z5803(sgaB)
                 Z5804(ptxA) Z5850(treB)
            ECS: ECs0133 ECs0709 ECs1479 ECs2329 ECs2442 ECs2444 ECs2527
                 ECs2896 ECs2897 ECs3059 ECs3061 ECs3266 ECs3267 ECs3289
                 ECs3300 ECs3559 ECs3560 ECs3571 ECs3808 ECs3809 ECs4011
                 ECs4014 ECs4018 ECs4083 ECs4350 ECs4475 ECs4623 ECs4825
                 ECs4826 ECs4878 ECs4879 ECs4882 ECs4942 ECs4999 ECs5000
                 ECs5001 ECs5002 ECs5170 ECs5171 ECs5217
            YPE: YPO0402 YPO0403 YPO0404 YPO1298(fruB) YPO1300(fruA)
                 YPO1608(ptsG) YPO1758(manX) YPO2628(nagE) YPO2678(celA)
                 YPO2680(celC) YPO2995(crr) YPO3585(ptsN) YPO3697(treB)
                 YPO4068(mtlA)
            HIN: HI0446(fruA) HI0448(fruB) HI1147(ptsN) HI1711(crr)
            PMU: PM0170(ptsN) PM0764 PM0765 PM0834 PM0876 PM0896(crr)
                 PM1061(ptmA) PM1575 PM1752(ptsG) PM1795(fruA) PM1797(fruB)
                 PM1846(ptsB) PM1969 PM1970 PM1971
            VCH: VC0207 VC0518 VC0910 VC0964 VC0995 VC1281 VC1283 VC1820
                 VC1821 VC1822 VC1823 VC1824 VC1826 VC2013 VC2531 VCA0245
                 VCA0246 VCA0516 VCA0518 VCA0653 VCA1045
            PAE: PA3560(fruA) PA3562 PA3760 PA3761 PA4464(ptsN)
            BUC: BU063(crr) BU356(ptsG) BU572(mtlA)
            NME: NMB0736 NMB2046
            NMA: NMA0390 NMA0946
            MLO: mll3194 mll3610 mll3613 mll3614 mll5091
            SME: SMc01141(ptsN) SMc02753
            CCR: CC0240 CC0448 CC0449 CC0488 CC0537 CC0538 CC3596
            BSU: BG10198(ptsG) BG10316(levD) BG10317(levE) BG10560(sacX)
                 BG10595(sacP) BG10934(bglP) BG11009(treP) BG11014(gamP)
                 BG11215(mtlA) BG11347(licB) BG11349(licA) BG11450(ypqE)
                 BG11567(ybbF) BG11848(glvC) BG11938(fruA) BG12190(ydhM)
                 BG12191(ydhN) BG12941(nagP) BG13176(manP) BG14172(yyzE)
            BHA: BH0191(gatB) BH0192(gatA) BH0296 BH0422 BH0595(bglP) BH0673
                 BH0771 BH0772 BH0773 BH0828(fruA) BH0844 BH0909 BH0910 BH1515
                 BH1856(sacP) BH2216 BH3574 BH3852 BH3854 BH3920 BH3921
            SAU: SA0183(glcA) SA0186 SA0233 SA0236 SA0237 SA0255 SA0320
                 SA0432(treP) SA0655(fruA) SA1255 SA1547(ptaA) SA1960(mtlF)
                 SA1962(mtlA) SA1992(lacE) SA1993(lacF) SA2114(glvC)
                 SA2167(scrA) SA2326(ptsG) SA2434
            SAV: SAV0184 SAV0187 SAV0235 SAV0238 SAV0239(gatB) SAV0258 SAV0321
                 SAV0461(treP) SAV0687(fruA) SAV1410 SAV1712(ptaA)
                 SAV2142(mtlF) SAV2144(mtlA) SAV2176(lacE) SAV2177(lacF)
                 SAV2308(glvC) SAV2362(scrA) SAV2521(ptsG) SAV2625
            LLA: L145238(yleD) L146623(ptnC) L146642(yleE) L147466(ptnD)
                 L1762179(ptnAB) L177520(celB) L185031(fruA) L18872(ptcB)
                 L19292(ptcA) L20847(ptcC) L31294(yidB) L32907(mtlF)
                 L37338(yedE) L37906(yedF) L90678(ptbA)
            SPY: SPy0175 SPy0176 SPy0572 SPy0631(agaV) SPy0634(agaF) SPy0855
                 SPy1058 SPy1323 SPy1324 SPy1710 SPy1711 SPy1738(manL)
                 SPy1815(scrA) SPy1917(lacE) SPy1918(lacF) SPy1986 SPy2051
                 SPy2052 SPy2097
            SPN: SP0061 SP0064 SP0248 SP0249 SP0284 SP0305 SP0308 SP0321
                 SP0323 SP0394 SP0396 SP0476 SP0478 SP0577 SP0645 SP0646 SP0758
                 SP0877 SP1185 SP1186 SP1197 SP1198 SP1618 SP1619 SP1684 SP1722
                 SP1884 SP2022 SP2023 SP2024 SP2036 SP2037 SP2163 SP2164
            SPR: spr0060(PTS-EIIB) spr0063(PTS-EII) spr0229(PTS-EIIA)
                 spr0230(PTS-EIIB) spr0261(manL) spr0278(PTS-EII)
                 spr0280(PTS-EII) spr0291(PTS-EII) spr0293(PTS-EII)
                 spr0356(mtlA) spr0358(mtlF) spr0423(PTS-EII) spr0425(PTS-EII)
                 spr0505(PTS-EII) spr0562(PTS-EII) spr0563 spr0668(ptsG)
                 spr0780(fruA) spr1070(lacE) spr1528(PTS-EII) spr1566(scrA)
                 spr1699(treP) spr1835(ptcB) spr1836(ptcA)
            CAC: CAC0154(MtlA) CAC0156(MltF) CAC0233 CAC0234 CAC0383
                 CAC0384(licB) CAC0423 CAC0532 CAC0570 CAC1353 CAC1354 CAC1407
                 CAC1457 CAC1458 CAC2957 CAC2958 CAC2964(lacE) CAC2965(lacF)
                 CAC2995 CAC3425(glvC) CAC3427
            MGE: MG062(fruA) MG069(ptsG)
            MPN: E09_orf143(mtlF) E09_orf379(mtlA) GT9_orf940o(ptsG) MPN495
                 P02_orf159(yjfU) R02_orf694(fruA)
            MPU: MYPU_0170(ptsG) MYPU_1290(fruA) MYPU_1980(sgaT) MYPU_3610
                 MYPU_3640 MYPU_5950(sgaB) MYPU_5960(sgaA) MYPU_7400(licA)
                 MYPU_7510(mtlA) MYPU_7520(mtlA)
            CTR: CT290 CT291
            CMU: TC0563 TC0564
            CPN: CPn0060 CPn0061
            CPA: CP0714 CP0715
            CPJ: ptsN_1 ptsN_2
            BBU: BB0116(malX) BB0408(fruA-1) BB0559(crr) BB0629(fruA-2)
                 BB0645(ptsG) BBB05(celC) BBB06(celA) BBB29(malX)
            TPA: TP0085 TP0755
            DRA: DRB0073
MOTIF       PS: PS00369  G-[LIVM]-H-[STAV]-R-[PAS]-[GSTA]-[STAMVN]
            PS: PS00370  G-[GA]-x-[STN]-x-H-[STA]-[STAV]-[LIVM](2)-[STAV]-[RG]
            PS: PS00371  G-x(2)-[LIVMFA]-[LIVMF](2)-H-[LIVMF]-G-[LIVMF]-x-T-
                         [LIVA]
            PS: PS00372  [DENQ]-x(6)-[LIVMF]-[GA]-x(2)-[LIVM]-A-[LIVM]-P-H-[GAC]
            PS: PS00589  [GSTADE]-[KREQSTIV]-x(4)-[KRDN]-S-[LIVMF](2)-x-[LIVM]-
                         x(2)-[LIVM]-[GADE]
            PS: PS00742  [DEQSK]-x-[LIVMF]-S-[LIVMF]-G-[ST]-N-D-[LIVM]-x-Q-
                         [LIVMFYGT]-[STALIV]-[LIVMFY]-[GAS]-x(2)-R
            PS: PS01035  N-[LIVMFY]-x(5)-C-x-T-R-[LIVMF]-x-[LIVMF]-x-[LIVM]-x-
                         [DQ]
STRUCTURES  PDB: 1A6J  1IIB  1AX3  1PDO  2F3G  1BLE  1GPR  1E2A  1IBA  1F3Z  
                 1GGR  1H9C  2GPR  1E2B  1A3A  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.69
            ExPASy - ENZYME nomenclature database: 2.7.1.69
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.69
            BRENDA, the Enzyme Database: 2.7.1.69
            SCOP (Structural Classification of Proteins): 2.7.1.69
///
ENTRY       EC 2.7.1.70
NAME        Protamine kinase
            Histone kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protamine O-phosphotransferase
REACTION    ATP + Protamine = ADP + O-Phosphoprotamine
SUBSTRATE   ATP
            Protamine
PRODUCT     ADP
            O-Phosphoprotamine
COFACTOR    3',5'-Cyclic AMP
COMMENT     Phosphorylates serine residues in protamines and histones.
            Requires cyclic AMP. See comment on EC 2.7.1.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.70
            ExPASy - ENZYME nomenclature database: 2.7.1.70
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.70
            BRENDA, the Enzyme Database: 2.7.1.70
///
ENTRY       EC 2.7.1.71
NAME        Shikimate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:shikimate 3-phosphotransferase
REACTION    ATP + Shikimate = ADP + Shikimate 3-phosphate
SUBSTRATE   ATP
            Shikimate
PRODUCT     ADP
            Shikimate 3-phosphate
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b0388(aroL) b3390(aroK)
            ECE: Z0484(aroL) Z4743(aroK)
            ECS: ECs0438 ECs4232
            YPE: YPO0151(aroK) YPO3215(aroL)
            HIN: HI0207(aroK)
            PMU: PM1224(aroK)
            XFA: XF1335
            VCH: VC2629
            PAE: PA5039(aroK)
            BUC: BU539(aroK)
            NME: NMB1813
            NMA: NMA0648(aroK)
            HPY: HP0157(aroK)
            HPJ: jhp0145
            CJE: Cj0387(aroK)
            MLO: mll3573
            SME: SMc00695(aroK)
            CCR: CC3008
            BSU: BG10457(aroK)
            BHA: BH0500(aroI)
            SAU: SA1368
            SAV: SAV1527(aroI)
            LLA: L0056(aroK)
            SPY: SPy1351(aroK)
            SPN: SP1370
            SPR: spr1228(aroK)
            CAC: CAC0898(aroK)
            MTU: Rv2539c(aroK)
            MTC: MT2614
            MLE: ML0517(aroK)
            CTR: CT367
            CMU: TC0646
            CPN: CPn1038
            CPA: CP0814
            CPJ: aroL
            SYN: sll1669(aroK)
            DRA: DR0776
            AAE: aq_2177(aroK)
            TMA: TM0348
            MJA: MJ1399 MJ1440
            MTH: MTH805
            AFU: AF0520
            HAL: VNG1245C
            TAC: Ta0283
            TVO: TVG1385893
            PAB: PAB0301(thrB-2)
            APE: APE0572
            SSO: SSO0308
            SCE: YDR127W(ARO1)
MOTIF       PS: PS00104  [LIVF]-x(2)-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-x-R-
                         x-[LIVMFYAT]-x-[GSTAP]
            PS: PS00885  [KR]-x-[KH]-E-[CST]-[DNE]-R-[LIVM]-x-[GSTAV]-[LIVMCT]-
                         x(3)-[LIVMF]-x(2)-[LIVMFCGAN]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-
                         H-[DN]
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMFG]
STRUCTURES  PDB: 1SHK  2SHK  1E6C  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.71
            ExPASy - ENZYME nomenclature database: 2.7.1.71
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.71
            BRENDA, the Enzyme Database: 2.7.1.71
            SCOP (Structural Classification of Proteins): 2.7.1.71
///
ENTRY       EC 2.7.1.72
NAME        Streptomycin 6-kinase
            Streptidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:streptomycin 6-phosphotransferase
REACTION    ATP + Streptomycin = ADP + Streptomycin 6-phosphate
SUBSTRATE   ATP
            Streptomycin
            dATP
            Dihydrostreptomycin
            Streptidine
            2-Deoxystreptidine
PRODUCT     ADP
            Streptomycin 6-phosphate
            dADP
COMMENT     dATP can replace ATP; and dihydrostreptomycin, streptidine
            and 2-deoxystreptidine can act as acceptors (streptomycins
            are a class of antibiotics).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.72
            ExPASy - ENZYME nomenclature database: 2.7.1.72
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.72
            BRENDA, the Enzyme Database: 2.7.1.72
///
ENTRY       EC 2.7.1.73
NAME        Inosine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:inosine 5'-phosphotransferase
REACTION    ATP + Inosine = ADP + IMP
SUBSTRATE   ATP
            Inosine
PRODUCT     ADP
            IMP
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0477(gsk)
            ECE: Z0596(gsk)
            ECS: ECs0530
            YPE: YPO3095(gsk)
            VCH: VC1129
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.73
            ExPASy - ENZYME nomenclature database: 2.7.1.73
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.73
            BRENDA, the Enzyme Database: 2.7.1.73
///
ENTRY       EC 2.7.1.74
NAME        Deoxycitidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     NTP:deoxycitidine 5'-phosphotransferase
REACTION    NTP + Deoxycytidine = NDP + dCMP
SUBSTRATE   NTP
            Deoxycytidine
            Cytosine arabinoside
PRODUCT     NDP
            dCMP
COMMENT     Cytosine arabinoside can act as acceptor; all natural nucleoside
            triphosphates (except dCTP) can act as donors.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       BBU: BB0239(dck)
            HSA: 1633(DCK)
DISEASE     MIM: 125450  Deoxycytidine kinase
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.74
            ExPASy - ENZYME nomenclature database: 2.7.1.74
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.74
            BRENDA, the Enzyme Database: 2.7.1.74
///
ENTRY       EC 2.7.1.75
NAME        Deleted entry
            Thymidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry. Now EC 2.7.1.21.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.75
            ExPASy - ENZYME nomenclature database: 2.7.1.75
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.75
///
ENTRY       EC 2.7.1.76
NAME        Deoxyadenosine kinase
            Purine-deoxyribonucleoside kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:deoxyadenosine 5'-phosphotransferase
REACTION    ATP + Deoxyadenosine = ADP + dAMP
SUBSTRATE   ATP
            Deoxyadenosine
            Deoxyguanosine
PRODUCT     ADP
            dAMP
            dGMP
COMMENT     Deoxyguanosine can also act as acceptor. Possibly identical with
            EC 2.7.1.74.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.76
            ExPASy - ENZYME nomenclature database: 2.7.1.76
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.76
            BRENDA, the Enzyme Database: 2.7.1.76
///
ENTRY       EC 2.7.1.77
NAME        Nucleoside phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Nucleotide:2'-nucleoside 5'-phosphotransferase
REACTION    a Nucleotide + a Deoxynucleoside = a Nucleoside +
            a Deoxynucleoside 5'-phosphate
SUBSTRATE   Nucleotide
            Deoxynucleoside
PRODUCT     Nucleoside
            Deoxynucleoside 5'-phosphate
COMMENT     Phenyl phosphate and nucleoside 3'-phosphates can act as donors,
            although not so well as nucleoside 5'-phosphates.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.77
            ExPASy - ENZYME nomenclature database: 2.7.1.77
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.77
            BRENDA, the Enzyme Database: 2.7.1.77
///
ENTRY       EC 2.7.1.78
NAME        Polynucleotide 5'-hydroxyl-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:5'-dephosphopolynucleotide 5'-phosphotransferase
REACTION    ATP + 5'-Dephospho-DNA = ADP + 5'-Phospho-DNA
SUBSTRATE   ATP
            5'-Dephospho-DNA
            5'-Dephospho-RNA 3'-mononucleotide
PRODUCT     ADP
            5'-Phospho-DNA
            5'-Phospho-RNA 3'-mononucleotide
COMMENT     Also acts on 5'-dephospho-RNA 3'-mononucleotides
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.78
            ExPASy - ENZYME nomenclature database: 2.7.1.78
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.78
            BRENDA, the Enzyme Database: 2.7.1.78
///
ENTRY       EC 2.7.1.79
NAME        Pyrophosphate--glycerol phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Pyrophosphate:glycerol 1-phosphotransferase
REACTION    Pyrophosphate + Glycerol = Orthophosphate + Glycerol 1-phosphate
SUBSTRATE   Pyrophosphate
            Glycerol
PRODUCT     Orthophosphate
            Glycerol 1-phosphate
COMMENT     May be identical with EC 3.1.3.9.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.79
            ExPASy - ENZYME nomenclature database: 2.7.1.79
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.79
            BRENDA, the Enzyme Database: 2.7.1.79
///
ENTRY       EC 2.7.1.80
NAME        Pyrophosphate--serine phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Pyrophosphate:L-serine O-phosphotransferase
REACTION    Pyrophosphate + L-Serine = Orthophosphate + O-Phospho-L-serine
SUBSTRATE   Pyrophosphate
            L-Serine
PRODUCT     Orthophosphate
            O-Phospho-L-serine
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.80
            ExPASy - ENZYME nomenclature database: 2.7.1.80
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.80
            BRENDA, the Enzyme Database: 2.7.1.80
///
ENTRY       EC 2.7.1.81
NAME        Hydroxylysine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     GTP:5-hydroxy-L-lysine O-phosphotransferase
REACTION    GTP + 5-Hydroxy-L-lysine = GDP + 5-Phosphonooxy-L-lysine
SUBSTRATE   GTP
            5-Hydroxy-L-lysine
PRODUCT     GDP
            5-Phosphonooxy-L-lysine
COMMENT     Both the natural 5-hydroxy-L-lysine and its 5-epimer act as
            acceptors.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.81
            ExPASy - ENZYME nomenclature database: 2.7.1.81
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.81
            BRENDA, the Enzyme Database: 2.7.1.81
///
ENTRY       EC 2.7.1.82
NAME        Ethanolamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:ethanolamine O-phosphotransferase
REACTION    ATP + Ethanolamine = ADP + O-Phosphoethanolamine
SUBSTRATE   ATP
            Ethanolamine
PRODUCT     ADP
            O-Phosphoethanolamine
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       DME: CG3525(eas) CG3525_1(eas)
            HSA: 1120(CHKL) 55500(EKI1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.82
            ExPASy - ENZYME nomenclature database: 2.7.1.82
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.82
            BRENDA, the Enzyme Database: 2.7.1.82
///
ENTRY       EC 2.7.1.83
NAME        Pseudouridine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:pseudouridine 5'-phosphotransferase
REACTION    ATP + Pseudouridine = ADP + Pseudouridine 5'-phosphate
SUBSTRATE   ATP
            Pseudouridine
PRODUCT     ADP
            Pseudouridine 5'-phosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.83
            ExPASy - ENZYME nomenclature database: 2.7.1.83
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.83
            BRENDA, the Enzyme Database: 2.7.1.83
///
ENTRY       EC 2.7.1.84
NAME        Alkylglycerone kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:O-alkylglycerone phosphotransferase
REACTION    ATP + O-Alkylglycerone = ADP + O-Alkylglycerone phosphate
SUBSTRATE   ATP
            O-Alkylglycerone
PRODUCT     ADP
            O-Alkylglycerone phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.84
            ExPASy - ENZYME nomenclature database: 2.7.1.84
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.84
            BRENDA, the Enzyme Database: 2.7.1.84
///
ENTRY       EC 2.7.1.85
NAME        beta-Glucoside kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:cellobiose 6-phosphotransferase
REACTION    ATP + Cellobiose = ADP + 6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
SUBSTRATE   ATP
            Cellobiose
            GTP
            CTP
            ITP
            UTP
PRODUCT     ADP
            6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
            GDP
            CDP
            IDP
            UDP
COMMENT     Phosphorylates a number of beta-D-glucosides; GTP, CTP, ITP and
            UTP can also act as donors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.85
            ExPASy - ENZYME nomenclature database: 2.7.1.85
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.85
            BRENDA, the Enzyme Database: 2.7.1.85
///
ENTRY       EC 2.7.1.86
NAME        NADH kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:NADH 2'-phosphotransferase
REACTION    ATP + NADH = ADP + NADPH
SUBSTRATE   ATP
            NADH
            CTP
            ITP
            UTP
            GTP
PRODUCT     ADP
            NADPH
            CDP
            IDP
            UDP
            GDP
EFFECTOR    Acetate
COMMENT     CTP, ITP, UTP and GTP can also act as phosphate donors (in
            decreasing order of activity). The enzyme is specific for NADH.
            Activated by acetate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.86
            ExPASy - ENZYME nomenclature database: 2.7.1.86
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.86
            BRENDA, the Enzyme Database: 2.7.1.86
///
ENTRY       EC 2.7.1.87
NAME        Streptomycin 3''-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:streptomycin 3''-phosphotransferase
REACTION    ATP + Streptomycin = ADP + Streptomycin 3''-phosphate
SUBSTRATE   ATP
            Streptomycin
            Dihydrostreptomycin
            3'-Deoxydihydrostreptomycin
            Dihydrostreptomycin 6-phosphate
            3'-Deoxydihydrostreptomycin 6-phosphate
PRODUCT     ADP
            Streptomycin 3''-phosphate
            Dihydrostreptomycin 3''-phosphate
            3'-Deoxydihydrostreptomycin 3''-phosphate
            Dihydrostreptomycin 6,3''-bis-phosphate
            3'-Deoxydihydrostreptomycin 6,3''-bis-phosphate
COMMENT     Also phosphorylates dihydrostreptomycin, 3'-deoxydihydro-
            streptomycin and their 6-phosphates (streptomycins are a
            class of antibiotics).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.87
            ExPASy - ENZYME nomenclature database: 2.7.1.87
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.87
            BRENDA, the Enzyme Database: 2.7.1.87
///
ENTRY       EC 2.7.1.88
NAME        Dihydrostreptomycin-6-phosphate 3'alpha-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase
REACTION    ATP + Dihydrostreptomycin 6-phosphate = ADP +
            Dihydrostreptomycin 3'alpha,6-bisphosphate
SUBSTRATE   ATP
            Dihydrostreptomycin 6-phosphate
            3'-Deoxydihydrostreptomycin 6-phosphate
PRODUCT     ADP
            Dihydrostreptomycin 3'alpha,6-bisphosphate
            3'-Deoxydihydrostreptomycin 3'alpha,6-bisphosphate
COMMENT     3'-Deoxydihydrostreptomycin 6-phosphate can also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.88
            ExPASy - ENZYME nomenclature database: 2.7.1.88
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.88
            BRENDA, the Enzyme Database: 2.7.1.88
///
ENTRY       EC 2.7.1.89
NAME        Thiamin kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:thiamine phosphotransferase
REACTION    ATP + Thiamine = ADP + Thiamine monophosphate
SUBSTRATE   ATP
            Thiamine
PRODUCT     ADP
            Thiamine monophosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.89
            ExPASy - ENZYME nomenclature database: 2.7.1.89
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.89
            BRENDA, the Enzyme Database: 2.7.1.89
///
ENTRY       EC 2.7.1.90
NAME        Pyrophosphate--fructose-6-phosphate 1-phosphotransferase
            6-Phosphofructokinase (pyrophosphate)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Pyrophosphate:D-fructose-6-phosphate 1-phosphotransferase
REACTION    Pyrophosphate + D-Fructose 6-phosphate = Orthophosphate +
            D-Fructose 1,6-bisphosphate
SUBSTRATE   Pyrophosphate
            D-Fructose 6-phosphate
PRODUCT     Orthophosphate
            D-Fructose 1,6-bisphosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       SME: SMc01852(pfk)
            CTR: CT205 CT207
            CMU: TC0477 TC0479
            CPN: CPn0160 CPn0208
            CPA: CP0559 CP0611
            CPJ: pfkA_1 pfkA_2
            BBU: BB0020(pfpB) BB0727(pfk)
            TPA: TP0108 TP0542
MOTIF       PS: PS00433  [RK]-x(4)-G-H-x-Q-[QR]-G-G-x(5)-D-R
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.90
            ExPASy - ENZYME nomenclature database: 2.7.1.90
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.90
            BRENDA, the Enzyme Database: 2.7.1.90
///
ENTRY       EC 2.7.1.91
NAME        Sphinganine kinase
            Dihydrosphingosine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:sphinganine 1-phosphotransferase
REACTION    ATP + Sphinganine = ADP + Sphinganine 1-phosphate
SUBSTRATE   ATP
            Sphinganine
PRODUCT     ADP
            Sphinganine 1-phosphate
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.91
            ExPASy - ENZYME nomenclature database: 2.7.1.91
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.91
            BRENDA, the Enzyme Database: 2.7.1.91
///
ENTRY       EC 2.7.1.92
NAME        5-Dehydro-2-deoxygluconokinase
            5-Keto-2-deoxygluconokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase
REACTION    ATP + 5-Dehydro-2-deoxy-D-gluconate = ADP +
            6-Phospho-5-dehydro-2-deoxy-D-gluconate
SUBSTRATE   ATP
            5-Dehydro-2-deoxy-D-gluconate
PRODUCT     ADP
            6-Phospho-5-dehydro-2-deoxy-D-gluconate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.92
            ExPASy - ENZYME nomenclature database: 2.7.1.92
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.92
            BRENDA, the Enzyme Database: 2.7.1.92
///
ENTRY       EC 2.7.1.93
NAME        Alkylglycerol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase
REACTION    ATP + 1-O-Alkyl-sn-glycerol = ADP +
            1-O-Alkyl-sn-glycerol 3-phosphate
SUBSTRATE   ATP
            1-O-Alkyl-sn-glycerol
PRODUCT     ADP
            1-O-Alkyl-sn-glycerol 3-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.93
            ExPASy - ENZYME nomenclature database: 2.7.1.93
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.93
            BRENDA, the Enzyme Database: 2.7.1.93
///
ENTRY       EC 2.7.1.94
NAME        Acylglycerol kinase
            Monoacylglycerol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:acylglycerol 3-phosphotransferase
REACTION    ATP + Acylglycerol = ADP + Acyl-sn-glycerol 3-phosphate
SUBSTRATE   ATP
            Acylglycerol
PRODUCT     ADP
            Acyl-sn-glycerol 3-phosphate
COMMENT     Acts on both 1- and 2-acylglycerols.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.94
            ExPASy - ENZYME nomenclature database: 2.7.1.94
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.94
            BRENDA, the Enzyme Database: 2.7.1.94
///
ENTRY       EC 2.7.1.95
NAME        Kanamycin kinase
            Neomycin-kanamycin phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:kanamycin O3'-phosphotransferase
REACTION    ATP + Kanamycin = ADP + Kanamycin 3'-phosphate
SUBSTRATE   ATP
            Kanamycin
            Neomycin
            Paromomycin
            Neamine
            Paromamine
            Vistamycin
            Gentamicin A
            Bitirosin
PRODUCT     ADP
            Kanamycin 3'-phosphate
COMMENT     Also acts on the antibiotics neomycin, paromomycin, neamine,
            paromamine, vistamycin and gentamicin A. An enzyme from
            Pseudomonas aeruginosa also acts on bitirosin.
GENES       PAE: PA4119(aph)
            MLO: mlr2696
            LLA: L33782(ymdC)
            MTU: Rv3817
            MTC: MT3925.1
            DRA: DR0066
STRUCTURES  PDB: 1J7L  1J7I  1J7U  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.95
            ExPASy - ENZYME nomenclature database: 2.7.1.95
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.95
            BRENDA, the Enzyme Database: 2.7.1.95
///
ENTRY       EC 2.7.1.96
NAME        Deleted entry
            NADH kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry. Now included with EC 2.7.1.86.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.96
            ExPASy - ENZYME nomenclature database: 2.7.1.96
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.96
///
ENTRY       EC 2.7.1.97
NAME        Deleted entry
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry. Identical with EC 2.7.1.125.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.97
            ExPASy - ENZYME nomenclature database: 2.7.1.97
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.97
///
ENTRY       EC 2.7.1.98
NAME        Deleted entry
            Phosphoenolpyruvate--fructose phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.98
            ExPASy - ENZYME nomenclature database: 2.7.1.98
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.98
///
ENTRY       EC 2.7.1.99
NAME        [Pyruvate dehydrogenase (lipoamide)] kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[pyruvate dehydrogenase (lipoamide)] phosphotransferase
REACTION    ATP + [Pyruvate dehydrogenase (lipoamide)] = ADP +
            [Pyruvate dehydrogenase (lipoamide)] phosphate
SUBSTRATE   ATP
            [Pyruvate dehydrogenase (lipoamide)]
PRODUCT     ADP
            [Pyruvate dehydrogenase (lipoamide)] phosphate
COMMENT     A mitochondrial enzyme associated with the pyruvate dehydrogenase
            complex. Phosphorylation inactivates EC 1.2.4.1. See comment on
            EC 2.7.1.37.
GENES       CEL: ZK370.5
            DME: CG8808(Pdk)
            HSA: 5163(PDK1) 5164(PDK2) 5165(PDK3) 5166(PDK4)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.99
            ExPASy - ENZYME nomenclature database: 2.7.1.99
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.99
            BRENDA, the Enzyme Database: 2.7.1.99
///
ENTRY       EC 2.7.1.100
NAME        5-Methylthioribose kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase
REACTION    ATP + S5-Methyl-5-thio-D-ribose = ADP +
            S5-Methyl-5-thio-D-ribose 1-phosphate
SUBSTRATE   ATP
            S5-Methyl-5-thio-D-ribose
PRODUCT     ADP
            S5-Methyl-5-thio-D-ribose 1-phosphate
COMMENT     CTP also acts, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.100
            ExPASy - ENZYME nomenclature database: 2.7.1.100
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.100
            BRENDA, the Enzyme Database: 2.7.1.100
///
ENTRY       EC 2.7.1.101
NAME        Tagatose kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-tagatose 6-phosphotransferase
REACTION    ATP + D-Tagatose = ADP + D-Tagatose 6-phosphate
SUBSTRATE   ATP
            D-Tagatose
PRODUCT     ADP
            D-Tagatose 6-phosphate
PATHWAY     PATH: MAP00052  Galactose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.101
            ExPASy - ENZYME nomenclature database: 2.7.1.101
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.101
            BRENDA, the Enzyme Database: 2.7.1.101
///
ENTRY       EC 2.7.1.102
NAME        Hamamelose kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-hamamelose 2'-phosphotransferase
REACTION    ATP + D-Hamamelose = ADP + D-Hamamelose 2'-phosphate
SUBSTRATE   ATP
            D-Hamamelose
PRODUCT     ADP
            D-Hamamelose 2'-phosphate
COMMENT     Also acts, more slowly, on D-hamamelitol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.102
            ExPASy - ENZYME nomenclature database: 2.7.1.102
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.102
            BRENDA, the Enzyme Database: 2.7.1.102
///
ENTRY       EC 2.7.1.103
NAME        Viomycin kinase
            Viomycin phosphotransferase
            Capreomycin phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:viomycin O-phosphotransferase
REACTION    ATP + Viomycin = ADP + O-Phosphoviomycin
SUBSTRATE   ATP
            Viomycin
            Capreomycin
PRODUCT     ADP
            O-Phosphoviomycin
COMMENT     Acts also on capreomycins. A serine residue in the peptide
            antibiotics acts as phosphate-acceptor
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.103
            ExPASy - ENZYME nomenclature database: 2.7.1.103
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.103
            BRENDA, the Enzyme Database: 2.7.1.103
///
ENTRY       EC 2.7.1.104
NAME        Pyrophosphate--protein phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Pyrophosphate:microsomal-membrane-protein O-phosphotransferase
REACTION    Pyrophosphate + Microsomal-membrane protein = Orthophosphate +
            O-Phospho-microsomal-membrane protein
SUBSTRATE   Pyrophosphate
            Microsomal-membrane protein
PRODUCT     Orthophosphate
            O-Phospho-microsomal-membrane protein
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.104
            ExPASy - ENZYME nomenclature database: 2.7.1.104
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.104
            BRENDA, the Enzyme Database: 2.7.1.104
///
ENTRY       EC 2.7.1.105
NAME        6-Phosphofructo-2-kinase
            Phosphofructokinase 2
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-fructose-6-phosphate 2-phosphotransferase
REACTION    ATP + D-Fructose 6-phosphate = ADP + D-Fructose 2,6-bisphosphate
SUBSTRATE   ATP
            D-Fructose 6-phosphate
PRODUCT     ADP
            D-Fructose 2,6-bisphosphate
COMMENT     Not identical with EC 2.7.1.11. The enzyme co-purifies with
            EC 3.1.3.46.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       SCE: YIL107C(PFK26) YOL136C(PFK27)
            CEL: K02B2.1
            DME: CG3400 CG3400_1
            HSA: 5207(PFKFB1) 5208(PFKFB2) 5209(PFKFB3) 5210(PFKFB4)
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
STRUCTURES  PDB: 2BIF  1BIF  3BIF  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.105
            ExPASy - ENZYME nomenclature database: 2.7.1.105
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.105
            BRENDA, the Enzyme Database: 2.7.1.105
            SCOP (Structural Classification of Proteins): 2.7.1.105
///
ENTRY       EC 2.7.1.106
NAME        Glucose-1,6-bisphosphate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     3-Phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate
            $ 6-phosphotransferase
REACTION    3-Phospho-D-glyceroyl phosphate + D-Glucose 1-phosphate =
            3-Phospho-D-glycerate + D-Glucose 1,6-biphosphate
SUBSTRATE   3-Phospho-D-glyceroyl phosphate
            D-Glucose 1-phosphate
            D-Glucose 6-phosphate
PRODUCT     3-Phospho-D-glycerate
            D-Glucose 1,6-biphosphate
COMMENT     D-Glucose 6-phosphate can act as acceptor, forming D-glucose
            1,6-biphosphate.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.106
            ExPASy - ENZYME nomenclature database: 2.7.1.106
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.106
            BRENDA, the Enzyme Database: 2.7.1.106
///
ENTRY       EC 2.7.1.107
NAME        Diacylglycerol kinase
            Diglyceride kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1,2-diacylglycerol 3-phosphotransferase
REACTION    ATP + 1,2-Diacylglycerol = ADP +
            1,2-Diacyl-sn-glycerol 3-phosphate
SUBSTRATE   ATP
            1,2-Diacylglycerol
PRODUCT     ADP
            1,2-Diacyl-sn-glycerol 3-phosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b4042(dgkA)
            ECE: Z1139 Z1578 Z5641(dgkA)
            ECS: ECs1316 ECs5025
            YPE: YPO0313(dgkA)
            HIN: HI0335(dgkA)
            PMU: PM1864(dgkA)
            XFA: XF2334
            VCH: VCA0714
            PAE: PA3603(dgkA)
            NME: NMB1558
            NMA: NMA1746(dgk)
            HPY: HP0700(dgkA)
            HPJ: jhp0640
            CJE: Cj0257(dgkA)
            MLO: mll0823
            SME: SMc04213(dgkA)
            BSU: BG11040(dgkA)
            BHA: BH1364
            SAU: SA1398
            SAV: SAV1558(dgkA)
            LLA: L95012(dgkA)
            SPY: SPy0475(dgk)
            SPN: SP0968
            SPR: spr0870(dgkA)
            CAC: CAC1294(dgkA/pgpB)
            SYN: slr0054(dgkA)
            DRA: DR2093
            TMA: TM0407
            CEL: F54G8.2
            DME: CG10966(rdgA) CG8657(Dgkepsilon)
            HSA: 1606(DGKA) 1608(DGKG) 1609(DGKQ) 8525(DGKZ) 8526(DGKE)
                 8527(DGKD) 9162(DGKI)
DISEASE     MIM: 125855  Diacylglycerol kinase, alpha, 80kD
            MIM: 601207  Diacylglycerol kinase, theta, 110kD
            MIM: 601440  Diacylglycerol kinase, epsilon, 64-kD
            MIM: 601854  Diacylglycerol kinase, gamma, 90-kD
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00479  H-x-[LIVMFYW]-x(8,11)-C-x(2)-C-x(3)-[LIVMFC]-x(5,10)-C-
                         x(2)-C-x(4)-[HD]-x(2)-C-x(5,9)-C
            PS: PS01069  E-x-[LIVM]-N-[ST]-[SA]-[LIV]-E-x(2)-V-D
            PS: PS50003  PH domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.107
            ExPASy - ENZYME nomenclature database: 2.7.1.107
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.107
            BRENDA, the Enzyme Database: 2.7.1.107
///
ENTRY       EC 2.7.1.108
NAME        Dolichol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     GTP:dolichol O-phosphotransferase
REACTION    GTP + Dolichol = CDP + Dolichyl phosphate
SUBSTRATE   GTP
            Dolichol
PRODUCT     CDP
            Dolichyl phosphate
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YMR013C(SEC59)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.108
            ExPASy - ENZYME nomenclature database: 2.7.1.108
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.108
            BRENDA, the Enzyme Database: 2.7.1.108
///
ENTRY       EC 2.7.1.109
NAME        [Hydroxymethylglutaryl-CoA reductase(NADPH)] kinase
            Reductase kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[dihydroxymethylglutaryl-CoA reductase (NADPH)]
            $ phosphotransferase
REACTION    ATP + [Dihydroxymethylglutaryl-CoA reductase (NADPH)] = ADP +
            [Dihydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
SUBSTRATE   ATP
            [Dihydroxymethylglutaryl-CoA reductase (NADPH)]
PRODUCT     ADP
            [Dihydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
COMMENT     EC 1.1.1.34 is inactivated by the phsophorylation of the enzyme
            protein.  Histones can also act as acceptors.  See comment on
            EC 2.7.1.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.109
            ExPASy - ENZYME nomenclature database: 2.7.1.109
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.109
            BRENDA, the Enzyme Database: 2.7.1.109
///
ENTRY       EC 2.7.1.110
NAME        Dephospho-[reductase kinase] kinase
            Reductase kinase kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:dephopho-[[hydroxymethylglutaryl-CoA reductase (NADPH)]
            $kinase] phopshotransferase
REACTION    ATP +
            Dephopho-[[hydroxymethylglutaryl-CoA reductase (NADPH)]kinase] =
            ADP +
            [[Hydroxymethylglutaryl-CoA reductase (NADPH)]kinase]
SUBSTRATE   ATP
            Dephopho-[[hydroxymethylglutaryl-CoA reductase (NADPH)]kinase]
PRODUCT     ADP
            [[Hydroxymethylglutaryl-CoA reductase (NADPH)]kinase]
COMMENT     Phosphorylates and activates EC 2.7.1.109 which can been
            inactivated by phosphoprotein phosphate (EC 3.1.3.16).  See
            comment on EC 2.7.1.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.110
            ExPASy - ENZYME nomenclature database: 2.7.1.110
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.110
            BRENDA, the Enzyme Database: 2.7.1.110
///
ENTRY       EC 2.7.1.111
NAME        Deleted entry
            [Acetyl-CoA carboxylase] kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
COMMENT     Deleted entry. Now listed as EC 2.7.1.128.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.111
            ExPASy - ENZYME nomenclature database: 2.7.1.111
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.111
///
ENTRY       EC 2.7.1.112
NAME        Protein-tyrosine kinase
            Tyrosylprotein kinase
            Protein kinase (tyrosine)
            Hydroxyaryl-protein kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protein-tyrosine O-phosphotransferase
REACTION    ATP + Protein tyrosine = ADP + Protein tyrosine phosphate
SUBSTRATE   ATP
            Protein tyrosine
            Nucleoside triphosphate
PRODUCT     ADP
            Protein tyrosine phosphate
            Nucleoside diphosphate
COMMENT     There are many eukaryotic genes for this type of enzyme, some of
            which are closely related. Nucleotides other than ATP may also act
            as donors. See comment on EC 2.7.1.37.
GENES       CEL: B0302.1 B0523.1 C16B8.1 F09A5.2 F11D5.3 F49B2.5 F59F3.1
                 M03A1.1(vab-1) abl-1 egl-15 kin-15 kin-16 kin-5 let-23
            DME: CG10023(Fak56D) CG10079(Egfr) CG10239(HD-14) CG1061
                 CG1389(tor) CG1511(Eph) CG1594(hop) CG17559(dnt) CG18085(sev)
                 CG18402(InR) CG3969(PR2) CG4007(Nrk) CG4032 CG4488(wee)
                 CG4926(Ror) CG6714(btl) CG7223(htl) CG7524 CG7525(Tie)
                 CG7873(Src42A) CG8049(Btk29A) CG8874(Fps85D) CG8874_1(Fps85D)
                 CG8967(otk)
            MMU: 101766(Ryk) 101865(Srms) 102960(Txk) 87859(Abl) 88169(Blk)
                 88216(Btk) 88537(Csk) 95276(Epha7) 95294(Egfr) 95481(Fadk)
                 95522(Fgfr1) 95523(Fgfr2) 95524(Fgfr3) 95525(Fgfr4)
                 95559(Flt3) 95561(Flt4) 96052(Hck) 96433(Igf1r) 96575(Insr)
                 96621(Itk) 96629(Jak2) 96638 96677(Kit) 96840(Ltk) 96892(Lyn)
                 97385(Ntrk3) 98277(Epha4) 98397(Src) 98662(Tec) 98664(Tek)
                 99147(Yes) 99216(Cak) 99259(Matk) 99515(Syk) 99613(Zap70)
                 99928(Jak3)
            HSA: 10461(MERTK) 1436(CSF1R) 1445(CSK) 1956(EGFR) 1969(EPHA2)
                 2041(EPHA1) 2042(EPHA3) 2043(EPHA4) 2045(EPHA7) 2047(EPHB1)
                 2049(EPHB3) 2050(EPHB4) 2064(ERBB2) 2065(ERBB3) 2066(ERBB4)
                 2185(PTK2B) 2241(FER) 2242(FES) 2260(FGFR1) 2261(FGFR3)
                 2263(FGFR2) 2264(FGFR4) 2268(FGR) 2321(FLT1) 2322(FLT3)
                 2324(FLT4) 2444(FRK) 25(ABL1) 2534(FYN) 27(ABL2) 3055(HCK)
                 3480(IGF1R) 3643(INSR) 3702(ITK) 3716(JAK1) 3717(JAK2)
                 3718(JAK3) 3723(JTK5A) 3724(JTK5B) 3791(KDR) 3815(KIT)
                 3932(LCK) 4058(LTK) 4067(LYN) 4145(MATK) 4233(MET)
                 4296(MAP3K11) 4486(MST1R) 4914(NTRK1) 4915(NTRK2) 4916(NTRK3)
                 4919(ROR1) 4920(ROR2) 4921(DDR2) 5156(PDGFRA) 5159(PDGFRB)
                 558(AXL) 5747(PTK2) 5750(PTK3B) 5751(PTK4) 5752(PTK5)
                 5753(PTK6) 5754(PTK7) 5755(PTK8) 5979(RET) 6098(ROS1)
                 6259(RYK) 6260(RYKL1) 640(BLK) 660(BMX) 6714(SRC) 6850(SYK)
                 695(BTK) 7006(TEC) 7010(TEK) 7075(TIE) 7294(TXK) 7297(TYK2)
                 7301(TYRO3) 7304(TYRO4) 7465(WEE1) 7525(YES1) 7535(ZAP70)
                 780(DDR1)
DISEASE     MIM: 134934  Fibroblast growth factor receptor-3
            MIM: 147795  Janus kinase 1 (a protein-tyrosine kinase)
            MIM: 153390  Lymphocyte-specific protein tyrosine kinase
            MIM: 164690  Abelson murine leukemia viral (v-abl) oncogene homolog
                         2 (arg,
            MIM: 164920  Hardy-Zuckerman 4 feline sarcoma (v-kit) oncogeneMI
            MIM: 164940  Oncogene FGR
            MIM: 176945  Ephrin receptor EphA8 (eph- and elk-related kinase)
            MIM: 176946  Ephrin receptor EphA2
            MIM: 176947  Zeta-chain associated protein kinase, 70kD
                         (syk-related tyrosine
            MIM: 179611  Ephrin receptor EphA3 (human embryo kinase 1)
            MIM: 191306  Kinase insert domain receptor
            MIM: 191311  Neurotrophic tyrosine kinase, receptor-related 3
            MIM: 191315  Neurotrophic tyrosine kinase, receptor, type 1
            MIM: 600058  TXK tyrosine kinase
            MIM: 600168  Macrophage stimulating 1 receptor (c-met-related
                         tyrosine kinase)
            MIM: 600222  Tyrosine kinase with immunoglobulin and epidermal
                         growth factor
            MIM: 600600  eph tyrosine kinase 2 (ephrin receptor EphB1)
            MIM: 601839  EPH-like tyrosine kinase-2
MOTIF       PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS00109  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-[RSTAC]-x(2)-N-
                         [LIVMFYC](3)
            PS: PS00239  [DN]-[LIV]-Y-x(3)-Y-Y-R
            PS: PS00240  G-x-H-x-N-[LIVM]-V-N-L-L-G-A-C-T
            PS: PS00406  [FY]-[LIV]-G-[DE]-E-A-Q-x-[RKQ](2)-G
            PS: PS00790  F-x-[DN]-x-[GAW]-[GA]-C-[LIVM]-[SA]-[LIVM](2)-[SA]-
                         [LV]-[KRHQ]-[LIVA]-x(3)-[KR]-C-[PSAW]
            PS: PS00791  C-x(2)-[DE]-G-[DEQ]-W-x(2,3)-[PAQ]-[LIVMT]-[GT]-x-C-x-
                         C-x(2)-G-[HFY]-[EQ]
            PS: PS01132  [LM]-[LIVM]-T-E-[GAPQ]-x-[LIVMFYWHQ]-N-[PSTAQ]-x(2)-N-
                         [KR]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01285  [GAS]-W-x(7,15)-[FYW]-[LIV]-x-[LIVFA]-[GSTDEN]-x(6)-
                         [LIVF]-x(2)-[IV]-x-[LIVT]-[QKM]-G
            PS: PS01286  P-x(8,10)-[LM]-R-x-[GE]-[LIVP]-x-G-C
            PS: PS50001  Src homology 2 (SH2) domain profile
            PS: PS50002  Src homology 3 (SH3) domain profile
            PS: PS50003  PH domain profile
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 2FGI  2ABL  1VR2  1SKJ  1SHF  1SHB  1SHA  1SGG  1QWF  1QWE  
                 1QPJ  1QPE  1QPD  1QPC  1QLY  1NYG  1NYF  1NUK  1NLP  1NLO  
                 1LCK  1LCJ  1JWO  1IR3  1IIL  1IIJ  1II4  1IGR  1IEP  1I44  
                 1HE7  1GAG  1G83  1FYN  1FVR  2SRC  1FMK  1FLT  1FGK  3HCK  
                 3LCK  2HCK  2PTK  1EFN  1DNR  1DNQ  1DJS  1CWE  1CSZ  1CSY  
                 1CSK  1BYG  1BWN  1BU1  1BTK  1BLK  1BLJ  1BKM  1BKL  1BHH  
                 1BHF  1B55  1AZG  1AWX  1AWW  1AWO  1AWJ  1AVZ  1AOU  1AOT  
                 1AGW  1AD5  1ABQ  1ABO  1ABL  1AB2  1A81  1A1E  1A1C  1A1B  
                 1A1A  1A0N  1A09  1A08  1A07  1F1W  1FBZ  1F2F  1FGI  1FPU  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.112
            ExPASy - ENZYME nomenclature database: 2.7.1.112
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.112
            BRENDA, the Enzyme Database: 2.7.1.112
            SCOP (Structural Classification of Proteins): 2.7.1.112
///
ENTRY       EC 2.7.1.113
NAME        Deoxyguanosine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:deoxyguanosine 5'-phosphotransferase
REACTION    AMP + Deoxyguanosine = ADP + dGMP
SUBSTRATE   AMP
            Deoxyguanosine
PRODUCT     ADP
            dGMP
COMMENT     Deoxyinosine can also act as acceptor.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       LLA: L169971(dukB) L93481(dukA)
            SPY: SPy0121
            MPU: MYPU_5520(dgk)
            HSA: 1716(DGUOK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.113
            ExPASy - ENZYME nomenclature database: 2.7.1.113
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.113
            BRENDA, the Enzyme Database: 2.7.1.113
///
ENTRY       EC 2.7.1.114
NAME        AMP--thymidine kinase
            Adenylate-nucleoside phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:thymidine 5'-phosphotransferase
REACTION    AMP + Thymidine = Adenosine + Thymidine 5'-phosphate
SUBSTRATE   AMP
            Thymidine
PRODUCT     Adenosine
            Thymidine 5'-phosphate
COMMENT     The deoxypyrimidine kinase complex induced by Herpes simplex
            virus catalyses this reaction as well as those of EC 2.7.1.21,
            2.7.7.118 and 2.7.4.9.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.114
            ExPASy - ENZYME nomenclature database: 2.7.1.114
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.114
            BRENDA, the Enzyme Database: 2.7.1.114
///
ENTRY       EC 2.7.1.115
NAME        [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase
            Branched-chain alpha-ketoacid dehydrogenase kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]
            phosphotransferase
REACTION    ATP + [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] = ADP +
            [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
SUBSTRATE   ATP
            [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]
PRODUCT     ADP
            [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
COMMENT     A mitochondrial enzyme associated with the branched-chain
            2-oxoacid dehydrogenase complex.  Phosphorylation inactivates
            EC 1.2.4.4. See comment on EC 2.7.1.37.
GENES       HSA: 10295(BCKDK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.115
            ExPASy - ENZYME nomenclature database: 2.7.1.115
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.115
            BRENDA, the Enzyme Database: 2.7.1.115
///
ENTRY       EC 2.7.1.116
NAME        [Isocitrate dehydrogenase (NADP+)] kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase
REACTION    ATP + [Isocitrate dehydrogenase (NADP+)] = ADP +
            [Isocitrate dehydrogenase (NADP+)] phosphate
SUBSTRATE   ATP
            [Isocitrate dehydrogenase (NADP+)]
PRODUCT     ADP
            [Isocitrate dehydrogenase (NADP+)] phosphate
COMMENT     Phosphorylates and inactivates EC 1.1.1.42. See comment on
            EC 2.7.1.37.
GENES       YPE: YPO3724(aceK)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.116
            ExPASy - ENZYME nomenclature database: 2.7.1.116
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.116
            BRENDA, the Enzyme Database: 2.7.1.116
///
ENTRY       EC 2.7.1.117
NAME        Myosin-light-chain kinase
            Myosin kinase
            Smooth-muscle-myosin-light-chain kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:myosin-light-chain O-phosphotransferase
REACTION    ATP + Myosin light chain = ADP + Myosin light chain phosphate
SUBSTRATE   ATP
            Myosin light chain
PRODUCT     ADP
            Myosin light chain phosphate
COFACTOR    Ca2+
            Calmodulin
COMMENT     Requires Ca2+ and calmodulin. The 20-kDa light chain from smooth
            muscle myosin is phosphorylated more rapidly than any other
            acceptor, but light chains from other myosins and myosin itself
            can act as acceptors, more slowly.
GENES       HSA: 4638(MYLK)
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 1TLK  1VRK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.117
            ExPASy - ENZYME nomenclature database: 2.7.1.117
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.117
            BRENDA, the Enzyme Database: 2.7.1.117
            SCOP (Structural Classification of Proteins): 2.7.1.117
///
ENTRY       EC 2.7.1.118
NAME        ADP--thymidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ADP:thymidine 5'-phosphotransferase
REACTION    ADP + Thymidine = AMP + Thymidine 5'-phosphate
SUBSTRATE   ADP
            Thymidine
PRODUCT     AMP
            Thymidine 5'-phosphate
COMMENT     The deoxypyrimidine kinase complex induced by Herpes simplex virus
            catalyses this reaction as well as those of EC 2.7.1.21, 2.7.1.114
            and 2.7.4.9.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.118
            ExPASy - ENZYME nomenclature database: 2.7.1.118
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.118
            BRENDA, the Enzyme Database: 2.7.1.118
///
ENTRY       EC 2.7.1.119
NAME        Hygromycin-B kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:hygromycin-B 7''-O-phosphotransferase
REACTION    ATP + Hygromycin B = ADP + 7''-O-Phosphohygromycin
SUBSTRATE   ATP
            Hygromycin B
            1-N-Hydromicin
            Destomysin
PRODUCT     ADP
            7''-O-Phosphohygromycin
COMMENT     Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B
            and destomycin, but not hygromycin B2, at the 7''-hydroxyl group
            in the destomic acid ring.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.119
            ExPASy - ENZYME nomenclature database: 2.7.1.119
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.119
            BRENDA, the Enzyme Database: 2.7.1.119
///
ENTRY       EC 2.7.1.120
NAME        Caldesmon kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:Caldesmon O-phosphotransferase
REACTION    ATP + Caldesmon = ADP + Caldesmon phosphate
SUBSTRATE   ATP
            Caldesmon
PRODUCT     ADP
            Caldesmon phosphate
EFFECTOR    Calcium
            Calmodulin
COMMENT     Requires Ca2+ and calmodulin. Phosphorylation abolishes the
            ability of the protein caldesmon to bind actin and inhibit ATPase.
            The enzyme appears to be identical with caldesmon; the reaction is
            an autophosphorylation.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.120
            ExPASy - ENZYME nomenclature database: 2.7.1.120
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.120
            BRENDA, the Enzyme Database: 2.7.1.120
///
ENTRY       EC 2.7.1.121
NAME        Phosphoenolpyruvate--glycerone phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     Phosphoenolpyruvate:glycerone phosphotransferase
REACTION    Phosphoenolpyruvate + Glycerone = Pyruvate + Glycerone phosphate
SUBSTRATE   Phosphoenolpyruvate
            Glycerone
PRODUCT     Pyruvate
            Glycerone phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.121
            ExPASy - ENZYME nomenclature database: 2.7.1.121
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.121
            BRENDA, the Enzyme Database: 2.7.1.121
///
ENTRY       EC 2.7.1.122
NAME        Xylitol kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:xylitol 5-phosphotransferase
REACTION    ATP + Xylitol = ADP + Xylitol 5-phosphate
SUBSTRATE   ATP
            Xylitol
PRODUCT     ADP
            Xylitol 5-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.122
            ExPASy - ENZYME nomenclature database: 2.7.1.122
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.122
            BRENDA, the Enzyme Database: 2.7.1.122
///
ENTRY       EC 2.7.1.123
NAME        Ca2+/calmodulin-dependent protein kinase
            Microtubule-associated protein 2 kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:protein O-phosphotransferase (calmodulin-dependent)
REACTION    ATP + Protein = ADP + O-Phosphoprotein
SUBSTRATE   ATP
            Protein
            Vimentin
            Synapsin
            Glycogen synthase
            Myosin light chain
PRODUCT     ADP
            O-Phosphoprotein
COFACTOR    Calmodulin
            Ca2+
COMMENT     Requires calmodulin and Ca2+. A wide range of proteins can act as
            acceptor, including vimentin, synapsin, glycogen synthases,
            myosin light chains and the microtubule-associated tau protein.
            Not identical with EC 2.7.1.117, 2.7.1.120 or 2.7.1.135.
GENES       SCE: YFR014C(CMK1) YOL016C(CMK2)
            CEL: unc-43
            DME: CG13412(Caki) CG1495(CaMKI) CG1495_1(CaMKI) CG18069(CaMKII)
                 CG6703(cmg) CG8304(Mlc-k)
            MMU: 88257(Camk2b) 88258(Camk4)
            HSA: 814(CAMK4) 816(CAMK2B) 8536(CAMK1)
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 1A06  1CM4  1CM1  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.123
            ExPASy - ENZYME nomenclature database: 2.7.1.123
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.123
            BRENDA, the Enzyme Database: 2.7.1.123
            SCOP (Structural Classification of Proteins): 2.7.1.123
///
ENTRY       EC 2.7.1.124
NAME        Tyrosine 3-monooxygenase kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[L-tyrosine,tetrahydropteridine:oxygen oxidoreductase
            $(3-hydroxylating)] O-phosphotransferase
REACTION    ATP + [Tyrosine-3-monoxygenase] = ADP +
            Phospho-[tyrosine-3-monoxygenase]
SUBSTRATE   ATP
            [Tyrosine-3-monoxygenase]
PRODUCT     ADP
            Phospho-[tyrosine-3-monoxygenase]
COMMENT     Activates EC 1.14.16.2 by phosphorylation.  Specific for this
            substrate, with which it co-purifies.  See comment on EC 2.7.2.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.124
            ExPASy - ENZYME nomenclature database: 2.7.1.124
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.124
            BRENDA, the Enzyme Database: 2.7.1.124
///
ENTRY       EC 2.7.1.125
NAME        Rhodopsin kinase
            Opsin kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:rhodopsin phosphotransferase
REACTION    ATP + Rhodopsin = ADP + Phosphorhodopsin
SUBSTRATE   ATP
            Rhodopsin
            beta-Adrenergic receptor
PRODUCT     ADP
            Phosphorhodopsin
INHIBITOR   Zn2+
            Digitonin
COMMENT     Acts on the bleached or activated form of rhodopsin; also
            phosphorylates the beta-adrenergic receptor, but more slowly.
            Does not act on casein, histones or phosphvitin. Inhibited by
            Zn2+ and Digitonin. (cf. EC 2.7.1.126)
GENES       HSA: 6011(RHOK)
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50011  Protein kinase domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.125
            ExPASy - ENZYME nomenclature database: 2.7.1.125
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.125
            BRENDA, the Enzyme Database: 2.7.1.125
///
ENTRY       EC 2.7.1.126
NAME        beta-Adrenergic-receptor kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:beta-adrenergic-receptor phosphotransferase
REACTION    ATP + beta-Adrenergic receptor =
            ADP + Phospho-beta-adrenergic receptor
SUBSTRATE   ATP
            beta-Adrenergic receptor
            Rhodopsin
PRODUCT     ADP
            Phospho-beta-adrenergic receptor
INHIBITOR   Zn2+
            Digitonin
COMMENT     Acts on the agonist-occupied form of the receptor; also
            phosphorylates rhodopsin, but more slowly. Does not act on casein
            or histones. Inhibited by Zn2+ and digitonin; unaffected by
            cyclic-AMP. (cf. EC 2.7.1.125). See comment on EC 2.7.1.37.
GENES       HSA: 156(ADRBK1) 157(ADRBK2)
DISEASE     MIM: 109635  Adrenergic, beta, receptor kinase-1
            MIM: 109636  Adrenergic, beta, receptor kinase-2
MOTIF       PS: PS00107  [LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-
                         x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-
                         [LIVMFAGCKR]-K
            PS: PS00108  [LIVMFYC]-x-[HY]-x-D-[LIVMFY]-K-x(2)-N-[LIVMFYCT](3)
            PS: PS50003  PH domain profile
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 1BAK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.126
            ExPASy - ENZYME nomenclature database: 2.7.1.126
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.126
            BRENDA, the Enzyme Database: 2.7.1.126
            SCOP (Structural Classification of Proteins): 2.7.1.126
///
ENTRY       EC 2.7.1.127
NAME        1D-myo-Inositol-triphosphate 3-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 1,4,5-trisphosphate = ADP +
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 1,4,5-trisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
EFFECTOR    Ca2+
COMMENT     Activated by Ca2+.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       HSA: 3706(ITPKA)
DISEASE     MIM: 147521  Inositol 1,4,5-trisphosphate 3-kinase A
            MIM: 147522  Inositol 1,4,5-trisphosphate 3-kinase B
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.127
            ExPASy - ENZYME nomenclature database: 2.7.1.127
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.127
            BRENDA, the Enzyme Database: 2.7.1.127
///
ENTRY       EC 2.7.1.128
NAME        [Acetyl-CoA carboxylase] kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[acetyl-CoA carboxylase] phosphotransferase
REACTION    ATP + [Acetyl-CoA carboxylase] = ADP +
            [Acetyl-CoA carboxylase] phosphate
SUBSTRATE   ATP
            [Acetyl-CoA carboxylase]
PRODUCT     ADP
            [Acetyl-CoA carboxylase] phosphate
COMMENT     Phosphorylates and inactivates EC 6.4.1.2.  See comment on
            EC 2.7.1.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.128
            ExPASy - ENZYME nomenclature database: 2.7.1.128
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.128
            BRENDA, the Enzyme Database: 2.7.1.128
///
ENTRY       EC 2.7.1.129
NAME        Myosin-heavy-chain kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:myosin-heavy-chain O-phosphotransferase
REACTION    ATP + Myosin heavy chain = ADP + Myosin heavy-chain phosphate
SUBSTRATE   ATP
            Myosin heavy chain
PRODUCT     ADP
            Myosin heavy-chain phosphate
COMMENT     The enzyme from Dictyostelium sp. brings about phosphorylation of
            the heavy chain of Dictyostelium myosin, inhibiting the actin-
            activated ATPase activity of the myosin.  One threonine residue
            in each heavy chain acts as acceptor.
GENES       HSA: 4630(MYHK)
MOTIF       PS: PS00479  H-x-[LIVMFYW]-x(8,11)-C-x(2)-C-x(3)-[LIVMFC]-x(5,10)-C-
                         x(2)-C-x(4)-[HD]-x(2)-C-x(5,9)-C
            PS: PS00678  [LIVMSTAC]-[LIVMFYWSTAGC]-[LIMSTAG]-[LIVMSTAGC]-x(2)-
                         [DN]-x(2)-[LIVMWSTAC]-x-[LIVMFSTAG]-W-[DEN]-
                         [LIVMFSTAGCN]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.129
            ExPASy - ENZYME nomenclature database: 2.7.1.129
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.129
            BRENDA, the Enzyme Database: 2.7.1.129
///
ENTRY       EC 2.7.1.130
NAME        Tetraacyldisaccharide 4'-kinase
            Lipid-A 4'-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-
            $beta-D-1,6-glucosaminyl-beta-phosphate 4-O'-phosphotransferase
REACTION    ATP +
            2,3-Bis-(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-
            $bis(3-hydroxy-tetradecanoyl)-D-glucosaminyl beta-phosphate =
            ADP +
            2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-
            $beta-D-glucosamine 1,4'-bisphosphate
SUBSTRATE   ATP
            2,3-Bis-(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-
            $bis(3-hydroxy-tetradecanoyl)-D-glucosaminyl beta-phosphate
PRODUCT     ADP
            2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-
            $beta-D-glucosamine 1,4'-bisphosphate
COMMENT     Involved with EC 2.3.1.129 and 2.4.1.182 in the biosynthesis of
            the phosphorylated glycolipid, Lipid A, in the outer membrane of
            Escherichia coli.
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b0915(lpxK)
            ECE: Z1261(ycaH)
            ECS: ECs0998
            YPE: YPO1396(lpxK)
            HIN: HI0059
            PMU: PM0860(lpxK)
            XFA: XF1082
            VCH: VC1877
            PAE: PA2981(lpxK)
            NME: NMB0672
            NMA: NMA0872(lpxK)
            HPY: HP0328
            HPJ: jhp0311
            CJE: Cj0811(lpxK)
            RPR: RP719
            RCO: RC1092(lpxK)
            MLO: mlr8270
            SME: SMc00892(lpxK)
            CCR: CC0301
            CTR: CT402
            CMU: TC0682
            CPN: CPn0529
            CPA: CP0223
            CPJ: ycaH
            AAE: aq_1656
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.130
            ExPASy - ENZYME nomenclature database: 2.7.1.130
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.130
            BRENDA, the Enzyme Database: 2.7.1.130
///
ENTRY       EC 2.7.1.131
NAME        Low-density-lipoprotein kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:low-density-lipoprotein-L-serine O-phosphotransferase
REACTION    ATP + Low-density lipoprotein L-serine = ADP +
            Low-density lipoprotein O-phospho-L-serine
SUBSTRATE   ATP
            Low-density lipoprotein L-serine
PRODUCT     ADP
            Low-density lipoprotein O-phospho-L-serine
COMMENT     Phosphorylates the serine-833 in the cytoplasmic domain of the
            low-density lipoprotein receptor.  GTP can act instead of ATP.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.131
            ExPASy - ENZYME nomenclature database: 2.7.1.131
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.131
            BRENDA, the Enzyme Database: 2.7.1.131
///
ENTRY       EC 2.7.1.132
NAME        Tropomyosin kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:tropomyosin O-phosphotransferase
REACTION    ATP + Tropomyosin = ADP + O-Phosphotropomyosin
SUBSTRATE   ATP
            Tropomyosin
PRODUCT     ADP
            O-Phosphotropomyosin
COMMENT     Also phosphorylates casein.  The acceptor is a serine residue in
            the protein.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.132
            ExPASy - ENZYME nomenclature database: 2.7.1.132
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.132
            BRENDA, the Enzyme Database: 2.7.1.132
///
ENTRY       EC 2.7.1.133
NAME        1D-myo-Inositol-trisphosphate 6-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 1,3,4-trisphosphate = ADP +
            1D-myo-Inositol 1,3,4,6-tetrakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 1,3,4-trisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,6-tetrakisphosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.133
            ExPASy - ENZYME nomenclature database: 2.7.1.133
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.133
            BRENDA, the Enzyme Database: 2.7.1.133
///
ENTRY       EC 2.7.1.134
NAME        1D-myo-Inositol-tetrakisphosphate 1-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate
            $ 1-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 3,4,5,6-tetrakisphosphate = ADP +
            1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 3,4,5,6-tetrakisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.134
            ExPASy - ENZYME nomenclature database: 2.7.1.134
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.134
            BRENDA, the Enzyme Database: 2.7.1.134
///
ENTRY       EC 2.7.1.135
NAME        Tau-protein kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:tau-protein O-phosphotransferase
REACTION    ATP + tau-Protein = ADP + O-Phospho-tau-protein
SUBSTRATE   ATP
            tau-Protein
PRODUCT     ADP
            O-Phospho-tau-protein
EFFECTOR    Tublin
COMMENT     Activated by tublin.  DIfferent from EC 2.7.1.123: not activated
            by calmodulin, cyclic nucleotides or Ca2+.  Involved in the
            formation of paired helical filaments in brain.  See comment on
            EC 2.7.1.37.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.135
            ExPASy - ENZYME nomenclature database: 2.7.1.135
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.135
            BRENDA, the Enzyme Database: 2.7.1.135
///
ENTRY       EC 2.7.1.136
NAME        Macrolide 2'-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:macrolide 2'-O-phosphotransferase
REACTION    ATP + Oleandomycin = ADP + Oleandomycin 2'-O-phosphate
SUBSTRATE   ATP
            Oleandomycin
            Erythromycin
            Spiramycin
PRODUCT     ADP
            Oleandomycin 2'-O-phosphate
COMMENT     Erythromycin, spiramycin and some other macrolide antibiotics can
            also act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.136
            ExPASy - ENZYME nomenclature database: 2.7.1.136
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.136
            BRENDA, the Enzyme Database: 2.7.1.136
///
ENTRY       EC 2.7.1.137
NAME        1-Phosphatidylinositol 3-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
REACTION    ATP + 1-Phosphatidyl-1D-myo-inositol =
            ADP + 1-Phosphatidyl-1D-myo-inositol 3-phosphate
SUBSTRATE   ATP
            1-Phosphatidyl-1D-myo-inositol
PRODUCT     ADP
            1-Phosphatidyl-1D-myo-inositol 3-phosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       SCE: YJR066W(TOR1) YKL203C(TOR2) YLR240W(VPS34)
            SPO: SPO39 VPS34(vps34)
            ATH: At1g60490(F8A5.4)
            CEL: B0025.1
            DME: CG11621(Pi3K68D) CG2699(Pi3K21B) CG4141(Pi3K92E)
                 CG5373(Pi3K59F)
            HSA: 5287(PIK3C2B) 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD)
                 5294(PIK3CG)
DISEASE     MIM: 171834  Phosphatidylinositol 3-kinase, catalytic, alpha
                         polypeptide
MOTIF       PS: PS00915  [LIVMFAC]-K-x(1,3)-[DEA]-[DE]-[LIVMC]-R-Q-[DE]-x(4)-Q
            PS: PS00916  [GS]-x-[AV]-x(3)-[LIVM]-x(2)-[FYH]-[LIVM](2)-x-[LIVMF]-
                         x-D-R-H-x(2)-N
            PS: PS50004  C2-domain profile
STRUCTURES  PDB: 1PKS  1PIC  1HE8  1E90  1E8Z  1PKT  2PNA  1E8W  1E7V  1E7U  
                 1E8Y  1E8X  2PNB  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.137
            ExPASy - ENZYME nomenclature database: 2.7.1.137
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.137
            BRENDA, the Enzyme Database: 2.7.1.137
            SCOP (Structural Classification of Proteins): 2.7.1.137
///
ENTRY       EC 2.7.1.138
NAME        Ceramide kinase
            Acylsphingosine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:ceramide 1-phosphotransferase
REACTION    ATP + Ceramide = ADP + Ceramide 1-phosphate
SUBSTRATE   ATP
            Ceramide
PRODUCT     ADP
            Ceramide 1-phosphate
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.138
            ExPASy - ENZYME nomenclature database: 2.7.1.138
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.138
            BRENDA, the Enzyme Database: 2.7.1.138
///
ENTRY       EC 2.7.1.139
NAME        1D-myo-Inositol-trisphosphate 5-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 1,3,4-trisphosphate = ADP +
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 1,3,4-trisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.139
            ExPASy - ENZYME nomenclature database: 2.7.1.139
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.139
            BRENDA, the Enzyme Database: 2.7.1.139
///
ENTRY       EC 2.7.1.140
NAME        1D-myo-Inositol-tetrakisphosphate 5-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase
REACTION    ATP + 1D-myo-Inositol 1,3,4,6-tetrakisphosphate = ADP +
            1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
SUBSTRATE   ATP
            1D-myo-Inositol 1,3,4,6-tetrakisphosphate
PRODUCT     ADP
            1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.140
            ExPASy - ENZYME nomenclature database: 2.7.1.140
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.140
            BRENDA, the Enzyme Database: 2.7.1.140
///
ENTRY       EC 2.7.1.141
NAME        [RNA-polymerase]-subunit kinase
            CTD kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:[DNA-directed RNA polymerase] phosphotransferase
REACTION    ATP + [DNA-directed RNA polymerase] = ADP +
            Phospho-[DNA-directed RNA polymerase]
SUBSTRATE   ATP
            [DNA-directed RNA polymerase]
PRODUCT     ADP
            Phospho-[DNA-directed RNA polymerase]
COMMENT     The enzyme appears to be distinct from other protein
            phosphokinases.  It brings about multiple phosphorylation of the
            unique C-terminal repeat domain of the largest subunit of
            eukaryotic EC 2.7.7.6.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.141
            ExPASy - ENZYME nomenclature database: 2.7.1.141
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.141
            BRENDA, the Enzyme Database: 2.7.1.141
///
ENTRY       EC 2.7.1.142
NAME        Glycerol-3-phosphate--glucose phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     sn-Glycerol-3-phosphate:D-glucose 6-phosphotransferas
REACTION    sn-Glycerol 3-phosphate + D-Glucose = Glycerol +
            D-Glucose 6-phosphate
SUBSTRATE   sn-Glycerol 3-phosphate
            D-Glucose
PRODUCT     Glycerol
            D-Glucose 6-phosphate
COMMENT     Involved in the anaerobic metabolism of sugars in the bloodstream
            of trypanosomes.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.142
            ExPASy - ENZYME nomenclature database: 2.7.1.142
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.142
            BRENDA, the Enzyme Database: 2.7.1.142
///
ENTRY       EC 2.7.1.143
NAME        Diphosphate-Purine nucleoside kinase
            Pyrophosphate-Purine nucleoside kinase
            Pyrophosphate-dependent nucleoside kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
REACTION    Diphosphate + Purine nucleoside = Phosphate +
            Purine mononucleoside
SUBSTRATE   Diphosphate
            Purine nucleoside
PRODUCT     Phosphate
            Purine mononucleoside
COMMENT     The enzyme from the Acholeplasma class of mollicutes catalyses
            the conversion of Adenosine, Guanosine and Inosine to AMP, GMP
            and IMP
            ATP cannot substitute for Diphosphate as a substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.143
            ExPASy - ENZYME nomenclature database: 2.7.1.143
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.143
///
ENTRY       EC 2.7.1.144
NAME        Tagatose-6-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with an alcohol group as acceptor
SYSNAME     ATP:D-tagatose-6-phosphate 1-phosphotransferase
REACTION    D-Tagatose 6-phosphate + ATP = D-Tagatose 1,6-bisphosphate + ADP
SUBSTRATE   D-Tagatose 6-phosphate
            ATP
PRODUCT     D-Tagatose 1,6-bisphosphate
            ADP
GENES       ECO: b2095(gatZ) b3132(agaZ)
            ECE: Z3258(gatZ) Z4484(agaZ)
            ECS: ECs2898 ECs4010
            YPE: YPO0832(agaZ)
            MLO: mll7215
            SAU: SA1995(lacC)
            SAV: SAV2179(lacC)
            SPY: SPy1921(lacC.2)
            SPN: SP1191
            SPR: spr1074(lacC)
            CAC: CAC2951(lacC)
MOTIF       PS: PS00583  [AG]-G-x(0,1)-[GAP]-x-N-x-[STA]-x(6)-[GS]-x(9)-G
            PS: PS00584  [DNSK]-[PSTV]-x-[SAG](2)-[GD]-D-x(3)-[SAGV]-[AG]-
                         [LIVMFYA]-[LIVMSTAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.1.144
            ExPASy - ENZYME nomenclature database: 2.7.1.144
            WIT (What Is There) Metabolic Reconstruction: 2.7.1.144
///
ENTRY       EC 2.7.2.1
NAME        Acetate kinase
            Acetokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:acetate phosphotransferase
REACTION    ATP + Acetate = ADP + Acetyl phosphate
SUBSTRATE   ATP
            Acetate
            Propanoate
PRODUCT     ADP
            Acetyl phosphate
            Propanoyl phosphate
COMMENT     Propanoate also acts as acceptor, but more slowly.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       ECO: b2296(ackA)
            ECE: Z3558(ackA)
            ECS: ECs3180
            YPE: YPO2566(ackA)
            HIN: HI1204(ackA)
            PMU: PM0704(ackA)
            VCH: VC1098 VCA0235
            PAE: PA0836
            BUC: BU175(ackA)
            NME: NMB0435 NMB1518
            NMA: NMA1718(ackA1) NMA2050(ackA2)
            HPJ: jhp0840
            CJE: Cj0689(ackA)
            RPR: RP110(ackA)
            MLO: mlr6576
            SME: SMb21184(ackA2)
            BSU: BG10813(ackA)
            BHA: BH3192(ackA)
            SAU: SA1533(ackA)
            SAV: SAV1697(ackA)
            LLA: L0224(ackA2) L73818(ackA1)
            SPY: SPy0109(ackA)
            SPN: SP2044
            SPR: spr1854(ackA)
            CAC: CAC1743(askA)
            MGE: MG357(ackA)
            MPN: G12_orf390(ackA)
            MPU: MYPU_2380(ackA)
            UUR: UU484(ackA)
            MTU: Rv0409(ackA)
            MTC: MT0422
            BBU: BB0622(ackA)
            TPA: TP0476
            SYN: sll1299(ackA)
            DRA: DR2602
            TMA: TM0274
MOTIF       PS: PS01075  [LIVFMA]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]
            PS: PS01076  [LIVMATQ]-[LIVMA]-x(2)-H-x-G-x-G-x-[ST]-[LIVMA]-x-
                         [AVC]-x(3)-G
STRUCTURES  PDB: 1G99  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.1
            ExPASy - ENZYME nomenclature database: 2.7.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.1
            UM-BBD (Biocatalysis/Biodegradation Database): 2.7.2.1
            BRENDA, the Enzyme Database: 2.7.2.1
            SCOP (Structural Classification of Proteins): 2.7.2.1
///
ENTRY       EC 2.7.2.2
NAME        Carbamate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:carbamate phosphotransferase
REACTION    ATP + NH3 + CO2 = ADP + Carbamoyl phosphate
SUBSTRATE   ATP
            NH3
            CO2
PRODUCT     ADP
            Carbamoyl phosphate
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0323(yahI) b0521(arcC) b2874(yqeA)
            ECE: Z0412(yahI) Z0676(arcC) Z4213(yqeA)
            ECS: ECs0372 ECs0583 ECs3747
            HIN: HI0595(arcC)
            PAE: PA5173(arcC)
            SME: SMa0697(arcC)
            SAU: SA1013 SA2425(arcC)
            SAV: SAV1154 SAV2616(arcC)
            LLA: L0112(arcC3) L92850(arcC2) L93826(arcC1)
            SPY: SPy1541(arcC)
            SPN: SP2151
            SPR: spr1958(arcC)
            MPN: F10_orf309(arcC)
            SYN: sll0573(arcC)
            HAL: VNG6316G(arcC)
            TAC: Ta1350
            TVO: TVG0273901
            PHO: PH1282
            PAB: PAB0593(cpa)
            APE: APE1968
STRUCTURES  PDB: 1B7B  1E19  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.2
            ExPASy - ENZYME nomenclature database: 2.7.2.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.2
            BRENDA, the Enzyme Database: 2.7.2.2
            SCOP (Structural Classification of Proteins): 2.7.2.2
///
ENTRY       EC 2.7.2.3
NAME        Phosphoglycerate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:3-phospho-D-glycerate 1-phosphotransferase
REACTION    ATP + 3-Phospho-D-glycerate = ADP +
            3-Phospho-D-glyceroyl phosphate
SUBSTRATE   ATP
            3-Phospho-D-glycerate
PRODUCT     ADP
            3-Phospho-D-glyceroyl phosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00710  Carbon fixation
GENES       ECO: b2926(pgk)
            ECE: Z4265(pgk)
            ECS: ECs3797
            YPE: YPO0921(pgk)
            HIN: HI0525(pgk)
            PMU: PM1860(pgk)
            XFA: XF0823
            VCH: VC0477
            PAE: PA0552(pgk)
            BUC: BU450(pgk)
            NME: NMB0010
            NMA: NMA0257(pgk)
            HPY: HP1345(pgk)
            HPJ: jhp1264
            CJE: Cj1402c(pgk)
            MLO: mlr3753
            SME: SMc03981(pgk)
            CCR: CC3249
            BSU: BG11062(pgk)
            BHA: BH3559(pgk)
            SAU: SA0728(pgk)
            SAV: SAV0760(pgk)
            LLA: L0010(pgk)
            SPY: SPy1881(pgk)
            SPN: SP0499
            SPR: spr0441(pgk)
            CAC: CAC0710(pgk)
            MGE: MG300(pgk)
            MPN: A05_orf409(pgk)
            MPU: MYPU_2460(pgk)
            UUR: UU279(pgk)
            MTU: Rv1437(pgk)
            MTC: MT1481
            MLE: ML0571(pgk)
            CTR: CT693
            CMU: TC0065
            CPN: CPn0679
            CPA: CP0068
            CPJ: pgk
            BBU: BB0056(pgk)
            TPA: TP0538
            SYN: slr0394(pgk)
            DRA: DR1342
            AAE: aq_118(pgk)
            TMA: TM0689
            MJA: MJ0641(pgk)
            MTH: MTH1042
            AFU: AF1146(pgk)
            HAL: VNG1216G(pgk)
            TAC: Ta1075
            TVO: TVG0521991
            PHO: PH1218
            PAB: PAB1679(pgk)
            APE: APE0173
            SSO: SSO0527
            STO: ST1357
            SCE: YCR012W(PGK1)
            SPO: PGK1(pgk1)
            ATH: At1g79550(T8K14.3)
            CEL: T03F1.3
            DME: CG3127(Pgk)
            MMU: 97555(Pgk1) 97563(Pgk2)
            HSA: 5230(PGK1) 5233(PGK2)
DISEASE     MIM: 172270  Phosphoglycerate kinase-2 (testicular PGK)
            MIM: 311800  Phosphoglycerate kinase-1
MOTIF       PS: PS00111  [KRHGTCVN]-[VT]-[LIVMF]-[LIVMC]-R-x-D-x-N-[SACV]-P
STRUCTURES  PDB: 13PK  16PK  1FW8  1HDI  1PHP  1QPG  1VPE  2PGK  3PGK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.3
            ExPASy - ENZYME nomenclature database: 2.7.2.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.3
            BRENDA, the Enzyme Database: 2.7.2.3
            SCOP (Structural Classification of Proteins): 2.7.2.3
///
ENTRY       EC 2.7.2.4
NAME        Aspartate kinase
            Aspartokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:L-aspartate 4-phosphotransferase
REACTION    ATP + L-Aspartate = ADP + 4-Phospho-L-aspartate
SUBSTRATE   ATP
            L-Aspartate
PRODUCT     ADP
            4-Phospho-L-aspartate
COMMENT     The enzyme from E.coli is a multifunctional protein, which also
            catalyses the reaction of EC 1.1.1.3.
            (EC 1.1.1.3 Homoserine dehydrogenase)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b0002(thrA) b3940(metL) b4024(lysC)
            ECE: Z0002(thrA) Z5495(metL) Z5622(lysC)
            ECS: ECs0002 ECs4869 ECs5007
            YPE: YPO0116(metL) YPO0459(thrA) YPO3719(lysC)
            HIN: HI0089(thrA)
            PMU: PM0113(thrA) PM0937
            XFA: XF1116 XF2225
            VCH: VC0391 VC0547 VC2364 VC2684 VCA0822
            PAE: PA0904(lysC)
            BUC: BU194(thrA)
            NME: NMB1498
            NMA: NMA1701(lysC)
            HPY: HP1229(lysC)
            HPJ: jhp1150
            CJE: Cj0582(lysC)
            RPR: RP753(lysC)
            RCO: RC1164(lysC)
            MLO: mll3437
            SME: SMc02438(lysC)
            CCR: CC0843
            BSU: BG10350(lysC) BG10784(dapG) BG12033(yclM)
            BHA: BH1500 BH2400(dapG) BH3096(lysC)
            SAU: SA1163 SA1225(lysC)
            SAV: SAV1312 SAV1378(lysC)
            LLA: L0097(thrA)
            SPN: SP0413
            SPR: spr0374(lysC)
            CAC: CAC0278 CAC1810(dapG)
            MTU: Rv3709c(ask)
            MTC: MT3812
            MLE: ML2323(ask)
            CTR: CT362
            CMU: TC0641
            CPN: CPn1049
            CPA: CP0803
            CPJ: lysC
            SYN: slr0657(lysC)
            DRA: DR1365
            AAE: aq_1152(lysC)
            TMA: TM0547 TM1518
            MJA: MJ0571
            MTH: MTH802
            AFU: AF0700(lysC)
            HAL: VNG2374G(lysC)
            TAC: Ta0364
            PHO: PH0858
            PAB: PAB1675(lysC)
            APE: APE1140
            SSO: SSO0876(akH)
            STO: ST1241
            SCE: YER052C(HOM3)
            SPO: SPBC19F5.04(spbc19f5.04)
MOTIF       PS: PS00324  [LIVM]-x-K-[FY]-G-G-[ST]-[SC]-[LIVM]
            PS: PS01042  A-x(3)-G-[LIVMFY]-[STAG]-x(2,3)-[DNS]-P-x(2)-D-[LIVM]-
                         x-G-x-D-x(3)-K
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.4
            ExPASy - ENZYME nomenclature database: 2.7.2.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.4
            BRENDA, the Enzyme Database: 2.7.2.4
///
ENTRY       EC 2.7.2.5
NAME        Transferred to EC 6.3.4.16
            Carbamoyl-phosphate synthase (ammonia)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
COMMENT     Transferred entry. Now EC 6.3.4.16 - Carbamoyl-phosphate synthase
            (ammonia).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.5
            ExPASy - ENZYME nomenclature database: 2.7.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.5
///
ENTRY       EC 2.7.2.6
NAME        Formate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:formate phosphotransferase
REACTION    ATP + Formate = ADP + Formyl phosphate
SUBSTRATE   ATP
            Formate
PRODUCT     ADP
            Formyl phosphate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.6
            ExPASy - ENZYME nomenclature database: 2.7.2.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.6
            BRENDA, the Enzyme Database: 2.7.2.6
///
ENTRY       EC 2.7.2.7
NAME        Butyrate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:butyrate 1-phosphotransferase
REACTION    ATP + Butanoate = ADP + Butanoyl phosphate
SUBSTRATE   ATP
            Butanoate
PRODUCT     ADP
            Butanoyl phosphate
COMMENT     The enzyme from Clostridium sp. also acts, more slowly, on
            pentanoate and propanoate, and on some branched-chain fatty acids
            (cf. EC 2.7.1.14).
PATHWAY     PATH: MAP00650  Butanoate metabolism
GENES       BSU: BG11724(buk)
            CAC: CAC1660 CAC3075(buk)
            TMA: TM1754 TM1756
MOTIF       PS: PS01075  [LIVFMA]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]
            PS: PS01076  [LIVMATQ]-[LIVMA]-x(2)-H-x-G-x-G-x-[ST]-[LIVMA]-x-
                         [AVC]-x(3)-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.7
            ExPASy - ENZYME nomenclature database: 2.7.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.7
            BRENDA, the Enzyme Database: 2.7.2.7
///
ENTRY       EC 2.7.2.8
NAME        Acetylglutamate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:N-acetyl-L-glutamate 5-phosphotransferase
REACTION    ATP + N-Acetyl-L-glutamate =
            ADP + N-Acetyl-L-glutamate 5-phosphate
SUBSTRATE   ATP
            N-Acetyl-L-glutamate
PRODUCT     ADP
            N-Acetyl-L-glutamate 5-phosphate
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b3959(argB)
            ECE: Z5517(argB)
            ECS: ECs4888
            YPE: YPO3925(argB)
            PMU: PM1119(argB)
            XFA: XF1001
            VCH: VC2643
            PAE: PA5323(argB)
            BUC: BU049(argB)
            NME: NMB1074
            NMA: NMA1275(argB)
            CJE: Cj0226(argB)
            MLO: mlr4826
            SME: SMc01726(argB)
            CCR: CC0283
            BSU: BG10193(argB)
            BHA: BH2898(argB)
            SAU: SA0176
            SAV: SAV0177(argB)
            LLA: L0107(argB)
            CAC: CAC2389(argB)
            MTU: Rv1654(argB)
            MTC: MT1692
            MLE: ML1408(argB)
            SYN: slr1898(argB)
            DRA: DR1420 DR2442
            AAE: aq_2068(argB)
            TMA: TM1784
            MJA: MJ0069(argB)
            MTH: MTH183
            AFU: AF1280(argB)
            PHO: PH1718
            PAB: PAB0292(argB)
            APE: APE1461
            SSO: SSO0156(argB)
            STO: ST0194
            SCE: YER069W(ARG5)
MOTIF       PS: PS01224  [LIVMA]-[GSA]-x-[PA]-G-C-[FYN]-[AVP]-T-[GSAC]-x(3)-
                         [GTAC]-[LIVMCA]-x-P
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.8
            ExPASy - ENZYME nomenclature database: 2.7.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.8
            BRENDA, the Enzyme Database: 2.7.2.8
///
ENTRY       EC 2.7.2.9
NAME        Transferred to EC 6.3.5.5
            Carbamoyl-phosphate synthase (glutamine-hydrolysing)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
COMMENT     Transferred entry. Now EC 6.3.5.5 - Carbamoyl-phosphate synthase
            (glutamine-hydrolysing).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.9
            ExPASy - ENZYME nomenclature database: 2.7.2.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.9
///
ENTRY       EC 2.7.2.10
NAME        Phosphoglycerate kinase (GTP)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     GTP:3-phospho-D-glycerate 1-phosphotransferase
REACTION    GTP + 3-Phospho-D-glycerate = GDP +
            3-Phospho-D-glyceroyl phosphate
SUBSTRATE   GTP
            3-Phospho-D-glycerate
PRODUCT     GDP
            3-Phospho-D-glyceroyl phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.10
            ExPASy - ENZYME nomenclature database: 2.7.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.10
            BRENDA, the Enzyme Database: 2.7.2.10
///
ENTRY       EC 2.7.2.11
NAME        Glutamate 5-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:L-glutamate 5-phosphotransferase
REACTION    ATP + L-Glutamate = ADP + L-Glutamate 5-phosphate
SUBSTRATE   ATP
            L-Glutamate
PRODUCT     ADP
            L-Glutamate 5-phosphate
COMMENT     Product rapidly cyclizes to 5-oxoproline and orthophosphate
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b0242(proB)
            ECE: Z0303(proB)
            ECS: ECs0269
            YPE: YPO3222(proB)
            HIN: HI0900(proB)
            PMU: PM1896(proB)
            XFA: XF1004
            VCH: VC2274
            PAE: PA4565(proB)
            NME: NMB1069
            NMA: NMA1268(proB)
            CJE: Cj0097(proB)
            MLO: mll4011 mlr6298
            SME: SMc03252(proB2) SMc03776(proB1)
            CCR: CC0314
            BSU: BG10963(proB) BG12658(proJ)
            BHA: BH1505
            LLA: L0117(proB)
            SPY: SPy1672(proB)
            SPN: SP0931
            SPR: spr0832(proB)
            CAC: CAC3253(proB)
            MTU: Rv2439c(proB)
            MTC: MT2515
            MLE: ML1464(proB)
            TPA: TP0351
            SYN: slr2035(proB)
            DRA: DR1827
            AAE: aq_1134(proB)
            TMA: TM0294
            SCE: YDR300C(PRO1)
            SPO: SPAC17H9.13C(spac17h9.13c)
            ATH: At2g39800(T5I7.10)
            CEL: T22H6.2
            DME: CG7470
            HSA: 5832(PYCS)
DISEASE     MIM: 138250  Pyrroline-5-carboxlate synthetase
MOTIF       PS: PS00902  [GSTN]-x(2)-G-x-G-[GC]-[IM]-x-[STA]-K-[LIVM]-x-[SA]-
                         [TCA]-x(2)-[GALV]
            PS: PS01223  V-x(5)-A-[LIV]-x-H-I-x(2)-[HY]-[GS]-[ST]-x-H-[ST]-[DE]-
                         x-I
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.11
            ExPASy - ENZYME nomenclature database: 2.7.2.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.11
            BRENDA, the Enzyme Database: 2.7.2.11
///
ENTRY       EC 2.7.2.12
NAME        Acetate kinase (pyrophosphate)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     Pyrophosphate:acetate phosphotransferase
REACTION    Pyrophosphate + Acetate = Orthophosphate + Acetyl phosphate
SUBSTRATE   Pyrophosphate
            Acetate
PRODUCT     Orthophosphate
            Acetyl phosphate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.12
            ExPASy - ENZYME nomenclature database: 2.7.2.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.12
            BRENDA, the Enzyme Database: 2.7.2.12
///
ENTRY       EC 2.7.2.13
NAME        Glutamate 1-kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:L-glutamate 1-phosphotransferase
REACTION    ATP + L-Glutamate = ADP + alpha-D-Glutamyl phosphate
SUBSTRATE   ATP
            L-Glutamate
PRODUCT     ADP
            alpha-D-Glutamyl phosphate
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.13
            ExPASy - ENZYME nomenclature database: 2.7.2.13
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.13
            BRENDA, the Enzyme Database: 2.7.2.13
///
ENTRY       EC 2.7.2.14
NAME        Branched-chain-fatty-acid kinase
            Isobutyrate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a carboxyl group as acceptor
SYSNAME     ATP:branched-chain-fatty-acid 1-phosphotransferase
REACTION    ATP + 2-Methylpropanoate = ADP + 2-Methylpropanoyl phosphate
SUBSTRATE   ATP
            2-Methylpropanoate
PRODUCT     ADP
            2-Methylpropanoyl phosphate
COMMENT     3-Methylbutanoate, 2-methylbutanoate, pentanoate, butanoate and
            propanoate can also act as acceptors (cf. EC 2.7.2.7).
MOTIF       PS: PS01075  [LIVFMA]-[LIVM]-x-[LIVMA]-N-x-G-S-[ST](2)-x-[KE]
            PS: PS01076  [LIVMATQ]-[LIVMA]-x(2)-H-x-G-x-G-x-[ST]-[LIVMA]-x-
                         [AVC]-x(3)-G
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.2.14
            ExPASy - ENZYME nomenclature database: 2.7.2.14
            WIT (What Is There) Metabolic Reconstruction: 2.7.2.14
            BRENDA, the Enzyme Database: 2.7.2.14
///
ENTRY       EC 2.7.3.1
NAME        Guanidoacetate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:guanidoacetate N-phosphotransferase
REACTION    ATP + Guanidinoacetate = ADP + Phosphoguanidinoacetate
SUBSTRATE   ATP
            Guanidinoacetate
PRODUCT     ADP
            Phosphoguanidinoacetate
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
MOTIF       PS: PS00112  C-P-x(0,1)-[ST]-N-[IL]-G-T
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.1
            ExPASy - ENZYME nomenclature database: 2.7.3.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.1
            BRENDA, the Enzyme Database: 2.7.3.1
///
ENTRY       EC 2.7.3.2
NAME        Creatine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:creatine N-phosphotransferase
REACTION    ATP + Creatine = ADP + Phosphocreatine
SUBSTRATE   ATP
            Creatine
            N-Ethylglycocyamine
PRODUCT     ADP
            Phosphocreatine
COMMENT     N-Ethylglycocyamine can also act as acceptor.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       MMU: 88407(Ckb) 99441(Ckmt1)
            HSA: 1152(CKB) 1156(CKBE) 1158(CKM) 1159(CKMT1) 1160(CKMT2)
DISEASE     MIM: 123280  Creatine kinase, brain type
            MIM: 123290  Creatine kinase, mitochondrial
            MIM: 123295  Creatine kinase, mitochondrial-2 (sarcomeric)
            MIM: 123310  Creatine kinase, muscle type
MOTIF       PS: PS00112  C-P-x(0,1)-[ST]-N-[IL]-G-T
STRUCTURES  PDB: 1CRK  1G0W  1QH4  1QK1  2CRK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.2
            ExPASy - ENZYME nomenclature database: 2.7.3.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.2
            BRENDA, the Enzyme Database: 2.7.3.2
            SCOP (Structural Classification of Proteins): 2.7.3.2
///
ENTRY       EC 2.7.3.3
NAME        Arginine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:L-arginine N-phosphotransferase
REACTION    ATP + L-Arginine = ADP + N-Phospho-L-arginine
SUBSTRATE   ATP
            L-Arginine
PRODUCT     ADP
            N-Phospho-L-arginine
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       CEL: F46H5.3 ZC434.8
            DME: CG5144 CG5173(Argk)
MOTIF       PS: PS00112  C-P-x(0,1)-[ST]-N-[IL]-G-T
STRUCTURES  PDB: 1BG0  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.3
            ExPASy - ENZYME nomenclature database: 2.7.3.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.3
            BRENDA, the Enzyme Database: 2.7.3.3
            SCOP (Structural Classification of Proteins): 2.7.3.3
///
ENTRY       EC 2.7.3.4
NAME        Taurocyamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:taurocyamine N-phosphotransferase
REACTION    ATP + Taurocyamine = ADP + N-Phosphotaurocyamine
SUBSTRATE   ATP
            Taurocyamine
PRODUCT     ADP
            N-Phosphotaurocyamine
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
MOTIF       PS: PS00112  C-P-x(0,1)-[ST]-N-[IL]-G-T
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.4
            ExPASy - ENZYME nomenclature database: 2.7.3.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.4
            BRENDA, the Enzyme Database: 2.7.3.4
///
ENTRY       EC 2.7.3.5
NAME        Lombricine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:lombricine N-phosphotransferase
REACTION    ATP + Lombricine = ADP + N-Phospholombricine
SUBSTRATE   ATP
            Lombricine
            Thalassemine
PRODUCT     ADP
            N-Phospholombricine
COMMENT     Also acts on methylated lombricines such as thalassemine;
            the specificity varies with the source species.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
MOTIF       PS: PS00112  C-P-x(0,1)-[ST]-N-[IL]-G-T
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.5
            ExPASy - ENZYME nomenclature database: 2.7.3.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.5
            BRENDA, the Enzyme Database: 2.7.3.5
///
ENTRY       EC 2.7.3.6
NAME        Hypotaurocyamine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:hypotaurocyamine N-phosphotransferase
REACTION    ATP + Hypotaurocyamine = ADP + N-Phosphohypotaurocyamine
SUBSTRATE   ATP
            Hypotaurocyamine
PRODUCT     ADP
            N-Phosphohypotaurocyamine
COMMENT     Also acts, more slowly, on taurocyamine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.6
            ExPASy - ENZYME nomenclature database: 2.7.3.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.6
            BRENDA, the Enzyme Database: 2.7.3.6
///
ENTRY       EC 2.7.3.7
NAME        Opheline kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:guanidinoethyyl-methyl-phosphate phosphotransferase
REACTION    ATP + Guanidinoethyl methyl phosphate = ADP +
            N-Phosphoguanidinoethyl methyl phosphate
SUBSTRATE   ATP
            Guanidinoethyl methyl phosphate
PRODUCT     ADP
            N-Phosphoguanidinoethyl methyl phosphate
COMMENT     Has a little activity on taurocyamine, lombricine and
            phosphotaurocyamine.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.7
            ExPASy - ENZYME nomenclature database: 2.7.3.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.7
            BRENDA, the Enzyme Database: 2.7.3.7
///
ENTRY       EC 2.7.3.8
NAME        Ammonia kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:ammonia phosphotransferase
REACTION    ATP + NH3 = ADP + Phosphoramide
SUBSTRATE   ATP
            NH3
PRODUCT     ADP
            Phosphoramide
COMMENT     Has a wide specificity.  In the reverse direction N-phosphoglycine
            and N-phosphohistidine can also act as phosphate donors, and ADP,
            dADP, GDP, CDP, dTDP, dCDP, IDP and UDP can act as phosphate
            acceptors (in decreasing order of activity).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.8
            ExPASy - ENZYME nomenclature database: 2.7.3.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.8
            BRENDA, the Enzyme Database: 2.7.3.8
///
ENTRY       EC 2.7.3.9
NAME        Phosphoenolpyruvate--protein phosphotransferase
            Enzyme I of the phosphotransferase system (cf. EC 2.7.1.69)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     Phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase
REACTION    Phosphoenolpyruvate + Protein histidine = Pyruvate +
            Protein N-pros-phosphohistidine
SUBSTRATE   Phosphoenolpyruvate
            Protein histidine
PRODUCT     Pyruvate
            Protein N-pros-phosphohistidine
COMMENT     Acts only on histidine residues in specific phosphocarrier
            proteins of low molecular mass (9.5 kDa) involved in bacterial
            sugar transport. A similar reaction, where the protein is the
            enzyme EC 2.7.9.2, is part of the mechanism of that enzyme.
            (EC 2.7.9.2 Pyruvate, water dikinase)
GENES       ECO: b2383 b2416(ptsI) b2829(ptsP) b3947(ptsA)
            ECE: Z3648 Z3682(ptsI) Z4146(ptsP) Z5502(ptsA)
            ECS: ECs3263 ECs3288 ECs3686 ECs4877
            YPE: YPO0405 YPO0785(ptsP) YPO2994(ptsI)
            HIN: HI1712(ptsI)
            PMU: PM0897(ptsI)
            XFA: XF1402
            VCH: VC0672 VC0965
            PAE: PA0337(ptsP) PA3562 PA3760
            BUC: BU064(ptsI)
            NME: NMB2044
            NMA: NMA0392(ptsI)
            MLO: mll3436 mll3609 mll5291
            SME: SMc02437(ptsP)
            CCR: CC0448 CC0488 CC0537 CC0849
            BSU: BG10201(ptsI)
            BHA: BH3073(ptsI)
            SAU: SA0935(ptsI)
            SAV: SAV1069(ptsI)
            LLA: L120628(ptsI)
            SPY: SPy1372(pstI)
            SPN: SP1176
            SPR: spr1062(ptsI)
            CAC: CAC3087
            MGE: MG429(ptsI)
            MPN: C12_orf572(ptsI)
            MPU: MYPU_6020(ptsI)
            CTR: CT336
            CMU: TC0613
            CPN: CPn0038
            CPA: CP0737
            CPJ: ptsI
            BBU: BB0558(ptsI)
MOTIF       PS: PS00369  G-[LIVM]-H-[STAV]-R-[PAS]-[GSTA]-[STAMVN]
            PS: PS00370  G-[GA]-x-[STN]-x-H-[STA]-[STAV]-[LIVM](2)-[STAV]-[RG]
            PS: PS00372  [DENQ]-x(6)-[LIVMF]-[GA]-x(2)-[LIVM]-A-[LIVM]-P-H-[GAC]
            PS: PS00589  [GSTADE]-[KREQSTIV]-x(4)-[KRDN]-S-[LIVMF](2)-x-[LIVM]-
                         x(2)-[LIVM]-[GADE]
            PS: PS00742  [DEQSK]-x-[LIVMF]-S-[LIVMF]-G-[ST]-N-D-[LIVM]-x-Q-
                         [LIVMFYGT]-[STALIV]-[LIVMFY]-[GAS]-x(2)-R
STRUCTURES  PDB: 1EZA  1EZB  1EZC  1EZD  1ZYM  2EZA  2EZB  2EZC  3EZA  3EZB  
                 3EZE  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.9
            ExPASy - ENZYME nomenclature database: 2.7.3.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.9
            BRENDA, the Enzyme Database: 2.7.3.9
            SCOP (Structural Classification of Proteins): 2.7.3.9
///
ENTRY       EC 2.7.3.10
NAME        Agmatine kinase
            Phosphagen phosphokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:agmatine N4-phosphotransferase
REACTION    ATP + Agmatine = ADP + N4-Phosphoagmatine
SUBSTRATE   ATP
            Agmatine
PRODUCT     ADP
            N4-Phosphoagmatine
COMMENT     L-Arginine can act as acceptor, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.10
            ExPASy - ENZYME nomenclature database: 2.7.3.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.10
            BRENDA, the Enzyme Database: 2.7.3.10
///
ENTRY       EC 2.7.3.11
NAME        Protein-histidine pros-kinase
            Protein kinase (histidine)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:protein-L-histidine N-pros-phosphotransferase
REACTION    ATP + Protein histidine = ADP +
            Protein N(pai)-phospho-L-histidine
SUBSTRATE   ATP
            Protein histidine
PRODUCT     ADP
            Protein N(pai)-phospho-L-histidine
COMMENT     A number of histones can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.11
            ExPASy - ENZYME nomenclature database: 2.7.3.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.11
            BRENDA, the Enzyme Database: 2.7.3.11
///
ENTRY       EC 2.7.3.12
NAME        Protein-histidine tele-kinase
            Protein kinase (histidine)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a nitrogenous group as acceptor
SYSNAME     ATP:protein-L-histidine N-tele-phosphotransferase
REACTION    ATP + Protein histidine = ADP +
            Protein N(tau)-phospho-L-histidine
SUBSTRATE   ATP
            Protein histidine
PRODUCT     ADP
            Protein N(tau)-phospho-L-histidine
COMMENT     A number of histones can act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.3.12
            ExPASy - ENZYME nomenclature database: 2.7.3.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.3.12
            BRENDA, the Enzyme Database: 2.7.3.12
///
ENTRY       EC 2.7.4.1
NAME        Polyphosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:polyphosphate phosphotransferase
REACTION    ATP + (Phosphate)n = ADP + (Phosphate)n+1
SUBSTRATE   ATP
            (Phosphate)n
PRODUCT     ADP
            (Phosphate)n+1
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
GENES       ECO: b2501(ppk)
            ECE: Z3764(ppk)
            ECS: ECs3363
            YPE: YPO2836(ppk)
            XFA: XF2591
            VCH: VC0723
            PAE: PA5242(ppk)
            NME: NMB1900
            NMA: NMA0555(ppk)
            HPY: HP1010(ppk)
            HPJ: jhp0413
            CJE: Cj1359(ppk)
            MLO: mlr8161
            SME: SMc00618(ppk)
            CCR: CC1710
            BHA: BH1392(ppk)
            CAC: CAC0622
            MTU: Rv2984(ppk)
            MTC: MT3062
            MLE: ML1681
            SYN: sll0290(ppk)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.1
            ExPASy - ENZYME nomenclature database: 2.7.4.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.1
            BRENDA, the Enzyme Database: 2.7.4.1
///
ENTRY       EC 2.7.4.2
NAME        Phosphomevalonate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:(R)-5-phosphomevalonate phosphotransferase
REACTION    ATP + (R)-5-Phosphomevalonate = ADP +
            (R)-5-Diphosphomevalonate
SUBSTRATE   ATP
            (R)-5-Phosphomevalonate
PRODUCT     ADP
            (R)-5-Diphosphomevalonate
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       SAU: SA0549(mvaK2)
            SAV: SAV0581
            LLA: L10014(yebA)
            SPY: SPy0878(mvaK2)
            SPN: SP0383
            SPR: spr0340(mvaK2)
            BBU: BB0687
            SSO: SSO2988
            STO: ST0978
            SCE: YMR220W(ERG8)
            SPO: SPAC343.01C(spac343.01c)
            ATH: At1g31910(F5M6.9)
            DME: CG10268
            HSA: 10654(PMVK)
MOTIF       PS: PS00627  [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-L-[GS]-S-S-[GSA]-[GSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.2
            ExPASy - ENZYME nomenclature database: 2.7.4.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.2
            BRENDA, the Enzyme Database: 2.7.4.2
///
ENTRY       EC 2.7.4.3
NAME        Adenylate kinase
            Myokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:AMP phosphotransferase
REACTION    ATP + AMP = ADP + ADP
SUBSTRATE   ATP
            Inorganic triphosphate
            AMP
PRODUCT     ADP
            Pyrophosphate
COMMENT     Inorganic triphosphate can also act as donor.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0474(adk)
            ECE: Z0591(adk)
            ECS: ECs0527
            YPE: YPO3118(adk)
            HIN: HI0349(adk)
            PMU: PM0284(adk)
            XFA: XF0275
            VCH: VC0986
            PAE: PA3686(adk)
            BUC: BU484(adk)
            NME: NMB0823
            NMA: NMA1032(adk)
            HPY: HP0618(adk)
            HPJ: jhp0561
            CJE: Cj0639c(adk)
            RPR: RP638(adk)
            RCO: RC0985(adk)
            MLO: mlr0322
            SME: SMc01288(adk)
            ATU: AGR_C_3521
            CCR: CC1269
            BSU: BG10446(adk)
            BHA: BH0155(adk)
            SAU: SA2027(adk)
            SAV: SAV2215(adk)
            LLA: L140714(adk)
            SPY: SPy0074(adk)
            SPN: SP0231
            SPR: spr0210(adk)
            CAC: CAC3112(adk)
            MGE: MG171(adk)
            MPN: GT9_orf215(adk)
            MPU: MYPU_5670(adk)
            UUR: UU251(adk)
            MTU: Rv0733(adk)
            MTC: MT0757
            MLE: ML1832(adk)
            CTR: CT128
            CMU: TC0404
            CPN: CPn0244
            CPA: CP0518
            CPJ: adk
            BBU: BB0417(adk)
            TPA: TP0595(adk)
            SYN: sll1059(adk) sll1815(adk)
            DRA: DR2117
            AAE: aq_078(kad)
            TMA: TM1479
            MJA: MJ0479(adk)
            MTH: MTH27
            AFU: AF0676(adk)
            HAL: VNG1724G(adk)
            TAC: Ta1247
            TVO: TVG0345885
            PHO: PH1117 PH1753
            PAB: PAB0739(adkE) PAB2140
            APE: APE0981
            SSO: SSO0694(adkA)
            STO: ST0410
            SCE: YDR226W(ADK1) YER170W(ADK2)
            SPO: ADK1(adk1)
            CEL: C29E4.8 F38B2.4 ZK673.2
            DME: CG17146 CG3140(anon-Dak2) CG6612
            MMU: 87977(Ak1) 87978(Ak2)
            HSA: 203(AK1) 204(AK2) 205(AK3) 26289(AK5)
DISEASE     MIM: 103000  Adenylate kinase-1
            MIM: 103020  Adenylate kinase-2, mitochondrial
MOTIF       PS: PS00113  [LIVMFYWCA]-[LIVMFYW](2)-D-G-[FYI]-P-R-x(3)-[NQ]
STRUCTURES  PDB: 4AKE  3AKY  3ADK  2ECK  2AKY  2AK2  1ZIP  1ZIO  1ZIN  1ZAK  
                 1NKS  1AK2  1AKE  1AKY  1ANK  1DVR  1E4V  1E4Y  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.3
            ExPASy - ENZYME nomenclature database: 2.7.4.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.3
            BRENDA, the Enzyme Database: 2.7.4.3
            SCOP (Structural Classification of Proteins): 2.7.4.3
///
ENTRY       EC 2.7.4.4
NAME        Nucleoside-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:nucleoside-phosphate phosphotransferase
REACTION    ATP + Nucleoside phosphate = ADP + Nucleoside diphosphate
SUBSTRATE   ATP
            Nucleoside phosphate
PRODUCT     ADP
            Nucleoside diphosphate
COMMENT     Many nucleotides can act as acceptors; other nucleoside
            triphosphates can act instead of ATP.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.4
            ExPASy - ENZYME nomenclature database: 2.7.4.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.4
            BRENDA, the Enzyme Database: 2.7.4.4
///
ENTRY       EC 2.7.4.5
NAME        Deleted entry
            Deoxycytidylate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
COMMENT     Deleted entry. Now included with EC 2.7.4.14.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.5
            ExPASy - ENZYME nomenclature database: 2.7.4.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.5
///
ENTRY       EC 2.7.4.6
NAME        Nucleoside-diphosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:nucleoside-diphosphate phosphatransferase
REACTION    ATP + Nucleoside diphosphate = ADP + Nucleoside triphosphate
SUBSTRATE   ATP
            Nucleoside diphosphate
            ADP
            GDP
            UDP
            IDP
            CDP
            XDP
            dATP
            GTP
            dGTP
            UTP
            dUTP
            ITP
            dITP
            CTP
            dCTP
            XTP
            dXTP
PRODUCT     ADP
            Nucleoside triphosphate
            dADP
            GDP
            dGDP
            UDP
            dUDP
            IDP
            dIDP
            CDP
            dCDP
            XDP
            dXDP
            ATP
            GTP
            UTP
            ITP
            CTP
            XTP
COMMENT     Many nucleoside diphosphate can act as acceptors, while many
            ribo- and deoxyribonucleoside triphosphate can act as donors.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2518(ndk)
            ECE: Z3781(ndk)
            ECS: ECs3380
            YPE: YPO2883(ndk)
            HIN: HI0876(ndk)
            PMU: PM1028(ndk)
            XFA: XF0458
            VCH: VC0756
            PAE: PA3807(ndk)
            NME: NMB1307
            NMA: NMA1521(ndk)
            HPY: HP0198(ndk)
            HPJ: jhp0184
            CJE: Cj0332c(ndk)
            RPR: RP055(ndk)
            RCO: RC0083(ndk)
            MLO: mll7917
            SME: SMc00595(ndk)
            CCR: CC1699
            BSU: BG10282(ndk)
            BHA: BH1654(ndk)
            SAU: SA1301(ndk)
            SAV: SAV1458(ndk)
            SPN: SP1959
            SPR: spr1775(ndk)
            MTU: Rv2445c(ndkA)
            MTC: MT2521
            MLE: ML1469(ndk)
            CTR: CT500
            CMU: TC0787
            CPN: CPn0619
            CPA: CP0128
            CPJ: ndk
            BBU: BB0463(ndk)
            TPA: TP1010
            SYN: sll1852(ndk)
            DRA: DR2499
            AAE: aq_1590(ndk)
            MJA: MJ1265(ndk)
            MTH: MTH258
            AFU: AF0767(ndk)
            HAL: VNG1160G(ndk)
            TAC: Ta1113
            TVO: TVG0438422
            PHO: PH0698
            PAB: PAB1489(ndk)
            APE: APE2377
            SSO: SSO0230(ndk)
            STO: ST0280
            SCE: YKL067W(YNK1)
            SPO: NDK1(ndk1)
            ATH: At4g09320(T30A10.80) At4g11010(F25I24.220)
            CEL: F25H2.5
            DME: CG2210(awd)
            HSA: 29922(NME7) 4830(NME1) 4831(NME2) 4832(NME3) 4833(NME4)
DISEASE     MIM: 156490  Non-metastatic cells 1, protein (NM23A) expressed in
            MIM: 156491  Non-metastatic cells 2, protein (NM23) expressed in
MOTIF       PS: PS00469  N-x(2)-H-[GA]-S-D-[GSA]-[LIVMPKNE]
STRUCTURES  PDB: 1BE4  1NDL  1EHW  1F3F  1NHK  2NCK  2BEF  1NUE  1NSQ  1NSP  
                 1NSK  1B4S  1B99  1NPK  1BHN  1BUX  1F6T  1HHQ  1HIY  1HLW  
                 1KDN  1LEO  1LWX  1NCL  1NDC  1NDK  1NLK  1NDP  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.6
            ExPASy - ENZYME nomenclature database: 2.7.4.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.6
            BRENDA, the Enzyme Database: 2.7.4.6
            SCOP (Structural Classification of Proteins): 2.7.4.6
///
ENTRY       EC 2.7.4.7
NAME        Phosphomethylpyrimidine kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
REACTION    ATP + 4-Amino-2-methyl-5-phosphomethylpyrimidine = ADP +
            4-Amino-2-methyl-5-diphosphomethylpyrimidine
SUBSTRATE   ATP
            4-Amino-2-methyl-5-phosphomethylpyrimidine
PRODUCT     ADP
            4-Amino-2-methyl-5-diphosphomethylpyrimidine
PATHWAY     PATH: MAP00730  Thiamine metabolism
GENES       ECO: b2103(thiD)
            ECE: Z3267(thiD)
            ECS: ECs2906
            YPE: YPO2859(thiD)
            HIN: HI0416(thid)
            PMU: PM1261(thiD)
            XFA: XF0621
            VCH: VC1296
            PAE: PA3975(thiD)
            NME: NMB1616
            NMA: NMA1815(thiD)
            HPY: HP0844(thi)
            HPJ: jhp0782
            CJE: Cj1082c(thiD)
            MLO: mll5788
            SME: SMb20962(thiD)
            CCR: CC3223
            BSU: BG10598(thiD) BG13151(yjbV)
            BHA: BH1435
            SAU: SA0537 SA1896(thiD)
            SAV: SAV0569 SAV2078(thiD)
            LLA: L0200(thiD1) L0202(thiD2)
            SPY: SPy1900(thiD)
            SPN: SP0726 SP1598
            SPR: spr0638(thiD)
            CAC: CAC3095(thiK)
            MTU: Rv0422c(thiD)
            MTC: MT0436
            MLE: ML0295(thiD)
            TPA: TP0115
            DRA: DRA0171
            AAE: aq_1960(thiD)
            MJA: MJ0236
            AFU: AF2208(thiD)
            HAL: VNG2606G(thiD)
            TAC: Ta1281
            TVO: TVG0501372
            PHO: PH1155
            PAB: PAB1646(thiD)
            APE: APE2400
            SSO: SSO0002(thiD-1) SSO2393(thiD-2)
            STO: ST0526
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.7
            ExPASy - ENZYME nomenclature database: 2.7.4.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.7
            BRENDA, the Enzyme Database: 2.7.4.7
///
ENTRY       EC 2.7.4.8
NAME        Guanylate kinase
            Deoxyguanylate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:(d)GMP phosphotransferase
REACTION    ATP + GMP = ADP + GDP
SUBSTRATE   ATP
            GMP
            dGMP
            dATP
PRODUCT     ADP
            GDP
            dGDP
            dADP
COMMENT     dGMP can also act as acceptor, and dATP can act as donor.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3648(gmk)
            ECE: Z5074(gmk)
            ECS: ECs4523
            YPE: YPO0040(gmk)
            HIN: HI1743(gmk)
            PMU: PM0922(gmk)
            XFA: XF1503
            VCH: VC2708
            PAE: PA5336(gmk)
            BUC: BU434(gmk)
            NME: NMB1661
            NMA: NMA1919(gmk)
            HPY: HP0321(gmk)
            HPJ: jhp0304
            CJE: Cj1177c(gmk)
            RPR: RP765(gmk)
            RCO: RC1194(gmk)
            MLO: mlr7857
            SME: SMb21170 SMc00577(gmk)
            CCR: CC1681
            BSU: BG13386(gmk)
            BHA: BH2512(gmk)
            SAU: SA1052(gmk)
            SAV: SAV1196(gmk)
            LLA: L149828(gmk)
            SPY: SPy1632(gmk)
            SPN: SP1738
            SPR: spr1583(gmk)
            CAC: CAC1718
            MGE: MG107(gmk)
            MPN: K04_orf239(gmk)
            MPU: MYPU_6870(gmk)
            UUR: UU213(gmk)
            MTU: Rv1389(gmk)
            MTC: MT1434
            MLE: ML0541(gmk)
            CTR: CT030
            CMU: TC0299
            CPN: CPn0120
            CPA: CP0653
            CPJ: gmk
            SYN: slr1123(gmk)
            DRA: DR2289
            AAE: aq_184
            TMA: TM1689
            SCE: YDR454C(GUK1)
            SPO: SPBC1198.05(spbc1198.05)
            CEL: T03F1.8
            DME: CG11811 CG1725(dlg1)
            HSA: 2987(GUK1) 2988(GUK2)
MOTIF       PS: PS00856  T-[ST]-R-x(2)-[KR]-x(2)-[DE]-x(2)-G-x(2)-Y-x-[FY]-
                         [LIVMK]
            PS: PS50052  Guanylate kinase domain profile
STRUCTURES  PDB: 1EX7  1GKY  1EX6  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.8
            ExPASy - ENZYME nomenclature database: 2.7.4.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.8
            BRENDA, the Enzyme Database: 2.7.4.8
            SCOP (Structural Classification of Proteins): 2.7.4.8
///
ENTRY       EC 2.7.4.9
NAME        dTMP kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:dTMP phosphotransferase
REACTION    ATP + dTMP = ADP + dTDP
SUBSTRATE   ATP
            dTMP
PRODUCT     ADP
            dTDP
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b1098(tmk)
            ECE: Z1737(tmk)
            ECS: ECs1476
            YPE: YPO1605(tmk)
            HIN: HI0456(tmk)
            PMU: PM1673
            XFA: XF0580
            VCH: VC2016
            PAE: PA2962(tmk)
            BUC: BU353(tmk)
            NME: NMB0670
            NMA: NMA0869(tmk)
            HPY: HP1474(tmk)
            HPJ: jhp1367
            CJE: Cj0766c(tmk)
            RPR: RP684(tmk)
            RCO: RC1047(tmk)
            MLO: mll0424
            SME: SMc01189(tmk)
            CCR: CC1824
            BSU: BG10092(tmk)
            BHA: BH0042(tmk)
            SAU: SA0440(tmk)
            SAV: SAV0469(tmk)
            LLA: L3846(yeaB)
            SPY: SPy0399(tmk)
            SPN: SP0935
            SPR: spr0835(tmk)
            MGE: MG006(tmk)
            MPN: D12_orf210
            MPU: MYPU_0520(tmk)
            UUR: UU020(tmk)
            MTU: Rv3247c(tmk)
            MTC: MT3345
            MLE: ML0772(tmk)
            CTR: CT188
            CMU: TC0460
            CPN: CPn0273
            CPA: CP0486
            CPJ: tdk
            BBU: BB0793(tmk)
            TPA: TP0354
            SYN: slr0379(tmk)
            DRA: DR0111
            AAE: aq_969(tmk)
            TMA: TM1099
            MJA: MJ0293
            MTH: MTH1100 MTH1765
            AFU: AF0061(tmk) AF1308
            HAL: VNG1929G(tmk)
            TAC: Ta0081
            TVO: TVG0181531
            PHO: PH1695
            PAB: PAB0319(tmk)
            APE: APE2090
            SSO: SSO0780(tmK-1) SSO1191 SSO1192(tmK-2)
            STO: ST0462
            SCE: YJR057W(CDC8)
            SPO: TMP(tmp) TMP1(tmp1)
            CEL: R53.2
            DME: CG5757
            HSA: 1841(DTYMK)
MOTIF       PS: PS01331  [LIV]-[LIVMGSTC]-[DET]-[RH]-[FYHCS]-x(2)-S-[GSTNP]-x-
                         [AVC]-[FY]-[STANQ]
STRUCTURES  PDB: 1E98  1E2E  1E2F  4TMK  3TMK  2TMK  1TMK  1E9B  1E9A  1E99  
                 1E2D  5TMP  1E2G  1E2Q  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.9
            ExPASy - ENZYME nomenclature database: 2.7.4.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.9
            BRENDA, the Enzyme Database: 2.7.4.9
            SCOP (Structural Classification of Proteins): 2.7.4.9
///
ENTRY       EC 2.7.4.10
NAME        Nucleoside-triphosphate--adenylate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     Nucleoside-triphosphate:AMP phosphotransferase
REACTION    Nucleoside triphosphate + AMP = Nucleoside diphosphate + ADP
SUBSTRATE   Nucleoside triphosphate
            AMP
PRODUCT     Nucleoside diphosphate
            ADP
COMMENT     Many nucleoside triphosphate can act as donors.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       HSA: 50808(AKL3L)
DISEASE     MIM: 103030  Adenylate kinase-3, mitochondrial
MOTIF       PS: PS00113  [LIVMFYWCA]-[LIVMFYW](2)-D-G-[FYI]-P-R-x(3)-[NQ]
STRUCTURES  PDB: 2AK3  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.10
            ExPASy - ENZYME nomenclature database: 2.7.4.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.10
            BRENDA, the Enzyme Database: 2.7.4.10
            SCOP (Structural Classification of Proteins): 2.7.4.10
///
ENTRY       EC 2.7.4.11
NAME        (Deoxy)adenylate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:(d)NMP phosphotransferase
REACTION    ATP + dAMP = ADP + dADP
SUBSTRATE   ATP
            dAMP
PRODUCT     ADP
            dADP
COMMENT     AMP can also act as acceptor.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.11
            ExPASy - ENZYME nomenclature database: 2.7.4.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.11
            BRENDA, the Enzyme Database: 2.7.4.11
///
ENTRY       EC 2.7.4.12
NAME        T2-induced deoxynucleotide kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:(d)NMP phosphotransferase
REACTION    ATP + dGMP or dTMP = ADP + dGDP or dTDP
SUBSTRATE   ATP
            dGMP
            dTMP
PRODUCT     ADP
            dGDP
            dTDP
COMMENT     dTMP and dAMP can act as acceptors; dATP can act as donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.12
            ExPASy - ENZYME nomenclature database: 2.7.4.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.12
            BRENDA, the Enzyme Database: 2.7.4.12
///
ENTRY       EC 2.7.4.13
NAME        (Deoxy)nucleoside-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:deoxynucleoside-phosphate phosphotransferase
REACTION    ATP + Deoxynucleoside phosphate = ADP +
            Deoxynucleoside diphosphate
SUBSTRATE   ATP
            Deoxynucleoside phosphate
            dATP
PRODUCT     ADP
            Deoxynucleoside diphosphate
            dADP
COMMENT     dATP can substitute for ATP.
STRUCTURES  PDB: 1DEK  1DEL  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.13
            ExPASy - ENZYME nomenclature database: 2.7.4.13
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.13
            BRENDA, the Enzyme Database: 2.7.4.13
            SCOP (Structural Classification of Proteins): 2.7.4.13
///
ENTRY       EC 2.7.4.14
NAME        Cytidylate kinase
            Deoxycytidylate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:CMP phosphotransferas
REACTION    ATP + CMP or dCMP = ADP + CDP or dCDP
SUBSTRATE   ATP
            CMP
            dCMP
PRODUCT     ADP
            CDP
            dCDP
COMMENT     UMP and dCMP can also act as acceptors.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b0910(cmk)
            ECE: Z1256(cmk)
            ECS: ECs0993
            YPE: YPO1391(cmk)
            HIN: HI1219(cmkA) HI1646(cmkB)
            PMU: PM0802(cmkA)
            XFA: XF2439
            VCH: VC1916
            PAE: PA3163(cmk)
            NME: NMB1300
            NMA: NMA1514(cmk)
            RPR: RP522(cmk)
            RCO: RC0748(cmk)
            MLO: mll5212
            SME: SMc00334(cmk)
            CCR: CC3588
            BSU: BG11004(cmk)
            BHA: BH1634(cmk)
            SAU: SA1309(cmk)
            SAV: SAV1467(cmk)
            LLA: L143791(cmk)
            SPY: SPy0803(cmk)
            SPN: SP1603
            SPR: spr1456(cmk)
            CAC: CAC1848(cmk)
            MGE: MG330(cmk)
            MPN: P01_orf217(cmk)
            MPU: MYPU_0890(cmk)
            UUR: UU342(cmk)
            MTU: Rv1712(cmk)
            MTC: MT1752
            MLE: ML1371(cmk)
            CTR: CT452
            CMU: TC0737
            CPN: CPn0568
            CPA: CP0181
            CPJ: cmk
            BBU: BB0128(cmk-1) BB0819(cmk-2)
            TPA: TP0342
            SYN: sll1249(panC)
            DRA: DR2543
            AAE: aq_2153(cmk)
            TMA: TM1443
            MJA: MJ0656(cmk)
            MTH: MTH30
            AFU: AF1900(cmk)
            HAL: VNG1727G(cmk)
            TAC: Ta1245
            TVO: TVG0347128
            PHO: PH1265
            PAB: PAB0763(cmk)
            APE: APE0978
            SSO: SSO0692(cmK)
            STO: ST0408
            HSA: 51727(LOC51727)
MOTIF       PS: PS00113  [LIVMFYWCA]-[LIVMFYW](2)-D-G-[FYI]-P-R-x(3)-[NQ]
STRUCTURES  PDB: 4UKD  3UKD  2UKD  2CMK  1UKE  1QF9  1CKE  5UKD  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.14
            ExPASy - ENZYME nomenclature database: 2.7.4.14
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.14
            BRENDA, the Enzyme Database: 2.7.4.14
            SCOP (Structural Classification of Proteins): 2.7.4.14
///
ENTRY       EC 2.7.4.15
NAME        Thiamin-diphosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:thiamin-diphosphate phosphotransferase
REACTION    ATP + Thiamine diphosphate = ADP + Thiamine triphosphate
SUBSTRATE   ATP
            Thiamine diphosphate
PRODUCT     ADP
            Thiamine triphosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.15
            ExPASy - ENZYME nomenclature database: 2.7.4.15
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.15
            BRENDA, the Enzyme Database: 2.7.4.15
///
ENTRY       EC 2.7.4.16
NAME        Thiamin-phosphate kinase
            Thiamin-monophosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:thiamin-phosphate phosphotransferase
REACTION    ATP + Thiamine monophosphate = ADP + Thiamine diphosphate
SUBSTRATE   ATP
            Thiamine monophosphate
PRODUCT     ADP
            Thiamine diphosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
GENES       ECO: b0417(thiL)
            ECE: Z0519(thiL)
            ECS: ECs0470
            YPE: YPO3180(thiL)
            HIN: HI1305(thil)
            PMU: PM0729(thiL)
            XFA: XF0956
            VCH: VC2266
            PAE: PA4051(thiL)
            NME: NMB0385
            NMA: NMA2103(thiL)
            CJE: Cj1458c(thiL)
            CCR: CC1361
            BSU: BG10693(thiL)
            BHA: BH0544
            MTU: Rv2977c(thiL)
            MTC: MT3055
            MLE: ML1676(thiL)
            SYN: slr1787
            AAE: aq_2119(thiL)
            MJA: MJ0028
            AFU: AF0733(thiL)
            HAL: VNG2011G(thiL)
            TAC: Ta0526
            TVO: TVG1054535
            PHO: PH1833
            PAB: PAB2358(thiL)
            APE: APE0235
            SSO: SSO0237(thiL)
            STO: ST0287
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.16
            ExPASy - ENZYME nomenclature database: 2.7.4.16
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.16
            BRENDA, the Enzyme Database: 2.7.4.16
///
ENTRY       EC 2.7.4.17
NAME        3-Phosphoglyceroyl-phosphate--polyphosphate phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     3-Phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase
REACTION    3-Phospho-D-glyceroyl phosphate + (Phosphate)n =
            3-Phosphoglycerate + (Phosphate)n+1
SUBSTRATE   3-Phospho-D-glyceroyl phosphate
            (Phosphate)n
PRODUCT     3-Phosphoglycerate
            (Phosphate)n+1
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.17
            ExPASy - ENZYME nomenclature database: 2.7.4.17
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.17
            BRENDA, the Enzyme Database: 2.7.4.17
///
ENTRY       EC 2.7.4.18
NAME        Farnesyl-diphosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:farnesyl-diphosphate phosphotransferase
REACTION    ATP + Farnesyl diphosphate = ADP + Farnesyl triphosphate
SUBSTRATE   ATP
            Farnesyl diphosphate
PRODUCT     ADP
            Farnesyl triphosphate
COMMENT     ADP can also act as donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.18
            ExPASy - ENZYME nomenclature database: 2.7.4.18
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.18
            BRENDA, the Enzyme Database: 2.7.4.18
///
ENTRY       EC 2.7.4.19
NAME        5-Methyldeoxycytidine-5'-phosphate kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase
REACTION    ATP + 5-Methyldeoxycytidine 5'-phosphate = ADP +
            5-Methyldeoxycytidine diphosphate
SUBSTRATE   ATP
            5-Methyldeoxycytidine 5'-phosphate
PRODUCT     ADP
            5-Methyldeoxycytidine diphosphate
COMMENT     The enzyme, from phage XP-12-infected Xanthomonas oryzae,
            converts m5dCMP into m5dCDP and then into m5dCTP.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.19
            ExPASy - ENZYME nomenclature database: 2.7.4.19
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.19
            BRENDA, the Enzyme Database: 2.7.4.19
///
ENTRY       EC 2.7.4.20
NAME        Dolichyl-diphosphate--polyphosphate phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with a phosphate group as acceptor
SYSNAME     Dolichyl-diphosphate:polyphosphate phosphotransferase
REACTION    Dolichyl diphosphate + (Phosphate)n = Dolichyl phosphate +
            (Phosphate)n+1
SUBSTRATE   Dolichyl diphosphate
            (Phosphate)n
PRODUCT     Dolichyl phosphate
            (Phosphate)n+1
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.4.20
            ExPASy - ENZYME nomenclature database: 2.7.4.20
            WIT (What Is There) Metabolic Reconstruction: 2.7.4.20
            BRENDA, the Enzyme Database: 2.7.4.20
///
ENTRY       EC 2.7.5.1
NAME        Transferred to EC 5.4.2.2
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.2 - Phosphoglucomutase.
STRUCTURES  PDB: 1C47  1C4G  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.1
            ExPASy - ENZYME nomenclature database: 2.7.5.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.1
            SCOP (Structural Classification of Proteins): 2.7.5.1
///
ENTRY       EC 2.7.5.2
NAME        Transferred to EC 5.4.2.3
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.3 - Phosphoacetylglucosamine
            mutase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.2
            ExPASy - ENZYME nomenclature database: 2.7.5.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.2
///
ENTRY       EC 2.7.5.3
NAME        Transferred to EC 5.4.2.1
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.1 - Phosphoglyceromutase.
STRUCTURES  PDB: 3PGM  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.3
            ExPASy - ENZYME nomenclature database: 2.7.5.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.3
            SCOP (Structural Classification of Proteins): 2.7.5.3
///
ENTRY       EC 2.7.5.4
NAME        Transferred to EC 5.4.2.4
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.4 - Bisphosphoglyceromutase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.4
            ExPASy - ENZYME nomenclature database: 2.7.5.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.4
///
ENTRY       EC 2.7.5.5
NAME        Transferred to EC 5.4.2.5
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.5 - Phosphoglucomutase
            (glucose-cofactor).
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.5
            ExPASy - ENZYME nomenclature database: 2.7.5.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.5
///
ENTRY       EC 2.7.5.6
NAME        Transferred to EC 5.4.2.7
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.7 - Phosphopentomutase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.6
            ExPASy - ENZYME nomenclature database: 2.7.5.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.6
///
ENTRY       EC 2.7.5.7
NAME        Transferred to EC 5.4.2.8
CLASS       Transferases
            Transferring phosphorus-containing groups
COMMENT     Transferred entry. Now EC 5.4.2.8 - Phosphomannomutase.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.5.7
            ExPASy - ENZYME nomenclature database: 2.7.5.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.5.7
///
ENTRY       EC 2.7.6.1
NAME        Ribose-phosphate pyrophosphokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:D-ribose-5-phosphate pyrophosphotransferase
REACTION    ATP + D-Ribose 5-phosphate = AMP +
            5-Phospho-alpha-D-ribose 1-diphosphate
SUBSTRATE   ATP
            dATP
            D-Ribose 5-phosphate
PRODUCT     AMP
            dAMP
            5-Phospho-alpha-D-ribose 1-diphosphate
COMMENT     dATP can also act as donor
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00230  Purine metabolism
GENES       ECO: b1207(prsA)
            ECE: Z1978(prsA)
            ECS: ECs1712
            YPE: YPO2013(prsA)
            HIN: HI1609(prsA)
            PMU: PM0244(prsA)
            XFA: XF2644
            VCH: VC2183
            PAE: PA4670(prs)
            BUC: BU169(prsA)
            NME: NMB0875
            NMA: NMA1093(prsA)
            HPY: HP0742(prsA)
            HPJ: jhp0679
            CJE: Cj0918c(prsA)
            MLO: mlr2685
            SME: SMc02686(prsA)
            CCR: CC0487
            BSU: BG10114(prs)
            BHA: BH0066(prs)
            SAU: SA0458(prs)
            SAV: SAV0488(prs)
            LLA: L109335(prsB) L25614(prsA)
            SPY: SPy0020(prsA.2) SPy1123(prs)
            SPN: SP0027 SP1095
            SPR: spr0028(prsA) spr1002(prs)
            CAC: CAC0819 CAC3221(prs)
            MGE: MG058(prsa)
            MPN: D09_orf388(prs)
            MPU: MYPU_1270(prs)
            UUR: UU193(prsA)
            MTU: Rv1017c(prsA)
            MTC: MT1045
            MLE: ML0248(prsA)
            BBU: BB0544(prs)
            TPA: TP0294
            SYN: sll0469(prsA)
            DRA: DR1456
            AAE: aq_1636(prs)
            TMA: TM1628
            MJA: MJ1366(prsA)
            MTH: MTH784
            AFU: AF0589(prsA-1) AF1419(prsA-2)
            HAL: VNG2203G(prsA)
            TAC: Ta0119
            TVO: TVG0201915
            PHO: PH1923
            PAB: PAB1114(prsA)
            APE: APE1834
            SSO: SSO1045
            STO: ST0946
            SCE: YBL068W(PRS4) YER099C(PRS2) YHL011C(PRS3) YKL181W(PRS1)
            SPO: PRS1(prs1) SPCC1620.06C(spcc1620.06c)
            ATH: At2g35390(T32F12.23)
            CEL: R151.2 W04G3.5
            DME: CG6767 CG6767_1
            HSA: 5631(PRPS1) 5634(PRPS2)
DISEASE     MIM: 311850  Phosphoribosyl pyrophosphate synthetase-1
            MIM: 311860  Phosphoribosyl pyrophosphate synthetase-2
MOTIF       PS: PS00114  D-[LI]-H-[SA]-x-Q-[IMST]-[QM]-G-[FY]-F-x(2)-P-[LIVMFC]-
                         D
STRUCTURES  PDB: 1DKR  1DKU  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.6.1
            ExPASy - ENZYME nomenclature database: 2.7.6.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.1
            BRENDA, the Enzyme Database: 2.7.6.1
            SCOP (Structural Classification of Proteins): 2.7.6.1
///
ENTRY       EC 2.7.6.2
NAME        Thiamin pyrophosphokinase
            Thiamin kinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:thiamin pyrophosphotransferase
REACTION    ATP + Thiamine = AMP + Thiamine diphosphate
SUBSTRATE   ATP
            Thiamine
PRODUCT     AMP
            Thiamine diphosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
GENES       SCE: YOR143C(THI80)
            SPO: TNR3(tnr3)
STRUCTURES  PDB: 1IG0  1IG3  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.6.2
            ExPASy - ENZYME nomenclature database: 2.7.6.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.2
            BRENDA, the Enzyme Database: 2.7.6.2
///
ENTRY       EC 2.7.6.3
NAME        2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyro-
            $phosphokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
            6'-pyrophosphotransferase
REACTION    ATP + 2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine =
            AMP + 2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)
            $pteridine
SUBSTRATE   ATP
            2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
PRODUCT     AMP
            2-Amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b0142(folK)
            ECE: Z0153(folK)
            ECS: ECs0146
            YPE: YPO3400(folK)
            HIN: HI0064(folK)
            PMU: PM0865(folK)
            XFA: XF0228
            VCH: VC0593
            PAE: PA4728(folK)
            NME: NMB0745
            NMA: NMA0958(folK)
            HPY: HP1036(folK)
            HPJ: jhp0388
            CJE: Cj0065c(folK)
            MLO: mll0786
            SME: SMc00465(folK)
            CCR: CC1551
            BSU: BG10142(folK)
            BHA: BH0095(folK)
            SAU: SA0474(folK)
            SAV: SAV0506
            LLA: L0175(folE)
            SPY: SPy1100(folK)
            SPN: SP0292
            SPR: spr0269(sulD)
            CAC: CAC2927(folA/folK)
            MTU: Rv3606c(folK)
            MTC: MT3711
            MLE: ML0226(folK)
            CTR: CT613
            CMU: TC0903
            CPN: CPn0758
            CPA: CP1114
            CPJ: folP
            SYN: slr1093(folK)
            DRA: DR0170
            AAE: aq_162(folK)
            TMA: TM0041
            SCE: YNL256W(FOL1)
MOTIF       PS: PS00792  [LIVM]-x-[AG]-[LIVMF](2)-N-x-T-x-D-S-F-x-D-x-[SG]
            PS: PS00793  [GE]-[SA]-x-[LIVM](2)-D-[LIVM]-G-[GP]-x(2)-[STA]-x-P
            PS: PS00794  [KRHD]-x-[GA]-[PSAE]-R-x(2)-D-[LIV]-D-[LIVM](2)
STRUCTURES  PDB: 1DY3  1EQM  1EQO  1EX8  1HKA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.6.3
            ExPASy - ENZYME nomenclature database: 2.7.6.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.3
            BRENDA, the Enzyme Database: 2.7.6.3
            SCOP (Structural Classification of Proteins): 2.7.6.3
///
ENTRY       EC 2.7.6.4
NAME        Nucleotide pyrophosphokinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:nucleoside-5'-phosphate pyrophosphotransferase
REACTION    ATP + Nucleoside 5'-phosphate = AMP +
            5'-Phosphonucleoside 3'-diphosphate
SUBSTRATE   ATP
            Nucleoside 5'-phosphate
PRODUCT     AMP
            5'-Phosphonucleoside 3'-diphosphate
COMMENT     The enzyme acts on the 5'-mono-, di- and triphosphate
            derivatives of purine nucleosides.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.6.4
            ExPASy - ENZYME nomenclature database: 2.7.6.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.4
            BRENDA, the Enzyme Database: 2.7.6.4
///
ENTRY       EC 2.7.6.5
NAME        GTP pyrophosphokinase
            Stringent factor
            Guanosine 3',5'-polyphosphate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Diphosphotransferases
SYSNAME     ATP:GTP 3'-pyrophosphotransferase
REACTION    ATP + GTP = AMP + Guanosine 3'-diphosphate 5'-triphosphate
SUBSTRATE   ATP
            GTP
            GDP
PRODUCT     AMP
            Guanosine 3'-diphosphate 5'-triphosphate
            Guanosine 3',5'-bis(diphosphate)
COMMENT     GDP can also act as acceptor
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2784(relA)
            ECE: Z4099(relA)
            ECS: ECs3644
            YPE: YPO3380(relA)
            HIN: HI0334(relA)
            PMU: PM1865(relA)
            XFA: XF1316
            VCH: VC2451
            PAE: PA0934(relA)
            NME: NMB1735
            NMA: NMA1991(relA)
            MLO: mlr7755
            SME: SMc02659(relA)
            BSU: BG12665(relA)
            BHA: BH1242(relA)
            SAU: SA1460(relA)
            SAV: SAV1621(relA)
            LLA: L0213(relA)
            SPY: SPy1981(relA)
            SPN: SP1645
            SPR: spr1487(relA)
            CAC: CAC2274(spoT)
            MTU: Rv2583c(relA)
            MTC: MT2660
            MLE: ML0491(relA)
            DRA: DR1838
            TMA: TM0729
STRUCTURES  PDB: 1E3H  1E3P  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.6.5
            ExPASy - ENZYME nomenclature database: 2.7.6.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.6.5
            BRENDA, the Enzyme Database: 2.7.6.5
///
ENTRY       EC 2.7.7.1
NAME        Nicotinamide-nucleotide adenylyltransferase
            NAD+ pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:nicotinamide-nucleotide adenylyltransferase
REACTION    ATP + Nicotinamide D-ribonucleotide = Pyrophosphate + NAD+
SUBSTRATE   ATP
            Nicotinamide D-ribonucleotide
            Nicotinate D-ribonucleotide
PRODUCT     Pyrophosphate
            NAD+
COMMENT     Nicotinate nucleotide can also act as acceptor. See also
            EC 2.7.7.18.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       MJA: MJ0541
            MTH: MTH150
            AFU: AF2315
            HAL: VNG0301C
            TAC: Ta0774
            TVO: TVG0879099
            PHO: PH0464
            PAB: PAB1318
            APE: APE0513
            SSO: SSO0255
            STO: ST0302
STRUCTURES  PDB: 1EJ2  1HYB  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.1
            ExPASy - ENZYME nomenclature database: 2.7.7.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.1
            BRENDA, the Enzyme Database: 2.7.7.1
///
ENTRY       EC 2.7.7.2
NAME        FMN adenylyltransferase
            FAD pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:FMN adenylyltransferase
REACTION    ATP + FMN = Pyrophosphate + FAD
SUBSTRATE   ATP
            FMN
PRODUCT     Pyrophosphate
            FAD
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0025(ribF)
            ECE: Z0029(ribF)
            ECS: ECs0028
            YPE: YPO0474(ribF)
            HIN: HI0963(ribF)
            PMU: PM1661(ribF)
            XFA: XF2419
            VCH: VC0681
            PAE: PA4561(ribF)
            BUC: BU150(ribF)
            NME: NMB1834
            NMA: NMA0621(ribF)
            HPY: HP1087(ribC)
            HPJ: jhp0338
            CJE: Cj0589(ribF)
            MLO: mlr8243
            SME: SMc00909(ribF)
            ATU: AGR_C_1228
            CCR: CC0703
            BSU: BG11495(ribC)
            BHA: BH2409(ribC)
            SAU: SA1115(ribC)
            SAV: SAV1260(ribC)
            LLA: L0167(ribC)
            SPY: SPy1250(mreA)
            SPN: SP1110
            SPR: spr1017(mreA)
            CAC: CAC1806
            MGE: MG145(ribf)
            MPN: VXpSPT7_orf269(yaaC)
            MPU: MYPU_5480(ribF)
            UUR: UU355(ribF)
            MTU: Rv2786c(ribF)
            MTC: MT2856
            MLE: ML0852(ribF)
            CTR: CT093
            CMU: TC0368
            CPN: CPn0320
            CPA: CP0437
            CPJ: ribF
            TPA: TP0888
            SYN: slr1882(ribF)
            DRA: DR1008
            AAE: aq_139(ribF)
            TMA: TM0857
            SCE: YDL045C(FAD1)
            SPO: SPCC1235.04C(spcc1235.04c)
            DME: CG16848 CG4407
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.2
            ExPASy - ENZYME nomenclature database: 2.7.7.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.2
            BRENDA, the Enzyme Database: 2.7.7.2
///
ENTRY       EC 2.7.7.3
NAME        Pantetheine-phosphate adenylyltransferase
            Dephospho-CoA pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:pantetheine-4'-phosphate adenylyltransferase
REACTION    ATP + Pantetheine 4'-phosphate = Pyrophosphate + Dephospho-CoA
SUBSTRATE   ATP
            Pantetheine 4'-phosphate
PRODUCT     Pyrophosphate
            Dephospho-CoA
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b3634(kdtB)
            ECE: Z5058(kdtB)
            ECS: ECs4509
            YPE: YPO0053(coaD)
            HIN: HI0651(kdtB)
            PMU: PM1304(kdtB)
            XFA: XF0980
            VCH: VC0222(KdtB)
            PAE: PA0363(coaD)
            BUC: BU583(kdtB)
            NME: NMB2019
            NMA: NMA0421(kdtB)
            HPY: HP1475(kdtB)
            HPJ: jhp1368
            CJE: Cj0767c(kdtB)
            MLO: mll0730
            SME: SMc01209(coaD)
            CCR: CC1581
            BSU: BG13361(coaD)
            BHA: BH2589(kdtB)
            SAU: SA0973
            SAV: SAV1107
            LLA: L21952(kdtB)
            SPY: SPy1537(kdtB)
            SPN: SP1968
            CAC: CAC1738(kdtB)
            MPU: MYPU_0970(kdtB)
            MTU: Rv2965c
            MTC: MT3043
            MLE: ML1663(coaD)
            BBU: BB0702(kdtB)
            TPA: TP0283
            SYN: slr0847(kdtB)
            DRA: DR0642
            AAE: aq_253(kdtB)
            TMA: TM0741
STRUCTURES  PDB: 1B6T  1QJC  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.3
            ExPASy - ENZYME nomenclature database: 2.7.7.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.3
            BRENDA, the Enzyme Database: 2.7.7.3
            SCOP (Structural Classification of Proteins): 2.7.7.3
///
ENTRY       EC 2.7.7.4
NAME        Sulfate adenylyltransferase
            ATP-sulfurylase
            Sulfurylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:sulfate adenylyltransferase
REACTION    ATP + Sulfate = Pyrophosphate + Adenylylsulfate
SUBSTRATE   ATP
            Sulfate
PRODUCT     Pyrophosphate
            Adenylylsulfate
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b2751(cysN) b2752(cysD)
            ECE: Z4059(cysN) Z4060(cysD)
            ECS: ECs3605 ECs3606
            YPE: YPO3365(cysN) YPO3366(cysD)
            XFA: XF1500 XF1501
            VCH: VC2559 VC2560
            PAE: PA4442(cysN) PA4443(cysD)
            BUC: BU423(cysN) BU424(cysD)
            NME: NMB1153 NMB1154 NMB1191 NMB1192
            NMA: NMA1364(cysN) NMA1365(cysD)
            CJE: Cj1609
            MLO: mlr7575 mlr7576
            SME: SMa0855(nodP1) SMa0857(nodQ1) SMb21223(nodP2) SMc00090(cysN)
                 SMc00091(cysD)
            CCR: CC1482 CC1483
            BSU: BG13106(yitA) BG13378(sat)
            BHA: BH1487 BH3386
            CAC: CAC0109(cysD) CAC0110(cysN)
            MTU: Rv1285(cysD) Rv1286(cysN)
            MTC: MT1323 MT1324
            SYN: slr1165(met3)
            DRA: DRA0016
            AAE: aq_1081(cysD)
            AFU: AF1667(sat)
            PAB: PAB1595(sat)
            APE: APE1197
            SSO: SSO2912(sat)
            SCE: YJR010W(MET3)
            SPO: SPBC28F2.01C(spbc28f2.01c) SPO21
            CEL: T14G10.1
            DME: CG8363(Paps)
            HSA: 9060(PAPSS2) 9061(PAPSS1)
MOTIF       PS: PS00301  D-[KRSTGANQFYW]-x(3)-E-[KRAQ]-x-[RKQD]-[GC]-[IVMK]-
                         [ST]-[IV]-x(2)-[GSTACKRNQ]
STRUCTURES  PDB: 1G8G  1G8F  1I2D  1G8H  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.4
            ExPASy - ENZYME nomenclature database: 2.7.7.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.4
            BRENDA, the Enzyme Database: 2.7.7.4
///
ENTRY       EC 2.7.7.5
NAME        Sulfate adenylyltransferase (ADP)
            ADP-sulfurylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ADP:sulfate adenylyltransferase
REACTION    ADP + Sulfate = Orthophosphate + Adenylylsulfate
SUBSTRATE   ADP
            Sulfate
PRODUCT     Orthophosphate
            Adenylylsulfate
PATHWAY     PATH: MAP00920  Sulfur metabolism
GENES       SCE: YCL050C(APA1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.5
            ExPASy - ENZYME nomenclature database: 2.7.7.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.5
            BRENDA, the Enzyme Database: 2.7.7.5
///
ENTRY       EC 2.7.7.6
NAME        DNA-directed RNA polymerase
            RNA nucleotidyltransferase (DNA-directed)
            RNA polymerase I
            RNA polymerase II
            RNA polymerase III
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
REACTION    Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1)
SUBSTRATE   Nucleoside triphosphate
            RNA(n)
PRODUCT     Pyrophosphate
            RNA(n+1)
COMMENT     Needs DNA as template.
            Catalyses DNA-template-directed extention of the 3'- end of an RNA
            strand by one nucleotide at a time. Can initiate a chain de novo.
            In eukaryotes, three forms of the enzyme have been distinguished
            on the basis of sensitivity to alpha-amanitin, and the type of RNA
            synthesized. See also EC 2.7.7.19 and 2.7.7.48.
            (EC 2.7.7.19 Polynucleotide adenylyltransferase)
            (EC 2.7.7.48 RNA-directed RNA polymerase)
            Utilizes only the S isomers of nucleotide triphosphates containing
            phosphorothioate at the alpha position; the phosphorothioate is
            converted to the R isomer upon incorporation into RNA.
            S(p)-conformer of ATP-alpha-S reacts to R(p) of A-P(S)-P because
            this reaction proceeds by inversion mechanism.
            P.M.J.Burgers and F.Eckstein, Proc.Natl.Acad.Sci.USA, 75,4798-4800
            (1978).  Review: 'Stereochemistry of enzymatic reaction of
            phosphates', P.A.Frey, Tetrahedron 38, 1541 (1982).
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP03020  RNA polymerase
GENES       ECO: b3295(rpoA) b3649(rpoZ) b3987(rpoB) b3988(rpoC)
            ECE: Z4665(rpoA) Z5075(rpoZ) Z5560(rpoB) Z5561(rpoC)
            ECS: ECs4160 ECs4524 ECs4910 ECs4911
            YPE: YPO0039(rpoZ) YPO0234(rpoA) YPO3746(rpoC) YPO3747(rpoB)
            HIN: HI0514(rpoC) HI0515(rpoB) HI0802(rpoA) HI1742(rpoZ)
            PMU: PM0921(rpoZ) PM1390(rpoA) PM1736(rpoC) PM1737(rpoB)
            XFA: XF1176 XF1502 XF2632 XF2633
            VCH: VC0328 VC0329 VC2571 VC2709
            PAE: PA4238(rpoA) PA4269(rpoC) PA4270(rpoB) PA5337(rpoZ)
            BUC: BU033(rpoC) BU034(rpoB) BU499(rpoA)
            NME: NMB0132 NMB0133 NMB0168 NMB1660
            NMA: NMA0103(rpoA) NMA0141(rpoC) NMA0142(rpoB) NMA1918(rpoZ)
            HPY: HP0776 HP1198(rpoB) HP1293(rpoA)
            HPJ: jhp0713 jhp1121 jhp1213
            CJE: Cj0478(rpoB) Cj0479(rpoC) Cj1273c(rpoZ) Cj1595(rpoA)
            RPR: RP140(rpoB) RP141(rpoC) RP578 RP635(rpoA)
            RCO: RC0181(rpoB) RC0182(rpoC) RC0882(rpoZ) RC0982(rpoA)
            MLO: mlr0276 mlr0277 mlr0325 mlr7753
            SME: SMa0892(dnaE3) SMc01285(rpoA) SMc01316(rpoC) SMc01317(rpoB)
                 SMc02408(rpoZ)
            ATU: AGR_C_3518 AGR_C_3568 AGR_C_3569
            CCR: CC0502 CC0503 CC1272 CC1552
            BSU: BG10409(rpoE) BG10728(rpoB) BG10729(rpoC) BG10732(rpoA)
                 BG13387(yloH)
            BHA: BH0126(rpoB) BH0127(rpoC) BH0162(rpoA) BH2511 BH3793(rpoE)
            SAU: SA0500(rpoB) SA0501(rpoC) SA1053 SA1930(rpoE) SA2023(rpoA)
            SAV: SAV0531(rpoB) SAV0532(rpoC) SAV1197 SAV2115(rpoE)
                 SAV2210(rpoA)
            LLA: L0136(rpoA) L0137(rpoB) L0138(rpoC) L0141(rpoE) L149295(ytgE)
            SPY: SPy0080(rpoA) SPy0098(rpoB) SPy0099(rpoC) SPy1630
                 SPy1895(rpoE)
            SPN: SP0236 SP0493 SP1737 SP1960 SP1961
            SPR: spr0215(rpoA) spr0437(rpoE) spr1776(rpoC) spr1777(rpoB)
            CAC: CAC1719(rpoZ) CAC3104(rpoA) CAC3142(rpoC) CAC3143(rpoB)
            MGE: MG022(rpoE) MG177(rpoA) MG340(rpoC) MG341(rpoB)
            MPN: B01_orf146(rpoE) F04_orf1290(rpoC) G12_orf1391o(rpoB)
                 GT9_orf327(rpoA)
            MPU: MYPU_5450(rpoC) MYPU_5460(rpoB) MYPU_5610(rpoA)
            UUR: UU187(rpoB) UU188(rpoC) UU257(rpoA) UU597(rpoE)
            MTU: Rv0667(rpoB) Rv0668(rpoC) Rv1390 Rv3457c(rpoA)
            MTC: MT0695 MT0696 MT1435 MT3564
            MLE: ML0542 ML1890(rpoC) ML1891(rpoB) ML1957(rpoA)
            CTR: CT314 CT315 CT507
            CMU: TC0588 TC0589 TC0794
            CPN: CPn0081 CPn0082 CPn0626
            CPA: CP0121 CP0693 CP0694
            CPJ: rpoA rpoB rpoC
            BBU: BB0388(rpoC) BB0389(rpoB) BB0502(rpoA)
            TPA: TP0212 TP0241 TP0242 TP0701
            SYN: sll1787(rpoB) sll1789(rpoC2) sll1818(rpoA) slr1265(rpoC1)
                 ssl2982
            DRA: DR0911 DR0912 DR2128 DR2494
            AAE: aq_070(rpoA) aq_183a(rpoZ) aq_1939(rpoB) aq_1945(rpoC)
            TMA: TM0458 TM0459 TM1472
            MJA: MJ0039 MJ0192(rpoD) MJ0196(rpoN) MJ0197(rpoK) MJ0387(rpoL)
                 MJ0396(rpoE2) MJ0397(rpoE1) MJ1039(rpoH) MJ1040(rpoB2)
                 MJ1041(rpoB1) MJ1042(rpoA1) MJ1043(rpoA2) MJ1148(rpm)
                 MJ1390(rpoI)
            MTH: MTH1048 MTH1049(rpoB2) MTH1050(rpoB1) MTH1051(rpoA1)
                 MTH1052(rpoA2) MTH1314 MTH1317 MTH1324 MTH264 MTH265 MTH297
                 MTH298 MTH299 MTH37 MTH40 MTH42
            AFU: AF0056 AF0207(rpoL) AF1116(rpoE2) AF1117(rpoE1) AF1130(rpoN)
                 AF1131(rpoK) AF1235 AF1530 AF1885(rpoH) AF1886(rpoB2)
                 AF1887(rpoB1) AF1888(rpoA1) AF1889(rpoA2) AF2282(rpoD)
            HAL: VNG0426G(rpoM) VNG0860G(rpoL) VNG1136G(rpb3) VNG1140G(rpoN)
                 VNG1141G(rpoK) VNG1169C VNG2051G(rpoE'') VNG2053G(rpoE')
                 VNG2662G(rpoC) VNG2664G(rpoA) VNG2665G(rpoB') VNG2666G(rpoB'')
                 VNG2668G(rpoH)
            TAC: Ta0389 Ta0390 Ta0391 Ta0392 Ta0431 Ta1006 Ta1030 Ta1089
                 Ta1090 Ta1160 Ta1298 Ta1416
            TVO: TVG0322900 TVG0469462 TVG0469653 TVG0551901 TVG0759000
                 TVG1188103 TVG1233699 TVG1235237 TVG1237894 TVG1241478
                 TVG1288113 TVG1510824
            PHO: PH0664 PH1127 PH1544 PH1545 PH1546 PH1632 PH1637 PH1908
                 PHS044 PHS056
            PAB: PAB0423(rpoB) PAB0424(rpoA1) PAB0425(rpoA2) PAB0732
                 PAB1105(rpoE1) PAB1464 PAB2316(rpoL) PAB2410(rpoD) PAB3072
                 PAB7131(rpoN) PAB7132(rpoK) PAB7151(rpoH) PAB7428(rpoE2)
            APE: APE0257 APE0442 APE0443 APE0549 APE0914 APE1744 APE1852
                 APE1853 APE1856 APES005 APES041 APES057 APES058 APES061
            SSO: SSO0071(rpoD) SSO0223(rpoA2) SSO0225(rpoA1) SSO0227(rpoB1)
                 SSO0277(rpoG) SSO0291(rpoM-1) SSO0415(rpoE1) SSO0751(rpoF)
                 SSO3254(rpoB2) SSO5140(rpoN) SSO5468(rpoH) SSO5576(rpoM-like)
                 SSO5577(rpoL) SSO5798(rpoE2) SSO5865(rpoP) SSO6768(rpoK)
                 SSO9221(rpoM-2)
            STO: ST0275 ST0276 ST0277 ST0379 ST0458 ST2067 STS038 STS052
                 STS136 STS221
            SCE: YBR154C(RPB5) YDL140C(RPO21) YDL150W(RPC53) YDR045C
                 YDR156W(RPA14) YDR404C(RPB7) YFL036W(RPO41) YGL070C(RPB9)
                 YHR143W-A(RPB12) YIL021W(RPB3) YJL140W(RPB4) YJL148W(RPA34)
                 YJR063W(RPA12) YKL144C(RPC25) YNL113W(RPC19) YNL151C(RPC31)
                 YNL248C(RPA49) YNR003C(RPC34) YOL005C(RPB11) YOR116C(RPO31)
                 YOR151C(RPB2) YOR207C(RET1) YOR210W(RPB10) YOR224C(RPB8)
                 YOR340C(RPA43) YOR341W(RPA190) YPR010C(RPA2) YPR110C(RPC40)
                 YPR187W(RPO26) YPR190C(RPC82)
            SPO: NUC1(nuc1) RPA43(rpa43) RPA49(rpa49) RPB1(rpb1) RPB10(rpb10)
                 RPB11(rpb11) RPB2_1(rpb2) RPB2_2(rpb2) RPB3(rpb3) RPB4(rpb4)
                 RPB5(rpb5) RPB6(rpb6) RPB7(rpb7) RPB8(rpb8) RPB9(rpb9)
                 RPC1(rpc1) RPC10(rpc10) RPC19(rpc19) RPC34(rpc34) RPC40(rpc40)
                 RPC53(rpc53) SPAC22A12.05 SPAC26H5.12(spac26h5.12) SPAC4G9.08C
                 SPBC2G5.07C(spbc2g5.07c) SPBP23A10.07(spbp23a10.07)
                 SPCC1259.03(spcc1259.03)
            ATH: At1g01210(F6F3.2) At1g06790(F4H5.12) At1g29940(T1P2.15)
                 At1g53690(F22G10.4) At1g54250(F20D21.7) At1g60620(F8A5.14)
                 At1g61700(T13M11.6) At1g63020(F16P17.19) At1g68990(T6L1.17)
                 At2g04630(F28I8.33) At2g15400(F26H6.8) At2g15430(F26H6.5)
                 At2g24120(F27D4.3) At2g29540(F16P2.8) At2g40030(T28M21.19)
                 At2g41340(F13H10.11) At3g16680(MGL6.11) At3g16980(K14A17.16)
                 At3g18090(MRC8.7) At3g22320(MCB17.20) At3g22900(F5N5.8)
                 At3g23780(MYM9.13) At3g49000(T2J13.160) At3g52090(F4F15.200)
                 At3g54490(T14E10.60) At3g57080(F24I3.160) At3g57660(F15B8.150)
                 At3g59600(T16L24.150) At4g07950(F1K3.2) At4g14520(dl3300w)
                 At4g14660(dl3370c) At4g21710(F17L22.170) At4g35800(F4B14.70)
                 At5g09920(MYH9.13) At5g15700(F14F8.80) At5g41010(MEE6.8)
                 At5g45140(K18C1.1) At5g51940(MSG15.2) At5g57980(MTI20.24)
                 At5g59180(MNC17.16) At5g60040(MGO3.13)
            CEL: C06A1.5 C15H11.8 C26E6.4 C36B1.3 C42D4.8(rpc-1) C48E7.2
                 F09F7.3 F14B4.3 F26F4.11 F43E2.1 F58A4.9 W01G7.3 W09C3.4
                 Y48E1A.1 ZK856.10 ama-1
            DME: CG10122(RpI1) CG10438 CG10685 CG11246 CG1163(RpABC14) CG11979
                 CG12267 CG13418 CG13628 CG1554(RpII215) CG17209
                 CG3180(RpII140) CG3284(RpII15) CG3756 CG4033(RpI135) CG4644
                 CG5147 CG5380 CG6572 CG6840 CG7339 CG7885(RpII33)
                 CG8344(RpIII128)
            HSA: 10621(RPC39) 10622(RPC32) 10623(RPC62) 11128(RPC155) 25885
                 30834(ZNRD1) 51082(LOC51082) 51728(POLR3K) 5430(POLR2A)
                 5431(POLR2B) 5432(POLR2C) 5433(POLR2D) 5434(POLR2E)
                 5435(POLR2F) 5436(POLR2G) 5437(POLR2H) 5438(POLR2I)
                 5439(POLR2J) 5440(POLR2K) 5441(POLR2L) 5442(POLRMT)
                 54479(FLJ10816) 55703(FLJ10388) 661(BN51T) 9533(RPA40)
DISEASE     MIM: 180660  Polymerase (RNA) II (DNA directed) polypeptide A,
                         220kD
            MIM: 180661  Polymerase (RNA) II (DNA directed) polypeptide B,
                         140kD
            MIM: 180662  Polymerase (RNA) II (DNA directed) polypeptide I,
                         14.5kD
            MIM: 180663  Polymerase (RNA) II (DNA directed) polypeptide C, 33kD
            MIM: 180664  Polymerase (RNA) II (DNA directed) polypeptide E, 25kD
            MIM: 602013  Polymerase (RNA) II (DNA directed) polypeptide G
MOTIF       PS: PS00028  C-x(2,4)-C-x(3)-[LIVMFYWC]-x(8)-H-x(3,5)-H
            PS: PS00115  Y-[ST]-P-[ST]-S-P-[STANK]
            PS: PS00446  N-[SGA]-[LIVMF]-R-R-x(9)-[SA]-x(3)-V-x(4)-N-x-[STA]-
                         x(3)-[DN]-E-x-[LI]-[GSA]-x-R-[LI]-[GAS]-[LIVM](2)-P
            PS: PS00466  C-x(2)-C-x(9)-[LIVMQSAR]-[QH]-[STQL]-[RA]-[SACR]-x-
                         [DE]-[DET]-[PGSEA]-x(6)-C-x(2,5)-C-x(3)-[FW]
            PS: PS00489  [LIVMF]-x-R-x(3)-K-x(2)-[LIVMF]-M-[PT]-x(2)-Y
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
            PS: PS00900  P-[LIVM]-x(2)-D-[GA]-[ST]-[AC]-[SN]-[GA]-[LIVMFY]-Q
            PS: PS01030  F-C-x-[DEKST]-C-[GNK]-[DNSA]-[LIVMH]-[LIVM]-x(8,14)-C-
                         x(2)-C
            PS: PS01110  H-[NQEIVM]-[LIVMY]-V-P-[EK]-H-x(2)-[LIVM]-x(2)-[DESA]-
                         [ET]
            PS: PS01111  [ST]-x-[FY]-E-x-[AT]-R-x-[LIVM]-[GSA]-x-R-[SA]-x-Q
            PS: PS01112  [LIVMFD]-[LIVMP]-P-[LIVM]-x-C-[FL]-[ST]-C-G
            PS: PS01154  E-x-H-[ST]-[LIVMFY]-x-N-x(11)-V-x-[FMVA]-x(2)-Y-x(3)-H-
                         P
            PS: PS01166  G-x-K-[LIVMFA]-[STAC]-[GSTN]-x-[HSTA]-[GS]-[QNH]-K-G-
                         [IVT]
STRUCTURES  PDB: 1I6H  1I50  1I3Q  1HQM  1EIK  4RNP  1I6V  1QLN  1BDF  1ARO  
                 1A1D  1EF4  1DZF  1CEZ  1QKL  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.6
            ExPASy - ENZYME nomenclature database: 2.7.7.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.6
            BRENDA, the Enzyme Database: 2.7.7.6
            SCOP (Structural Classification of Proteins): 2.7.7.6
///
ENTRY       EC 2.7.7.7
NAME        DNA-directed DNA polymerase
            DNA polymerase I, II, III
            DNA polymerase alpha, beta, gamma
            DNA nucleotidyltransferase (DNA-directed)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Deoxynucleotide-triphosphate:DNA deoxynucleotidyltransferase
            (DNA-directed)
REACTION    Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1)
SUBSTRATE   Deoxynucleoside triphosphate
            DNA(n)
PRODUCT     Pyrophosphate
            DNA(n+1)
COMMENT     Catalyses DNA-template-directed extension of the 3'- end of a DNA
            strand by one nucleotide at a time. Cannot initiate a chain de
            novo. Requires a primer which may by DNA or RNA.
            See also EC 2.7.7.49.
            (EC 2.7.7.49 RNA-directed DNA polymerase)
            Not a zinc enzyme and dose not require zinc for its enzymatic
            activities.
            #STRUCTURE:
            Crystal structure of DNA polymerase I from E. coli. Ollis et al.
            Nature, 313, 762-766 (1985).
            Smaller domain (324-517) and larger domain (518-).
            The smaller domain has 5'-3' exonuclease activity. The larger
            domain (Klenow fragment) has DNA polymerase and 3'-5' exonuclease
            activities.
            The smaller domain binds zinc and deoxythymidine monophosphate.
            This domain has 5'-3' exonuclease activity. Mostly parallel beta-
            pleated sheet with alpha-helices on both sides. This domain has
            strucutre reminiscent of the nucleotide-binding domains of kinases
            and dehydrogenases. However, there does not seem to be any strong
            structural homology between these proteins.
            The larger domain has a six-stranded anti-parallel beta-sheet.
            #SITE:
            Deoxynucleoside monophosphate: Binds to the smaller domain near
            the carboxyl end of <beta-strand 2>(Asp355, Glu357, Thr358).
            This position is generally similar to the location of the NAD-
            and ATP-binding regions in dehydrogenases and kinases.
            Metals (Zn2+, Mn2+, Sm3+, Mg2+): Interacts with both the protein
            and the <5'-phosphate of dTMP>. Bound to the protein by the
            carboxylate groups of <Asp355, Glu357, Asp501>.
            dTMP: Phosphate oxygen atoms are interacting with: (1)the metal
            ion; (2)the hydroxyl of Tyr497; (3)unknown small molecule lying
            between Tyr497 and Asp423. 3'-OH-group is H-bonded to the back-
            bone amide of Thr358. Thymidine base is bound by several
            surrounding hydrophobic protein side chains, Leu361 and Phe473.
            There are no specific H-bonding interactions between the thymine
            base and the protein.
            DNA: The J and K alpha-helices (676-680, 685-692) are placed
            partially into a major grove of B-DNA. The H and I alpha-helices
            (550-569, 626-647) close off the cleft after DNA binds.
            Mtations of Arg690 to His690, and Gly850 to Arg85 make defective
            in DNA binding and less processive, respectively ( Kelly and
            Grindley, Nucleic Acids Res., 3, 2971-2984, 1976; Matson et al.,
            J. Biol. Chem., 253, 7851-7856, 1968).
            Exonuclease activity: Point mutations of Asp424 to Ala424 and
            Asp355, Glu357 to Ala355, Ala357 induce loss of exonuclease
            activity (Derbyshire et al., Science, 240, 199-201, 1988).
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP03030  DNA polymerase
GENES       ECO: b0060(polB) b0184(dnaE) b0215(dnaQ) b0470(dnaX) b0640(holA)
                 b1099(holB) b1842(holE) b3701(dnaN) b3863(polA) b4259(holC)
                 b4372(holD)
            ECE: Z0068(polB) Z0196(dnaE) Z0241(dnaQ) Z0587(dnaX) Z0787(holA)
                 Z1738(holB) Z2891(holE) Z5192(dnaN) Z5398(polA) Z5871(holC)
                 Z5973(holD)
            ECS: ECs0064 ECs0186 ECs0211 ECs0523 ECs0678 ECs1477 ECs2552
                 ECs4636 ECs4786 ECs5236 ECs5330
            YPE: YPO0017(polA) YPO0428(holD) YPO0518(polB) YPO1059(dnaE)
                 YPO1082(dnaQ) YPO1606(holB) YPO1782(holE) YPO2608(holA)
                 YPO3122(dnaX) YPO3442(holC) YPO4096(dnaN)
            HIN: HI0011(holD) HI0137(dnaQ) HI0455(holB) HI0739(dnaE)
                 HI0856(polA) HI0923(holA) HI0992(dnaN) HI1229(dnaX)
                 HI1397(holC)
            PMU: PM0034(dnaE) PM0106(dnaQ) PM0364(dnaX) PM0822(holC)
                 PM0959(hold) PM1065(polA) PM1160(dnaN) PM1216(holA)
                 PM1674(holB)
            XFA: XF0002 XF0136 XF0204 XF0676 XF1103 XF1807 XF2157 XF2178
            VCH: VC0013 VC0108 VC0299 VC0656 VC0953 VC1054 VC1212 VC1290
                 VC2015 VC2233 VC2245 VC2502
            PAE: PA0002(dnaN) PA0669 PA1532(dnaX) PA1816(dnaQ) PA1886(polB)
                 PA2961(holB) PA3232 PA3640(dnaE) PA3832(holC) PA3989(holA)
                 PA5493(polA)
            BUC: BU011(dnaN) BU238(dnaE) BU248(dnaQ) BU354(holB) BU431(polA)
                 BU445(holA) BU481(dnaX)
            NME: NMB0708 NMB0769 NMB1451 NMB1514 NMB1568 NMB1827 NMB1902
                 NMB1982
            NMA: NMA0462(polA) NMA0553(dnaN) NMA0632(dnaE) NMA0913(holA)
                 NMA0980(holB) NMA1656(dnaZX) NMA1665 NMA1714(dnaQ)
                 NMA1757(holC)
            HPY: HP0500(dnaN) HP0717(dnaX) HP1231(holB) HP1387(dnaQ)
                 HP1460(dnaE) HP1470(polA)
            HPJ: jhp0452 jhp0655 jhp1152 jhp1353 jhp1363 jhp1438
            CJE: Cj0002(dnaN) Cj0338c(polA) Cj0452(dnaQ) Cj0718(dnaE) Cj0963
                 Cj1157(dnaX)
            RPR: RP172(holB) RP419(dnaN) RP732(dnaQ) RP776(polA) RP778(dnaE)
                 RP845 RP865(dnaX)
            RCO: RC0213(holB) RC0583(dnaN) RC1112(dnaQ) RC1206(polA)
                 RC1211(dnaE) RC1309 RC1336(dnaX)
            MLO: mll0423 mll0870 mll5580 mll7705 mlr3298 mlr4428 mlr4495
                 mlr5503
            SME: SMb21448 SMc00415(dnaN) SMc01190 SMc01375(dnaE1)
                 SMc02789(dnaQ) SMc02850(polA) SMc02905(dnaX) SMc03788(dnaE2)
            ATU: AGR_C_169
            CCR: CC0005 CC0156 CC0267 CC1333 CC1823 CC1926 CC3211 CC3464
            BSU: BG10066(dnaN) BG10083(dnaX) BG10095(holB) BG10263(polC)
                 BG12583(dnaE) BG12656(polA) BG13696(yorL)
            BHA: BH0002(dnaN) BH0034(dnaX) BH0044(holB) BH2418(polC)
                 BH3153(polA) BH3169(dnaE)
            SAU: SA0002(dnaN) SA0436(dnaX) SA0442(holB) SA1107(polC)
                 SA1513(polA) SA1525(dnaE)
            SAV: SAV0002(dnaN) SAV0465(dnaX) SAV0471(holB) SAV1252(polC)
                 SAV1676(polA) SAV1689(dnaE)
            LLA: L0270(polA) L0275(dnaN) L0278(polC) L0279(dnaH) L0280(holB)
                 L0307(dnaE) L9094(dnaQ)
            SPY: SPy0003(dnaN) SPy0185(polA) SPy0400 SPy1284(dnaE)
                 SPy1364(dnaX) SPy1864(dnaQ) SPy1961(polC)
            SPN: SP0002 SP0032 SP0274 SP0865 SP0895 SP0936 SP0993
            SPR: spr0002(dnaN) spr0032(polA) spr0251(polC) spr0769(dnaX)
                 spr0795(dnaE) spr0836(holB) spr0896(dnaQ)
            CAC: CAC0002(dnaN) CAC0125(dnaX) CAC0516(dnaE) CAC1098(polA)
                 CAC2997 CAC3442(polC)
            MGE: MG001(dnaN) MG007 MG031(polC) MG261(dnaE) MG419 MG420(dnax)
            MPN: A19_orf872(dnaE) B01_orf1443(polC) C12_orf681(dnaX)
                 D12_orf253(holB) K05_orf380(dnaN)
            MPU: MYPU_0020(dnaN) MYPU_0490(dnaX) MYPU_0530(dnaX)
                 MYPU_6750(polC) MYPU_7190(dnaE) MYPU_7200(polA)
            UUR: UU019(dnaH) UU079(dnaN) UU087(dnaX) UU377(polC) UU415(dnaE)
            MTU: Rv0002(dnaN) Rv1547(dnaE1) Rv1629(polA) Rv2191 Rv3370c(dnaE2)
                 Rv3644c Rv3711c(dnaQ) Rv3721c(dnaZX)
            MTC: MT0002 MT1598 MT1665 MT2247 MT3480 MT3747 MT3814 MT3824
            MLE: ML0002(dnaN) ML0202 ML1207(dnaE) ML1381(polA) ML2335(dnaZX)
            CTR: CT075 CT187 CT261 CT334 CT493 CT536 CT545
            CMU: TC0347 TC0459 TC0611 TC0780 TC0832
            CPN: CPn0040 CPn0272 CPn0338 CPn0410 CPn0612 CPn0655 CPn0666
            CPA: CP0081 CP0092 CP0135 CP0344 CP0419 CP0487 CP0735
            CPJ: dnaE dnaN dnaQ_1 dnaQ_2 dnaX_1 dnaX_2 polA
            BBU: BB0438(dnaN) BB0461(dnaX) BB0548(polA) BB0579(dnaE)
            TPA: TP0002 TP0105 TP0229 TP0521 TP0643 TP0669 TP1005
            SYN: sll1360(dnaX) sll1572(dnaE) slr0446(dnaX) slr0603(dnaE)
                 slr0707(polA) slr0965(dnaN)
            DRA: DR0001 DR0507 DR0856 DR1707 DR1751 DR2410
            AAE: aq_1008(dnaE) aq_1693(dplF) aq_1855(dnaX) aq_1882(dnaN)
                 aq_1967(polA) aq_2108 aq_932(dnaQ)
            TMA: TM0262 TM0461 TM0496 TM0511 TM0576 TM0686 TM1619
            MJA: MJ0702 MJ0885 MJ1630
            MTH: MTH1208 MTH1405 MTH1536 MTH208
            AFU: AF0497(polB) AF0972(dnaQ) AF1722 AF1790 AF2277
            HAL: VNG0521G(polB1) VNG2082G(polC) VNG2338G(polA2)
                 VNG2417G(polA1) VNG6362G(polB2)
            TAC: Ta0036 Ta0222 Ta0907
            TVO: TVG0041370 TVG0859451 TVG1442259
            PHO: PH0121 PH0123 PH1472 PH1947
            PAB: PAB0474 PAB1128(polI) PAB2266 PAB2404
            APE: APE0099 APE0427 APE2098 APE2229
            SSO: SSO0081(dpo3) SSO0552(dpo1) SSO1459(dpo2) SSO2275
            SCE: YBL035C(POL12) YBR278W(DPB3) YCR014C(POL4) YDL102W(CDC2)
                 YEL055C(POL5) YJR006W(HYS2) YNL102W(POL1) YNL262W(POL2)
                 YOR330C(MIP1) YPL167C(REV3) YPR175W(DPB2)
            SPO: CDC1(cdc1) CDC20(cdc20) MIP1_1(mip1) MIP1_2(mip1) POL1(pol1)
                 POL3(pol3) POL5(pol5) SPBP8B7.14C(spbp8b7.14c)
                 SPCC553.09C(spcc553.09c)
            ATH: At1g08260(T23G18.21) At1g10520(T10O24.13) At1g67500(T1F15.3)
                 At1g67630(F12B7.19) At2g02480(T8K22.22) At2g27120(T20P8.17)
                 At2g42120(T24P15.3) At3g20540(K10D20.8) At4g24790(F22K18.10)
                 At4g32700(F4D11.100) At5g63960(MBM17.6) At5g67100(K21H1.14)
            CEL: F08B4.5 F10C2.4 F12F6.7 F33H2.5 R01H10.1 W03A3.2
            DME: CG10489 CG12018(BcDNA:HL03874) CG1925 CG5923(DNApol-alpha73)
                 CG5949(DNApol-delta) CG6019(mus308) CG6349(DNApol-alpha180)
                 CG8969(DNApol-gamma35) CG8987(tam)
            MMU: 1097163(Pold2) 1196389(Polg) 1196391(Pole) 97740(Polb)
                 97741(Pold1) 99660(Pola1)
            HSA: 10721(POLQ) 11232(POLG2) 23649(POLA2) 5422(POLA) 5423(POLB)
                 5424(POLD1) 5425(POLD2) 5426(POLE) 5427(POLE2) 5428(POLG)
                 5980(REV3L)
DISEASE     MIM: 174760  Polymerase (DNA directed), beta
            MIM: 174761  Polymerase (DNA directed), delta 1, catalytic subunit
            MIM: 174762  Polymerase (DNA directed), epsilon
            MIM: 174763  Polymerase (DNA directed), gamma
            MIM: 312040  Polymerase (DNA directed), alpha
            MIM: 600815  Polymerase (DNA directed), delta 2, regulatory
                         subunit, 50kD
MOTIF       PS: PS00116  [YA]-[GLIVMSTAC]-D-T-D-[SG]-[LIVMFTC]-x-[LIVMSTAC]
            PS: PS00447  R-x(2)-[GSAV]-K-x(3)-[LIVMFY]-[AGQ]-x(2)-Y-x(2)-[GS]-
                         x(3)-[LIVMA]
            PS: PS00522  G-[SG]-[LFY]-x-R-[GE]-x(3)-[SGCL]-x-D-[LIVM]-D-
                         [LIVMFY](3)-x(2)-[SAP]
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
STRUCTURES  PDB: 1ZQV  1IH7  1WAG  1WAF  1TGO  1TAU  2KZZ  2KFZ  9ICY  9ICX  
                 9ICW  9ICV  9ICU  9ICT  9ICS  1TAQ  1T7P  9ICR  9ICQ  9ICP  
                 9ICO  9ICN  9ICM  9ICL  1QTM  1QSY  1QSS  1QSL  9ICK  9ICJ  
                 9ICI  9ICH  9ICG  9ICF  9ICE  9ICC  9ICB  9ICA  8ICZ  8ICY  
                 8ICX  8ICW  8ICV  8ICU  8ICT  8ICS  8ICR  8ICQ  8ICP  8ICO  
                 8ICN  8ICM  8ICL  8ICK  8ICJ  8ICI  8ICH  8ICG  8ICF  8ICE  
                 8ICC  8ICB  8ICA  7ICV  7ICU  7ICT  7ICS  7ICR  7ICQ  7ICP  
                 7ICO  7ICN  7ICM  7ICL  7ICK  7ICJ  7ICI  7ICH  7ICG  7ICF  
                 7ICE  5KTQ  4KTQ  3KTQ  2POL  2KFN  2KZM  2KTQ  1KSP  1KLN  
                 2BPG  2BPF  2BPC  1ZQZ  1ZQY  1ZQX  1ZQW  1QQC  1ZQU  1ZQT  
                 1ZQS  1ZQR  1ZQQ  1ZQP  1ZQO  1ZQN  1ZQM  1ZQL  1ZQK  1ZQJ  
                 1ZQI  1ZQH  1ZQG  1ZQF  1ZQE  1ZQD  1ZQC  1ZQB  1ZQA  1XWL  
                 1WAJ  1WAI  1QHT  1NOZ  1NOY  1NOM  1KTQ  1KFS  1KRP  1CLQ  
                 1CMW  1KFD  1JXL  1JXE  1JX4  1D1U  1D8Y  1A5T  1B1F  1BGX  
                 1BNO  1BNP  1BPB  1BPD  1BPE  1BPX  1BPY  1BPZ  1D9D  1DU2  
                 1JR3  1D5A  1JQL  1DPI  1D9F  1DK2  1DK3  1DML  1JN3  1GCX  
                 1HUO  1HUZ  1IG9  1WAH  1IM4  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.7
            ExPASy - ENZYME nomenclature database: 2.7.7.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.7
            BRENDA, the Enzyme Database: 2.7.7.7
            SCOP (Structural Classification of Proteins): 2.7.7.7
///
ENTRY       EC 2.7.7.8
NAME        Polyribonucleotide nucleotidyltransferase
            Polynucleotide phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Polyribonucleotide:orthophosphate nucleotidyltransferase
REACTION    RNA(n+1) + Orthophosphate = RNA(n) + a Nucleoside diphosphate
SUBSTRATE   RNA(n+1)
            ADP
            IDP
            GDP
            UDP
            CDP
            Orthophosphate
PRODUCT     RNA(n)
            Nucleoside diphosphate
COMMENT     ADP, IDP, GDP, UDP and CDP can act as donors.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b3164(pnp)
            ECE: Z4525(pnp)
            ECS: ECs4045
            YPE: YPO3490(pnp)
            HIN: HI0229(PNP)
            PMU: PM1114(pnp)
            XFA: XF0239
            VCH: VC0647
            PAE: PA4740(pnp)
            BUC: BU373(pnp)
            NME: NMB0758
            NMA: NMA0969(pnp)
            HPY: HP1213(pnp)
            HPJ: jhp1136
            CJE: Cj1253(pnp)
            RPR: RP504(pnp)
            RCO: RC0663(pnp)
            MLO: mlr5562
            SME: SMc00324(pnp)
            ATU: AGR_C_124
            CCR: CC0034
            BSU: BG11491(pnpA)
            BHA: BH2407(pnpA)
            SAU: SA1117(pnpA)
            SAV: SAV1262(pnpA)
            LLA: L0325(pnpA)
            SPY: SPy1946(pnpA)
            SPN: SP0588
            SPR: spr0516(pnpA)
            CAC: CAC1808(pnpA)
            MTU: Rv2783c(gpsI)
            MTC: MT2853
            MLE: ML0854(gpsI)
            CTR: CT842
            CMU: TC0230
            CPN: CPn0999
            CPA: CP0855
            CPJ: pnp
            BBU: BB0805(pnpA)
            TPA: TP0886
            SYN: sll1043(pnp)
            DRA: DR2063
            AAE: aq_221(phpA)
            TMA: TM1345
            DME: CG11337
STRUCTURES  PDB: 1E3P  1E3H  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.8
            ExPASy - ENZYME nomenclature database: 2.7.7.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.8
            BRENDA, the Enzyme Database: 2.7.7.8
            SCOP (Structural Classification of Proteins): 2.7.7.8
///
ENTRY       EC 2.7.7.9
NAME        UTP--glucose-1-phosphate uridylyltransferase
            UDPglucose pyrophosphorylase
            Glucose-1-phosphate uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:alpha-D-glucose-1-phosphate uridylyltransferase
REACTION    UTP + alpha-D-Glucose 1-phosphate = Pyrophosphate + UDPglucose
SUBSTRATE   UTP
            alpha-D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            UDPglucose
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b1236(galU) b2042(galF)
            ECE: Z2012(galU) Z3205(galF)
            ECS: ECs1738 ECs2846
            YPE: YPO1539(galU) YPO1540(galF)
            HIN: HI0812(galU)
            PMU: PM1289(galU)
            XFA: XF2432
            VCH: VC0395
            PAE: PA2023(galU)
            NME: NMB0638
            NMA: NMA0848(galU)
            HPY: HP0646(galU)
            HPJ: jhp0591
            CJE: Cj1536c(galU)
            MLO: mll3025 mlr5275
            SME: SMb20960(exoN) SMc04023(exoN2)
            CCR: CC3637
            BSU: BG10402(gtaB) BG11199(ytdA) BG13453(yngB)
            BHA: BH2303 BH3652 BH3717(gtaB)
            SAU: SA2288(gtaB)
            SAV: SAV2483(gtaB)
            LLA: L177590(hasC)
            SPY: SPy0224(hasC.2) SPy2202(hasC)
            SPN: SP2092
            SPR: spr1903(galU)
            CAC: CAC2250 CAC2335
            MGE: MG453(galu)
            MPN: K05_orf291(gtaB)
            MTU: Rv0993(galU)
            MTC: MT1022
            MLE: ML0182(galU)
            BBU: BB0207(gtaB)
            AAE: aq_1705(galF)
            MJA: MJ1334
            MTH: MTH634
            PAB: PAB0771
            SSO: SSO0813
            SCE: YHL012W YKL035W(UGP1)
            SPO: SPCC1322.04(spcc1322.04) SPCC794.10(spcc794.10)
            CEL: K08E3.5a K08E3.5b K08E3.5c
            DME: CG4347 CG4347_1
            HSA: 7359(UGP1) 7360(UGP2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.9
            ExPASy - ENZYME nomenclature database: 2.7.7.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.9
            BRENDA, the Enzyme Database: 2.7.7.9
///
ENTRY       EC 2.7.7.10
NAME        UTP--hexose-1-phosphate uridylyltransferase
            Galactose-1-phosphate uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:alpha-D-hexose-1-phosphate uridylyltransferase
REACTION    UTP + alpha-D-Galactose 1-phosphate = Pyrophosphate + UDPgalactose
SUBSTRATE   UTP
            alpha-D-Galactose 1-phosphate
            alpha-D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            UDPgalactose
            UDPglucose
COMMENT     alpha-D-Glucose 1-phosphate can also act as acceptor, more slowly.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b0758(galT)
            ECE: Z0928(galT)
            ECS: ECs0786
            YPE: YPO1138(galT)
            HIN: HI0820(galT)
            PMU: PM1036(galT)
            VCH: VC1596
            BSU: BG10582(galT)
            BHA: BH1109(galT)
            LLA: L0027(galT)
            SPN: SP1829 SP1852
            SPR: spr1648(galT) spr1667(galT)
            CAC: CAC2844(galT) CAC2961(galT)
            MTU: Rv0618(galT') Rv0619(galT)
            TMA: TM0896 TM1191
            PHO: PH0365
            SCE: YBR018C(GAL7)
            CEL: ZK1058.3
            HSA: 2592(GALT)
DISEASE     MIM: 230400  Galactose-1-phosphate uridyltransferase
MOTIF       PS: PS00117  F-E-N-[RK]-G-x(3)-G-x(4)-H-P-H-x-Q
            PS: PS01163  D-L-P-I-V-G-G-[ST]-[LIVM](2)-[STA]-H-[DEN]-H-[FY]-Q-G-G
STRUCTURES  PDB: 1GUQ  1HXP  1GUP  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.10
            ExPASy - ENZYME nomenclature database: 2.7.7.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.10
            BRENDA, the Enzyme Database: 2.7.7.10
            SCOP (Structural Classification of Proteins): 2.7.7.10
///
ENTRY       EC 2.7.7.11
NAME        UTP--xylose-1-phosphate uridylyltransferase
            Xylose-1-phosphate uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:alpha-D-xylose-1-phosphate uridylyltransferase
REACTION    UTP + alpha-D-Xylose 1-phosphate = Pyrophosphate + UDPxylose
SUBSTRATE   UTP
            alpha-D-Xylose 1-phosphate
PRODUCT     Pyrophosphate
            UDPxylose
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.11
            ExPASy - ENZYME nomenclature database: 2.7.7.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.11
            BRENDA, the Enzyme Database: 2.7.7.11
///
ENTRY       EC 2.7.7.12
NAME        UDPglucose--hexose-1-phosphate uridylyltransferase
            Uridyl transferase
            Hexose-1-phosphate uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase
REACTION    UDPglucose + alpha-D-Galactose 1-phosphate =
            alpha-D-Glucose 1-phosphate + UDPgalactose
SUBSTRATE   UDPglucose
            alpha-D-Galactose 1-phosphate
PRODUCT     alpha-D-Glucose 1-phosphate
            UDPgalactose
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       MMU: 95638(Galt)
STRUCTURES  PDB: 1HXQ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.12
            ExPASy - ENZYME nomenclature database: 2.7.7.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.12
            BRENDA, the Enzyme Database: 2.7.7.12
            SCOP (Structural Classification of Proteins): 2.7.7.12
///
ENTRY       EC 2.7.7.13
NAME        Mannose-1-phosphate guanylyltransferase
            GTP--mannose-1-phosphate guanylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:alpha-D-mannose-1-phosphate guanylyltransferase
REACTION    GTP + alpha-D-Mannose 1-phosphate = Pyrophosphate + GDPmannose
SUBSTRATE   GTP
            alpha-D-Mannose 1-phosphate
PRODUCT     Pyrophosphate
            GDPmannose
COMMENT     The bacterial enzyme can also use ITP and dGTP as donors.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       CAC: CAC2981
            MTU: Rv3264c(rmlA2)
            MTC: MT3364
            MLE: ML0753(rmlA2)
            SYN: sll1496 sll1558
            DRA: DR0710
            AAE: aq_718(mpg)
            MTH: MTH1759
            TAC: Ta1486
            TVO: TVG0079558
            PHO: PH1022 PH1697
            PAB: PAB0317(mpg) PAB0645
            APE: APE0255
            SSO: SSO0317
            SCE: YDL055C(PSA1)
            SPO: SPCC1906.01(spcc1906.01)
            CEL: C42C1.5
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.13
            ExPASy - ENZYME nomenclature database: 2.7.7.13
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.13
            BRENDA, the Enzyme Database: 2.7.7.13
///
ENTRY       EC 2.7.7.14
NAME        Ethanolamine-phosphate cytidylyltransferase
            Phosphorylethanolamine transferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:ethanolamine-phosphate cytidylyltransferase
REACTION    CTP + Ethanolamine phosphate = Pyrophosphate + CDPethanolamine
SUBSTRATE   CTP
            Ethanolamine phosphate
PRODUCT     Pyrophosphate
            CDPethanolamine
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       SPO: SPAC15E1.05C(spac15e1.05c)
            HSA: 5833(PCYT2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.14
            ExPASy - ENZYME nomenclature database: 2.7.7.14
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.14
            BRENDA, the Enzyme Database: 2.7.7.14
///
ENTRY       EC 2.7.7.15
NAME        Choline-phosphate cytidylyltransferase
            Phosphorylcholine transferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:choline-phosphate cytidylyltransferase
REACTION    CTP + Choline phosphate = Pyrophosphate + CDPcholine
SUBSTRATE   CTP
            Choline phosphate
PRODUCT     Pyrophosphate
            CDPcholine
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       SCE: YGR202C(PCT1)
            CEL: F08C6.2
            DME: CG18330
            MMU: 88557(Ctpct)
            HSA: 5130(PCYT1A)
DISEASE     MIM: 123695  Phosphate cytidylyltransferase 1, choline, alpha
                         isoform
STRUCTURES  PDB: 1PEH  1PEI  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.15
            ExPASy - ENZYME nomenclature database: 2.7.7.15
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.15
            BRENDA, the Enzyme Database: 2.7.7.15
            SCOP (Structural Classification of Proteins): 2.7.7.15
///
ENTRY       EC 2.7.7.16
NAME        Transferred to EC 3.1.27.5
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
COMMENT     Transferred entry. Now EC 3.1.27.5 - Pancreatic ribonuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.16
            ExPASy - ENZYME nomenclature database: 2.7.7.16
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.16
///
ENTRY       EC 2.7.7.17
NAME        Transferred to EC 3.1.27.1
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
COMMENT     Transferred entry. Now EC 3.1.27.1 - Ribonuclease T2.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.17
            ExPASy - ENZYME nomenclature database: 2.7.7.17
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.17
///
ENTRY       EC 2.7.7.18
NAME        Nicotinate-nucleotide adenylyltransferase
            Deamido-NAD+ pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:nicotinate-ribonucleotide adenylyltransferase
REACTION    ATP + Nicotinate D-ribonucleotide = Pyrophosphate + Deamino-NAD+
SUBSTRATE   ATP
            Nicotinate D-ribonucleotide
PRODUCT     Pyrophosphate
            Deamino-NAD+
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b0639(ybeN)
            ECE: Z0786(ybeN)
            ECS: ECs0677
            YPE: YPO2607(nadD)
            XFA: XF2179
            PAE: PA4006
            BUC: BU446(ybeN)
            NME: NMB2024
            NMA: NMA0416
            HPY: HP1337
            HPJ: jhp1256
            CJE: Cj1404
            MLO: mll4008
            BSU: BG11638(nadD)
            BHA: BH1326
            SAU: SA1422
            SAV: SAV1582
            LLA: L106374(ylaE)
            SPY: SPy0308
            SPN: SP1747
            CAC: CAC1262
            MTU: Rv2421c
            MTC: MT2494
            MLE: ML1454
            BBU: BB0782
            TPA: TP0741
            SYN: sll1916
            AAE: aq_036
            TMA: TM0097
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.18
            ExPASy - ENZYME nomenclature database: 2.7.7.18
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.18
            BRENDA, the Enzyme Database: 2.7.7.18
///
ENTRY       EC 2.7.7.19
NAME        Polynucleotide adenylyltransferase
            NTP polymerase
            RNA adenylating enzyme
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:polynucleotide adenylyltransferase
REACTION    ATP + RNA(n) = Pyrophosphate + RNA(n+1)
SUBSTRATE   ATP
            RNA(n)
PRODUCT     Pyrophosphate
            RNA(n+1)
COMMENT     Also acts slowly with CTP. Catalyses template-independent
            extension of the 3'- and of a DNA strand by one nucleotide at a
            time. Cannot initiate a chain de novo. The primer, depending on
            the source of the enzyme, may be an RNA or DNA fragment or
            oligo(A) bearing 3'-OH terminal group. See also EC 2.7.7.6.
GENES       ECO: b0143(pcnB)
            ECE: Z0154(pcnB)
            ECS: ECs0147
            YPE: YPO3399(pcnB)
            HIN: HI0063(pcnB)
            PMU: PM0864(pcnB)
            XFA: XF0227
            VCH: VC0594
            PAE: PA4727(pcnB)
            NME: NMB0843
            NMA: NMA1053(pcnB)
            HPY: HP0640(papS)
            HPJ: jhp0583
            RPR: RP015(pcnB)
            RCO: RC0015(pcnB)
            MLO: mll2726
            CCR: CC0408
            BHA: BH1684(papS)
            SAU: SA1290
            SAV: SAV1446(papS)
            LLA: L0324(papL)
            SPY: SPy0866(papS)
            SPN: SP1554
            SPR: spr1413(cca)
            MTU: Rv3907c(pcnA)
            MTC: MT4026
            MLE: ML2697(pcnA)
            CTR: CT410 CT704
            CMU: TC0077 TC0691
            CPN: CPn0845 CPn0966
            CPA: CP0894 CP1024
            CPJ: pcnB_1 pcnB_2
            BBU: BB0706(papS)
            TPA: TP0270 TP0596
            SYN: sll0825(pcnB) sll1253(pcnB)
            AAE: aq_2158(pcnB2) aq_411(pcnB1)
            TMA: TM0715
            SCE: YKR002W(PAP1)
            SPO: PLA1(pla1)
            CEL: F55B12.4 T15H9.6 Y32F6A.3
            HSA: 5068(PAP)
DISEASE     MIM: 167805  Pancreatitis-associated protein
STRUCTURES  PDB: 1AV6  1B42  1BKY  1EAM  1EQA  1F5A  1FA0  1P39  1V39  1VP3  
                 1VP9  1VPT  2VP3  3MAG  3MCT  4DCG  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.19
            ExPASy - ENZYME nomenclature database: 2.7.7.19
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.19
            BRENDA, the Enzyme Database: 2.7.7.19
            SCOP (Structural Classification of Proteins): 2.7.7.19
///
ENTRY       EC 2.7.7.20
NAME        Deleted entry
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
COMMENT     Deleted entry. This entry was identical with EC 2.7.7.25,
            tRNA adenylyltransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.20
            ExPASy - ENZYME nomenclature database: 2.7.7.20
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.20
///
ENTRY       EC 2.7.7.21
NAME        tRNA cytidylyltransferase
            tRNA CCA-pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:tRNA cytidylyltransferase
REACTION    CTP + tRNA(n) = Pyrophosphate + tRNA(n+1)
SUBSTRATE   CTP
            tRNA(n)
PRODUCT     Pyrophosphate
            tRNA(n+1)
COMMENT     May be identical with EC 2.7.7.25.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.21
            ExPASy - ENZYME nomenclature database: 2.7.7.21
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.21
            BRENDA, the Enzyme Database: 2.7.7.21
///
ENTRY       EC 2.7.7.22
NAME        Mannose-1-phosphate guanylyltransferase (GDP)
            GDPmannose phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GDP:D-mannose-1-phosphate guanylyltransferase
REACTION    GDP + D-Mannose 1-phosphate = Orthophosphate + GDPmannose
SUBSTRATE   GDP
            D-Mannose 1-phosphate
PRODUCT     Orthophosphate
            GDPmannose
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2049(manC)
            ECE: Z3195(manC) Z3213(cpsB)
            ECS: ECs2836 ECs2854
            XFA: XF0259
            VCH: VC0241
            PAE: PA2232 PA3551(algA) PA5452(wbpW)
            HPY: HP0043(pmi)
            HPJ: jhp0037
            MLO: mlr5802(NoeJ) mlr7607
            SME: SMb21082(manC/manA)
            CCR: CC3618
            CAC: CAC2968 CAC3058 CAC3072
            SYN: sll1370(rfbM) slr0493(rfbM) slr2074(manA)
            DRA: DRA0032
            AAE: aq_589(xanB)
            TMA: TM1033
            AFU: AF1097(manC)
            HAL: VNG2159G(manC)
            PHO: PH0925
            PAB: PAB0818(manC)
            HSA: 29925(GMPPB) 29926(GMPPA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.22
            ExPASy - ENZYME nomenclature database: 2.7.7.22
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.22
            BRENDA, the Enzyme Database: 2.7.7.22
///
ENTRY       EC 2.7.7.23
NAME        UDP-N-acetylglucosamine pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
REACTION    UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate = Pyrophosphate +
            UDP-N-acetyl-D-glucosamine
SUBSTRATE   UTP
            N-Acetyl-alpha-D-glucosamine 1-phosphate
PRODUCT     Pyrophosphate
            UDP-N-acetyl-D-glucosamine
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3730(glmU)
            ECE: Z5228(glmU)
            ECS: ECs4672
            YPE: YPO4119(glmU)
            HIN: HI0642(glmU)
            PMU: PM1806(glmU)
            XFA: XF1140
            VCH: VC2762
            PAE: PA5552(glmU)
            BUC: BU027(glmU)
            NME: NMB0038
            NMA: NMA0284(glmU)
            HPY: HP0683(glmU)
            HPJ: jhp0624
            CJE: Cj0821(glmU)
            RPR: RP454(glmU)
            RCO: RC0680(glmU)
            MLO: mll0836
            SME: SMc00232(glmU)
            CCR: CC2304
            BSU: BG10113(gcaD)
            BHA: BH0065(gcaD)
            SAU: SA0457(gcaD)
            LLA: L134450(glmU)
            SPY: SPy0443(gcaD)
            SPN: SP0988
            SPR: spr0891(gcaD)
            CAC: CAC3222(gcaD)
            MTU: Rv1018c(glmU)
            MTC: MT1046
            MLE: ML0249(glmU)
            CTR: CT629
            CMU: TC0918
            CPN: CPn0749
            CPA: CP1124
            CPJ: glmU
            SYN: sll0899(glmU)
            DRA: DR0808
            AAE: aq_607(glmU)
            TMA: TM1629
            MTH: MTH590
            SCE: YDL103C(QRI1)
            SPO: SPBC1289.08(spbc1289.08)
            ATH: At2g35020(F19I3.25)
            CEL: C36A4.4
            DME: CG9535(BcDNA:LD24639)
            HSA: 6675(UAP1)
MOTIF       PS: PS00101  [LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-x(3)-[LIVAC]-x-[LIV]-
                         [GAED]-x(2)-[STAVR]-x-[LIV]-[GAED]-x(2)-[STAV]-x-[LIV]-
                         x(3)-[LIV]
STRUCTURES  PDB: 1HV9  1G97  1G95  1FXJ  1FWY  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.23
            ExPASy - ENZYME nomenclature database: 2.7.7.23
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.23
            BRENDA, the Enzyme Database: 2.7.7.23
            SCOP (Structural Classification of Proteins): 2.7.7.23
///
ENTRY       EC 2.7.7.24
NAME        Glucose-1-phosphate thymidylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
REACTION    dTTP + alpha-D-Glucose 1-phosphate = Pyrophosphate + dTDPglucose
SUBSTRATE   dTTP
            alpha-D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            dTDPglucose
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
            PATH: MAP00522  Erythromycin biosynthesis
GENES       ECO: b2039(rfbA) b3789(rffH)
            ECE: Z5300(rffH)
            ECS: ECs4722
            YPE: YPO3861(rffH)
            XFA: XF0256
            PAE: PA5163(rmlA)
            NME: NMB0062 NMB0080
            NMA: NMA0188(rfbA2) NMA0205(rfbA)
            MLO: mlr7550
            SME: SMb21324(expA7)
            CCR: CC1141
            BSU: BG10617(spsI)
            BHA: BH3363(spsI)
            LLA: L197041(rmlA)
            SPY: SPy0933(cpsFO)
            SPR: spr0320(cps2L)
            CAC: CAC2333(spsI)
            MTU: Rv0334(rmlA)
            MTC: MT0348
            MLE: ML2503(rfbA)
            SYN: sll0207(rfbA)
            DRA: DRA0031 DRA0042
            AAE: aq_1367(spsI)
            TMA: TM0862
            MJA: MJ1101(strD)
            MTH: MTH1589 MTH1791
            AFU: AF0242(graD-1) AF0325(graD-2)
            HAL: VNG0008G(graD5) VNG0009G(graD2) VNG0047G(graD6)
                 VNG0064G(graD3) VNG0390G(graD1) VNG1055G(graD4)
            TAC: Ta1074
            TVO: TVG0519949 TVG0948272
            PHO: PH0380 PH0413 PH1219 PH1925
            PAB: PAB0784(graD-3) PAB1053(graD-1) PAB1115(graD-2) PAB2433
            APE: APE1181 APE1202 APE1208 APE1516 APE2291
            SSO: SSO0745 SSO0831 SSO1782
            STO: ST0452
STRUCTURES  PDB: 1G2V  1FZW  1G0R  1G23  1G1L  1G3L  1IIM  1IIN  1FXO  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.24
            ExPASy - ENZYME nomenclature database: 2.7.7.24
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.24
            BRENDA, the Enzyme Database: 2.7.7.24
            SCOP (Structural Classification of Proteins): 2.7.7.24
///
ENTRY       EC 2.7.7.25
NAME        tRNA adenylyltransferase
            tRNA CCA-pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:tRNA adenylyltansferase
REACTION    ATP + tRNA(n) = Pyrophosphate + tRNA(n+1)
SUBSTRATE   ATP
            tRNA(n)
PRODUCT     Pyrophosphate
            tRNA(n+1)
COMMENT     May be identical with EC 2.7.7.21 (tRNA cytidylyltransferase)
GENES       ECO: b3056(cca)
            ECE: Z4409(cca)
            ECS: ECs3939
            YPE: YPO0650(cca)
            HIN: HI1606(cca)
            PMU: PM0247(cca)
            XFA: XF1362
            VCH: VC2446
            PAE: PA0584(cca)
            BUC: BU061(cca)
            NME: NMB1241
            NMA: NMA1410(cca)
            CJE: Cj0789
            BSU: BG11208(cca)
            DRA: DR0983 DR1191
            MJA: MJ1111(cca)
            MTH: MTH584
            AFU: AF2156(cca)
            HAL: VNG0137G(cca)
            TAC: Ta1446
            TVO: TVG0124714
            PHO: PH0101
            PAB: PAB0063(cca)
            APE: APE1791
            SSO: SSO1039
            STO: ST0952
            SCE: YER168C(CCA1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.25
            ExPASy - ENZYME nomenclature database: 2.7.7.25
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.25
            BRENDA, the Enzyme Database: 2.7.7.25
///
ENTRY       EC 2.7.7.26
NAME        Transferred to EC 3.1.27.3
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
COMMENT     Transferred entry. Now EC 3.1.27.3 - Ribonuclease T1.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.26
            ExPASy - ENZYME nomenclature database: 2.7.7.26
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.26
///
ENTRY       EC 2.7.7.27
NAME        Glucose-1-phosphate adenylyltransferase
            ADPglucose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:alpha-D-glucose-1-phosphate adenyltransferase
REACTION    ATP + alpha-D-Glucose 1-phosphate = Pyrophosphate + ADPglucose
SUBSTRATE   ATP
            alpha-D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            ADPglucose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3430(glgC)
            ECE: Z4792(glgC)
            ECS: ECs4275
            YPE: YPO3940(glgC)
            HIN: HI1359(glgC)
            PMU: PM0543(glgC)
            VCH: VC1727 VCA0699
            MLO: mlr7588
            SME: SMc03923(glgC)
            ATU: AGR_L_1560
            BSU: BG10908(glgC)
            BHA: BH1087(glgC)
            LLA: L95975(glgC)
            SPR: spr1030(glgC)
            CAC: CAC2237(glgC)
            MTU: Rv1213(glgC)
            MTC: MT1251
            MLE: ML1069(glgC)
            CTR: CT489
            CMU: TC0776
            CPN: CPn0607
            CPA: CP0140
            CPJ: glgC
            SYN: slr1176(glgC)
            DRA: DR1689 DR1824
            TMA: TM0239 TM0240
            ATH: At2g21590(F2G1.14) At4g39210(T22F8.110)
MOTIF       PS: PS00808  [AG]-G-G-x-G-[STK]-x-L-x(2)-L-[TA]-x(3)-A-x-P-A-[LV]
            PS: PS00809  W-[FY]-x-G-[ST]-A-[DNSH]-[AS]-[LIVMFYW]
            PS: PS00810  [APV]-[GS]-M-G-[LIVMN]-Y-[IVC]-[LIVMFY]-x(2)-[DENPHK]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.27
            ExPASy - ENZYME nomenclature database: 2.7.7.27
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.27
            BRENDA, the Enzyme Database: 2.7.7.27
///
ENTRY       EC 2.7.7.28
NAME        Nucleoside-triphosphate--hexose-1-phosphate
            $ nucleotidyltransferase
            NDPhexose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     NTP:hexose-1-phosphate nucleotidyltransferase
REACTION    Nucleoside triphosphate + Hexose 1-phosphate = Pyrophosphate +
            NDPhexose
SUBSTRATE   Nucleoside triphosphate
            Hexose 1-phosphate
            GTP
            D-Glucose 1-phosphate
            D-Mannose 1-phosphate
PRODUCT     Pyrophosphate
            NDPhexose
            GDPglucose
            GDPmannose
COMMENT     In decreasing order of activity, guanosine, inosine and adenosine
            diphosphate hexoses are substrates in the reverse reaction with
            either glucose or mannose as the sugar.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.28
            ExPASy - ENZYME nomenclature database: 2.7.7.28
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.28
            BRENDA, the Enzyme Database: 2.7.7.28
///
ENTRY       EC 2.7.7.29
NAME        Hexose-1-phosphate guanylyltransferase
            GDPhexose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:alpha-D-hexose-1-phosphate gluanylyltransferase
REACTION    GTP + alpha-D-Hexose 1-phosphate = Pyrophosphate + GDPhexose
SUBSTRATE   GTP
            alpha-D-Hexose 1-phosphate
PRODUCT     Pyrophosphate
            GDPhexose
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.29
            ExPASy - ENZYME nomenclature database: 2.7.7.29
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.29
            BRENDA, the Enzyme Database: 2.7.7.29
///
ENTRY       EC 2.7.7.30
NAME        Fucose-1-phosphate guanylyltransferase
            GDPfucose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:L-fucose-1-phosphate guanylyltransferase
REACTION    GTP + L-Fucose 1-phosphate = Pyrophosphate + GDP-L-fucose
SUBSTRATE   GTP
            L-Fucose 1-phosphate
PRODUCT     Pyrophosphate
            GDP-L-fucose
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       HSA: 8790(FPGT)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.30
            ExPASy - ENZYME nomenclature database: 2.7.7.30
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.30
            BRENDA, the Enzyme Database: 2.7.7.30
///
ENTRY       EC 2.7.7.31
NAME        DNA nucleotidylexotransferase
            Terminal deoxyribonucleotidyltransferase
            Terminal addition enzyme
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Nucleoside-triphosphate:DNA deoxynucleotidylexotransferase
REACTION    Deoxynucleoside triphosphate + DNA(n) =
            Pyrophosphate + DNA(n+1)
SUBSTRATE   Deoxynucleoside triphosphate
            DNA(n)
PRODUCT     Pyrophosphate
            DNA(n+1)
COMMENT     Catalyses template-independent extension of the 3'- end of a DNA
            strand by one nucleotide at a time. Cannot initiate a chain de
            novo. Nucleoside may be ribo- or deoxyribo-.
            3 and a 3'-OH is required.
GENES       MMU: 98659(Tdt)
            HSA: 1791(DNTT)
DISEASE     MIM: 187410  Terminal deoxynucleotidyltransferase
MOTIF       PS: PS00522  G-[SG]-[LFY]-x-R-[GE]-x(3)-[SGCL]-x-D-[LIVM]-D-
                         [LIVMFY](3)-x(2)-[SAP]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.31
            ExPASy - ENZYME nomenclature database: 2.7.7.31
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.31
            BRENDA, the Enzyme Database: 2.7.7.31
///
ENTRY       EC 2.7.7.32
NAME        Galactose-1-phosphate thymidylyltransferase
            dTDPgalactose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase
REACTION    dTTP + alpha-D-Galactose 1-phosphate = Pyrophosphate +
            dTDPgalactose
SUBSTRATE   dTTP
            alpha-D-Galactose 1-phosphate
PRODUCT     Pyrophosphate
            dTDPgalactose
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.32
            ExPASy - ENZYME nomenclature database: 2.7.7.32
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.32
            BRENDA, the Enzyme Database: 2.7.7.32
///
ENTRY       EC 2.7.7.33
NAME        Glucose-1-phosphate cytidylyltransferase
            CDPglucose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:D-glucose-1-phosphate cytidylyltransferase
REACTION    CTP + D-Glucose 1-phosphate = Pyrophosphate + CDPglucose
SUBSTRATE   CTP
            D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            CDPglucose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       YPE: YPO3115(ddhA)
            SME: SMb21058 SMb21059 SMb21416(ddhA)
            BSU: BG12979(yfnH)
            SYN: slr0983(rfbF)
            AFU: AF1142(rfbF)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.33
            ExPASy - ENZYME nomenclature database: 2.7.7.33
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.33
            BRENDA, the Enzyme Database: 2.7.7.33
///
ENTRY       EC 2.7.7.34
NAME        Glucose-1-phosphate guanylyltransferase
            GDPglucose pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:alpha-D-glucose-1-phosphate guanylyltransferase
REACTION    GTP + alpha-D-Glucose 1-phosphate = Pyrophosphate + GDPglucose
SUBSTRATE   GTP
            alpha-D-Glucose 1-phosphate
PRODUCT     Pyrophosphate
            GDPglucose
COMMENT     Also acts, more slowly, on D-mannose 1-phosphate.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.34
            ExPASy - ENZYME nomenclature database: 2.7.7.34
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.34
            BRENDA, the Enzyme Database: 2.7.7.34
///
ENTRY       EC 2.7.7.35
NAME        Ribose-5-phosphate adenylyltransferase
            ADPribose phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ADP:D-ribose-5-phosphate adenylyltransferase
REACTION    ADP + D-Ribose 5-phosphate = Orthophosphate + ADPribose
SUBSTRATE   ADP
            D-Ribose 5-phosphate
PRODUCT     Orthophosphate
            ADPribose
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.35
            ExPASy - ENZYME nomenclature database: 2.7.7.35
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.35
            BRENDA, the Enzyme Database: 2.7.7.35
///
ENTRY       EC 2.7.7.36
NAME        Aldose-1-phosphate adenylyltransferase
            Sugar-1-phosphate adenylyltransferase
            ADPaldose phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ADP:aldose-1-phosphate adenylyltransferase
REACTION    ADP + Aldose 1-phosphate = Orthophosphate + ADPaldose
SUBSTRATE   ADP
            Aldose 1-phosphate
PRODUCT     Orthophosphate
            ADPaldose
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.36
            ExPASy - ENZYME nomenclature database: 2.7.7.36
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.36
            BRENDA, the Enzyme Database: 2.7.7.36
///
ENTRY       EC 2.7.7.37
NAME        Aldose-1-phosphate nucleotidyltransferase
            Sugar-1-phosphate nucleotidyltransferase
            NDPaldose phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     NDP:aldose-1-phosphate nucleotidyltransferase
REACTION    NDP + Aldose 1-phosphate = Orthophosphate + NDPaldose
SUBSTRATE   NDP
            Aldose 1-phosphate
PRODUCT     Orthophosphate
            NDPaldose
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.37
            ExPASy - ENZYME nomenclature database: 2.7.7.37
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.37
            BRENDA, the Enzyme Database: 2.7.7.37
///
ENTRY       EC 2.7.7.38
NAME        3-Deoxy-manno-octulosonate cytidylyltransferase
            CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase
REACTION    CTP + 3-Deoxy-D-manno-octulosonate = Pyrophosphate +
            CMP-3-deoxy-D-manno-octulosonate
SUBSTRATE   CTP
            3-Deoxy-D-manno-octulosonate
PRODUCT     Pyrophosphate
            CMP-3-deoxy-D-manno-octulosonate
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b0918(kdsB)
            ECE: Z1264(kdsB)
            ECS: ECs1001
            YPE: YPO1400(kdsB)
            HIN: HI0058(kdsB)
            PMU: PM0858(kdsB)
            XFA: XF2299
            VCH: VC1875
            PAE: PA2979(kdsB)
            NME: NMB0675
            NMA: NMA0875(kdsB)
            HPY: HP0230(kdsB)
            HPJ: jhp0215
            CJE: Cj0813(kdsB)
            RPR: RP379(kdsB)
            RCO: RC0524(kdsB)
            MLO: mlr5497
            SME: SMb20803(kdsB2) SMc02898(kdsB)
            CCR: CC2934
            CTR: CT182
            CMU: TC0454
            CPN: CPn0235
            CPA: CP0527
            CPJ: kdsB
            AAE: aq_692(kpsU)
STRUCTURES  PDB: 1H6J  1H7F  1H7G  1H7H  1H7T  1H7E  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.38
            ExPASy - ENZYME nomenclature database: 2.7.7.38
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.38
            BRENDA, the Enzyme Database: 2.7.7.38
///
ENTRY       EC 2.7.7.39
NAME        Glycerol-3-phosphate cytidylyltransferase
            CDPglycerol pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:sn-glycerol-3-phosphate cytidylyltransferase
REACTION    CTP + sn-Glycerol 3-phosphate = Pyrophosphate + CDPglycerol
SUBSTRATE   CTP
            sn-Glycerol 3-phosphate
PRODUCT     Pyrophosphate
            CDPglycerol
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       BSU: BG10449(tagD)
            SAU: SA0597(tagD)
            SAV: SAV0629(tagD)
            LLA: L150584(tagD2) L19816(tagD1)
            AAE: aq_1368(tagD2) aq_185(tagD1)
            MJA: MJ1179(taqD)
            MTH: MTH844
            AFU: AF1418(taqD)
            HAL: VNG0777G(taqD)
            TAC: Ta1139
            TVO: TVG1279046
            PHO: PH0735
            PAB: PAB1507
STRUCTURES  PDB: 1COZ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.39
            ExPASy - ENZYME nomenclature database: 2.7.7.39
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.39
            BRENDA, the Enzyme Database: 2.7.7.39
            SCOP (Structural Classification of Proteins): 2.7.7.39
///
ENTRY       EC 2.7.7.40
NAME        D-Ribitol-5-phosphate cytidylyltransferase
            CDPribitol pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:D-ribitol-5-phosphate cytidylyltransferase
REACTION    CTP + D-Ribitol 5-phosphate = Pyrophosphate + CDPribitol
SUBSTRATE   CTP
            D-Ribitol 5-phosphate
PRODUCT     Pyrophosphate
            CDPribitol
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.40
            ExPASy - ENZYME nomenclature database: 2.7.7.40
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.40
            BRENDA, the Enzyme Database: 2.7.7.40
///
ENTRY       EC 2.7.7.41
NAME        Phosphatidate cytidylyltransferase
            CDPdiglyceride pyrophosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:phosphatidate cytidyltransferase
REACTION    CTP + Phosphatidate = Pyrophosphate + CDPdiacylglycerol
SUBSTRATE   CTP
            Phosphatidate
PRODUCT     Pyrophosphate
            CDPdiacylglycerol
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b0175(cdsA)
            ECE: Z0186(cdsA)
            ECS: ECs0177
            YPE: YPO1050(cdsA) YPO2816(ynbB)
            HIN: HI0919(cdsA)
            PMU: PM1990(cdsA)
            XFA: XF1049
            VCH: VC2255
            PAE: PA2536 PA3651(cdsA)
            NME: NMB0185
            NMA: NMA0082(cdsA)
            HPY: HP0215(cdsA)
            HPJ: jhp0201
            CJE: Cj1347c(cdsA)
            RPR: RP424(cdsA)
            RCO: RC0589(cdsA)
            MLO: mll0639
            SME: SMc02096(cdsA)
            CCR: CC1918
            BSU: BG12575(cdsA)
            BHA: BH2422(cdsA)
            SAU: SA1104(cdsA)
            SAV: SAV1249(cdsA)
            LLA: L182799(cdsA)
            SPY: SPy1964(cdsA)
            SPN: SP0262
            SPR: spr0241(cdsA)
            CAC: CAC1792(cdsA)
            MGE: MG437(cdsA)
            MPN: E30_orf395(cdsA)
            MPU: MYPU_4740(cdsA)
            UUR: UU511(cdsA)
            MTU: Rv2881c(cdsA)
            MTC: MT2948
            MLE: ML1589
            CTR: CT451
            CMU: TC0736
            CPN: CPn0567
            CPA: CP0182
            CPJ: cdsA
            TPA: TP0602
            SYN: slr1369(cdsA)
            DRA: DR1509
            AAE: aq_1249(cds)
            TMA: TM1397
            SCE: YBR029C(CDS1)
            CEL: C33H5.18
            DME: CG7962
            HSA: 1040(CDS1)
MOTIF       PS: PS01315  S-x-[LIVMF]-K-R-x(4)-K-D-x-[GSA]-x(2)-[LIF]-[PG]-x-H-G-
                         G-[LIVMF]-x-D-R-[LIVMFT]-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.41
            ExPASy - ENZYME nomenclature database: 2.7.7.41
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.41
            BRENDA, the Enzyme Database: 2.7.7.41
///
ENTRY       EC 2.7.7.42
NAME        [Glutamate--ammonia-ligase] adenylyltransferase
            Glutamine-synthetase adenylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyltransferase
REACTION    ATP + [L-Glutamate:ammonia ligase (ADP-forming)] =
            Pyrophosphate +
            Adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]
SUBSTRATE   ATP
            [L-Glutamate:ammonia ligase (ADP-forming)]
PRODUCT     Pyrophosphate
            Adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]
GENES       ECO: b3053(glnE)
            ECE: Z4406(glnE)
            ECS: ECs3936
            YPE: YPO0653(glnE)
            HIN: HI0069(glnE)
            PMU: PM0375(glnE)
            VCH: VC2438
            PAE: PA5014(glnE)
            NME: NMB0224
            NMA: NMA0035(glnE)
            MLO: mlr7698
            SME: SMc02368(glnE)
            CCR: CC2753
            MTU: Rv2221c(glnE)
            MTC: MT2279
            MLE: ML1630(glnE)
            AAE: aq_1774(glnE)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.42
            ExPASy - ENZYME nomenclature database: 2.7.7.42
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.42
            BRENDA, the Enzyme Database: 2.7.7.42
///
ENTRY       EC 2.7.7.43
NAME        N-Acylneuraminate cytidylyltransferase
            CMPsialate pyrophosphorylase
            CMPsialate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:N-acylneuraminate cytidylyltransferase
REACTION    CTP + N-Acylneuraminate = Pyrophosphate +
            CMP-N-acylneuraminate
SUBSTRATE   CTP
            N-Acylneuraminate
PRODUCT     Pyrophosphate
            CMP-N-acylneuraminate
COMMENT     Acts on N-acetyl- and N-glycolyl- derivatives.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       HIN: HI1279(neua)
            PMU: PM0187(neuA)
            NME: NMB0069
            HPY: HP0326(neuA)
            CJE: Cj1143(neuA1) Cj1311(neuA2) Cj1331(ptmB)
            HSA: 22951(CMAS)
STRUCTURES  PDB: 1EZI  1EYR  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.43
            ExPASy - ENZYME nomenclature database: 2.7.7.43
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.43
            BRENDA, the Enzyme Database: 2.7.7.43
            SCOP (Structural Classification of Proteins): 2.7.7.43
///
ENTRY       EC 2.7.7.44
NAME        Glucuronate-1-phosphate uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
REACTION    UTP + 1-Phospho-alpha-D-glucuronate = Pyrophosphate +
            UDPglucuronate
SUBSTRATE   UTP
            1-Phospho-alpha-D-glucuronate
PRODUCT     Pyrophosphate
            UDPglucuronate
COMMENT     Also acts slowly with CTP.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.44
            ExPASy - ENZYME nomenclature database: 2.7.7.44
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.44
            BRENDA, the Enzyme Database: 2.7.7.44
///
ENTRY       EC 2.7.7.45
NAME        Guanosine-triphosphate guanylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:GTP guanylyltransferase
REACTION    2 GTP = Pyrophosphate + P1,P4-Bis(5'-guanosyl) tetraphosphate
SUBSTRATE   GTP
PRODUCT     Pyrophosphate
            P1,P4-Bis(5'-guanosyl) tetraphosphate
COMMENT     Also acts, more slowly, on GDP to form P1,P3-bis(5'-guanosyl)
            triphosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.45
            ExPASy - ENZYME nomenclature database: 2.7.7.45
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.45
            BRENDA, the Enzyme Database: 2.7.7.45
///
ENTRY       EC 2.7.7.46
NAME        Gentamicin 2''-nucleotidyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     NTP:gentamicin 2''-nucleotidyltransferase
REACTION    Nucleoside triphosphate + Gentamicin = Pyrophosphate +
            2''-Nucleotidylgentamicin
SUBSTRATE   Nucleoside triphosphate
            Gentamicin
            ATP
            dATP
            CTP
            ITP
            GTP
            Kanamycin
            Tobramycin
            Sisomicin
PRODUCT     Pyrophosphate
            2''-Nucleotidylgentamicin
            2''-Nucleotidylkanamycin
            2''-Nucleotidyltobramycin
            2''-Nucleotidylsisomicin
COMMENT     ATP, dATP, CTP, ITP and GTP can act as donors; kanamycin,
            tobramycin and sisomicin can also act as acceptors. The
            nucleotidyl residue is transferred to the 2-hydroxyl of
            the 3-amino-3-deoxy-D-glucose moiety in the antibiotic.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.46
            ExPASy - ENZYME nomenclature database: 2.7.7.46
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.46
            BRENDA, the Enzyme Database: 2.7.7.46
///
ENTRY       EC 2.7.7.47
NAME        Streptomycin 3''-adenylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:streptomycin 3''-adenylyltransferase
REACTION    ATP + Streptomycin = Pyrophosphate + 3''-Adenylylstreptomycin
SUBSTRATE   ATP
            Streptomycin
            Spectinomycin
PRODUCT     Pyrophosphate
            3''-Adenylylstreptomycin
            3''-Adenylylspectinomycin
COMMENT     Also acts on spectinomycin.
GENES       SAU: SA0049(ant(9)) SA0765(ant(9)) SA1481(ant(9)) SA1952(ant(9))
                 SA2385(ant(9))
            SAV: SAV0048(spc) SAV1640(spc)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.47
            ExPASy - ENZYME nomenclature database: 2.7.7.47
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.47
            BRENDA, the Enzyme Database: 2.7.7.47
///
ENTRY       EC 2.7.7.48
NAME        RNA-directed RNA polymerase
            RNA nucleotidyltransferase (RNA-directed)
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
REACTION    Nucleoside triphosphate + RNA(n) = Pyrophosphate + RNA(n+1)
SUBSTRATE   Nucleoside triphosphate
            RNA(n)
PRODUCT     Pyrophosphate
            RNA(n+1)
COMMENT     Catalyses RNA-template-directed extension of the 3'- end of an RNA
            strand by one nucleotide at a time. Can initiate a chain de novo.
            See also EC 2.7.7.6.
            (EC 2.7.7.6 DNA-directed RNA polymerase)
PATHWAY     PATH: MAP00230  Purine metabolism
MOTIF       PS: PS00028  C-x(2,4)-C-x(3)-[LIVMFYWC]-x(8)-H-x(3,5)-H
STRUCTURES  PDB: 1C2P  1EZJ  1HAV  1QUV  1RDR  1CSJ  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.48
            ExPASy - ENZYME nomenclature database: 2.7.7.48
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.48
            BRENDA, the Enzyme Database: 2.7.7.48
            SCOP (Structural Classification of Proteins): 2.7.7.48
///
ENTRY       EC 2.7.7.49
NAME        RNA-directed DNA polymerase
            DNA nucleotidyltransferase (RNA-directed)
            Reverse transcriptase
            Revertase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase
            (RNA-directed)
REACTION    Deoxynucleoside triphosphate + DNA(n) = Pyrophosphate + DNA(n+1)
SUBSTRATE   Deoxynucleoside triphosphate
            DNA(n)
PRODUCT     Pyrophosphate
            DNA(n+1)
COMMENT     Catalyses RNA-template-directed extension of the 3'- end of a DNA
            strand by one deoxynucleotide at a time. Cannot initiate a chain
            de novo. Requires an RNA or DNA primer. DNA can also serve as
            template.
            See also EC 2.7.7.7 (EC 2.7.7.7 DNA-directed DNA polymerase)
GENES       HSA: 79004(MGC2491)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1JLE  1RT5  1RT4  1RT3  1RT2  1RT1  1REV  1RDH  1QE1  1QAJ  
                 1QAI  1KLM  1JLQ  1JLG  1QS4  1JLF  1JLC  1JLB  1JLA  1JKH  
                 1IKY  1IKX  1IKW  1IKV  1I6J  1HYZ  1HYV  1HYS  1HVU  3HVT  
                 1RT6  1RTJ  1HNV  1HNI  1HMV  1HAR  1GNO  1GNN  1GNM  1FKP  
                 1FKO  1FK9  1EP4  1VRT  1DLO  1D0E  1C9R  1C1C  1C1B  1C1A  
                 1C0U  1C0T  1C0M  1BQN  1BQM  1BHL  1B9F  1B9D  1B92  1A5X  
                 1A5W  1A5V  1RT7  1RTD  1RTH  1RTI  1RVL  1RVN  1RVM  1RVO  
                 1UWB  1RVP  1RVQ  1RVR  1TVR  1HPZ  2HMI  1VRU  1VSK  1VSM  
                 1HQU  1HQE  1EET  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.49
            ExPASy - ENZYME nomenclature database: 2.7.7.49
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.49
            BRENDA, the Enzyme Database: 2.7.7.49
            SCOP (Structural Classification of Proteins): 2.7.7.49
///
ENTRY       EC 2.7.7.50
NAME        mRNA guanylyltransferase
            mRNA capping enzyme
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     GTP:mRNA guanylyltransferase
REACTION    GTP + (5')ppPur-mRNA = Pyrophosphate + G(5')pppPur-mRNA 
SUBSTRATE   GTP
            (5')ppPur-mRNA
            Poly(A)
            Poly(G)
PRODUCT     Pyrophosphate
            G(5')pppPur-mRNA
            m7G(5')pppAn
            m7G(5')pppGn
COMMENT     The enzyme can modify also synthetic poly(A) and poly(G) to
            form the structures m7G(5')pppAn and m7G(5')pppGn.  Product 
            G(5')pppPur-mRNA (mRNA containing a guanosine residue linked 5' 
            through three phosphates to the 5' position of the terminal 
            residue).
GENES       SCE: YGL130W(CEG1)
            SPO: CEG1(ceg1)
            CEL: C03D6.3(cel-1)
            HSA: 8732(RNGTT)
STRUCTURES  PDB: 1CKM  1CKN  1CKO  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.50
            ExPASy - ENZYME nomenclature database: 2.7.7.50
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.50
            BRENDA, the Enzyme Database: 2.7.7.50
            SCOP (Structural Classification of Proteins): 2.7.7.50
///
ENTRY       EC 2.7.7.51
NAME        Adenylylsulfate--ammonia adenylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     Adenylylsulfate:ammonia adenylyltransferase
REACTION    Adenylylsulfate + NH3 = Adenosine 5'-phosphoramidate + Sulfate
SUBSTRATE   Adenylylsulfate
            NH3
PRODUCT     Adenosine 5'-phosphoramidate
            Sulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.51
            ExPASy - ENZYME nomenclature database: 2.7.7.51
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.51
            BRENDA, the Enzyme Database: 2.7.7.51
///
ENTRY       EC 2.7.7.52
NAME        RNA uridylyltransferase
            Terminal uridylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     UTP:RNA uridylyltransferase
REACTION    UTP + RNA(n) = Pyrophosphate + RNA(n+1)
SUBSTRATE   UTP
            RNA(n)
PRODUCT     Pyrophosphate
            RNA(n+1)
COMMENT     The enzyme requires an oligoribonucleotide or polyribonucleotide
            with a free terminal 3'-OH as a primer.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.52
            ExPASy - ENZYME nomenclature database: 2.7.7.52
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.52
            BRENDA, the Enzyme Database: 2.7.7.52
///
ENTRY       EC 2.7.7.53
NAME        ATP adenylyltransferase
            Bis(5'-nucleosyl)-tetraphosphate phosphorylase
            $ (NDP-forming)
            Diadenosinetetraphosphate alphabeta-phosphorylase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ADP:ATP adenylyltransferase
REACTION    ADP + ATP = Orthophosphate + P1,P4-Bis(5'-adenosyl) tetraphosphate
SUBSTRATE   ADP
            ATP
            GTP
            Adenosine tetraphosphate
PRODUCT     Orthophosphate
            P1,P4-Bis(5'-adenosyl) tetraphosphate
            P1,P5-Bis(5'-adenosyl) pentaphosphate
COMMENT     GTP and adenosine tetraphosphate can also act as adenylyl
            acceptors.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       SCE: YCL050C(APA1) YDR530C(APA2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.53
            ExPASy - ENZYME nomenclature database: 2.7.7.53
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.53
            BRENDA, the Enzyme Database: 2.7.7.53
///
ENTRY       EC 2.7.7.54
NAME        Phenylalanine adenylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:L-phenylalanine adenylyltransferase
REACTION    ATP + L-Phenylalanine = Pyrophosphate + N-Adenylyl-L-phenylalanine
SUBSTRATE   ATP
            L-Phenylalanine
PRODUCT     Pyrophosphate
            N-Adenylyl-L-phenylalanine
COMMENT     Part of the system for biosynthesis of the alkaloid cyclopeptine
            in Penicillium cyclopium.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.54
            ExPASy - ENZYME nomenclature database: 2.7.7.54
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.54
            BRENDA, the Enzyme Database: 2.7.7.54
///
ENTRY       EC 2.7.7.55
NAME        Anthranilate adenylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:anthranilate N-adenylyltransferase
REACTION    ATP + Anthranilate = Pyrophosphate + N-Adenylylanthranilate
SUBSTRATE   ATP
            Anthranilate
PRODUCT     Pyrophosphate
            N-Adenylylanthranilate
COMMENT     Part of the system for biosynthesis of the alkaloid cyclopeptine
            in Penicillium cyclopium.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.55
            ExPASy - ENZYME nomenclature database: 2.7.7.55
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.55
            BRENDA, the Enzyme Database: 2.7.7.55
///
ENTRY       EC 2.7.7.56
NAME        tRNA nucleotidyltransferase
            Phosphate-dependent exonuclease
            RNase PH
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     tRNA:orthophosphate nucleotidyltransferase
REACTION    tRNA(n+1) + Orthophosphate = tRNA(n) + a Nucleoside diphosphate
SUBSTRATE   tRNA(n+1)
            Orthophosphate
PRODUCT     tRNA(n)
            Nucleoside diphosphate
COMMENT     Brings about the final exonucleolytic trimming of the 3'-terminus
            of tRNA precursors in Escherichia coli by a phosphorolysis,
            producing a mature 3'-terminus on tRNA and nucleoside diphosphate.
            Not identical with EC 2.7.7.8.
GENES       ECO: b3643(rph)
            ECE: Z5068(rph)
            ECS: ECs4518
            YPE: YPO0044(rph)
            HIN: HI0273(rph)
            PMU: PM1876(rph)
            XFA: XF1505
            VCH: VC0210
            PAE: PA5334(rph)
            NME: NMB1499
            NMA: NMA1702(rph)
            RPR: RP628(rph)
            RCO: RC0975(rph)
            MLO: mlr4622
            SME: SMc01144(rph)
            CCR: CC0152
            BSU: BG10357(rph)
            BHA: BH3068(rph)
            MTU: Rv1340(rphA)
            MTC: MT1381
            MLE: ML1174(rphA)
            DRA: DR1585
            AAE: aq_1545 aq_924(rnpH)
            MTH: MTH683
            AFU: AF0493(rph)
            TAC: Ta1293
            TVO: TVG0319949
            PHO: PH1549
            PAB: PAB0420(rph)
            APE: APE1447
            SSO: SSO0735(rph)
            STO: ST0443
            CEL: B0564.1
MOTIF       PS: PS01277  C-[DE]-[LIVM](2)-[NQ]-[GTA]-D-G-[SG]-x(2)-[TA]-A
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.56
            ExPASy - ENZYME nomenclature database: 2.7.7.56
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.56
            BRENDA, the Enzyme Database: 2.7.7.56
///
ENTRY       EC 2.7.7.57
NAME        N-Methylphosphoethanolamine cytidylyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     CTP:N-methylethanolamine-phosphate cytidylyltransferase
REACTION    CTP + N-Methylethanolamine phosphate = Pyrophosphate +
            CDP-N-methylethanolamine
SUBSTRATE   CTP
            N-Methylethanolamine phosphate
PRODUCT     Pyrophosphate
            CDP-N-methylethanolamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.57
            ExPASy - ENZYME nomenclature database: 2.7.7.57
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.57
            BRENDA, the Enzyme Database: 2.7.7.57
///
ENTRY       EC 2.7.7.58
NAME        (2,3-Dihydroxybenzoyl)adenylate synthase
            2,3-Dihydroxybenzoate--AMP ligase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
SYSNAME     ATP:2,3-dihydroxybenzoate adenylyltransferase
REACTION    ATP + 2,3-Dihydroxybenzoate = Pyrophosphate +
            (2,3-Dihydroxybenzoyl)adenylate
SUBSTRATE   ATP
            2,3-Dihydroxybenzoate
PRODUCT     Pyrophosphate
            (2,3-Dihydroxybenzoyl)adenylate
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.58
            ExPASy - ENZYME nomenclature database: 2.7.7.58
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.58
            BRENDA, the Enzyme Database: 2.7.7.58
///
ENTRY       EC 2.7.7.59
NAME        [Protein-PII] Uridylyltransferase
            PII Uridylyl-transferase
            Uridylyl removing enzyme
CLASS       Transferases
            Transferring phosphorus-containing groups
            Nucleotidyltransferases
REACTION    UTP + [Protein-PII] = Pyrophosphate + Uridylyl-[protein-PII]
SUBSTRATE   UTP
            [Protein-PII]
PRODUCT     Pyrophosphate
            Uridylyl-[protein-PII]
COMMENT     The enzyme uridylylates and de-uridylylates the small trimeric
            Protein-PII
GENES       ECO: b0167(glnD)
            ECE: Z0177(glnD)
            ECS: ECs0169
            YPE: YPO1042(glnD)
            HIN: HI1719(glnD)
            PMU: PM0460(glnD)
            VCH: VC2262
            PAE: PA3658(glnD)
            NME: NMB1203
            NMA: NMA1374(glnD)
            MLO: mll5321
            SME: SMc01124(glnD)
            CCR: CC0013
            MTU: Rv2918c(glnD)
            MTC: MT2986
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.7.59
            ExPASy - ENZYME nomenclature database: 2.7.7.59
            WIT (What Is There) Metabolic Reconstruction: 2.7.7.59
///
ENTRY       EC 2.7.8.1
NAME        Ethanolaminephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase
REACTION    CDPethanolamine + 1,2-Diacylglycerol = CMP +
            a Phosphatidylethanolamine
SUBSTRATE   CDPethanolamine
            1,2-Diacylglycerol
PRODUCT     CMP
            Phosphatidylethanolamine
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00570  Sphingophospholipid biosynthesis
GENES       SCE: YHR123W(EPT1)
            CEL: F22E10.5
MOTIF       PS: PS00379  D-G-x(2)-A-R-x(8)-G-x(3)-D-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.1
            ExPASy - ENZYME nomenclature database: 2.7.8.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.1
            BRENDA, the Enzyme Database: 2.7.8.1
///
ENTRY       EC 2.7.8.2
NAME        Diacylglycerol cholinephosphotransferase
            Phosphorylcholine--glyceride transferase
            Alkylacylglycerol cholinephosphotransferase
            1-Alkyl-2-acetylglycerol cholinephosphotransferase
            Cholinephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPcholine:1,2-diacylglycerol cholinephosphotransferase
REACTION    CDPcholine + 1,2-Diacylglycerol = CMP + a Phosphatidylcholine
SUBSTRATE   CDPcholine
            1,2-Diacylglycerol
            1-Alkyl-2-acylglycerol
PRODUCT     CMP
            Phosphatidylcholine
COMMENT     1-Alkyl-2-acylglycerol can act as acceptor;
            this activity was previously listed as EC 2.7.8.16.
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       TPA: TP0671
            SCE: YNL130C(CPT1)
MOTIF       PS: PS00379  D-G-x(2)-A-R-x(8)-G-x(3)-D-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.2
            ExPASy - ENZYME nomenclature database: 2.7.8.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.2
            BRENDA, the Enzyme Database: 2.7.8.2
///
ENTRY       EC 2.7.8.3
NAME        Ceramide cholinephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPcholine:N-acylsphingosine cholinephosphotransferase
REACTION    CDPcholine + N-Acylsphingosine = CMP + Sphingomyelin
SUBSTRATE   CDPcholine
            N-Acylsphingosine
PRODUCT     CMP
            Sphingomyelin
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.3
            ExPASy - ENZYME nomenclature database: 2.7.8.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.3
            BRENDA, the Enzyme Database: 2.7.8.3
///
ENTRY       EC 2.7.8.4
NAME        Serine-phosphoethanolamine synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPethanolamine:L-serine ethanolaminephosphotransferase
REACTION    CDPethanolamine + L-Serine = CMP + L-Serine-phosphoethanolamine
SUBSTRATE   CDPethanolamine
            L-Serine
PRODUCT     CMP
            L-Serine-phosphoethanolamine
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.4
            ExPASy - ENZYME nomenclature database: 2.7.8.4
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.4
            BRENDA, the Enzyme Database: 2.7.8.4
///
ENTRY       EC 2.7.8.5
NAME        CDPdiacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
            Glycerophosphate phosphatidyltransferase
            3-Phosphatidyl-1'-glycerol-3'-phosphate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPdiacylglycerol:sn-glycerol-3-phosphate
            3-phosphatidyltransferase
REACTION    CDPdiacylglycerol + sn-Glycerol 3-phosphate = CMP +
            3(3-sn-Phosphatidyl)-sn-glycerol 1-phosphate
SUBSTRATE   CDPdiacylglycerol
            sn-Glycerol 3-phosphate
PRODUCT     CMP
            3(3-sn-Phosphatidyl)-sn-glycerol 1-phosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b1912(pgsA)
            ECE: Z3000(pgsA)
            ECS: ECs2650
            YPE: YPO1867(pgsA)
            HIN: HI0123(pgsA)
            PMU: PM0856(pgsA)
            XFA: XF2310
            VCH: VC1215
            PAE: PA2584(pgsA)
            NME: NMB1588
            NMA: NMA1779(pgsA)
            HPY: HP1016(pgsA)
            HPJ: jhp0407
            CJE: Cj1067(pgsA)
            RPR: RP049(pgsA)
            RCO: RC0075(pgsA)
            MLO: mlr7913
            SME: SMc00601(pgsA)
            CCR: CC2908
            BSU: BG11373(pgsA)
            BHA: BH2386(pgsA)
            SAU: SA1126(pgsA)
            SAV: SAV1270(pgsA)
            LLA: L29672(pgsA)
            SPY: SPy2196(pgsA)
            SPN: SP2222
            SPR: spr2027(pgsA)
            CAC: CAC1814(pgsA) CAC3596(pgsA)
            MGE: MG114(pgsA)
            MPN: A65_orf227(pgsA)
            MPU: MYPU_1680(pgsA)
            UUR: UU364(psgA)
            MTU: Rv1822(pgsA2) Rv2612c(pgsA) Rv2746c(pgsA3)
            MTC: MT1870 MT2687 MT2817
            MLE: ML0454(pgsA) ML0979 ML2081(pgsA2)
            CTR: CT496 CT797
            CMU: TC0180 TC0783
            CPN: CPn0615 CPn0947
            CPA: CP0132 CP0912
            CPJ: pgsA_1 pgsA_2
            BBU: BB0721
            TPA: TP0256
            SYN: sll1522(pgsA)
            AAE: aq_1480 aq_2154(pgsA1) aq_958(pgsA2)
            TMA: TM1861
            MTH: MTH1691
            AFU: AF1143(pgsA-1) AF1744(pgsA-2)
            HAL: VNG1030G(pgsA)
            TAC: Ta0569
            TVO: TVG0612669
            PHO: PH0460
            PAB: PAB1041(pgsA)
            APE: APE1526
            SSO: SSO0556(pgsA)
            SCE: YDL142C(CRD1)
MOTIF       PS: PS00379  D-G-x(2)-A-R-x(8)-G-x(3)-D-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.5
            ExPASy - ENZYME nomenclature database: 2.7.8.5
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.5
            BRENDA, the Enzyme Database: 2.7.8.5
///
ENTRY       EC 2.7.8.6
NAME        Undecaprenyl-phosphate galactosephosphotransferase
            Poly(isoprenol)-phosphate galactosephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDPgalactose:undecaprenyl-phosphate galactosephosphotransferase
REACTION    UDPgalactose + Undecaprenyl phosphate = UMP +
            alpha-D-Galactosyl-diphosphoundecaprenol
SUBSTRATE   UDPgalactose
            Undecaprenyl phosphate
PRODUCT     UMP
            alpha-D-Galactosyl-diphosphoundecaprenol
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.6
            ExPASy - ENZYME nomenclature database: 2.7.8.6
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.6
            BRENDA, the Enzyme Database: 2.7.8.6
///
ENTRY       EC 2.7.8.7
NAME        Holo-[acyl-carrier protein] synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CoA:apo-[acyl-carrier-protein] pantetheinephosphotransferase
REACTION    CoA + Apo-[acyl-carrier protein] = Adenosine 3',5'-bisphosphate +
            Holo-[acyl-carrier protein]
SUBSTRATE   CoA
            Apo-[acyl-carrier protein]
PRODUCT     Adenosine 3',5'-bisphosphate
            Holo-[acyl-carrier protein]
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b2563(acpS)
            ECE: Z3844(acpS)
            ECS: ECs3429
            YPE: YPO2929(acpS)
            VCH: VC2457
            BUC: BU256(acpS)
            NME: NMB0452
            NMA: NMA2033(acpS)
            HPY: HP0808(acpS)
            HPJ: jhp0744
            CJE: Cj1409(acpS)
            RPR: RP577(acpS)
            RCO: RC0881(acpS)
            MLO: mlr7761
            SME: SMc02654(acpS)
            CCR: CC1558
            BSU: BG12089(acpS)
            BHA: BH0518
            SAU: SA1875(dpj)
            SAV: SAV2056(dpj)
            LLA: L61355(acpS)
            SPY: SPy1804(acpS)
            SPN: SP1699
            SPR: spr1541(acpS)
            CAC: CAC0489
            MGE: MG211.1
            MPN: H10_orf119
            MPU: MYPU_1130(acpS)
            MTU: Rv2523c(acpS)
            MTC: MT2599
            MLE: ML1192(acpS)
            CTR: CT100
            CMU: TC0376
            CPN: CPn0313
            CPA: CP0445
            CPJ: acpS
            BBU: BB0010
            TPA: TP0828
            DRA: DR0247
            AAE: aq_813(acpS)
            TMA: TM0692
            AFU: AF0033(acaA-1)
STRUCTURES  PDB: 1F7L  1F7T  1F80  1FTE  1FTF  1FTH  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.7
            ExPASy - ENZYME nomenclature database: 2.7.8.7
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.7
            BRENDA, the Enzyme Database: 2.7.8.7
///
ENTRY       EC 2.7.8.8
NAME        CDPdiacylglycerol--serine O-phosphatidyltransferase
            Phosphatidylserine synthase
            CDPdiglyceride--serine O-phosphatidyltransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPdiacylglycerol:L-serine 3-O-phosphatidyltransferase
REACTION    CDPdiacylglycerol + L-Serine = CMP + 3-O-sn-Phosphatidyl-L-serine
SUBSTRATE   CDPdiacylglycerol
            L-Serine
PRODUCT     CMP
            3-O-sn-Phosphatidyl-L-serine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b2585(pssA)
            ECE: Z3870(pssA)
            ECS: ECs3452
            YPE: YPO3273(pssA)
            HIN: HI0425(pssA)
            PMU: PM1856(pssA)
            XFA: XF0442
            VCH: VC0315
            PAE: PA4693(pssA)
            NME: NMB1318
            NMA: NMA1532(pss)
            HPY: HP1071(pssA)
            HPJ: jhp0354
            CJE: Cj1114c(pssA)
            RPR: RP242(pssA)
            RCO: RC0326(pssA)
            MLO: mlr7822
            SME: SMc00552(pssA)
            BSU: BG11012(pssA)
            BHA: BH1310(pssA)
            CAC: CAC0676(pssA)
            MTU: Rv0436c(pssA)
            MTC: MT0452
            MLE: ML0310(pssA)
            CTR: CT826
            CMU: TC0213
            CPN: CPn0983
            CPA: CP0873
            CPJ: pssA
            BBU: BB0249
            MJA: MJ1212(pssA)
            MTH: MTH1027
            AFU: AF2044(pssA)
            HAL: VNG0784G(pssA)
            SCE: YCL004W(PGS1) YER026C(CHO1)
            SPO: SPCC1442.12(spcc1442.12)
            DME: CG7718
MOTIF       PS: PS00379  D-G-x(2)-A-R-x(8)-G-x(3)-D-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.8
            ExPASy - ENZYME nomenclature database: 2.7.8.8
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.8
            BRENDA, the Enzyme Database: 2.7.8.8
///
ENTRY       EC 2.7.8.9
NAME        Phosphomannan mannosephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     GDPmannose:phosphomannan mannosephosphotransferase
REACTION    GDPmannose + (Phosphomannan)n = GMP + (Phosphomannan)n+1
SUBSTRATE   GDPmannose
            (Phosphomannan)n
PRODUCT     GMP
            (Phosphomannan)n+1
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.9
            ExPASy - ENZYME nomenclature database: 2.7.8.9
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.9
            BRENDA, the Enzyme Database: 2.7.8.9
///
ENTRY       EC 2.7.8.10
NAME        Sphingosine cholinephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPcholine:sphingosine cholinephosphotransferase
REACTION    CDPcholine + Sphingosine = CMP + Sphingosyl-phosphocholine
SUBSTRATE   CDPcholine
            Sphingosine
PRODUCT     CMP
            Sphingosyl-phosphocholine
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.10
            ExPASy - ENZYME nomenclature database: 2.7.8.10
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.10
            BRENDA, the Enzyme Database: 2.7.8.10
///
ENTRY       EC 2.7.8.11
NAME        CDPdiacylglycerol--inositol 3-phosphatidyltransferase
            CDPdiglyceride--inositol phosphatidyltransferase
            Phosphatidylinositol synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPdiacylglycerol:myo-inositol 3-phosphatidyltransferase
REACTION    CDPdiacylglycerol + myo-Inositol =
            CMP + Phosphatidyl-1D-myo-inositol
SUBSTRATE   CDPdiacylglycerol
            myo-Inositol
PRODUCT     CMP
            Phosphatidyl-1D-myo-inositol
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       SCE: YPR113W(PIS1)
            DME: CG9245
            HSA: 10423(CDIPT)
MOTIF       PS: PS00379  D-G-x(2)-A-R-x(8)-G-x(3)-D-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.11
            ExPASy - ENZYME nomenclature database: 2.7.8.11
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.11
            BRENDA, the Enzyme Database: 2.7.8.11
///
ENTRY       EC 2.7.8.12
NAME        CDPglycerol glycerophosphotransferase
            Teichoic-acid synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPglycerol:poly(glycerophosphate) glycerophosphotransferase
REACTION    CDPglycerol + (Glycerophosphate)n = CMP + (Glycerophosphate)n+1
SUBSTRATE   CDPglycerol
            (Glycerophosphate)n
PRODUCT     CMP
            (Glycerophosphate)n+1
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.12
            ExPASy - ENZYME nomenclature database: 2.7.8.12
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.12
            BRENDA, the Enzyme Database: 2.7.8.12
///
ENTRY       EC 2.7.8.13
NAME        Phospho-N-acetylmuramoyl-pentapeptide-transferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala):
            undecaprenyl-phosphate phospho-N-acetylmuranoyl-pentapeptide-
            transferase
REACTION    UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) +
            Undecaprenyl phosphate = UMP +
            MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-
            $undecaprenol
SUBSTRATE   UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
            Undecaprenyl phosphate
PRODUCT     UMP
            MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-
            $undecaprenol
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0087(mraY)
            ECE: Z0097(mraY)
            ECS: ECs0091
            YPE: YPO0552(mraY)
            HIN: HI1135(mraY)
            PMU: PM0139(mraY)
            XFA: XF0795
            VCH: VC2404
            PAE: PA4415(mraY)
            BUC: BU219(mraY)
            NME: NMB0418
            NMA: NMA2066(mraY)
            HPY: HP0493(mraY)
            HPJ: jhp0445
            CJE: Cj0433c(mraY)
            RPR: RP595(mraY1)
            RCO: RC0910(mraY1)
            MLO: mll1558
            SME: SMc01863(mraY)
            BSU: BG10224(mraY)
            BHA: BH2568(mraY)
            SAU: SA1025(mraY)
            SAV: SAV1169(mraY)
            LLA: L91444(mraY)
            SPY: SPy1662(mraY)
            SPN: SP0337
            SPR: spr0305(mraY)
            CAC: CAC2127(mraY)
            MTU: Rv2156c(murX)
            MTC: MT2215
            MLE: ML0911(mraY)
            CTR: CT757
            CMU: TC0138
            CPN: CPn0900
            CPA: CP0966
            CPJ: mraY
            BBU: BB0303(mraY)
            TPA: TP0345
            SYN: sll0657(mraY)
            DRA: DR1835
            AAE: aq_053(mraY)
            TMA: TM0235
            MTH: MTH735
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.13
            ExPASy - ENZYME nomenclature database: 2.7.8.13
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.13
            BRENDA, the Enzyme Database: 2.7.8.13
///
ENTRY       EC 2.7.8.14
NAME        CDPribitol ribitolphosphotransferase
            Teichoic-acid synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPribitol:poly(ribitol phosphate) ribitolphosphotransferase
REACTION    CDPribitol + (Ribitol phosphate)n = CMP + (Ribitol phosphate)n+1
SUBSTRATE   CDPribitol
            (Ribitol phosphate)n
PRODUCT     CMP
            (Ribitol phosphate)n+1
COMMENT     Formerly EC 2.4.1.55.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.14
            ExPASy - ENZYME nomenclature database: 2.7.8.14
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.14
            BRENDA, the Enzyme Database: 2.7.8.14
///
ENTRY       EC 2.7.8.15
NAME        UDP-N-acetylglucosamine--dolichyl-
            $phosphate N-acetylglucosaminephosphstransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDP-N-acetyl-D-glucosamine:dolichyl-phosphate
            N-acetyl-D-glucosamine phosphotransferase
REACTION    UDP-N-acetyl-D-glucosamine + Dolichyl phosphate =
            UMP + N-Acetyl-D-glucosaminyl-diphosphodolichol
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Dolichyl phosphate
PRODUCT     UMP
            N-Acetyl-D-glucosaminyl-diphosphodolichol
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       PHO: PH0348
            PAB: PAB1288
            SSO: SSO0060(gnptA)
            SCE: YBR243C(ALG7)
            SPO: GPT(gpt)
            HSA: 1798(DPAGT1)
DISEASE     MIM: 191350  UDP-GlcNAc:dolichyl-phosphate
                         N-acetylglucosaminephosphotransferase
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.15
            ExPASy - ENZYME nomenclature database: 2.7.8.15
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.15
            BRENDA, the Enzyme Database: 2.7.8.15
///
ENTRY       EC 2.7.8.16
NAME        Deleted entry
            1-Alkyl-2-acetylglycerol choline phosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
COMMENT     Deleted entry. Now included with EC 2.7.8.2.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.16
            ExPASy - ENZYME nomenclature database: 2.7.8.16
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.16
///
ENTRY       EC 2.7.8.17
NAME        UDP-N-acetylglucosamine--lysosomal-
            $enzyme N-acetylglucosaminephosphotransferase
            N-Acetylglucosaminylphosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDP-N-acetyl-D-glucosamine:lysosomal-enzyme
            N-acetylglucosaminephosphotransferase
REACTION    UDP-N-acetyl-D-glucosamine + Lysosomal-enzyme D-mannose =
            UMP + Lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
SUBSTRATE   UDP-N-acetyl-D-glucosamine
            Lysosomal-enzyme D-mannose
PRODUCT     UMP
            Lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose
COMMENT     Some other glycoproteins with high-mannose can act as
            acceptors, but much more slowly than lysosomal enzymes.
GENES       HSA: 2795(GNPTA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.17
            ExPASy - ENZYME nomenclature database: 2.7.8.17
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.17
            BRENDA, the Enzyme Database: 2.7.8.17
///
ENTRY       EC 2.7.8.18
NAME        UDPgalactose--UDP-N-acetylglucosamine
            $ galactosephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDPgalactose:UDP-N-acetyl-D-glucosamine
            $ galactosephosphotransferase
REACTION    UDPgalactose + UDP-N-acetyl-D-glucosamine = UMP +
            UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine
SUBSTRATE   UDPgalactose
            UDP-N-acetyl-D-glucosamine
PRODUCT     UMP
            UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine
COMMENT     N-Acetylglucosamine end-groups in glycoproteins can also act as
            acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.18
            ExPASy - ENZYME nomenclature database: 2.7.8.18
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.18
            BRENDA, the Enzyme Database: 2.7.8.18
///
ENTRY       EC 2.7.8.19
NAME        UDPglucose--glycoprotein glucosephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     UDPglucose:glycoprotein-D-mannose glucosephosphotransferase
REACTION    UDPglucose + Glycoprotein D-mannose = UMP +
            Glycoprotein 6-(D-glucose-1-phospho)-D-mannose
SUBSTRATE   UDPglucose
            Glycoprotein D-mannose
PRODUCT     UMP
            Glycoprotein 6-(D-glucose-1-phospho)-D-mannose
COMMENT     Penultimate mannose residues on oligo-mannose type glycoproteins
            can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.19
            ExPASy - ENZYME nomenclature database: 2.7.8.19
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.19
            BRENDA, the Enzyme Database: 2.7.8.19
///
ENTRY       EC 2.7.8.20
NAME        Phosphatidylglycerol--membrane-oligosaccharide
            $ glycerophosphotransferase
            Phosphoglycerol transferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     Phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose
            $ glycerophosphotransferase
REACTION    Phosphatidylglycerol + Membrane-derived-oligosaccharide D-glucose =
            1,2-Diacyl-sn-glycerol +
            Membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose
SUBSTRATE   Phosphatidylglycerol
            Membrane-derived-oligosaccharide D-glucose
PRODUCT     1,2-Diacyl-sn-glycerol
            Membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose
COMMENT     1,2-beta- and 1,6-beta-linked glucose residues in membrane
            polysaccharides and in synthetic glucosides can act as acceptors.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b4359(mdoB)
            ECE: Z5959(mdoB)
            ECS: ECs5319
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.20
            ExPASy - ENZYME nomenclature database: 2.7.8.20
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.20
            BRENDA, the Enzyme Database: 2.7.8.20
///
ENTRY       EC 2.7.8.21
NAME        Membrane-oligosaccharide glycerophosphotransferase
            Periplasmic phosphoglycerotransferase
            Phosphoglycerol cyclase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     Membrane-derived-oligosaccharide-6-(glycerophospho)-
            $D-glucose:membrane-derived-oligosaccharide-D-glucose
            $ glycerophosphotransferase
REACTION    Transfer of a glycerophospho group from one membrane-derived
            oligosaccharide to another
SUBSTRATE   Membrane-derived oligosaccharide
PRODUCT     Membrane-derived oligosaccharide
COMMENT     beta-Linked glucose residues in simple glucosides, such as
            gentiobiose, can act as acceptor, free cyclic 1,2-phosphoglycerol
            is formed.
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.21
            ExPASy - ENZYME nomenclature database: 2.7.8.21
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.21
            BRENDA, the Enzyme Database: 2.7.8.21
///
ENTRY       EC 2.7.8.22
NAME        1-Alkenyl-2-acylglycerol cholinephosphotransferase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
SYSNAME     CDPcholine:1-alkenyl-2-acylglycerol cholinephosphotransferase
REACTION    CDPcholine + 1-Alkenyl-2-acylglycerol = CMP + Plasmenylcholine
SUBSTRATE   CDPcholine
            1-Alkenyl-2-acylglycerol
PRODUCT     CMP
            Plasmenylcholine
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.22
            ExPASy - ENZYME nomenclature database: 2.7.8.22
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.22
            BRENDA, the Enzyme Database: 2.7.8.22
///
ENTRY       EC 2.7.8.23
NAME        Carboxyvinyl-carboxyphosphonate phosphorylmutase
            Carboxyphosphonoenolpyruvate phosphonomutase
            CPEP phosphonomutase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Transferases for other substituted phosphate groups
REACTION    1-Carboxyvinyl carboxyphosphonate =
            3-(Hydrohydroxyphosphoryl)pyruvate + CO2
SUBSTRATE   1-Carboxyvinyl carboxyphosphonate
PRODUCT     3-(Hydrohydroxyphosphoryl)pyruvate
            CO2
COMMENT     Catalyses the transfer and decarboxylation of the
            carboxy(hydroxy)phosphoryl group, HOOC-P(O)(OH)- (phosphoryl being
            a 3-valent group), in the formation of an unusual C-P bond that is
            involved in the biosynthesis of the antibiotic bialaphos.
GENES       ECO: b0331(prpB)
            ECE: Z0427(prpB)
            ECS: ECs0385
            XFA: XF1234
            VCH: VC1336
            PAE: PA0796(prpB)
            NME: NMB0430
            NMA: NMA2055(prpB)
            BSU: BG11720(yqiQ)
            BHA: BH3922
            TAC: Ta1227
            TVO: TVG0361650
            APE: APE0222
            SSO: SSO2587(prpB)
            ATH: At1g77060(F22K20.14)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.8.23
            ExPASy - ENZYME nomenclature database: 2.7.8.23
            WIT (What Is There) Metabolic Reconstruction: 2.7.8.23
///
ENTRY       EC 2.7.9.1
NAME        Pyruvate,orthophosphate dikinase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with paired acceptors
SYSNAME     ATP:pyruvate,orthophosphate phosphotransferase
REACTION    ATP + Pyruvate + Orthophosphate = AMP + Phosphoenolpyruvate +
            Pyrophosphate
SUBSTRATE   ATP
            Pyruvate
            Orthophosphate
PRODUCT     AMP
            Phosphoenolpyruvate
            Pyrophosphate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
GENES       RPR: RP492(ppdK)
            RCO: RC0783(ppdK)
            MLO: mlr7532
            SME: SMc00025(ppdK)
            CCR: CC1471
            MTU: Rv1127c(ppdK)
            MTC: MT1159
            MLE: ML0955(ppdK)
            TPA: TP0746
            TMA: TM0272
            TAC: Ta0886
            TVO: TVG1029756
            ATH: At4g15530(dl3805c)
MOTIF       PS: PS00370  G-[GA]-x-[STN]-x-H-[STA]-[STAV]-[LIVM](2)-[STAV]-[RG]
            PS: PS00742  [DEQSK]-x-[LIVMF]-S-[LIVMF]-G-[ST]-N-D-[LIVM]-x-Q-
                         [LIVMFYGT]-[STALIV]-[LIVMFY]-[GAS]-x(2)-R
STRUCTURES  PDB: 1DIK  1GGO  2DIK  
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.9.1
            ExPASy - ENZYME nomenclature database: 2.7.9.1
            WIT (What Is There) Metabolic Reconstruction: 2.7.9.1
            BRENDA, the Enzyme Database: 2.7.9.1
            SCOP (Structural Classification of Proteins): 2.7.9.1
///
ENTRY       EC 2.7.9.2
NAME        Pyruvate,water dikinase
            Phosphoenolpyruvate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with paired acceptors
SYSNAME     ATP:pyruvate,water phosphotransferase
REACTION    ATP + Pyruvate + H2O = AMP + Phosphoenolpyruvate +
            Orthophosphate
SUBSTRATE   ATP
            Pyruvate
            H2O
PRODUCT     AMP
            Phosphoenolpyruvate
            Orthophosphate
COFACTOR    Manganese
COMMENT     A manganese protein.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b1702(ppsA)
            ECE: Z2731(ppsA)
            ECS: ECs2409
            YPE: YPO2409(ppsA)
            XFA: XF1259
            VCH: VCA0987
            PAE: PA1770(ppsA)
            NME: NMB0618
            NMA: NMA0826(ppsA)
            HPY: HP0121(ppsA)
            HPJ: jhp0111
            BSU: BG12657(pps)
            CAC: CAC0534(pps)
            SYN: slr0301(ppsA)
            DRA: DR1727
            AAE: aq_2142(ppsA)
            MJA: MJ0542(ppsA)
            MTH: MTH1117 MTH1118 MTH460
            AFU: AF0710(ppsA)
            HAL: VNG0330G(ppsA)
            PHO: PH0092
            PAB: PAB0057(ppsA)
            APE: APE0026 APE0028 APE0650
            SSO: SSO0883(ppsA-1)
            STO: ST1235
            CEL: T21C9.6
MOTIF       PS: PS00370  G-[GA]-x-[STN]-x-H-[STA]-[STAV]-[LIVM](2)-[STAV]-[RG]
            PS: PS00742  [DEQSK]-x-[LIVMF]-S-[LIVMF]-G-[ST]-N-D-[LIVM]-x-Q-
                         [LIVMFYGT]-[STALIV]-[LIVMFY]-[GAS]-x(2)-R
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.9.2
            ExPASy - ENZYME nomenclature database: 2.7.9.2
            WIT (What Is There) Metabolic Reconstruction: 2.7.9.2
            BRENDA, the Enzyme Database: 2.7.9.2
///
ENTRY       EC 2.7.9.3
NAME        Selenide,water dikinase
            Selenidephosphate synthase
CLASS       Transferases
            Transferring phosphorus-containing groups
            Phosphotransferases with paired acceptors
REACTION    ATP + Selenide + H2O = AMP + Selenophosphate + Phosphate
SUBSTRATE   ATP
            Selenide
            H2O
PRODUCT     AMP
            Selenophosphate
            Phosphate
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
GENES       ECO: b1764(selD)
            ECE: Z2797(selD)
            ECS: ECs2470
            YPE: YPO2164(selD)
            HIN: HI0200(selD)
            PMU: PM0790(selD)
            PAE: PA1642(selD)
            CJE: Cj1504c(selD)
            SME: SMa0028(selD)
            AAE: aq_1030(selD)
            CEL: Y45F10A.4
            DME: CG5025(Sps2) CG8553(SelD)
            HSA: 22928(SPS2) 22929(SPS)
DBLINKS     IUBMB Enzyme Nomenclature: 2.7.9.3
            ExPASy - ENZYME nomenclature database: 2.7.9.3
            WIT (What Is There) Metabolic Reconstruction: 2.7.9.3
///
ENTRY       EC 2.8.1.1
NAME        Thiosulfate sulfurtransferase
            Thiosulfate cyanide transsulfurase
            Thiosulfate thiotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
SYSNAME     Thiosulfate:cyanide sulfurtranserase
REACTION    Thiosulfate + Hydrogen cyanide = Sulfite + Thiocyanate
SUBSTRATE   Thiosulfate
            Hydrogen cyanide
PRODUCT     Sulfite
            Thiocyanate
COMMENT     A few other sulfur compounds can act as donors.
GENES       ECO: b1757 b2521(sseA)
            ECE: Z2789 Z3788(sseA)
            ECS: ECs2463 ECs3387
            VCH: VCA0620
            PAE: PA1292 PA4956(rhdA)
            MLO: mlr0355
            SME: SMb21549(thtR) SMc01172(sseA)
            CCR: CC1425
            BHA: BH1708
            MTU: Rv0815c(cysA2) Rv2291(sseB) Rv3117(cysA3) Rv3283(sseA)
            MTC: MT0837 MT2348 MT3199
            MLE: ML0728(sseA) ML2198(cysA3)
            DRA: DR0217 DR2531
            AAE: aq_1076(rhdA1) aq_1799(rhdA2)
            MTH: MTH622
            HAL: VNG2393G(tssA)
            APE: APE2595
            SSO: SSO1019(cysA-1) SSO1817(cysA-2)
            SCE: YOR251C(YOR251C)
            SPO: SPCC4B3.01(spcc4b3.01)
            CEL: D2023.5 F11G11.9 H12D21.4
            MMU: 98852(Tst)
            HSA: 7263(TST)
MOTIF       PS: PS00380  [FY]-x(3)-H-[LIV]-P-G-A-x(2)-[LIVF]
            PS: PS00683  [AV]-x(2)-[FY]-[DEAP]-G-[GSA]-[WF]-x-E-[FYW]
STRUCTURES  PDB: 1BOH  1BOI  1DP2  1E0C  1ORB  1RHD  1RHS  2ORA  
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.1
            ExPASy - ENZYME nomenclature database: 2.8.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.1
            BRENDA, the Enzyme Database: 2.8.1.1
            SCOP (Structural Classification of Proteins): 2.8.1.1
///
ENTRY       EC 2.8.1.2
NAME        3-Mercaptopyruvate sulfurtransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
SYSNAME     3-Mercaptopyruvate:cyanide sulfurtransferase
REACTION    3-Mercaptopyruvate + Hydrogen cyanide = Pyruvate + Thiocyanate;
            Mercaptoethanol + Hydrogen cyanide = Ethanol + Thiocyanate
SUBSTRATE   3-Mercaptopyruvate
            Hydrogen cyanide
            Sulfite
            Sulfinate
            Mercaptoethanol
PRODUCT     Pyruvate
            Thiocyanate
COMMENT     Sulfite, sulfinates, mercaptoethanol and mercaptopyruvate can
            also act as acceptor.
PATHWAY     PATH: MAP00272  Cysteine metabolism
GENES       HSA: 4357(MPST)
MOTIF       PS: PS00380  [FY]-x(3)-H-[LIV]-P-G-A-x(2)-[LIVF]
            PS: PS00683  [AV]-x(2)-[FY]-[DEAP]-G-[GSA]-[WF]-x-E-[FYW]
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.2
            ExPASy - ENZYME nomenclature database: 2.8.1.2
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.2
            BRENDA, the Enzyme Database: 2.8.1.2
///
ENTRY       EC 2.8.1.3
NAME        Thiosulfate--thiol sulfurtransferase
            Glutathione-dependent thiosulfate reductase
            Sulfane reductase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
SYSNAME     Thiosulfate:thiol sulfurtransferase
REACTION    Thiosulfate + 2 Glutathione = Sulfite + Oxidized glutathione +
            Sulfide
SUBSTRATE   Thiosulfate
            Glutathione
PRODUCT     Sulfite
            Oxidized glutathione
COMMENT     The primary product is glutathione hydrodisulfide, which reacts
            with glutathione to give oxidized glutathione and sulfide.
            L-Cysteine can also act as acceptor.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.3
            ExPASy - ENZYME nomenclature database: 2.8.1.3
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.3
            BRENDA, the Enzyme Database: 2.8.1.3
///
ENTRY       EC 2.8.1.4
NAME        tRNA sulfurtransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
SYSNAME     L-Cysteine:tRNA sulfurtransferase
REACTION    L-Cysteine + 'Activated' tRNA = L-Serine +
            tRNA containing a thionucleotide
SUBSTRATE   L-Cysteine
            'Activated' tRNA
PRODUCT     L-Serine
            tRNA containing a thionucleotide
COMMENT     A group of enzymes transferring sulfur to various nucleotides in
            a tRNA chain, producing residues such as 4-thiouridylate. Wite
            some enzymes mercaptopyruvate can act as sulfur donor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.4
            ExPASy - ENZYME nomenclature database: 2.8.1.4
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.4
            BRENDA, the Enzyme Database: 2.8.1.4
///
ENTRY       EC 2.8.1.5
NAME        Thiosulfate--dithiol sulfurtransferase
            Thiosulfate reductase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
SYSNAME     Thiosulfate:dithioerythritol sulfurtransferase
REACTION    Thiosulfate + Dithioerythritol = Sulfite +
            Dithioerythritol disulfide + Sulfide
SUBSTRATE   Thiosulfate
            Dithioerythritol
PRODUCT     Sulfite
            Dithioerythritol disulfide
            Sulfide
COMMENT     The enzyme from Chlorella shows very little activity towards
            monothiols such as glutathione and cysteine (cf. EC 2.8.1.3).
            May be identical with EC 2.8.1.1.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.5
            ExPASy - ENZYME nomenclature database: 2.8.1.5
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.5
            BRENDA, the Enzyme Database: 2.8.1.5
///
ENTRY       EC 2.8.1.6
NAME        Biotin synthase
            Biotin synthetase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfurtransferases
REACTION    Dethiobiotin + Sulfur = Biotin
SUBSTRATE   Dethiobiotin
            Sulfur
PRODUCT     Biotin
COFACTOR    Iron-sulfur
COMMENT     The sulfur donor has been unidentified to date - it is not
            elemental sulfur or an iron-sulfur cluster.
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       ECO: b0775(bioB)
            ECE: Z0994(bioB)
            ECS: ECs0853
            YPE: YPO1151(bioB)
            HIN: HI1022(bioB)
            PMU: PM0379(bioB)
            XFA: XF0064
            VCH: VC1112
            PAE: PA0500(bioB)
            BUC: BU291(bioB)
            NME: NMB1146 NMB1184
            NMA: NMA1358(bioB)
            HPY: HP1406(bioB)
            HPJ: jhp1298
            CJE: Cj1685c(bioB)
            MLO: mll5831 mll6007 mll9100
            CCR: CC3521
            BSU: BG11525(bioB)
            BHA: BH1748(bioB)
            SAU: SA2213(bioB)
            SAV: SAV2409(bioB)
            SPR: spr0691(bioY)
            CAC: CAC0210(bioB) CAC1631
            MTU: Rv1589(bioB)
            MTC: MT1624
            MLE: ML1220(bioB)
            CPN: CPn1044
            CPA: CP0808
            CPJ: bioB
            SYN: slr1364(bioB)
            AAE: aq_975(bioB)
            TMA: TM1269
            MJA: MJ0785 MJ1296(bioB)
            MTH: MTH1143
            PAB: PAB2355(bioB-like)
            SSO: SSO1115(bioB)
            SCE: YGR286C(BIO2)
            SPO: BIO2(bio2)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.1.6
            ExPASy - ENZYME nomenclature database: 2.8.1.6
            WIT (What Is There) Metabolic Reconstruction: 2.8.1.6
///
ENTRY       EC 2.8.2.1
NAME        Aryl sulfotransferase
            Phenol sulfotransferase
            Sulfokinase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:phenol sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + a Phenol =
            Adenosine 3',5'-bisphosphate + an Aryl sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Phenol
PRODUCT     Adenosine 3',5'-bisphosphate
            Aryl sulfate
COMMENT     A number of aromatic compounds can act as acceptors.
            Organic hydroxylamines are not substrates (cf. EC 2.8.2.9).
PATHWAY     PATH: MAP00920  Sulfur metabolism
GENES       HSA: 6799(SULT1A2) 6817(SULT1A1) 6818(SULT1A3)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.1
            ExPASy - ENZYME nomenclature database: 2.8.2.1
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.1
            BRENDA, the Enzyme Database: 2.8.2.1
///
ENTRY       EC 2.8.2.2
NAME        Alcohol sulfotransferase
            Hydroxysteroid sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:alcohol sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + an Alcohol =
            Adenosine 3',5'-bisphosphate + an Alkyl sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Alcohol
            Primary alcohol
            Secondary alcohol
            Aliphatic alcohol
            Ascorbic acid
            Chloramphenicol
            Ephedrine
            Hydroxysteroid
PRODUCT     Adenosine 3',5'-bisphosphate
            Alkyl sulfate
COMMENT     Primary and secondary alcohols, including aliphatic alcohols,
            ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids,
            but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15).
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       SME: SMb21249
            HSA: 6822(SULT2A1)
STRUCTURES  PDB: 1EFH  
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.2
            ExPASy - ENZYME nomenclature database: 2.8.2.2
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.2
            BRENDA, the Enzyme Database: 2.8.2.2
            SCOP (Structural Classification of Proteins): 2.8.2.2
///
ENTRY       EC 2.8.2.3
NAME        Amine sulfotransferase
            Arylamine sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:amine N-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + an Amine =
            Adenosine 3',5'-bisphosphate + a Sulfamate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Amine
            Aniline
            2-Naphthylamine
            Cyclohexylamine
            Octylamine
PRODUCT     Adenosine 3',5'-bisphosphate
            Sulfamate
            Phenylamide sulfate
            2-Naphthylamide sulfate
            Cyclohexylamide sulfate
            Octylamide sulfate
COMMENT     A large number of primary and secondary amines can act as
            acceptors, including aniline, 2-naphthylamine, cyclohexylamine
            and octylamine.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.3
            ExPASy - ENZYME nomenclature database: 2.8.2.3
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.3
            BRENDA, the Enzyme Database: 2.8.2.3
///
ENTRY       EC 2.8.2.4
NAME        Estrone sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Estrone = Adenosine 3',5'-bisphosphate
            + Estrone 3-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Estrone
PRODUCT     Adenosine 3',5'-bisphosphate
            Estrone 3-sulfate
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       MMU: 98431(Ste)
            HSA: 6783(STE)
DISEASE     MIM: 600043  Sulfotransferase, estrogen-preferring
STRUCTURES  PDB: 1AQU  1AQY  1BO6  
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.4
            ExPASy - ENZYME nomenclature database: 2.8.2.4
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.4
            BRENDA, the Enzyme Database: 2.8.2.4
            SCOP (Structural Classification of Proteins): 2.8.2.4
///
ENTRY       EC 2.8.2.5
NAME        Chondroitin 4-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:chondroitin 4'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Chondroitin =
            Adenosine 3',5'-bisphosphate + Chondroitin 4'-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Chondroitin
PRODUCT     Adenosine 3',5'-bisphosphate
            Chondroitin 4'-sulfate
COMMENT     The sulfation takes place at the 4-position of
            N-acetylgalactosamine residues of chondroitin.
            Not identical with EC 2.8.2.17.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.5
            ExPASy - ENZYME nomenclature database: 2.8.2.5
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.5
            BRENDA, the Enzyme Database: 2.8.2.5
///
ENTRY       EC 2.8.2.6
NAME        Choline sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:choline sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Choline =
            Adenosine 3',5'-bisphosphate + Choline sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Choline
PRODUCT     Adenosine 3',5'-bisphosphate
            Choline sulfate
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.6
            ExPASy - ENZYME nomenclature database: 2.8.2.6
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.6
            BRENDA, the Enzyme Database: 2.8.2.6
///
ENTRY       EC 2.8.2.7
NAME        UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:UDP-N-acetyl-D-galactosamine-4-sulfate
            $ 6-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + UDP-N-acetyl-D-galactosamine
            $ 4-sulfate = Adenosine 3',5'-bisphosphate + UDP-N-acetyl-D-
            $galactosamine 4,6-bissulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            UDP-N-acetyl-D-galactosamine 4-sulfate
PRODUCT     Adenosine 3',5'-bisphosphate
            UDP-N-acetyl-D-galactosamine 4,6-bissulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.7
            ExPASy - ENZYME nomenclature database: 2.8.2.7
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.7
            BRENDA, the Enzyme Database: 2.8.2.7
///
ENTRY       EC 2.8.2.8
NAME        Desulfoheparin sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:N-desulfoheparin N-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + N-Desulfoheparin =
            Adenosine 3',5'-bisphosphate + Heparin
SUBSTRATE   3'-Phosphoadenylylsulfate
            N-Desulfoheparin
            Heparin sulfate
PRODUCT     Adenosine 3',5'-bisphosphate
            Heparin
COMMENT     The enzyme also catalyses the sulfation of heparin sulfate, and
            to much more limited extent, of chondroitin 4-sulfate and
            dermatan sulfate.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.8
            ExPASy - ENZYME nomenclature database: 2.8.2.8
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.8
            BRENDA, the Enzyme Database: 2.8.2.8
///
ENTRY       EC 2.8.2.9
NAME        Tyrosine-ester sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:L-tyrosine-methyl-ester sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + L-Tyrosine methyl ester =
            Adenosine 3',5'-bisphosphate + L-Tyrosine methyl ester 4-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            L-Tyrosine methyl ester
PRODUCT     Adenosine 3',5'-bisphosphate
            L-Tyrosine methyl ester 4-sulfate
COMMENT     Phenols and organic hydroxylamines can act as acceptors
            (cf. EC 2.8.2.1).
GENES       MMU: 102896(Stp1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.9
            ExPASy - ENZYME nomenclature database: 2.8.2.9
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.9
            BRENDA, the Enzyme Database: 2.8.2.9
///
ENTRY       EC 2.8.2.10
NAME        Renilla-luciferin sulfotransferase
            Luciferin sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:Renilla luciferin sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Renilla luciferin =
            Adenosine 3',5'-bisphosphate + Luciferyl sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Renilla luciferin
PRODUCT     Adenosine 3',5'-bisphosphate
            Luciferyl sulfate
COMMENT     The product may be identical with Watasenia luciferin.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.10
            ExPASy - ENZYME nomenclature database: 2.8.2.10
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.10
            BRENDA, the Enzyme Database: 2.8.2.10
///
ENTRY       EC 2.8.2.11
NAME        Galactosylceramide sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + a Galactosylceramide =
            Adenosine 3',5'-bisphosphate + Galactosylceramidesulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Galactosylceramide
            Lactosylceramide
PRODUCT     Adenosine 3',5'-bisphosphate
            Galactosylceramidesulfate
            Lactosylceramidesulfate
COMMENT     Also acts on lactosylceramide.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: 9514(CST)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.11
            ExPASy - ENZYME nomenclature database: 2.8.2.11
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.11
            BRENDA, the Enzyme Database: 2.8.2.11
///
ENTRY       EC 2.8.2.12
NAME        Heparitin sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:heparitin N-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Heparitin =
            Adenosine 3',5'-bisphosphate + N-Sulfoheparitin
SUBSTRATE   3'-Phosphoadenylylsulfate
            Heparitin
PRODUCT     Adenosine 3',5'-bisphosphate
            N-Sulfoheparitin
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.12
            ExPASy - ENZYME nomenclature database: 2.8.2.12
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.12
            BRENDA, the Enzyme Database: 2.8.2.12
///
ENTRY       EC 2.8.2.13
NAME        Psychosine sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:galactosylsphingosine sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Galactosylsphingosine =
            Adenosine 3',5'-bisphosphate + Psychosine sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Galactosylsphingosine
PRODUCT     Adenosine 3',5'-bisphosphate
            Psychosine sulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.13
            ExPASy - ENZYME nomenclature database: 2.8.2.13
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.13
            BRENDA, the Enzyme Database: 2.8.2.13
///
ENTRY       EC 2.8.2.14
NAME        Bile-salt sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:taurolithocholate sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Taurolithocholate =
            Adenosine 3',5'-bisphosphate + Taurolithocholate sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Taurolithocholate
PRODUCT     Adenosine 3',5'-bisphosphate
            Taurolithocholate sulfate
COMMENT     Both conjugated and unconjugated bile salts can act as acceptors.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.14
            ExPASy - ENZYME nomenclature database: 2.8.2.14
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.14
            BRENDA, the Enzyme Database: 2.8.2.14
///
ENTRY       EC 2.8.2.15
NAME        Steroid sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:phenolic-steroid sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + a Phenolic steroid =
            Adenosine 3',5'-bisphosphate + Steroid O-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Phenolic steroid
PRODUCT     Adenosine 3',5'-bisphosphate
            Steroid O-sulfate
COMMENT     Broad specificity resembling EC 2.8.2.2, but also acts on estrone.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.15
            ExPASy - ENZYME nomenclature database: 2.8.2.15
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.15
            BRENDA, the Enzyme Database: 2.8.2.15
///
ENTRY       EC 2.8.2.16
NAME        Thiol sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:thiol S-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + a Thiol =
            Adenosine 3',5'-bisphosphate + an S-Alkyl thiosulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Thiol
            Glutathione
            Dithioerythritol
            2,3-Mercaptopropanol
PRODUCT     Adenosine 3',5'-bisphosphate
            S-Alkyl thiosulfate
COMMENT     Also acts on dithiols; substrates include glutathione,
            dithioerythritol and 2,3-mercaptopropanol.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.16
            ExPASy - ENZYME nomenclature database: 2.8.2.16
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.16
            BRENDA, the Enzyme Database: 2.8.2.16
///
ENTRY       EC 2.8.2.17
NAME        Chondroitin 6-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:chondroitin 6'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Chondroitin =
            Adenosine 3',5'-bisphosphate + Chondroitin 6'-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Chondroitin
PRODUCT     Adenosine 3',5'-bisphosphate
            Chondroitin 6'-sulfate
COMMENT     The sulfation is at the 6-position of N-acetylgalactosamine
            residues of chondroitin. Not identical with EC 2.8.2.5.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.17
            ExPASy - ENZYME nomenclature database: 2.8.2.17
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.17
            BRENDA, the Enzyme Database: 2.8.2.17
///
ENTRY       EC 2.8.2.18
NAME        Cortisol sulfotransferase
            Glucocorticosteroid sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:cortisol 21-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Cortisol =
            Adenosine 3',5'-bisphosphate + Cortisol 21-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Cortisol
PRODUCT     Adenosine 3',5'-bisphosphate
            Cortisol 21-sulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.18
            ExPASy - ENZYME nomenclature database: 2.8.2.18
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.18
            BRENDA, the Enzyme Database: 2.8.2.18
///
ENTRY       EC 2.8.2.19
NAME        Triglucosylalkylacylglycerol sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol
            $ 6-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + alpha-D-Glucosyl-1,6-alpha-D-
            $glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol =
            Adenosine 3',5'-bisphosphate + 6-Sulfo-alpha-D-glucosyl-1,6-
            $alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-
            $acylglycerol
SUBSTRATE   3'-Phosphoadenylylsulfate
            alpha-D-Glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-
            $1,3-1-O-alkyl-2-O-acylglycerol
PRODUCT     Adenosine 3',5'-bisphosphate
            6-Sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-
            $glucosyl-1,3-1-O-alkyl-2-O-acylglycerol
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.19
            ExPASy - ENZYME nomenclature database: 2.8.2.19
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.19
            BRENDA, the Enzyme Database: 2.8.2.19
///
ENTRY       EC 2.8.2.20
NAME        Protein-tyrosine sulfotransferase
            Tyrosylprotein sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:protein-tyrosine O-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Protein tyrosine =
            Adenosine 3',5'-bisphosphate + Protein tyrosine-O-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Protein tyrosine
PRODUCT     Adenosine 3',5'-bisphosphate
            Protein tyrosine-O-sulfate
COMMENT     The tyrosine residues of some specific proteins of rat
            pheochromocytoma cells act as acceptors.
GENES       CEL: F42G9.8
            HSA: 8459(TPST2) 8460(TPST1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.20
            ExPASy - ENZYME nomenclature database: 2.8.2.20
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.20
            BRENDA, the Enzyme Database: 2.8.2.20
///
ENTRY       EC 2.8.2.21
NAME        Keratan sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:keratan 6'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Keratan =
            Adenosine 3',5'-bisphosphate + Keratan 6'-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Keratan
PRODUCT     Adenosine 3',5'-bisphosphate
            Keratan 6'-sulfate
COMMENT     Sulfation takes place at the 6-position of galactosyl and
            N-acetylglucosaminyl residues in keratan, a proteoglycan. Not
            identical with EC 2.8.2.5, 2.8.2.6 or 2.8.2.17.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.21
            ExPASy - ENZYME nomenclature database: 2.8.2.21
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.21
            BRENDA, the Enzyme Database: 2.8.2.21
///
ENTRY       EC 2.8.2.22
NAME        Arylsulfate sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     Arylsulfate:phenol sulfotransferase
REACTION    an Aryl sulfate + a Phenol = a Phenol + an Aryl sulfate
SUBSTRATE   Aryl sulfate
            Phenol
PRODUCT     Phenol
            Aryl sulfate
COMMENT     Hydroxyl groups of tyrosine residues in peptides such as
            angiotensin can act as acceptors. Does not act on
            3'-phosphoadenylylsulfate or adenosine 3',5'-bisphosphate.
GENES       CJE: Cj0866(ast)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.22
            ExPASy - ENZYME nomenclature database: 2.8.2.22
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.22
            BRENDA, the Enzyme Database: 2.8.2.22
///
ENTRY       EC 2.8.2.23
NAME        Heparin-glucosamine 3-O-sulfotransferase
            Glucosaminyl 3-O-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:heparin-glucosamine 3-O-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Heparin-glucosamine =
            Adenosine 3',5'-bisphosphate + Heparin-glucosamine 3-O-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Heparin-glucosamine
PRODUCT     Adenosine 3',5'-bisphosphate
            Heparin-glucosamine 3-O-sulfate
COMMENT     A specific glucosaminyl residue in the antithrombin-binding site
            of heparin, or in a pentasaccharide derived from that site, acts
            as sulfate-acceptor. The enzyme brings about the final stage in
            the biosynthesis of heparin.
GENES       HSA: 9953(HS3ST3B1) 9955(HS3ST3A1) 9956(HS3ST2) 9957(HS3ST1)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.23
            ExPASy - ENZYME nomenclature database: 2.8.2.23
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.23
            BRENDA, the Enzyme Database: 2.8.2.23
///
ENTRY       EC 2.8.2.24
NAME        Desulfoglucosinolate sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:desulfoglucosinolate sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Desulfoglucotropeolin =
            Adenosine 3',5'-bisphosphate + Glucotropeolin
SUBSTRATE   3'-Phosphoadenylylsulfate
            Desulfoglucotropeolin
PRODUCT     Adenosine 3',5'-bisphosphate
            Glucotropeolin
COMMENT     Involved with EC 2.4.1.195 in the biosynthesis of thioglycosides
            in cruciferous plants.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.24
            ExPASy - ENZYME nomenclature database: 2.8.2.24
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.24
            BRENDA, the Enzyme Database: 2.8.2.24
///
ENTRY       EC 2.8.2.25
NAME        Flavonol 3-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:quercetin 3-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Quercetin =
            Adenosine 3',5'-bisphosphate + Quercetin 3-sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Quercetin
PRODUCT     Adenosine 3',5'-bisphosphate
            Quercetin 3-sulfate
COMMENT     Also acts on some other flavonol aglycones.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.25
            ExPASy - ENZYME nomenclature database: 2.8.2.25
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.25
            BRENDA, the Enzyme Database: 2.8.2.25
///
ENTRY       EC 2.8.2.26
NAME        Quercetin-3-sulfate 3'-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:quercetin-3-sulfate 3'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Quercetin 3-sulfate =
            Adenosine 3',5'-bisphosphate + Quercetin 3,3'-bissulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Quercetin 3-sulfate
PRODUCT     Adenosine 3',5'-bisphosphate
            Quercetin 3,3'-bissulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.26
            ExPASy - ENZYME nomenclature database: 2.8.2.26
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.26
            BRENDA, the Enzyme Database: 2.8.2.26
///
ENTRY       EC 2.8.2.27
NAME        Quercetin-3-sulfate 4'-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:quercetin-3-sulfate 4'-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Quercetin 3-sulfate =
            Adenosine 3',5'-bisphosphate + Quercetin 3,4'-bissulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Quercetin 3-sulfate
PRODUCT     Adenosine 3',5'-bisphosphate
            Quercetin 3,4'-bissulfate
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.27
            ExPASy - ENZYME nomenclature database: 2.8.2.27
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.27
            BRENDA, the Enzyme Database: 2.8.2.27
///
ENTRY       EC 2.8.2.28
NAME        Quercetin-3,3'-bissulfate 7-sulfotransferase
CLASS       Transferases
            Transferring sulfur-containing groups
            Sulfotransferases
SYSNAME     3'-Phosphoadenylylsulfate:quercetin-3,3'-bissulfate
            $ 7-sulfotransferase
REACTION    3'-Phosphoadenylylsulfate + Quercetin 3,3'-bissulfate =
            Adenosine 3',5'-bisphosphate + Quercetin 3,3',7-trissulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            Quercetin 3,3'-bissulfate
            Quercetin 3,4'-bissulfate
PRODUCT     Adenosine 3',5'-bisphosphate
            Quercetin 3,3',7-trissulfate
            Quercetin 3,4',7-trissulfate
COMMENT     Quercetin 3,4'-bissulfate can also act as acceptor.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.2.28
            ExPASy - ENZYME nomenclature database: 2.8.2.28
            WIT (What Is There) Metabolic Reconstruction: 2.8.2.28
            BRENDA, the Enzyme Database: 2.8.2.28
///
ENTRY       EC 2.8.3.1
NAME        Propionate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acetyl-CoA:propanoate CoA-transferase
REACTION    Acetyl-CoA + Propanoate = Acetate + Propanoyl-CoA
SUBSTRATE   Acetyl-CoA
            Propanoate
            Butanoate
            Lactate
PRODUCT     Acetate
            Propanoyl-CoA
            Butanoyl-CoA
            Lactoyl-CoA
COMMENT     Butanoate and lactate can also act as acceptors.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00643  Styrene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.1
            ExPASy - ENZYME nomenclature database: 2.8.3.1
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.1
            UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.1
            BRENDA, the Enzyme Database: 2.8.3.1
///
ENTRY       EC 2.8.3.2
NAME        Oxalate CoA-transferase
            Succinyl--beta-ketoacyl-CoA transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Succinyl-CoA:oxalate CoA-transferase
REACTION    Succinyl-CoA + Oxalate = Succinate + Oxalyl-CoA
SUBSTRATE   Succinyl-CoA
            Oxalate
PRODUCT     Succinate
            Oxalyl-CoA
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.2
            ExPASy - ENZYME nomenclature database: 2.8.3.2
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.2
            BRENDA, the Enzyme Database: 2.8.3.2
///
ENTRY       EC 2.8.3.3
NAME        Malonate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acetyl-CoA:malonate CoA-transferase
REACTION    Acetyl-CoA + Malonate = Acetate + Malonyl-CoA
SUBSTRATE   Acetyl-CoA
            Malonate
PRODUCT     Acetate
            Malonyl-CoA
COMMENT     The enzyme from Pseudomonas ovalis also catalyses the reaction of
            EC 4.1.1.9.
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.3
            ExPASy - ENZYME nomenclature database: 2.8.3.3
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.3
            BRENDA, the Enzyme Database: 2.8.3.3
///
ENTRY       EC 2.8.3.4
NAME        Deleted entry
            Butyrate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.4
            ExPASy - ENZYME nomenclature database: 2.8.3.4
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.4
///
ENTRY       EC 2.8.3.5
NAME        3-Oxoacid CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Succinyl-CoA:3-oxo-acid CoA-transferase
REACTION    Succinyl-CoA + a 3-Oxo acid = Succinate + a 3-Oxoacyl-CoA
SUBSTRATE   Succinyl-CoA
            3-Oxo acid
            3-Oxopropanoate
            3-Oxopentanoate
            3-Oxo-4-methylpentanoate
            3-Oxohexanoate
            Malonyl-CoA
PRODUCT     Succinate
            3-Oxoacyl-CoA
COMMENT     Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate,
            3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors;
            malonyl-CoA can act instead of succinyl-CoA.
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00650  Butanoate metabolism
GENES       PAE: PA1999 PA2000
            HPY: HP0691(scoa) HP0692(scob)
            HPJ: jhp0636 jhp0637
            RCO: RC0906(scoB)
            BSU: BG11153(scoA) BG11154(scoB)
            MTU: Rv2503c(scoB) Rv2504c(scoA)
            MTC: MT2578 MT2579
            DRA: DRA0054 DRA0067 DRA0068
            CEL: C05C10.3
            DME: CG1140
            HSA: 5019(OXCT)
DISEASE     MIM: 245050  Succinyl CoA:3-oxoacid CoA transferase
MOTIF       PS: PS01273  [DN]-[GN]-x(2)-[LIVMFA](3)-G-G-F-x(3)-G-x-P
            PS: PS01274  [LF]-[HQ]-S-E-N-G-[LIVF](2)-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.5
            ExPASy - ENZYME nomenclature database: 2.8.3.5
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.5
            BRENDA, the Enzyme Database: 2.8.3.5
///
ENTRY       EC 2.8.3.6
NAME        3-Oxoadipate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Succinyl-CoA:3-oxoadipate CoA-transferase
REACTION    Succinyl-CoA + 3-Oxoadipate = Succinate + 3-Oxoadipyl-CoA
SUBSTRATE   Succinyl-CoA
            3-Oxoadipate
PRODUCT     Succinate
            3-Oxoadipyl-CoA
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       CCR: CC0206 CC0207 CC2405 CC2406
MOTIF       PS: PS01273  [DN]-[GN]-x(2)-[LIVMFA](3)-G-G-F-x(3)-G-x-P
            PS: PS01274  [LF]-[HQ]-S-E-N-G-[LIVF](2)-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.6
            ExPASy - ENZYME nomenclature database: 2.8.3.6
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.6
            BRENDA, the Enzyme Database: 2.8.3.6
///
ENTRY       EC 2.8.3.7
NAME        Succinate--citramalate CoA-transferase
            Itaconate CoA-transferase
            Citramalate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Succinyl-CoA:citramalate CoA-transferase
REACTION    Succinyl-CoA + Citramalate = Succinate + Citramalyl-CoA
SUBSTRATE   Succinyl-CoA
            Citramalate
            Itaconate
PRODUCT     Succinate
            Citramalyl-CoA
            Itaconyl-CoA
COMMENT     Itaconate can also act as acceptor.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.7
            ExPASy - ENZYME nomenclature database: 2.8.3.7
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.7
            BRENDA, the Enzyme Database: 2.8.3.7
///
ENTRY       EC 2.8.3.8
NAME        Acetate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acyl-CoA:acetate CoA-transferase
REACTION    Acyl-CoA + Acetate = a Fatty acid anion + Acetyl-CoA
SUBSTRATE   Acyl-CoA
            Acetate
            Butanoyl-CoA
            Pentanoyl-CoA
PRODUCT     Fatty acid anion
            Acetyl-CoA
            Butanoate
            Pentanoate
COMMENT     Acts on butanoyl-CoA and pentanoyl-CoA.
PATHWAY     PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b2221(atoD) b2222(atoA)
            HIN: HI0773(atoA) HI0774(atoD)
            SPY: SPy0141(atoD.2) SPy0142 SPy1638(atoD.1) SPy1639(atoA)
MOTIF       PS: PS01273  [DN]-[GN]-x(2)-[LIVMFA](3)-G-G-F-x(3)-G-x-P
            PS: PS01274  [LF]-[HQ]-S-E-N-G-[LIVF](2)-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.8
            ExPASy - ENZYME nomenclature database: 2.8.3.8
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.8
            UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.8
            BRENDA, the Enzyme Database: 2.8.3.8
///
ENTRY       EC 2.8.3.9
NAME        Butyrate--acetoacetate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Butanoyl-CoA:acetoacetate CoA-transferase
REACTION    Butanoyl-CoA + Acetoacetate = Butanoate + Acetoacetyl-CoA
SUBSTRATE   Butanoyl-CoA
            Acetoacetate
PRODUCT     Butanoate
            Acetoacetyl-CoA
COMMENT     Butanoate, acetoacetate, and their CoA thioesters are the
            preferred substrates, but the enzyme also acts, more slowly, on
            the derivatives of a number of C2 to C6 monocarboxylic acids.
MOTIF       PS: PS01273  [DN]-[GN]-x(2)-[LIVMFA](3)-G-G-F-x(3)-G-x-P
            PS: PS01274  [LF]-[HQ]-S-E-N-G-[LIVF](2)-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.9
            ExPASy - ENZYME nomenclature database: 2.8.3.9
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.9
            BRENDA, the Enzyme Database: 2.8.3.9
///
ENTRY       EC 2.8.3.10
NAME        Citrate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acetyl-CoA:citrate CoA-transferase
REACTION    Acetyl-CoA + Citrate = Acetate + (3S)-Citryl-CoA
SUBSTRATE   Acetyl-CoA
            Citrate
PRODUCT     Acetate
            (3S)-Citryl-CoA
COMMENT     The enzyme is a component of EC 4.1.3.6. Also catalyses the
            transfer of thioacyl carrier protein from its acetyl thioester to
            citrate.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.10
            ExPASy - ENZYME nomenclature database: 2.8.3.10
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.10
            BRENDA, the Enzyme Database: 2.8.3.10
///
ENTRY       EC 2.8.3.11
NAME        Citramalate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acetyl-CoA:citramalate CoA-transferase
REACTION    Acetyl-CoA + Citramalate = Acetate + (3S)-Citramalyl-CoA
SUBSTRATE   Acetyl-CoA
            Citramalate
PRODUCT     Acetate
            (3S)-Citramalyl-CoA
COMMENT     The enzyme is a component of EC 4.1.3.22. Also catalyses the
            transfer of thioacyl carrier protein from its acetyl thioester to
            citramalate.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.11
            ExPASy - ENZYME nomenclature database: 2.8.3.11
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.11
            BRENDA, the Enzyme Database: 2.8.3.11
///
ENTRY       EC 2.8.3.12
NAME        Glutaconate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     (E)-Glutaconate CoA-transferase
REACTION    Acetyl-CoA + (E)-Glutaconate = Acetate + Glutaconyl-1-CoA
SUBSTRATE   Acetyl-CoA
            (E)-Glutaconate
            Glutarate
            (R)-2-Hydroxyglutarate
            Propenoate
            Propanoate
PRODUCT     Acetate
            Glutaconyl-1-CoA
            Glutaryl-CoA
            2-Hydroxyglutaryl-CoA
            Propenoyl-CoA
            Propanoyl-CoA
COMMENT     Glutarate, (R)-2-hydroxyglutarate, propenoate and propanoate, but
            not (Z)-glutaconate, can also act as acceptors.
PATHWAY     PATH: MAP00643  Styrene degradation
            PATH: MAP00650  Butanoate metabolism
GENES       AFU: AF1199(gctA)
            SSO: SSO1083(gctA) SSO1085(gctB)
            STO: ST0822 ST0823
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.12
            ExPASy - ENZYME nomenclature database: 2.8.3.12
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.12
            UM-BBD (Biocatalysis/Biodegradation Database): 2.8.3.12
            BRENDA, the Enzyme Database: 2.8.3.12
///
ENTRY       EC 2.8.3.13
NAME        Succinate--hydroxymethylglutarate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase
REACTION    Succinyl-CoA + (S)-3-Hydroxy-3-methylglutarate = Succinate +
            (S)-3-Hydroxy-3-methylglutaryl-CoA
SUBSTRATE   Succinyl-CoA
            (S)-3-Hydroxy-3-methylglutarate
PRODUCT     Succinate
            (S)-3-Hydroxy-3-methylglutaryl-CoA
COMMENT     Malonyl-CoA can also act as donor, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.13
            ExPASy - ENZYME nomenclature database: 2.8.3.13
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.13
            BRENDA, the Enzyme Database: 2.8.3.13
///
ENTRY       EC 2.8.3.14
NAME        5-Hydroxypentanoate CoA-transferase
            5-Hydroxyvalerate CoA-transferase
CLASS       Transferases
            Transferring sulfur-containing groups
            CoA-transferases
SYSNAME     Acetyl-CoA:5-hydroxypentanoate CoA-transferase
REACTION    Acetyl-CoA + 5-Hydroxypentanoate = Acetate +
            5-Hydroxypentanoyl-CoA
SUBSTRATE   Acetyl-CoA
            5-Hydroxypentanoate
PRODUCT     Acetate
            5-Hydroxypentanoyl-CoA
COMMENT     Propanoyl-CoA, acetyl-CoA, butanoyl-CoA and some other acyl-CoAs
            can act as substrates, more slowly than 5-hydroxypentanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 2.8.3.14
            ExPASy - ENZYME nomenclature database: 2.8.3.14
            WIT (What Is There) Metabolic Reconstruction: 2.8.3.14
            BRENDA, the Enzyme Database: 2.8.3.14
///
ENTRY       EC 2.9.1.1
NAME        L-Seryl-tRNA(Ser) seleniumtransferase
            Selenocysteinyl-tRNA(Ser) synthase
            Selenocysteine synthase
CLASS       Transferases
            Transferring other groups
            Seleniumtransferases
SYSNAME     L-Seryl-tRNA(Ser):selenophosphate seleniumtransferase
REACTION    L-Seryl-tRNA(Ser) + Selenophosphate = L-Selenocysteinyl-tRNA(Ser) +
            H2O + Orthophosphate
SUBSTRATE   L-Seryl-tRNA(Ser)
            Selenophosphate
PRODUCT     L-Selenocysteinyl-tRNA(Ser)
            H2O
            Orthophosphate
COFACTOR    Pyridoxal phosphate
COMMENT     2-Aminoacryloyl-tRNA bound to the enzyne as an imine with the
            pyridoxal phosphate, is an intermediate in the reaction.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
GENES       ECO: b3591(selA)
            ECE: Z5012(selA)
            ECS: ECs4468
            YPE: YPO4054(selA)
            HIN: HI0708(selA)
            PMU: PM1768(selA)
            PAE: PA4808(selA)
            HPY: HP1513(selA)
            HPJ: jhp1406
            CJE: Cj1378(selA)
            MLO: mlr3804
            SME: SMa0011(selA)
            AAE: aq_1031(selA)
DBLINKS     IUBMB Enzyme Nomenclature: 2.9.1.1
            ExPASy - ENZYME nomenclature database: 2.9.1.1
            WIT (What Is There) Metabolic Reconstruction: 2.9.1.1
///
ENTRY       EC 3.1.1.1
NAME        Carboxylesterase
            Ali-esterase
            B-esterase
            Monobutyrase
            Cocaine esterase
            Procaine esterase
            Methylbutyrase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Carboxylic-ester hydrolase
REACTION    a Carboxylic ester + H2O = an Alcohol + a Carboxylate
SUBSTRATE   Carboxylic ester
            H2O
            Vitamin A ester
PRODUCT     Alcohol
            Carboxylate
            Vitamin A
COMMENT     Wide specificity. The enzymes from microsomes also catalyse the
            reactions of EC 3.1.1.2, 3.1.1.5, 3.1.1.6, 3.1.1.23, 3.1.1.28,
            3.1.2.2, 3.5.1.4 and 3.5.1.13. Also hydrolyses vitamin A esters.
GENES       ECO: b0355(yaiM) b2154(yeiG)
            ECE: Z0455(yaiM) Z3410(yeiG)
            ECS: ECs0410 ECs3046
            YPE: YPO1501
            HIN: HI0184
            PAE: PA3628
            NME: NMB1305
            NMA: NMA1519(esd)
            MLO: mlr7099
            CCR: CC0799 CC2515
            BSU: BG11844(pnbA) BG11957(nap) BG12740(ybfK) BG14066(yvaK)
            BHA: BH3554
            SAU: SA0416 SA0734
            SAV: SAV0766
            MTU: Rv2045c(lipT)
            MTC: MT2105
            TPA: TP0902
            SYN: sll0992
            TMA: TM1022
            AFU: AF0865(est-1) AF1537(est-2) AF2336(est-3)
            SSO: SSO2517(est)
            SCE: YJL068C(YJL068C)
            CEL: F13H6.3 F13H6.4 F15A8.6 ges-1
            DME: CG17148(Est-P) CG4390 CG6917(Est-6)
            MMU: 95420(Es1) 95421(Es10) 95422(Es11) 95431(Es2) 95432(Es22)
                 95434(Es23-e) 95448(Es9)
            HSA: 1066(CES1) 2090(ESA4) 2097(ESB3) 2098(ESD)
DISEASE     MIM: 114835  Carboxylesterase 1 (monocyte/macrophage serine
                         esterase 1)
            MIM: 133280  Esterase D; S-formylglutathione hydrolase
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
            PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
STRUCTURES  PDB: 1AUO  1AUR  1EVQ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.1
            ExPASy - ENZYME nomenclature database: 3.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.1
            BRENDA, the Enzyme Database: 3.1.1.1
            SCOP (Structural Classification of Proteins): 3.1.1.1
///
ENTRY       EC 3.1.1.2
NAME        Arylesterase
            A-esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Aryl-ester hydrolase
REACTION    a Phenyl acetate + H2O = a Phenol + Acetate
SUBSTRATE   Phenyl acetate
            H2O
PRODUCT     Phenol
            Acetate
COMMENT     Acts on many phenolic esters. The reactions of EC 3.1.8.1
            were previously attributed to this enzyme.
GENES       VCH: VCA0783
            SME: SMc01033
            MMU: 103295(Pon1) 106686(Pon3) 106687(Pon2) 95427(Es16)
            HSA: 5444(PON1) 5445(PON2)
MOTIF       PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.2
            ExPASy - ENZYME nomenclature database: 3.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.2
            BRENDA, the Enzyme Database: 3.1.1.2
///
ENTRY       EC 3.1.1.3
NAME        Triacylglycerol lipase
            Lipase
            Triglyceride lipase
            Tributyrase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Triacylglycerol acylhydrolase
REACTION    Triacylglycerol + H2O = Diacylglycerol + a Carboxylate;
            Diacylglycerol + H2O = Monoacylglycerol + a Carboxylate
SUBSTRATE   Triacylglycerol
            H2O
            Diacylglycerol
PRODUCT     Diacylglycerol
            Carboxylate
            Monoacylglycerol
COMMENT     The pancreatic enzyme acts only on an ester-water interface;
            the outer ester links are preferentially hydrolyzed.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       VCH: VCA0221
            PAE: PA2862(lip)
            BSU: BG10679(lipA) BG11951(lipB)
            SAU: SA0309(geh) SA2463(lip)
            SAV: SAV0310(geh) SAV2656
            UUR: UU021(lip3)
            SYN: sll1969(lipA)
            DRA: DR2078
            AFU: AF1763
            SCE: YDR058C(TGL2)
            SPO: SPCC1672.09(spcc1672.09)
            DME: CG7329 CG8823(Lip3)
            MMU: 88374(Cel)
            HSA: 1056(CEL) 3989(LIPB) 3990(LIPC) 5406(PNLIP) 5407(PNLIPRP1)
                 5408(PNLIPRP2) 8513(LIPF)
DISEASE     MIM: 114840  Carboxyl-ester lipase (bile-salt stimulated lipase)
            MIM: 151670  Lipase, hepatic
            MIM: 246600  Pancreatic lipase
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
            PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
            PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
            PS: PS01173  [LIVMF](2)-x-[LIVMF]-H-G-G-[SAG]-[FY]-x(3)-[STDN]-x(2)-
                         [ST]-H
            PS: PS01174  [LIVM]-x-[LIVMF]-[SA]-G-D-S-[CA]-G-[GA]-x-L-[CA]
STRUCTURES  PDB: 1TIB  1FFD  5TGL  5LIP  1AKN  1BU8  1CRL  1CUA  1CUB  1CUC  
                 1CUD  1CUE  1CUF  1CUG  1CUH  1CUI  1CUJ  1CUU  1CUV  1CUW  
                 1CUX  1CUY  1CUZ  1CVL  1DT3  1DT5  1DTE  1DU4  1EIN  1ETH  
                 1EX9  1F6W  1FFA  1FFB  1FFC  1FFE  1OIL  1GPL  1HLG  1HPL  
                 1HQD  1I6W  1JMY  1LBS  1LBT  1LGY  1LPA  1LPB  1LPM  1LPN  
                 1LPO  1LPP  1LPS  1QGE  1TIA  1RP1  1TAH  1TCA  1TCB  1TCC  
                 1TGL  1THG  4LIP  4TGL  1TIC  1TRH  2LIP  3LIP  3TGL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.3
            ExPASy - ENZYME nomenclature database: 3.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.3
            BRENDA, the Enzyme Database: 3.1.1.3
            SCOP (Structural Classification of Proteins): 3.1.1.3
///
ENTRY       EC 3.1.1.4
NAME        Prophospholipase A2
            Lecithinase A
            Phosphatidase
            Phosphatidolipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Phosphatidylcholine 2-acylhydrolase
REACTION    Phosphatidylcholine + H2O = 1-Acylglycerophosphocholine +
            a Carboxylate
SUBSTRATE   Phosphatidylcholine
            Phosphatidylethanolamine
            Choline plasmalogen
            Choline phosphatide
            H2O
PRODUCT     1-Acylglycerophosphocholine
            Carboxylate
INHIBITOR   1-Hexadecylthio-2-hexadecanoylamino-1,2-dideoxy-sn-glycero-3-
            $phosphocholine
            1-Hexadecylthio-1-deoxy-2-hexadecylphosphono-sn-glycero-3-
            $phosphocholine
            AACOCF3
COFACTOR    Calcium
COMMENT     Also acts on phosphatidylethanolamine, choline plasmalogen and
            phosphatides, removing the fatty acid attached to the 2-position.
            Requires Ca2+.
            Inhibited by AACOCF3 (trifluoromethyl ketone analogue of
            arachidonic acid (Biochemistry 32, 5935-5940, (1993)).
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
            PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 104642(Pla2g2a)
            HSA: 26279(PLA2G2D) 30814(PLA2G2E) 5319(PLA2G1B) 5320(PLA2G2A)
                 5322(PLA2G5) 8398(PLA2G6) 8399(PLA2G10)
DISEASE     MIM: 172410  Phospholipase A2, group IB, pancreas
            MIM: 172411  Phospholipase A2, group IIA, platelets, synovial fluid
            MIM: 601192  Phospholipase A2, group V
MOTIF       PS: PS00118  C-C-x(2)-H-x(2)-C
            PS: PS00119  [LIVMA]-C-{LIVMFYWPCST}-C-D-x(5)-C
            PS: PS50004  C2-domain profile
STRUCTURES  PDB: 1FXF  1C74  1PP2  1KVO  1KVW  5P2P  4P2P  4BP2  3P2P  3BP2  
                 2PHI  1A2A  1A3D  1A3F  1AE7  1AOK  1AYP  1B4W  1BBC  1BCI  
                 1BJJ  1BK9  1BP2  1BPQ  1BUN  1BVM  2NOT  1CEH  1CJY  1CL5  
                 1CLP  1DB4  1DB5  1DCY  1DPY  1FAZ  1FDK  1FE5  1FX9  2BPP  
                 1G4I  1GH4  1GOD  1IRB  1JIA  1VIP  1VAP  1KVX  1KVY  1MKS  
                 1MKT  1MKU  1MKV  1P2P  1PIR  1PIS  1POA  1POB  1POC  1POD  
                 1POE  1PPA  1PSH  1PSJ  1QLL  1RLW  1SFV  1SFW  1UNE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.4
            ExPASy - ENZYME nomenclature database: 3.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.4
            BRENDA, the Enzyme Database: 3.1.1.4
            SCOP (Structural Classification of Proteins): 3.1.1.4
///
ENTRY       EC 3.1.1.5
NAME        Lisophospholipase
            Lecithinase B
            Lysolecithinase
            Phospholipase B
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     2-Lysophosphatidylcholine acylhydrolase
REACTION    2-Lysophosphatidylcholine + H2O = Glycerophosphocholine +
            a Carboxylate
SUBSTRATE   2-Lysophosphatidylcholine
            H2O
PRODUCT     Glycerophosphocholine
            Carboxylate
PATHWAY     PATH: MAP00580  Phospholipid degradation
GENES       ECO: b3825(pldB)
            ECE: Z5346(pldB)
            ECS: ECs4755
            YPE: YPO3830(pldB)
            HIN: HI0645(pldB)
            PMU: PM1631(pldB)
            VCH: VC0135
            CCR: CC2253
            CAC: CAC2246
            SCE: YMR006C(PLB2) YMR008C(PLB1) YOL011W
            SPO: SPAC1786.02(spac1786.02) SPAC1A6.03C(spac1a6.03c)
                 SPAC1A6.04C(spac1a6.04c) SPAC977.09C(spac977.09c)
                 SPCC1450.09C(spcc1450.09c)
            HSA: 1178(CLC) 5321(PLA2G4A)
DISEASE     MIM: 153310  Charcot-Leyden crystal protein
            MIM: 600522  Phospholipase A2, group IVA, cytosolic
MOTIF       PS: PS00309  W-[GEK]-x-[EQ]-x-[KRE]-x(3,6)-[PCTF]-[LIVMF]-[NQEGSKV]-
                         x-[GH]-x(3)-[DENKHS]-[LIVMFC]
            PS: PS01098  [LIVMFYAG](4)-G-D-S-[LIVM]-x(1,2)-[TAG]-G
            PS: PS50004  C2-domain profile
STRUCTURES  PDB: 1QKQ  1LCL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.5
            ExPASy - ENZYME nomenclature database: 3.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.5
            BRENDA, the Enzyme Database: 3.1.1.5
            SCOP (Structural Classification of Proteins): 3.1.1.5
///
ENTRY       EC 3.1.1.6
NAME        Acetylesterase
            C-esterase (in animal tissues)
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acetic-ester acetylhydrolase
REACTION    an Acetic ester + H2O = an Alcohol + Acetate
SUBSTRATE   Acetic ester
            H2O
PRODUCT     Alcohol
            Acetate
GENES       MMU: 95428(Es17)
STRUCTURES  PDB: 2AXE  1G66  1BS9  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.6
            ExPASy - ENZYME nomenclature database: 3.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.6
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.6
            BRENDA, the Enzyme Database: 3.1.1.6
            SCOP (Structural Classification of Proteins): 3.1.1.6
///
ENTRY       EC 3.1.1.7
NAME        Acetylcholinesterase
            True cholinesterase
            Choline esterase I
            Cholinesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acetylcholine aectylhydrolase
REACTION    Acetylcholine + H2O = Choline + Acetate
SUBSTRATE   Acetylcholine
            Acetic ester
            H2O
PRODUCT     Choline
            Acetate
INHIBITOR   Tacrine
COMMENT     Acts on a variety of acetic esters; also catalyses
            transacetylations
            Inhibited by tacrine (Proc.Natl.Acad.Sci.USA 90,9031-9035 (1993)).
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       CEL: ace-1
            DME: CG17907(Ace)
            HSA: 43(ACHE)
DISEASE     MIM: 100740  Acetylcholinesterase (YT blood group)
MOTIF       PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
STRUCTURES  PDB: 2ACE  2ACK  2CLJ  2DFP  3ACE  1VXR  1VXO  1VOT  1SOM  1QTI  
                 1QON  1QO9  1QIM  4ACE  1QII  1E66  1E3Q  1QIH  1QIK  1QIJ  
                 1ACJ  1ACL  1AMN  1AX9  1B41  1C2B  1C2O  1CFJ  1DX4  1DX6  
                 1EA5  1MAA  1EEA  1EVE  1F8U  1FSS  1HBJ  1MAH  1OCE  1QID  
                 1QIE  1QIF  1QIG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.7
            ExPASy - ENZYME nomenclature database: 3.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.7
            BRENDA, the Enzyme Database: 3.1.1.7
            SCOP (Structural Classification of Proteins): 3.1.1.7
///
ENTRY       EC 3.1.1.8
NAME        Cholinesterase
            Pseudocholinesterase
            Butrylcholine esterase
            Non-specific cholinesterase
            Choline esterase II (unspecific)
            Benzoylcholinesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acylcholine acylhydrolase
REACTION    an Acylcholine + H2O = Choline + a Carboxylate
SUBSTRATE   Acylcholine
            Choline ester
            H2O
PRODUCT     Choline
            Carboxylate
COMMENT     Acts on a variety of choline esters and a few other compounds.
GENES       HSA: 590(BCHE)
DISEASE     MIM: 177400  Butyrylcholinesterase
MOTIF       PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
STRUCTURES  PDB: 1EHO  1EHQ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.8
            ExPASy - ENZYME nomenclature database: 3.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.8
            BRENDA, the Enzyme Database: 3.1.1.8
///
ENTRY       EC 3.1.1.9
NAME        Deleted entry
            Benzoylcholinesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
COMMENT     Deleted entry. A side reaction of EC 3.1.1.8.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.9
            ExPASy - ENZYME nomenclature database: 3.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.9
///
ENTRY       EC 3.1.1.10
NAME        Tropinesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Atropine acylhydrolase
REACTION    Atropine + H2O = Tropine + Tropate
SUBSTRATE   Atropine
            Cocaine
            H2O
            Tropine ester
PRODUCT     Tropine
            Tropate
COMMENT     Also acts on cocaine and other tropine esters.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.10
            ExPASy - ENZYME nomenclature database: 3.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.10
            BRENDA, the Enzyme Database: 3.1.1.10
///
ENTRY       EC 3.1.1.11
NAME        Pectinesterase
            Pectin demethoxylase
            Pectin methoxylase
            Pectin methylesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Pectin pectylhydrolase
REACTION    Pectin + n H2O = n Methanol + Pectate
SUBSTRATE   Pectin
            H2O
PRODUCT     Methanol
            Pectate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00500  Starch and sucrose metabolism
GENES       YPE: YPO0424
            ATH: At1g53830(T18A20.6) At1g53840(T18A20.7)
MOTIF       PS: PS00503  [IV]-x-G-[STAD]-[LIVT]-D-[FYI]-[IV]-[FSN]-G
            PS: PS00800  [GSTNP]-x(6)-[FYVHR]-[IVN]-[KEP]-x-G-[STIVKRQ]-Y-
                         [DNQKRMV]-[EP]-x(3)-[LIMVA]
STRUCTURES  PDB: 1QJV  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.11
            ExPASy - ENZYME nomenclature database: 3.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.11
            BRENDA, the Enzyme Database: 3.1.1.11
            SCOP (Structural Classification of Proteins): 3.1.1.11
///
ENTRY       EC 3.1.1.12
NAME        Deleted entry
            Vitamin A esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
COMMENT     Deleted entry. Now believed to be identical with EC 3.1.1.1.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.12
            ExPASy - ENZYME nomenclature database: 3.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.12
///
ENTRY       EC 3.1.1.13
NAME        Sterol esterase
            Cholesterol esterase
            Cholesteryl ester synthase
            Triterpenol esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Steryl-ester acylhydrolase
REACTION    a Steryl ester + H2O = a Sterol + a Fatty acid
SUBSTRATE   Steryl ester
            H2O
PRODUCT     Sterol
            Fatty acid
COMMENT     A group of enzymes of broad specificity, acting on esters of
            sterols and long-chain fatty acids, which may also bring about the
            esterification of sterols. Activated by bile salts.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
GENES       MMU: 88374(Cel)
            HSA: 1056(CEL) 3988(LIPA)
DISEASE     MIM: 278000  Lipase A, lysosomal acid, cholesterol esterase
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
            PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
STRUCTURES  PDB: 2BCE  1AQL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.13
            ExPASy - ENZYME nomenclature database: 3.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.13
            BRENDA, the Enzyme Database: 3.1.1.13
            SCOP (Structural Classification of Proteins): 3.1.1.13
///
ENTRY       EC 3.1.1.14
NAME        Chlorophyllase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Chlorophyll chlorophyllidohydrolase
REACTION    Chlorophyll + H2O = Phytol + Chlorophyllide
SUBSTRATE   Chlorophyll
            H2O
PRODUCT     Phytol
            Chlorophyllide
COMMENT     Also catalyses chlorophyllide transfer, e.g. converts chlorophyll
            to methylchlorophyllide.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.14
            ExPASy - ENZYME nomenclature database: 3.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.14
            BRENDA, the Enzyme Database: 3.1.1.14
///
ENTRY       EC 3.1.1.15
NAME        L-Arabinonolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     L-Arabinono-1,4-lactone lactonohydrolase
REACTION    L-Arabinono-1,4-lactone + H2O = L-Arabinonate
SUBSTRATE   L-Arabinono-1,4-lactone
            H2O
PRODUCT     L-Arabinonate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.15
            ExPASy - ENZYME nomenclature database: 3.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.15
            BRENDA, the Enzyme Database: 3.1.1.15
///
ENTRY       EC 3.1.1.16
NAME        Deleted entry
            4-Carboxymethyl-4-hydroxyisocrotonolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
COMMENT     Deleted entry. This reaction was due to a mixture of
            muconolactone delta-isomerase (EC 5.3.3.4) and
            3-oxoadipate enol-lactonase (EC 3.1.1.24).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.16
            ExPASy - ENZYME nomenclature database: 3.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.16
///
ENTRY       EC 3.1.1.17
NAME        Gluconolactonase
            Lactonase
            Aldonolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     D-Glucono-1,5-lactone lactonohydrolase
REACTION    D-Glucono-1,5-lactone + H2O = D-Gluconate
SUBSTRATE   D-Glucono-1,5-lactone
            H2O
            L-Gulono-1,5-lactone
            Hexose-1,5-lactone
PRODUCT     D-Gluconate
            L-Gulonate
            Hexose
COMMENT     Acts on a wide range of hexose-1,5-lactones. The hydrolysis of
            L-gulono-1,5-lactone was previously listed as EC 3.1.1.18.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00053  Ascorbate and aldarate metabolism
            PATH: MAP00930  Caprolactam degradation
GENES       SME: SMa0196 SMb20453
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.17
            ExPASy - ENZYME nomenclature database: 3.1.1.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.17
            BRENDA, the Enzyme Database: 3.1.1.17
///
ENTRY       EC 3.1.1.18
NAME        Deleted entry
            Aldonolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
COMMENT     Deleted entry. Now included with EC 3.1.1.17.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.18
            ExPASy - ENZYME nomenclature database: 3.1.1.18
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.18
///
ENTRY       EC 3.1.1.19
NAME        Uronolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     D-Glucurono-6,2-lactone lactonohydrolase
REACTION    D-Glucurono-6,2-lactone + H2O = D-Glucuronate
SUBSTRATE   D-Glucurono-6,2-lactone
            H2O
PRODUCT     D-Glucuronate
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.19
            ExPASy - ENZYME nomenclature database: 3.1.1.19
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.19
            BRENDA, the Enzyme Database: 3.1.1.19
///
ENTRY       EC 3.1.1.20
NAME        Tannase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Tannin acylhydrolase
REACTION    Digallate + H2O = 2 Gallate
SUBSTRATE   Digallate
            H2O
PRODUCT     Gallate
COMMENT     Also hydrolyses ester links in other tannins.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.20
            ExPASy - ENZYME nomenclature database: 3.1.1.20
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.20
            BRENDA, the Enzyme Database: 3.1.1.20
///
ENTRY       EC 3.1.1.21
NAME        Retinyl-palmitate esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Retinyl-palmitate palmitohydrolase
REACTION    Retinyl palmitate + H2O = Retinol + Palmitate
SUBSTRATE   Retinyl palmitate
            H2O
PRODUCT     Retinol
            Palmitate
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.21
            ExPASy - ENZYME nomenclature database: 3.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.21
            BRENDA, the Enzyme Database: 3.1.1.21
///
ENTRY       EC 3.1.1.22
NAME        Hydroxybutyrate-dimer hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     (R)-3-((R)-3-Hydroxybutanoyloxy)-butanoate
            $ hydroxybutanoylhydrolase
REACTION    (R)-3-((R)-3-Hydroxybutanoyloxy)-butanoate + H2O =
            2 (R)-3-Hydroxybutanoate
SUBSTRATE   (R)-3-((R)-3-Hydroxybutanoyloxy)-butanoate
            H2O
PRODUCT     (R)-3-Hydroxybutanoate
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.22
            ExPASy - ENZYME nomenclature database: 3.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.22
            BRENDA, the Enzyme Database: 3.1.1.22
///
ENTRY       EC 3.1.1.23
NAME        Acylglycerol lipase
            Monoacylglycerol lipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Glycerol-ester acylhydrolase
REACTION    Hydrolyses glycerol monoesters of long-chain fatty acids
SUBSTRATE   Glycerol monoester
            H2O
PRODUCT     Glycerol
            Long-chain fatty acid
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.23
            ExPASy - ENZYME nomenclature database: 3.1.1.23
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.23
            BRENDA, the Enzyme Database: 3.1.1.23
///
ENTRY       EC 3.1.1.24
NAME        3-Oxoadipate enol-lactonase
            Carboxymethylbutenolide lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     4-Carboxymethylbut-3-en-4-olide enol-lactonohydrolase
REACTION    3-Oxoadipate enol-lactone + H2O = 3-Oxoadipate
SUBSTRATE   3-Oxoadipate enol-lactone
            H2O
PRODUCT     3-Oxoadipate
COMMENT     The enzyme acts on the product of EC 4.1.1.44.
            (EC 4.1.1.44 4-Carboxymuconolactone decarboxylase)
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       PAE: PA0231(pcaD) PA0480
            MLO: mll2481 mlr7206
            SME: SMb20579(pcaD)
            CCR: CC2411
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.24
            ExPASy - ENZYME nomenclature database: 3.1.1.24
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.24
            BRENDA, the Enzyme Database: 3.1.1.24
///
ENTRY       EC 3.1.1.25
NAME        1,4-Lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     1,4-Lactone hydroxyacylhydrolase
REACTION    a 1,4-Lactone + H2O = a 4-Hydroxyacid
SUBSTRATE   1,4-Lactone
            H2O
PRODUCT     4-Hydroxyacid
COFACTOR    Calcium
COMMENT     The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It
            does not hydrolyse simple aliphatic esters, acetylcholine, sugar
            lactones or substituted aliphatic lactones, e.g. 3-hydroxy-
            -4-butyrolactone; requires Ca2+.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.25
            ExPASy - ENZYME nomenclature database: 3.1.1.25
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.25
            BRENDA, the Enzyme Database: 3.1.1.25
///
ENTRY       EC 3.1.1.26
NAME        Galactolipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase
REACTION    1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O =
            3-beta-D-Galactosyl-sn-glycerol + 2 Carboxylate
SUBSTRATE   1,2-Diacyl-3-beta-D-galactosyl-sn-glycerol
            H2O
            2,3-Di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D-
            $galactosyl)-D-glycerol
            Phosphatidylcholine
PRODUCT     3-beta-D-Galactosyl-sn-glycerol
            Carboxylate
COMMENT     Also acts on 2,3-di-O-acyl-1-O-(6-O-alpha-D-galactosyl-beta-D-
            -galactosyl)-D-glycerol, and phosphatidylcholine and other
            phospholipids.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.26
            ExPASy - ENZYME nomenclature database: 3.1.1.26
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.26
            BRENDA, the Enzyme Database: 3.1.1.26
///
ENTRY       EC 3.1.1.27
NAME        4-Pyridoxolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     4-Pyridoxolactone lactonohydrolase
REACTION    4-Pyridoxolactone + H2O = 4-Pyridoxate
SUBSTRATE   4-Pyridoxolactone
            H2O
PRODUCT     4-Pyridoxate
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.27
            ExPASy - ENZYME nomenclature database: 3.1.1.27
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.27
            BRENDA, the Enzyme Database: 3.1.1.27
///
ENTRY       EC 3.1.1.28
NAME        Acylcarnitine hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     O-Acylcarnitine acylhydrolase
REACTION    O-Acylcarnitine + H2O = a Fatty acid + L-Carnitine
SUBSTRATE   O-Acylcarnitine
            H2O
            O-Decanoyl-L-carnitine
PRODUCT     Fatty acid
            L-Carnitine
            Decanoate
COMMENT     Acts on higher fatty acid (C6 to C18) esters of L-carnitine;
            highest activity is with O-decanoyl-L-carnitine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.28
            ExPASy - ENZYME nomenclature database: 3.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.28
            BRENDA, the Enzyme Database: 3.1.1.28
///
ENTRY       EC 3.1.1.29
NAME        Aminoacyl-tRNA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Aminoacyl-tRNA aminoacylhydrolase
REACTION    N-Substituted aminoacyl-tRNA + H2O = N-Substituted amino acid +
            tRNA
SUBSTRATE   N-Substituted aminoacyl-tRNA
            H2O
PRODUCT     N-Substituted amino acid
            tRNA
GENES       ECO: b1204(PTH)
            ECE: Z1975(pth)
            ECS: ECs1709
            YPE: YPO2011(pth)
            HIN: HI0394(PTH)
            PMU: PM0164(pth)
            XFA: XF2642
            VCH: VC2184
            PAE: PA4672
            BUC: BU190(pth)
            NME: NMB0795
            NMA: NMA1004(pth)
            HPY: HP1497(PTH)
            HPJ: jhp1390
            CJE: Cj0312(pth)
            RPR: RP605(pth)
            RCO: RC0931(pth)
            MLO: mlr2694
            SME: SMc02693(pth)
            CCR: CC0484
            BSU: BG10116(pth)
            BHA: BH0068(spoVC)
            SAU: SA0460(pth)
            SAV: SAV0490
            LLA: L0365(pth)
            SPY: SPy0007(pth)
            SPN: SP0005
            SPR: spr0005(pth)
            CAC: CAC3217(spoVC)
            MGE: MG083(PTH)
            MPN: G07_orf188(pth)
            MPU: MYPU_7810(pth)
            UUR: UU078(pth)
            MTU: Rv1014c(pth)
            MTC: MT1042
            MLE: ML0244(pth)
            CTR: CT800
            CMU: TC0183
            CPN: CPn0950
            CPA: CP0909
            CPJ: pth
            BBU: BB0787(pth)
            TPA: TP1011
            SYN: slr0922(PTH)
            DRA: DR2372
            AAE: aq_346(pth)
            TMA: TM1626
            SCE: YHR189W(YHR189W)
            SPO: SPBC2D10.15C(spbc2d10.15c)
MOTIF       PS: PS01195  [FY]-x(2)-T-[RK]-H-N-x-G-x(2)-[LIVMFA](2)-[DE]
            PS: PS01196  [GS]-x(3)-H-N-G-[LIVM]-[KR]-[DNS]-[LIVMTC]
STRUCTURES  PDB: 2PTH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.29
            ExPASy - ENZYME nomenclature database: 3.1.1.29
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.29
            BRENDA, the Enzyme Database: 3.1.1.29
            SCOP (Structural Classification of Proteins): 3.1.1.29
///
ENTRY       EC 3.1.1.30
NAME        D-Arabinonolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     D-Arabinono-1,4-lactone lactonohydrolase
REACTION    D-Arabinono-1,4-lactone + H2O = D-Arabinonate
SUBSTRATE   D-Arabinono-1,4-lactone
            H2O
PRODUCT     D-Arabinonate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.30
            ExPASy - ENZYME nomenclature database: 3.1.1.30
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.30
            BRENDA, the Enzyme Database: 3.1.1.30
///
ENTRY       EC 3.1.1.31
NAME        6-Phosphogluconolactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     6-Phospho-D-glucono-1,5-lactone lactonohydrolase
REACTION    D-Glucono-1,5-lactone 6-phosphate + H2O = 6-Phospho-D-gluconate
SUBSTRATE   D-Glucono-1,5-lactone 6-phosphate
            H2O
PRODUCT     6-Phospho-D-gluconate
COFACTOR    Magnesium
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       HIN: HI0556(devB)
            PMU: PM1550(devB)
            XFA: XF1063
            VCH: VCA0897
            PAE: PA3182
            NME: NMB1391
            NMA: NMA1608(pgl)
            HPY: HP1102(devB)
            HPJ: jhp1028
            MLO: mll6514
            SME: SMc03069(pgl)
            CCR: CC2056
            MTU: Rv1445c(devB)
            MTC: MT1492
            MLE: ML0579(pgl)
            CTR: CT186
            CMU: TC0458
            CPN: CPn0239
            CPA: CP0523
            CPJ: devB
            BBU: BB0222
            TPA: TP0477
            SYN: sll1479(devB)
            TMA: TM1154
            SCE: YGR248W(SOL4) YHR163W(SOL3)
            SPO: SPCC16C4.10(spcc16c4.10)
            CEL: Y57G11C.3
            DME: CG17333
            HSA: 25796(PGLS) 9563(H6PD)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.31
            ExPASy - ENZYME nomenclature database: 3.1.1.31
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.31
            BRENDA, the Enzyme Database: 3.1.1.31
///
ENTRY       EC 3.1.1.32
NAME        Phospholipase A1
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Phosphatidylcholine 1-acylhydrolase
REACTION    Phosphatidylcholine + H2O = 2-Acylglycerophosphocholine +
            a Carboxylate
SUBSTRATE   Phosphatidylcholine
            H2O
PRODUCT     2-Acylglycerophosphocholine
            Carboxylate
COFACTOR    Calcium
COMMENT     This enzyme has a much broader specificity than EC 3.1.1.4
            (EC 3.1.1.4 Phospholipase A2).
            Requires Ca2+.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
GENES       ECO: b3821(pldA)
            ECE: Z5342(pldA)
            ECS: ECs4751
            PMU: PM1426
            HPY: HP0499
            HPJ: jhp0451
            CJE: Cj1351(pldA)
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
STRUCTURES  PDB: 1ILZ  1FW2  1FW3  1ILD  1IM0  1QD5  1QD6  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.32
            ExPASy - ENZYME nomenclature database: 3.1.1.32
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.32
            BRENDA, the Enzyme Database: 3.1.1.32
            SCOP (Structural Classification of Proteins): 3.1.1.32
///
ENTRY       EC 3.1.1.33
NAME        6-Acetylglucose deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     6-Acetyl-D-glucose acetylhydrolase
REACTION    6-Acetyl-D-glucose + H2O = D-Glucose + Acetate
SUBSTRATE   6-Acetyl-D-glucose
            H2O
PRODUCT     D-Glucose
            Acetate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.33
            ExPASy - ENZYME nomenclature database: 3.1.1.33
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.33
            BRENDA, the Enzyme Database: 3.1.1.33
///
ENTRY       EC 3.1.1.34
NAME        Lipoprotein lipase
            Clearing factor lipase
            Diglyceride lipase
            Diacylglycerol lipase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Triglycero-protein acylhydrolase
REACTION    Triacylglycerol + H2O = Diacylglycerol + a Carboxylate
SUBSTRATE   Triacylglycerol
            H2O
PRODUCT     Diacylglycerol
            Carboxylate
COMMENT     Hydrolyses triacylglycerols in chylomicrons and low-density
            lipoproteins. Also hydrolyses diacylglycerol.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       HSA: 4023(LPL)
DISEASE     MIM: 238600  Lipoprotein lipase
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.34
            ExPASy - ENZYME nomenclature database: 3.1.1.34
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.34
            BRENDA, the Enzyme Database: 3.1.1.34
///
ENTRY       EC 3.1.1.35
NAME        Dihydrocoumarin hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Dihydrocoumarin lactonohydrolase
REACTION    Dihydrocoumarin + H2O = Melilotate
SUBSTRATE   Dihydrocoumarin
            H2O
PRODUCT     Melilotate
COMMENT     Also hydrolyses some other benzenoid 1,4-lactones.
PATHWAY     PATH: MAP00628  Fluorene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.35
            ExPASy - ENZYME nomenclature database: 3.1.1.35
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.35
            BRENDA, the Enzyme Database: 3.1.1.35
///
ENTRY       EC 3.1.1.36
NAME        Limonin-D-ring-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Limonoate-D-ring-lactone lactonohydrolase
REACTION    Limonoate D-ring-lactone + H2O = Limonoate
SUBSTRATE   Limonoate D-ring-lactone
            H2O
PRODUCT     Limonoate
COMMENT     Limonoate is a triterpenoid.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.36
            ExPASy - ENZYME nomenclature database: 3.1.1.36
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.36
            BRENDA, the Enzyme Database: 3.1.1.36
///
ENTRY       EC 3.1.1.37
NAME        Steroid-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Testololactone lactonohydrolase
REACTION    Testololactone + H2O = Testolate
SUBSTRATE   Testololactone
            H2O
PRODUCT     Testolate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.37
            ExPASy - ENZYME nomenclature database: 3.1.1.37
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.37
            BRENDA, the Enzyme Database: 3.1.1.37
///
ENTRY       EC 3.1.1.38
NAME        Triacetate-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Triacetolactone lactonohydrolase
REACTION    Triacetate lactone + H2O = Triacetate
SUBSTRATE   Triacetate lactone
            H2O
PRODUCT     Triacetate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.38
            ExPASy - ENZYME nomenclature database: 3.1.1.38
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.38
            BRENDA, the Enzyme Database: 3.1.1.38
///
ENTRY       EC 3.1.1.39
NAME        Actinomycin lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Actinomycin lactonohydrolase
REACTION    Actinomycin + H2O = Actinomycinic monolactone
SUBSTRATE   Actinomycin
            H2O
PRODUCT     Actinomycinic monolactone
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.39
            ExPASy - ENZYME nomenclature database: 3.1.1.39
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.39
            BRENDA, the Enzyme Database: 3.1.1.39
///
ENTRY       EC 3.1.1.40
NAME        Orsellinate-depside hydrolase
            Lecanorate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Orsellinate-depside hydrolase
REACTION    Orsellinate depside + H2O = 2 Orsellinate
SUBSTRATE   Orsellinate depside
            H2O
PRODUCT     Orsellinate
COMMENT     The enzyme will only hydrolyse those substrates based on the
            hydroxy ortho to depside linkage.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.40
            ExPASy - ENZYME nomenclature database: 3.1.1.40
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.40
            BRENDA, the Enzyme Database: 3.1.1.40
///
ENTRY       EC 3.1.1.41
NAME        Cephalosporin-C deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Cephalosporin-C acetylhdrolase
REACTION    Cephalosporin C + H2O = Deacetylcephalosporin C + Acetate
SUBSTRATE   Cephalosporin C
            H2O
PRODUCT     Deacetylcephalosporin C
            Acetate
COMMENT     Hydrosyses the acetyl estyl bond on the 10-position of the
            antibiotic cephalosporin C.
GENES       MLO: mlr6993
            BSU: BG11919(cah)
            BHA: BH3326
            SPN: SP1695
            TMA: TM0077
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.41
            ExPASy - ENZYME nomenclature database: 3.1.1.41
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.41
            BRENDA, the Enzyme Database: 3.1.1.41
///
ENTRY       EC 3.1.1.42
NAME        Chlorogenate hydrolase
            Chlorogenase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Chlorogenate hydroloase
REACTION    Chlorogenate + H2O = Caffeate + Quinate
SUBSTRATE   Chlorogenate
            H2O
PRODUCT     Calleate
            Quinate
COMMENT     Also acts, more slowly, on isochlorogenine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.42
            ExPASy - ENZYME nomenclature database: 3.1.1.42
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.42
            BRENDA, the Enzyme Database: 3.1.1.42
///
ENTRY       EC 3.1.1.43
NAME        alpha-Amino-acid esterase
            alpha-Amino-acid ester hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     alpha-Amino-acid-ester aminoacylhydrolase
REACTION    an alpha-Amino acid ester + H2O = an alpha-Amino acid + an Alcohol
SUBSTRATE   alpha-Amino acid ester
            H2O
PRODUCT     alpha-Amino acid
            Alcohol
COMMENT     Also catalyses alpha-aminoacyl transfer to am number of amine
            nucleophiles.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.43
            ExPASy - ENZYME nomenclature database: 3.1.1.43
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.43
            BRENDA, the Enzyme Database: 3.1.1.43
///
ENTRY       EC 3.1.1.44
NAME        4-Methyloxaloacetate esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Oxaloacetate-4-methyl-ester oxaloacetohydrolase
REACTION    Oxaloacetate 4-methyl ester + H2O = Oxaloacetate + Methanol
SUBSTRATE   Oxaloacetate 4-methyl ester
            H2O
PRODUCT     Oxaloacetate
            Methanol
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.44
            ExPASy - ENZYME nomenclature database: 3.1.1.44
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.44
            BRENDA, the Enzyme Database: 3.1.1.44
///
ENTRY       EC 3.1.1.45
NAME        Carboxymethylenebutenolidase
            Maleylacetate enol-lactonase
            Dienelactone hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     4-Carboxymethylenebut-2-en-4-olide lactonohydrolase
REACTION    4-Carboxymethylenebut-2-en-4-olide + H2O = 4-Oxohex-2-enedioate
SUBSTRATE   4-Carboxymethylenebut-2-en-4-olide
            H2O
PRODUCT     4-Oxohex-2-enedioate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00627  1,4-Dichlorobenzene degradation
GENES       YPE: YPO3787
            SME: SMc00817
            MTU: Rv2054
            MTC: MT2114
            MLE: ML1444
            SYN: sll1298(clcD)
            AAE: aq_1997
            SSO: SSO2087(clcD)
STRUCTURES  PDB: 1GGV  1DIN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.45
            ExPASy - ENZYME nomenclature database: 3.1.1.45
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.45
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.1.45
            BRENDA, the Enzyme Database: 3.1.1.45
            SCOP (Structural Classification of Proteins): 3.1.1.45
///
ENTRY       EC 3.1.1.46
NAME        Deoxylimonate A-ring-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Deoxylimonate A-ring-lactonohydrolase
REACTION    Deoxylimonate + H2O = Deoxylimononic acid D-ring-lactone
SUBSTRATE   Deoxylimonate
            H2O
PRODUCT     Deoxylimononic acid D-ring-lactone
COMMENT     The enzyme opens the A-ring-lactone of the triterpenoid
            deoxylimonic acid, leaving the D-ring-lactone intact.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.46
            ExPASy - ENZYME nomenclature database: 3.1.1.46
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.46
            BRENDA, the Enzyme Database: 3.1.1.46
///
ENTRY       EC 3.1.1.47
NAME        1-Alkyl-2-acetylglycerophosphocholine esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase
REACTION    1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O =
            1-Alkyl-sn-glycerol-3-phosphocholine + Acetate
SUBSTRATE   1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine
            H2O
PRODUCT     1-Alkyl-sn-glycerol-3-phosphocholine
            Acetate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       SPN: SP1450
            CEL: C52B9.7
            DME: CG8440(Lis1) CG8962(Paf-AHalpha)
            HSA: 4186(MDCR) 5048(PAFAH1B1) 5049(PAFAH1B2) 5050(PAFAH1B3)
                 5051(PAFAH2) 7941(PLA2G7)
DISEASE     MIM: 247200  Miller-Dieker syndrome chromosome region
            MIM: 601545  Platelet-activating factor acetylhydrolase, isoform
                         1B, alpha subunit
MOTIF       PS: PS00120  [LIV]-x-[LIVFY]-[LIVMST]-G-[HYWV]-S-x-G-[GSTAC]
            PS: PS00678  [LIVMSTAC]-[LIVMFYWSTAGC]-[LIMSTAG]-[LIVMSTAGC]-x(2)-
                         [DN]-x(2)-[LIVMWSTAC]-x-[LIVMFSTAG]-W-[DEN]-
                         [LIVMFSTAGCN]
STRUCTURES  PDB: 1BWP  1BWQ  1BWR  1ES9  1WAB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.47
            ExPASy - ENZYME nomenclature database: 3.1.1.47
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.47
            BRENDA, the Enzyme Database: 3.1.1.47
            SCOP (Structural Classification of Proteins): 3.1.1.47
///
ENTRY       EC 3.1.1.48
NAME        Fusarinine-C ornithinesterase
            Ornithine esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     N5-Acyl-L-ornithine-ester hydrolase
REACTION    N5-Acyl-L-ornithine ester + H2O = N5-Acyl-L-ornithine + an Alcohol
SUBSTRATE   N5-Acyl-L-ornithine ester
            H2O
            N5-Dinitrophenyl-L-ornithine methyl ester
PRODUCT     N5-Acyl-L-ornithine
            Alcohol
COMMENT     Hydrolyses the 3 ornithine ester bonds in fusarinine C. Also acts
            on N5-dinitrophenyl-L-ornithine methyl ester.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.48
            ExPASy - ENZYME nomenclature database: 3.1.1.48
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.48
            BRENDA, the Enzyme Database: 3.1.1.48
///
ENTRY       EC 3.1.1.49
NAME        Sinapine esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Sinapoylcholine sinapohydrolase
REACTION    Sinapoylcholine + H2O = Sinapate + Choline
SUBSTRATE   Sinapoylcholine
            H2O
PRODUCT     Sinapate
            Choline
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.49
            ExPASy - ENZYME nomenclature database: 3.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.49
            BRENDA, the Enzyme Database: 3.1.1.49
///
ENTRY       EC 3.1.1.50
NAME        Wax-ester hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Wax-ester acylhydrolase
REACTION    a Wax ester + H2O = a Long-chain alcohol +
            a Long-chain carboxylate
SUBSTRATE   Wax ester
            H2O
PRODUCT     Long-chain alcohol
            Long-chain carboxylate
COMMENT     Also acts on long-chain acylglycerol, but not deacyl- or
            triacyl- glycerols.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.50
            ExPASy - ENZYME nomenclature database: 3.1.1.50
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.50
            BRENDA, the Enzyme Database: 3.1.1.50
///
ENTRY       EC 3.1.1.51
NAME        Phorbol-diester hydrolase
            Diacylphorbate 12-hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     12,13-Diacylphorbate 12-acylhydrolase
REACTION    Phorbol 12,13-dibutanoate + H2O = Phorbol 13-butanoate + Butanoate
SUBSTRATE   Phorbol 12,13-dibutanoate
            H2O
PRODUCT     Phorbol 13-butanoate
            Butanoate
COMMENT     Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols
            (phorbol is a detetpenoid) this reaction inactivates tumour
            promoter 12-O-tetradecanoylphorbol-13-acetate from croton oil.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.51
            ExPASy - ENZYME nomenclature database: 3.1.1.51
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.51
            BRENDA, the Enzyme Database: 3.1.1.51
///
ENTRY       EC 3.1.1.52
NAME        Phosphatidylinositol deacylase
            Phosphatidylinositol phospholipase A2
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     1-Phosphatidyl-D-myo-inositol 2-acylhydrolase
REACTION    1-Phosphatidyl-D-myo-inositol + H2O =
            1-Acylglycerophosphoinositol + a Carboxylate
SUBSTRATE   1-Phosphatidyl-D-myo-inositol
            H2O
PRODUCT     1-Acylglycerophosphoinositol
            Carboxylate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.52
            ExPASy - ENZYME nomenclature database: 3.1.1.52
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.52
            BRENDA, the Enzyme Database: 3.1.1.52
///
ENTRY       EC 3.1.1.53
NAME        Sialate O-acetylesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     N-Acyl-O-acetylneuraminate O-acetylesterase
REACTION    N-Acyl-O-acetylneuraminate + H2O = N-Acetylneuraminate +
            Acetate
SUBSTRATE   N-Acyl-O-acetylneuraminate
            H2O
PRODUCT     N-Acetylneuraminate
            Acetate
COMMENT     Acts on free and glycosidically-bonded N-acetyl- or N-glycoloyl-
            neuraminic acid; acts mainly on 4-O- and 9-O-acetyl groups.  Also
            acts on some other O-acetyl esters, both cyclic and acyclic
            compounds, which are not sialic acids.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.53
            ExPASy - ENZYME nomenclature database: 3.1.1.53
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.53
            BRENDA, the Enzyme Database: 3.1.1.53
///
ENTRY       EC 3.1.1.54
NAME        Acetoxybutynylbithiophene deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     5-(4-Acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase
REACTION    5-(4-Acetoxybut-1-ynyl)-2,2'-bithiophene + H2O =
            5-(4-Hydroxybut-1-ynyl)-2,2'-bithiophene + Acetate
SUBSTRATE   5-(4-Acetoxybut-1-ynyl)-2,2'-bithiophene
            H2O
PRODUCT     5-(4-Hydroxybut-1-ynyl)-2,2'-bithiophene
            Acetate
COMMENT     The enzyme is highly specific.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.54
            ExPASy - ENZYME nomenclature database: 3.1.1.54
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.54
            BRENDA, the Enzyme Database: 3.1.1.54
///
ENTRY       EC 3.1.1.55
NAME        Acetylsalicylate deacetylase
            Aspirin esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Acetylsalicylate O-acetylhydrolase
REACTION    Acetylsalicylate + H2O = Salicylate + Acetate
SUBSTRATE   Acetylsalicylate
            H2O
PRODUCT     Salicylate
            Acetate
COMMENT     Not identical with EC 3.1.1.1, 3.1.1.2, 3.1.1.7 or 3.1.1.8.  The
            activity of the liver cytosol enzyme is highest with acetyl esters
            of aryl alcohols, and thioesters are also hydrolaysed; the
            microsomal enzyme also hydrolyses some other negatively charged
            esters, with highest activity on esters of salicylate with long-
            -chain alcohols.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.55
            ExPASy - ENZYME nomenclature database: 3.1.1.55
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.55
            BRENDA, the Enzyme Database: 3.1.1.55
///
ENTRY       EC 3.1.1.56
NAME        Methylumbelliferyl-acetate deacetylase
            Esterase D
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     4-Methylumbelliferyl-acetate acylhydrolase
REACTION    4-Methylumbelliferyl acetate + H2O = 4-Methylumbelliferone +
            Acetate
SUBSTRATE   4-Methylumbelliferyl acetate
            H2O
PRODUCT     4-Methylumbelliferone
            Acetate
COMMENT     Acts on short-chain acyl esters of 4-methylumbelliferone, but not
            on naphthyl, indoxyl or thiocholine esters.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.56
            ExPASy - ENZYME nomenclature database: 3.1.1.56
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.56
            BRENDA, the Enzyme Database: 3.1.1.56
///
ENTRY       EC 3.1.1.57
NAME        2-Pyrone-4,6-dicarboxylate lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     2-Pyrone-4,6-dicarboxylate lactonohydrolase
REACTION    2-Pyrone-4,6-dicarboxylate + H2O =
            4-Carboxy-2-hydroxyhexa-2,4-dienedioate
SUBSTRATE   2-Pyrone-4,6-dicarboxylate
            H2O
PRODUCT     4-Carboxy-2-hydroxyhexa-2,4-dienedioate
COMMENT     The product isomerizes to 4-oxalmesaconate.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.57
            ExPASy - ENZYME nomenclature database: 3.1.1.57
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.57
            BRENDA, the Enzyme Database: 3.1.1.57
///
ENTRY       EC 3.1.1.58
NAME        N-Acetylgalactosaminoglycan deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     N-Acetyl-D-galactosaminoglycan acetylhydrolase
REACTION    N-Acetyl-D-galactosaminoglycan + H2O = D-Galactosaminoglycan +
            Acetate
SUBSTRATE   N-Acetyl-D-galactosaminoglycan
            H2O
PRODUCT     D-Galactosaminoglycan
            Acetate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.58
            ExPASy - ENZYME nomenclature database: 3.1.1.58
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.58
            BRENDA, the Enzyme Database: 3.1.1.58
///
ENTRY       EC 3.1.1.59
NAME        Juvenile-hormone esterase
            JH-esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyl-trideca-
            $2,6-dienoate acylhydrolase
REACTION    Methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-
            $2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-Epoxy-3,7,11-
            $trimethyltrideca-2,6-dienoate + Methanol
SUBSTRATE   Methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-
            $2,6-dienoate
            H2O
PRODUCT     (2E,6E)-(10R,11S)-10,11-Epoxy-3,7,11-trimethyltrideca-2,6-
            $dienoate
            Methanol
COMMENT     Demethylates the insect juvenile hormones, JH1 and JH3, but
            does not hydrolyse the analogous ethyl or isopropyl esters.
GENES       DME: CG9858
MOTIF       PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.59
            ExPASy - ENZYME nomenclature database: 3.1.1.59
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.59
            BRENDA, the Enzyme Database: 3.1.1.59
///
ENTRY       EC 3.1.1.60
NAME        Bis(2-ethylhexyl)phthalate esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Bis(2-ethylhexyl)phthalate acylhydrolase
REACTION    Bis(2-ethylhexyl)phthalate + H2O = 2-Ethylhexyl phthalate +
            2-Ethylhexan-1-ol
SUBSTRATE   Bis(2-ethylhexyl)phthalate
            H2O
PRODUCT     2-Ethylhexyl phthalate
            2-Ethylhexan-1-ol
COMMENT     Also acts on 4-nitrophenyl esters, with optimum chin-length
            C6 to C8.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.60
            ExPASy - ENZYME nomenclature database: 3.1.1.60
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.60
            BRENDA, the Enzyme Database: 3.1.1.60
///
ENTRY       EC 3.1.1.61
NAME        Protein-glutamate methylesterase
            Chemotaxis-specific methylesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Protein-L-glutamate-O4-methyl-ester acylhydrolase
REACTION    Protein glutamate O4-methyl ester + H2O =
            Protein glutamate + Methanol
SUBSTRATE   Protein glutamate O4-methyl ester
            H2O
PRODUCT     Protein glutamate
            Methanol
COMMENT     Hydrolyses the products of EC 2.1.1.80 and 2.1.1.24.
GENES       ECO: b1883(cheB)
            ECE: Z2937(cheB)
            ECS: ECs2593
            YPE: YPO1679(cheB)
            VCH: VC2062
            PAE: PA0173 PA1459
            CJE: Cj0924c(cheB')
            SME: SMc03010(cheB)
            ATU: AGR_C_916
            CCR: CC0436 CC0597
            BSU: BG10255(cheB)
            BHA: BH2435(cheB)
            CAC: CAC2222(cheB)
            BBU: BB0415(cheB-1) BB0568(cheB-2)
            TPA: TP0631
            TMA: TM0408
            AFU: AF1041(cheB)
            HAL: VNG0973G(cheB)
            PHO: PH0483(cheB)
            PAB: PAB1331(cheB)
STRUCTURES  PDB: 1A2O  1CHD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.61
            ExPASy - ENZYME nomenclature database: 3.1.1.61
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.61
            BRENDA, the Enzyme Database: 3.1.1.61
            SCOP (Structural Classification of Proteins): 3.1.1.61
///
ENTRY       EC 3.1.1.62
NAME        Deleted entry
            N-Acetyldiaminopimelate deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
COMMENT     Deleted entry. Now listed as EC 3.5.1.47.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.62
            ExPASy - ENZYME nomenclature database: 3.1.1.62
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.62
///
ENTRY       EC 3.1.1.63
NAME        11-cis-Retinyl-palmitate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     11-cis-Retinyl-palmitate acylhydrolase
REACTION    11-cis-Retinyl palmitate + H2O = 11-cis-Retinol + Palmitate
SUBSTRATE   11-cis-Retinyl palmitate
            H2O
PRODUCT     11-cis-Retinol
            Palmitate
EFFECTOR    Bile salt
COMMENT     Activated by bile salts.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.63
            ExPASy - ENZYME nomenclature database: 3.1.1.63
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.63
            BRENDA, the Enzyme Database: 3.1.1.63
///
ENTRY       EC 3.1.1.64
NAME        all-trans-Retinyl-palmitate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     all-trans-Retinyl-palmitate acylhydrolase
REACTION    all-trans-Retinyl palmitate + H2O = all-trans-Retinol + Palmitate
SUBSTRATE   all-trans-Retinyl palmitate
            H2O
PRODUCT     all-trans-Retinol
            Palmitate
EFFECTOR    Detergents
COMMENT     Requires detergents for activity.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.64
            ExPASy - ENZYME nomenclature database: 3.1.1.64
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.64
            BRENDA, the Enzyme Database: 3.1.1.64
///
ENTRY       EC 3.1.1.65
NAME        L-Rhamnono-1,4-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     L-Rhamnono-1,4-lactone lactonohydrolase
REACTION    L-Rhamnono-1,4-lactone + H2O = L-Rhamnonate
SUBSTRATE   L-Rhamnono-1,4-lactone
            H2O
PRODUCT     L-Rhamnonate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.65
            ExPASy - ENZYME nomenclature database: 3.1.1.65
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.65
            BRENDA, the Enzyme Database: 3.1.1.65
///
ENTRY       EC 3.1.1.66
NAME        5-(3,4-Diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     5-(3,4-Diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase
REACTION    5-(3,4-Diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O =
            5-(3-Hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + Acetate
SUBSTRATE   5-(3,4-Diacetoxybut-1-ynyl)-2,2'-bithiophene
            H2O
PRODUCT     5-(3-Hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene
            Acetate
COMMENT     A highly specific enzyme from Tagetes patula.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.66
            ExPASy - ENZYME nomenclature database: 3.1.1.66
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.66
            BRENDA, the Enzyme Database: 3.1.1.66
///
ENTRY       EC 3.1.1.67
NAME        Fatty-acyl-ethyl-ester synthase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Long-chain-acyl-ethyl-ester acylhydrolase
REACTION    a Long-chain-fatty-acyl ethyl ester + H2O =
            a Long-chain fatty acid + Ethanol
SUBSTRATE   Long-chain-fatty-acyl ethyl ester
            H2O
PRODUCT     Long-chain fatty acid
            Ethanol
            Unsaturated octadecanoic acids
            Palmitate
            Stearate
            Arachidonate
COMMENT     In the reverse reaction, forms ethyl esters from fatty acids and
            ethanol in the absence of coenzyme A or ATP. Best substrates are
            unsaturated octadecanoic acids; palmitate, stearate and
            arachidonate also act, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.67
            ExPASy - ENZYME nomenclature database: 3.1.1.67
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.67
            BRENDA, the Enzyme Database: 3.1.1.67
///
ENTRY       EC 3.1.1.68
NAME        Xylono-1,4-lactonase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     D-Xylono-1,4-lactone lactonohydrolase
REACTION    D-Xylono-1,4-lactone + H2O = D-Xylonate
SUBSTRATE   D-Xylono-1,4-lactone
            H2O
PRODUCT     D-Xylonate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.68
            ExPASy - ENZYME nomenclature database: 3.1.1.68
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.68
            BRENDA, the Enzyme Database: 3.1.1.68
///
ENTRY       EC 3.1.1.69
NAME        N-Acetylglucosaminylphosphatidylinositol deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     N-Acetyl-D-glucosaminylphosphatidylinositol acetyhydrolase
REACTION    N-Acetyl-D-glucosaminylphosphatidylinositol + H2O =
            D-Glucosaminylphosphatidylinositol + Acetate
SUBSTRATE   N-Acetyl-D-glucosaminylphosphatidylinositol
            H2O
PRODUCT     D-Glucosaminylphosphatidylinositol
            Acetate
COMMENT     Involved in the firnatuib of the glycosylphosphatidylinositol
            membrane anchor of the trypanosome variant-surface glycoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.69
            ExPASy - ENZYME nomenclature database: 3.1.1.69
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.69
            BRENDA, the Enzyme Database: 3.1.1.69
///
ENTRY       EC 3.1.1.70
NAME        Cetraxate benzylesterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     Cetraxate-benzyl-ester benzylhydrolase
REACTION    Cetraxate benzyl ester + H2O = Cetraxate + Benzyl alcohol
SUBSTRATE   Cetraxate benzyl ester
            H2O
PRODUCT     Cetraxate
            Benzyl alcohol
COMMENT     Acts on a number of benzyl esters of substituted phenyl
            propanoates, and on the benzyl esters of phenylalanine and
            tyrosine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.70
            ExPASy - ENZYME nomenclature database: 3.1.1.70
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.70
            BRENDA, the Enzyme Database: 3.1.1.70
///
ENTRY       EC 3.1.1.71
NAME        Acetylalkylglycerol acetylhydrolase
            Alkylacetylglycerol acetylhydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
REACTION    2-Acetyl-1-alkyl-sn-glycerol + H2O = 1-Alkyl-sn-glycerol + Acetate
SUBSTRATE   2-Acetyl-1-alkyl-sn-glycerol
            H2O
PRODUCT     1-Alkyl-sn-glycerol
            Acetate
COMMENT     Hydrolysis of the Acetate group from the 1,2- and 1,3- isomers of
            Acetylalkylglycerol occurs at apparently identical rates.
            Differs from Diacylglycerol lipase (EC 3.1.1.34) since 1,2-Diacetyl-
            sn-glycerols are not substrates. It also differs from EC 3.1.1.47
            (2-Acetyl-1-alkyl-glycerophosphocholine esterase).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.71
            ExPASy - ENZYME nomenclature database: 3.1.1.71
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.71
///
ENTRY       EC 3.1.1.72
NAME        Acetylxylan esterase
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
REACTION    Deacetylation of xylans and xylo-oligosaccharides
COMMENT     Catalyses the hydrolysis of acetyl groups from polymeric xylan,
            acetylated xylose, acetylated glucose, alpha-napthyl acetate,
            p-nitrophenyl acetate but not from triacetylglycerol.
            Does not act on acetylated mannan or pectin.
STRUCTURES  PDB: 1QOZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.72
            ExPASy - ENZYME nomenclature database: 3.1.1.72
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.72
            SCOP (Structural Classification of Proteins): 3.1.1.72
///
ENTRY       EC 3.1.1.73
NAME        Feruloyl esterase
            Ferulic acid esterase
            Hydroxycinnamoyl esterase
            Hemicellulase accessory enzymes
            FAE-III
            Cinnamoyl ester hydrolase
            FAEA
            CinnAE
            FAE-I
            FAE-II
CLASS       Hydrolases
            Acting on ester bonds
            Carboxylic ester hydrolases
SYSNAME     4-Hydroxy-3-methoxycinnamoyl-sugar hydrolase
REACTION    Feruloyl-polysaccharide + H2O = Ferulate + Polysaccharide
SUBSTRATE   Feruloyl-polysaccharide
            H2O
PRODUCT     Ferulate
            Polysaccharide
COMMENT     Catalyses the hydrolysis of the 4-hydroxy-3-methoxycinnamoyl
            (feruloyl) group from an esterified sugar, which is usually
            arabinose in "natural" substrates. p-Nitrophenol acetate and methyl
            ferulate are poorer substrates. All microbial ferulate esterases
            are secreted into the culture medium. They are sometimes called
            hemicellulase accessory enzymes, since they help xylanases and
            pectinases to break down plant cell wall hemicellulose.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.1.73
            ExPASy - ENZYME nomenclature database: 3.1.1.73
            WIT (What Is There) Metabolic Reconstruction: 3.1.1.73
///
ENTRY       EC 3.1.2.1
NAME        Acetyl-CoA hydrolase
            Acetyl-CoA deacylase
            Acetyl-CoA acylase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Acetyl-CoA hydrolase
REACTION    Acetyl-CoA + H2O = CoA + Acetate
SUBSTRATE   Acetyl-CoA
            H2O
PRODUCT     CoA
            Acetate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       SCE: YBL015W(ACH1)
            SPO: SPAC1952.09C(spac1952.09c)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.1
            ExPASy - ENZYME nomenclature database: 3.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.1
            BRENDA, the Enzyme Database: 3.1.2.1
///
ENTRY       EC 3.1.2.2
NAME        Palmitoyl-CoA hydrolase
            Long-chain fatty-acyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Palmitoyl-CoA hydrolase
REACTION    Palmitoyl-CoA + H2O = CoA + Palmitate
SUBSTRATE   Palmitoyl-CoA
            H2O
PRODUCT     CoA
            Palmitate
COMMENT     Also hydrolyses CoA thioesters of other long-chain fatty acids.
GENES       HSA: 10005(PTE1) 10965(ZAP128) 11332(HBACH)
MOTIF       PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.2
            ExPASy - ENZYME nomenclature database: 3.1.2.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.2
            BRENDA, the Enzyme Database: 3.1.2.2
///
ENTRY       EC 3.1.2.3
NAME        Succinyl-CoA hydrolase
            Succinyl-CoA acylase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Succinyl-CoA hydrolase
REACTION    Succinyl-CoA + H2O = CoA + Succinate
SUBSTRATE   Succinyl-CoA
            H2O
PRODUCT     CoA
            Succinate
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.3
            ExPASy - ENZYME nomenclature database: 3.1.2.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.3
            BRENDA, the Enzyme Database: 3.1.2.3
///
ENTRY       EC 3.1.2.4
NAME        3-Hydroxyisobutyryl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     3-Hydroxy-2-methylpropanoyl-CoA hydrolase
REACTION    3-Hydroxy-2-methylpropanoyl-CoA + H2O = CoA +
            3-Hydroxy-2-methylpropanoate
SUBSTRATE   3-Hydroxy-2-methylpropanoyl-CoA
            H2O
            3-Hydroxypropanoyl-CoA
PRODUCT     CoA
            3-Hydroxy-2-methylpropanoate
            3-Hydroxypropanoate
COMMENT     Also hydrolyses 3-hydroxypropanoyl-CoA.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.4
            ExPASy - ENZYME nomenclature database: 3.1.2.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.4
            BRENDA, the Enzyme Database: 3.1.2.4
            SCOP (Structural Classification of Proteins): 3.1.2.4
///
ENTRY       EC 3.1.2.5
NAME        Hydroxymethylglutaryl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     (S)-3-Hydroxy-3-methylglutaryl-CoA hydrolase
REACTION    (S)-3-Hydroxy-3-methylglutaryl-CoA + H2O = CoA +
            3-Hydroxy-3-methylglutarate
SUBSTRATE   (S)-3-Hydroxy-3-methylglutaryl-CoA
            H2O
PRODUCT     CoA
            3-Hydroxy-3-methylglutarate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.5
            ExPASy - ENZYME nomenclature database: 3.1.2.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.5
            BRENDA, the Enzyme Database: 3.1.2.5
///
ENTRY       EC 3.1.2.6
NAME        Hydroxyacylglutathione hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     S-(2-Hydroxyacyl)glutathione hydrolase
REACTION    S-(2-Hydroxyacyl)glutathione + H2O = Glutathione +
            a 2-Hydroxycarboxylate
SUBSTRATE   S-(2-Hydroxyacyl)glutathione
            H2O
PRODUCT     Glutathione
            2-Hydroxycarboxylate
COMMENT     Also hydrolyses S-acetoacetylglutathione, more slowly.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0212(gloB)
            ECE: Z0236(gloB)
            ECS: ECs0208
            YPE: YPO1079(gloB)
            HIN: HI1274(glob)
            PMU: PM0685
            XFA: XF2160
            VCH: VC2236
            PAE: PA1813
            BUC: BU246(gloB)
            NME: NMB1997
            NMA: NMA0444
            MLO: mlr3546
            SME: SMc00708(gloB)
            CCR: CC0519
            SYN: sll1019(gloB)
            PAB: PAB0703
            SCE: YDR272W(GLO2) YOR040W(GLO4)
            SPO: SPAC824.07(spac824.07) SPCC13B11.03C(spcc13b11.03c)
            ATH: At2g43430(T1O24.20) At3g10850(T7M13.7)
            CEL: Y17G7B.3
            MMU: 95745(Glo2)
            HSA: 3029(HAGH)
DISEASE     MIM: 138760  Hydroxyacyl glutathione hydrolase; glyoxalase II
STRUCTURES  PDB: 1QH5  1QH3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.6
            ExPASy - ENZYME nomenclature database: 3.1.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.6
            BRENDA, the Enzyme Database: 3.1.2.6
            SCOP (Structural Classification of Proteins): 3.1.2.6
///
ENTRY       EC 3.1.2.7
NAME        Glutathione thioesterase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     S-Acylglutathione hydrolase
REACTION    S-Acylglutathione + H2O = Glutathione + a Carboxylate
SUBSTRATE   S-Acylglutathione
            H2O
PRODUCT     Glutathione
            Carboxylate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.7
            ExPASy - ENZYME nomenclature database: 3.1.2.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.7
            BRENDA, the Enzyme Database: 3.1.2.7
///
ENTRY       EC 3.1.2.8
NAME        Deleted entry
            S-Acetoacylglutathione hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
COMMENT     Deleted entry. Now included with EC 3.1.2.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.8
            ExPASy - ENZYME nomenclature database: 3.1.2.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.8
///
ENTRY       EC 3.1.2.9
NAME        Deleted entry
            S-Acetoacetylhydrolipoate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.9
            ExPASy - ENZYME nomenclature database: 3.1.2.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.9
///
ENTRY       EC 3.1.2.10
NAME        Formyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Formyl-CoA hydrolase
REACTION    Formyl-CoA + H2O = CoA + Formate
SUBSTRATE   Formyl-CoA
            H2O
PRODUCT     CoA
            Formate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.10
            ExPASy - ENZYME nomenclature database: 3.1.2.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.10
            BRENDA, the Enzyme Database: 3.1.2.10
///
ENTRY       EC 3.1.2.11
NAME        Acetoacetyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Acetoacetyl-CoA hydrolase
REACTION    Acetoacetyl-CoA + H2O = CoA + Acetoacetate
SUBSTRATE   Acetoacetyl-CoA
            H2O
PRODUCT     CoA
            Acetoacetate
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.11
            ExPASy - ENZYME nomenclature database: 3.1.2.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.11
            BRENDA, the Enzyme Database: 3.1.2.11
///
ENTRY       EC 3.1.2.12
NAME        S-Formylglutathione hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     S-Formylglutathione hydrolase
REACTION    S-Formylglutathione + H2O = Glutathione + Formate
SUBSTRATE   S-Formylglutathione
            H2O
PRODUCT     Glutathione
            Formate
COMMENT     Also hydrolyses S-acetylglutathione, more slowly.
PATHWAY     PATH: MAP00680  Methane metabolism
GENES       SME: SMb20171 SMc01273
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.12
            ExPASy - ENZYME nomenclature database: 3.1.2.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.12
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.2.12
            BRENDA, the Enzyme Database: 3.1.2.12
///
ENTRY       EC 3.1.2.13
NAME        S-Succinylglutathione hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     S-Succinylglutathione hydrolase
REACTION    S-Succinylglutathione + H2O = Glutathione + Succinate
SUBSTRATE   S-Succinylglutathione
            H2O
PRODUCT     Glutathione
            Succinate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.13
            ExPASy - ENZYME nomenclature database: 3.1.2.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.13
            BRENDA, the Enzyme Database: 3.1.2.13
///
ENTRY       EC 3.1.2.14
NAME        Oleoyl-[acyl-carrier-protein] hydrolase
            Acyl-[acyl-carrier-protein] hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Oleoyl-[acyl-carrier-protein] hydrolase
REACTION    Oleoyl-[acyl-carrier protein] + H2O = [Acyl-carrier protein] +
            Oleate
SUBSTRATE   Oleoyl-[acyl-carrier protein]
            H2O
PRODUCT     Acyl-carrier protein
            Oleate
COMMENT     Acts on acyl-carrier-protein thioesters of fatty acids from C12
            to C18, but the derivative of oleic acid is hydrolysed much more
            rapidly than any other compound tested.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
            PATH: MAP00062  Fatty acid biosynthesis (path 2)
GENES       SCE: YKL182W(FAS1)
            SPO: SPAC926.09C(spac926.09c)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00122  F-[GR]-G-x(4)-[LIVM]-x-[LIV]-x-G-x-S-[STAG]-G
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS00941  [ED]-D-C-L-[YT]-[LIV]-[DNS]-[LIV]-[LIVFYW]-x-[PQR]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.14
            ExPASy - ENZYME nomenclature database: 3.1.2.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.14
            BRENDA, the Enzyme Database: 3.1.2.14
///
ENTRY       EC 3.1.2.15
NAME        Ubiquitin thiolesterase
            Ubiquitin carboxy-terminal esterase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Ubiquitin-C-terminal-thiolester hydrolase
REACTION    Ubiquitin C-terminal thiolester + H2O = Ubiquitin + a Thiol
SUBSTRATE   Ubiquitin C-terminal thiolester
            H2O
            Dithiothreitol
            Glutathione
            C-terminal glycine residue of the polypeptide ubiquitin
            AMP-ubiquitin
PRODUCT     Ubiquitin
            Thiol
COMMENT     Acts on esters formed between thiols such as dithiothreitol or
            glutathione and the C-terminal glycine residue of the polypeptide
            ubiquitin.  Also acts on AMP-ubiquitin.
GENES       SCE: YBL067C(UBP13) YBR058C(UBP14) YDL122W(UBP1) YDR069C(DOA4)
                 YER098W(UBP9) YER144C(UBP5) YER151C(UBP3) YFR010W(UBP6)
                 YIL156W(UBP7) YJL197W(UBP12) YJR099W(YUH1) YKR098C(UBP11)
                 YMR223W(UBP8) YMR304W(UBP15) YNL186W(DOT4) YOR124C(UBP2)
                 YPL072W(UBP16)
            SPO: SPAC13A11.04C(spac13a11.04c) SPAC27F1.03C(spac27f1.03c)
                 SPAC6G9.08(spac6g9.08) SPBC1703.12(spbc1703.12)
                 SPBC18H10.08C(spbc18h10.08c) SPCC188.08C(spcc188.08c)
                 UBPD(ubpD)
            ATH: At4g39910(T5J17.80)
            CEL: H34C03.2 K02C4.3 R10E11.3 T27A3.2
            DME: CG11025 CG12082 CG1490 CG1945(faf) CG3431(Uch-L3) CG4166(not)
                 CG4265(Uch) CG5486(Ubp64E) CG7023
            HSA: 10600(USP16) 10868(USP20) 11274(USP18) 27005(USP21)
                 29761(USP25) 7345(UCHL1) 7347(UCHL3) 7375(USP4) 7398(USP1)
                 7874(USP7) 8078(USP5) 8237(USP11) 8239(USP9X) 8287(USP9Y)
                 8975(USP13) 9099(USP2) 9101(USP8) 9960(USP3)
DISEASE     MIM: 191342  Ubiquitin C-terminal esterase L1
MOTIF       PS: PS00140  Q-x(3)-N-[SA]-C-G-x(3)-[LIVM](2)-H-[SA]-[LIVM]-[SA]
            PS: PS00299  K-x(2)-[LIVM]-x-[DESAK]-x(3)-[LIVM]-[PA]-x(3)-Q-x-
                         [LIVM]-[LIVMC]-[LIVMFY]-x-G-x(4)-[DE]
            PS: PS00972  G-[LIVMFY]-x(1,3)-[AGC]-[NASM]-x-C-[FYW]-[LIVMFC]-
                         [NST]-[SACV]-x-[LIVMS]-Q
            PS: PS00973  Y-x-L-x-[SAG]-[LIVMFT]-x(2)-H-x-G-x(4,5)-G-H-Y
            PS: PS50053  Ubiquitin domain profile
STRUCTURES  PDB: 1CMX  1UCH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.15
            ExPASy - ENZYME nomenclature database: 3.1.2.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.15
            BRENDA, the Enzyme Database: 3.1.2.15
            SCOP (Structural Classification of Proteins): 3.1.2.15
///
ENTRY       EC 3.1.2.16
NAME        [Citrate-(pro-3S)-lyase] thiolesterase
            Citrate lyase deacetylase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     [Citrate-(pro-3S)-lyase](acetyl-form) hydrolase
REACTION    [Citrate (pro-3S)-lyase](acetyl form) + H2O =
            [Citrate (pro-3S)-lyase](thiol form) + Acetate
SUBSTRATE   [Citrate (pro-3S)-lyase](acetyl form)
            H2O
PRODUCT     [Citrate (pro-3S)-lyase](thiol form)
            Acetate
COMMENT     Hydrolysis inactivates EC 4.1.3.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.16
            ExPASy - ENZYME nomenclature database: 3.1.2.16
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.16
            BRENDA, the Enzyme Database: 3.1.2.16
///
ENTRY       EC 3.1.2.17
NAME        (S)-Methylmalonyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     (S)-Methylmalonyl-CoA hydrolase
REACTION    (S)-Methylmalonyl-CoA + H2O = Methylmalonate + CoA
SUBSTRATE   (S)-Methylmalonyl-CoA
            H2O
PRODUCT     Methylmalonate
            CoA
PATHWAY     PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.17
            ExPASy - ENZYME nomenclature database: 3.1.2.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.17
            BRENDA, the Enzyme Database: 3.1.2.17
///
ENTRY       EC 3.1.2.18
NAME        ADP-dependent short-chain-acyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     ADP-dependent-short-chain-acyl-CoA hydrolase
REACTION    Acyl-CoA + H2O = CoA + a Carboxylate
SUBSTRATE   Acyl-CoA
            H2O
            Propanoyl-CoA
PRODUCT     CoA
            Carboxylate
            Propanoate
INHIBITOR   NADH
COFACTOR    ADP
COMMENT     Requires ADP; inhibited by NADH. Maximum activity is shown with
            propanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.18
            ExPASy - ENZYME nomenclature database: 3.1.2.18
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.18
            BRENDA, the Enzyme Database: 3.1.2.18
///
ENTRY       EC 3.1.2.19
NAME        ADP-dependent medium-chain-acyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     ADP-dependent-medium-chain-acyl-CoA hydrolase
REACTION    Acyl-CoA + H2O = CoA + a Carboxylate
SUBSTRATE   Acyl-CoA
            H2O
            Nonanoyl-CoA
PRODUCT     CoA
            Carboxylate
            Nonanoate
INHIBITOR   NADH
COFACTOR    ADP
COMMENT     Requires ADP; inhibited by NADH. Maximum activity is shown with
            nonanoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.19
            ExPASy - ENZYME nomenclature database: 3.1.2.19
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.19
            BRENDA, the Enzyme Database: 3.1.2.19
///
ENTRY       EC 3.1.2.20
NAME        Acyl-CoA hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     Acyl-CoA hydrolase
REACTION    Acyl-CoA + H2O = CoA + a Carboxylate
SUBSTRATE   Acyl-CoA
            H2O
PRODUCT     CoA
            Carboxylate
COMMENT     Broad specificity for medium- to long-chain acyl-CoA. Insensitive
            to NAD+ (cf. EC 3.1.2.19).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.20
            ExPASy - ENZYME nomenclature database: 3.1.2.20
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.20
            BRENDA, the Enzyme Database: 3.1.2.20
///
ENTRY       EC 3.1.2.21
NAME        Dodecanoyl-[acyl-carrier protein] hydrolase
            Dodecyl-[acyl-carrier protein] hydrolase
            Lauryl-[acyl-carrier protein] hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
REACTION    Dodecanoyl-[acyl-carrier protein] + H2O = [Acyl-carrier protein] +
            Dodecanoate
SUBSTRATE   Dodecanoyl-[acyl-carrier protein]
            H2O
PRODUCT     [Acyl-carrier protein]
            Dodecanoate
COMMENT     Acts on the Acyl-carrier protein thioesters of C(12) and, at a
            much lower activity, C(14) fatty acids.
            The derivative of Oleic acid id hydrolysed very slowly.
DISEASE     MIM: 600722  Palmitoyl-protein thioesterase 1
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.21
            ExPASy - ENZYME nomenclature database: 3.1.2.21
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.21
///
ENTRY       EC 3.1.2.22
NAME        Palmitoyl-protein hydrolase
            Palmitoyl-protein thioesterase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
REACTION    Palmitoyl-protein + H2O = Palmitate + Protein
SUBSTRATE   Palmitoyl-protein
            H2O
PRODUCT     Palmitate
            Protein
COMMENT     Specific for long-chain thioesters of fatty acids. Hydrolyses fatty
            acids from S-acylated cysteine residues in proteins, palmitoyl
            cysteine and palmitoyl-CoA.
GENES       HSA: 5538(PPT1)
STRUCTURES  PDB: 1EXW  1EI9  1EH5  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.22
            ExPASy - ENZYME nomenclature database: 3.1.2.22
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.22
            SCOP (Structural Classification of Proteins): 3.1.2.22
///
ENTRY       EC 3.1.2.23
NAME        4-Hydroxybenzoyl-CoA thioesterase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
REACTION    4-Hydroxybenzoyl-CoA + H2O = 4-Hydroxybenzoate + CoA
SUBSTRATE   4-Hydroxybenzoyl-CoA
            H2O
PRODUCT     4-Hydroxybenzoate
            CoA
COMMENT     This enzyme is part of the bacterial 2,4-dichlorobenzoate
            degradation pathway.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
MOTIF       PS: PS01328  [QR]-[IV]-x(4)-[TC]-D-x(2)-G-[IV]-V-x-[HF]-x(2)-[FY]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.23
            ExPASy - ENZYME nomenclature database: 3.1.2.23
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.23
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.2.23
///
ENTRY       EC 3.1.2.24
NAME        2-(2-Hydroxyphenyl)benzenesulfinate hydrolase
            Gene dsz B-encoded hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Thiolester hydrolases
SYSNAME     2-(2-Hydroxyphenyl) benzenesulfinate:H2O hydrolase
REACTION    2-(2-Hydroxyphenyl)benzenesulfinate + H2O = 2-Hydroxybiphenyl +
            Sulfite
SUBSTRATE   2-(2-Hydroxyphenyl)benzenesulfinate
            H2O
PRODUCT     2-Hydroxybiphenyl
            Sulfite
COMMENT     The enzyme from Rhodococcus sp. strain IGTS8 is encoded by the
            plasmid-encoded dibenzothiophene-desulfurization (dsz) operon.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.2.24
            ExPASy - ENZYME nomenclature database: 3.1.2.24
            WIT (What Is There) Metabolic Reconstruction: 3.1.2.24
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.2.24
///
ENTRY       EC 3.1.3.1
NAME        Alkaline phosphatase
            Alkaline phosphomonoesterase
            Phosphomonoesterase
            Glycerophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Orthophosphoric-monoester phosphohydrolase (alkaline optimum)
REACTION    an Orthophosphoric monoester + H2O = an Alcohol + Orthophosphate
SUBSTRATE   Orthophosphoric monoester
            H2O
PRODUCT     Alcohol
            Orthophosphate
COMMENT     Wide specificity. Also catalyses transphosphorylations. The
            human placental enzyme is a zinc protein. Some enzymes hydrolyse
            pyrophosphate (cf. EC 3.6.1.1).
            (EC 3.6.1.1 Inorganic pyrophosphatase)
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00790  Folate biosynthesis
GENES       ECO: b0383(phoA)
            ECE: Z0479(phoA)
            ECS: ECs0433
            YPE: YPO2298(phoA)
            XFA: XF0657
            PAE: PA3296(phoA)
            SME: SMc03243
            CCR: CC0455 CC1565
            BSU: BG10183(phoA) BG10697(phoB)
            BHA: BH0874
            SAU: SA2420(phoB)
            SAV: SAV2611(phoB)
            SYN: sll0222(phoA) sll0654
            TMA: TM0156
            PAB: PAB2366(phoA)
            SCE: YDR481C(PHO8)
            SPO: SPBC14F5.13C(spbc14f5.13c)
            DME: CG10592 CG10827 CG1462(Aph-4) CG16771 CG1809 CG3264 CG3290
                 CG3292 CG5150 CG5656 CG8147
            MMU: 87982(Akp1) 87983(Akp2) 87984(Akp3)
            HSA: 248(ALPI) 249(ALPL) 250(ALPP) 251(ALPPL2)
DISEASE     MIM: 171740  Alkaline phosphatase, intestinal
            MIM: 171760  Alkaline phosphatase, liver/bone/kidney
            MIM: 171800  Alkaline phosphatase, placental (Regan isozyme)
            MIM: 171810  Alkaline phosphatase, placental-like 2
MOTIF       PS: PS00123  [IV]-x-D-S-[GAS]-[GASC]-[GAST]-[GA]-T
STRUCTURES  PDB: 1AJA  1ALJ  1AJB  1AJC  1AJD  1ALH  1ALK  1ANI  1ANJ  1B8J  
                 1ED8  1ALI  1ED9  1ELX  1ELY  1ELZ  1EW2  1HJK  1HQA  1URA  
                 1URB  2ANH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.1
            ExPASy - ENZYME nomenclature database: 3.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.1
            BRENDA, the Enzyme Database: 3.1.3.1
            SCOP (Structural Classification of Proteins): 3.1.3.1
///
ENTRY       EC 3.1.3.2
NAME        Acid phosphatase
            Acid phosphomonoesterase
            Phosphomonoesterase
            Glycerophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Orthophosphoric-monoester phosphohydrolase (acid optimum)
REACTION    an Orthophosphoric monoester + H2O = an Alcohol + Orthophosphate
SUBSTRATE   Orthophosphoric monoester
            H2O
PRODUCT     Alcohol
            Orthophosphate
INHIBITOR   (R,R)-Tartaric acid
COMMENT     Wide specificity. Also calyses transphosphorylations.
            Inhibited by L(+)-tartrate ( J.Biol.Chem 268, 20744-20746 (1993)).
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0980(appA) b4055(aphA)
            ECE: Z1397(appA) Z5654(aphA)
            ECS: ECs1136 ECs5037
            YPE: YPO1648
            HIN: HI0494 HI0495
            MLO: mll2704
            SPY: SPy1113
            PAB: PAB2021
            SCE: YAR071W(PHO11) YBR092C(PHO3) YBR093C(PHO5) YDL024C
                 YHR215W(PHO12) YPR073C(LTP1)
            SPO: PHO1(pho1) PHO4(pho4) SPBC21H7.03C(spbc21h7.03c) STP1(stp1)
            ATH: At2g27190(T22O13.4)
            CEL: B0361.7 C05C10.1 C05C10.4 F26C11.1
            DME: CG7899
            MMU: 87881(Acp1) 87882(Acp2) 87883(Acp5)
            HSA: 52(ACP1) 53(ACP2) 54(ACP5) 55(ACPP)
DISEASE     MIM: 171640  Acid phosphatase 5, tartrate resistant
            MIM: 171650  Acid phosphatase 2, lysosomal
            MIM: 171790  Acid phosphatase, prostate
MOTIF       PS: PS00616  [LIVM]-x(2)-[LIVMA]-x(2)-[LIVM]-x-R-H-[GN]-x-R-x-[PAS]
            PS: PS00778  [LIVMF]-x-[LIVMFAG]-x(2)-[STAGI]-H-D-[STANQ]-x-[LIVM]-
                         x(2)-[LIVMFY]-x(2)-[STA]
            PS: PS01157  G-S-Y-P-S-G-H-T
STRUCTURES  PDB: 5PNT  4KBP  3KBP  2HPA  1UTE  1RPT  1RPA  1QHW  1QFC  1PNT  
                 1KBP  1EOI  1DKQ  1DKP  1DKO  1DKN  1DKM  1DKL  1D2T  1CVI  
                 1C0E  1BVH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.2
            ExPASy - ENZYME nomenclature database: 3.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.2
            BRENDA, the Enzyme Database: 3.1.3.2
            SCOP (Structural Classification of Proteins): 3.1.3.2
///
ENTRY       EC 3.1.3.3
NAME        Phosphoserine phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     O-Phosphoserine phosphohydrolase
REACTION    L-O-Phosphoserine or D-O-Phosphoserine + H2O = L-Serine or 
            D-Serine + Orthophosphate
SUBSTRATE   L-O-Phosphoserine
            D-O-Phosphoserine
            H2O
PRODUCT     L-Serine
            D-Serine
            Orthophosphate
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b4388(serB)
            ECE: Z5989(serB)
            ECS: ECs5346
            YPE: YPO0442(serB)
            HIN: HI1033(serB)
            PMU: PM1657(serB)
            VCH: VC2345
            PAE: PA4960
            NME: NMB0981
            NMA: NMA1179(serB)
            HPY: HP0652(serB)
            HPJ: jhp0597
            CJE: Cj0282c(serB)
            MLO: mlr1449
            SME: SMc01494(serB)
            CCR: CC2097
            LLA: L0085(serB)
            MTU: Rv0505c(serB) Rv3042c(serB2)
            MTC: MT0526 MT3127
            MLE: ML1727
            MJA: MJ1594(serB)
            MTH: MTH1626
            AFU: AF2138(serB)
            HAL: VNG2423G(serB)
            TAC: Ta0936
            TVO: TVG1139499
            PHO: PH0134 PH1885
            PAB: PAB1207(serB)
            APE: APE0683
            SCE: YGR208W(SER2)
            SPO: SPBC3H7.07C(spbc3h7.07c)
            DME: CG3705(aay)
            HSA: 5723(PSPH)
STRUCTURES  PDB: 1F5S  1J97  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.3
            ExPASy - ENZYME nomenclature database: 3.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.3
            BRENDA, the Enzyme Database: 3.1.3.3
///
ENTRY       EC 3.1.3.4
NAME        Phosphatidate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     3-sn-Phosphatidate phosphohydrolase
REACTION    1,2-Diacyl-sn-glycerol 3-phosphate + H2O = 
            1,2-Diacyl-sn-glycerol + Orthophosphate
SUBSTRATE   1,2-Diacyl-sn-glycerol 3-phosphate
            H2O
PRODUCT     1,2-Diacyl-sn-glycerol
            Orthophosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.4
            ExPASy - ENZYME nomenclature database: 3.1.3.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.4
            BRENDA, the Enzyme Database: 3.1.3.4
///
ENTRY       EC 3.1.3.5
NAME        5'-Nucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     5'-Ribonucleotide phosphohydrolase
REACTION    a 5'-Ribonucleotide + H2O = a Ribonucleoside + Orthophosphate
SUBSTRATE   5'-Ribonucleotide
            H2O
PRODUCT     Ribonucleoside
            Orthophosphate
COMMENT     Wide specificity for 5'-nucleotides.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b0480(ushA)
            ECE: Z0599(ushA)
            ECS: ECs0533
            HIN: HI0206
            PMU: PM1193
            VCH: VC2174
            MLO: mlr3017
            SME: SMc04018
            BSU: BG12930(yfkN)
            MPU: MYPU_0550
            TPA: TP0104
            SYN: slr0306
            TMA: TM1878
            MTH: MTH1492
            AFU: AF0876(nt5)
            DME: CG6247
            HSA: 22978(NT5B) 4877(NT3) 4907(NT5) 7370(UMPH2)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00785  [LIVM]-x-[LIVM](2)-[HEA]-[TI]-x-D-x-H-[GSA]-x-[LIVMF]
            PS: PS00786  [FYP]-x(4)-[LIVM]-G-N-H-E-F-[DN]
STRUCTURES  PDB: 1USH  2USH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.5
            ExPASy - ENZYME nomenclature database: 3.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.5
            BRENDA, the Enzyme Database: 3.1.3.5
            SCOP (Structural Classification of Proteins): 3.1.3.5
///
ENTRY       EC 3.1.3.6
NAME        3'-Nucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     3'-Ribonucleotide phosphohydrolase
REACTION    a 3'-Ribonucleotide + H2O = a Ribonucleoside + Orthophosphate
SUBSTRATE   3'-Ribonucleotide
            H2O
PRODUCT     Ribonucleoside
            Orthophosphate
COMMENT     Wide specificity for 3'-nucleotides.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.6
            ExPASy - ENZYME nomenclature database: 3.1.3.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.6
            BRENDA, the Enzyme Database: 3.1.3.6
///
ENTRY       EC 3.1.3.7
NAME        3'(2'),5'-Bisphosphate nucleotidase
            Phosphoadenylate 3'-nucleotidase
            3'-Phosphoadenylylsulfate 3'-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase
REACTION    Adenosine 3',5'-bisphosphate + H2O = Adenosine 5'-phosphate +
            Orthophosphate
SUBSTRATE   Adenosine 3',5'-bisphosphate
            H2O
            Adenosine 2',5'-bisphosphate
            3'-Phosphoadenylylsulfate
            2'-Phosphoadenylylsulfate
PRODUCT     Adenosine 5'-phosphate
            Orthophosphate
            Adenylylsulfate
COMMENT     Also acts on 3'-phosphoadenylylsulfate, and on the corresponding
            2'-phosphates.
PATHWAY     PATH: MAP00920  Sulfur metabolism
GENES       HSA: 10380(BPNT1)
MOTIF       PS: PS00629  [FWV]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-[ST]-x(2)-[FY]-x-
                         [HKRNSTY]
            PS: PS00630  [WV]-D-x-[AC]-[GSA]-[GSAPV]-x-[LIVACP]-[LIV]-[LIVAC]-
                         x(3)-[GH]-[GA]
STRUCTURES  PDB: 1JP4  1QGX  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.7
            ExPASy - ENZYME nomenclature database: 3.1.3.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.7
            BRENDA, the Enzyme Database: 3.1.3.7
            SCOP (Structural Classification of Proteins): 3.1.3.7
///
ENTRY       EC 3.1.3.8
NAME        3-Phytase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     myo-Inositol-hexakisphosphate 3-phosphohydrolase
REACTION    myo-Inositol hexakisphosphate + H2O =
            D-myo-Inositol 1,2,4,5,6-pentakisphosphate + Orthophosphate
SUBSTRATE   myo-Inositol hexakisphosphate
            H2O
PRODUCT     D-myo-Inositol 1,2,4,5,6-pentakisphosphate
            Orthophosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       BSU: BG11198(phy)
MOTIF       PS: PS00616  [LIVM]-x(2)-[LIVMA]-x(2)-[LIVM]-x-R-H-[GN]-x-R-x-[PAS]
            PS: PS00778  [LIVMF]-x-[LIVMFAG]-x(2)-[STAGI]-H-D-[STANQ]-x-[LIVM]-
                         x(2)-[LIVMFY]-x(2)-[STA]
STRUCTURES  PDB: 1QLG  1IHP  2POO  1QFX  1POO  1CVM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.8
            ExPASy - ENZYME nomenclature database: 3.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.8
            BRENDA, the Enzyme Database: 3.1.3.8
            SCOP (Structural Classification of Proteins): 3.1.3.8
///
ENTRY       EC 3.1.3.9
NAME        Glucose-6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Glucose-6-phosphate phosphohydrolase
REACTION    D-Glucose 6-phosphate + H2O = D-Glucose + Orthophosphate
SUBSTRATE   D-Glucose 6-phosphate
            H2O
PRODUCT     D-Glucose
            Orthophosphate
COMMENT     Wide distribution in animal tissues. Also catalyses potent
            transphosphorylations from carbamoyl phosphate, hexose phosphates,
            pyrophosphate, phosphoenolpyruvate and nucleoside di- and tri-
            phosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or
            2-deoxy-D-glucose (cf. EC 2.7.1.62, 2.7.1.79 and 3.9.1.1).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
GENES       HSA: 2538(G6PC)
DISEASE     MIM: 232200  Glucose-6-phosphatase, catalytic
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.9
            ExPASy - ENZYME nomenclature database: 3.1.3.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.9
            BRENDA, the Enzyme Database: 3.1.3.9
///
ENTRY       EC 3.1.3.10
NAME        Glucose-1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Glucose-1-phosphate phosphohydrolase
REACTION    D-Glucose 1-phosphate + H2O = D-Glucose + Orthophosphate
SUBSTRATE   D-Glucose 1-phosphate
            H2O
            D-Galactose 1-phosphate
PRODUCT     D-Glucose
            Orthophosphate
            D-Galactose
COMMENT     Also acts, more slowly, on D-galactose 1-phosphate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       ECO: b1002(agp)
            ECE: Z1421(agp)
            ECS: ECs1158
MOTIF       PS: PS00616  [LIVM]-x(2)-[LIVMA]-x(2)-[LIVM]-x-R-H-[GN]-x-R-x-[PAS]
            PS: PS00778  [LIVMF]-x-[LIVMFAG]-x(2)-[STAGI]-H-D-[STANQ]-x-[LIVM]-
                         x(2)-[LIVMFY]-x(2)-[STA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.10
            ExPASy - ENZYME nomenclature database: 3.1.3.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.10
            BRENDA, the Enzyme Database: 3.1.3.10
///
ENTRY       EC 3.1.3.11
NAME        Fructose-bisphosphatase
            Hexosediphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Fructose-1,6-bisphosphate 1-phosphohydrolase
REACTION    D-Fructose 1,6-bisphosphate + H2O = D-Fructose 6-phosphate +
            Orthophosphate;
            Sedoheptulose 1,7-bisphosphate + H2O =
            Sedoheptulose 7-phosphate + Orthophosphate
SUBSTRATE   D-Fructose 1,6-bisphosphate
            Sedoheptulose 1,7-bisphosphate
            H2O
PRODUCT     D-Fructose 6-phosphate
            Sedoheptulose 7-phosphate
            Orthophosphate
COMMENT     The animal enzyme also acts on sedoheptulose 1,7-bisphosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b4232(fbp)
            ECE: Z5842(fbp)
            ECS: ECs5209
            YPE: YPO3520(fbp)
            HIN: HI1645(fbp)
            PMU: PM0930(fbp)
            VCH: VC2544
            PAE: PA5110(fbp)
            NME: NMB1060
            NMA: NMA1259(fbp)
            HPY: HP1385
            HPJ: jhp1440
            CJE: Cj0840c(fbp)
            SME: SMb20202(cbbF)
            CCR: CC1385
            BSU: BG11478(fbp)
            SAU: SA2304(fbp)
            SAV: SAV2499(fbp)
            LLA: L54021(fbp)
            CAC: CAC1572
            SYN: slr0952(fbp)
            SCE: YLR377C(FBP1)
            SPO: FBP1(fbp1)
            DME: CG10611
            HSA: 2203(FBP1) 8789(FBP2)
DISEASE     MIM: 229700  Fructose-bisphosphatase 1
MOTIF       PS: PS00124  [AG]-[RK]-[LI]-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA]
STRUCTURES  PDB: 1RDY  1RDZ  1SPI  1FTA  1RDX  1FSA  1FRP  2FBP  3FBP  1FPG  
                 1FPI  1FPF  1FPE  1FPD  1FPB  1FJ9  1FJ6  1FBP  1FBH  1FBG  
                 1FBF  1FBE  1FBD  1FBC  1EYK  1EYJ  1EYI  1DCU  1DBZ  1D9Q  
                 1CNQ  1BK4  1FPJ  1FPK  5FBP  1FPL  4FBP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.11
            ExPASy - ENZYME nomenclature database: 3.1.3.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.11
            BRENDA, the Enzyme Database: 3.1.3.11
            SCOP (Structural Classification of Proteins): 3.1.3.11
///
ENTRY       EC 3.1.3.12
NAME        Trehalose-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Trehalose-6-phosphate phosphohydrolase
REACTION    alpha,alpha'-Trehalose 6-phosphate + H2O = alpha,alpha'-Trehalose + 
            Orthophosphate
SUBSTRATE   alpha,alpha'-Trehalose 6-phosphate
            H2O
PRODUCT     alpha,alpha'-Trehalose
            Orthophosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1897(otsB)
            ECE: Z2950(otsB)
            ECS: ECs2605
            MLO: mll0690
            MTU: Rv3372(otsB2)
            MTC: MT3482
            MLE: ML0414(otsB2)
            MTH: MTH1760
            TAC: Ta1209
            TVO: TVG1319820
            SCE: YDR074W(TPS2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.12
            ExPASy - ENZYME nomenclature database: 3.1.3.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.12
            BRENDA, the Enzyme Database: 3.1.3.12
///
ENTRY       EC 3.1.3.13
NAME        Bisphosphoglycerate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     2,3-Bisphospho-D-glycerate 2-phosphohydrolase
REACTION    2,3-Bisphospho-D-glycerate + H2O = 3-Phospho-D-glycerate +
            Orthophosphate
SUBSTRATE   2,3-Bisphospho-D-glycerate
            H2O
PRODUCT     3-Phospho-D-glycerate
            Orthophosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       HSA: 5223(PGAM1) 5224(PGAM2) 669(BPGM)
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.13
            ExPASy - ENZYME nomenclature database: 3.1.3.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.13
            BRENDA, the Enzyme Database: 3.1.3.13
///
ENTRY       EC 3.1.3.14
NAME        Methylphosphothioglycerate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     S-Methyl-3-phospho-1-thio-D-glycerate phosphohydrolase
REACTION    S-Methyl-3-phospho-1-thio-D-glycerate + H2O =
            S-Methyl-1-thio-D-glycerate + Orthophosphate
SUBSTRATE   S-Methyl-3-phospho-1-thio-D-glycerate
            H2O
PRODUCT     S-Methyl-1-thio-D-glycerate
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.14
            ExPASy - ENZYME nomenclature database: 3.1.3.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.14
            BRENDA, the Enzyme Database: 3.1.3.14
///
ENTRY       EC 3.1.3.15
NAME        Histidinol-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     L-Histidinol-phosphate phosphohydrolase
REACTION    L-Histidinol phosphate + H2O = L-Histidinol + Orthophosphate
SUBSTRATE   L-Histidinol phosphate
            H2O
PRODUCT     L-Histidinol
            Orthophosphate
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2022(hisB)
            ECE: Z3184(hisB)
            ECS: ECs2823
            YPE: YPO1546(hisB)
            HIN: HI0471(hisB)
            PMU: PM1200(hisB)
            XFA: XF2217
            VCH: VC1135
            BUC: BU102(hisB)
            CJE: Cj1599(hisB)
            BSU: BG13931(hisJ)
            BHA: BH3206
            LLA: L37351(hisK)
            DRA: DR0470
            TMA: TM0804
            SCE: YFR025C(HIS2)
            SPO: SPCC1672.01(spcc1672.01)
MOTIF       PS: PS00954  [LIVMY]-[DE]-x-H-H-x(2)-E-x(2)-[GCA]-[LIVM]-[STAVC]-
                         [LIVM]
            PS: PS00955  G-x-[DNI]-x-H-H-x(2)-E-[STAGC]-x-[VMFY]-K
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.15
            ExPASy - ENZYME nomenclature database: 3.1.3.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.15
            BRENDA, the Enzyme Database: 3.1.3.15
            SCOP (Structural Classification of Proteins): 3.1.3.15
///
ENTRY       EC 3.1.3.16
NAME        Phosphoprotein phosphatase
            Protein phosphatase-1
            Protein phosphatase-2A
            Protein phosphatase-2B
            Protein phosphatase-2C
            Calcineurin
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Phosphoprotein phosphohydrolase
REACTION    a Phosphoprotein + H2O = a Protein + Orthophosphate
SUBSTRATE   Phosphoprotein
            H2O
            Casein
            Phenolic phosphate
            Phosphoamide
PRODUCT     Protein
            Orthophosphate
INHIBITOR   FK506
            Cyclosporin A
            Okadaic acid
            Calyculin A
            Microcystin-LR
            Tautomycin
COFACTOR    Calcium
            Calmodulin
COMMENT     A group of enzymes removing the serine- or threonine-bound
            phosphate group from a wide range of phosphoproteins, including a
            number of enzymes which have been phosphorylated under the action
            of a kinase (cf. EC 3.1.3.48). The spleen enzyme also acts on
            phenolic phosphates and phosphamides. (cf. EC 3.9.1.1).
            Protein phosphatase-1 is inhibited by proteins (inhibitors 1 and
            2).  Protein phosphatase-2's are not inhibited by inhibitor
            proteins. Protein phosphatase-2B and -2C require metal ions,
            Ca/calmoduline and Mg, respectively.
            Calcineurin is calcium binding and calmoduline binding protein.
            It is a calcium dependent, calmodulin stimulated protein
            phosphatase.  Subunit is composed of two components A and B.
            The A component is the catalytic subunit and the B component
            confers calcium sensitivity.  
            The phosphate group bound to tyrosine residue is removed by 
            protein tyrosine phosphatase (cf. EC 3.1.3.48)
GENES       ECO: b1838(ppha) b2734(pphb)
            ECE: Z2885(pphA) Z4044(pphB)
            ECS: ECs2548 ECs3590
            SME: SMb21213(pphA)
            BSU: BG10127(spoIIE) BG10736(rsbX) BG11057(rsbU) BG12441(rsbP)
                 BG13390(prpC)
            BHA: BH0078(spoIIE) BH0526(rsbU) BH0530(rsbX)
            SPN: SP1201
            SPR: spr1083(pphA)
            CAC: CAC2787
            MGE: MG108
            MPN: K04_orf259(ptc1)
            MPU: MYPU_6860
            DRA: DR0295 DR2249
            TMA: TM0742
            AFU: AF1822(ppa)
            APE: APE0777
            SSO: SSO1090
            SCE: YBL056W(PTC3) YBR125C(PTC4) YDL006W(PTC1) YDL047W(SIT4)
                 YDL134C(PPH21) YDL188C(PPH22) YDR075W(PPH3) YDR436W(PPZ2)
                 YER089C(PTC2) YER133W(GLC7) YGR123C(PPT1) YLR433C(CNA1)
                 YML016C(PPZ1) YML057W(CMP2) YNR032W(PPG1) YPL179W(PPQ1)
            SPO: DIS2(dis2) PAA1(paa1) PHZ1(phz1) PPA1_1(ppa1) PPA2(ppa2)
                 PPB1(ppb1) PPE1(ppe1) PTC1(ptc1) PTC2(ptc2) PTC3(ptc3)
                 SDS21(sds21) SPAC22H10.04(spac22h10.04)
                 SPBC26H8.05C(spbc26h8.05c) SPBC3F6.01C(spbc3f6.01c)
            ATH: At1g10430(T10O24.4) At1g59830(F23H11.15) At1g64030(F22C12.22)
                 At2g29400(F16P2.22) At2g39840(T5I7.14) At2g42500(F14N22.23)
                 At3g11410(F24K9.8) At4g11240(F8L21.30) At4g26080(F20B18.190)
                 At4g26720(F10M23.60) At4g27800(T27E11.40)
            CEL: C02F4.2 C05A2.1 C06A1.3 C09H5.7 C23G10.1 C27B7.6 C34C12.3
                 C34D4.2 F23B12.1 F25B3.4 F25D1.1 F26B1.5 F26E4.1 F29F11.6
                 F38H4.9 F48E8.5 F52H3.6 F56C9.1(pp1) F58G1.3 T03F1.5 T16G12.7
                 T23F11.1 T25B9.2 W03D8.2 W09C3.6 Y49E10.3 ZK354.9 ZK938.1
                 fem-2
            DME: CG10138 CG12217(PpV) CG1455(CanA1) CG17291 CG1906 CG2096
                 CG2984(Pp2C1) CG3245(PpN58A) CG5650 CG6571(rdgC)
                 CG6593(Pp1alpha-96A) CG7109 CG8402 CG9156 CG9819
                 CG9842(Pp2B-14D)
            MMU: 101841(Ppm1b) 102666(Ppp5c) 106065(Fin13)
            HSA: 1033(CDKN3) 11266(DUSP12) 1843(DUSP1) 1844(DUSP2) 1846(DUSP4)
                 1847(DUSP5) 1848(DUSP6) 1850(DUSP8) 51723(LOC51723)
                 5470(PPEF2) 5475(PPEF1) 5494(PPM1A) 5495(PPM1B) 5496(PPM1G)
                 5499(PPP1CA) 5500(PPP1CB) 5501(PPP1CC) 5503(PPP1R1B)
                 5504(PPP1R2) 5506(PPP1R3) 5509(PPP1R6) 5515(PPP2CA)
                 5516(PPP2CB) 5517(PPP2CBP) 5518(PPP2R1A) 5519(PPP2R1B)
                 5520(PPP2R2A) 5521(PPP2R2B) 5522(PPP2R2C) 5523(PPP2R3)
                 5530(PPP3CA) 5531(PPP4C) 5532(PPP3CB) 5533(PPP3CC)
                 5534(PPP3R1) 5535(PPP3R2) 5536(PPP5C) 5537(PPP6C) 8493(PPM1D)
                 9647(KIAA0015)
DISEASE     MIM: 114105  Protein phosphatase-3 (formerly 2B), catalytic
                         subunit, alpha isoform
            MIM: 114106  Protein phosphatase-3 (formerly 2B), catalytic
                         subunit, beta isoform
            MIM: 114107  Protein phosphatase-3 (formerly 2B), catalytic
                         subunit, gamma isoform
            MIM: 176875  Protein phosphatase-1, catalytic subunit, alpha
                         isoform
            MIM: 176914  Protein phosphatase-1, catalytic subunit, gamma
                         isoform
            MIM: 176915  Protein phosphatase-2 (formerly 2A), catalytic
                         subunit, alpha isoform
            MIM: 176916  Protein phosphatase-2 (formerly 2A), catalytic
                         subunit, beta isoform
            MIM: 600590  Protein phosphatase-1, catalytic subunit, beta isoform
            MIM: 600658  Protein phosphatase-5, catalytic subunit
            MIM: 602035  Protein phosphatase 4, catalytic subunit
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00125  [LIVMN]-[KR]-G-N-H-E
            PS: PS00383  [LIVMF]-H-C-x(2)-G-x(3)-[STC]-[STAGP]-x-[LIVMFY]
            PS: PS01032  [LIVMFY]-[LIVMFYA]-[GSAC]-[LIVM]-[FYC]-D-G-H-[GAV]
            PS: PS50006  Forkhead-associated (FHA) domain profile
            PS: PS50054  Dual specificity protein phosphatase profile
            PS: PS50056  Tyrosine specific protein phosphatases profile
STRUCTURES  PDB: 1A17  1A6Q  1AUI  1FJM  1JK7  1MKP  1TCO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.16
            ExPASy - ENZYME nomenclature database: 3.1.3.16
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.16
            BRENDA, the Enzyme Database: 3.1.3.16
            SCOP (Structural Classification of Proteins): 3.1.3.16
///
ENTRY       EC 3.1.3.17
NAME        [Phosphorylase] phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [Phosphorylase a] phosphohydrolase
REACTION    [Phosphorylase a] + 4 H2O = 2 [Phosphorylase b] + 4 Orthophosphate
SUBSTRATE   [Phosphorylase a]
            H2O
PRODUCT     [Phosphorylase b]
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.17
            ExPASy - ENZYME nomenclature database: 3.1.3.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.17
            BRENDA, the Enzyme Database: 3.1.3.17
///
ENTRY       EC 3.1.3.18
NAME        Phosphoglycolate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     2-Phosphoglycolate phosphohydrolase
REACTION    2-Phosphoglycolate + H2O = Glycolate + Orthophosphate
SUBSTRATE   2-Phosphoglycolate
            H2O
PRODUCT     Glycolate
            Orthophosphate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b3385(gph)
            ECE: Z4738(gph)
            ECS: ECs4227
            YPE: YPO0156(gph)
            HIN: HI0565(gph)
            PMU: PM1620(gph)
            XFA: XF2470
            VCH: VC2624
            PAE: PA0608 PA3172
            NME: NMB0620 NMB1830
            NMA: NMA0625 NMA0828 NMA1688
            MLO: mlr0528 mlr5413
            SME: SMc00151(gph1) SMc01276(gph2)
            CCR: CC1643 CC2305
            BSU: BG14127(hprP)
            BHA: BH3587
            SAU: SA0513
            SAV: SAV0544
            SPN: SP0104 SP0805
            SPR: spr0093(gph) spr0714(gph)
            UUR: UU115(gph)
            MTU: Rv2233
            BBU: BB0676(gph)
            TPA: TP0407 TP0554
            SYN: sll1349(cbbZp)
            AAE: aq_1342(gph)
            TAC: Ta0845
            TVO: TVG0993131
            HSA: 5240(PGP)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.18
            ExPASy - ENZYME nomenclature database: 3.1.3.18
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.18
            BRENDA, the Enzyme Database: 3.1.3.18
///
ENTRY       EC 3.1.3.19
NAME        Glycerol-2-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Glycerol-2-phosphate phosphohydrolase
REACTION    Glycerol 2-phosphate + H2O = Glycerol + Orthophosphate
SUBSTRATE   Glycerol 2-phosphate
            H2O
PRODUCT     Glycerol
            Orthophosphate
GENES       HSA: 2816(GPB)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.19
            ExPASy - ENZYME nomenclature database: 3.1.3.19
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.19
            BRENDA, the Enzyme Database: 3.1.3.19
///
ENTRY       EC 3.1.3.20
NAME        Phosphoglycerate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Glycerate-2-phosphate phosphohydrolase
REACTION    D-Glycerate 2-phosphate + H2O = D-Glycerate + Orthophosphate
SUBSTRATE   D-Glycerate 2-phosphate
            H2O
PRODUCT     D-Glycerate
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.20
            ExPASy - ENZYME nomenclature database: 3.1.3.20
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.20
            BRENDA, the Enzyme Database: 3.1.3.20
///
ENTRY       EC 3.1.3.21
NAME        Glycerol-1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Glycerol-1-phosphate phosphohydrolase
REACTION    Glycerol 1-phosphate + H2O = Glycerol + Orthophosphate
SUBSTRATE   Glycerol 1-phosphate
            H2O
PRODUCT     Glycerol
            Orthophosphate
COMMENT     The Dunaliella enzyme acts more rapidly on sn-glycerol 1-phosphate
            than on the 3-phosphate. The enzyme from yeast also acts on
            propane-1,2-diol 1-phosphate, but not on a variety of other
            phosphate esters.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.21
            ExPASy - ENZYME nomenclature database: 3.1.3.21
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.21
            BRENDA, the Enzyme Database: 3.1.3.21
///
ENTRY       EC 3.1.3.22
NAME        Mannitol-1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Mannitol-1-phosphate phosphohydrolase
REACTION    D-Mannitol 1-phosphate + H2O = D-Mannitol + Orthophosphate
SUBSTRATE   D-Mannitol 1-phosphate
            H2O
PRODUCT     D-Mannitol
            Orthophosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.22
            ExPASy - ENZYME nomenclature database: 3.1.3.22
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.22
            BRENDA, the Enzyme Database: 3.1.3.22
///
ENTRY       EC 3.1.3.23
NAME        Sugar-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Sugar-phosphate phosphohydrolase
REACTION    Sugar phosphate + H2O = Sugar + Orthophosphate
SUBSTRATE   Sugar phosphate
            H2O
PRODUCT     Sugar
            Orthophosphate
COMMENT     Has a wide specificity, acting on aldohexose 1-phosphates,
            ketohexose 1-phosphate, aldohexose 6-phosphate, ketohexose
            6-phosphate, both phosphate ester bonds of fructose
            1,6-bisphosphate, phosphoric esters of disaccharides and pentose
            and triose phosphates, but at slower rate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.23
            ExPASy - ENZYME nomenclature database: 3.1.3.23
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.23
            BRENDA, the Enzyme Database: 3.1.3.23
///
ENTRY       EC 3.1.3.24
NAME        Sucrose-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Sucrose-6-phosphate phosphohydrolase
REACTION    Sucrose 6-phosphate + H2O = Sucrose + Orthophosphate
SUBSTRATE   Sucrose 6-phosphate
            H2O
PRODUCT     Sucrose
            Orthophosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.24
            ExPASy - ENZYME nomenclature database: 3.1.3.24
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.24
            BRENDA, the Enzyme Database: 3.1.3.24
///
ENTRY       EC 3.1.3.25
NAME        myo-Inositol-1(or 4)-monophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     myo-Inositol-1(or 4)-phosphate phosphahydrolase
REACTION    myo-Inositol 1-phosphate + H2O = myo-Inositol + Orthophosphate
SUBSTRATE   myo-Inositol 1-phosphate
            H2O
            1D-myo-Inositol 1-phosphate
            myo-Inositol 4-phosphate
PRODUCT     myo-Inositol
            Orthophosphate
COMMENT     Acts on both enantiomers of myo-inositol 1-phosphate and
            myo-inositol 4-phosphate. Does not act on inositol bisphosphates,
            trisphosphates or tetrakisphosphates.
PATHWAY     PATH: MAP00521  Streptomycin biosynthesis
            PATH: MAP00562  Inositol phosphate metabolism
GENES       AAE: aq_1983(imp2)
            APE: APE1798
            SSO: SSO2418(imp3)
            STO: ST0547
            DME: CG9391
            HSA: 3612(IMPA1) 3613(IMPA2)
DISEASE     MIM: 602064  Inositol(myo)-1(or 4)-monophosphatase-1
MOTIF       PS: PS00629  [FWV]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-[ST]-x(2)-[FY]-x-
                         [HKRNSTY]
            PS: PS00630  [WV]-D-x-[AC]-[GSA]-[GSAPV]-x-[LIVACP]-[LIV]-[LIVAC]-
                         x(3)-[GH]-[GA]
STRUCTURES  PDB: 1AWB  1DK4  1G0H  1G0I  1IMA  1IMB  1IMC  1IMD  1IME  1IMF  
                 2HHM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.25
            ExPASy - ENZYME nomenclature database: 3.1.3.25
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.25
            BRENDA, the Enzyme Database: 3.1.3.25
            SCOP (Structural Classification of Proteins): 3.1.3.25
///
ENTRY       EC 3.1.3.26
NAME        6-Phytase
            Phytase
            Phytate 6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     myo-Inositol-hexakisphosphate 6-phosphohydrolase
REACTION    myo-Inositol hexakisphosphate + H2O =
            1L-myo-Inositol 1,2,3,4,5-pentakisphosphate + Orthophosphate
SUBSTRATE   myo-Inositol hexakisphosphate
            H2O
PRODUCT     1L-myo-Inositol 1,2,3,4,5-pentakisphosphate
            Orthophosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       ECO: b0980(appA)
            ECE: Z1397(appA)
            ECS: ECs1136
MOTIF       PS: PS00616  [LIVM]-x(2)-[LIVMA]-x(2)-[LIVM]-x-R-H-[GN]-x-R-x-[PAS]
            PS: PS00778  [LIVMF]-x-[LIVMFAG]-x(2)-[STAGI]-H-D-[STANQ]-x-[LIVM]-
                         x(2)-[LIVMFY]-x(2)-[STA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.26
            ExPASy - ENZYME nomenclature database: 3.1.3.26
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.26
            BRENDA, the Enzyme Database: 3.1.3.26
///
ENTRY       EC 3.1.3.27
NAME        Phosphatidylglycerophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Phosphatidylglycerophosphate phosphohydrolase
REACTION    Phosphatidylglycerophosphate + H2O = Phosphatidylglycerol +
            Orthophosphate
SUBSTRATE   Phosphatidylglycerophosphate
            H2O
PRODUCT     Phosphatidylglycerol
            Orthophosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b0418(pgpA) b1278(pgpB)
            ECE: Z0520(pgpA) Z2529(pgpB)
            ECS: ECs0471 ECs1851
            YPE: YPO2223(pgpB) YPO3179(pgpA)
            HIN: HI0211(pgpB) HI1306(pgpA)
            PMU: PM0676(pdpB) PM0728(pgpA)
            VCH: VC2265
            PAE: PA4050
            NME: NMB0386
            NMA: NMA2102(pgpA)
            HPY: HP0737
            HPJ: jhp0674
            CJE: Cj1610(pgpA)
            RPR: RP750(pgpA)
            RCO: RC1161(pgpA)
            AAE: aq_314
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.27
            ExPASy - ENZYME nomenclature database: 3.1.3.27
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.27
            BRENDA, the Enzyme Database: 3.1.3.27
///
ENTRY       EC 3.1.3.28
NAME        ADPphosphoglycerate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     3-(ADP)-2-phosphoglycerate phosphohydrolase
REACTION    3-(ADP)-2-phosphoglycerate + H2O = 3-(ADP)-glycerate +
            Orthophosphate
SUBSTRATE   3-(ADP)-2-phosphoglycerate
            H2O
            2,3-Bisphosphoglycerate
PRODUCT     3-(ADP)-glycerate
            Orthophosphate
            3-Phosphoglycerate
COMMENT     Also acts on 2,3-bisphosphoglycerate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.28
            ExPASy - ENZYME nomenclature database: 3.1.3.28
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.28
            BRENDA, the Enzyme Database: 3.1.3.28
///
ENTRY       EC 3.1.3.29
NAME        N-Acylneuraminate-9-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     N-Acylneuraminate-9-phosphate phosphohydrolase
REACTION    N-Acylneuraminate 9-phosphate + H2O = N-Acylneuraminate +
            Orthophosphate
SUBSTRATE   N-Acylneuraminate 9-phosphate
            H2O
PRODUCT     N-Acylneuraminate
            Orthophosphate
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.29
            ExPASy - ENZYME nomenclature database: 3.1.3.29
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.29
            BRENDA, the Enzyme Database: 3.1.3.29
///
ENTRY       EC 3.1.3.30
NAME        Deleted entry
            3'-Phosphoadenylylsulfate 3'-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
COMMENT     Deleted entry. Now included with EC 3.1.3.7,
            3'(2'),5'-Bisphosphate nucleotidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.30
            ExPASy - ENZYME nomenclature database: 3.1.3.30
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.30
            BRENDA, the Enzyme Database: 3.1.3.30
///
ENTRY       EC 3.1.3.31
NAME        Nucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Nucleotide phosphohydrolase
REACTION    a Nucleotide + H2O = a Nucleoside + Orthophosphate
SUBSTRATE   Nucleotide
            H2O
PRODUCT     Nucleoside
            Orthophosphate
COMMENT     A wide specificity for 2',3'- and 5'- nucleotides; also hydrolyses
            glycerol phosphate and 4-nitrophenyl phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.31
            ExPASy - ENZYME nomenclature database: 3.1.3.31
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.31
            BRENDA, the Enzyme Database: 3.1.3.31
///
ENTRY       EC 3.1.3.32
NAME        Polynucleotide 3'-phosphatase
            2'(3')-Polynucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Polynucleotide 3'-phosphohydrolase
REACTION    a 3'-Phosphopolynucleotide + H2O = a Polynucleotide +
            Orthophosphate
SUBSTRATE   3'-Phosphopolynucleotide
            H2O
PRODUCT     Polynucleotide
            Orthophosphate
COMMENT     Also hydrolyses nucleoside 2'-, 3'- and 5'-monophosphates, but
            only 2'- and 3'-phosphopolynucleotides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.32
            ExPASy - ENZYME nomenclature database: 3.1.3.32
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.32
            BRENDA, the Enzyme Database: 3.1.3.32
///
ENTRY       EC 3.1.3.33
NAME        Polynucleotide 5'-phosphatase
            5'-Polynucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Polynucleotide 5'-phosphohydrolase
REACTION    a 5'-Phosphopolynucleotide + H2O = a Polynucleotide +
            Orthophosphate
SUBSTRATE   5'-Phosphopolynucleotide
            H2O
PRODUCT     Polynucleotide
            Orthophosphate
COMMENT     Does not act on nucleoside monophosphates. Induced in E. coli by
            T-even phages.
GENES       SCE: YMR180C(CTL1) YPL228W(CET1)
            CEL: C03D6.3(cel-1)
            HSA: 8732(RNGTT)
STRUCTURES  PDB: 1D8H  1I9S  1I9T  1D8I  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.33
            ExPASy - ENZYME nomenclature database: 3.1.3.33
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.33
            BRENDA, the Enzyme Database: 3.1.3.33
            SCOP (Structural Classification of Proteins): 3.1.3.33
///
ENTRY       EC 3.1.3.34
NAME        Deoxynucleotide 3'-phosphatase
            3'-Deoxynucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Deoxyribonucleotide 3'-phosphohydrolase
REACTION    a Deoxynucleoside 3'-phosphate + H2O = a Deoxynucleoside +
            Orthophosphate
SUBSTRATE   Deoxynucleoside 3'-phosphate
            H2O
PRODUCT     Deoxynucleoside
            Orthophosphate
COMMENT     Also catalyses the selective removal of 3'-phosphate groups from
            DNA and oligodeoxynucleotides. Induced in E. coli by T-even
            phages.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.34
            ExPASy - ENZYME nomenclature database: 3.1.3.34
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.34
            BRENDA, the Enzyme Database: 3.1.3.34
///
ENTRY       EC 3.1.3.35
NAME        Thymidylate 5'-phosphatase
            Thymidylate 5'-nucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Thymidylate 5'-phosphohydrolase
REACTION    Thymidylate + H2O = Thymidine + Orthophosphate
SUBSTRATE   Thymidylate
            H2O
PRODUCT     Thymidine
            Orthophosphate
COMMENT     Acts on 5-methyl-dCMP and on TMP, but more slowly than on dTMP.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.35
            ExPASy - ENZYME nomenclature database: 3.1.3.35
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.35
            BRENDA, the Enzyme Database: 3.1.3.35
///
ENTRY       EC 3.1.3.36
NAME        Phosphatidylinositol-bisphosphatase
            Triphosphoinositide phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase
REACTION    Phosphatidyl-myo-inositol 4,5-bisphosphate + H2O =
            Phosphatidylinositol 4-phosphate + Orthophosphate
SUBSTRATE   Phosphatidyl-myo-inositol 4,5-bisphosphate
            H2O
PRODUCT     Phosphatidylinositol 4-phosphate
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.36
            ExPASy - ENZYME nomenclature database: 3.1.3.36
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.36
            BRENDA, the Enzyme Database: 3.1.3.36
///
ENTRY       EC 3.1.3.37
NAME        Sedoheptulose-bisphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Sedoheptulose-1,7-bisphosphate 1-phosphohydrolase
REACTION    Sedoheptulose 1,7-bisphosphate + H2O = Sedoheptulose 7-phosphate +
            Orthophosphate
SUBSTRATE   Sedoheptulose 1,7-bisphosphate
            H2O
PRODUCT     Sedoheptulose 7-phosphate
            Orthophosphate
PATHWAY     PATH: MAP00710  Carbon fixation
MOTIF       PS: PS00124  [AG]-[RK]-[LI]-x(1,2)-[LIV]-[FY]-E-x(2)-P-[LIVM]-[GSA]
STRUCTURES  PDB: 1EOX  1EOY  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.37
            ExPASy - ENZYME nomenclature database: 3.1.3.37
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.37
            BRENDA, the Enzyme Database: 3.1.3.37
            SCOP (Structural Classification of Proteins): 3.1.3.37
///
ENTRY       EC 3.1.3.38
NAME        3-Phosphoglycerate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Glycerate-3-phosphate phosphohydrolase
REACTION    D-Glycerate 3-phosphate + H2O = D-Glycerate + Orthophosphate
SUBSTRATE   D-Glycerate 3-phosphate
            H2O
PRODUCT     D-Glycerate
            Orthophosphate
COMMENT     Wide specificity, but 3-phosphoglycerate is the best substrate.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.38
            ExPASy - ENZYME nomenclature database: 3.1.3.38
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.38
            BRENDA, the Enzyme Database: 3.1.3.38
///
ENTRY       EC 3.1.3.39
NAME        Streptomycin-6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Streptomycin-6-phosphate phosphohydrolase
REACTION    Streptomycin 6-phosphate + H2O = Streptomycin + Orthophosphate
SUBSTRATE   Streptomycin 6-phosphate
            H2O
            Dihydrostreptomycin 3'alpha,6-bisphosphate
            Streptidine 6-phosphate
PRODUCT     Streptomycin
            Orthophosphate
            Dihydrostreptomycin 3'alpha-phosphate
            Streptidine
COMMENT     Also acts on dihydrostreptomycin 3'alpha,6-bisphosphate and
            streptidine 6-phosphate.
MOTIF       PS: PS00123  [IV]-x-D-S-[GAS]-[GASC]-[GAST]-[GA]-T
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.39
            ExPASy - ENZYME nomenclature database: 3.1.3.39
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.39
            BRENDA, the Enzyme Database: 3.1.3.39
///
ENTRY       EC 3.1.3.40
NAME        Guanidinodeoxy-scyllo-inositol-4-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     1-Guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase
REACTION    1-Guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O =
            1-Guanidino-1-deoxy-scyllo-inositol + Orthophosphate
SUBSTRATE   1-Guanidino-1-deoxy-scyllo-inositol 4-phosphate
            H2O
PRODUCT     1-Guanidino-1-deoxy-scyllo-inositol
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.40
            ExPASy - ENZYME nomenclature database: 3.1.3.40
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.40
            BRENDA, the Enzyme Database: 3.1.3.40
///
ENTRY       EC 3.1.3.41
NAME        4-Nitrophenylphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     4-Nitrophenylphosphate phosphohydrolase
REACTION    4-Nitrophenyl phosphate + H2O = 4-Nitrophenol + Orthophosphate
SUBSTRATE   4-Nitrophenyl phosphate
            H2O
PRODUCT     4-Nitrophenol
            Orthophosphate
COMMENT     A number of other substances including phenyl phosphate,
            4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate
            are not substrates.
GENES       PAB: PAB1056
            SCE: YDL236W(PHO13)
            SPO: PHO2(pho2)
            CEL: C53A3.2 F44E7.2 K09H11.7
            DME: CG10352 CG11291 CG15739 CG2077 CG2680(EG:100G10.4) CG5567
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.41
            ExPASy - ENZYME nomenclature database: 3.1.3.41
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.41
            BRENDA, the Enzyme Database: 3.1.3.41
///
ENTRY       EC 3.1.3.42
NAME        [Glycogen-synthase-D]-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D]
            $ phosphohydrolase
REACTION    [Glycogen-synthase D] + H2O = [Glycogen-synthase I] +
            Orthophosphate
SUBSTRATE   [Glycogen-synthase D]
            H2O
PRODUCT     [Glycogen-synthase I]
            Orthophosphate
COMMENT     The product is EC 2.4.1.11.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.42
            ExPASy - ENZYME nomenclature database: 3.1.3.42
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.42
            BRENDA, the Enzyme Database: 3.1.3.42
///
ENTRY       EC 3.1.3.43
NAME        [Pyruvate dehydrogenase (lipoamide)]-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [Pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase
REACTION    [Pyruvate dehydrogenase (lipoamide)] phosphate + H2O =
            [Pyruvate dehydrogenase (lipoamide)] + Orthophosphate
SUBSTRATE   [Pyruvate dehydrogenase (lipoamide)] phosphate
            H2O
PRODUCT     [Pyruvate dehydrogenase (lipoamide)]
            Orthophosphate
COMMENT     A mitochondrial enzyme associated with EC 1.2.4.1 in the pyruvate
            dehydrogenase complex.
GENES       HSA: 54704(PDP) 5497(PPM2C)
MOTIF       PS: PS01032  [LIVMFY]-[LIVMFYA]-[GSAC]-[LIVM]-[FYC]-D-G-H-[GAV]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.43
            ExPASy - ENZYME nomenclature database: 3.1.3.43
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.43
            BRENDA, the Enzyme Database: 3.1.3.43
///
ENTRY       EC 3.1.3.44
NAME        [Acetyl-CoA carboxylase]-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [Acetyl-CoA:carbon-dioxide ligase (ADP-forming)]-phosphate
            $ phosphohydrolase
REACTION    [Acetyl-CoA carboxylase] phosphate + H2O =
            [Acetyl-CoA carboxylase] + Orthophosphate
SUBSTRATE   [Acetyl-CoA carboxylase] phosphate
            H2O
PRODUCT     [Acetyl-CoA carboxylase]
            Orthophosphate
COMMENT     Simultaneously dephosphorylates and activates EC 6.4.1.2. Acts
            similarly on EC 1.1.1.88, 2.4.1.1 and 2.4.1.11, and
            dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate.
            Not identical with EC 3.1.3.17 or 3.1.3.43.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.44
            ExPASy - ENZYME nomenclature database: 3.1.3.44
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.44
            BRENDA, the Enzyme Database: 3.1.3.44
///
ENTRY       EC 3.1.3.45
NAME        3-Deoxy-manno-octulosonate-8-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     3-Deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase
REACTION    3-Deoxy-D-manno-octulosonate 8-phosphate + H2O =
            3-Deoxy-D-manno-octulosonate + Orthophosphate
SUBSTRATE   3-Deoxy-D-manno-octulosonate 8-phosphate
            H2O
PRODUCT     3-Deoxy-D-manno-octulosonate
            Orthophosphate
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.45
            ExPASy - ENZYME nomenclature database: 3.1.3.45
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.45
            BRENDA, the Enzyme Database: 3.1.3.45
///
ENTRY       EC 3.1.3.46
NAME        Fructose-2,6-bisphosphate 2-phosphatase
            Fructose-2,6-bisphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Fructose-2,6-bisphosphate 2-phosphohydrolase
REACTION    D-Fructose 2,6-bisphosphate + H2O = D-Fructose 6-phosphate +
            Orthophosphate
SUBSTRATE   D-Fructose 2,6-bisphosphate
            H2O
PRODUCT     D-Fructose 6-phosphate
            Orthophosphate
COMMENT     The enzyme copurifies with EC 2.7.1.105. cf. EC 3.1.3.54.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       SCE: YJL155C(FBP26)
            SPO: SPAC732.02C(spac732.02c)
            CEL: K02B2.1
            HSA: 5207(PFKFB1) 5208(PFKFB2) 5209(PFKFB3) 5210(PFKFB4)
DISEASE     MIM: 311790  Fructose-2,6-bisphosphatase
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
STRUCTURES  PDB: 1FBT  2BIF  3BIF  1BIF  1TIP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.46
            ExPASy - ENZYME nomenclature database: 3.1.3.46
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.46
            BRENDA, the Enzyme Database: 3.1.3.46
            SCOP (Structural Classification of Proteins): 3.1.3.46
///
ENTRY       EC 3.1.3.47
NAME        [Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase
            Reductase phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [Hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate
            $ phosphohydrolase
REACTION    [Hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O =
            [Hydroxymethylglutaryl-CoA reductase (NADPH)] + Orthophosphate
SUBSTRATE   [Hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
            H2O
PRODUCT     [Hydroxymethylglutaryl-CoA reductase (NADPH)]
            Orthophosphate
COMMENT     Acts on the product of the reaction catalysed by EC 2.7.1.109,
            simultaneously dephosphorylating and activating EC 1.1.1.34.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.47
            ExPASy - ENZYME nomenclature database: 3.1.3.47
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.47
            BRENDA, the Enzyme Database: 3.1.3.47
///
ENTRY       EC 3.1.3.48
NAME        Protein-tyrosine-phosphatase
            Phosphotyrosine phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Protein-tyrosine-phosphate phosphohydrolase
REACTION    Protein tyrosine phosphate + H2O = Protein tyrosine +
            Orthophosphate
SUBSTRATE   Protein tyrosine phosphate
            H2O
PRODUCT     Protein tyrosine
            Orthophosphate
COMMENT     Dephosphorylates O-phosphotyrosine groups in phosphoproteins,
            such as the products of EC 2.7.1.112.
            Phosphoprotein phosphatase (cf. EC 3.1.3.16) is a group of enzymes
            removing the serine- or threonine-bound phosphate group.
GENES       ECO: b0982(yccY) b2061(wzb)
            ECE: Z1399(yccY) Z3226(wzb)
            ECS: ECs1138 ECs2866
            PMU: PM1017 PM1569(yfkJ)
            XFA: XF2298
            VCH: VC0916 VC1041
            PAE: PA2978
            NME: NMB1267
            NMA: NMA1472
            CJE: Cj1258
            MLO: mll4349
            CCR: CC2368
            BSU: BG10941(ywlE) BG12926(yfkJ)
            BHA: BH2238 BH3769
            SAU: SA1697 SA1917
            SAV: SAV1866 SAV2102
            LLA: L67624(ptpL)
            SPY: SPy0039
            SPN: SP2028
            CAC: CAC2881
            MTU: Rv2234(ptpA)
            MTC: MT2293
            SYN: slr0328
            SCE: YBR276C(PPS1) YDL230W(PTP1) YER075C(PTP3) YFR028C(CDC14)
                 YIL113W(YIL113W) YIR026C(YVH1) YMR036C(MIH1) YNL053W(MSG5)
                 YOR208W(PTP2) YPR073C(LTP1)
            SPO: CDC25(cdc25) PYP1(pyp1) PYP2(pyp2) PYP3(pyp3)
                 SPAC1782.09C(spac1782.09c) STP1(stp1)
            CEL: F08B1.1(vhp-1) F16B4.8 F54C8.4 F59G1.5(stp-1) ptp-1
            DME: CG10975(Ptp69D) CG1228 CG1395(stg) CG1817(Ptp10D) CG2005
                 CG3954_1 CG4965(twe) CG4993(PRL-1) CG6899(Ptp4E) CG7134
                 CG9181(Ptp61F) CG9181_1(Ptp61F) CG9493 CG9856(PTP-ER)
            MMU: 102694(Ptprm) 102765(Ptprn) 103198(Cdc25a) 103310(Ptprk)
                 104574(Ptprj) 108410(Ptpn18) 88350(Cdc25c) 96055(Hcph)
                 97806(Ptpn2) 97807(Ptpn5) 97808(Ptpra) 97809(Ptprb)
                 97810(Ptprc) 97812(Ptprd) 97814(Ptprg) 99701(Cdc25b)
            HSA: 10076(PTPRU) 1033(CDKN3) 11099(PTPN21) 11221(DUSP10)
                 1843(DUSP1) 1844(DUSP2) 1845(DUSP3) 1846(DUSP4) 1847(DUSP5)
                 1848(DUSP6) 1850(DUSP8) 1852(DUSP9) 52(ACP1) 5728(PTEN)
                 5770(PTPN1) 5771(PTPN2) 5774(PTPN3) 5775(PTPN4) 5776(PTPN5)
                 5777(PTPN6) 5778(PTPN7) 5780(PTPN9) 5781(PTPN11) 5782(PTPN12)
                 5784(PTPN14) 5786(PTPRA) 5787(PTPRB) 5788(PTPRC) 5789(PTPRD)
                 5791(PTPRE) 5792(PTPRF) 5793(PTPRG) 5795(PTPRJ) 5796(PTPRK)
                 5797(PTPRM) 5800(PTPRO) 5803(PTPRZ1) 8446(DUSP11) 993(CDC25A)
                 994(CDC25B) 995(CDC25C)
DISEASE     MIM: 116947  Cell division cycle 25A
            MIM: 116949  Cell division cycle 25B
            MIM: 151460  Protein tyrosine phosphatase, receptor type, c
                         polypeptide
            MIM: 157680  Cell division cycle 25C
            MIM: 171500  Acid phosphatase 1, soluble
            MIM: 176876  Protein tyrosine phosphatase, non-receptor type 11
            MIM: 176879  Protein tyrosine phosphatase, non-receptor type 5
                         (striatum-enriched)
            MIM: 176882  Protein tyrosine phosphatase, receptor type, beta
                         polypeptide
            MIM: 176883  Protein tyrosine phosphatase, non-receptor type 6
            MIM: 176884  Protein tyrosine phosphatase, receptor type, alpha
                         polypeptide
            MIM: 176885  Protein tyrosine phosphatase, non-receptor type 1
            MIM: 176886  Protein tyrosine phosphatase, receptor type, gamma
                         polypeptide
            MIM: 176887  Protein tyrosine phosphatase, non-receptor type 2
            MIM: 176888  Protein tyrosine phosphatase, receptor type, mu
                         polypeptide
            MIM: 179590  Protein tyrosine phosphatase, receptor type, f
                         polypeptide
            MIM: 600079  Protein tyrosine phosphatase, non-receptor type 12
            MIM: 600183  Dual specificity phosphatase-3 (vaccinia virus
                         phosphatase
            MIM: 600714  Dual specificity phosphatase-1
            MIM: 600926  Protein tyrosine phosphatase, receptor type, epsilon
            MIM: 601598  Protein tyrosine phosphatase, receptor type, delta
                         polypeptide
            MIM: 602545  Protein-tyrosine phosphatase, receptor type, kappa
MOTIF       PS: PS00383  [LIVMF]-H-C-x(2)-G-x(3)-[STC]-[STAGP]-x-[LIVMFY]
            PS: PS00660  W-[LIV]-x(3)-[KRQ]-x-[LIVM]-x(2)-[QH]-x(0,2)-[LIVMF]-
                         x(6,8)-[LIVMF]-x(3,5)-F-[FY]-x(2)-[DENS]
            PS: PS00661  [HYW]-x(9)-[DENQSTV]-[SA]-x(3)-[FY]-[LIVM]-x(2)-[ACV]-
                         x(2)-[LM]-x(2)-[FY]-G-x-[DENQST]-[LIVMFYS]
            PS: PS00740  G-x-[LIVMFY](2)-x(3)-[STA]-x(10,11)-[LV]-x(4)-[LIVMF]-
                         x(6,7)-C-[LIVM]-x-F-x-[LIVMFY]-x(3)-[GSC]
            PS: PS50001  Src homology 2 (SH2) domain profile
            PS: PS50054  Dual specificity protein phosphatase profile
            PS: PS50055  PTP type protein phosphatase profile
            PS: PS50056  Tyrosine specific protein phosphatases profile
            PS: PS50057  Band 4.1 family domain profile
            PS: PS50060  MAM domain profile
STRUCTURES  PDB: 1G7G  1AYC  1AYB  1AYA  1BZH  1A5Y  1BZJ  1BZC  1G7F  1C83  
                 1C84  1AAX  1C85  1C86  1GFY  1I57  1C87  1C88  1CWR  1D1P  
                 1D1Q  1D2A  1D5R  1DG9  1ECV  1EEN  1EEO  1I8G  1JLN  1LAR  
                 1MKP  1PHR  1PTT  1PTU  1PTV  1PTY  1QB0  1RPM  1VHR  1YFO  
                 1YPT  1YTN  1YTS  1YTW  2HNP  2HNQ  2SHP  3PDZ  1HUF  1FPR  
                 1FPZ  1FQ1  1G1F  1G1G  1G1H  1GWZ  1C25  1AYD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.48
            ExPASy - ENZYME nomenclature database: 3.1.3.48
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.48
            BRENDA, the Enzyme Database: 3.1.3.48
            SCOP (Structural Classification of Proteins): 3.1.3.48
///
ENTRY       EC 3.1.3.49
NAME        [Pyruvate kinase]-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [ATP:pyruvate 2-O-phosphotransferase]-phosphate phosphohydrolase
REACTION    [Pyruvate kinase] phosphate + H2O = [Pyruvate kinase] +
            Orthophosphate
SUBSTRATE   [Pyruvate kinase] phosphate
            H2O
PRODUCT     [Pyruvate kinase]
            Orthophosphate
COMMENT     Simultaneously dephosphorylates and activates EC 2.7.1.40 which
            has been inactivated by protein kinase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.49
            ExPASy - ENZYME nomenclature database: 3.1.3.49
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.49
            BRENDA, the Enzyme Database: 3.1.3.49
///
ENTRY       EC 3.1.3.50
NAME        Sorbitol-6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Sorbitol-6-phosphate phosphohydrolase
REACTION    Sorbitol 6-phosphate + H2O = Sorbitol + Orthophosphate
SUBSTRATE   Sorbitol 6-phosphate
            H2O
PRODUCT     Sorbitol
            Orthophosphate
COMMENT     Acts, very slowly, on hexose 6-phosphates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.50
            ExPASy - ENZYME nomenclature database: 3.1.3.50
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.50
            BRENDA, the Enzyme Database: 3.1.3.50
///
ENTRY       EC 3.1.3.51
NAME        Dolichyl-phosphatase
            Dolichol phosphate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Dolichyl-phosphate phosphohydrolase
REACTION    Dolichyl phosphate + H2O = Dolichol + Orthophosphate
SUBSTRATE   Dolichyl phosphate
            H2O
PRODUCT     Dolichol
            Orthophosphate
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.51
            ExPASy - ENZYME nomenclature database: 3.1.3.51
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.51
            BRENDA, the Enzyme Database: 3.1.3.51
///
ENTRY       EC 3.1.3.52
NAME        [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase
            Branched-chain oxo-acid dehydrogenase phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate
            $ phosphohydrolase
REACTION    [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate +
            H2O = [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] +
            Orthophosphate
SUBSTRATE   [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate
            H2O
PRODUCT     [3-Methyl-2-oxobutanoate dehydrogenase (lipoamide)]
            Orthophosphate
COMMENT     A mitochondrial enzyme associated with the 3-methyl-2-oxobutanoate
            activates EC 1.2.4.4 which has been inactivated by
            phosphorylation.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.52
            ExPASy - ENZYME nomenclature database: 3.1.3.52
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.52
            BRENDA, the Enzyme Database: 3.1.3.52
///
ENTRY       EC 3.1.3.53
NAME        Myosin-light-chain-phosphatase
            Myosin light chain kinase phosphatase
            Myosin phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     [Myosin-light-chain]-phosphate phosphohydrolase
REACTION    Myosin light-chain phosphate + H2O = Myosin light chain +
            Orthophosphate
SUBSTRATE   Myosin light-chain phosphate
            H2O
PRODUCT     Myosin lignt chain
            Orthophosphate
COMMENT     The enzyme is composed of three subunits. The holoenzyme
            dephosphorylates myosin light chains and myosin-light-chain
            kinase, but not myosin; the catalytic subunit acts on all three
            substrates.
GENES       HSA: 4660(MYPT2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.53
            ExPASy - ENZYME nomenclature database: 3.1.3.53
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.53
            BRENDA, the Enzyme Database: 3.1.3.53
///
ENTRY       EC 3.1.3.54
NAME        Fructose-2,6-bisphosphate 6-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-Fructose-2,6-bisphosphate 6-phosphohydrolase
REACTION    D-Fructose 2,6-bisphosphate + H2O = D-Fructose 2-phosphate +
            Orthophosphate
SUBSTRATE   D-Fructose 2,6-bisphosphate
            H2O
PRODUCT     D-Fructose 2-phosphate
            Orthophosphate
COMMENT     cf. EC 3.1.3.46.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.54
            ExPASy - ENZYME nomenclature database: 3.1.3.54
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.54
            BRENDA, the Enzyme Database: 3.1.3.54
///
ENTRY       EC 3.1.3.55
NAME        Caldesmon-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Caldesmon-phosphate phosphohydrolase
REACTION    Caldesmon phosphate + H2O = Caldesmon + Orthophosphate
SUBSTRATE   Caldesmon phosphate
            H2O
PRODUCT     Caldesmon
            Orthophosphate
COMMENT     Dephosphorylation activates the calmodulin- and actin-binding
            ability of the protein caldesmon.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.55
            ExPASy - ENZYME nomenclature database: 3.1.3.55
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.55
            BRENDA, the Enzyme Database: 3.1.3.55
///
ENTRY       EC 3.1.3.56
NAME        Inositol-1,4,5-trisphosphate 5-phosphatase
            Inositol trisphosphate phosphomonoesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,4,5-trisphosphate 5-phosphohydrolase
REACTION    D-myo-Inositol 1,4,5-trisphosphate + H2O =
            D-myo-Inositol 1,4-bisphosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,4,5-trisphosphate
            H2O
            1D-myo-Inositol 1,3,4,5-tetrakisphosphate
PRODUCT     D-myo-Inositol 1,4-bisphosphate
            Orthophosphate
            1D-myo-Inositol 1,3,4-trisphosphate
COMMENT     Type I enzyme (but not type II enzyme) also hydrolyses inositol
            1,3,4,5-tetrakisphosphate at the 5-position; neither enzyme acts
            on inositol 1,4-bisphosphate or inositol 1,3,4-trisphosphate.
            cf. EC 3.1.3.61.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       CEL: C09B8.1
            DME: CG3573(EG:86E4.5) CG6562
            HSA: 3633(INPP5B) 3636(INPPL1) 4952(OCRL) 8867(SYNJ1)
DISEASE     MIM: 147264  Inositol polyphosphate-5-phosphatase, 75kD
            MIM: 309000  Oculocerebrorenal syndrome of Lowe
            MIM: 600829  Inositol polyphosphate phosphatase-like 1
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.56
            ExPASy - ENZYME nomenclature database: 3.1.3.56
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.56
            BRENDA, the Enzyme Database: 3.1.3.56
///
ENTRY       EC 3.1.3.57
NAME        Inositol-1,4-bisphosphate 1-phosphatase
            Inositol-polyphosphate 1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,4-bisphosphate 1-phosphohydrolase
REACTION    D-myo-Inositol 1,4-bisphosphate + H2O = D-myo-Inositol 4-phosphate
            + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,4-bisphosphate
            H2O
            1D-myo-Inositol 1,3,4-trisphosphate
PRODUCT     D-myo-Inositol 4-phosphate
            Orthophosphate
            1D-myo-Inositol 3,4-bisphosphate
COMMENT     The enzyme acts on inositol 1,4-bisphosphate and inositol
            1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with
            similar Vmax for both substrates, but with a five times higher
            affinity for the bisphosphate. Does not act on inositol
            1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-
            tetrakisphosphate.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       DME: CG3028(Ipp)
            MMU: 104848(Inpp1)
            HSA: 3628(INPP1)
DISEASE     MIM: 147263  Inositol polyphosphate-1-phosphatase
MOTIF       PS: PS00629  [FWV]-x(0,1)-[LIVM]-D-P-[LIVM]-D-[SG]-[ST]-x(2)-[FY]-x-
                         [HKRNSTY]
            PS: PS00630  [WV]-D-x-[AC]-[GSA]-[GSAPV]-x-[LIVACP]-[LIV]-[LIVAC]-
                         x(3)-[GH]-[GA]
STRUCTURES  PDB: 1INP  1JP4  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.57
            ExPASy - ENZYME nomenclature database: 3.1.3.57
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.57
            BRENDA, the Enzyme Database: 3.1.3.57
            SCOP (Structural Classification of Proteins): 3.1.3.57
///
ENTRY       EC 3.1.3.58
NAME        Sugar-terminal-phosphatase
            Xylitol-5-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Sugar-omega-phosphate phosphohydrolase
REACTION    D-Glucose 6-phosphate + H2O = D-Glucose + Orthophosphate
SUBSTRATE   D-Glucose 6-phosphate
            H2O
PRODUCT     D-Glucose
            Orthophosphate
COMMENT     Acts on sugars and polyols phosphorylated on the terminal carbon,
            with a preference for sugars with a D-erythro-configuration, e.g.
            good substrates are glucose 6-phosphate, mannose 6-phosphate,
            6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.58
            ExPASy - ENZYME nomenclature database: 3.1.3.58
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.58
            BRENDA, the Enzyme Database: 3.1.3.58
///
ENTRY       EC 3.1.3.59
NAME        Alkylacetylglycerophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     1-Alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase
REACTION    1-Alkyl-2-acetyl-sn-glycero-3-phosphate + H2O =
            1-Alkyl-2-acetyl-sn-glycerol + Orthophosphate
SUBSTRATE   1-Alkyl-2-acetyl-sn-glycero-3-phosphate
            H2O
PRODUCT     1-Alkyl-2-acetyl-sn-glycerol
            Orthophosphate
COMMENT     Involved in the biosynthesis of thrombocyte activating factor in
            animal tissues.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.59
            ExPASy - ENZYME nomenclature database: 3.1.3.59
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.59
            BRENDA, the Enzyme Database: 3.1.3.59
///
ENTRY       EC 3.1.3.60
NAME        Phosphoenolpyruvate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Phosphoenolpyruvate phosphohydrolase
REACTION    Phosphoenolpyruvate + H2O = Pyruvate + Orthophosphate
SUBSTRATE   Phosphoenolpyruvate
            H2O
PRODUCT     Pyruvate
            Orthophosphate
COMMENT     Also acts, more slowly, on a wide range of other monophosphates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.60
            ExPASy - ENZYME nomenclature database: 3.1.3.60
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.60
            BRENDA, the Enzyme Database: 3.1.3.60
///
ENTRY       EC 3.1.3.61
NAME        Inositol-1,4,5-trisphosphate 1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,4,5-trisphosphate 1-phosphohydrolase
REACTION    D-myo-Inositol 1,4,5-trisphosphate + H2O =
            D-myo-Inositol 4,5-bisphosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,4,5-trisphosphate
            H2O
PRODUCT     D-myo-Inositol 4,5-bisphosphate
            Orthophosphate
COMMENT     cf. EC 1.3.1.56.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.61
            ExPASy - ENZYME nomenclature database: 3.1.3.61
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.61
            BRENDA, the Enzyme Database: 3.1.3.61
///
ENTRY       EC 3.1.3.62
NAME        Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,3,5,6-tetrakisphosphate 3-phosphohydrolase
REACTION    D-myo-Inositol 1,3,4,5-tetrakisphosphate + H2O =
            D-myo-Inositol 1,4,5-trisphosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,3,4,5-tetrakisphosphate
            H2O
PRODUCT     D-myo-Inositol 1,4,5-trisphosphate
            Orthophosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.62
            ExPASy - ENZYME nomenclature database: 3.1.3.62
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.62
            BRENDA, the Enzyme Database: 3.1.3.62
///
ENTRY       EC 3.1.3.63
NAME        2-Carboxy-D-arabinitol-1-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     2-Carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase
REACTION    2-Carboxy-D-arabinitol 1-phosphate + H2O =
            2-Carboxy-D-arabinitol + Orthophosphate
SUBSTRATE   2-Carboxy-D-arabinitol 1-phosphate
            H2O
PRODUCT     2-Carboxy-D-arabinitol
            Orthophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.63
            ExPASy - ENZYME nomenclature database: 3.1.3.63
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.63
            BRENDA, the Enzyme Database: 3.1.3.63
///
ENTRY       EC 3.1.3.64
NAME        Phosphatidylinositol-3-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     Phosphatidylinositol-3-phosphate 3-phosphohydrolase
REACTION    Phosphatidylinositol 3-phosphate + H2O =
            Phosphatidylinositol + Orthophosphate
SUBSTRATE   Phosphatidylinositol 3-phosphate
            H2O
PRODUCT     Phosphatidylinositol
            Orthophosphate
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.64
            ExPASy - ENZYME nomenclature database: 3.1.3.64
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.64
            BRENDA, the Enzyme Database: 3.1.3.64
///
ENTRY       EC 3.1.3.65
NAME        Inositol-1,3-bisphosphate 3-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-1,3-bisphosphate 3-phosphohydrolase
REACTION    D-myo-Inositol 1,3-bisphosphate + H2O =
            1D-myo-Inositol 1-phosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 1,3-bisphosphate
            H2O
PRODUCT     1D-myo-Inositol 1-phosphate
            Orthophosphate
COMMENT     Mg2+-independent; different from EC 3.1.3.57, 3.1.3.61 and
            3.1.3.66.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.65
            ExPASy - ENZYME nomenclature database: 3.1.3.65
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.65
            BRENDA, the Enzyme Database: 3.1.3.65
///
ENTRY       EC 3.1.3.66
NAME        Inositol-3,4-bisphosphate 4-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
SYSNAME     D-myo-Inositol-3,4-bisphosphate 4-phosphohydrolase
REACTION    D-myo-Inositol 3,4-bisphosphate + H2O =
            1D-myo-Inositol 3-phosphate + Orthophosphate
SUBSTRATE   D-myo-Inositol 3,4-bisphosphate
            H2O
PRODUCT     1D-myo-Inositol 3-phosphate
            Orthophosphate
COMMENT     Mg2+-independent; different from EC 3.1.3.57, 3.1.3.61 and
            3.1.3.65.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       HSA: 3631(INPP4A) 8821(INPP4B)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.66
            ExPASy - ENZYME nomenclature database: 3.1.3.66
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.66
            BRENDA, the Enzyme Database: 3.1.3.66
///
ENTRY       EC 3.1.3.67
NAME        Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
REACTION    Phosphatidylinositol-3,4,5-trisphosphate + H2O =
            Phosphatidylinositol-4,5-bisphosphate + Phosphate
SUBSTRATE   Phosphatidylinositol-3,4,5-trisphosphate
            H2O
PRODUCT     Phosphatidylinositol-4,5-bisphosphate
            Phosphate
COFACTOR    Magnesium
COMMENT     Does not dephosphorylate inositol 4,5-bisphosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.67
            ExPASy - ENZYME nomenclature database: 3.1.3.67
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.67
///
ENTRY       EC 3.1.3.68
NAME        2-Deoxyglucose-6-phosphatase
            2-Deoxyglucose-6-phosphate phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric monoester hydrolases
REACTION    2-Deoxy-D-glucose 6-phosphate + H2O = 2-Deoxy-D-glucose +
            Phosphate;
            D-Fructose 1,6-bisphosphate + H2O = D-Fructose 1-phosphate +
            Phosphate
SUBSTRATE   2-Deoxy-D-glucose 6-phosphate
            H2O
            D-Fructose 1,6-bisphosphate
PRODUCT     2-Deoxy-D-glucose
            Phosphate
            D-Fructose 1-phosphate
COMMENT     Also active towards fructose 1-phosphate.
GENES       SCE: YHR043C(DOG2) YHR044C(DOG1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.3.68
            ExPASy - ENZYME nomenclature database: 3.1.3.68
            WIT (What Is There) Metabolic Reconstruction: 3.1.3.68
///
ENTRY       EC 3.1.4.1
NAME        Phosphodiesterase I
            5'-Exonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Oligonucleate 5'-nucleotidohydrolase
REACTION    Hydrolytically removes 5'-nucleotides successively from the
            3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
SUBSTRATE   3'-Hydroxy-terminated oligonucleotide
            H2O
PRODUCT     5'-Nucleotide
COMMENT     Low activity towards polynucleotides. A 3'-phosphate terminus on
            the substrate inhibits hydrolysis.
GENES       BSU: BG11174(phoD)
            MMU: 97370(Pdnp1)
            HSA: 5169(ENPP3)
MOTIF       PS: PS00524  C-x-C-x(3)-C-x(5)-C-C-x-[DN]-[FY]-x(3)-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.1
            ExPASy - ENZYME nomenclature database: 3.1.4.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.1
            BRENDA, the Enzyme Database: 3.1.4.1
///
ENTRY       EC 3.1.4.2
NAME        Glycerophosphocholine phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     sn-Glycero-3-phosphocholine glycerophosphohydrolase
REACTION    sn-Glycero-3-phosphocholine + H2O = Choline +
            sn-Glycerol 3-phosphate
SUBSTRATE   sn-Glycero-3-phosphoethanolamine
            sn-Glycero-3-phosphocholine
            H2O
PRODUCT     Choline
            sn-Glycerol 3-phosphate
            Ethanolamine
COMMENT     Also acts on sn-glycero-3-phosphoethanolamine.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.2
            ExPASy - ENZYME nomenclature database: 3.1.4.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.2
            BRENDA, the Enzyme Database: 3.1.4.2
///
ENTRY       EC 3.1.4.3
NAME        Phospholipase C
            Lipophosphodiesterase I
            Lecithinase C
            Clostridium welchii alpha-toxin
            Clostridium oedematiens beta- and gamma-toxins
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Phosphatidylcholine cholinephosphohydrolase
REACTION    a Phosphatidylcholine + H2O = 1,2-Diacylglycerol +
            Choline phosphate
SUBSTRATE   Phosphatidylcholine
            Sphingomyelin
            H2O
PRODUCT     1,2-Diacylglycerol
            Choline phosphate
COFACTOR    Zinc
COMMENT     The bacterial enzyme, which is a zinc protein, also acts on
            shingomyelin and phosphatidylinositol; that from seminal plasma
            does not act on phosphatidylinositol.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00562  Inositol phosphate metabolism
            PATH: MAP00580  Phospholipid degradation
GENES       PAE: PA0844(plcH) PA3319(plcN)
MOTIF       PS: PS00384  H-Y-x-[GT]-D-[LIVM]-[DNS]-x-P-x-H-[PA]-x-N
STRUCTURES  PDB: 1AH7  1IHJ  1CA1  1QM6  1QMD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.3
            ExPASy - ENZYME nomenclature database: 3.1.4.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.3
            BRENDA, the Enzyme Database: 3.1.4.3
            SCOP (Structural Classification of Proteins): 3.1.4.3
///
ENTRY       EC 3.1.4.4
NAME        Phospholipase D
            Lipophosphodiesterase II
            Lecithinase D
            Choline phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Phosphatidylcholine phosphatidohydrolase
REACTION    a Phosphatidylcholine + H2O = Choline + a Phosphatidate
SUBSTRATE   Phosphatidylcholine
            H2O
            Phosphatidyl ester
            Phosphatidylethanolamine
            Phosphatidylserine
            Phosphatidylinositol
PRODUCT     Choline
            Phosphatidate
            Ethanolamine
            Serine
            Inositol
COFACTOR    Zinc
COMMENT     Also acts on other phosphatidyl esters.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
GENES       SCE: YKR031C(SPO14)
            ATH: At1g52570(F6D8.21)
            DME: CG12110
            HSA: 5337(PLD1) 5338(PLD2)
MOTIF       PS: PS50004  C2-domain profile
STRUCTURES  PDB: 1F0I  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.4
            ExPASy - ENZYME nomenclature database: 3.1.4.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.4
            BRENDA, the Enzyme Database: 3.1.4.4
///
ENTRY       EC 3.1.4.5
NAME        Transferred to EC 3.1.21.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.21.1 - Deoxyribonuclease I.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.5
            ExPASy - ENZYME nomenclature database: 3.1.4.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.5
///
ENTRY       EC 3.1.4.6
NAME        Transferred to EC 3.1.22.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.22.1 - Deoxyribonuclease II.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.6
            ExPASy - ENZYME nomenclature database: 3.1.4.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.6
///
ENTRY       EC 3.1.4.7
NAME        Transferred to EC 3.1.31.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.31.1 - Micrococcal nuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.7
            ExPASy - ENZYME nomenclature database: 3.1.4.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.7
///
ENTRY       EC 3.1.4.8
NAME        Transferred to EC 3.1.27.3
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.27.3 - Ribonuclease T1.
STRUCTURES  PDB: 2SAR  1SAR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.8
            ExPASy - ENZYME nomenclature database: 3.1.4.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.8
            SCOP (Structural Classification of Proteins): 3.1.4.8
///
ENTRY       EC 3.1.4.9
NAME        Transferred to EC 3.1.30.2
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.30.2 - Serratia marcescens nuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.9
            ExPASy - ENZYME nomenclature database: 3.1.4.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.9
///
ENTRY       EC 3.1.4.10
NAME        1-Phosphatidylinositol phosphodiesterase
            Monophosphatidylinositol phosphodiesterase
            Phosphatidylinositol phospholipase C
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     1-Phosphatidyl-D-myo-inositol inositolphosphohydrolase
            (cyclic-phosphate-forming)
REACTION    1-Phosphatidyl-D-myo-inositol =
            D-myo-Inositol 1,2-cyclic phosphate + Diacylglycerol
SUBSTRATE   1-Phosphatidyl-D-myo-inositol
PRODUCT     D-myo-Inositol 1,2-cyclic phosphate
            Diacylglycerol
            D-myo-Inositol 1-phosphate
COMMENT     The animal enzyme, but not that from bacteria, hydrolyses the
            cyclic-phosphate forming inositol 1-phosphate as the final
            product.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       SAU: SA0091(plc)
            SAV: SAV0089(plc)
MOTIF       PS: PS50007  Phosphatidylinositol-specific phospholipase X-
                         box domain profile
STRUCTURES  PDB: 1PTG  2PLC  2PTD  3PTD  4PTD  5PTD  1PTD  1AOD  7PTD  6PTD  
                 1GYM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.10
            ExPASy - ENZYME nomenclature database: 3.1.4.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.10
            BRENDA, the Enzyme Database: 3.1.4.10
            SCOP (Structural Classification of Proteins): 3.1.4.10
///
ENTRY       EC 3.1.4.11
NAME        1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase
            Triphosphoinositide phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     1-Phosphatidyl-D-myo-inositol-4,5-bisphosphate
            inositoltrisphosphohydrolase
REACTION    1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O =
            D-myo-Inositol 1,4,5-trisphosphate + Diacylglycerol
SUBSTRATE   1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
            H2O
            Phosphatidylinositol phosphate
PRODUCT     D-myo-Inositol 1,4,5-trisphosphate
            Diacylglycerol
COMMENT     Also hydrolyses phosphatidylinositol phosphates.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
GENES       SCE: YPL268W(PLC1)
            SPO: PLC1(plc1)
            CEL: K10F12.3 R05G6.8 T01E8.3
            DME: CG3620(norpA) CG4200 CG4574(Plc21C)
            MMU: 97615(Plcg1)
            HSA: 23236(KIAA0581) 5330(PLCB2) 5331(PLCB3) 5332(PLCB4)
                 5333(PLCD1) 5335(PLCG1) 5336(PLCG2)
DISEASE     MIM: 172420  Phospholipase C, gamma 1 (formerly subtype 148)
            MIM: 600220  Phospholipase C, gamma 2
                         (phosphatidylyinositol-specific)
            MIM: 600230  Phospholipase C, beta 3
                         (phosphatidylinositol-specific)
            MIM: 602142  Phospholipase C, delta-1
            MIM: 604114  Phospholipase C, beta-2
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS50001  Src homology 2 (SH2) domain profile
            PS: PS50002  Src homology 3 (SH3) domain profile
            PS: PS50003  PH domain profile
            PS: PS50004  C2-domain profile
            PS: PS50007  Phosphatidylinositol-specific phospholipase X-
                         box domain profile
            PS: PS50008  Phosphatidylinositol-specific phospholipase Y-
                         box domain profile
STRUCTURES  PDB: 1MAI  1QAS  1QAT  2HSP  1HSQ  2PLD  2PLE  1DJW  1DJI  1DJH  
                 1DJG  1DJY  1DJZ  1DJX  2ISD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.11
            ExPASy - ENZYME nomenclature database: 3.1.4.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.11
            BRENDA, the Enzyme Database: 3.1.4.11
            SCOP (Structural Classification of Proteins): 3.1.4.11
///
ENTRY       EC 3.1.4.12
NAME        Sphingomyelin phosphodiesterase
            Neutral sphingomyelinase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Sphingomyelin cholinephosphohydrolase
REACTION    Sphingomyelin + H2O =  N-Acylsphingosine + Choline phosphate
SUBSTRATE   Sphingomyelin
            H2O
            Phosphatidylcholine
PRODUCT     N-Acylsphingosine
            Choline phosphate
COMMENT     Has very little activity on phosphatidylcholine.
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
GENES       CEL: B0252.2
            HSA: 6609(SMPD1)
DISEASE     MIM: 257200  Sphingomyelin phosphodiesterase-1, acid lysosomal
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.12
            ExPASy - ENZYME nomenclature database: 3.1.4.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.12
            BRENDA, the Enzyme Database: 3.1.4.12
///
ENTRY       EC 3.1.4.13
NAME        Serine-ethanolaminephosphate phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Serine-phosphoethanolamine ethanolaminephosphohydrolase
REACTION    Serine phosphoethanolamine + H2O = Serine + Ethanolamine phosphate
SUBSTRATE   Serine phosphoethanolamine
            H2O
PRODUCT     Serine
            Ethanolamine phosphate
COMMENT     Acts only on those phosphodiesters that have ethanolamine as a
            component part of the molecule.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.13
            ExPASy - ENZYME nomenclature database: 3.1.4.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.13
            BRENDA, the Enzyme Database: 3.1.4.13
///
ENTRY       EC 3.1.4.14
NAME        [Acyl-carrier-protein] phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     [Acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
REACTION    [Acyl-carrier protein] + H2O = Phosphopantetheine + Apoprotein
SUBSTRATE   [Acyl-carrier protein]
            H2O
PRODUCT     Phosphopantetheine
            Apoprotein
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b1412(acpD)
            ECE: Z2315(acpD)
            ECS: ECs2014
            YPE: YPO2323(acpD)
            HIN: HI1366(acpd)
            PAE: PA0785 PA3223(acpD)
            MLO: mlr2421
            BSU: BG13523(yocJ) BG14058(yvaB)
            BHA: BH3860 BH4043
            SAU: SA0204
            SAV: SAV0206
            LLA: L115551(acpD) L186107(ydiD)
            CAC: CAC3421
            MPN: P01_orf197
            MPU: MYPU_3120(acpD)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.14
            ExPASy - ENZYME nomenclature database: 3.1.4.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.14
            BRENDA, the Enzyme Database: 3.1.4.14
///
ENTRY       EC 3.1.4.15
NAME        Adenylyl-[glutamate--ammonia ligase] hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]
            $ adenylylhydrolase
REACTION    Adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O =
            Adenylate + [L-Glutamate:ammonia ligase (ADP-forming)]
SUBSTRATE   Adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]
            H2O
PRODUCT     Adenylate
            [L-Glutamate:ammonia ligase (ADP-forming)]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.15
            ExPASy - ENZYME nomenclature database: 3.1.4.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.15
            BRENDA, the Enzyme Database: 3.1.4.15
///
ENTRY       EC 3.1.4.16
NAME        2',3'-Cyclic-nucleotide 2'-phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase
REACTION    Nucleoside 2',3'-cyclic phosphate + H2O = Nucleoside 3'-phosphate
SUBSTRATE   Nucleoside 2',3'-cyclic phosphate
            3'-Nucleoside monophosphate
            Bis-4-nitrophenyl phosphate
            H2O
PRODUCT     Nucleoside 3'-phosphate
COMMENT     Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl
            phosphate, but not 3'-deoxynucleotides. Similar reactions are
            carried out by EC 3.1.27.3 and 3.1.27.5.
            (EC 3.1.27.3 Ribonuclease T1)
            (EC 3.1.27.5 Pancreatic ribonuclease)
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b4213(cpdB)
            ECE: Z5824(cpdB)
            ECS: ECs5191
            YPE: YPO3530(cpdB)
            HIN: HI0583(cpdB)
            PMU: PM2014(cpdB)
            VCH: VC2416 VC2562
            HPY: HP0104(cpdB)
            HPJ: jhp0096
            MLO: mlr0366
            SME: SMc04449(cpdB)
            BSU: BG12930(yfkN)
            CAC: CAC0353
            DRA: DR1736
MOTIF       PS: PS00785  [LIVM]-x-[LIVM](2)-[HEA]-[TI]-x-D-x-H-[GSA]-x-[LIVMF]
            PS: PS00786  [FYP]-x(4)-[LIVM]-G-N-H-E-F-[DN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.16
            ExPASy - ENZYME nomenclature database: 3.1.4.16
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.16
            BRENDA, the Enzyme Database: 3.1.4.16
///
ENTRY       EC 3.1.4.17
NAME        3',5'-Cyclic-nucleotide phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     3',5'-Cyclic-nucleotide 5'-nucleotidohydrolase
REACTION    Nucleoside 3',5'-cyclic phosphate + H2O = Nucleoside 5'-phosphate
SUBSTRATE   Nucleoside 3',5'-cyclic phosphate
            3',5'-Cyclic AMP
            3',5'-Cyclic dAMP
            3',5'-Cyclic IMP
            3',5'-Cyclic GMP
            3',5'-Cyclic CMP
            H2O
PRODUCT     Nucleoside 5'-phosphate
            AMP
            dAMP
            IMP
            GMP
            CMP
COMMENT     Act on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP,
            3',5'-cyclic GMP and 3',5'-cyclic CMP.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       MLO: mll8078 mll9676
            SCE: YGL248W(PDE1) YOR360C(PDE2)
            SPO: CGS2(cgs2)
            CEL: C32E12.2 R08D7.6 R153.1 T04D3.3
            DME: CG10797(dnc) CG14940
            MMU: 1202402(Pde7a) 97524(Pdea) 97525(Pdeb) 97526(Pdeg)
            HSA: 10846(PDE10A) 27115(PDE7B) 5136(PDE1A) 5137(PDE1C)
                 5138(PDE2A) 5139(PDE3A) 5140(PDE3B) 5141(PDE4A) 5142(PDE4B)
                 5143(PDE4C) 5144(PDE4D) 5145(PDE6A) 5146(PDE6C) 5147(PDE6D)
                 5148(PDE6G) 5149(PDE6H) 5152(PDE9A) 5153(PDE1B) 5158(PDE6B)
                 8654(PDE5A)
DISEASE     MIM: 171890  Phosphodiesterase-1A
            MIM: 180072  Phosphodiesterase-6B, cGMP-specific, rod, beta
            MIM: 180073  Phosphodiesterase-6G, cGMP-specific, rod, gamma
            MIM: 600126  Phosphodiesterase-4A, cAMP-specific (dunce,
                         Drosophila, homolog
            MIM: 600127  Phosphodiesterase-4B, cAMP-specific (dunce-like
                         phosphodiesterase E4)
            MIM: 600128  Phosphodiesterase-4C, cAMP-specific (dunce,
                         Drosophila, homolog
            MIM: 600129  Phosphodiesterase-4D, cAMP-specific (dunce,
                         Drosophila, homolog of,
            MIM: 600827  Phosphodiesterase-6C, cGMP-specific, cone, alpha prime
MOTIF       PS: PS00126  H-D-[LIVMFY]-x-H-x-[AG]-x(2)-[NQ]-x-[LIVMFY]
            PS: PS00607  H-x-H-L-D-H-[LIVM]-x-[GS]-[LIVMA]-[LIVM](2)-x-S-[AP]
STRUCTURES  PDB: 1F0J  1LOI  1JP2  1JP1  1FQJ  1FL4  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.17
            ExPASy - ENZYME nomenclature database: 3.1.4.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.17
            BRENDA, the Enzyme Database: 3.1.4.17
            SCOP (Structural Classification of Proteins): 3.1.4.17
///
ENTRY       EC 3.1.4.18
NAME        Transferred to EC 3.1.16.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.16.1 - Spleen exonuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.18
            ExPASy - ENZYME nomenclature database: 3.1.4.18
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.18
///
ENTRY       EC 3.1.4.19
NAME        Transferred to EC 3.1.13.3
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.13.3 - Oligonucleotidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.19
            ExPASy - ENZYME nomenclature database: 3.1.4.19
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.19
///
ENTRY       EC 3.1.4.20
NAME        Transferred to EC 3.1.13.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.13.1 - Exoribonuclease II.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.20
            ExPASy - ENZYME nomenclature database: 3.1.4.20
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.20
///
ENTRY       EC 3.1.4.21
NAME        Transferred to EC 3.1.30.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.30.1 - Aspergillus nuclease S1.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.21
            ExPASy - ENZYME nomenclature database: 3.1.4.21
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.21
///
ENTRY       EC 3.1.4.22
NAME        Transferred to EC 3.1.27.5
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.27.5 - Pancreatic ribonuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.22
            ExPASy - ENZYME nomenclature database: 3.1.4.22
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.22
///
ENTRY       EC 3.1.4.23
NAME        Transferred to EC 3.1.27.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.27.1 - Ribonuclease T2.
STRUCTURES  PDB: 1RMS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.23
            ExPASy - ENZYME nomenclature database: 3.1.4.23
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.23
            SCOP (Structural Classification of Proteins): 3.1.4.23
///
ENTRY       EC 3.1.4.24
NAME        Deleted entry
            Endoribonuclease III
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.24
            ExPASy - ENZYME nomenclature database: 3.1.4.24
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.24
///
ENTRY       EC 3.1.4.25
NAME        Transferred to EC 3.1.11.1
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.11.1 - Exodeoxyribonuclease I.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.25
            ExPASy - ENZYME nomenclature database: 3.1.4.25
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.25
///
ENTRY       EC 3.1.4.26
NAME        Deleted entry
            Exodeoxyribonuclease II
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.26
            ExPASy - ENZYME nomenclature database: 3.1.4.26
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.26
///
ENTRY       EC 3.1.4.27
NAME        Transferred to EC 3.1.11.2
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.11.2 - Exodeoxyribonuclease III.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.27
            ExPASy - ENZYME nomenclature database: 3.1.4.27
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.27
///
ENTRY       EC 3.1.4.28
NAME        Transferred to EC 3.1.11.3
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.11.3 - Exodeoxyribonuclease
            (lambda-induced).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.28
            ExPASy - ENZYME nomenclature database: 3.1.4.28
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.28
///
ENTRY       EC 3.1.4.29
NAME        Deleted entry
            Oligodeoxyribonucleate exonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.29
            ExPASy - ENZYME nomenclature database: 3.1.4.29
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.29
///
ENTRY       EC 3.1.4.30
NAME        Transferred to EC 3.1.21.2
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.21.2 - Deoxyribonuclease IV
            (Phage T4-induced).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.30
            ExPASy - ENZYME nomenclature database: 3.1.4.30
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.30
///
ENTRY       EC 3.1.4.31
NAME        Transferred to EC 3.1.11.4
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Transferred entry. Now EC 3.1.11.4 - Exodeoxyribonuclease
            (Phage SP3-induced).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.31
            ExPASy - ENZYME nomenclature database: 3.1.4.31
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.31
///
ENTRY       EC 3.1.4.32
NAME        Deleted entry
            Endodeoxyribonuclease (ATP- and S-adenosylmethionine-dependent)
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry. See subclass 3.1.24.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.32
            ExPASy - ENZYME nomenclature database: 3.1.4.32
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.32
///
ENTRY       EC 3.1.4.33
NAME        Deleted entry
            Endodeoxyribonuclease (ATP-hydrolysing)
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry. See subclass 3.1.24.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.33
            ExPASy - ENZYME nomenclature database: 3.1.4.33
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.33
///
ENTRY       EC 3.1.4.34
NAME        Deleted entry
            Hybrid nuclease
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
COMMENT     Deleted entry. See subclasses 3.1.15, 3.1.16, 3.1.30 and 3.1.31.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.34
            ExPASy - ENZYME nomenclature database: 3.1.4.34
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.34
///
ENTRY       EC 3.1.4.35
NAME        3',5'-Cyclic-GMP phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     3',5'-Cyclic-GMP 5'-nucleotidohydrolase
REACTION    Guanosine 3',5'-cyclic phosphate + H2O = Guanosine 5'-phosphate
SUBSTRATE   Guanosine 3',5'-cyclic phosphate
            H2O
PRODUCT     Guanosine 5'-phosphate
DISEASE     MIM: 180071  Phosphodiesterase-6A, cGMP-specific, rod, alpha
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.35
            ExPASy - ENZYME nomenclature database: 3.1.4.35
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.35
            BRENDA, the Enzyme Database: 3.1.4.35
///
ENTRY       EC 3.1.4.36
NAME        1,2-Cyclic-inositol-phosphate phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     1D-myo-Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase
REACTION    1D-myo-Inositol 1,2-cyclic phosphate + H2O =
            1D-myo-Inositol 1-phosphate
SUBSTRATE   1D-myo-Inositol 1,2-cyclic phosphate
            H2O
PRODUCT     1D-myo-Inositol 1-phosphate
GENES       HSA: 306(ANXA3)
DISEASE     MIM: 106490  Annexin A3 (lipocortin III)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.36
            ExPASy - ENZYME nomenclature database: 3.1.4.36
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.36
            BRENDA, the Enzyme Database: 3.1.4.36
///
ENTRY       EC 3.1.4.37
NAME        2',3'-Cyclic-nucleotide 3'-phosphodiesterase
            Cyclic-CMP phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
REACTION    Nucleoside 2',3'-cyclic phosphate + H2O = Nucleoside 2'-phosphate
SUBSTRATE   Nucleoside 2',3'-cyclic phosphate
            2',3'-Cyclic AMP
            2',3'-Cyclic UMP
            2',3'-Cyclic CMP
            H2O
PRODUCT     Nucleoside 2'-phosphate
            Adenosine 2'-phosphate
            Uridine 2'-phosphate
            Cytidine 2'-phosphate
COMMENT     The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on
            the UMP or CMP derivatives. An enzyme from liver acts on
            2',3'-cyclic CMP more rapidly than on the purine derivatives;
            it also hydrolyses the corresponding 3',5'-cyclic phosphates,
            more slowly. This latter enzyme has been called cyclic-CMP
            phosphodiesterase.
GENES       MMU: 88437(Cnp1)
            HSA: 1267(CNP)
DISEASE     MIM: 123830  2', 3' cyclic nucleotide 3' phosphohydrolase
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.37
            ExPASy - ENZYME nomenclature database: 3.1.4.37
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.37
            BRENDA, the Enzyme Database: 3.1.4.37
///
ENTRY       EC 3.1.4.38
NAME        Glycerophosphocholine cholinephosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     sn-Glycero-3-phosphocholine cholinephosphohydrolase
REACTION    sn-Glycero-3-phosphocholine + H2O = Glycerol + Choline phosphate
SUBSTRATE   sn-Glycero-3-phosphocholine
            H2O
PRODUCT     Glycerol
            Choline phosphate
COMMENT     No activity on sn-3-glycerophosphoethanolamine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.38
            ExPASy - ENZYME nomenclature database: 3.1.4.38
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.38
            BRENDA, the Enzyme Database: 3.1.4.38
///
ENTRY       EC 3.1.4.39
NAME        Alkylglycerophosphoethanolamine phosphodiesterase
            Lysophospholipase D
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     1-Alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase
REACTION    1-Alkyl-sn-glycero-3-phosphoethanolamine + H2O =
            1-Alkyl-sn-glycerol 3-phosphate + Ethanolamine
SUBSTRATE   1-Alkyl-sn-glycero-3-phosphoethanolamine
            H2O
            1-Acyl-sn-glycero-3-phosphoethanolamine
PRODUCT     1-Alkyl-sn-glycerol 3-phosphate
            Ethanolamine
            1-Acyl-sn-glycerol 3-phosphate
COMMENT     Also acts on acyl and choline analogues.
GENES       AFU: AF1753
STRUCTURES  PDB: 1FJ2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.39
            ExPASy - ENZYME nomenclature database: 3.1.4.39
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.39
            BRENDA, the Enzyme Database: 3.1.4.39
            SCOP (Structural Classification of Proteins): 3.1.4.39
///
ENTRY       EC 3.1.4.40
NAME        CMP-N-acylneuraminate phosphodiesterase
            CMP-sialate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     CMP-N-acylneuraminate N-acylneuraminohydrolase
REACTION    CMP-N-acylneuraminate + H2O = CMP + N-Acylneuraminate
SUBSTRATE   CMP-N-acylneuraminate
            H2O
PRODUCT     CMP
            N-Acylneuraminate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.40
            ExPASy - ENZYME nomenclature database: 3.1.4.40
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.40
            BRENDA, the Enzyme Database: 3.1.4.40
///
ENTRY       EC 3.1.4.41
NAME        Sphingomyelin phosphodiesterase D
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Sphingomyelin ceramide-phosphohydrolase
REACTION    Sphingomyelin + H2O = Ceramide phosphate + Choline
SUBSTRATE   Sphingomyelin
            H2O
            2-Lysophosphatidylcholine
PRODUCT     Ceramide phosphate
            Choline
            2-Lysophosphatidate
COMMENT     Does not act on phosphatidylcholine, but hydrolyses
            2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.41
            ExPASy - ENZYME nomenclature database: 3.1.4.41
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.41
            BRENDA, the Enzyme Database: 3.1.4.41
///
ENTRY       EC 3.1.4.42
NAME        Glycerol-1,2-cyclic-phosphate 2-phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     rac-Glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase
REACTION    Glycerol 1,2-cyclic phosphate + H2O = Glycerol 1-phosphate
SUBSTRATE   Glycerol 1,2-cyclic phosphate
            H2O
PRODUCT     Glycerol 1-phosphate
COMMENT     Acts on both stereoisomers of the substrate, and also, more
            slowly, on 3',5'-cyclic AMP and on 2',3'-cyclic AMP.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.42
            ExPASy - ENZYME nomenclature database: 3.1.4.42
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.42
            BRENDA, the Enzyme Database: 3.1.4.42
///
ENTRY       EC 3.1.4.43
NAME        Glycerophosphoinositol inositolphosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     sn-Glycero-3-phospho-1-inositol inositolphosphohydrolase
REACTION    sn-Glycero-3-phospho-1-inositol + H2O = Glycerol +
            Inositol 1-phosphate
SUBSTRATE   sn-Glycero-3-phospho-1-inositol
            H2O
PRODUCT     Glycerol
            Inositol 1-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.43
            ExPASy - ENZYME nomenclature database: 3.1.4.43
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.43
            BRENDA, the Enzyme Database: 3.1.4.43
///
ENTRY       EC 3.1.4.44
NAME        Glycerophosphoinositol glycerophosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     sn-Glycero-3-phospho-1-inositol glycerophosphohydrolase
REACTION    sn-Glycero-3-phospho-1-inositol + H2O = Inositol +
            sn-Glycerol 3-phosphate
SUBSTRATE   sn-Glycero-3-phospho-1-inositol
            H2O
PRODUCT     Inositol
            sn-Glycerol 3-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.44
            ExPASy - ENZYME nomenclature database: 3.1.4.44
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.44
            BRENDA, the Enzyme Database: 3.1.4.44
///
ENTRY       EC 3.1.4.45
NAME        N-Acetylglucosamine-1-phosphodiester
            $ alpha-N-acetylglucosaminidase
            alpha-N-Acetylglucosaminyl phosphodiesterase
            Lysosomal alpha-N-acetylglucosaminidase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose
            $ N-acetyl-D-glucosaminylphosphohydrolase
REACTION    Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O =
            N-Acetyl-D-glucosamine + Glycoprotein phospho-D-mannose
SUBSTRATE   Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose
            H2O
PRODUCT     N-Acetyl-D-glucosamine
            Glycoprotein phospho-D-mannose
COMMENT     Acts on a variety of compounds in which N-acetyl-D-glucosamine is
            alpha-linked to a phosphate group, including the biosynthetic
            intermediates of the high mannose oligosaccharide components of
            some lysosomal enzymes and the products of EC 2.7.8.17.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.45
            ExPASy - ENZYME nomenclature database: 3.1.4.45
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.45
            BRENDA, the Enzyme Database: 3.1.4.45
///
ENTRY       EC 3.1.4.46
NAME        Glycerophosphodiester phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Glycerophosphodiester glycerophosphohydrolase
REACTION    a Glycerophosphodiester + H2O = an Alcohol +
            sn-Glycerol 3-phosphate
SUBSTRATE   Glycerophosphodiester
            H2O
            Glycerophosphocholine
            Glycerophosphoethanolamine
            Glycerophosphoglycerol
            Bis(glycerophospho)-glycerol
PRODUCT     Alcohol
            sn-Glycerol 3-phosphate
            Choline
            Ethanolamine
            Glycerol
            Glycerophosphoglycerol
COMMENT     Broad specificity for glycerophosphodiesters;
            glycerophosphocholine, glycerophosphoethanolamine,
            glycerophosphoglycerol, and bis(glycerophospho)-glycerol are
            hydrolysed.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
GENES       ECO: b2239(glpQ) b3449(ugpQ)
            ECE: Z3497(glpQ) Z4817(ugpQ)
            ECS: ECs3124 ECs4295
            YPE: YPO3792(ugpQ) YPO3827(glpQ)
            HIN: HI0689(glpQ)
            PMU: PM1444(glpQ)
            VCH: VC1554 VCA0136
            PAE: PA0347(glpQ) PA2352 PA2990
            CCR: CC3272
            BSU: BG10646(glpQ) BG11719(yqiK) BG13029(yhdW)
            BHA: BH1080 BH1776 BH3700(glpQ)
            SAU: SA0036 SA0220 SA0820(glpQ)
            SAV: SAV0035 SAV0946(glpQ)
            SPY: SPy0839
            SPN: SP0994
            SPR: spr0897
            CAC: CAC0430
            MGE: MG293
            MPN: A05_orf241a(glpQ) H03_orf237(glpQ)
            MPU: MYPU_2630(glpQ)
            MTU: Rv0317c(glpQ2) Rv3842c(glpQ1)
            MTC: MT0332 MT3950
            MLE: ML0074(glpQ)
            TPA: TP0257
            DRA: DR0542 DR2084 DRB0111
            HAL: VNG1846C
            TAC: Ta0634
            TVO: TVG0876539
            PAB: PAB0180
            APE: APE0262
            SCE: YPL206C
            SPO: SPAC4D7.02C(spac4d7.02c)
            CEL: F55C5.2 T12B3.3
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.46
            ExPASy - ENZYME nomenclature database: 3.1.4.46
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.46
            BRENDA, the Enzyme Database: 3.1.4.46
///
ENTRY       EC 3.1.4.47
NAME        Variant-surface-glycoprotein phospholipase C
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Variant-surface-glycoprotein-1,2-didecanoyl-sn-phosphatidyl-
            $inositol inositolphosphohydrolase
REACTION    Variant-surface-glycoprotein 1,2-didecanoyl-sn-phosphatidyl-
            $inositol + H2O = 1,2-Didecanoylglycerol + Soluble variant-
            $surface-glycoprotein
SUBSTRATE   Variant-surface-glycoprotein 1,2-didecanoyl-sn-phosphatidyl-
            $inositol
            H2O
            1,2-Didecanoyl-sn-phosphatidylinositol
PRODUCT     1,2-Didecanoylglycerol
            Soluble variant-surface-glycoprotein
COMMENT     By hydrolysis of the attached glycolipid, releases soluble
            variant-surface-glycoprotein containing phosphoinositol from the
            cell wall of Trypanosoma brucei after cell lysis. Highly specific;
            acts very slowly on free 1,2-didecanoyl-sn-phosphatidylinositol.
            Not identical with EC 3.1.4.50.
MOTIF       PS: PS50007  Phosphatidylinositol-specific phospholipase X-
                         box domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.47
            ExPASy - ENZYME nomenclature database: 3.1.4.47
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.47
            BRENDA, the Enzyme Database: 3.1.4.47
///
ENTRY       EC 3.1.4.48
NAME        Dolichyl-phosphate-glucose phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase
REACTION    Dolichyl beta-D-glucosyl phosphate + H2O = Dolichyl phosphate +
            D-Glucose
SUBSTRATE   Dolichyl beta-D-glucosyl phosphate
            H2O
PRODUCT     Dolichyl phosphate
            D-Glucose
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.48
            ExPASy - ENZYME nomenclature database: 3.1.4.48
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.48
            BRENDA, the Enzyme Database: 3.1.4.48
///
ENTRY       EC 3.1.4.49
NAME        Dolichyl-phosphate-mannose phosphodiesterase
            Mannosylphosphodolichol phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase
REACTION    Dolichyl beta-D-mannosyl phosphate + H2O = Dolichyl phosphate +
            D-Mannose
SUBSTRATE   Dolichyl beta-D-mannosyl phosphate
            H2O
PRODUCT     Dolichyl phosphate
            D-Mannose
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.49
            ExPASy - ENZYME nomenclature database: 3.1.4.49
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.49
            BRENDA, the Enzyme Database: 3.1.4.49
///
ENTRY       EC 3.1.4.50
NAME        Glycoprotein phospholipase D
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Glycoprotein-phosphatidylinositol phosphatidohydrolase
REACTION    Glycoprotein phosphatidylinositol + H2O = Phosphatidate +
            Glycoprotein inositol
SUBSTRATE   Glycoprotein phosphatidylinositol
            H2O
PRODUCT     Phosphatidate
            Glycoprotein inositol
COMMENT     By hydrolysis, degrades the glycosylphosphatidylinositol membrane
            anchor of cell-surface proteins in animal tissues, thus releasing
            these protein from the membrane. Not identical with EC 3.1.4.47.
GENES       HSA: 2822(GPLD1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.50
            ExPASy - ENZYME nomenclature database: 3.1.4.50
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.50
            BRENDA, the Enzyme Database: 3.1.4.50
///
ENTRY       EC 3.1.4.51
NAME        Glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase
            alpha-Glucose-1-phosphate phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     6-(D-Glucose-1-phospho)-D-mannosylglycoprotein
            $ glucose-1-phosphohydrolase
REACTION    6-(D-Glucose-1-phospho)-D-mannosylglycoprotein + H2O =
            alpha-D-Glucose 1-phosphate + D-Mannosylglycoprotein
SUBSTRATE   6-(D-Glucose-1-phospho)-D-mannosylglycoprotein
            H2O
PRODUCT     alpha-D-Glucose 1-phosphate
            D-Mannosylglycoprotein
COMMENT     The enzyme is specific for the product of EC 2.7.8.19.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.4.51
            ExPASy - ENZYME nomenclature database: 3.1.4.51
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.51
            BRENDA, the Enzyme Database: 3.1.4.51
///
ENTRY       EC 3.1.5.1
NAME        dGTPase
            Deoxy-GTPase
CLASS       Hydrolases
            Acting on ester bonds
            Triphosphoric monoester hydrolases
SYSNAME     dGTP triphosphohydrolase
REACTION    dGTP + H2O = Deoxyguanosine + Triphosphate
SUBSTRATE   dGTP
            H2O
            GTP
PRODUCT     Deoxyguanosine
            Triphosphate
            Guanosine
COMMENT     Also acts on GTP.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0160(dgt)
            ECE: Z0171(dgt)
            ECS: ECs0164
            YPE: YPO3383(dgt)
            PMU: PM0878
            VCH: VC1979
            PAE: PA1124(dgt)
            RPR: RP064(dgtP)
            RCO: RC0094(dgtP)
            MLO: mll1093
            CCR: CC2008
            MTU: Rv2344c(dgt)
            MTC: MT2409
            MLE: ML0831(dgt)
            SYN: sll0398(dgt)
            DRA: DR1808
STRUCTURES  PDB: 1HA3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.5.1
            ExPASy - ENZYME nomenclature database: 3.1.5.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.5.1
            BRENDA, the Enzyme Database: 3.1.5.1
///
ENTRY       EC 3.1.6.1
NAME        Arylsulfatase
            Sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Aryl-sulfate sulfohydrolase
REACTION    a Phenol sulfate + H2O = a Phenol + Sulfate
SUBSTRATE   Phenol sulfate
            H2O
PRODUCT     Phenol
            Sulfate
COMMENT     A group of enzymes with rather similar specificities.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
GENES       ECO: b3801(aslA)
            ECE: Z5314(aslA)
            ECS: ECs4731
            PAE: PA0183(atsA)
            SME: SMb20915(aslA1)
            HSA: 414(ARSD) 415(ARSE)
DISEASE     MIM: 300002  Arylsulfatase D
            MIM: 300180  Arylsulfatase E
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.1
            ExPASy - ENZYME nomenclature database: 3.1.6.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.1
            BRENDA, the Enzyme Database: 3.1.6.1
///
ENTRY       EC 3.1.6.2
NAME        Steryl-sulfatase
            Arylsulfatase C
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Steryl-sulfate sulfohydrolase
REACTION    3beta-Hydroxyandrost-5-en-17-one 3-sulfate + H2O =
            3beta-Hydroxyandrost-5-en-17-one + Sulfate
SUBSTRATE   3beta-Hydroxyandrost-5-en-17-one 3-sulfate
            H2O
            Steryl sulfate
PRODUCT     3beta-Hydroxyandrost-5-en-17-one
            Sulfate
COMMENT     Also acts on some related steryl sulfates.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
GENES       MMU: 98438(Sts)
            HSA: 412(STS)
DISEASE     MIM: 308100  Steroid sulfatase, microsomal (arylsulfatase C,
                         isozyme S)
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.2
            ExPASy - ENZYME nomenclature database: 3.1.6.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.2
            BRENDA, the Enzyme Database: 3.1.6.2
///
ENTRY       EC 3.1.6.3
NAME        Glycosulfatase
            Glucosulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Sugar-sulfate sulfohydrolase
REACTION    D-Glucose 6-sulfate + H2O = D-Glucose + Sulfate
SUBSTRATE   D-Glucose 6-sulfate
            H2O
PRODUCT     D-Glucose
            Sulfate
COMMENT     Also acts on other sulfates of monosaccharides and disaccharides
            and on adenosine 5'-sulfate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.3
            ExPASy - ENZYME nomenclature database: 3.1.6.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.3
            BRENDA, the Enzyme Database: 3.1.6.3
///
ENTRY       EC 3.1.6.4
NAME        N-Acetylgalactosamine-6-sulfatase
            Chondroitinsulfatase
            Chondroitininase
            Galactose-6-sulfate sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
REACTION    Hydrolysis of the 6-sulfate groups of the
            N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate
            and of the D-galactose 6-sulfate units of keratan sulfate
SUBSTRATE   Chondroitin sulfate
            Keratan sulfate
            H2O
            N-Acetyl-D-galactosamine 6-sulfate
            D-Galactose 6-sulfate
PRODUCT     Sulfate
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
GENES       HSA: 2588(GALNS)
DISEASE     MIM: 253000  Galactosamine (N-acetyl)-6-sulfate sulfatase
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.4
            ExPASy - ENZYME nomenclature database: 3.1.6.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.4
            BRENDA, the Enzyme Database: 3.1.6.4
///
ENTRY       EC 3.1.6.5
NAME        Deleted entry
            Sinigrin sulfohydrolase
            Myrosulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.5
            ExPASy - ENZYME nomenclature database: 3.1.6.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.5
///
ENTRY       EC 3.1.6.6
NAME        Choline-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Choline-sulfate sulfohydrolase
REACTION    Choline sulfate + H2O = Choline + Sulfate
SUBSTRATE   Choline sulfate
            H2O
PRODUCT     Choline
            Sulfate
GENES       PAE: PA0031(betC)
            MLO: mll7612
            SME: SMc00127(betC)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.6
            ExPASy - ENZYME nomenclature database: 3.1.6.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.6
            BRENDA, the Enzyme Database: 3.1.6.6
///
ENTRY       EC 3.1.6.7
NAME        Cellulose-polysulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Cellulose-sulfate sulfohydrolase
REACTION    Hydrolysis of the 2- and 2-sulfate groups of the polysulfates of
            cellulose and charonin.
SUBSTRATE   Polysulfate of cellulose
            Polysulfate of charonin
            H2O
PRODUCT     Polysulfate of cellulose
            Polysulfate of charonin
            Sulfate
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.7
            ExPASy - ENZYME nomenclature database: 3.1.6.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.7
            BRENDA, the Enzyme Database: 3.1.6.7
///
ENTRY       EC 3.1.6.8
NAME        Cerebroside-sulfatase
            Arylsulfatase A
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Cerebroside-3-sulfate 3-sulfohydrolase
REACTION    a Cerebroside 3-sulfate + H2O = a Cerebroside + Sulfate
SUBSTRATE   Cerebroside 3-sulfate
            H2O
            Ascorbate 2-sulfate
PRODUCT     Cerebroside
            Sulfate
            Ascorbate
COMMENT     Hydrolyses galactose-3-sulfate residues in a number of lipids.
            Also hydrolyses ascorbate 2-sulfate and many phenol sulfates.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       SME: SMa1683
            MMU: 88077(As2)
            HSA: 410(ARSA)
DISEASE     MIM: 250100  Arylsulfatase A
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
STRUCTURES  PDB: 1AUK  1E1Z  1E2S  1E33  1E3C  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.8
            ExPASy - ENZYME nomenclature database: 3.1.6.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.8
            BRENDA, the Enzyme Database: 3.1.6.8
            SCOP (Structural Classification of Proteins): 3.1.6.8
///
ENTRY       EC 3.1.6.9
NAME        Chondro-4-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-
            $4-sulfate 4-sulfohydrolase
REACTION    4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            $ 4-sulfate + H2O =
            4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine +
            Sulfate
SUBSTRATE   4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            $ 4-sulfate
            H2O
PRODUCT     4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            Sulfate
COMMENT     Also acts on the saturated analogue but not on higher
            oligosaccharides, nor any 6-sulfates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.9
            ExPASy - ENZYME nomenclature database: 3.1.6.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.9
            BRENDA, the Enzyme Database: 3.1.6.9
///
ENTRY       EC 3.1.6.10
NAME        Chondro-6-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-
            $6-sulfate 6-sulfohydrolase
REACTION    4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            $ 6-sulfate + H2O =
            4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine +
            Sulfate
SUBSTRATE   4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            $ 6-sulfate
            H2O
PRODUCT     4-Deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine
            Sulfate
COMMENT     Also acts on the saturated analogue and N-acetyl-D-galactosamine
            4,6-disulfate, but not higher oligosaccharides, nor any 4-sulfate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.10
            ExPASy - ENZYME nomenclature database: 3.1.6.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.10
            BRENDA, the Enzyme Database: 3.1.6.10
///
ENTRY       EC 3.1.6.11
NAME        Disulfoglucosamine-6-sulfatase
            N-Sulfoglucosamine-6-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N,6-O-Disulfo-D-glucosamine 6-sulfohydrolase
REACTION    N,6-O-Disulfo-D-glucosamine + H2O = N-Sulfo-D-glucosamine +
            Sulfate
SUBSTRATE   N,6-O-Disulfo-D-glucosamine
            H2O
PRODUCT     N-Sulfo-D-glucosamine
            Sulfate
COMMENT     May be identical with EC 3.1.6.14.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.11
            ExPASy - ENZYME nomenclature database: 3.1.6.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.11
            BRENDA, the Enzyme Database: 3.1.6.11
///
ENTRY       EC 3.1.6.12
NAME        N-Acetylgalactosamine-4-sulfatase
            Chondroitinsulfatase
            Chondroitinase
            Arylsulfatase B
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
REACTION    Hydrolysis of the 4-sulfate groups of the
            N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate
            and dermatan sulfate
SUBSTRATE   Chondroitin sulfate
            Dermatan sulfate
            H2O
            N-Acetyl-D-glucosamine 4-sulfate
PRODUCT     Chondroitin
            Dermatan
            Sulfate
            N-Acetyl-D-glucosamine
COMMENT     Acts also on N-acetylglucosamine 4-sulfate.
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
GENES       HSA: 411(ARSB)
DISEASE     MIM: 253200  Arylsulfatase B
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
STRUCTURES  PDB: 1FSU  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.12
            ExPASy - ENZYME nomenclature database: 3.1.6.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.12
            BRENDA, the Enzyme Database: 3.1.6.12
            SCOP (Structural Classification of Proteins): 3.1.6.12
///
ENTRY       EC 3.1.6.13
NAME        Iduronate-2-sulfatase
            Chondroitinsulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     L-iduronate-2-sulfate 2-sulfohydrolase
REACTION    Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate
            units of dermatan sulfate, heparan sulfate and heparin
SUBSTRATE   L-Iduronate 2-sulfate
            H2O
            Dermatan sulfate
            Heparan sulfate
            Hiparin
PRODUCT     Sulfate
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
GENES       MMU: 96417(Ids)
            HSA: 3423(IDS)
DISEASE     MIM: 309900  Iduronate 2-sulfatase (Hunter syndrome)
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.13
            ExPASy - ENZYME nomenclature database: 3.1.6.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.13
            BRENDA, the Enzyme Database: 3.1.6.13
///
ENTRY       EC 3.1.6.14
NAME        N-Acetylglucosamine-6-sulfatase
            Chondroitinsulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase
REACTION    Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine
            6-sulfate units of heparan sulfate and keratan sulfate
SUBSTRATE   N-Acetyl-D-glucosamine 6-sulfate
            Heparan sulfate
            Keratan sulfate
            H2O
PRODUCT     Sulfate
COMMENT     May be identical with EC 3.1.6.11
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
GENES       HSA: 2799(GNS)
DISEASE     MIM: 252940  N-acetylglucosamine-6-sulfatase
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.14
            ExPASy - ENZYME nomenclature database: 3.1.6.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.14
            BRENDA, the Enzyme Database: 3.1.6.14
///
ENTRY       EC 3.1.6.15
NAME        N-Sulfoglucosamine-3-sulfatase
            Chondroitinsulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Sulfo-3-sulfoglucosamine 3-sulfohydrolase
REACTION    Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine
            3-O-sulfate units of heparin
SUBSTRATE   Heparin
            H2O
PRODUCT     Heparin
            Sulfate
COMMENT     The enzyme from Flavobacterium heparinum also hydrolyses
            N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts
            only on the disulfated residue.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.15
            ExPASy - ENZYME nomenclature database: 3.1.6.15
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.15
            BRENDA, the Enzyme Database: 3.1.6.15
///
ENTRY       EC 3.1.6.16
NAME        Monomethyl-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Monomethyl-sulfate sulfohydrolase
REACTION    Monomethyl sulfate + H2O = Methanol + Sulfate
SUBSTRATE   Monomethyl sulfate
            H2O
PRODUCT     Methanol
            Sulfate
COMMENT     Highly specific; does not act on monoethyl sulfate, monoisopropyl
            sulfate or monododecyl sulfate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.16
            ExPASy - ENZYME nomenclature database: 3.1.6.16
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.16
            BRENDA, the Enzyme Database: 3.1.6.16
///
ENTRY       EC 3.1.6.17
NAME        D-Lactate-2-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     (S)-2-O-Sulfolactate 2-sulfohydrolase
REACTION    (S)-2-O-Sulfolactate + H2O = (S)-Lactate + Sulfate
SUBSTRATE   (S)-2-O-Sulfolactate
            H2O
PRODUCT     (S)-Lactate
            Sulfate
COMMENT     Highly specific.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.17
            ExPASy - ENZYME nomenclature database: 3.1.6.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.17
            BRENDA, the Enzyme Database: 3.1.6.17
///
ENTRY       EC 3.1.6.18
NAME        Glucuronate-2-sulfatase
            Chondro-2-sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase
REACTION    Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate
            residues of chondroitin sulfate, heparin and heparitin sulfate
SUBSTRATE   Chondroitin sulfate
            Heparin
            Heparitin sulfate
            H2O
PRODUCT     Chondroitin sulfate
            Heparin
            Heparitin sulfate
            Sulfate
COMMENT     Does not act on iduronate 2-sulfate residues (cf. EC 3.1.6.13).
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.6.18
            ExPASy - ENZYME nomenclature database: 3.1.6.18
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.18
            BRENDA, the Enzyme Database: 3.1.6.18
///
ENTRY       EC 3.1.7.1
NAME        Prenyl-pyrophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Diphosphoric monoester hydrolases
SYSNAME     Prenyl-diphosphate pyrophosphohydrolase
REACTION    Prenyl diphosphate + H2O = Prenol + Pyrophosphate
SUBSTRATE   Prenyl diphosphate
            H2O
            Farnesyl diphosphate
PRODUCT     Prenol
            Pyrophosphate
            Farnesol
COMMENT     Farnesyl diphosphate is the best substrate so for tested.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.7.1
            ExPASy - ENZYME nomenclature database: 3.1.7.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.7.1
            BRENDA, the Enzyme Database: 3.1.7.1
///
ENTRY       EC 3.1.7.2
NAME        Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Diphosphoric monoester hydrolases
SYSNAME     Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
REACTION    Guanosine 3',5'-bis(diphosphate) + H2O =
            Guanosine 5'-diphosphate + Pyrophosphate
SUBSTRATE   Guanosine 3',5'-bis(diphosphate)
            H2O
PRODUCT     Guanosine 5'-diphosphate
            Pyrophosphate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3650(spoT)
            ECE: Z5076(spoT)
            ECS: ECs4525
            YPE: YPO0038(spoT)
            HIN: HI1741(spoT)
            PMU: PM0920(spoT)
            XFA: XF0352
            VCH: VC2710
            PAE: PA5338(spoT)
            NME: NMB1659
            NMA: NMA1917(spoT)
            HPY: HP0775(spoT)
            HPJ: jhp0712
            CJE: Cj1272c(spoT)
            CCR: CC1553
            MGE: MG278(spot)
            MPN: F11_orf733(spoT)
            UUR: UU283(spoT/relA)
            BBU: BB0198(spoT)
            SYN: slr1325(spoT)
            AAE: aq_844(spoT)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.7.2
            ExPASy - ENZYME nomenclature database: 3.1.7.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.7.2
            BRENDA, the Enzyme Database: 3.1.7.2
///
ENTRY       EC 3.1.7.3
NAME        Monoterpenyl-pyrophosphatase
            Bornyl pyrophosphate hydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Diphosphoric monoester hydrolases
SYSNAME     Monoterpenyl-diphosphate pyrophosphohydrolase
REACTION    Monoterpenyl diphosphate + H2O = Monoterpenol + Pyrophosphate
SUBSTRATE   Monoterpenyl diphosphate
            H2O
PRODUCT     Monoterpenol
            Pyrophosphate
COMMENT     A group of enzymes with varying specificity for the monoterpenol
            moiety. One has the highest activity on sterically-hindered
            compounds such as (+)-bornyl diphosphate; another has highest
            activity on the diphosphates of primary allylic alcohols such as
            geraniol.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.7.3
            ExPASy - ENZYME nomenclature database: 3.1.7.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.7.3
            BRENDA, the Enzyme Database: 3.1.7.3
///
ENTRY       EC 3.1.8.1
NAME        Aryldialkylphosphatase
            Organophosphate hydrolase
            Paraoxonase
            A-esterase
            Aryltriphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric triester hydrolases
SYSNAME     Aryltriphosphate dialkylphosphohydrolase
REACTION    an Aryl dialkyl phosphate + H2O =
            Dialkyl phosphate + an Aryl alcohol
SUBSTRATE   Aryl dialkyl phosphate
            H2O
            Ester of phosphonic acid
            Ester of phosphinic acid
INHIBITOR   Chelating agent
COFACTOR    Divalent cation
PRODUCT     Dialkyl phosphate
            Aryl alcohol
COMMENT     Acts on organophosphorus compounds (such as paraoxon) including
            esters of phosponic and phosphinic acids. Inhibited by chelating
            agents; requires divalent cations for activity. Previously
            registered as identical with EC 3.1.1.2.
GENES       HSA: 5444(PON1) 5445(PON2)
DISEASE     MIM: 168820  Paraoxonase-1
MOTIF       PS: PS01322  G-x-T-L-x-H-E-H-[LIV]
            PS: PS01323  A-x-A-x-A-x(4)-G-x-P-[LIVM]-x(2)-H
STRUCTURES  PDB: 1JGM  1EYW  1I0D  1I0B  1HZY  1EZ2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.8.1
            ExPASy - ENZYME nomenclature database: 3.1.8.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.8.1
            UM-BBD (Biocatalysis/Biodegradation Database): 3.1.8.1
            BRENDA, the Enzyme Database: 3.1.8.1
            SCOP (Structural Classification of Proteins): 3.1.8.1
///
ENTRY       EC 3.1.8.2
NAME        Diisopropyl-fluorophosphatase
            DFPase
            Tabunase
            Somanase
            Organophosphorus acid anhydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric triester hydrolases
SYSNAME     Diisopropyl-fluorophosphate fluorohydrolase
REACTION    Diisopropyl fluorophosphate + H2O = Diisopropyl phosphate +
            Fluoride
SUBSTRATE   Diisopropyl fluorophosphate
            H2O
PRODUCT     Diisopropyl phosphate
            Fluoride
INHIBITOR   Chelating agent
COFACTOR    Divalent cation
COMMENT     Acts on phosphorus anhydride bonds (such as phosphorus-halide and
            phosphorus-cyanide) in organophosphorus compounds (including)
            'nerve gases'). Inhibited by chelating agents; requires divalent
            cations. Related to EC 3.1.8.1. Previously listed as EC 3.8.2.1.
STRUCTURES  PDB: 1E1A  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.8.2
            ExPASy - ENZYME nomenclature database: 3.1.8.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.8.2
            BRENDA, the Enzyme Database: 3.1.8.2
///
ENTRY       EC 3.1.11.1
NAME        Exodeoxyribonuclease I
            E.coli exonuclease I
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   Deoxyribonucleotide
            Single-stranded DNA
            Glucosylated DNA
            H2O
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for single-stranded DNA. The E. coli enzyme hydrolyses
            glucosylated DNA. Similar enyzmes: Mammalian DNase III;
            Exonuclease IV; T2- and T4-induced exodeoxyribonucleases. Formerly
            EC 3.1.4.25.
GENES       ECO: b2011(sbcB)
            ECE: Z3173(sbcB)
            ECS: ECs2813
            YPE: YPO1558(sbcB)
            HIN: HI1377(sbcB)
            PMU: PM0611(sbcB)
            XFA: XF2022
            VCH: VC1234
            PAE: PA4316(sbcB)
            BUC: BU555(sbcB)
STRUCTURES  PDB: 1FXX  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.1
            ExPASy - ENZYME nomenclature database: 3.1.11.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.1
            BRENDA, the Enzyme Database: 3.1.11.1
            SCOP (Structural Classification of Proteins): 3.1.11.1
///
ENTRY       EC 3.1.11.2
NAME        Exodeoxyribonuclease III
            E.coli exonuclease III
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   Deoxyribonucleotide
            Double-stranded DNA
            H2O
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for double-stranded DNA. Has endonucleolytic activity
            near apurinic sites on DNA. Similar enzyme: Haemophilus influenzae
            exonuclease. Formerly EC 3.1.4.27.
GENES       ECO: b1749(xthA)
            ECE: Z2781(xthA)
            ECS: ECs2455
            YPE: YPO2168(xthA)
            HIN: HI0041(xthA)
            PMU: PM0691
            XFA: XF0164 XF1933
            VCH: VC1860
            PAE: PA2545(xthA) PA4172 PA5332(crc)
            NME: NMB0399 NMB2082
            NMA: NMA0348 NMA2086(xthA)
            HPY: HP1526(lexA)
            HPJ: jhp1415
            CJE: Cj0255c
            RPR: RP260(xthA1) RP676(xthA2)
            RCO: RC0346(xthA1) RC1028(xthA2)
            MLO: mll2070 mll4241 mlr1096
            SME: SMb20689(xthA4) SMc00956(xthA1) SMc02077(xthA2)
                 SMc03818(xthA3)
            CCR: CC2011 CC3706
            BSU: BG10046(exoA)
            LLA: L198056(exoA)
            SPY: SPy0412(exoA)
            SPN: SP1845
            SPR: spr1660(exoA)
            CAC: CAC0222(exoA)
            MTU: Rv0427c(xthA)
            MTC: MT0442
            BBU: BB0534(exoA)
            TPA: TP0125
            SYN: sll1854(xthA)
            DRA: DR0354
            MTH: MTH212
            AFU: AF0580(xthA)
            TAC: Ta1506
            TVO: TVG0048222
            SSO: SSO2290
            CEL: R09B3.1
MOTIF       PS: PS00726  [APF]-D-[LIVMF](2)-x-[LIVM]-Q-E-x-K
            PS: PS00727  D-[ST]-[FY]-R-[KH]-x(7,8)-[FYW]-[ST]-[FYW](2)
            PS: PS00728  N-x-G-x-R-[LIVM]-D-[LIVMFYH]-x-[LV]-x-S
STRUCTURES  PDB: 1AKO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.2
            ExPASy - ENZYME nomenclature database: 3.1.11.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.2
            BRENDA, the Enzyme Database: 3.1.11.2
            SCOP (Structural Classification of Proteins): 3.1.11.2
///
ENTRY       EC 3.1.11.3
NAME        Exodeoxyribonuclease (lambda-induced)
            Lambda exonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 5'- to 3'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   DNA
            H2O
PRODUCT     5'-Phosphomononucleotides
COMMENT     Preference for double-stranded DNA.  Does not attack
            single-strand breaks.  Similar ezyme: T4, T5 and T7 exonucleases;
            Mammalian DNase IV.  Formerly EC 3.1.4.28.
STRUCTURES  PDB: 1AVQ  1EXN  1XO1  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.3
            ExPASy - ENZYME nomenclature database: 3.1.11.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.3
            BRENDA, the Enzyme Database: 3.1.11.3
            SCOP (Structural Classification of Proteins): 3.1.11.3
///
ENTRY       EC 3.1.11.4
NAME        Exodeoxyribonuclease (phage SP3-induced)
            Phage SP3 DNase
            DNA 5'-dinucleotidohydrolase
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 5'- to 3'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   DNA
            H2O
PRODUCT     5'-Phosphomononucleotides
COMMENT     Preference for single-stranded DNA.  Formerly EC 3.1.4.31.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.4
            ExPASy - ENZYME nomenclature database: 3.1.11.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.4
            BRENDA, the Enzyme Database: 3.1.11.4
///
ENTRY       EC 3.1.11.5
NAME        Exodeoxyribonuclease V
            E.coli exonuclease V
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage (in presence of ATP) in either 5'- to 3'-
            or 3'- to 5'-direction to yield 5'-phosphooligonucleotides
SUBSTRATE   Deoxyribonucleotide
            Double-stranded DNA
            Single-stranded DNA
            H2O
            ATP
PRODUCT     5'-Phosphooligonucleotide
            ADP
            Orthophosphate
COFACTOR    ATP
COMMENT     Preference for double-stranded DNA. Possesses DNA-dependent ATPase
            activity. Acts endonucleolytically on single-stranded circular
            DNA. Similar enzyme: Haemophilus influenzae ATP-dependent DNase.
GENES       ECO: b2819(recD) b2820(recB) b2822(recC)
            ECE: Z4136(recD) Z4137(recB) Z4139(recC)
            ECS: ECs3676 ECs3677 ECs3679
            YPE: YPO1018(recC) YPO1020(recB) YPO1021(recD)
            HIN: HI0942(recC) HI1321(recB) HI1322(recD)
            PMU: PM0516(recB) PM0517(recD) PM0961(recC)
            XFA: XF0422 XF0423 XF0425
            VCH: VC2319 VC2320 VC2322
            PAE: PA4283(recD) PA4284(recB) PA4285(recC)
            BUC: BU453(recC) BU454(recB) BU455(recD)
            NME: NMB0785 NMB1233 NMB1720
            NMA: NMA0995(recB) NMA1401(recD) NMA1974(recC)
            BSU: BG13789(yrrC)
            SAU: SA1447
            SAV: SAV1607
            LLA: L180415(recD)
            SPY: SPy1844
            SPN: SP0401
            SPR: spr0363(recD)
            CAC: CAC1143(recD) CAC2854(recD)
            MPU: MYPU_7820(recD)
            MTU: Rv0629c(recD) Rv0630c(recB) Rv0631c(recC)
            MTC: MT0657 MT0658 MT0659
            CTR: CT033 CT639 CT640 CT652
            CMU: TC0007 TC0008 TC0021 TC0302
            CPN: CPn0123 CPn0737 CPn0738 CPn0752
            CPA: CP0007 CP0008 CP0650 CP1120
            CPJ: recB recC recD_1 recD_2
            BBU: BB0632(recD) BB0633(recB) BB0634(recC)
            DRA: DR1902
            AAE: aq_388
            MJA: MJ1519(recD)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.5
            ExPASy - ENZYME nomenclature database: 3.1.11.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.5
            BRENDA, the Enzyme Database: 3.1.11.5
///
ENTRY       EC 3.1.11.6
NAME        Exodeoxyribonuclease VII
            E.coli exonuclease VII
CLASS       Hydrolases
            Acting on ester bonds
            Exodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in either 5'- to 3'- or 3'- to
            5'-direction to yield 5'-phosphomononucleotides.
SUBSTRATE   Nucleotide
            H2O
            Single-stranded DNA
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for single-stranded DNA. Similar enzyme: Micrococcus
            luteus exonuclease.
GENES       ECO: b0422(xseB) b2509(xseA)
            ECE: Z0525(xseB) Z3773(xseA)
            ECS: ECs0476 ECs3371
            YPE: YPO2872(xseA) YPO3175(xseB)
            HIN: HI0397(xseA) HI1437(xseB)
            PMU: PM0168(xseA) PM0534(xseB)
            XFA: XF0660 XF0755
            VCH: VC0766 VC0891
            PAE: PA3777(xseA) PA4042(xseB)
            NME: NMB0262 NMB1363
            NMA: NMA1575(xseA) NMA2225(xseB)
            HPY: HP0259(xseA)
            HPJ: jhp0243
            CJE: Cj0325(xseA)
            RPR: RP350(xseB) RP675(xseA)
            RCO: RC0475(xseB) RC1026(xseA)
            MLO: mll6896 msr7470
            SME: SMc00378 SMc00970
            CCR: CC2070 CC2246
            BSU: BG11712(xseA) BG11713(xseB)
            BHA: BH2782 BH2783
            SAU: SA1353 SA1354
            SAV: SAV1511 SAV1512
            LLA: L0254(xseA) L0255(xseB)
            SPY: SPy1499(xseB) SPy1500(xseA)
            SPN: SP1206 SP1207
            SPR: spr1088(xseB) spr1089(xseA)
            CAC: CAC2081(xseB) CAC2082(xseA)
            MTU: Rv1107c(xseB) Rv1108c(xseA)
            MTC: MT1138 MT1139
            MLE: ML1940(xseA) ML1941(xseB)
            CTR: CT329
            CMU: TC0605 TC0606
            CPN: CPn1062
            CPA: CP0787 CP0788
            CPJ: xseA
            DRA: DR0186
            TMA: TM1768 TM1769
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.11.6
            ExPASy - ENZYME nomenclature database: 3.1.11.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.11.6
            BRENDA, the Enzyme Database: 3.1.11.6
///
ENTRY       EC 3.1.13.1
NAME        Exoribonuclease II
            Ribonuclease II
CLASS       Hydrolases
            Acting on ester bonds
            Exoribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides
SUBSTRATE   DNA
            H2O
PRODUCT     3'-Phosphomononucleotides
COMMENT     Preference for single-stranded RNA.  The enzyme processes
            3'-terminal extra-nucleotides of monomeric tRNA precursors,
            following the action of EC 3.1.26.5.  Similar enzymes: RNase Q;
            RNase BN; RNase PIII; RNase Y.  Formerly EC 3.1.4.20.
GENES       ECO: b1286(rnb)
            ECE: Z2514(rnb)
            ECS: ECs1859
            YPE: YPO2235(rnb)
            HIN: HI1733(rnb)
            PMU: PM0181(rnb)
            VCH: VCA0805
            BUC: BU266(rnb)
            SME: SMc00734
            MPU: MYPU_3510(vacB)
            TPA: TP0805
            SYN: sll1290(rnb)
MOTIF       PS: PS01175  [HI]-[FYE]-[GSTAM]-[LIVM]-x(4,5)-Y-[STALV]-x-[FWVAC]-
                         [TV]-[SA]-P-[LIVMA]-[RQ]-[KR]-[FY]-x-D-x(3)-[HQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.13.1
            ExPASy - ENZYME nomenclature database: 3.1.13.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.13.1
            BRENDA, the Enzyme Database: 3.1.13.1
///
ENTRY       EC 3.1.13.2
NAME        Exoribonuclease H
CLASS       Hydrolases
            Acting on ester bonds
            Exoribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in
            both 5'- to 3'- and 3'- to 5'-directions.
SUBSTRATE   RNA
            H2O
PRODUCT     5'-Phosphomonoester oligonucleotides
COMMENT     Attacks RNA in duplex with DNA strand.  Found in certain oncorna
            viruses and animal cells.
GENES       DME: CG8729(rnh1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.13.2
            ExPASy - ENZYME nomenclature database: 3.1.13.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.13.2
            BRENDA, the Enzyme Database: 3.1.13.2
///
ENTRY       EC 3.1.13.3
NAME        Oligonucleotidase
CLASS       Hydrolases
            Acting on ester bonds
            Exoribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage of oligonucleotides to yield
            5'-phosphomononucleotides
SUBSTRATE   Oligonucleotide
            NAD+
            H2O
PRODUCT     5'-Phosphomononucleotide
            NMN
            AMP
COMMENT     Also hydrolyses NAD+ to NMN and AMP.  Formerly EC 3.1.4.19.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.13.3
            ExPASy - ENZYME nomenclature database: 3.1.13.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.13.3
            BRENDA, the Enzyme Database: 3.1.13.3
///
ENTRY       EC 3.1.13.4
NAME        Poly(A)-specific ribonuclease
            3'-Exoribonuclease
            2',3'-Exoribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Exoribonucleases producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage of poly(A) to 5'-AMP
SUBSTRATE   Poly(A)
            H2O
PRODUCT     Poly(A)
            5'-AMP
COMMENT     Cleaves poly(A) in either the single- or double-stranded-form.
GENES       SCE: YGL094C(PAN2) YKL025C(PAN3)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.13.4
            ExPASy - ENZYME nomenclature database: 3.1.13.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.13.4
            BRENDA, the Enzyme Database: 3.1.13.4
///
ENTRY       EC 3.1.14.1
NAME        Yeast ribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Exoribonucleases producing other than 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage to 3'-phosphomononucleotides
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
COMMENT     Similar enzyme: RNase U4.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.14.1
            ExPASy - ENZYME nomenclature database: 3.1.14.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.14.1
            BRENDA, the Enzyme Database: 3.1.14.1
///
ENTRY       EC 3.1.15.1
NAME        Venom exonuclease
            Venom phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Exonucleases active with either ribo- or deoxyribonucleic acids
            and producing 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 3'- to 5'-direction to yield
            5'-phosphomononucleotides.
SUBSTRATE   Nucleotide
            H2O
            Single-stranded nucleotide
PRODUCT     5'-Phosphomononucleotide
COMMENT     Preference for single-stranded substrate. Similar enzymes: Hog
            kidney phosphodiesterase; Lactobacillus exonuclease.
            This enzyme has a 500-1,700-fold greater activity on R(p) isomers
            of RNA containing phosphorothioate such as U-P(S)-A and A-P(S)-A
            than S(p) isomers.  Review: 'Stereochemistry of enzymatic reaction
            of phosphates', P.A.Frey, Tetrahedron 38, 1541 (1982).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.15.1
            ExPASy - ENZYME nomenclature database: 3.1.15.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.15.1
            BRENDA, the Enzyme Database: 3.1.15.1
///
ENTRY       EC 3.1.16.1
NAME        Spleen exonuclease
            3'-Exonuclease
            Spleen phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Exonucleases active with either ribo- or deoxyribonucleic acids
            and producing other than 5'-phosphomonoesters
REACTION    Exonucleolytic cleavage in the 5'- to 3'-direction to yield
            3'-phosphomononucleotides
SUBSTRATE   RNA
            DNA
            H2O
PRODUCT     3'-Phosphomononucleotide
COMMENT     Preference for single-stranded substrate.  Similar enzymes:
            Lactobacillus acidophilus nuclease; B. subtilis nuclease; Salmon
            testis nuclease.  Formerly EC 3.1.4.18. (cf. EC 3.1.31.1).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.16.1
            ExPASy - ENZYME nomenclature database: 3.1.16.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.16.1
            BRENDA, the Enzyme Database: 3.1.16.1
///
ENTRY       EC 3.1.21.1
NAME        Deoxyribonuclease I
            Pancreatic DNase
            DNase
            Thymonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphodinucleotide and
            5'-phosphooligonucleotide end-products
SUBSTRATE   DNA
            H2O
            Double-stranded DNA
PRODUCT     5'-Phosphodinucleotide
            5'-Phosphooligonucleotide
COMMENT     Preference for double-stranded DNA. Similar enzymes: Streptococcal
            DNase (Streptodornase); T4 endonuclease II; T7 endonuclease II; E.
            coli endonuclease I; "Nicking" enzyme of calf thymus; Colicin E2
            and E3. Formerly EC 3.1.4.5.
GENES       ECO: b2945(endA)
            ECE: Z4290(endA)
            ECS: ECs3821
            YPE: YPO0933(endA)
            PAE: PA1150(pys2) PA2749(endA)
            BUC: BU409(endA)
            MMU: 103157(Dnl1)
            HSA: 1773(DNASE1)
DISEASE     MIM: 125505  Deoxyribonuclease I
MOTIF       PS: PS00918  G-D-F-N-A-x-C-[SA]
            PS: PS00919  [LIVM](2)-[AP]-[LQ]-H-[STA](2)-P-x(5)-E-[LIVM]-[DN]-x-
                         L-x-[DE]-V
STRUCTURES  PDB: 1DNK  1EMV  2DNJ  3DNI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.1
            ExPASy - ENZYME nomenclature database: 3.1.21.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.1
            BRENDA, the Enzyme Database: 3.1.21.1
            SCOP (Structural Classification of Proteins): 3.1.21.1
///
ENTRY       EC 3.1.21.2
NAME        Deoxyribonuclease IV (Phage-T4-induced)
            Endodeoxyribonuclease IV (Phage T4-induced)
            E.coli endonuclease IV
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products
SUBSTRATE   DNA
            H2O
            Single-stranded DNA
PRODUCT     5'-Phosphooligonucleotide
COMMENT     Preference for single-stranded DNA. Similar enzymes: DNase V
            (mammalian); Aspergillus sojae DNase; B. subtillis endonuclease;
            T4 endonuclease III; T7 endonuclease I; Aspergillus DNase K2;
            Vaccinia virus DNase VI; Yeast DNase; Chorella DNase. Formerly
            EC 3.12.4.30.
GENES       ECO: b2159(nfo)
            ECE: Z3416(nfo)
            ECS: ECs3051
            YPE: YPO1306(nfo)
            VCH: VC2360
            BUC: BU137(nfo)
            BSU: BG11665(yqfS)
            BHA: BH1386
            SAU: SA1386
            SAV: SAV1546
            CAC: CAC1632
            MGE: MG235(nfo)
            MPN: F10_orf286(nfo)
            MPU: MYPU_6210(nfo)
            UUR: UU306(nfo)
            MTU: Rv0670(end)
            MTC: MT0699
            MLE: ML1889
            CTR: CT625
            CMU: TC0914
            CPN: CPn0732
            CPA: CP0014
            CPJ: nfo
            AAE: aq_1629(nfo)
            TMA: TM0362
            MJA: MJ0133
            MTH: MTH1010
            HAL: VNG0183G(xthA)
            TAC: Ta0891
            TVO: TVG1022523
            PHO: PH1905
            PAB: PAB1103
            APE: APE2104
            SSO: SSO2156
MOTIF       PS: PS00729  H-[GSAD]-x-Y-[LIF]-[LIMN]-N-[LIVMFCAP]-[AGC]
            PS: PS00730  [GSAR]-[LIVMF]-C-[LIVMFY]-D-T-C-H
            PS: PS00731  [LIVMFW]-H-x-N-[DE]-[SA]-x(4)-[GN]-x(3)-D-x-H
STRUCTURES  PDB: 1QTW  1FZR  1QUM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.2
            ExPASy - ENZYME nomenclature database: 3.1.21.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.2
            BRENDA, the Enzyme Database: 3.1.21.2
            SCOP (Structural Classification of Proteins): 3.1.21.2
///
ENTRY       EC 3.1.21.3
NAME        Type I site-specific deoxyribonuclease
            Type I restrinction enzyme
            Deoxyribonuclease (ATP- and S-adenosyl-L-methione-dependent)
            Restriction-Modification system
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of DNA to give random double-stranded
            fragments with terminal 5'-phosphates; ATP is simultaneously
            hydrolysed.
SUBSTRATE   DNA
            ATP
            H2O
            dATP
PRODUCT     DNA
            ADP
            Orthophosphate
COFACTOR    S-Adenosyl-L-methionine
COMMENT     This is a large group of enzymes which, together with those now
            listed as EC 3.1.21.4 and 3.1.21.5, were previously listed
            separately in sub-subclasses 3.1.23 and 3.1.24. They have an
            absolute requirement for ATP (or dATP) and
            S-adenosyl-L-methionine. They recognize specific short DNA
            sequences and cleave at sites remote from the recognition
            sequence. They are multifunctional proteins which also catalyse
            the reactions of EC 2.1.1.72 and 2.1.1.73, with similar site
            specificity. A complete listing of all these enzymes
            has been produced by R.J.Roberts; this list is updated annually.
GENES       ECO: b4348(hsdS) b4350(hsdR)
            ECE: Z5948
            ECS: ECs5308
            HIN: HI0216(hsdS) HI1285(hsdR) HI1286
            PMU: PM1541(hsdR)
            XFA: XF0296 XF2721 XF2722 XF2725 XF2726 XF2739 XF2741
            VCH: VC1765 VC1768
            PAE: PA2732 PA2734
            NME: NMB0835
            HPY: HP0462(hsdS) HP0464(hsdR) HP0846(hsdR) HP0848(hsdS) HP1383
                 HP1402(hsdR) HP1404(hsdS)
            HPJ: jhp0414 jhp0726 jhp0784 jhp0785 jhp1422 jhp1424
            CJE: Cj1549c Cj1551c
            SME: SMc02292(hsdR)
            CCR: CC0621 CC0623
            SAU: SA0189(hsdR) SA0392(hsdS) SA1625
            SAV: SAV0190(hsdR) SAV0421(hsdS) SAV1793
            LLA: L0308(hsdR) L0310(hsdS)
            SPY: SPy1904(hsdR) SPy1905(hsdS)
            SPN: SP0510 SP0892
            SPR: spr0446(hsdS) spr0448(hsdS) spr0450(hsdR) spr0792(hsdR)
            MPN: C12_orf249(hsdS) H91_orf206(hsdR) H91_orf330 H91_orf376(hsdR)
                 P02_orf363V R02_orf335(hsdS)
            MPU: MYPU_0770(hsdR) MYPU_0780(hsdR) MYPU_0830(hsdS)
                 MYPU_4310(hsdS) MYPU_4320(hsdR) MYPU_4340(hsdS)
                 MYPU_6760(hsdS) MYPU_6770(hsdR) MYPU_6790(hsdS)
            UUR: UU095(hsdR) UU096(hsdS-1) UU097(hsdS-2) UU099(hsdS-3)
            MJA: MJ0124 MJ0130 MJ1214 MJ1218 MJ1531 MJECL40 MJECL41
            MTH: MTH940 MTH941
            AFU: AF1708 AF1710
            HAL: VNG0107G(rmeS) VNG0108G(rmeR)
            PAB: PAB2150 PAB2154
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.3
            ExPASy - ENZYME nomenclature database: 3.1.21.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.3
            BRENDA, the Enzyme Database: 3.1.21.3
///
ENTRY       EC 3.1.21.4
NAME        Type II site-specific deoxyribonuclease
            Type II restriction enzyme
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of DNA to give specific double-stranded
            fragments with terminal 5'-phosphates
SUBSTRATE   DNA
            H2O
PRODUCT     DNA 5'-phosphate
COFACTOR    Magnesium
COMMENT     This is a large group of enzymes which, together with those now
            listed as EC 3.1.21.3 and 3.1.21.5, were previously listed
            separately in sub-subclasses 3.1.23 and 3.1.24. They require only
            Mg2+. They recognize specific short DNA sequences and cleave
            either within, or at a short specific distance from, the
            recognition site. A complete listing of all these enzymes has been
            produced by R.J.Roberts; this list is updated annually.
            Roberts,R.J.(1983) Nucleic Acids Res., 11, r135.
GENES       HIN: HI0512(hinDIIR) HI1040 HI1393(hinDIIIR)
            NME: NMB1289
            NMA: NMA1499
            HPY: HP0091(hsdR) HP1209(iceA) HP1366(MBOIIR)
            HPJ: jhp1442
            SPN: SP1850
            SPR: spr1101 spr1102 spr1285 spr1286 spr1665(dpnC)
            MJA: MJ0600 MJ0984 MJ1208.
MOTIF       PS: PS00092  [LIVMAC]-[LIVFYWA]-x-[DN]-P-P-[FYW]
STRUCTURES  PDB: 1B95  1AZ0  1AZ3  1AZ4  1B94  1B96  1B97  1BAM  1BGB  1BHM  
                 1BSS  1BSU  1BUA  1CFR  1D02  1DC1  1DMU  1EO3  1EO4  1EON  
                 1EOO  1EOP  1ERI  1ESG  1EV7  1EYU  1F0O  1FIU  1FOK  1IAW  
                 1JIM  1PVU  1QC9  1RV5  1RVA  1RVB  1RVC  1RVE  2BAM  2PVI  
                 3BAM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.4
            ExPASy - ENZYME nomenclature database: 3.1.21.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.4
            BRENDA, the Enzyme Database: 3.1.21.4
            SCOP (Structural Classification of Proteins): 3.1.21.4
///
ENTRY       EC 3.1.21.5
NAME        Type III site-specific deoxyribonuclease
            Type III restriction enzyme
            Restriction-Modification system
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of DNA to give specific double-stranded
            fragments with terminal 5'-phosphates
SUBSTRATE   DNA
            H2O
PRODUCT     DNA 5'-phosphate
COFACTOR    ATP
            S-Adenosyl-L-methionine
COMMENT     This is a large group of enzymes which, together with those now
            listed as EC 3.1.21.3 and 3.1.21.4, were previously listed
            separately in sub-subclasses 3.1.23 and 3.1.24. They have an
            absolute requirement for ATP, but do not hydrolyse it;
            S-Adenosyl-L-methionine stimulates the reaction, but is not
            absolutely required. They recognize specific short DNA sequences
            and cleave a short distance away from the recognition sequence.
            These enzymes exist as complexes with enzymes of similar
            specificity listed under EC 2.1.1.72 or 2.1.1.73. A complete
            listing of all these enzymes has been produced by R.J.Roberts;
            this list is updated annually.
GENES       NME: NMB1260
            NMA: NMA1466
            HPY: HP0592(res) HP1521(res)
            HPJ: jhp1410
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.5
            ExPASy - ENZYME nomenclature database: 3.1.21.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.5
            BRENDA, the Enzyme Database: 3.1.21.5
///
ENTRY       EC 3.1.21.6
NAME        CC-Preferring endodeoxyribonuclease
            5'-CC-3'-Preferring ensodeoxyribonuclease
            Streptomyces glaucescens exocytoplasmic endonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to give 5'-Phosphooligonucleotide
            end-products. The enzyme shows a preference toward cleavage within
            the Dinucleotide CC.
COMMENT     Prefers CC sites in Double-stranded circular and linear DNA.
            Greater affinity for Double-stranded than Single-stranded DNA.
            Produces NICS, genarating Double-stranded fragments with 5'- and/or
            3'-Protuding Single-stranded tails.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.21.6
            ExPASy - ENZYME nomenclature database: 3.1.21.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.21.6
///
ENTRY       EC 3.1.22.1
NAME        Deoxyribonuclease II
            DNase II
            Pancreatic DNase II
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotide and
            3'-phosphooligonucleotide end-products.
SUBSTRATE   DNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Preference for double-stranded DNA.  Similar enzymes Crab testis
            DNase; Snail DNase; Slamon testis DNase; Liver acid DNase; Human
            acid DNases of gastric mucosa and cervix.  Formerly EC 3.1.4.6.
GENES       HSA: 1777(DNASE2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.22.1
            ExPASy - ENZYME nomenclature database: 3.1.22.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.1
            BRENDA, the Enzyme Database: 3.1.22.1
///
ENTRY       EC 3.1.22.2
NAME        Aspergillus deoxyribonuclease K1
            Aspergillus DNase K1
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotide and
            3'-phosphooligonucleotide end-products
SUBSTRATE   DNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Preference for single-stranded DNA.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.22.2
            ExPASy - ENZYME nomenclature database: 3.1.22.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.2
            BRENDA, the Enzyme Database: 3.1.22.2
///
ENTRY       EC 3.1.22.3
NAME        Deoxyribonuclease V
            Endodeoxyribonuclease V
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage at apurinic or apyrimidinic sites to
            to products with a 3'-phosphate.
SUBSTRATE   DNA
            H2O
PRODUCT     3'-Phosphooligonucleotide
COMMENT     Similar enzymes: Thymus endonuclease; E. coli endonuclease II;
            Human placenta endonuclease.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.22.3
            ExPASy - ENZYME nomenclature database: 3.1.22.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.3
            BRENDA, the Enzyme Database: 3.1.22.3
///
ENTRY       EC 3.1.22.4
NAME        Crossover junction endoribonuclease
            Holliday junction nuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage at a junction such as reciprocal
            single-stranded crossover between two homologous DNA duplexes
            (Holliday junction).
SUBSTRATE   DNA (containing Holliday junction)
            H2O
PRODUCT     DNA
COMMENT     No endonuclease or exonuclease activity on single-stranded or
            double-stranded DNA molecules that do not contain Holliday
            junctions. From Saccharomyces cerevisiae.
GENES       ECO: b1863(ruvC)
            ECE: Z2915(ruvC)
            ECS: ECs2573
            YPE: YPO2056(ruvC)
            HIN: HI0314(ruvC)
            PMU: PM0978(ruvC)
            XFA: XF1905
            VCH: VC1847
            PAE: PA0965(ruvC)
            NME: NMB1419
            NMA: NMA1631(ruvC)
            HPY: HP0877(ruvC)
            HPJ: jhp0811
            CJE: Cj1731c(ruvC)
            RPR: RP119(ruvC)
            RCO: RC0159(ruvC)
            MLO: mll3901(ruvC)
            SME: SMc03967(ruvC)
            CCR: CC3238
            MTU: Rv2594c(ruvC)
            MTC: MT2671
            MLE: ML0481(ruvC)
            CTR: CT502
            CMU: TC0789
            CPN: CPn0621
            CPA: CP0126
            CPJ: ruvC
            TPA: TP0517
            SYN: sll0896(ruvC)
            DRA: DR0440
            TMA: TM0575
MOTIF       PS: PS01321  G-x-[GA]-x-A-x-K-x-[EQ]-[IV]-x(16,19)-D-x-[SAV]-D-A-x-
                         A-[LIVM]-A
STRUCTURES  PDB: 1HJR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.22.4
            ExPASy - ENZYME nomenclature database: 3.1.22.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.4
            BRENDA, the Enzyme Database: 3.1.22.4
            SCOP (Structural Classification of Proteins): 3.1.22.4
///
ENTRY       EC 3.1.22.5
NAME        Deoxyribonuclease X
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA
            duplexes.
SUBSTRATE   Supercoiled plasma DNA
            H2O
PRODUCT     Linear DNA duplexes
INHIBITOR   Single-stranded DNA
            ATP
            AMP
COMMENT     Preference for supercoiled DNA; little activity on linear double-
            -stranded DNA. Inhibited by single-stranded DNA, ATP and AMP.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.22.5
            ExPASy - ENZYME nomenclature database: 3.1.22.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.5
            BRENDA, the Enzyme Database: 3.1.22.5
///
ENTRY       EC 3.1.25.1
NAME        Deoxyribonuclease (pyrimidine dimer)
            Endodeoxyribonuclease (pyrimidine dimer)
CLASS       Hydrolases
            Acting on ester bonds
            Site-specific endodeoxyribonucleases specific for altered bases
REACTION    Endonucleolytic cleavage near pyrimidine dimers to products with
            5'-phosphate.
SUBSTRATE   DNA
            H2O
PRODUCT     DNA 5'-phosphate
COMMENT     Acts on a damaged strand, 5' from the damaged site. Similar
            enzymes: T4 endonuclease V; E. coli endonucleases III and V;
            Correndonuclease II.
STRUCTURES  PDB: 1ENI  1ENJ  1ENK  1VAS  2END  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.25.1
            ExPASy - ENZYME nomenclature database: 3.1.25.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.25.1
            BRENDA, the Enzyme Database: 3.1.25.1
            SCOP (Structural Classification of Proteins): 3.1.25.1
///
ENTRY       EC 3.1.25.2
NAME        Transferred to EC 4.2.99.18
CLASS       Hydrolases
            Acting on ester bonds
            Site-specific endodeoxyribonucleases specific for altered bases
COMMENT     Transferred entry. Now EC 4.2.99.18 - DNA-(apurinic or
            apyrimidinic site) lyase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.25.2
            ExPASy - ENZYME nomenclature database: 3.1.25.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.25.2
///
ENTRY       EC 3.1.26.1
NAME        Physarum polycephalum ribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester.
SUBSTRATE   RNA
            H2O
PRODUCT     5'-Phosphomonoester
COMMENT     Similar enzymes: Pig liver nuclease; HeLa cell RNase;
            E. coli RNase; Bovine adrenal cortex RNase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.1
            ExPASy - ENZYME nomenclature database: 3.1.26.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.1
            BRENDA, the Enzyme Database: 3.1.26.1
///
ENTRY       EC 3.1.26.2
NAME        Ribonuclease alpha
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester
SUBSTRATE   RNA
            O-Methylated RNA
            H2O
PRODUCT     5'-Phosphomonoester
COMMENT     Specific for O-methylated RNA.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.2
            ExPASy - ENZYME nomenclature database: 3.1.26.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.2
            BRENDA, the Enzyme Database: 3.1.26.2
///
ENTRY       EC 3.1.26.3
NAME        Ribonuclease III
            RNase O
            RNase D
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester
SUBSTRATE   RNA
            H2O
            Double-stranded DNA
PRODUCT     RNA 5'-phosphate
COMMENT     Cleaves multimeric tRNA precursor at the spacer region; involved
            also in processing of precursor rRNA, hnRNA and early T7-mRNA.
            Also cleaves double-stranded DNA.
GENES       ECO: b1804(rnd) b2567(rnc)
            ECE: Z2847(rnd) Z3848(rnc)
            ECS: ECs2513 ECs3433
            YPE: YPO2075(rnd) YPO2718(rnc)
            HIN: HI0014(rnc) HI0390(rnd)
            PMU: PM0061(rnc) PM0706(rnd)
            XFA: XF0751 XF2246
            VCH: VC1984 VC2461
            PAE: PA0770(rnc) PA1294(rnd)
            BUC: BU258(rnc)
            NME: NMB0686
            NMA: NMA0888(rnc)
            HPY: HP0662(rnc)
            HPJ: jhp0607
            CJE: Cj1635c(rnc)
            RPR: RP117(rnc)
            RCO: RC0157(rnc) RC0587(rnd2) RC0696(rnd)
            MLO: mll8354 mlr7765
            SME: SMc00622(rnd) SMc02652(rnc)
            CCR: CC1560 CC1704
            BSU: BG11537(rncS)
            BHA: BH2489(rncS)
            SAU: SA1076(rnc)
            SAV: SAV1220(rnc)
            LLA: L0326(rnc)
            SPY: SPy0531(acpA)
            SPN: SP1248
            SPR: spr1127(rncS)
            CAC: CAC1748(rncS)
            MGE: MG367(rnc)
            MPN: G12_orf282a(rnc)
            MPU: MYPU_1630(rnc)
            UUR: UU205(rnc)
            MTU: Rv2925c(rnc)
            MTC: MT2995
            MLE: ML1659(rnc)
            CTR: CT297
            CMU: TC0570
            CPN: CPn0054
            CPA: CP0721
            CPJ: rnc
            BBU: BB0705(rnc)
            TPA: TP0809
            SYN: sll0320(rnd) slr0346(rnc) slr1646(rnc)
            AAE: aq_946(rnc)
            TMA: TM1102
            SCE: YMR239C(RNT1)
            SPO: PAC1(pac1)
            CEL: F26E4.13
MOTIF       PS: PS00517  [DEQ]-[KRQT]-[LM]-E-[FYW]-[LV]-G-D-[SARH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.3
            ExPASy - ENZYME nomenclature database: 3.1.26.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.3
            BRENDA, the Enzyme Database: 3.1.26.3
///
ENTRY       EC 3.1.26.4
NAME        Calf thymus ribonuclease H
            Endoribonuclease H (calf thymus)
            RNase H
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester
SUBSTRATE   RNA
            H2O
PRODUCT     RNA 5'-phosphate
COMMENT     Acts on RNA-DNA hybrids. Similar enzymes are obtained from E.coli,
            chicken embryo, human KB cells, rat liver, Ustilago maydis, human
            leucaemic cells, Saccharomyces cerevisiae (H2), and Tetrahymena
            pyriformis.
GENES       ECO: b0183(rnhB) b0214(rnhA)
            ECE: Z0195(rnhB) Z0239(rnhA)
            ECS: ECs0185 ECs0210
            YPE: YPO1058(rnhB) YPO1081(rnhA)
            HIN: HI0138(rnhA) HI1059(rnhB)
            PMU: PM0107(rnh) PM1998(rnhB)
            XFA: XF1041 XF2158
            VCH: VC0498 VC2234 VC2246
            PAE: PA1815(rnhA) PA3642(rnhB)
            NME: NMB0192 NMB1618
            NMA: NMA0075(rnhB) NMA1817(rnhA)
            HPY: HP0661(rnhA) HP1323(rnhB)
            HPJ: jhp0606 jhp1243
            CJE: Cj0010c(rnhB) Cj1636c(rnhA)
            RPR: RP202(rnhB) RP726(rnhA)
            RCO: RC0264(rnhB) RC1108(rnhA)
            MLO: mll7416 mlr7504
            SME: SMc00018(rnhA1) SMc00867(rnhB) SMc02327(rnhA2)
            CCR: CC0379 CC3365
            BSU: BG12666(rnhB)
            BHA: BH2475(rnh)
            SAU: SA1087(rnhB)
            SAV: SAV1231(rnhB)
            LLA: L0320(rnhB)
            SPY: SPy1162(rnh)
            SPN: SP1156
            SPR: spr1044(rnh)
            CAC: CAC1762(rnh)
            MPU: MYPU_3000(rnhB)
            MTU: Rv2902c(rnhB)
            MTC: MT2970
            MLE: ML1611(rnhB)
            CTR: CT029
            CMU: TC0298
            CPN: CPn0119
            CPA: CP0654
            CPJ: rnhB_1
            BBU: BB0046(rnhB)
            TPA: TP0353
            SYN: slr0080(rnhA) slr1130(rhnB)
            DRA: DR0899 DR1949
            AAE: aq_1955(rnhB)
            TMA: TM0915
            MJA: MJ0135
            MTH: MTH1023
            AFU: AF0621(rnhB)
            HAL: VNG1984G(rnh)
            TAC: Ta1458
            TVO: TVG0142583
            PHO: PH1650
            PAB: PAB0352(rnhB)
            APE: APE0496
            SSO: SSO2384(rnhB)
            STO: ST0519
            SCE: YMR234W(RNH1) YNL072W(RNH35)
            SPO: RNH1(rnh1)
            ATH: At2g25100(F13D4.60)
            CEL: C04F12.9 F59A6.6
            DME: CG13690
            HSA: 10535(RNASEHI) 6040(RNASEH1)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1EKE  1ETC  1F21  1G15  1GOA  1GOB  1GOC  1I39  1I3A  1IO2  
                 1KVA  1KVB  1KVC  1LAV  1LAW  1QHK  1RBR  1RBS  1RBT  1RBU  
                 1RBV  1RCH  1RDA  1RDB  1RDC  1RDD  1RIL  1RNH  2RN2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.4
            ExPASy - ENZYME nomenclature database: 3.1.26.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.4
            BRENDA, the Enzyme Database: 3.1.26.4
            SCOP (Structural Classification of Proteins): 3.1.26.4
///
ENTRY       EC 3.1.26.5
NAME        Ribonuclease P
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
            from tRNA precursor.
SUBSTRATE   RNA
            H2O
PRODUCT     RNA
COMMENT     An RNA-containing enzyme, essential for tRNA processing; generates
            5'-termini of mature tRNA molecules. Similar enzyme: RNase P3.
GENES       ECO: b3704(rnpA)
            ECE: Z5195(rnpA)
            ECS: ECs4639
            YPE: YPO4101(rnpA)
            HIN: HI0999(rnpA)
            PMU: PM1163(rnpA)
            XFA: XF2781
            VCH: VC0006
            PAE: PA5569
            BUC: BU014(rnpA)
            NME: NMB1905
            NMA: NMA0550(rnpA)
            HPY: HP1448(rnpA)
            HPJ: jhp1341
            CJE: Cj0960c(rnpA)
            RPR: RP611(rnpA)
            RCO: RC0937(rnpA)
            MLO: mlr4810
            SME: SMc01720(rnpA)
            CCR: CC0768
            BSU: BG10063(rnpA)
            BHA: BH4065(rnpA)
            SAU: SA2502(rnpA)
            SAV: SAV2696(rnpA)
            LLA: L131443(rnpA)
            SPY: SPy0246(rnpA)
            SPN: SP2042
            SPR: spr1853(rnpA)
            CAC: CAC3738(rnpA)
            MGE: MG465(rnpA)
            MPN: K05_orf118(rnpA)
            MPU: MYPU_1530(rnpA)
            MTU: Rv3923c(rnpA)
            MTC: MT4041
            MLE: ML2712(rnpA)
            CTR: CT784
            CMU: TC0167
            CPN: CPn0934
            CPA: CP0927
            CPJ: rnpA
            BBU: BB0441(rnpA)
            SYN: slr1469(rnpA)
            DRA: DR2151
            TMA: TM1463
            SCE: YML091C(RPM2)
            HSA: 10248(RPP20) 10556(RPP30) 10557(RPP38) 10775(POP4)
                 10799(RPP40) 11102(RPP14) 79229(MGC4179)
MOTIF       PS: PS00648  [LIVMFYSN]-x(2)-A-x(2)-R-[NH]-[KRQL]-[LIVMFSA]-[KRA]-R-
                         x-[LIVMTA]-[KR]
STRUCTURES  PDB: 1A6F  1D6T  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.5
            ExPASy - ENZYME nomenclature database: 3.1.26.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.5
            BRENDA, the Enzyme Database: 3.1.26.5
            SCOP (Structural Classification of Proteins): 3.1.26.5
///
ENTRY       EC 3.1.26.6
NAME        Ribonuclease IV
            Endoribonuclease IV
            Poly(A)-specific ribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of poly(A) to fragments terminated by
            3'-hydroxyl and 5'-phosphate groups.
SUBSTRATE   RNA (poly(A))
            H2O
PRODUCT     3'-Hydroxyloligoribonucleotide
            5'-Phosphooligoribonucleotide
COMMENT     Forms oligonucleotides with an average chain length of 10.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.6
            ExPASy - ENZYME nomenclature database: 3.1.26.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.6
            BRENDA, the Enzyme Database: 3.1.26.6
///
ENTRY       EC 3.1.26.7
NAME        Ribonuclease P4
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of RNA, removing 3'-extranucleotides
            from tRNA precursor.
SUBSTRATE   RNA
            tRNA precursor
            H2O
PRODUCT     3'-Extranucleotides
            tRNA
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.7
            ExPASy - ENZYME nomenclature database: 3.1.26.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.7
            BRENDA, the Enzyme Database: 3.1.26.7
///
ENTRY       EC 3.1.26.8
NAME        Ribonuclease M5
            RNAse M5
            5S Ribosomal maturation nuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides,
            respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.
SUBSTRATE   5S-rRNA precursor
            H2O
PRODUCT     5S-rRNA
            5'-Phosphooligoribonucleotide
COMMENT     Converts the 5S-rRNA precursor from Bacillus subtilis into
            5S-rRNA, with 5'-phosphate and 3'-hydroxyl groups.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.8
            ExPASy - ENZYME nomenclature database: 3.1.26.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.8
            BRENDA, the Enzyme Database: 3.1.26.8
///
ENTRY       EC 3.1.26.9
NAME        Ribonuclease (poly-(U)-specific)
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of poly(U) to fragments terminated by
            3'-hydroxyl and 5'-phosphate groups.
SUBSTRATE   RNA (poly(U))
            H2O
PRODUCT     3'-Hydroxyoligoribonucleotide
            5'-Phosphooligoribonucleotide
COMMENT     Forms oligonucleotides with chain length 6-12.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.9
            ExPASy - ENZYME nomenclature database: 3.1.26.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.9
            BRENDA, the Enzyme Database: 3.1.26.9
///
ENTRY       EC 3.1.26.10
NAME        Ribonuclease IX
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of poly(U) or poly(C) to fragments
            terminated by 3'-hydroxyl and 5'-phosphate groups.
SUBSTRATE   RNA (poly(U))
            RNA (poly(C))
            H2O
PRODUCT     3'-Hydroxyoligoribonucleotide
            5'-Phosphooligoribonucleotide
COMMENT     Acts on poly(U) and poly(C) with a higher affinity for poly(C),
            but does not act on poly(A) or poly(G).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.26.10
            ExPASy - ENZYME nomenclature database: 3.1.26.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.10
            BRENDA, the Enzyme Database: 3.1.26.10
///
ENTRY       EC 3.1.27.1
NAME        Ribonuclease T2
            Ribonuclease II
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Two-stage endonucleolytic cleavage to 3'-phosphomononucleotides
            and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate
            intermediate
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Similar enzymes: Plant RNase; E.coli RNase I; RNase N2;
            Microbial RNase II. Formerly EC 2.7.7.17 and 3.1.4.23.
GENES       ATH: At1g26820(T24P13.23) At2g02990(T17M13.16)
MOTIF       PS: PS00530  [FYWL]-x-[LIVM]-H-G-L-W-P
            PS: PS00531  [LIVMF]-x(2)-[HDGTY]-[EQ]-[FYW]-x-[KR]-H-G-x-C
STRUCTURES  PDB: 1BK7  1BOL  1DIX  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.1
            ExPASy - ENZYME nomenclature database: 3.1.27.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.1
            BRENDA, the Enzyme Database: 3.1.27.1
            SCOP (Structural Classification of Proteins): 3.1.27.1
///
ENTRY       EC 3.1.27.2
NAME        Bacillus subtilis ribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 2',3'-cyclic nucleotides.
SUBSTRATE   RNA
            H2O
PRODUCT     2',3'-Cyclic nucleotide
COMMENT     Similar enzymes: Azotobacter agilis RNase; Proteus mirabilis
            RNase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.2
            ExPASy - ENZYME nomenclature database: 3.1.27.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.2
            BRENDA, the Enzyme Database: 3.1.27.2
///
ENTRY       EC 3.1.27.3
NAME        Ribonuclease T1
            Guanyloribonuclease
            Aspergillus oryzae ribonuclease
            RNase N1 and N2
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Two-stage endonucleolytic cleavage to 3'-phosphomononucleotides
            and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic
            phosphate intermediate
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Similar enzymes: N.crassa RNase N1 and N2; Ustilago sphaerogena
            RNase; Chalaropsis RNase; B.subtilis RNase; Microbial RNase I.
            Formerly EC 2.7.7.26 and 3.1.4.8.
            Hydrolyzes the R(p)-configuration of phosphorothioate isomer of
            oligoribonucleotides containing phosphorothioate-linkage almost
            exclusively. Review: 'Stereochemistry of enzymatic reaction of
            phosphates', P.A.Frey, Tetrahedron 38, 1541 (1982).
STRUCTURES  PDB: 1BVI  1RGG  1RGF  1AY7  1B20  1B21  9RNT  8RNT  7RNT  7GSP  
                 6RNT  6GSP  5RNT  5HOH  5GSP  5BU4  5BIR  4RNT  4HOH  4GSP  
                 4BU4  4BIR  3RNT  3HOH  3GSP  3BU4  3BIR  2RNT  2HOH  2GSP  
                 2BU4  2AAE  2AAD  1YGW  1TRQ  1TRP  1RSN  1RNT  1RN4  1RN1  
                 1RLS  1RHL  1RGL  1RGK  1RGH  1RGE  1GMR  1GMQ  1RGC  1RGA  
                 1RDS  1RCL  1RCK  1LRA  1I8V  1I70  1I3I  1I3F  1I2G  1I2F  
                 1I2E  1I0X  1I0V  1HZ1  1HYF  1GSP  1GMP  1BU4  1B27  1G02  
                 1FZU  1FYS  1FUT  1FUS  1DET  1CH0  1B2M  1BOX  1BIR  1B3S  
                 1B2Z  1B2X  1B2U  1B2S  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.3
            ExPASy - ENZYME nomenclature database: 3.1.27.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.3
            BRENDA, the Enzyme Database: 3.1.27.3
            SCOP (Structural Classification of Proteins): 3.1.27.3
///
ENTRY       EC 3.1.27.4
NAME        Ribonuclease U2
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Two-stage endonucleolytic cleavage to 3'-phosphomononucleotides
            and 3'-phosphooligonucleotides ending in Ap or Gp with
            2',3'-cyclic phosphate intermediate
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Similar enzymes: RNase U3; Pleospora RNase; Trichoderma koningi
            RNase III.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.4
            ExPASy - ENZYME nomenclature database: 3.1.27.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.4
            BRENDA, the Enzyme Database: 3.1.27.4
///
ENTRY       EC 3.1.27.5
NAME        Pancreatic ribonuclease
            RNase
            RNase I
            RNase A
            Pancreatic RNase
            Ribonuclease I
            Endoribonuclease I
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotides and
            3'-phosphooligonucleotides ending in Cp or Up with
            2',3'-cyclic phosphate intermediate
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Similar enzymes: Venom RNase; Thiobacillus thioparus RNase;
            Xenopus laevis RNase; Rhizopus oligosporus RNase; Ribonuclease M.
            Formerly EC 2.7.7.16 and 3.1.4.22.
GENES       MMU: 97919(Rib1)
            HSA: 6035(RNASE1) 6036(RNASE2)
DISEASE     MIM: 131410  Ribonuclease, RNase A family, 2, liver
                         (eosinophil-derived neurotoxin)
            MIM: 180440  Ribonuclease, RNase A family, 1 (pancreatic)
MOTIF       PS: PS00127  C-K-x(2)-N-T-F
STRUCTURES  PDB: 1AAC  1A5P  1A5Q  11BA  11BG  1A2W  1J80  1AFK  1AFL  1AFU  
                 1AQP  1B6V  1BC4  1BEL  1BZQ  1C0B  1C0C  1COB  1CP3  1CPG  
                 1CPH  1CUU  1CV3  1DEF  1DFJ  1DY5  1DZA  1E21  1EOS  1EOW  
                 1F0V  1FEV  1GIG  1HI2  1HI3  1HI4  1HI5  1I07  1J7Z  1RND  
                 1J81  1J82  1L99  1LSQ  1RNM  1RNN  1RNO  1RNQ  1RNU  1RNV  
                 1RNW  1RNX  1RNY  1RNZ  1ROB  1RPF  1RPG  1RPH  1RRA  1RSY  
                 1RUV  1SIA  1SRM  1XPS  1XPT  1ZAY  222L  2AAE  2AAS  2DEF  
                 2KCE  2RLN  2RNS  3RAP  3RSD  3RSK  3RSP  4RSD  4RSK  7RSA  
                 8RSA  9RSA  1RNC  1RCN  1RCA  1RBL  1RBJ  1RBI  1RBH  1RBG  
                 1RBF  1RBE  1RBD  1RBC  1RB3  1RB2  1QHC  1PNL  1LTG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.5
            ExPASy - ENZYME nomenclature database: 3.1.27.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.5
            BRENDA, the Enzyme Database: 3.1.27.5
            SCOP (Structural Classification of Proteins): 3.1.27.5
///
ENTRY       EC 3.1.27.6
NAME        Enterobacter ribonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotides and
            3'-phosphooligonucleotides with 2',3'-cyclic phosphate
            intermediates.
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Preference for cleavage at CpA. Homopolymers of A, U or G
            are not hydrolysed.
GENES       ECO: b0611(RNA)
            ECE: Z0755(rna)
            ECS: ECs0650
MOTIF       PS: PS00530  [FYWL]-x-[LIVM]-H-G-L-W-P
            PS: PS00531  [LIVMF]-x(2)-[HDGTY]-[EQ]-[FYW]-x-[KR]-H-G-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.6
            ExPASy - ENZYME nomenclature database: 3.1.27.6
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.6
            BRENDA, the Enzyme Database: 3.1.27.6
///
ENTRY       EC 3.1.27.7
NAME        Ribonuclease F
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of RNA precursor into two, leaving
            5'-hydroxyl and 3'-phosphate groups.
SUBSTRATE   RNA
            H2O
PRODUCT     5'-Hydroxyoligoribonucleotide
            3'-Phosphooligoribonucleotide
COMMENT     Cleavage takes place between a cytosine and an adenine moiety.
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.7
            ExPASy - ENZYME nomenclature database: 3.1.27.7
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.7
            BRENDA, the Enzyme Database: 3.1.27.7
///
ENTRY       EC 3.1.27.8
NAME        Ribonuclease V
            Endoribonuclease V
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Hydrolysis of poly(A), forming oligoribonucleotides and
            ultimately 3'-AMP.
SUBSTRATE   RNA (poly(A))
            RNA (poly(U))
            H2O
PRODUCT     3'-AMP
            3'-UMP
COMMENT     Also hydrolyses poly(U).
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.8
            ExPASy - ENZYME nomenclature database: 3.1.27.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.8
            BRENDA, the Enzyme Database: 3.1.27.8
///
ENTRY       EC 3.1.27.9
NAME        tRNA-intron endonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and
            2',3'-cyclic phosphate termini, and specifically removing the
            intron.
SUBSTRATE   Pre-tRNA
            H2O
PRODUCT     5'-Hydroxyoligoribonucleotide
            2',3'-Cyclicphosphooligoribonucleotide
            tRNA
COMMENT     The enzyme catalyses the final stage in the maturation of tRNA
            molecules.
GENES       MJA: MJ1424(endA)
            MTH: MTH250
            AFU: AF0900(endA)
            HAL: VNG2210G(endA)
            PHO: PH0295
            PAB: PAB1099(endA)
            APE: APE0685 APE1646
            SSO: SSO0439
            STO: ST0358
            SCE: YAR008W(SEN34) YLR105C(SEN2) YMR059W(SEN15) YPL083C(SEN54)
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.9
            ExPASy - ENZYME nomenclature database: 3.1.27.9
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.9
            BRENDA, the Enzyme Database: 3.1.27.9
///
ENTRY       EC 3.1.27.10
NAME        rRNA endonuclease
            alpha-Sarcin
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Hydrolysis of the phosphodiester linkage between guanosine and
            adenosine residues at one specific position in 28S rRNA from rat
            ribosomes.
SUBSTRATE   28S rRNA
            H2O
PRODUCT     Oligoribonucleotide
COMMENT     Also acts on bacterial rRNA.
STRUCTURES  PDB: 1DE3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.27.10
            ExPASy - ENZYME nomenclature database: 3.1.27.10
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.10
            BRENDA, the Enzyme Database: 3.1.27.10
            SCOP (Structural Classification of Proteins): 3.1.27.10
///
ENTRY       EC 3.1.30.1
NAME        Aspergillus nuclease S1
            Endonuclease S1 (Aspergillus)
            Single-stranded-nucleate endonuclease
            Deoxyribonuclease S1
CLASS       Hydrolases
            Acting on ester bonds
            Endonucleases active with either ribo- or deoxyribonucleic acids
            and producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomononucleotide and
            5'-phosphooligonucleotide end-products
SUBSTRATE   RNA
            DNA
            H2O
PRODUCT     5'-Phosphomononucleotide
            5'-Phosphooligonucleotide
COMMENT     Similar enzymes: N.crassa nuclease; Mung bean nuclease;
            Penicillium citrinum nuclease P1. Preference for single-stranded
            substrate. Formerly EC 3.1.4.21.
STRUCTURES  PDB: 1AK0  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.30.1
            ExPASy - ENZYME nomenclature database: 3.1.30.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.30.1
            BRENDA, the Enzyme Database: 3.1.30.1
            SCOP (Structural Classification of Proteins): 3.1.30.1
///
ENTRY       EC 3.1.30.2
NAME        Serratia marcescens nuclease
            Endonuclease (Serratia marcescens)
CLASS       Hydrolases
            Acting on ester bonds
            Endonucleases active with either ribo- or deoxyribonucleic acids
            and producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomononucleotide and
            5'-phosphooligonucleotide end-products
SUBSTRATE   RNA
            DNA
            H2O
PRODUCT     5'-Phosphomononucleotide
            5'-Phosphooligonucleotide
COMMENT     Hydrolyses double- or single-stranded substrate. Similar enzymes:
            Silkworm nuclease; potato nuclease; Azotobacter nuclease.
            Formerly EC 3.1.4.9.
MOTIF       PS: PS01070  D-R-G-H-[QLIM]-x(3)-[AG]
STRUCTURES  PDB: 1QL0  1G8T  1QAE  1SMN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.30.2
            ExPASy - ENZYME nomenclature database: 3.1.30.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.30.2
            BRENDA, the Enzyme Database: 3.1.30.2
            SCOP (Structural Classification of Proteins): 3.1.30.2
///
ENTRY       EC 3.1.31.1
NAME        Micrococcal nuclease
            Micrococcal endonuclease
CLASS       Hydrolases
            Acting on ester bonds
            Endonucleases active with either ribo- or deoxyribonucleic acids
            and producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotide and
            3'-phosphooligonucleotide end-products
SUBSTRATE   RNA
            H2O
            DNA
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Hydrolyses double- or single-stranded substrate. Similar enzymes:
            Chlamydomonas nuclease; Spleen phosphodiesterase; Spleen
            endonuclease. Formerly EC 3.1.4.7. cf. EC 3.1.16.1.
            (EC 3.1.16.1 Spleen exonuclease)
GENES       CJE: Cj0979c
            BSU: BG13573(yokF)
            SAU: SA0746
            SAV: SAV0801 SAV1309(nuc)
            MPU: MYPU_1390
            AAE: aq_710(nucI)
            MJA: MJ1439
            MTH: MTH494
            PHO: PH1212
            PAB: PAB0704
MOTIF       PS: PS01123  D-G-D-T-[LIVM]-x-[LIVMC]-x(9,10)-R-[LIVM]-x(2)-[LIVM]-
                         D-x-P-E
            PS: PS01284  D-[KR]-Y-[GQ]-R-x-[LV]-[GA]-x-[IV]-[FYW]
STRUCTURES  PDB: 5NUC  2SNM  2NUC  1STY  1SYG  1SYF  1SYE  1SYD  1SYC  2ENB  
                 1SYB  1STH  1STG  1STB  1STA  1SNQ  1SNP  1SNO  1SNM  1SND  
                 1SNC  1NUC  1KDC  1STN  1KDB  1NSN  1JOR  1JOQ  1JOO  1JOK  
                 1EZ8  1EZ6  1EYD  1EYC  1EYA  1EY9  1EY8  1EY7  1EY6  1EY5  
                 1EY4  1EY0  1ENC  1ENA  1AEX  1A3V  1A3U  1A3T  1A2U  1A2T  
                 2SOB  1KDA  3NUC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.1.31.1
            ExPASy - ENZYME nomenclature database: 3.1.31.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.31.1
            BRENDA, the Enzyme Database: 3.1.31.1
            SCOP (Structural Classification of Proteins): 3.1.31.1
///
ENTRY       EC 3.2.1.1
NAME        alpha-Amylase
            Glycogenase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan glucanohydrolase
REACTION    Endohydrolysis of 1,4-alpha-D-glucosidic linkages in
            polysaccharides containing three or more 1,4-alpha-linked
            D-glucose units
SUBSTRATE   Starch
            Glycogen
            H2O
            Polysaccharide
PRODUCT     Oligosaccharide
COMMENT     Acts on starch, glycogen and related polysaccharides and
            oligosaccharides in a random manner; reducing groups are
            liberated in the alpha-configuration.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1927(amyA) b3571(malS)
            ECE: Z3017(amyA) Z4996(malS)
            ECS: ECs2666 ECs4454
            YPE: YPO4080(malS)
            VCH: VCA0250 VCA0860
            BSU: BG10473(amyE)
            LLA: L128692(amyY) L77437(amyL)
            SPN: SP1382
            SPR: spr0247(pulA) spr1239(amy)
            MPU: MYPU_6320(amyC)
            TMA: TM1650 TM1840
            MJA: MJ1611
            PHO: PH0193
            PAB: PAB0118(amyA)
            SSO: SSO0988
            STO: ST0817
            SPO: SPAC23D3.14C(spac23d3.14c) SPAC27E2.01(spac27e2.01)
                 SPAC4A8.01(spac4a8.01) SPCC11E10.09C SPCC63.02C(spcc63.02c)
                 SPCC757.12(spcc757.12)
            DME: CG17876(Amy-d) CG8221(Amyrel)
            MMU: 88019(Amy1) 88020(Amy2)
            HSA: 276(AMY1A) 277(AMY1B) 278(AMY1C) 279(AMY2A) 280(AMY2B)
DISEASE     MIM: 104650  Amylase, pancreatic, alpha-2A
            MIM: 104660  Amylase, pancreatic, alpha-2B
            MIM: 104700  Amylase, salivary, alpha-1A
MOTIF       PS: PS00506  H-x-C-G-G-N-V-G-D
            PS: PS00679  G-x-[SA]-G-E-[LIVM]-R-Y-P-S-Y
            PS: PS01072  [LVFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[FYWPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,6)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
STRUCTURES  PDB: 1VJS  1AMY  1AQH  1AQM  1AVA  1B0I  1B2Y  1BAG  1BG9  1BLI  
                 1BPL  1BSI  1BVN  1C8Q  1CLV  1CPU  1DHK  1E3X  1E3Z  1E40  
                 1E43  1EH9  1EHA  1HNY  1HVX  1HX0  1JAE  1JFH  1JXJ  1JXK  
                 1OSE  1PIF  1PIG  1PPI  1QHP  1SMD  1TMQ  1VIW  7TAA  2AAA  
                 2CPU  2TAA  3CPU  6TAA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.1
            ExPASy - ENZYME nomenclature database: 3.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.1
            BRENDA, the Enzyme Database: 3.2.1.1
            SCOP (Structural Classification of Proteins): 3.2.1.1
///
ENTRY       EC 3.2.1.2
NAME        beta-Amylase
            Saccharogen amylase
            Glycogenase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan maltohydrolase
REACTION    Hydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides
            so as to remove successive maltose units from the non-rducing ends
            of the chains
SUBSTRATE   Polysaccharide
            Starch
            Glycogen
            H2O
PRODUCT     Maltose
COMMENT     Acts on starch, glycogen and related polysaccharides and
            oligosaccharides producing beta-maltose by an inversion.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ATH: At4g15210(dl3650c)
MOTIF       PS: PS00506  H-x-C-G-G-N-V-G-D
            PS: PS00679  G-x-[SA]-G-E-[LIVM]-R-Y-P-S-Y
STRUCTURES  PDB: 1B1Y  5BCA  1B90  1B9Z  1BFN  1BTC  1BYA  1BYB  1BYC  1BYD  
                 1FA2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.2
            ExPASy - ENZYME nomenclature database: 3.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.2
            BRENDA, the Enzyme Database: 3.2.1.2
            SCOP (Structural Classification of Proteins): 3.2.1.2
///
ENTRY       EC 3.2.1.3
NAME        Glucan 1,4-alpha-glucosidase
            Glucoamylase
            Amyloglucosidase
            gamma-Amylase
            Lysosomal alpha-glucosidase
            Acid maltase
            Exo-1,4-alpha-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan glucohydrolase
REACTION    Hydrolysis of terminal 1,4-linked alpha-D-glucose residues
            successively from non-reducing ends of the chains with release
            of beta-D-glucose
SUBSTRATE   Polysaccharide
            Starch
            Glycogen
            H2O
PRODUCT     beta-D-Glucose
COMMENT     Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-
            glucosidic bonds when the next bond in sequence is 1,4, and some
            preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-
            glucosidic bonds in other polysaccharides. This entry covers all
            such enzymes acting on polysaccharides more rapidly than on
            oligosaccharides. EC 3.2.1.20 from mammalian intestine can
            catalyse similar reactions.
            (EC 3.2.1.20 alpha-Glucosidase)
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SSO: SSO0990
            STO: ST0815
            SCE: YDL037C YIL099W(SGA1) YIR019C(MUC1)
            HSA: 2548(GAA) 8972(MGAM)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00129  [GF]-[LIVMF]-W-x-D-M-[NSA]-E
            PS: PS00707  G-[AV]-D-[LIVMTA]-C-G-[FY]-x(3)-[ST]-x(3)-L-C-x-R-W-
                         x(2)-[LV]-[GSA]-[SA]-F-x-P-F-x-R-[DN]
            PS: PS00820  [STN]-[GP]-x(1,2)-[DE]-x-W-E-E-x(2)-[GS]
STRUCTURES  PDB: 1ACZ  1AGM  1AYX  1DOG  1GAH  1GAI  1GLM  1KUL  1KUM  3GLY  
                 1AC0  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.3
            ExPASy - ENZYME nomenclature database: 3.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.3
            BRENDA, the Enzyme Database: 3.2.1.3
            SCOP (Structural Classification of Proteins): 3.2.1.3
///
ENTRY       EC 3.2.1.4
NAME        Cellulase
            Endo-1,4-beta-glucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-(1,3;1,4)-beta-D-Glucan 4-glucanohydrolase
REACTION    Endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose,
            lichenin and cereal beta-D-glucans.
SUBSTRATE   Cellulose
            H2O
            Lichenin
            beta-D-Glucan
PRODUCT     Cellulose
COMMENT     Will also hydrolyse 1,4-linkages in beta-D-glucans also containing
            1,3-linkages.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b3531(yhjM)
            YPE: YPO3998
            BSU: BG10437(bglC)
            CAC: CAC0214 CAC0215
            UUR: UU280(celM)
            SYN: slr0897
            DRA: DR0229
            TMA: TM1048 TM1049 TM1050 TM1524 TM1751 TM1752
            MJA: MJ0555
            MTH: MTH437 MTH977
            AFU: AF1795(celM)
            HAL: VNG1498G(celM)
            PHO: PH1527
            PAB: PAB0437
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00448  D-[LIVMFY]-[DNV]-x-[DNS]-x(2)-[LIVM]-[DN]-[SALM]-x-D-
                         x(3)-[LIVMF]-x-[RKS]-x-[LIVMF]
            PS: PS00561  W-N-[STAGR]-[STDN]-[LIVM]-x(2)-[GST]-x-[GST]-x(2)-
                         [LIVMFT]-[GA]
            PS: PS00562  C-G-G-x(4,7)-G-x(3)-C-x(5)-C-x(3,5)-[NHG]-x-[FYWM]-
                         x(2)-Q-C
            PS: PS00591  [GTA]-x(2)-[LIVN]-x-[IVMF]-[ST]-E-[LIY]-[DN]-[LIVMF]
            PS: PS00592  [STV]-x-[LIVMFY]-[STV]-x(2)-G-x-[NKR]-x(4)-[PLIVM]-H-x-
                         R
            PS: PS00655  V-x-Y-x(2)-P-x-R-D-C-[GSAF]-x(2)-[GSA](2)-x-G
            PS: PS00656  [LIVMYA]-[LIVA]-[LIVT]-[LIV]-E-P-D-[SAL]-[LI]-[PSAG]
            PS: PS00659  [LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-x-N-E-[PV]-
                         [RHDNSTLIVFY]
            PS: PS00698  [FYW]-x-D-x(4)-[FYW]-x(3)-E-x-[STA]-x(3)-N-[STA]
            PS: PS00812  A-[ST]-D-[AG]-D-x(2)-[IM]-A-x-[SA]-[LIVM]-[LIVMG]-x-A-
                         x(3)-[FW]
            PS: PS01072  [LVFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[FYWPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,6)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
            PS: PS01140  [STA]-T-R-Y-[FYW]-D-x(5)-[CA]
            PS: PS01159  W-x(9,11)-[VFY]-[FYW]-x(6,7)-[GSTNE]-[GSTQCR]-[FYW]-
                         x(2)-P
STRUCTURES  PDB: 6A3H  2NLR  2ENG  2A3H  2A39  1ULP  1ULO  1TML  1QI2  1TF4  
                 1QHZ  1OVW  1NLR  1JS4  1HD5  7A3H  1QI0  1G01  1FCE  1FBW  
                 1FBO  1H8V  1F9O  1F9D  1EGZ  1EG1  1EDG  1ECE  1E5J  1DYS  
                 1DYM  1DAV  1DAQ  1CX1  1CLC  1CEO  1CEN  1CEM  1CEC  1AIW  
                 1A3H  1A39  3A3H  3ENG  3OVW  3TF4  4A3H  4ENG  4OVW  4TF4  
                 5A3H  1G0C  8A3H  1FAE  2OVW  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.4
            ExPASy - ENZYME nomenclature database: 3.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.4
            BRENDA, the Enzyme Database: 3.2.1.4
            SCOP (Structural Classification of Proteins): 3.2.1.4
///
ENTRY       EC 3.2.1.5
NAME        Deleted entry
            Licheninase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.5
            ExPASy - ENZYME nomenclature database: 3.2.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.5
///
ENTRY       EC 3.2.1.6
NAME        Endo-1,3(4)-beta-glucanase
            Endo-1,3-beta-glucanase
            Laminarinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-(1,3;1,4)-beta-D-Glucan 3(4)-glucanohydrolase
REACTION    Endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the
            glucose residue whose reducing group is involved in the linkage
            to be hydrolysed is itself substituted at C-3
SUBSTRATE   beta-D-Glucan
            H2O
            Laminarin
            Lichenin
            Cereal D-glucan
PRODUCT     beta-D-Glucan
COMMENT     Substrate include laminarin, lichenin and cereal D-glucans;
            different from EC 3.2.1.39.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.6
            ExPASy - ENZYME nomenclature database: 3.2.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.6
            BRENDA, the Enzyme Database: 3.2.1.6
///
ENTRY       EC 3.2.1.7
NAME        Inulinase
            Inulase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     2,1-beta-D-Fructan fructanohydrolase
REACTION    Endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin
SUBSTRATE   Inulin
            H2O
PRODUCT     Inulin
MOTIF       PS: PS00609  H-x(2)-P-x(4)-[LIVM]-N-D-P-N-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.7
            ExPASy - ENZYME nomenclature database: 3.2.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.7
            BRENDA, the Enzyme Database: 3.2.1.7
///
ENTRY       EC 3.2.1.8
NAME        Endo-1,4-beta-xylanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-beta-D-Xylan xylanohydrolase
REACTION    Endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans
SUBSTRATE   Xylan
            H2O
PRODUCT     Xylan
GENES       BSU: BG10808(xynA)
            BHA: BH0899 BH0900 BH2120
            TMA: TM0061 TM0070
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00448  D-[LIVMFY]-[DNV]-x-[DNS]-x(2)-[LIVM]-[DN]-[SALM]-x-D-
                         x(3)-[LIVMF]-x-[RKS]-x-[LIVMF]
            PS: PS00561  W-N-[STAGR]-[STDN]-[LIVM]-x(2)-[GST]-x-[GST]-x(2)-
                         [LIVMFT]-[GA]
            PS: PS00591  [GTA]-x(2)-[LIVN]-x-[IVMF]-[ST]-E-[LIY]-[DN]-[LIVMF]
            PS: PS00659  [LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-x-N-E-[PV]-
                         [RHDNSTLIVFY]
            PS: PS00776  [PSA]-[LQ]-x-E-Y-Y-[LIVM](2)-[DE]-x-[FYWHN]
            PS: PS00777  [LIVMF]-x(2)-E-[AG]-[YWG]-[QRFGS]-[SG]-[STAN]-G-x-[SAF]
            PS: PS01034  E-[LIV]-D-[LIVF]-x(0,1)-E-x(2)-[GQ]-[KRNF]-x-[PSTA]
            PS: PS01072  [LVFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[FYWPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,6)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
STRUCTURES  PDB: 2XBD  1XYF  1XYN  1XYO  1XYP  1XYS  1XYZ  1YNA  2BVV  1HEH  
                 1I8A  1FXM  1F5J  1EXP  1ENX  1E8R  1E5N  1E5C  1E5B  1E0X  
                 1E0W  1E0V  1CLX  1C5I  1XND  1XNC  1XNB  1XBD  1XAS  1UKR  
                 1TUX  1TIX  1TAX  1REF  1REE  1RED  1QLD  1QH7  1QH6  1PVX  
                 1I8U  1C5H  1I82  1HV1  1HV0  1HEJ  1AXK  1B30  1B31  1B3V  
                 1B3W  1B3X  1B3Y  1B3Z  1BCX  1BG4  1BK1  1BVV  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.8
            ExPASy - ENZYME nomenclature database: 3.2.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.8
            BRENDA, the Enzyme Database: 3.2.1.8
            SCOP (Structural Classification of Proteins): 3.2.1.8
///
ENTRY       EC 3.2.1.9
NAME        Deleted entry
            Amylopectin-1,6-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.9
            ExPASy - ENZYME nomenclature database: 3.2.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.9
///
ENTRY       EC 3.2.1.10
NAME        Oligo-1,6-glucosidase
            Limit dextrinase
            Isomaltase
            Sucrase-isomaltase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Dextrin 6-alpha-D-glucanohydrolase
REACTION    Hydrolysis of 1,6-alpha-D-glucosidic linkages in isomaltose and
            dextrins produced from starch and glycogen by alpha-amylase.
SUBSTRATE   Isomaltose
            Dextrin
            Palatinose
            H2O
PRODUCT     D-Glucose
            Dextrin
COMMENT     Also hydrolyses palatinose. The enzyme from intestinal mucosa is
            a single polypeptide chain also catalysing the reaction of
            EC 3.2.1.48 (Sucrose alpha-glucosidase).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       BSU: BG12421(malL) BG12762(ycdG)
            BHA: BH2903
            LLA: L128693(dexA)
            SPY: SPy1973(dexB)
            SPN: SP0342
            MPU: MYPU_1030 MYPU_6330
            HSA: 6476
MOTIF       PS: PS00025  [KR]-x(2)-C-x-[FYPST]-x(3,4)-[ST]-x(3)-C-x(4)-C-C-
                         [FYWH]
            PS: PS00129  [GF]-[LIVMF]-W-x-D-M-[NSA]-E
            PS: PS00707  G-[AV]-D-[LIVMTA]-C-G-[FY]-x(3)-[ST]-x(3)-L-C-x-R-W-
                         x(2)-[LV]-[GSA]-[SA]-F-x-P-F-x-R-[DN]
STRUCTURES  PDB: 1UOK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.10
            ExPASy - ENZYME nomenclature database: 3.2.1.10
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.10
            BRENDA, the Enzyme Database: 3.2.1.10
            SCOP (Structural Classification of Proteins): 3.2.1.10
///
ENTRY       EC 3.2.1.11
NAME        Dextranase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-alpha-D-Glucan 6-glucanohydrolase
REACTION    Endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran
SUBSTRATE   Dextran
            H2O
PRODUCT     Dextran
GENES       SPR: spr1698(dexS)
MOTIF       PS: PS00343  L-P-x-T-G-[STGAVDE]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.11
            ExPASy - ENZYME nomenclature database: 3.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.11
            BRENDA, the Enzyme Database: 3.2.1.11
///
ENTRY       EC 3.2.1.12
NAME        Deleted entry
            Cycloheptaglucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.2.1.54.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.12
            ExPASy - ENZYME nomenclature database: 3.2.1.12
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.12
///
ENTRY       EC 3.2.1.13
NAME        Deleted entry
            Cyclohexaglucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.2.1.54.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.13
            ExPASy - ENZYME nomenclature database: 3.2.1.13
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.13
///
ENTRY       EC 3.2.1.14
NAME        Chitinase
            Chitodextrinase
            1,4-beta-Poly-N-acetylglucosaminidase
            Poly-beta-glucosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(1,4-(N-acetyl-beta-D-glucosaminide)) glycanohydrolase
REACTION    Random hydrolysis of N-acetyl-beta-D-glucosaminide
            1,4-beta-linkages in chitin and chitodextrins.
SUBSTRATE   Chitin
            Chitodextrin
            H2O
PRODUCT     N-Acetyl-D-glucosaminide
            N-Acetyl-D-glucosamine
INHIBITOR   Allosamidine
COMMENT     Some chitinases also display the activity defined in EC 3.2.1.17.
            (EC 3.2.1.17: Lysozyme). Allosamidine (Agric.Biol.Sci. 1987, 51,
            3251-3259; 1988, 52, 1615-1617).
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       VCH: VCA0027
            BHA: BH0916
            SCE: YLR286C(CTS1)
            ATH: At4g01700(T15B16.5)
            CEL: C04F6.3
            DME: CG17682(Cht1) CG18140(Cht3) CG1869 CG2054(Cht2) CG5210(Chit)
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00026  C-x(4,5)-C-C-S-x(2)-G-x-C-G-x(4)-[FYW]-C
            PS: PS00561  W-N-[STAGR]-[STDN]-[LIVM]-x(2)-[GST]-x-[GST]-x(2)-
                         [LIVMFT]-[GA]
            PS: PS00773  C-x(4,5)-F-Y-[ST]-x(3)-[FY]-[LIVMF]-x-A-x(3)-[YF]-x(2)-
                         F-[GSA]
            PS: PS00774  [LIVM]-[GSA]-F-x-[STAG](2)-[LIVMFY]-W-[FY]-W-[LIVM]
            PS: PS01095  [LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E
STRUCTURES  PDB: 2HVM  1CNS  1CTN  1D2K  1DXJ  1E6Z  1ED7  1EDQ  1EHN  1EIB  
                 1FFR  1HVQ  1LLO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.14
            ExPASy - ENZYME nomenclature database: 3.2.1.14
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.14
            BRENDA, the Enzyme Database: 3.2.1.14
            SCOP (Structural Classification of Proteins): 3.2.1.14
///
ENTRY       EC 3.2.1.15
NAME        Polygalacturonase
            Pectin depolymerase
            Pectinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(1,4-alpha-D-galacturonide) glycanohydrolase
REACTION    Random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in
            pectate and other galacturonans
SUBSTRATE   Pectate
            Galacturonan
            H2O
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00500  Starch and sucrose metabolism
GENES       SCE: YJR153W(PGU1)
MOTIF       PS: PS00502  [GSDENKRH]-x(2)-[VMFC]-x(2)-[GS]-H-G-[LIVMAG]-x(1,2)-
                         [LIVM]-G-S
STRUCTURES  PDB: 1IA5  1CZF  1BHE  1IB4  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.15
            ExPASy - ENZYME nomenclature database: 3.2.1.15
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.15
            BRENDA, the Enzyme Database: 3.2.1.15
            SCOP (Structural Classification of Proteins): 3.2.1.15
///
ENTRY       EC 3.2.1.16
NAME        Deleted entry
            Alginase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.16
            ExPASy - ENZYME nomenclature database: 3.2.1.16
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.16
///
ENTRY       EC 3.2.1.17
NAME        Lysozyme
            Muramidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Peptidoglycan N-acetylmuramoylhydrolase
REACTION    Hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and
            N-acetyl-D-glucosamine residues in a peptidoglycan and between
            N-acetyl-D-glucosamine residues in chitodextrins
SUBSTRATE   Peptidoglycan(N-acetyl-D-glucosamine)
            Chitodextrin
PRODUCT     Peptidoglycan
            Chitodextrin
            N-Acetyl-D-glucosamine
COMMENT     (cf. also EC 3.2.1.14 Chitinase)
GENES       ECO: b0555(ybcS) b1554
            YPE: YPO2098
            SPR: spr1431(lytC)
            CAC: CAC0554(lyc)
            DME: CG1165(LysS) CG1179(LysB) CG1180(LysE) CG7798 CG9111(LysC)
                 CG9116(LysP) CG9118(LysD) CG9120(LysX)
            HSA: 4069(LYZ)
DISEASE     MIM: 153450  Lysozyme
MOTIF       PS: PS00128  C-x(3)-C-x(2)-[LMF]-x(3)-[DEN]-[LI]-x(5)-C
            PS: PS00773  C-x(4,5)-F-Y-[ST]-x(3)-[FY]-[LIVMF]-x-A-x(3)-[YF]-x(2)-
                         F-[GSA]
            PS: PS00774  [LIVM]-[GSA]-F-x-[STAG](2)-[LIVMFY]-W-[FY]-W-[LIVM]
            PS: PS00953  D-[LIVM]-x(3)-[NQ]-[PG]-x(9,10)-G-x(4)-[LIVMFY](2)-K-x-
                         [ST]-E-[GS]-x(2)-Y-x-[DN]
            PS: PS01095  [LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E
STRUCTURES  PDB: 1C62  1C63  1C64  1C65  1C66  1C67  1C68  1C69  1C6B  1C6C  
                 1C6D  1C6E  1C6F  1C6G  1C6H  1C6A  1C6J  1C6I  1C6L  1C6M  
                 1C6N  1C6P  1C6Q  1C6T  1C7P  1CJ6  1CJ7  1CJ8  1CJ9  1CKC  
                 1CKD  1CKF  1CKG  1C6K  1CTW  1CU0  1CKH  1CU3  1CU5  1CU6  
                 1CUP  1CUQ  1CV0  1CV1  1CV3  1CV4  1CV5  1CV6  1CVK  1CX6  
                 1CX7  1D2W  1D2Y  1D3F  1D3J  1D3M  1D3N  1D6P  1D6Q  1D9U  
                 1D9W  1DI3  1DI4  1DI5  1DKJ  1DKK  1DPW  1DPX  1CU2  1DYA  
                 1DYB  1DYC  1DYD  1DYE  1DYF  1DQJ  1DZB  1E8L  1EL1  1EPY  
                 1EQ4  1EQ5  1EQE  1F0W  1F10  1FBI  1FDL  1FLQ  1FLU  1FLW  
                 1FLY  1FN5  1G06  1G07  1G0G  1G0J  1G0K  1G0L  1G0M  1G0P  
                 1G0Q  1G1V  1G1W  1G7H  1G7I  1G7J  1G7L  1G7M  1GAY  1GAZ  
                 1GB0  1GB2  1GB3  1GB5  1GB6  1GB7  1GB8  1GB9  1GBO  1GBS  
                 1GBW  1GBX  1GBY  1GBZ  1GD6  1GDW  1GDX  1GE0  1GE1  1GE2  
                 1GE3  1GE4  1GEV  1GEZ  1GF0  1GF3  1GF4  1GF5  1DYG  1GF7  
                 1GF8  1GF9  1GFA  1GFE  1GFG  1GFH  1GFJ  1GFK  1GFR  1GFT  
                 1GFU  1GFV  1GHL  1GF6  1HEL  1HEM  1HEN  1HEO  1HEP  1HEQ  
                 1HER  1HEW  1HF4  1HHL  1HNL  1HSW  1HSX  1HVQ  1I22  1I6S  
                 1IC4  1IC5  1IC7  1IEE  1INU  1IO5  1IOQ  1IOR  1IOS  1IR7  
                 1IR8  1IR9  1JA2  1JA4  1JA6  1JA7  1JEF  1JFX  1JKA  1JKB  
                 1JKC  1JKD  1JPO  1JSE  1JSF  1JUG  1JWR  1KIP  1KIQ  1KIR  
                 1KXW  1KXX  1KXY  1L00  1L01  1L02  1L03  1L04  1L05  1L06  
                 1L07  1L08  1L09  1L10  1L11  1L12  1L13  1L14  1L15  1L16  
                 1L17  1L18  1L19  1L20  1L21  1L22  1L23  1L24  1L25  1L26  
                 1L27  1L28  1L29  1L30  1L31  1L32  1L33  1L34  1L35  1L36  
                 1L37  1L38  1L39  1L40  1L41  1L42  1L43  1L44  1L45  1L46  
                 1L47  1L48  1L49  1L50  1L51  1L52  1L53  1L54  1L55  1L56  
                 1L57  1L58  1L59  1L60  1L61  1L62  1L63  1L64  1L65  1L66  
                 1L67  1L68  1L69  1L70  1L71  1L72  1L73  1C46  1H6M  1L76  
                 1L77  1L79  1L80  1L81  1L82  1L83  1L84  1L85  1L86  1L87  
                 1L88  1L89  1L90  1L91  1L92  1L93  1L94  1L95  1L96  1L97  
                 1L98  1L99  1LAA  1LCN  171L  1LHI  1LHJ  1LHK  1LHL  1LHM  
                 1LKR  1LKS  1LLO  1LMA  1LMC  1LMN  1LMO  1LMP  1LMQ  1LMT  
                 1LOZ  1LPI  1LSA  1LSB  1LSC  1LSD  1LSE  1LSF  1LSM  1LSN  
                 1LSP  1LSY  1LSZ  1LYO  1LYS  1LYY  1LYZ  1LZ1  1LZ3  1LZ4  
                 1LZ5  1LZ6  1LZ8  1LZ9  1LZA  1LZB  1LZC  1LZD  1LZE  1LZG  
                 1LZH  1LZN  1LZR  1LZS  1LZT  1LZY  1MEL  1MII  1NHB  1OUA  
                 1OUB  1OUC  1OUD  1OUE  1OUF  1OUG  1OUH  1OUI  1OUJ  1C45  
                 1QQY  1QS5  1QS9  1QSB  1QSQ  1QT3  1QT4  1QT5  1QT6  1QT7  
                 1QT8  1QTB  1QTC  1QTD  1QTH  1QTK  1QTV  1QTZ  1QUD  1QUG  
                 1QUH  1QUO  1RCM  1RE2  1REM  1REX  1REY  1REZ  1RFP  1TAY  
                 1TBY  1TCY  1TDY  1TEW  1TLA  1UCO  1UIA  1UIB  1UIC  1UID  
                 1UIE  1UIF  1UIG  1UIH  1WQM  1WQN  1WQO  1WQP  1WQQ  1WQR  
                 1XEI  1XEJ  1XEK  1YAM  1YAN  1YAO  1YAP  1YAQ  200L  201L  
                 205L  206L  207L  208L  209L  210L  211L  212L  213L  214L  
                 215L  216L  217L  218L  219L  220L  221L  222L  223L  224L  
                 225L  226L  227L  228L  229L  230L  231L  232L  233L  234L  
                 235L  236L  237L  238L  239L  240L  241L  242L  243L  244L  
                 245L  246L  247L  248L  249L  250L  251L  252L  253L  254L  
                 255L  256L  257L  258L  259L  260L  261L  262L  2BQA  2BQB  
                 2BQC  2BQD  2BQE  2BQF  2BQG  2BQH  2BQI  2BQJ  2BQK  2BQL  
                 2BQM  2BQN  2BQO  2HEA  2HEB  2HEC  2HED  2HEE  2HEF  2HFM  
                 2HVM  2IHL  2L78  2LHM  2LYM  2LYO  2LYZ  2LZ2  2LZH  2LZM  
                 2LZT  2MEA  2MEB  2MEC  2MED  2MEE  2MEF  2MEG  2MEH  2MEI  
                 3HFL  3HFM  3LHM  3LYM  3LYO  3LYT  3LYZ  3LZ2  3LZM  3LZT  
                 4LYM  4LYO  4LYT  4LYZ  4LZM  4LZT  5LYM  5LYT  5LYZ  5LZM  
                 6LYT  6LYZ  6LZM  7LYZ  7LZM  8LYZ  9LYZ  1C43  1C10  1BWJ  
                 1BWI  1BWH  1BVX  1BVK  1BHZ  1BGI  1BB7  1BB6  1BB5  1BB4  
                 1BB3  1B7R  1B7Q  1B7P  1B7O  1B7N  1B7M  1B7L  1B6I  1B5Z  
                 1B5Y  1B5X  1B5W  1B5V  1B5U  1B2K  1B0D  1AZF  1AT6  1AT5  
                 1AKI  1A2Y  199L  198L  197L  196L  195L  192L  191L  190L  
                 189L  188L  187L  186L  185L  184L  183L  182L  181L  180L  
                 179L  178L  177L  176L  175L  174L  173L  1L74  1C61  1C60  
                 1L75  172L  1QIO  113L  112L  127L  143L  144L  145L  146L  
                 147L  170L  169L  168L  167L  166L  165L  164L  163L  162L  
                 161L  160L  1LHH  107L  108L  109L  110L  111L  114L  115L  
                 118L  119L  120L  122L  123L  125L  126L  128L  153L  129L  
                 130L  131L  132L  133L  134L  159L  158L  157L  156L  155L  
                 154L  152L  151L  150L  149L  135L  137L  138L  139L  140L  
                 141L  142L  148L  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.17
            ExPASy - ENZYME nomenclature database: 3.2.1.17
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.17
            BRENDA, the Enzyme Database: 3.2.1.17
            SCOP (Structural Classification of Proteins): 3.2.1.17
///
ENTRY       EC 3.2.1.18
NAME        Exo-alpha-sialidase
            Neuraminidase
            Sialidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Acylneuraminyl hydrolase
REACTION    Hydrolysis of alpha-2,3-, alpha-2,6- and alpha-2,8- glycosidic
            linkages (at a decreasing rate, respectively) of terminal sialic
            residues in oligosaccharides, glycoproteins, glycolipids,
            colominic acid and synthetic substrates
SUBSTRATE   Oligosaccharide(non-reducing N- or O-acylneuraminyl residue)
            Glycoprotein(non-reducing N- or O-acylneuraminyl residue)
            Glycolipid(non-reducing N- or O-acylneuraminyl residue)
            Colominic acid(non-reducing N- or O-acylneuraminyl residue)
            H2O
PRODUCT     Galactose
            N-Acetylhexosamine
INHIBITOR   2-Deoxy-2,3-dehydro-N-acetylneuraminic acid
COMMENT     The enzyme does not act on 4-O-acetylated sialic acids. An
            endo-alpha-sialidase activity is listed as EC 3.2.1.129. See also
            EC 3.2.1.138.
            Inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This
            structure were determined at 2.2 A resolution (Proc.Natl.Acad.
            Sci.USA 90, 9852-56, (1993)).
PATHWAY     PATH: MAP00511  Glycoprotein degradation
            PATH: MAP00600  Sphingoglycolipid metabolism
GENES       SPN: SP1687
            SPR: spr1531(nanB) spr1536(nanA)
            HSA: 4758(NEU1)
DISEASE     MIM: 256550  Neuraminidase 1 (lysosomal sialidase; sialidase 1)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
STRUCTURES  PDB: 3SIL  7NN9  6NN9  5NN9  4SLI  4NN9  3SLI  1A14  1F8C  1F8D  
                 1F8E  1INF  1ING  1INH  1INV  1INW  1INX  1INY  1IVB  1IVC  
                 1IVD  1IVE  1IVF  1IVG  1KIT  1MWE  1NCA  1NCB  1NCC  1NCD  
                 3NN9  1NMA  1NMB  1NMC  1NN2  1NNA  1NNB  2SLI  2SIM  2SIL  
                 2QWK  2QWJ  2QWI  2QWH  2QWG  2QWF  2QWE  2QWD  2QWC  2QWB  
                 2QWA  2BAT  1SLL  1SLI  1NSD  1NNC  1A4G  1A4Q  1B9S  1B9T  
                 1B9V  1BJI  1DIL  1DIM  1E8T  1NSC  1E8U  1E8V  1EUR  1EUS  
                 1EUT  1EUU  1F8B  1NSB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.18
            ExPASy - ENZYME nomenclature database: 3.2.1.18
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.18
            BRENDA, the Enzyme Database: 3.2.1.18
            SCOP (Structural Classification of Proteins): 3.2.1.18
///
ENTRY       EC 3.2.1.19
NAME        Deleted entry
            Heparinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.19
            ExPASy - ENZYME nomenclature database: 3.2.1.19
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.19
///
ENTRY       EC 3.2.1.20
NAME        alpha-Glucosidase
            Maltase
            Glucoinvertase
            Glucosidosucrase
            Maltase-glucoamylase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-D-Glucoside glucohydrolase
REACTION    Hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose
            residues with release of alpha-D-glucose
SUBSTRATE   Maltose
            H2O
PRODUCT     alpha-D-Glucose
INHIBITOR   Castanospermine
COMMENT     This single entry covers a group of enzymes whose specificity is
            directed mainly towards the exohydrolysis of 1,4-alpha-glucosidic
            linkages, and that hydrolyse oligosaccharides rapidly, relative
            to polysaccharides, which are hydrolysed relatively slowly, or
            not at all.  The intestinal enzyme also hydrolyses poly-
            saccharides, catalysing the reactions of EC 3.2.1.3, and, more
            slowly, hydrolyses 1,6-alpha-D-glucose links.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b0403(malZ)
            ECE: Z0501(malZ)
            ECS: ECs0453
            YPE: YPO3200(malZ)
            MLO: mll5109 mlr7593
            SME: SMc03064(aglA)
            CCR: CC2285
            MTU: Rv0126
            MTC: MT0134
            TMA: TM0434 TM0752 TM1068 TM1834
            SSO: SSO3051(malA)
            SCE: YBR299W(MAL32) YGR287C(YGR287C) YGR292W(MAL12)
                 YIL172C(YIL172C) YJL216C YJL221C(FSP2)
            SPO: SPBC1683.07(spbc1683.07)
            DME: CG11669 CG14934 CG14935 CG8690 CG8693 CG8694(LvpD)
                 CG8695(LvpL) CG8696(LvpH)
            HSA: 2594(GANAB) 2595(GANC) 8972(MGAM)
DISEASE     MIM: 154360  Maltase-glucoamylase
            MIM: 232300  Glucosidase, acid alpha-
MOTIF       PS: PS00025  [KR]-x(2)-C-x-[FYPST]-x(3,4)-[ST]-x(3)-C-x(4)-C-C-
                         [FYWH]
            PS: PS00129  [GF]-[LIVMF]-W-x-D-M-[NSA]-E
            PS: PS00707  G-[AV]-D-[LIVMTA]-C-G-[FY]-x(3)-[ST]-x(3)-L-C-x-R-W-
                         x(2)-[LV]-[GSA]-[SA]-F-x-P-F-x-R-[DN]
            PS: PS01324  P-x-[SA]-x-[LIVMFY](2)-[QN]-x(2)-N-P-x(4)-[TA]-x(9,10)-
                         [KRD]-x-[LIV]-[GN]-x-C
STRUCTURES  PDB: 1VAD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.20
            ExPASy - ENZYME nomenclature database: 3.2.1.20
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.20
            BRENDA, the Enzyme Database: 3.2.1.20
            SCOP (Structural Classification of Proteins): 3.2.1.20
///
ENTRY       EC 3.2.1.21
NAME        beta-Glucosidase
            Gentiobiase
            Cellobiase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Glucoside glucohydrolase
REACTION    Hydrolysis of terminal, non-reducing beta-D-glucose residues with
            release of beta-D-glucose.
SUBSTRATE   beta-D-Glucoside
            beta-D-Galactoside
            alpha-L-Arabinoside
            beta-D-Xyloside
            H2O
            beta-D-Fucoside
PRODUCT     beta-D-Glucose
COMMENT     Wide specificity for beta-D-glucosides. Some examples also
            hydrolyse one or more of the following: beta-D-galactosides,
            alpha-L-arabinosides, beta-D-xylosides, beta-D-fucoside.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       ECO: b2132(bglX)
            ECE: Z3381(bglX)
            ECS: ECs3019
            YPE: YPO0616 YPO2803(bglB)
            XFA: XF0439
            PAE: PA1726(bglX)
            RCO: RC1086
            SME: SMc03160
            CCR: CC1105 CC1756 CC2136
            BSU: BG10935(bglH) BG11181(yckE) BG12193(ydhP)
            BHA: BH0596(gblH) BH1923(bglA) BH3918
            LLA: L179659(bglS) L32812(yidC) L89194(bglH)
            SPY: SPy1328(bglA.2)
            SPN: SP0265
            SPR: spr0244(bglA) spr1833(bgl2)
            CAC: CAC0385 CAC1084 CAC1405(bglA)
            MTU: Rv0186 Rv0237(lpqI)
            MTC: MT0195 MT0251
            MLE: ML2569
            BBU: BB0620
            SYN: sll1538(bgl)
            TMA: TM0025 TM0076
            SSO: SSO3032
            SPO: SPBC1683.04(spbc1683.04)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
            PS: PS00775  [LIVM](2)-[KR]-x-[EQK]-x(4)-G-[LIVMFT]-[LIVT]-[LIVMF]-
                         [ST]-D-x(2)-[SGADNI]
STRUCTURES  PDB: 1BGA  1BGG  1CBG  1E1E  1E1F  1E4I  1E4L  1E4N  1E55  1E56  
                 1QOX  1TR1  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.21
            ExPASy - ENZYME nomenclature database: 3.2.1.21
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.21
            BRENDA, the Enzyme Database: 3.2.1.21
            SCOP (Structural Classification of Proteins): 3.2.1.21
///
ENTRY       EC 3.2.1.22
NAME        alpha-Galactosidase
            Melibiase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-D-Galactoside galactohydrolase
REACTION    Hydrolysis of terminal, non-reducing alpha-D-galactose residues
            in alpha-D-galactosides, including galactose oligosaccharides,
            galactomannans and galactolipids
SUBSTRATE   Galactose oligosaccharide
            Galactomannan
            Galactolipid
            alpha-D-Fucoside
            H2O
PRODUCT     alpha-D-Galactose
COMMENT     Also hydrolyses alpha-D-fucosides.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
GENES       ECO: b4119(melA)
            ECE: Z5721(melA)
            ECS: ECs5101
            YPE: YPO1581(rafA)
            MLO: mlr6443 mlr6450
            SME: SMb21643(agaL2) SMb21648(agaL1)
            BSU: BG12615(melA)
            BHA: BH2223 BH2228(melA)
            SPN: SP1898
            SPR: spr1713(aga)
            TMA: TM1192
            SCE: YBR184W(YBR184W)
            MMU: 87962(Ags)
            HSA: 2717(GLA)
DISEASE     MIM: 301500  Galactosidase, alpha
MOTIF       PS: PS00512  G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-D-x-W-x(3,4)-R-
                         [DNSF]
            PS: PS01324  P-x-[SA]-x-[LIVMFY](2)-[QN]-x(2)-N-P-x(4)-[TA]-x(9,10)-
                         [KRD]-x-[LIV]-[GN]-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.22
            ExPASy - ENZYME nomenclature database: 3.2.1.22
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.22
            BRENDA, the Enzyme Database: 3.2.1.22
///
ENTRY       EC 3.2.1.23
NAME        beta-Galactosidase
            Lactase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Galactoside galactohydrolase
REACTION    Hydrolysis of terminal non-reducing beta-D-galactose residues in
            beta-D-galactosides
SUBSTRATE   beta-D-Galactoside
            alpha-D-Arabinoside
            beta-D-Fucoside
            beta-D-Glucoside
            H2O
PRODUCT     beta-D-Galactose
COMMENT     Some enzymes in this group hydrolyse alpha-L-arabinosides; some
            animal enzymes also hydrolyse beta-D-fucosides and beta-D-
            glucosides. (cf. EC 3.2.1.108 Lactase).
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00511  Glycoprotein degradation
            PATH: MAP00531  Glycosaminoglycan degradation
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
GENES       ECO: b0344(lacZ) b3076(ebgA) b3077(ebgC)
            ECE: Z0440(lacZ) Z4429(ebgA) Z4430(ebgC)
            ECS: ECs0397 ECs3958
            YPE: YPO0852(bgaB) YPO1654(lacZ)
            XFA: XF0840
            SME: SMb20966(lacZ2) SMb21655(lacZ1)
            BSU: BG12439(lacA) BG12860(yesZ)
            BHA: BH2022(lacA) BH2723 BH3701
            LLA: L0025(lacZ)
            SPN: SP0060 SP0648
            SPR: spr0059(bgaC) spr0565(bgaA)
            TMA: TM0310 TM1193 TM1195
            PAB: PAB1349 PAB2376(bgal)
            SSO: SSO3019(lacS)
            STO: ST0773
            CEL: T19B10.3
            DME: CG3132
            MMU: 88151(Bgl)
            HSA: 2720(GLB1)
DISEASE     MIM: 230500  Galactosidase, beta-1
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00608  [DENQLF]-[KRVW]-N-[HRY]-[STAPV]-[SAC]-[LIVMFS](3)-W-
                         [GS]-x(2,3)-N-E
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
            PS: PS00719  N-x-[LIVMFYWD]-R-[STACN](2)-H-Y-P-x(4)-[LIVMFYWS](2)-
                         x(3)-[DN]-x(2)-G-[LIVMFYW](4)
            PS: PS01182  G-G-P-[LIVM](2)-x(2)-Q-x-E-N-E-[FY]
STRUCTURES  PDB: 1BGL  1BGM  1DP0  1F49  1F4A  1F4H  1GHO  1GOW  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.23
            ExPASy - ENZYME nomenclature database: 3.2.1.23
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.23
            BRENDA, the Enzyme Database: 3.2.1.23
            SCOP (Structural Classification of Proteins): 3.2.1.23
///
ENTRY       EC 3.2.1.24
NAME        alpha-Mannosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-D-Mannoside mannohydrolase
REACTION    Hydrolysis of terminal, non-reducing alpha-D-mannose residues in
            alpha-D-mannosides
SUBSTRATE   alpha-D-Mannoside
            H2O
            alpha-D-Lyxoside
            Heptopyranosides
PRODUCT     alpha-D-Mannose
            alpha-D-Lyxose
COMMENT     Also hydrolyses alpha-D-lyxosides and heptopyranosides with the
            same configuration at C-2, C-3 and C-4 as mannose.
PATHWAY     PATH: MAP00511  Glycoprotein degradation
GENES       BHA: BH0791
            TMA: TM1851
            SSO: SSO3006
            STO: ST1008
            DME: CG4606(alpha-Man-IIb) CG6206(BcDNA:GH02419)
            MMU: 107286(Man2b1)
            HSA: 4123(MAN2C1) 4125(MAN2B1)
STRUCTURES  PDB: 1FO2  1FO3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.24
            ExPASy - ENZYME nomenclature database: 3.2.1.24
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.24
            BRENDA, the Enzyme Database: 3.2.1.24
            SCOP (Structural Classification of Proteins): 3.2.1.24
///
ENTRY       EC 3.2.1.25
NAME        beta-Mannosidase
            Mannanase
            Mannase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Mannoside mannohydrolase
REACTION    Hydrolysis of terminal, non-reducing beta-D-mannose residues in
            beta-D-mannosides
SUBSTRATE   beta-D-Mannoside
            H2O
PRODUCT     beta-D-Mannose
PATHWAY     PATH: MAP00511  Glycoprotein degradation
GENES       XFA: XF0846
            SME: SMc04255(manB)
            CEL: C33G3.4
            HSA: 4126(MANBA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.25
            ExPASy - ENZYME nomenclature database: 3.2.1.25
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.25
            BRENDA, the Enzyme Database: 3.2.1.25
///
ENTRY       EC 3.2.1.26
NAME        beta-Fructofuranosidase
            Invertase
            Saccharase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Fructofuranoside fructohydrolase
REACTION    Hydrolysis of terminal non-reducing beta-D-fructofuranoside
            residues in beta-D-fructofuranosides
SUBSTRATE   beta-D-Fructofuranoside
            Sucrose
            H2O
PRODUCT     beta-D-Fructose
COMMENT     Substrates include sucrose; also catalyses fructotransferase
            reactions.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
GENES       ECE: Z3625
            ECS: ECs3243
            PMU: PM1848(scrB)
            VCH: VCA0655
            BSU: BG10596(sacA)
            BHA: BH1858(sacA)
            SAU: SA1846(scrB)
            SAV: SAV2025(scrB)
            SPY: SPy1816(scrB)
            SPN: SP1724 SP1795
            SPR: spr1568(scrB) spr1617(sacA)
            CAC: CAC0425(sacA)
            TMA: TM1414
            SCE: YIL162W(SUC2)
            SPO: INV1(inv1) SPAC8E11.01C(spac8e11.01c)
MOTIF       PS: PS00609  H-x(2)-P-x(4)-[LIVM]-N-D-P-N-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.26
            ExPASy - ENZYME nomenclature database: 3.2.1.26
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.26
            BRENDA, the Enzyme Database: 3.2.1.26
///
ENTRY       EC 3.2.1.27
NAME        Deleted entry
            alpha-1,3-Glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.27
            ExPASy - ENZYME nomenclature database: 3.2.1.27
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.27
///
ENTRY       EC 3.2.1.28
NAME        alpha,alpha-Trehalase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha,alpha-Trehalose glucohydrolase
REACTION    alpha,alpha'-Trehalose + H2O = 2 D-Glucose
SUBSTRATE   alpha,alpha'-Trehalose
            H2O
PRODUCT     D-Glucose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1197(treA) b3519(treF)
            ECE: Z1968(treA) Z4932(treF)
            ECS: ECs1701
            PAE: PA2416(treA)
            SCE: YBR001C(NTH2) YDR001C(NTH1) YPR026W(ATH1)
            SPO: SPBC660.07(spbc660.07)
            DME: CG9364_1
            HSA: 11181(TREH)
MOTIF       PS: PS00927  P-G-G-R-F-x-E-x-Y-x-W-D-x-Y
            PS: PS00928  Q-W-D-x-P-x-[GA]-W-[PAS]-P
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.28
            ExPASy - ENZYME nomenclature database: 3.2.1.28
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.28
            BRENDA, the Enzyme Database: 3.2.1.28
///
ENTRY       EC 3.2.1.29
NAME        Deleted entry
            Chitobiase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. See EC 3.2.1.30.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.29
            ExPASy - ENZYME nomenclature database: 3.2.1.29
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.29
///
ENTRY       EC 3.2.1.30
NAME        Deleted entry
            N-Acetyl-beta-glucosaminidase
            beta-D-Acetylglucosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Various examples of the enzyme act on
            N-acetyl-beta-D-galactos-aminides and chitobiose.
GENES       BSU: BG10455(lytD)
STRUCTURES  PDB: 1QBC  1QBD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.30
            ExPASy - ENZYME nomenclature database: 3.2.1.30
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.30
            BRENDA, the Enzyme Database: 3.2.1.30
            SCOP (Structural Classification of Proteins): 3.2.1.30
///
ENTRY       EC 3.2.1.31
NAME        beta-Glucuronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Glucuronoside glucuronosohydrolase
REACTION    a beta-D-Glucuronoside + H2O = an Alcohol + D-Glucuronate
SUBSTRATE   beta-D-Glucuronoside
            H2O
PRODUCT     D-Glucuronate
            Alcohol
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00531  Glycosaminoglycan degradation
            PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b1617(uidA)
            ECE: Z2621(uidA_1) Z2622(uidA_2)
            ECS: ECs2324 ECs2325
            TMA: TM1062
            SSO: SSO3036(gusB)
            DME: CG15117 CG2135
            MMU: 87951(Afp) 95872(Gus) 95874(Gus-s)
            HSA: 2990(GUSB)
DISEASE     MIM: 253220  Glucuronidase, beta-
MOTIF       PS: PS00608  [DENQLF]-[KRVW]-N-[HRY]-[STAPV]-[SAC]-[LIVMFS](3)-W-
                         [GS]-x(2,3)-N-E
            PS: PS00719  N-x-[LIVMFYWD]-R-[STACN](2)-H-Y-P-x(4)-[LIVMFYWS](2)-
                         x(3)-[DN]-x(2)-G-[LIVMFYW](4)
STRUCTURES  PDB: 1BHG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.31
            ExPASy - ENZYME nomenclature database: 3.2.1.31
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.31
            BRENDA, the Enzyme Database: 3.2.1.31
            SCOP (Structural Classification of Proteins): 3.2.1.31
///
ENTRY       EC 3.2.1.32
NAME        Xylan endo-1,3-beta-xylosidase
            Xylanase
            Endo-1,3-beta-xylanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-beta-D-Xylan xylanohydrolase
REACTION    Random hydrolysis of 1,3-beta-D-xylosidic linkages in
            1,3-beta-D-xylans
SUBSTRATE   1,3-beta-D-Xylan
            H2O
PRODUCT     1,3-beta-D-Xylan
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.32
            ExPASy - ENZYME nomenclature database: 3.2.1.32
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.32
            BRENDA, the Enzyme Database: 3.2.1.32
///
ENTRY       EC 3.2.1.33
NAME        Amylo-1,6-glucosidase
            Dextrin 6-alpha-D-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Dextrin 6-alpha-D-glucanohydrolase
REACTION    Endohydrolysis of 1,6-alpha-D-glucoside linkages at points of
            branching in chains of 1,4-linked-alpha-D-glucose residues
SUBSTRATE   Glycogen
            H2O
            Amylopectin
PRODUCT     Glycogen
            Amylopectin
COMMENT     In mammals and yeast this enzyme is linked to a glycosyl
            transferase similar to EC 2.4.1.25; together these two activities
            constitute the glycogen debranching system.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       CEL: R06A4.8
            DME: CG9485
            HSA: 178(AGL)
DISEASE     MIM: 232400  Amylo-1,6-glucosidase, 4-alpha-glucanotransferase
                         (glycogen
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.33
            ExPASy - ENZYME nomenclature database: 3.2.1.33
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.33
            BRENDA, the Enzyme Database: 3.2.1.33
///
ENTRY       EC 3.2.1.34
NAME        Deleted entry
            Chondroitinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.2.1.35.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.34
            ExPASy - ENZYME nomenclature database: 3.2.1.34
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.34
///
ENTRY       EC 3.2.1.35
NAME        Hyaluronoglucosaminidase
            Hyaluronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Hyaluronate 4-glycanohydrolase
REACTION    Random hydrolysis of 1,4-linkages between N-acetyl-beta-D-
            glucosamine and D-glucuronate residues in hyaluronate
SUBSTRATE   Hyaluronate
            H2O
            Chondroitin
            Chondroitin 4-sulfate
            Chondroitin 6-sulfate
            Dermatan
PRODUCT     Hyaluronate
COMMENT     Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-
            galactosamine or N-acetylgalactosamine sulfate and glucuronic acid
            in chondroitin, chondroitin 4- and 6- sulfates and dermatan.
GENES       SPY: SPy0701(hylP1)
            MMU: 96298(Hyal1)
            HSA: 3373(HYAL1) 6677(SPAM1)
DISEASE     MIM: 601492  Hyaluronoglucosaminidase 1
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
STRUCTURES  PDB: 1FCQ  1FCU  1FCV  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.35
            ExPASy - ENZYME nomenclature database: 3.2.1.35
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.35
            BRENDA, the Enzyme Database: 3.2.1.35
///
ENTRY       EC 3.2.1.36
NAME        Hyaluronoglucuronidase
            Hyaluronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Hyaluronate 3-glycanohydrolase
REACTION    Random hydrolysis of 1,3-linkages between beta-D-glucuronate and
            N-acetyl-D-glucosamine residues in hyaluronate
SUBSTRATE   Hyaluronate
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.36
            ExPASy - ENZYME nomenclature database: 3.2.1.36
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.36
            BRENDA, the Enzyme Database: 3.2.1.36
///
ENTRY       EC 3.2.1.37
NAME        Xylan 1,4-beta-xylosidase
            Xylobiase
            beta-Xylosidase
            Exo-1,4-beta-xylosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-beta-D-Xylan xylohydrolase
REACTION    Hydrolysis of 1,4-beta-D-xylans so as to remove successive
            D-xylose residues from the non-reducing termini.
SUBSTRATE   1,4-beta-D-Xylan
            H2O
            Xylobiose
PRODUCT     D-Xylose
            1,4-beta-D-Xylan
COMMENT     Also hydrolyses xylobiose. Some other exoglycosidase activities
            have been found associated with this enzyme in sheep liver.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b0271(yagH)
            SME: SMc04247
            CCR: CC0989 CC2357
            BSU: BG11987(xynB)
            BHA: BH1068 BH3683(xynB)
            LLA: L0234(xynB)
            CAC: CAC3452(xynD)
MOTIF       PS: PS00775  [LIVM](2)-[KR]-x-[EQK]-x(4)-G-[LIVMFT]-[LIVT]-[LIVMF]-
                         [ST]-D-x(2)-[SGADNI]
            PS: PS01027  W-x-F-E-x-W-N-E-P-[DN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.37
            ExPASy - ENZYME nomenclature database: 3.2.1.37
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.37
            BRENDA, the Enzyme Database: 3.2.1.37
///
ENTRY       EC 3.2.1.38
NAME        beta-D-Fucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Fucoside fucohydrolase
REACTION    Hydrolysis of terminal non-reducing beta-D-fucose residues in
            beta-D-fucosides
SUBSTRATE   beta-D-Fucoside
            H2O
PRODUCT     beta-D-Fucose
COMMENT     Enzymes from some sources also hydolyse beta-D-galactosides and/or
            beta-D-glucosides and/or alpha-L-arabinosides.  The activity of
            EC 3.2.1.37 is an associated activity found in some sources (e.g.
            liver).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.38
            ExPASy - ENZYME nomenclature database: 3.2.1.38
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.38
            BRENDA, the Enzyme Database: 3.2.1.38
///
ENTRY       EC 3.2.1.39
NAME        Glucan endo-1,3-beta-D-glucosidase
            Endo-1,3-beta-glucanase
            Laminarinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-beta-D-Glucan glucanohydrolase
REACTION    Hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D-glucans
SUBSTRATE   1,3-beta-D-Glucan
            H2O
            Laminarin
            Paramylon
            Pachyman
PRODUCT     1,3-beta-D-Glucan
COMMENT     Different from EC 3.2.1.6. Very limited action on mixed-link
            (1,3-1,4-)-beta-D-glucans. Hydrolyses laminarin, paramylon and
            pachyman.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ATH: At4g14080(dl3080c)
MOTIF       PS: PS00587  [LIVM]-x-[LIVMFYWA](3)-[STAG]-E-[STA]-G-W-P-[STN]-x-
                         [SAGQ]
            PS: PS01034  E-[LIV]-D-[LIVF]-x(0,1)-E-x(2)-[GQ]-[KRNF]-x-[PSTA]
STRUCTURES  PDB: 1GHS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.39
            ExPASy - ENZYME nomenclature database: 3.2.1.39
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.39
            BRENDA, the Enzyme Database: 3.2.1.39
            SCOP (Structural Classification of Proteins): 3.2.1.39
///
ENTRY       EC 3.2.1.40
NAME        alpha-L-Rhamnosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-L-Rhamnoside rhamnohydrolase
REACTION    Hydrolysis of terminal, non-reducing alpha-L-rhamnose residues in
            alpha-L-rhamnosides
SUBSTRATE   alpha-L-Rhamnoside
            H2O
PRODUCT     alpha-L-Rhamnose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.40
            ExPASy - ENZYME nomenclature database: 3.2.1.40
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.40
            BRENDA, the Enzyme Database: 3.2.1.40
///
ENTRY       EC 3.2.1.41
NAME        alpha-Dextrin endo-1,6-alpha-glucosidase
            Limit dextrinase
            Debranching enzyme
            Amylopectin 6-glucanohydrolase
            Pullulanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-Dextrin 6-glucanohydrolase
REACTION    Hydrolysis of 1,6-alpha-D-glucosidic linkages in pullulan,
            amylopectin and glycogen, and in the alpha- and beta-amylase
            limit dextrins of amylopectin and glycogen.
SUBSTRATE   Pullulan
            Amylopectin
            Glycogen
            H2O
            Limit dextrin
PRODUCT     alpha-D-Glucose
            Dextrin
COMMENT     cf. EC 3.2.1.68, 3.2.1.57 and 3.2.1.135.
GENES       BSU: BG12566(amyX)
            BHA: BH3264(amyX)
            SPN: SP1118
            SPR: spr1025(pulI)
            CAC: CAC2679
            MPU: MYPU_6440(pulA)
            DRA: DR0405
            TMA: TM1845
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS01072  [LVFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[FYWPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,6)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.41
            ExPASy - ENZYME nomenclature database: 3.2.1.41
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.41
            BRENDA, the Enzyme Database: 3.2.1.41
///
ENTRY       EC 3.2.1.42
NAME        GDPglucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     GDPglucose glucohydrolase
REACTION    GDPglucose + H2O = GDP + D-Glucose
SUBSTRATE   GDPglucose
            H2O
PRODUCT     GDP
            D-Glucose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.42
            ExPASy - ENZYME nomenclature database: 3.2.1.42
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.42
            BRENDA, the Enzyme Database: 3.2.1.42
///
ENTRY       EC 3.2.1.43
NAME        beta-L-Rhamnosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-L-Rhamnoside rhamnohydrolase
REACTION    Hydrolysis of terminal, non-reducing beta-L-rhamnose residues in
            beta-L-Rhamnosides
SUBSTRATE   beta-L-Rhamnoside
            H2O
PRODUCT     beta-L-Rhamnose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.43
            ExPASy - ENZYME nomenclature database: 3.2.1.43
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.43
            BRENDA, the Enzyme Database: 3.2.1.43
///
ENTRY       EC 3.2.1.44
NAME        Fucoidanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase
REACTION    Endohydrolysis of 1,2-alpha-L-fucoside linkages in fucosidan
            without release of sulfate
SUBSTRATE   Fucosidan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.44
            ExPASy - ENZYME nomenclature database: 3.2.1.44
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.44
            BRENDA, the Enzyme Database: 3.2.1.44
///
ENTRY       EC 3.2.1.45
NAME        Glucosylceramidase
            Psychosine hydrolase
            Glucosphingosine glucosylhydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     D-Glucosyl-N-acylsphingosine glucohydrolase
REACTION    D-Glucosyl-N-acylsphingosine + H2O = D-Glucose + N-Acylsphingosine
SUBSTRATE   D-Glucosyl-N-acylsphingosine
            H2O
PRODUCT     D-Glucose
            N-Acylsphingosine
COMMENT     Also acts on glucosylsphingosine
            (cf. EC 3.2.1.62: Glycosylceramidase).
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       CEL: C33C12.3 C33C12.8
            MMU: 95665(Gba)
            HSA: 2629(GBA)
DISEASE     MIM: 230800  Glucosidase, acid beta
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.45
            ExPASy - ENZYME nomenclature database: 3.2.1.45
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.45
            BRENDA, the Enzyme Database: 3.2.1.45
///
ENTRY       EC 3.2.1.46
NAME        Galactosylceramidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     D-Galactosyl-N-acylsphingosine galactohydrolase
REACTION    D-Galactosyl-N-acylsphingosine + H2O = D-Galactose +
            N-Acylsphingosine
SUBSTRATE   D-Galactosyl-N-acylsphingosine
            H2O
PRODUCT     D-Galactose
            N-Acylsphingosine
COMMENT     cf. EC 3.2.1.62.
GENES       MMU: 95636(Galc)
            HSA: 2581(GALC)
DISEASE     MIM: 245200  Galactosylceraminidase
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.46
            ExPASy - ENZYME nomenclature database: 3.2.1.46
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.46
            BRENDA, the Enzyme Database: 3.2.1.46
///
ENTRY       EC 3.2.1.47
NAME        Galactosylgalactosylglucosylceramidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     D-Galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine
            $ galactohydrolase
REACTION    D-Galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O =
            Lactosyl-N-acylsphingosine + D-Galactose
SUBSTRATE   D-Galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine
            H2O
PRODUCT     Lactosyl-N-acylsphingosine
            D-Galactose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.47
            ExPASy - ENZYME nomenclature database: 3.2.1.47
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.47
            BRENDA, the Enzyme Database: 3.2.1.47
///
ENTRY       EC 3.2.1.48
NAME        Sucrose alpha-glucosidase
            Sucrose alpha-glucohydrolase
            Sucrase
            Sucrase-isomaltase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Sucrose alpha-D-glucohydrolase
REACTION    Hydrolysis of sucrose and maltose by an alpha-D-glucosidase-type
            action
SUBSTRATE   Sucrose
            Maltose
            Isomaltose
            H2O
PRODUCT     alpha-D-Glucose
COMMENT     This enzyme is isolated from intestinal mucosa as a single
            polypeptide chain also displaying activity towards isomaltose
            (oligo-1,6-glucosidase, EC 3.2.1.10).
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       HSA: 6476
MOTIF       PS: PS00025  [KR]-x(2)-C-x-[FYPST]-x(3,4)-[ST]-x(3)-C-x(4)-C-C-
                         [FYWH]
            PS: PS00129  [GF]-[LIVMF]-W-x-D-M-[NSA]-E
            PS: PS00707  G-[AV]-D-[LIVMTA]-C-G-[FY]-x(3)-[ST]-x(3)-L-C-x-R-W-
                         x(2)-[LV]-[GSA]-[SA]-F-x-P-F-x-R-[DN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.48
            ExPASy - ENZYME nomenclature database: 3.2.1.48
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.48
            BRENDA, the Enzyme Database: 3.2.1.48
///
ENTRY       EC 3.2.1.49
NAME        alpha-N-Acetylgalactosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
REACTION    Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine
            residues in N-acetyl-alpha-D-galactosaminides
SUBSTRATE   N-Acetyl-alpha-D-galactosaminide
            H2O
PRODUCT     N-Acetyl-D-galactosamine
COMMENT     Splits N-acetylgalactosaminyl groups from O-3 of Ser and Thr.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: 4668(NAGA)
DISEASE     MIM: 104170  Acetylgalactosaminidase, alpha-N- (alpha-galactosidase
                         B)
MOTIF       PS: PS00512  G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-D-x-W-x(3,4)-R-
                         [DNSF]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.49
            ExPASy - ENZYME nomenclature database: 3.2.1.49
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.49
            BRENDA, the Enzyme Database: 3.2.1.49
///
ENTRY       EC 3.2.1.50
NAME        alpha-N-Acetylglucosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-N-Acetyl-D-glucosaminide N-acetylglucosaminohydrolase
REACTION    Hydrolysis of terminal, non-reducing N-acetyl-D-glucosamine
            residues in N-acetyl-alpha-D-glucosaminides
SUBSTRATE   N-Acetyl-alpha-D-glucosaminide
            H2O
PRODUCT     N-Acetyl-D-glucosamine
COMMENT     HYdrolyses UDP-N-acetylglucosamine.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
            PATH: MAP00531  Glycosaminoglycan degradation
GENES       HSA: 4669(NAGLU)
DISEASE     MIM: 252920  N-acetylglucosaminidase, alpha-
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.50
            ExPASy - ENZYME nomenclature database: 3.2.1.50
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.50
            BRENDA, the Enzyme Database: 3.2.1.50
///
ENTRY       EC 3.2.1.51
NAME        alpha-L-Fucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-L-Fucoside fucohydrolase
REACTION    an alpha-D-Fucoside + H2O = an Alcohol + L-Fucose
SUBSTRATE   alpha-L-Fucoside
            H2O
PRODUCT     Alcohol
            L-Fucose
PATHWAY     PATH: MAP00511  Glycoprotein degradation
GENES       TMA: TM0306
            SSO: SSO11867(fucA1) SSO3060(fucA1)
            CEL: W03G11.3
            DME: CG6128
            MMU: 95593(Fuca)
            HSA: 2517(FUCA1) 2519(FUCA2)
DISEASE     MIM: 230000  Fucosidase, alpha-L- 1, tissue
MOTIF       PS: PS00385  P-x(2)-L-x(3)-K-W-E-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.51
            ExPASy - ENZYME nomenclature database: 3.2.1.51
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.51
            BRENDA, the Enzyme Database: 3.2.1.51
///
ENTRY       EC 3.2.1.52
NAME        beta-N-Acetylhexosaminidase
            Hexosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
REACTION    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
            residues in N-acetyl-beta-D-hexosaminides
SUBSTRATE   N-Acetyl-beta-D-hexosaminide
            H2O
            N-Acetyl-D-glucosaminide
            N-Acetyl-D-galactosaminide
PRODUCT     N-Acetyl-D-hexosamine
            N-Acetyl-D-glucosamine
            N-Acetyl-D-galactosamine
COMMENT     Acts on N-acetylglucosides and N-acetylgalactosides.
PATHWAY     PATH: MAP00511  Glycoprotein degradation
            PATH: MAP00530  Aminosugars metabolism
            PATH: MAP00531  Glycosaminoglycan degradation
            PATH: MAP00600  Sphingoglycolipid metabolism
GENES       ECO: b1107(ycfO)
            ECE: Z1746(ycfO)
            ECS: ECs1485
            YPE: YPO1615(ycfO) YPO2632(chb)
            HIN: HI0959
            PMU: PM0071
            XFA: XF0847 XF2355
            VCH: VC0613 VC0692 VC2217
            PAE: PA3005
            NME: NMB0530
            NMA: NMA0708
            CCR: CC0447
            BSU: BG10832(ybbD)
            BHA: BH0675
            SPN: SP0057
            SPR: spr0057(strH)
            CAC: CAC0182
            BBU: BB0002
            ATH: At1g05590(F3F20.4)
            CEL: T14F9.3
            DME: CG1318 CG1787_1 CG8824
            MMU: 96074(Hexb)
            HSA: 3073(HEXA) 3074(HEXB)
DISEASE     MIM: 268800  Hexosaminidase B, beta polypeptide
            MIM: 272800  Hexosaminidase A, alpha polypeptide
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00775  [LIVM](2)-[KR]-x-[EQK]-x(4)-G-[LIVMFT]-[LIVT]-[LIVMF]-
                         [ST]-D-x(2)-[SGADNI]
STRUCTURES  PDB: 1C7S  1C7T  1HP4  1HP5  1QBA  1QBB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.52
            ExPASy - ENZYME nomenclature database: 3.2.1.52
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.52
            BRENDA, the Enzyme Database: 3.2.1.52
            SCOP (Structural Classification of Proteins): 3.2.1.52
///
ENTRY       EC 3.2.1.53
NAME        beta-N-Acetylgalactosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
REACTION    Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine
            residues in N-acetyl-beta-D-galactosaminides
SUBSTRATE   N-Acetyl-beta-D-galactosaminide
            H2O
PRODUCT     N-Acetyl-D-galactosamine
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.53
            ExPASy - ENZYME nomenclature database: 3.2.1.53
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.53
            BRENDA, the Enzyme Database: 3.2.1.53
///
ENTRY       EC 3.2.1.54
NAME        Cyclomaltodextrinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Cyclomaltodextrin dextrin-hydrolase (decyclizing)
REACTION    Cyclomaltodextrin + H2O = Linear maltodextrin
SUBSTRATE   Cyclomaltodextrin
            H2O
            Linear maltodextrin
PRODUCT     Linear maltodextrin
COMMENT     Also hydrolyses linear maltodextin.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.54
            ExPASy - ENZYME nomenclature database: 3.2.1.54
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.54
            BRENDA, the Enzyme Database: 3.2.1.54
///
ENTRY       EC 3.2.1.55
NAME        alpha-N-Arabinofuranosidase
            Arabinosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-L-Arabinofuranoside arabinofuranohydrolase
REACTION    Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside
            residues in alpha-L-arabinosides
SUBSTRATE   alpha-L-Arabinoside
            alpha-L-Arabinofuranoside
            alpha-L-Arabinan
            Arabinoxylan
            Arabinogalactan
PRODUCT     alpha-L-Arabinoside
            alpha-L-Arabinofuranoside
COMMENT     The enzyme acts on alpha-L-arabinofuranosides, alpha-L-arabinans
            containing (1,3)- and/or (1,5)-linkages, arabinoxylans and
            arabinogalactans.  Some beta-galactosidases (EC 3.2.1.23) and
            beta-D-fucosidases (EC 3.2.1.38) also hydrolyse
            alpha-L-arabinosides.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
GENES       MLO: mll3591
            SME: SMb20924(abfA)
            CCR: CC1422
            BSU: BG11900(abfA) BG11985(xsa)
            BHA: BH1861(abfA) BH1874(xsa)
            SYN: slr0518(abfB)
            TMA: TM0281
MOTIF       PS: PS00561  W-N-[STAGR]-[STDN]-[LIVM]-x(2)-[GST]-x-[GST]-x(2)-
                         [LIVMFT]-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.55
            ExPASy - ENZYME nomenclature database: 3.2.1.55
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.55
            BRENDA, the Enzyme Database: 3.2.1.55
///
ENTRY       EC 3.2.1.56
NAME        Glucuronosyl-disulfoglucosamine glucuronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     3-D-Glucuronosyl-N2,6-disulfo-beta-D-glucosamine
            $ glucuronohydrolase
REACTION    3-D-Glucuronosyl-N2,6-disulfo-beta-D-glucosamine + H2O =
            N2,6-Disulfo-D-glucosamine + D-Glucuronate
SUBSTRATE   3-D-Glucuronosyl-N2,6-disulfo-beta-D-glucosamine
            H2O
PRODUCT     D-Glucuronate
            N2,6-Disulfo-D-glucosamine
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.56
            ExPASy - ENZYME nomenclature database: 3.2.1.56
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.56
            BRENDA, the Enzyme Database: 3.2.1.56
///
ENTRY       EC 3.2.1.57
NAME        Isopullulanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Pullulan 4-glucanohydrolase (isopanose-forming)
REACTION    Hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose)
SUBSTRATE   Pullulan
            H2O
            Panose
PRODUCT     6-alpha-Maltosylglucose
            Isomaltose
            D-Glucose
COMMENT     The enzyme has practically no action on starch.  Panose
            (4-alpha-isomaltosylaglucose) is hydrolysed to isomaltose and
            glucose.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.57
            ExPASy - ENZYME nomenclature database: 3.2.1.57
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.57
            BRENDA, the Enzyme Database: 3.2.1.57
///
ENTRY       EC 3.2.1.58
NAME        Glucan 1,3-beta-glucosidase
            Exo-1,3-beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-beta-Glucan glucohydrolase
REACTION    Successive hydrolysis of beta-D-glucose units from the
            non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose
SUBSTRATE   1,3-beta-D-Glucan
            H2O
            Laminaribiose
PRODUCT     1,3-beta-D-Glucan
            alpha-D-Glucose
COMMENT     Acts on oligosaccharides but very slowly on laminaribiose.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SCE: YDR261C(EXG2) YGR282C(BGL2) YLR300W(EXG1) YOR190W(SPR1)
            SPO: SPAC12B10.11(spac12b10.11) SPBC1105.05(spbc1105.05)
                 SPBC2D10.05(spbc2d10.05)
MOTIF       PS: PS00587  [LIVM]-x-[LIVMFYWA](3)-[STAG]-E-[STA]-G-W-P-[STN]-x-
                         [SAGQ]
            PS: PS00659  [LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-x-N-E-[PV]-
                         [RHDNSTLIVFY]
STRUCTURES  PDB: 1EQC  1EQP  1CZ1  1EX1  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.58
            ExPASy - ENZYME nomenclature database: 3.2.1.58
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.58
            BRENDA, the Enzyme Database: 3.2.1.58
            SCOP (Structural Classification of Proteins): 3.2.1.58
///
ENTRY       EC 3.2.1.59
NAME        Glucan endo-1,3-alpha-glucosidase
            Endo-1,3-alpha-glucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3(1,3:1,4)-alpha-D-Glucan 3-glucanohydrolase
REACTION    Endohydrolysis of 1,3-alpha-D-glucosidic linkages in isolichenin,
            psuedonigeran and nigeran
SUBSTRATE   Isolichenin
            Psuedonigeran
            Nigeran
            H2O
PRODUCT     Nigerose
            alpha-D-Glucose
COMMENT     Products from pseudonigeran (1,3-alpha-D-glucan) are nigerose and
            alpha-D-glucose.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.59
            ExPASy - ENZYME nomenclature database: 3.2.1.59
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.59
            BRENDA, the Enzyme Database: 3.2.1.59
///
ENTRY       EC 3.2.1.60
NAME        Glucan 1,4-alpha-maltotetraohydrolase
            Exo-maltotetraohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan maltotetraohydrolase
REACTION    Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous
            polysaccharides so as to remove successive maltotetraose
            residues from the non-reducing chain ends
SUBSTRATE   Amylaceous polysaccharide
            H2O
PRODUCT     Maltotetraose
COMMENT     Compare EC 3.2.1.2, beta-amylase, which removes successive
            maltose residues, and EC 3.2.1.98 and 3.2.1.116.
STRUCTURES  PDB: 1JDA  1JDC  1JDD  1QI3  1QI4  1QI5  2AMG  1GCY  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.60
            ExPASy - ENZYME nomenclature database: 3.2.1.60
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.60
            BRENDA, the Enzyme Database: 3.2.1.60
            SCOP (Structural Classification of Proteins): 3.2.1.60
///
ENTRY       EC 3.2.1.61
NAME        Mycodextranase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-1,4-alpha-D-Glucan 4-glucanohydrolase
REACTION    Endohydrolysis of 1,4-alpha-D-glucosidic linkages in
            alpha-D-glucans containing both 1,3- and 1,4-bonds
SUBSTRATE   alpha-D-Glucan
            H2O
COMMENT     Products are nigerose and 4-alpha-D-nigerosylglucose.  No
            hydrolysis of alpha-D-glucans containing only 1,3- or 1,4- bonds.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.61
            ExPASy - ENZYME nomenclature database: 3.2.1.61
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.61
            BRENDA, the Enzyme Database: 3.2.1.61
///
ENTRY       EC 3.2.1.62
NAME        Glycosylceramidase
            Phlorizin hydrolase
            Phloretin-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycosyl-N-acylsphingosine glycohydrolase
REACTION    Glycosyl-N-acylsphingosine + H2O = a Sugar + N-Acylsphingosine
SUBSTRATE   Glycosyl-N-acylsphingosine
            H2O
            Phlorizin
PRODUCT     Sugar
            N-Acylsphingosine
            Phloretin
            Glucose
COMMENT     Broad specificity (cf. EC 3.2.1.45 and 3.2.1.46). Also hydrolyses
            phlorizin to phloretin and glucose. The intestinal enzyme is a
            complex which also catalyses the reaction of EC 3.2.1.108.
GENES       HSA: 3938(LCT)
DISEASE     MIM: 603202  Lactase
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.62
            ExPASy - ENZYME nomenclature database: 3.2.1.62
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.62
            BRENDA, the Enzyme Database: 3.2.1.62
///
ENTRY       EC 3.2.1.63
NAME        1,2-alpha-L-Fucosidase
            Almond emulsin fucosidase II
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     2-alpha-L-FUcopyranosyl-beta-D-galactoside fucohydrolase
REACTION    Methyl-2-alpha-L-Fucopyranosyl-beta-D-galactoside + H2O = L-Fucose
            + Methyl beta-D-galactoside
SUBSTRATE   Methyl-2-alpha-L-Fucopyranosyl-beta-D-galactoside
            H2O
PRODUCT     L-Fucose
            Methyl beta-D-galactoside
COMMENT     Highly specific for non-reducing terminal L-fuxose residues linked
            to D-galactose residues by 1,2-alpha-linkage.  Not identical with
            EC 3.2.1.111.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.63
            ExPASy - ENZYME nomenclature database: 3.2.1.63
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.63
            BRENDA, the Enzyme Database: 3.2.1.63
///
ENTRY       EC 3.2.1.64
NAME        2,6-beta-Fructan 6-levanbiohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     2,6-beta-D-Fructan 6-beta-D-fructofuranosylfructohydrolase
REACTION    Hydrolysis of 2,6-beta-D-fructan so as to remove successive
            levanbiose residues from the end of the chain.
SUBSTRATE   2,6-beta-D-Fructan
            H2O
PRODUCT     Levanbiose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.64
            ExPASy - ENZYME nomenclature database: 3.2.1.64
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.64
            BRENDA, the Enzyme Database: 3.2.1.64
///
ENTRY       EC 3.2.1.65
NAME        Levanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     2,6-beta-D-Fructan fructanohydrolase
REACTION    Random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in
            2,6-beta-D-fructans (levans) containing more than 3 fructose units
SUBSTRATE   2,6-beta-D-Fructan
            H2O
PRODUCT     2,6-beta-D-Fructan
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       BSU: BG10320(sacC)
MOTIF       PS: PS00609  H-x(2)-P-x(4)-[LIVM]-N-D-P-N-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.65
            ExPASy - ENZYME nomenclature database: 3.2.1.65
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.65
            BRENDA, the Enzyme Database: 3.2.1.65
///
ENTRY       EC 3.2.1.66
NAME        Quercitrinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Quercitrin 3-L-rhamnohydrolase
REACTION    Quercitrin + H2O = L-Rhamnose + Quercetin
SUBSTRATE   Quercitrin
            H2O
PRODUCT     L-Rhamnose
            Quercetin
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.66
            ExPASy - ENZYME nomenclature database: 3.2.1.66
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.66
            BRENDA, the Enzyme Database: 3.2.1.66
///
ENTRY       EC 3.2.1.67
NAME        Galacturan 1,4-alpha-galacturonidase
            Exopolygalacturonase
            Poly(galacturonate) hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(1,4-alpha-D-galacturonide) galacturonohydrolase
REACTION    (1,4-alpha-D-Galacturonide)n + H2O =
            (1,4-alpha-D-Galacturonide)n-1 + D-Galacturonate
SUBSTRATE   (1,4-alpha-D-Galacturonide)n
            H2O
PRODUCT     (1,4-alpha-D-Galacturonide)n-1
            D-Galacturonate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
MOTIF       PS: PS00502  [GSDENKRH]-x(2)-[VMFC]-x(2)-[GS]-H-G-[LIVMAG]-x(1,2)-
                         [LIVM]-G-S
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.67
            ExPASy - ENZYME nomenclature database: 3.2.1.67
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.67
            BRENDA, the Enzyme Database: 3.2.1.67
///
ENTRY       EC 3.2.1.68
NAME        Isoamylase
            Debranching enzyme
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycogen 6-glucanohydrolase
REACTION    Hydrolysis of 1,6-alpha-D-glucosidic branch linkages in glycogen,
            amylopectin and thier beta-limit dextrins
SUBSTRATE   Glycogen
            Amylopectin
            beta-Limit dextrin
            H2O
PRODUCT     D-Glucose
COMMENT     Distinguished from alpha-dextrin endo-1,6-alpha-glucosidase
            (EC 3.2.1.41) by the inability of isoamylase to attack pullulan,
            and by limited action on alpha-limit dextrins. Action on
            glycogen however is complete in contrast to limited action by
            alpha-dextrin glucanohydrolase. 1,6-Linkage hydrolysed only if at
            a branch point.
STRUCTURES  PDB: 1BF2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.68
            ExPASy - ENZYME nomenclature database: 3.2.1.68
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.68
            BRENDA, the Enzyme Database: 3.2.1.68
            SCOP (Structural Classification of Proteins): 3.2.1.68
///
ENTRY       EC 3.2.1.69
NAME        Deleted entry
            Amylopectin 6-glucanohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.2.1.41.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.69
            ExPASy - ENZYME nomenclature database: 3.2.1.69
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.69
///
ENTRY       EC 3.2.1.70
NAME        Glucan 1,6-alpha-glucosidase
            Exo-1,6-alpha-glucosidase
            Glucodextrinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-alpha-D-Glucan glucohydrolase
REACTION    Hydrolysis of successive glucose residues from 1,6-alpha-D-
            $glucans and derived oligosaccharides
SUBSTRATE   1,6-alpha-D-Glucan
            H2O
            Isomaltosaccharide
            Isomaltose
PRODUCT     D-Glucose
COMMENT     beta-D-Glucose is formed by an inversion. Dextrans and
            isomaltosaccharides are attacked and, very slowly, isomaltose.
            Some members of this group attack 1,3-alpha-D-glucosidic
            bonds in dextrans.
GENES       LLA: L124628(dexB)
            SPR: spr0310(dexB)
            MPU: MYPU_4630(dexB)
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.70
            ExPASy - ENZYME nomenclature database: 3.2.1.70
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.70
            BRENDA, the Enzyme Database: 3.2.1.70
///
ENTRY       EC 3.2.1.71
NAME        Glucan endo-1,2-beta-glucosidase
            Endo-1,2-beta-glucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,2-beta-D-Glucan glucanohydrolase
REACTION    Random hydrolysis of 1,2-glucosidic linkages in 1,2-beta-D-glucans
SUBSTRATE   1,2-beta-D-Glucan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.71
            ExPASy - ENZYME nomenclature database: 3.2.1.71
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.71
            BRENDA, the Enzyme Database: 3.2.1.71
///
ENTRY       EC 3.2.1.72
NAME        Xylan 1,3-beta-xylosidase
            Exo-1,3-beta-xylosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-beta-D-Xylan xylohydrolase
REACTION    Hydrolysis of syccessive xylose residues from the non-reducing
            terimini of 1,3-beta-D-xylans
SUBSTRATE   1,3-beta-D-Xylan
            H2O
PRODUCT     Xylose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.72
            ExPASy - ENZYME nomenclature database: 3.2.1.72
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.72
            BRENDA, the Enzyme Database: 3.2.1.72
///
ENTRY       EC 3.2.1.73
NAME        Licheninase
            Lichenase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-1,4-beta-D-Glucan 4-glucanohydrolase
REACTION    Hydrolysis of 1,4-beta-D-glucosidic linkages in beta-D-glucans
            containing 1,3- and 1,4-bonds
SUBSTRATE   beta-D-Glucan
            H2O
            Lichenin
PRODUCT     D-Glucose
COMMENT     Acts on lichenin and cereal beta-D-glucans, but not on
            beta-D-glucans containing only 1,3- or 1.4- bonds.
GENES       BSU: BG10476(bglS)
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00448  D-[LIVMFY]-[DNV]-x-[DNS]-x(2)-[LIVM]-[DN]-[SALM]-x-D-
                         x(3)-[LIVMF]-x-[RKS]-x-[LIVMF]
            PS: PS00587  [LIVM]-x-[LIVMFYWA](3)-[STAG]-E-[STA]-G-W-P-[STN]-x-
                         [SAGQ]
            PS: PS00776  [PSA]-[LQ]-x-E-Y-Y-[LIVM](2)-[DE]-x-[FYWHN]
            PS: PS00777  [LIVMF]-x(2)-E-[AG]-[YWG]-[QRFGS]-[SG]-[STAN]-G-x-[SAF]
            PS: PS00812  A-[ST]-D-[AG]-D-x(2)-[IM]-A-x-[SA]-[LIVM]-[LIVMG]-x-A-
                         x(3)-[FW]
            PS: PS01034  E-[LIV]-D-[LIVF]-x(0,1)-E-x(2)-[GQ]-[KRNF]-x-[PSTA]
STRUCTURES  PDB: 1CPN  1GLH  1GHR  1GBG  1AJK  2AYH  1MAC  1CPM  1BYH  1AXK  
                 1AQ0  1AJO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.73
            ExPASy - ENZYME nomenclature database: 3.2.1.73
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.73
            BRENDA, the Enzyme Database: 3.2.1.73
            SCOP (Structural Classification of Proteins): 3.2.1.73
///
ENTRY       EC 3.2.1.74
NAME        Glucan 1,4-beta-glucosidase
            Exo-1,4-beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-beta-D-Glucan glucohydrolase
REACTION    Hydrolysis of 1,4-linkages in 1,4-beta-D-glucans so as to remove
            successive glucose units
SUBSTRATE   1,4-beta-D-Glucan
            H2O
PRODUCT     D-Glucose
COMMENT     Acts on 1,4-beta-D-glucans and related oligosaccharides.
            Cellobiose is hydrolysed, very slowly.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.74
            ExPASy - ENZYME nomenclature database: 3.2.1.74
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.74
            BRENDA, the Enzyme Database: 3.2.1.74
///
ENTRY       EC 3.2.1.75
NAME        Glucan endo-1,6-beta-glucosidase
            Endo-1,6-beta-glucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-beta-D-Glucan glucohydrolase
REACTION    Random hydrolysis of 1,6-linkages in 1,6-beta-D-glucans
SUBSTRATE   1,6-beta-D-Glucan
            H2O
COMMENT     Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.75
            ExPASy - ENZYME nomenclature database: 3.2.1.75
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.75
            BRENDA, the Enzyme Database: 3.2.1.75
///
ENTRY       EC 3.2.1.76
NAME        L-Iduronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycosaminoglycan alpha-L-iduronohydrolase
REACTION    Hydrolysis of unsulfated alpha-L-iduronosidic linkages in
            dermatan sulfate
SUBSTRATE   Dermatan sulfate
            H2O
PRODUCT     Dermatan sulfate
PATHWAY     PATH: MAP00531  Glycosaminoglycan degradation
GENES       MMU: 96418(Idua)
            HSA: 3425(IDUA)
DISEASE     MIM: 252800  Iduronidase, alpha-L-
MOTIF       PS: PS01027  W-x-F-E-x-W-N-E-P-[DN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.76
            ExPASy - ENZYME nomenclature database: 3.2.1.76
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.76
            BRENDA, the Enzyme Database: 3.2.1.76
///
ENTRY       EC 3.2.1.77
NAME        Mannan 1,2-(1,3)-alpha-mannosidase
            Exo-1,2-1,3-alpha-mannosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,2-1,3-alpha-D-Mannan mannohydrolase
REACTION    Hydrolysis of 1,2- and 1,3-linkages in yeast mannan, releasing
            mannose
SUBSTRATE   Mannan
            H2O
PRODUCT     D-Mannose
COMMENT     A 1,6-alpha-D-mannan backbone remains after action on yeast
            mannan.  This is further attacked, but alowly.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.77
            ExPASy - ENZYME nomenclature database: 3.2.1.77
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.77
            BRENDA, the Enzyme Database: 3.2.1.77
///
ENTRY       EC 3.2.1.78
NAME        Mannan endo-1,4-beta-mannosidase
            Endo-1,4-beta-mannanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-beta-Mannan mannanohydrolase
REACTION    Random hydrolysis of 1,4-beta-D-mannosidic linkages in
            mannans, galactomannans and glucomannans
SUBSTRATE   Mannan
            Galactomannan
            Glucomannan
            H2O
PRODUCT     Mannan
            Galactomannan
            Glucomannan
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       BSU: BG12197(ydhT)
MOTIF       PS: PS00659  [LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-x-N-E-[PV]-
                         [RHDNSTLIVFY]
STRUCTURES  PDB: 1J9Y  1BQC  1QNR  1QNQ  1QNO  1QNS  1QNP  2MAN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.78
            ExPASy - ENZYME nomenclature database: 3.2.1.78
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.78
            BRENDA, the Enzyme Database: 3.2.1.78
            SCOP (Structural Classification of Proteins): 3.2.1.78
///
ENTRY       EC 3.2.1.79
NAME        Deleted entry
            alpha-L-Arabinofuranoside hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.2.1.55.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.79
            ExPASy - ENZYME nomenclature database: 3.2.1.79
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.79
///
ENTRY       EC 3.2.1.80
NAME        Fructan beta-fructosidase
            Exo-beta-D-fructosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Fructan fructohydrolase
REACTION    Hydrolysis of terminal, non-reducing 2,1- and 2,6-linked
            beta-D-fructofuranose residues in fructans
SUBSTRATE   beta-D-Fructan
            H2O
            Inulin
            Levan
PRODUCT     beta-D-Fructan
            D-Fructose
COMMENT     Hydrolyses inulin and levan, and also sucrose.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
MOTIF       PS: PS00609  H-x(2)-P-x(4)-[LIVM]-N-D-P-N-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.80
            ExPASy - ENZYME nomenclature database: 3.2.1.80
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.80
            BRENDA, the Enzyme Database: 3.2.1.80
///
ENTRY       EC 3.2.1.81
NAME        Agarase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Agarose 3-glycanohydrolase
REACTION    Hydrolysis of 1,3-beta-D-galactosidic linkages in agarose,
            giving the tetramer as the predominant product
SUBSTRATE   Agarose
            H2O
            Porphyran
PRODUCT     Agarose
            D-Galactose
COMMENT     Also acts on porphyran
MOTIF       PS: PS01034  E-[LIV]-D-[LIVF]-x(0,1)-E-x(2)-[GQ]-[KRNF]-x-[PSTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.81
            ExPASy - ENZYME nomenclature database: 3.2.1.81
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.81
            BRENDA, the Enzyme Database: 3.2.1.81
///
ENTRY       EC 3.2.1.82
NAME        Exo-poly-alpha-galacturonosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(1,4-alpha-D-galactosiduronate)digalacturonohydrolase
REACTION    Hydrolysis of pectic acid from the non-reducing end,
            releasing digalacturonate.
SUBSTRATE   Pectic acid
            H2O
PRODUCT     Digalacturonate
MOTIF       PS: PS00502  [GSDENKRH]-x(2)-[VMFC]-x(2)-[GS]-H-G-[LIVMAG]-x(1,2)-
                         [LIVM]-G-S
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.82
            ExPASy - ENZYME nomenclature database: 3.2.1.82
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.82
            BRENDA, the Enzyme Database: 3.2.1.82
///
ENTRY       EC 3.2.1.83
NAME        Kappa-carrageenase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     kappa-Carrageenan 4-beta-D-glycanohydrolase
REACTION    Hydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate
            and 3,6-anhydro-D-galactose in various carrageenans
SUBSTRATE   kappa-Carrageenan
            H2O
PRODUCT     3-O-(3,6-Anhydro-alpha-D-galactopyranosyl)-D-galactose 4-O-sulfate
COMMENT     Dominant products are the oligomers [3-O-(3,6-anhydro-alpha-
            D-galactopyranosyl)-D-galactose 4-O-sulfate]1-4.
MOTIF       PS: PS01034  E-[LIV]-D-[LIVF]-x(0,1)-E-x(2)-[GQ]-[KRNF]-x-[PSTA]
STRUCTURES  PDB: 1DYP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.83
            ExPASy - ENZYME nomenclature database: 3.2.1.83
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.83
            BRENDA, the Enzyme Database: 3.2.1.83
            SCOP (Structural Classification of Proteins): 3.2.1.83
///
ENTRY       EC 3.2.1.84
NAME        Glucan 1,3-alpha-glucosidase
            Exo-1,3-alpha-glucanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-alpha-D-Glucan 3-glucohydrolase
REACTION    Hydrolysis of terminal 1,3-alpha-D-glucosidic links in
            1,3-alpha-D-glucans
SUBSTRATE   1,3-alpha-D-Glucan
            H2O
PRODUCT     D-Glucose
COMMENT     Does not act on nigeran.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.84
            ExPASy - ENZYME nomenclature database: 3.2.1.84
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.84
            BRENDA, the Enzyme Database: 3.2.1.84
///
ENTRY       EC 3.2.1.85
NAME        6-Phospho-beta-galactosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     6-Phospho-beta-D-galactoside 6-phosphogalactohydrolase
REACTION    a 6-Phospho-beta-D-galactoside + H2O = an Alcohol +
            D-Galactose 6-phosphate
SUBSTRATE   6-Phospho-beta-D-galactoside
            Phospho-beta-D-glucoside
            H2O
PRODUCT     Alcohol
            D-Galactose 6-phosphate
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       SAU: SA1991(lacG)
            SAV: SAV2175(lacG)
            SPY: SPy1916(lacG)
            SPN: SP0477 SP1184
            SPR: spr0424(lacG) spr1069(lacG)
            CAC: CAC2963(lacG)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
STRUCTURES  PDB: 4PBG  3PBG  2PBG  1PBG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.85
            ExPASy - ENZYME nomenclature database: 3.2.1.85
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.85
            BRENDA, the Enzyme Database: 3.2.1.85
            SCOP (Structural Classification of Proteins): 3.2.1.85
///
ENTRY       EC 3.2.1.86
NAME        6-Phospho-beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     6-Phospho-beta-D-glucosyl-(1,4)-D-gluxose glucohydrolase
REACTION    6-Phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O = D-Glucose +
            D-Glucose 6-phosphate
SUBSTRATE   6-Phospho-beta-D-glucosyl-(1,4)-D-glucose
            Phospho-beta-D-glucoside
            H2O
PRODUCT     D-Glucose
            D-Glucose 6-phosphate
COMMENT     Also hydrolyses several other phospho-beta-D-glucosides, but not
            their non-phosphorylated forms.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       ECO: b1734(celF) b2716(ascB) b2901(bglA) b3681(glvG) b3721(bglB)
            ECE: Z2764(celF) Z4024(ascB) Z4239(bglA) Z5177
            ECS: ECs2440 ECs3572 ECs3773 ECs4622
            YPE: YPO0166 YPO1254(bglA)
            VCH: VC1284 VC1558
            BSU: BG11203(bglA) BG11350(licH)
            BHA: BH0183(licH) BH0912
            SAU: SA0256(bglA)
            SAV: SAV0259(bglA)
            LLA: L121426(yrcA) L22116(bglA)
            SPY: SPy0574(bglA)
            SPN: SP0303 SP0578
            SPR: spr0276(bglA) spr0506(bglH)
            CAC: CAC0743 CAC1408 CAC3426(glvG)
            TMA: TM1281
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
            PS: PS01324  P-x-[SA]-x-[LIVMFY](2)-[QN]-x(2)-N-P-x(4)-[TA]-x(9,10)-
                         [KRD]-x-[LIV]-[GN]-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.86
            ExPASy - ENZYME nomenclature database: 3.2.1.86
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.86
            BRENDA, the Enzyme Database: 3.2.1.86
///
ENTRY       EC 3.2.1.87
NAME        Capsular-polysaccharide endo-1,3-alpha-galactosidase
            Polysaccharide depolymerase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Aerobacter-capsular-polysaccharide galactohydrolase
REACTION    Random hydrolysis of 1,3-alpha-D-galactosidic linkages in
            Aerobacter aerogenes capsular polysaccharide
SUBSTRATE   Aerobacter aerogenes capsular polysaccharide
            H2O
COMMENT     Hydolyses the galactosyl-alpha-1,3-D-galactose linkages only in
            the complex substrate, bringing about depolyymerization.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.87
            ExPASy - ENZYME nomenclature database: 3.2.1.87
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.87
            BRENDA, the Enzyme Database: 3.2.1.87
///
ENTRY       EC 3.2.1.88
NAME        beta-L-Arabinosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-L-Arabinoside arabinohydrolase
REACTION    a beta-L-Arabinoside + H2O = an Alcohol + L-Arabinose
SUBSTRATE   beta-L-Arabinoside
            H2O
PRODUCT     Alcohol
            L-Arabinose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.88
            ExPASy - ENZYME nomenclature database: 3.2.1.88
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.88
            BRENDA, the Enzyme Database: 3.2.1.88
///
ENTRY       EC 3.2.1.89
NAME        Arabinogalactan endo-1,4-beta-galactosidase
            Endo-1,4-beta-galactanase
            Galactanase
            Arabinogalactanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Arabinogalactan 4-beta-D-galactohydrolase
REACTION    Endohydrolysis of 1,4-D-galactosidic linkages in arabinogalactans
SUBSTRATE   Arabinogalactan
            H2O
GENES       TMA: TM1201
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.89
            ExPASy - ENZYME nomenclature database: 3.2.1.89
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.89
            BRENDA, the Enzyme Database: 3.2.1.89
///
ENTRY       EC 3.2.1.90
NAME        Arabinogalactan endo-1,3-beta-galactosidase
            Endo-1,3-beta-galactanase
            Galactanase
            Arabinogalactanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Arabinogalactan 3-beta-D-galactanohydrolase
REACTION    Endohydrolysis of 1,3-D-galactosidic linkages in arabinogalactans
SUBSTRATE   Arabinogalactan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.90
            ExPASy - ENZYME nomenclature database: 3.2.1.90
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.90
            BRENDA, the Enzyme Database: 3.2.1.90
///
ENTRY       EC 3.2.1.91
NAME        Cellulose 1,4-beta-cellobiosidase
            Exo-cellobiohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-D-Glucan cellobiohydrolase
REACTION    Hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose and
            cellotetraose, releasing cellobiose from the non-reducing ends of
            the chains
SUBSTRATE   Cellulose
            Cellotetraose
            H2O
PRODUCT     Cellobiose
            Cellulose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
MOTIF       PS: PS00561  W-N-[STAGR]-[STDN]-[LIVM]-x(2)-[GST]-x-[GST]-x(2)-
                         [LIVMFT]-[GA]
            PS: PS00562  C-G-G-x(4,7)-G-x(3)-C-x(5)-C-x(3,5)-[NHG]-x-[FYWM]-
                         x(2)-Q-C
            PS: PS00591  [GTA]-x(2)-[LIVN]-x-[IVMF]-[ST]-E-[LIY]-[DN]-[LIVMF]
            PS: PS00655  V-x-Y-x(2)-P-x-R-D-C-[GSAF]-x(2)-[GSA](2)-x-G
            PS: PS00656  [LIVMYA]-[LIVA]-[LIVT]-[LIV]-E-P-D-[SAL]-[LI]-[PSAG]
            PS: PS00659  [LIV]-[LIVMFYWGA](2)-[DNEQG]-[LIVMGST]-x-N-E-[PV]-
                         [RHDNSTLIVFY]
            PS: PS01072  [LVFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[FYWPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,6)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
STRUCTURES  PDB: 6CEL  1FH7  8CEL  1EXG  1EXP  1EXH  5CEL  4CEL  3CEL  1AZ6  
                 1AZH  1AZJ  1AZK  1BVW  1CB2  1CBH  1CEL  1DY4  1EG8  1EGB  
                 1EGN  7CEL  1QK2  3CBH  1FH8  1FH9  1FHD  1QJW  1QK0  2BVW  
                 2CBH  2CEL  2EXO  2HIS  2XYL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.91
            ExPASy - ENZYME nomenclature database: 3.2.1.91
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.91
            BRENDA, the Enzyme Database: 3.2.1.91
            SCOP (Structural Classification of Proteins): 3.2.1.91
///
ENTRY       EC 3.2.1.92
NAME        Peptidoglycan beta-N-acetylmuramidase
            Exo-beta-N-acetylmuramidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Peptidoglycan beta-N-acetylmuramoylexohydrolase
REACTION    Hydrolysis of terminal, non-reducing N-acetylmuramic residues
SUBSTRATE   Peptidoglycan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.92
            ExPASy - ENZYME nomenclature database: 3.2.1.92
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.92
            BRENDA, the Enzyme Database: 3.2.1.92
///
ENTRY       EC 3.2.1.93
NAME        alpha,alpha-Phosphotrehalase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha,alpha-Trehalose-6-phosphate phosphoglucohydrolase
REACTION    alpha,alpha'-Trehalose 6-phosphate + H2O = D-Glucose +
            D-Glucose 6-phosphate
SUBSTRATE   alpha,alpha'-Trehalose 6-phosphate
            H2O
PRODUCT     D-Glucose
            D-Glucose 6-phosphate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b4239(treC)
            ECE: Z5849(treC)
            ECS: ECs5216
            YPE: YPO3696(treC)
            VCH: VC0911
            BSU: BG11010(treA)
            BHA: BH0872(treA)
            SAU: SA0433
            SAV: SAV0462(treA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.93
            ExPASy - ENZYME nomenclature database: 3.2.1.93
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.93
            BRENDA, the Enzyme Database: 3.2.1.93
///
ENTRY       EC 3.2.1.94
NAME        Glucan 1,6-alpha-isomaltosidase
            Exo-isomaltohydrolase
            Isomalto-dextranase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-alpha-D-Glucan isomaltohydrolase
REACTION    Hydrolysis of 1,6-alpha-D-glucosidic linkages in polysaccharides
            so as to remove successive isomaltose units from the non-reducing
            ends of the chains
SUBSTRATE   Polysaccharide
            H2O
PRODUCT     Isomaltose
COMMENT     Optimum activity is on those 1,6-alpha-D-glucans coantaining 6, 7
            and 8 glucose units; those containing 3, 4 and 5 glucose units
            are hydolysed at slower rate.
MOTIF       PS: PS00512  G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-D-x-W-x(3,4)-R-
                         [DNSF]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.94
            ExPASy - ENZYME nomenclature database: 3.2.1.94
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.94
            BRENDA, the Enzyme Database: 3.2.1.94
///
ENTRY       EC 3.2.1.95
NAME        Dextran 1,6-alpha-isomaltotriosidase
            Exo-isomaltotriohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-alpha-D-Glucan isomaltotriohydrolase
REACTION    Hydrolysis of 1,6-alpha-D-glucosidic linkages in dextrans, so as
            to remove successive isomaltotriose units from the non-reducing
            ends of the chains
SUBSTRATE   Dextran
            H2O
PRODUCT     Isomaltotriose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.95
            ExPASy - ENZYME nomenclature database: 3.2.1.95
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.95
            BRENDA, the Enzyme Database: 3.2.1.95
///
ENTRY       EC 3.2.1.96
NAME        Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase
            N,N'-Diacetylchitobiosyl beta-N-acetylglucosaminidase
            Endo-beta-N-acetylglucosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-
            -asparagine 1,4-N-acetyl-beta-glucosaminohydrolase
REACTION    Endohydroylsis of the N,N'-diacetylchitobiosyl unit in
            high-mannose glycopeptides and glycoproteins containing the
            -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue
            remains attached to the protein; the rest of the oligosaccharide
            is released intact
SUBSTRATE   High-mannose glycopeptide containing -{Man(GlcNAc)2}Asn-
            H2O
PRODUCT     Oligosaccharide(terminal -ManGlcNAc)
            N-Acetyl-D-glucosamine
COMMENT     A group of related enzymes.
PATHWAY     PATH: MAP00511  Glycoprotein degradation
GENES       SAU: SA0905(atl)
            SAV: SAV1039(atl)
            SPN: SP0965
            SPR: spr0867(lytB)
MOTIF       PS: PS01095  [LIVMFY]-[DN]-G-[LIVMF]-[DN]-[LIVMF]-[DN]-x-E
STRUCTURES  PDB: 1EOM  1C93  1EDT  1C91  1C92  1EOK  1C90  2EBN  1C3F  1C8X  
                 1C8Y  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.96
            ExPASy - ENZYME nomenclature database: 3.2.1.96
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.96
            BRENDA, the Enzyme Database: 3.2.1.96
            SCOP (Structural Classification of Proteins): 3.2.1.96
///
ENTRY       EC 3.2.1.97
NAME        Glycopeptide alpha-N-acetylgalactosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     D-Galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-
            $galactosaminohydrolase
REACTION    Hydrolysis of terminal D-galactosyl-N-acetyl-alpha-D-
            $galactosaminidic residues from a variety of glycopeptides and
            glycoprotein
SUBSTRATE   Glycopeptide
            Glycoprotein
            H2O
PRODUCT     D-Galactosyl-N-acetyl-alpha-D-galactosaminide
COMMENT     The glycone may be serine or threonine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.97
            ExPASy - ENZYME nomenclature database: 3.2.1.97
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.97
            BRENDA, the Enzyme Database: 3.2.1.97
///
ENTRY       EC 3.2.1.98
NAME        Glucan 1,4-alpha-maltohexaosidase
            Exo-maltohexaohydrolase
            Maltohexaose-producing amylase
            G6-amylase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan maltohexaohydrolase
REACTION    Hydrolysis of 1,4-alpha-D-glucosidic linkages in amylaceous
            polysaccharides so as to remove successive maltohexaose residues
            from the non-reducing cahin ends
SUBSTRATE   Amylaceous polysaccharide
            H2O
PRODUCT     Maltohexaose
COMMENT     cf. EC 3.2.1.3, Glucan 1,4-alpha-D-glucosidase, which removes
            successive glucose residues; EC 3.2.1.2, beta-amylase, which
            removes successive maltose residues; EC 3.2.1.116, which
            removes successive maltotriose units and EC 3.2.1.60, glucan
            1,4-alpha-maltotetraohydrolase, which removes successive
            maltotetraose residues.  The products have the
            alpha-configuration.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.98
            ExPASy - ENZYME nomenclature database: 3.2.1.98
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.98
            BRENDA, the Enzyme Database: 3.2.1.98
///
ENTRY       EC 3.2.1.99
NAME        Arabinan endo-1,5-alpha-L-arabinosidase
            Endo-1,5-alpha-L-arabinanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,5-alpha-L-Arabinan 1,5-alpha-L-arabinanohydrolase
REACTION    Endohydrolysis of 1,5-alpha-arabinofuranosidic linkages in
            2,5-arabinans
SUBSTRATE   2,5-Arabinan
            H2O
COMMENT     Also acts on beet arabinan, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.99
            ExPASy - ENZYME nomenclature database: 3.2.1.99
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.99
            BRENDA, the Enzyme Database: 3.2.1.99
///
ENTRY       EC 3.2.1.100
NAME        Mannan 1,4-beta-mannobiosidase
            Exo-1,4-beta-mannobiohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-beta-D-Mannan mannobiohydrolase
REACTION    Hydrolysis of 1,4-beta-D-manosidic linkages in 1,4-beta-D-mannans,
            so as to remove successive mannobiose residues from the
            non-reducing chain ends
SUBSTRATE   1,4-beta-D-Mannan
            H2O
PRODUCT     Mannobiose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.100
            ExPASy - ENZYME nomenclature database: 3.2.1.100
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.100
            BRENDA, the Enzyme Database: 3.2.1.100
///
ENTRY       EC 3.2.1.101
NAME        Mannan endo-1,6-beta-mannosidase
            Endo-1,6-beta-mannanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-beta-D-Mannan mannanohydrolase
REACTION    Random hydrolysis of 1,6-beta-mannosidic linkages in unbranched
            1,6-mannans
SUBSTRATE   1,6-Mannan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.101
            ExPASy - ENZYME nomenclature database: 3.2.1.101
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.101
            BRENDA, the Enzyme Database: 3.2.1.101
///
ENTRY       EC 3.2.1.102
NAME        Blood-group-substance endo-1,4-beta-galactosidase
            Endo-beta-galactosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Blood-group-substance 1,4-beta-D-galactanohydrolase
REACTION    Endohydrolysis of 1,4-beta-D-galactosidic linkages in blood group
            A and B substances
SUBSTRATE   Blood group A substance
            Blood group B substance
            H2O
COMMENT     Hydrolyses the 1,4-beta-D-galactosyl linkages adjacent to a
            1,3-alpha-D-galactosyl or N-acetylgalactosaminyl residues and a
            1,2-alpha-D-fucosyl residue.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.102
            ExPASy - ENZYME nomenclature database: 3.2.1.102
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.102
            BRENDA, the Enzyme Database: 3.2.1.102
///
ENTRY       EC 3.2.1.103
NAME        Keratan-sulfate endo-1,4-beta-galactosidase
            Endo-beta-galactosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Keratan-sulfate 1,4-beta-D-galactanoylhydrolase
REACTION    Endohydrolysis of 1,4-beta-galactosidic linkages in keratan
            sulfate
SUBSTRATE   Keratan sulfate
            H2O
COMMENT     Hydrolyses the 1,4-beta-D-galctosyl linkages adjacent to
            1,3-alpha-D-N-acetyl-glucosaminyl residues. Also acts on some
            non-sulfated oligosaccharides, but only acts on blood group
            substances when the 1,2-linked fucosyl residues have been
            removed (cf. EC 3.2.1.102).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.103
            ExPASy - ENZYME nomenclature database: 3.2.1.103
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.103
            BRENDA, the Enzyme Database: 3.2.1.103
///
ENTRY       EC 3.2.1.104
NAME        Steryl-beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Cholesteryl-beta-D-glucoside glucohydrolase
REACTION    Cholesteryl-beta-D-glucoside + H2O = Cholesterol + D-Glucose
SUBSTRATE   Cholesteryl-beta-D-glucoside
            H2O
PRODUCT     Cholesterol
            D-Glucose
COMMENT     Acts on glucosides of cholesterol and sitosterol, but not of some
            related sterols such as coprostanol.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.104
            ExPASy - ENZYME nomenclature database: 3.2.1.104
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.104
            BRENDA, the Enzyme Database: 3.2.1.104
///
ENTRY       EC 3.2.1.105
NAME        Strictosidine beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Strictosidine beta-D-glucohydrolase
REACTION    Strictosidine + H2O = Strictosidine aglycone + D-Glucose
SUBSTRATE   Strictosidine
            H2O
PRODUCT     Strictosidine aglycone
            D-Glucose
COMMENT     Does not act on a number of closely related glycosides.
            Strictosidine is a precursor of indole alkaloids.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.105
            ExPASy - ENZYME nomenclature database: 3.2.1.105
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.105
            BRENDA, the Enzyme Database: 3.2.1.105
///
ENTRY       EC 3.2.1.106
NAME        Mannosyl-oligosaccharide glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Mannosyl-oligosaccharide glucohydrolase
REACTION    Exohydrolsis of the non-reducing terminal glucose residues in the
            mannosyl-oligosaccharide Glc3Man9GlcNAc2
SUBSTRATE   Mannosyl-oligosaccharide Glc3Man9GlcNAc2
            H2O
PRODUCT     D-Glucose
COMMENT     Also acts, more slowly, on the corresponding glycolipids and
            glycopeptides.  Involved in the formation of high-mannose and
            complex glycoproteins.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YGL027C(CWH41)
            SPO: SPAC6G10.09(spac6g10.09)
            HSA: 7841(GCS1)
DISEASE     MIM: 601336  Glucosidase I
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.106
            ExPASy - ENZYME nomenclature database: 3.2.1.106
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.106
            BRENDA, the Enzyme Database: 3.2.1.106
///
ENTRY       EC 3.2.1.107
NAME        Protein-glucosylgalactosylhydroxylysine glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine
            $ glucohydrolase
REACTION    Protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine +
            H2O = D-Glucose + Protein beta-D-galactosyl-L-hydroxylysine
SUBSTRATE   Protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine
            H2O
PRODUCT     D-Glucose
            Protein beta-D-galactosyl-L-hydroxylysine
COMMENT     Requires free, positively charged epsilon-amino group of
            hydroxylysine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.107
            ExPASy - ENZYME nomenclature database: 3.2.1.107
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.107
            BRENDA, the Enzyme Database: 3.2.1.107
///
ENTRY       EC 3.2.1.108
NAME        Lactase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Lactose galactohydrolase
REACTION    Lactose + H2O = D-Glucose + D-Galactose
SUBSTRATE   Lactose
            H2O
PRODUCT     D-Glucose
            D-Galactose
COMMENT     The enzyme from intestinal mucosa is isolated as a complex which
            also catalyses the reaciton of EC 3.2.1.62.  cf. EC 3.2.1.23.
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       CEL: E02H9.5
            HSA: 3938(LCT)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.108
            ExPASy - ENZYME nomenclature database: 3.2.1.108
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.108
            BRENDA, the Enzyme Database: 3.2.1.108
///
ENTRY       EC 3.2.1.109
NAME        Endogalactosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Galactosaminoglycan glycanohydrolase
REACTION    Endohydrolysis of 1,4-alpha-D-galactosaminidic linkages in
            poly(D-galactosamine)
SUBSTRATE   Poly(D-galactosamine)
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.109
            ExPASy - ENZYME nomenclature database: 3.2.1.109
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.109
            BRENDA, the Enzyme Database: 3.2.1.109
///
ENTRY       EC 3.2.1.110
NAME        Mucinaminylserine mucinaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     D-Galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine
            $ mucinaminohydrolase
REACTION    D-Galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O =
            D-Galactosyl-3-N-acetyl-beta-D-galactosamine + L-Serine
SUBSTRATE   D-Galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine
            H2O
PRODUCT     D-Galactosyl-3-N-acetyl-beta-D-galactosamine
            L-Serine
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.110
            ExPASy - ENZYME nomenclature database: 3.2.1.110
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.110
            BRENDA, the Enzyme Database: 3.2.1.110
///
ENTRY       EC 3.2.1.111
NAME        1,3-alpha-L-Fucosidase
            Almond emulsin fucosidase I
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     3-alpha-D-Fucosyl-N-acetylglucosaminyl-glycoprotein
            $ fucohydrolase
REACTION    Hydrolysis of 1,3-linkages between alpha-L-fucose and N-acetyl-
            glucosamine residues in glycoproteins
SUBSTRATE   Glycoprotein
            H2O
COMMENT     Not identical with EC 3.2.1.63.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.111
            ExPASy - ENZYME nomenclature database: 3.2.1.111
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.111
            BRENDA, the Enzyme Database: 3.2.1.111
///
ENTRY       EC 3.2.1.112
NAME        2-Deoxyglucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     2-Deoxy-alpha-D-glucoside deoxyglucohydrolase
REACTION    a 2-Deoxy-alpha-D-glucoside + H2O = an Alcohol + 2-Deoxy-D-glucose
SUBSTRATE   2-Deoxy-alpha-D-glucoside
            H2O
PRODUCT     Alcohol
            2-Deoxy-D-glucose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.112
            ExPASy - ENZYME nomenclature database: 3.2.1.112
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.112
            BRENDA, the Enzyme Database: 3.2.1.112
///
ENTRY       EC 3.2.1.113
NAME        Mannosyl-oligosaccharide 1,2-alpha-mannosidase
            Mannosidase 1A
            Mannosidase 1B
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,2-alpha-Mannosyl-oligosaccharide alpha-D-mannohydrolase
REACTION    Hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in
            the oligo-mannose oligosaccharide Man9(GlcNAc)2
SUBSTRATE   Man9(GlcNAc)2
            H2O
PRODUCT     alpha-D-Mannose
COMMENT     Involved in the synthesis of glycoproteins.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       SCE: YJR131W(MNS1)
            DME: CG17809(alpha-Man-I)
            HSA: 4121(MAN1A1)
STRUCTURES  PDB: 1DL2  1FMI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.113
            ExPASy - ENZYME nomenclature database: 3.2.1.113
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.113
            BRENDA, the Enzyme Database: 3.2.1.113
            SCOP (Structural Classification of Proteins): 3.2.1.113
///
ENTRY       EC 3.2.1.114
NAME        Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
            Mannosidase II
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,3-(1,6-)-Mannosyl-oligosaccharide alpha-D-mannohydrolase
REACTION    Hydrolysis of the terminal 1,3- and 1,6- linked alpha-D-mannose
            residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.
SUBSTRATE   Man5(GlcNAc)3
PRODUCT     Mannose
COMMENT     Involved in the synthesis of glycoproteins.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
GENES       CEL: F58H1.1
            DME: CG18474 alpha-Man-II
            HSA: 4122(MAN2A2) 4124(MAN2A1)
DISEASE     MIM: 154582  Mannosidase, alpha, class 2A, member 1
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.114
            ExPASy - ENZYME nomenclature database: 3.2.1.114
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.114
            BRENDA, the Enzyme Database: 3.2.1.114
///
ENTRY       EC 3.2.1.115
NAME        Branched-dextran exo-1,2-alpha-glucosidase
            Dextran alpha-(1,2)-debranching enzyme
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,2-alpha-D-Glucosyl-branched-dextran 2-glucohydrolase
REACTION    Hydrolysis of 1,2-alpha-D-Glucosidic linkages at the branched
            points of dextrans and related polysaccharides, producing free
            D-glucose
SUBSTRATE   Dextran
            H2O
COMMENT     Does not hydrolyse disaccharides or oligosaccharides containing
            linear 1,2-alpha-glucosidic linkage.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.115
            ExPASy - ENZYME nomenclature database: 3.2.1.115
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.115
            BRENDA, the Enzyme Database: 3.2.1.115
///
ENTRY       EC 3.2.1.116
NAME        Glucan 1,4-alpha-maltotriohydrolase
            Exo-maltotriohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan maltotriohydrolase
REACTION    Hydrolysis of 1,4-alpha-D-Glucosidic linkages in amylaceous
            polysaccharides so as to remove successive maltotriose residues
            from the non-reducing chain ends
SUBSTRATE   Amylaceous polysaccharide
            H2O
PRODUCT     Maltotriose
COMMENT     cf. EC 3.2.1.2, 3.2.1.60, and 3.2.1.98. The products have the
            alpha-configuration.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.116
            ExPASy - ENZYME nomenclature database: 3.2.1.116
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.116
            BRENDA, the Enzyme Database: 3.2.1.116
///
ENTRY       EC 3.2.1.117
NAME        Amygdalin beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Amygdalin beta-D-glucohydrolase
REACTION    (R)-Amygdalin + H2O = (R)-Prunasin + D-Glucose
SUBSTRATE   (R)-Amygdalin
            H2O
PRODUCT     (R)-Prunasin
            D-Glucose
COMMENT     Highly specific; does not act on prunasin, linamarin, gentiobiose
            or cellobiose (cf. EC 3.2.1.21).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.117
            ExPASy - ENZYME nomenclature database: 3.2.1.117
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.117
            BRENDA, the Enzyme Database: 3.2.1.117
///
ENTRY       EC 3.2.1.118
NAME        Prunasin beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Prunasin beta-D-glucohydrolase
REACTION    (R)-Prunasin + H2O = Mandelonitrile + D-Glucose
SUBSTRATE   (R)-Prunasin
            H2O
PRODUCT     Mandelonitrile
            D-Glucose
COMMENT     Highly specific; does not act on amygdalin, linamarin or
            gentiobiose (cf. EC 3.2.1.21).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.118
            ExPASy - ENZYME nomenclature database: 3.2.1.118
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.118
            BRENDA, the Enzyme Database: 3.2.1.118
///
ENTRY       EC 3.2.1.119
NAME        Vicianin beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     (R)-Vicianin beta-D-glucohydrolase
REACTION    (R)-Vicianin + H2O = Mandelonitrile + Vicianose
SUBSTRATE   (R)-Vicianin
            H2O
PRODUCT     Mandelonitrile
            Vicianose
COMMENT     Also hydrolyses, more slowly, (R)-amygdalin and (R)-prunasin, but
            not gentiobiose, linamarin or cellobiose.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.119
            ExPASy - ENZYME nomenclature database: 3.2.1.119
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.119
            BRENDA, the Enzyme Database: 3.2.1.119
///
ENTRY       EC 3.2.1.120
NAME        Oligoxyloglucan beta-glycosidase
            Isoprimeverose-producing oligoxyloglucan hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Oligoxyloglucan xyloglucohydrolase
REACTION    Hydrolysis of 1,4-beta-D-glucosidic links in oligoxyloglucans
            so as to remove successive isoprimeverose
            [i.e. alpha-xylo-1,6-beta-D-glucosyl-] residues from the
            non-reducing chain ends.
SUBSTRATE   Oligoxyloglucan
            H2O
PRODUCT     alpha-Xylo-1,6-beta-D-glucose
            Oligoxyloglucan
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.120
            ExPASy - ENZYME nomenclature database: 3.2.1.120
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.120
            BRENDA, the Enzyme Database: 3.2.1.120
///
ENTRY       EC 3.2.1.121
NAME        Polymannuronate hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(mannuronide) mannuronohydrolase
REACTION    Endohydrolysis of the D-mannuronide linkages of polymannuronate.
SUBSTRATE   Polymannuronate
            H2O
PRODUCT     Polymannuronate
COMMENT     Does not act on alginic acid, which is a copolymer of
            polymannuronate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.121
            ExPASy - ENZYME nomenclature database: 3.2.1.121
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.121
            BRENDA, the Enzyme Database: 3.2.1.121
///
ENTRY       EC 3.2.1.122
NAME        Maltose-6'-phosphate glucosidase
            Phospho-alpha-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Maltose-6'-phosphate 6-phosphoglucohydrolase
REACTION    Maltose 6'-phosphate + H2O = D-Glucose 6-phosphate + D-Glucose
SUBSTRATE   Maltose 6'-phosphate
            H2O
PRODUCT     D-Glucose 6-phosphate
            D-Glucose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       BSU: BG11839(glvA)
            CAC: CAC0533(glvA)
MOTIF       PS: PS01324  P-x-[SA]-x-[LIVMFY](2)-[QN]-x(2)-N-P-x(4)-[TA]-x(9,10)-
                         [KRD]-x-[LIV]-[GN]-x-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.122
            ExPASy - ENZYME nomenclature database: 3.2.1.122
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.122
            BRENDA, the Enzyme Database: 3.2.1.122
///
ENTRY       EC 3.2.1.123
NAME        Endoglycosylceramidase
            Endoglycoceramidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Oligoglycosylglucosylceramide glycohydrolase
REACTION    Oligoglycosylglucosylceramide + H2O = Oligoglycosylglucose +
            Ceramide
SUBSTRATE   Oligoglycosylglucosylceramide
            H2O
            Acidic glycosphingolipid
            Neutral glycosphingolipid
            Glycosphingolipid
PRODUCT     Oligoglycosylglucose
            Ceramide
            Oligosaccharide
COMMENT     An enzyme from Rhodococcus sp. which degrades various acidic
            and neutral glycosphingolipids to oligosaccharides and ceramides,
            by cleaving a glucosyl bond. Does not act on
            monoglycosylceramides (cf. EC 3.2.1.62).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.123
            ExPASy - ENZYME nomenclature database: 3.2.1.123
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.123
            BRENDA, the Enzyme Database: 3.2.1.123
///
ENTRY       EC 3.2.1.124
NAME        3-Deoxy-2-octulosonidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase
REACTION    Endohydrolysis of the beta-ketopyranosidic linkages of
            3-deoxy-D-manno-2-octulosonate in capsular polysaccharides
SUBSTRATE   3-Deoxy-D-manno-2-octulosonate
            H2O
COMMENT     The enzyme from a vacteriophage catalyses the depolymerization of
            capsular polysaccharides containing 3-deoxy-2-octulosonide in the
            cell wall of Escherichia coli.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.124
            ExPASy - ENZYME nomenclature database: 3.2.1.124
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.124
            BRENDA, the Enzyme Database: 3.2.1.124
///
ENTRY       EC 3.2.1.125
NAME        Raucaffricine beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Raucaffricine beta-D-glucohydrolase
REACTION    Raucaffricine + H2O = Vomilenine + D-Glucose
SUBSTRATE   Raucaffricine
            H2O
PRODUCT     Vomilenine
            D-Glucose
COMMENT     Highly specific; some other ajmalan glucoside alkaloids are
            hydrolysed, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.125
            ExPASy - ENZYME nomenclature database: 3.2.1.125
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.125
            BRENDA, the Enzyme Database: 3.2.1.125
///
ENTRY       EC 3.2.1.126
NAME        Coniferin beta-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Coniferin beta-D-glucosidase
REACTION    Coniferin + H2O = Coniferol + D-Glucose
SUBSTRATE   Coniferin
            H2O
            Syringin
            4-Cinnamyl alcohol beta-glucoside
PRODUCT     Coniferol
            D-Glucose
            Sinapyl alcohol
COMMENT     Also hydrolyses syringin, 4-cinnamyl alcohol beta-glucoside, and,
            more slowly, some other aryl beta-glycosides.  A plant cell-wall
            enzyme involved in the biosynthesis of lignin.
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.126
            ExPASy - ENZYME nomenclature database: 3.2.1.126
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.126
            BRENDA, the Enzyme Database: 3.2.1.126
///
ENTRY       EC 3.2.1.127
NAME        1,6-alpha-L-Fucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,6-L-Fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase
REACTION    Hydrolysis of 1,6-linkages between alpha-D-fucose and
            N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G
            glycopeptide and fucosyl-asialo-agalacto-fetuin
SUBSTRATE   Glycopeptide
            Immunoglobulin G glycopeptide
            Fucosyl-asialo-agalacto-fetuin
COMMENT     The enzyme from Aspergillus niger does not act on 1,2-, 1,3-, or
            1,4-L-fuxosyl linkage.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.127
            ExPASy - ENZYME nomenclature database: 3.2.1.127
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.127
            BRENDA, the Enzyme Database: 3.2.1.127
///
ENTRY       EC 3.2.1.128
NAME        Glycyrrhizinate beta-glucuronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycyrrhizinate glucuronosylhydrolase
REACTION    Glycyrrhizinate + H2O = 1,2-beta-D-Glucuronosyl-D-glucuronate +
            Glycyrrhetinate
SUBSTRATE   Glycyrrhizinate
            H2O
PRODUCT     1,2-beta-D-Glucuronosyl-D-glucuronate
            Glycyrrhetinate
COMMENT     The enzyme from Aspergillus niger is specific for the hydrolysis
            of the triterpenoids glyucoside glycyrrhizinate from roots of
            Glycyrrhiza sp.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.128
            ExPASy - ENZYME nomenclature database: 3.2.1.128
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.128
            BRENDA, the Enzyme Database: 3.2.1.128
///
ENTRY       EC 3.2.1.129
NAME        Endo-alpha-sialidase
            Endo-N-acetylneuraminidase
            Endoneuraminidase
            Poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Poly(sialoside) alpha-2,8-sialosylhydrolase
REACTION    Endohydrolysis of alpha-2,8-sialosyl linkages in oligo or
            poly(sialic) acids.
SUBSTRATE   Poly(sialoside)
            H2O
COMMENT     An exo-alpha-sialidase activity is listed as EC 3.2.1.18.  See
            also EC 3.2.1.138.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.129
            ExPASy - ENZYME nomenclature database: 3.2.1.129
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.129
            BRENDA, the Enzyme Database: 3.2.1.129
///
ENTRY       EC 3.2.1.130
NAME        Glycoprotein endo-alpha-1,2-mannosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycoprotein glucosylmannohydrolase
REACTION    Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit
            from the GlcMan9(GlcNAc)2 oligosaccharide component of the
            glycoprotein produced in the Golgi membrane
SUBSTRATE   GlcMan9(GlcNAc)2
            H2O
PRODUCT     alpha-D-Glucosyl-(1,3)-D-mannose
COMMENT     Involved in the synthesis of glycoproteins.
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.130
            ExPASy - ENZYME nomenclature database: 3.2.1.130
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.130
            BRENDA, the Enzyme Database: 3.2.1.130
///
ENTRY       EC 3.2.1.131
NAME        Xylan alpha-1,2-glucuronosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase
REACTION    Hydrolysis of alpha-D-1,2-(4-O-methyl)glucuronosyl links in the
            main chain of hardwood xylans
SUBSTRATE   Xylan
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.131
            ExPASy - ENZYME nomenclature database: 3.2.1.131
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.131
            BRENDA, the Enzyme Database: 3.2.1.131
///
ENTRY       EC 3.2.1.132
NAME        Chitosanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Chitosan N-acetylglucosaminohydrolase
REACTION    Endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine
            and D-glucosamine residues in a partly acetylated chitosan
SUBSTRATE   Chitosan
            H2O
COMMENT     Acts only on polymers with 30% to 60% acetylation.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       BSU: BG11923(csn)
STRUCTURES  PDB: 1QGI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.132
            ExPASy - ENZYME nomenclature database: 3.2.1.132
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.132
            BRENDA, the Enzyme Database: 3.2.1.132
            SCOP (Structural Classification of Proteins): 3.2.1.132
///
ENTRY       EC 3.2.1.133
NAME        Glucan 1,4-alpha-maltohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan alpha-maltohydrolase
REACTION    Hydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides
            so as to remove successive alpha-maltose units from the non-
            reducing ends of the chains
SUBSTRATE   Glucan
            H2O
PRODUCT     alpha-Maltose
COMMENT     Acts on starch and related polysaccharides and oligosaccharides.
            The product is alpha-maltose; cf. EC 3.2.1.2.
STRUCTURES  PDB: 1QHO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.133
            ExPASy - ENZYME nomenclature database: 3.2.1.133
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.133
            BRENDA, the Enzyme Database: 3.2.1.133
            SCOP (Structural Classification of Proteins): 3.2.1.133
///
ENTRY       EC 3.2.1.134
NAME        Difructose-anhydride synthase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Bis-D-fructose-2',1:2,1'-dianhydride fructohydrolase
REACTION    Bis-D-fructose 2',1:2,1'-dianhydride + H2O = Inulobiose
SUBSTRATE   Bis-D-fructose 2',1:2,1'-dianhydride
            H2O
PRODUCT     Inulobiose
COMMENT     Products difructose anhydride by the reverse reaction of partial
            hydrolysis, forming an alpha-fructosidic linkage.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.134
            ExPASy - ENZYME nomenclature database: 3.2.1.134
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.134
            BRENDA, the Enzyme Database: 3.2.1.134
///
ENTRY       EC 3.2.1.135
NAME        Neopullulanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Pullulan 4-D-glucanohydrolase (panose-forming)
REACTION    Hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)
SUBSTRATE   Pullulan
            H2O
PRODUCT     Panose
COMMENT     cf. EC 3.2.1.41 and 3.2.1.57.
GENES       SPR: spr0948(nplT)
            SYN: sll0842(nplT)
STRUCTURES  PDB: 1JL8  1JIB  1G1Y  1BVZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.135
            ExPASy - ENZYME nomenclature database: 3.2.1.135
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.135
            BRENDA, the Enzyme Database: 3.2.1.135
            SCOP (Structural Classification of Proteins): 3.2.1.135
///
ENTRY       EC 3.2.1.136
NAME        Glucuronoarabinoxylan endo-1,4-beta-xylanase
            Feraxan endoxylanase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase
REACTION    Endohydrolysis of 1,4-beta-D-xylosyl links in some
            glucuronoarabinoxylans
SUBSTRATE   Glucuronoarabinoxylan
            H2O
COMMENT     High activity towards feruloylated arabinoxylans from cereal plant
            cell walls.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.136
            ExPASy - ENZYME nomenclature database: 3.2.1.136
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.136
            BRENDA, the Enzyme Database: 3.2.1.136
///
ENTRY       EC 3.2.1.137
NAME        Mannan exo-1,2-1,6-alpha-mannosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,2-1,6-alpha-D-Mannan D-mannohydrolase
REACTION    Hydrolysis of 1,2-alpha-D- and 1,6-alpha-D- linkages in yeast
            mannan, releasing D-mannose
SUBSTRATE   Mannan
            H2O
PRODUCT     D-Mannose
COMMENT     Mannose residues linked alpha-D-1,3- are also released, very
            slowly.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.137
            ExPASy - ENZYME nomenclature database: 3.2.1.137
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.137
            BRENDA, the Enzyme Database: 3.2.1.137
///
ENTRY       EC 3.2.1.138
NAME        Anhydrosialidase
            Anhydroneuraminidase
            Sialidase L
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Sialglycoconjugate N-acylneuraminylhydrolase
REACTION    Hydrolysis of alpha-sialosyl linkages in N-acetylneuraminic acid
            glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminic acid
SUBSTRATE   N-Acetylneuraminic acid glycoside
            H2O
            N-Glycolylneuraminic acid glycoside
PRODUCT     2,7-Anhydro-alpha-N-acetylneuraminic acid
COMMENT     Also acts on N-glycolylneuraminic acid glycosides.
            cf. EC 3.2.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.138
            ExPASy - ENZYME nomenclature database: 3.2.1.138
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.138
            BRENDA, the Enzyme Database: 3.2.1.138
///
ENTRY       EC 3.2.1.139
NAME        alpha-Glucosiduronase
            alpha-Glucuronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
REACTION    alpha-D-Glucuronoside + H2O = Alcohol + D-Glucuronate
SUBSTRATE   alpha-D-Glucuronoside
            H2O
PRODUCT     Alcohol
            D-Glucuronate
COMMENT     Considerable differences in the specificities of the enzymes from
            different fungi for alpha-D-glucosiduronates have been reported.
GENES       BHA: BH1061
            TMA: TM0055
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.139
            ExPASy - ENZYME nomenclature database: 3.2.1.139
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.139
///
ENTRY       EC 3.2.1.140
NAME        Lacto-N-biosidase
            Oligosaccharide lacto-N-biosylhydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
REACTION    beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc +
            H2O = beta-D-Gal-(1->3)-D-GlcNAc + beta-D-Gal-(1->4)-D-Glc
SUBSTRATE   beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc
            H2O
PRODUCT     beta-D-Gal-(1->3)-D-GlcNAc
            beta-D-Gal-(1->4)-D-Glc
COMMENT     The enzyme from Streptomyces specifically hydrolyses the terminal
            lacto-N-biosyl residue (beta-D-Gal-(1->3)-D-GlcNAc) from the non-
            reducing end of oligosaccharides with the structure beta-D-Gal-
            (1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->R). Lacto-N-hexaose
            (beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->3)-beta-D-
            GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc) is hydrolysed to form first
            lacto-N-tetraose plus lacto-N-biose, with the subsequent formation
            of lactose.
            Oligosaccharides in which the non-reducing terminal Gal or the
            penultimate GlcNAc are replaced by fucose or sialic acid are not
            substrates.
            Asialo GM1 tetraose (beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-beta-
            D-Gal-(1->4)-D-Glc) is hydrolysed very slowly, but lacto-N-
            neotetraose (beta-D-Gal-(1->4)-beta-D-GalNac-(1->3)-beta-D-Gal-
            (1->4)-D-Glc) is not a substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.140
            ExPASy - ENZYME nomenclature database: 3.2.1.140
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.140
///
ENTRY       EC 3.2.1.141
NAME        4-alpha-D-{(1->4)-alpha-D-Glucano}trehalose trehalohydrolase
            Malto-oligosyltrehalose trehalohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
REACTION    Hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-
            {(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and
            alpha-(1->4)-D-glucan
SUBSTRATE   4-alpha-D-(1,4-alpha-D-Glucanosyl)n trehalose
PRODUCT     alpha,alpha-Trehalose
            1,4-alpha-D-Glucan
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.141
            ExPASy - ENZYME nomenclature database: 3.2.1.141
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.141
///
ENTRY       EC 3.2.1.142
NAME        Limit dextrinase
            R-enzyme
            Amylopectin-1,6-glucosidase
            Amylopectin 6-glucanohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycogen/amylopectin alpha/beta-limit dextrin alpha1,6-
            glucanohydrolase
REACTION    Hydrolysis of (1->6)-alpha-D-glucosidic linkages in alpha- and 
            beta-limit Dextrins of amylopectin and glycogen, and in amylopectin
            and pullulan
SUBSTRATE   alpha- and beta-Limit dextrin
            Amylopectin
            Pullulan
            H2O
PRODUCT     Maltose
COMMENT     Plant enzymes with little or no action on glycogen. Action on
            amylopectin is incomplete, but action on alpha-limit dextrins is
            complete. Maltose is the smallest sugar it can release from (1->6)-
            alpha-linkage.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.142
            ExPASy - ENZYME nomenclature database: 3.2.1.142
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.142
///
ENTRY       EC 3.2.1.143
NAME        Poly(ADP-ribose) glycohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
REACTION    Hydrolyses poly(ADPribose) at glycosidic (1"-2') linkage of
            ribose-ribose bond to produce free ADPribose
SUBSTRATE   Poly(ADPribose)
            H2O
PRODUCT     ADPribose
COMMENT     Specific to (1"-2') linkage of ribose-ribose bond of poly(ADP-
            ribose).
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.143
            ExPASy - ENZYME nomenclature database: 3.2.1.143
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.143
///
ENTRY       EC 3.2.1.144
NAME        3-Deoxyoctulosonase
            alpha-Kdo-ase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     3-Deoxyoctulosonyl-lipopolysaccharide hydrolase
REACTION    3-Deoxyoctulosonyl-lipopolysaccharide + H2O = 3-Deoxyoctulosonic
            acid + Lipopolysaccharide
SUBSTRATE   3-Deoxyoctulosonyl-lipopolysaccharide
            H2O
PRODUCT     3-Deoxyoctulosonic acid
            Lipopolysaccharide
COMMENT     Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic 
            acid) from different lipopolysaccharides, including Re-LPS from
            Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-
            O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is
            also a substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.1.144
            ExPASy - ENZYME nomenclature database: 3.2.1.144
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.144
///
ENTRY       EC 3.2.2.1
NAME        Purine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     N-D-Ribosylpurine ribohydrolase
REACTION    an N-D-Ribosylpurine + H2O = a Purine + D-Ribose
SUBSTRATE   N-D-Ribosylpurine
            H2O
PRODUCT     Purine
            D-Ribose
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       PMU: PM1767(iunH)
            MLO: mlr2009
            SSO: SSO0505(iunH-1) SSO2243(iunH-2)
            STO: ST0803
MOTIF       PS: PS01247  D-x-D-[PT]-[GA]-x-D-D-[TAV]-[VI]-A
STRUCTURES  PDB: 2MAS  1EZR  1MAS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.1
            ExPASy - ENZYME nomenclature database: 3.2.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.1
            BRENDA, the Enzyme Database: 3.2.2.1
            SCOP (Structural Classification of Proteins): 3.2.2.1
///
ENTRY       EC 3.2.2.2
NAME        Inosine nucleosidase
            Inosinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Inosine ribohydrolase
REACTION    Inosine + H2O = Hypoxanthine + D-Ribose
SUBSTRATE   Inosine
            H2O
PRODUCT     Hypoxanthine
            D-Ribose
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.2
            ExPASy - ENZYME nomenclature database: 3.2.2.2
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.2
            BRENDA, the Enzyme Database: 3.2.2.2
///
ENTRY       EC 3.2.2.3
NAME        Uridine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Uridine ribohydrolase
REACTION    Uridine + H2O = Uracil + D-Ribose
SUBSTRATE   Uridine
            H2O
PRODUCT     Uracil
            D-Ribose
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       MMU: 109352(Ung)
STRUCTURES  PDB: 5EUG  4EUG  1UDH  3EUG  2UUG  2SSP  2EUG  1UUG  1UGH  1UDI  
                 1UDG  1SSP  1FLZ  1EUG  1EMJ  1EMH  4SKN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.3
            ExPASy - ENZYME nomenclature database: 3.2.2.3
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.3
            BRENDA, the Enzyme Database: 3.2.2.3
            SCOP (Structural Classification of Proteins): 3.2.2.3
///
ENTRY       EC 3.2.2.4
NAME        AMP nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     AMP phosphoribohydrolase
REACTION    AMP + H2O = Adenine + D-Ribose 5-phosphate
SUBSTRATE   AMP
            H2O
PRODUCT     Adenine
            D-Ribose 5-phosphate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b1982(amn)
            ECE: Z3139(amn)
            ECS: ECs2779
            YPE: YPO2288(amn)
            PAE: PA3970(amn)
            MLO: mll7714
            SME: SMc02386(amn)
            CCR: CC0264
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.4
            ExPASy - ENZYME nomenclature database: 3.2.2.4
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.4
            BRENDA, the Enzyme Database: 3.2.2.4
///
ENTRY       EC 3.2.2.5
NAME        NAD+ nucleosidase
            NADase
            DPNase
            DPN hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     NAD+ glycohydrolase
REACTION    NAD+ + H2O = Nicotinamide + ADPribose
SUBSTRATE   NAD+
            H2O
PRODUCT     Nicotinamide
            ADPribose
COMMENT     The enzyme from some animal sources also catalyses transfer of
            ADPribose residues.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       MMU: 105370(Bp3)
            HSA: 683(BST1) 952(CD38)
STRUCTURES  PDB: 1LBE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.5
            ExPASy - ENZYME nomenclature database: 3.2.2.5
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.5
            BRENDA, the Enzyme Database: 3.2.2.5
            SCOP (Structural Classification of Proteins): 3.2.2.5
///
ENTRY       EC 3.2.2.6
NAME        NAD(P)+ nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     NAD(P)+ glycohydrolase
REACTION    NAD+ or NADP+ + H2O = Nicotinamide + ADPribose or 
            ADPribose 2'-phosphate
SUBSTRATE   NAD+
            NADP+
            H2O
PRODUCT     Nicotinamide
            ADPribose
            ADPribose 2'-phosphate
COMMENT     Also catalyses transfer of ADPribose(P) residues.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.6
            ExPASy - ENZYME nomenclature database: 3.2.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.6
            BRENDA, the Enzyme Database: 3.2.2.6
///
ENTRY       EC 3.2.2.7
NAME        Adenosine nucleosidase
            Adenosinase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Adenosine ribohydrolase
REACTION    Adenosine + H2O = Adenine + D-Ribose
SUBSTRATE   Adenosine
            H2O
PRODUCT     Adenine
            D-Ribose
COMMENT     Also acts on adenosine N-oxide.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.7
            ExPASy - ENZYME nomenclature database: 3.2.2.7
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.7
            BRENDA, the Enzyme Database: 3.2.2.7
///
ENTRY       EC 3.2.2.8
NAME        Ribosylpyrimidine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Nucleoside ribohydrolase
REACTION    an N-D-Ribosylpyrimidine + H2O = a Pyrimidine + D-Ribose
SUBSTRATE   N-D-Ribosylpyrimidine
            H2O
PRODUCT     Pyrimidine
            D-Ribose
COMMENT     Also hydrolyses purine D-ribonucleosides, more slowly.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.8
            ExPASy - ENZYME nomenclature database: 3.2.2.8
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.8
            BRENDA, the Enzyme Database: 3.2.2.8
///
ENTRY       EC 3.2.2.9
NAME        Adenosylhomocysteine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     S-Adenosyl-L-homocysteine homocysteinylribohydrolase
REACTION    S-Adenosyl-L-homocysteine + H2O = Adenine +
            S-D-Ribosyl-L-homocysteine
SUBSTRATE   S-Adenosyl-L-homocysteine
            H2O
            5'-Methylthioadenosine
PRODUCT     Adenine
            S-D-Ribosyl-L-homocysteine
            5-Methylthio-D-ribose
COMMENT     Also acts on 5'-methylthioadenosine to give adenine and
            5-methylthioribose (cf. EC 3.2.2.16).
PATHWAY     PATH: MAP00271  Methionine metabolism
GENES       ECO: b0159(pfs)
            ECE: Z0170(pfs)
            ECS: ECs0163
            HIN: HI1216
            PMU: PM0194(pfs)
            VCH: VC2379
            BUC: BU210(pfs)
            NME: NMB0767
            NMA: NMA0978(pfs)
            HPY: HP0089
            HPJ: jhp0082
            CJE: Cj0117(pfs)
            SME: SMc00395(pfs)
            CCR: CC2266
            BSU: BG13800(yrrU)
            BHA: BH1279 BH3238(pfs)
            SAU: SA1427(pfs)
            SAV: SAV1587(pfs)
            LLA: L132777(pfs)
            SPY: SPy0447(pfs)
            SPN: SP0991
            SPR: spr0894(pfs)
            CAC: CAC2117(pfs)
            MPU: MYPU_3360(pfs)
            MTU: Rv0091
            MTC: MT0100
            BBU: BBI06(pfs)
            TPA: TP0170
            DRA: DR1451
            TMA: TM1129
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.9
            ExPASy - ENZYME nomenclature database: 3.2.2.9
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.9
            BRENDA, the Enzyme Database: 3.2.2.9
///
ENTRY       EC 3.2.2.10
NAME        Pyrimidine-5'-nucleotide nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase
REACTION    a Pyrimidine 5'-nucleotide + H2O = a Pyrimidine + 
            D-Ribose 5-phosphate
SUBSTRATE   Pyrimidine 5'-nucleotide
            H2O
            dUMP
            dTMP
            dCMP
PRODUCT     Pyrimidine
            Uracil
            Thymine
            Cytosine
            D-Ribose 5-phosphate
            2-Deoxy-D-ribose 5-phosphate
COMMENT     Also acts on dUMP, dTMP and dCMP.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.10
            ExPASy - ENZYME nomenclature database: 3.2.2.10
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.10
            BRENDA, the Enzyme Database: 3.2.2.10
///
ENTRY       EC 3.2.2.11
NAME        beta-Aspartyl-N-acetylglucosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     1-beta-Aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase
REACTION    1-beta-Aspartyl-N-acetyl-D-glucosaminylamine + H2O =
            N-Acetyl-D-glucosamine + L-Asparagine
SUBSTRATE   1-beta-Aspartyl-N-acetyl-D-glucosaminylamine
            H2O
PRODUCT     N-Acetyl-D-glucosamine
            L-Asparagine
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.11
            ExPASy - ENZYME nomenclature database: 3.2.2.11
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.11
            BRENDA, the Enzyme Database: 3.2.2.11
///
ENTRY       EC 3.2.2.12
NAME        Inosinate nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     5'-Inosinate phosphoribohydrolase
REACTION    5'-Inosinate + H2O = Hypoxanthine + D-Ribose 5-phosphate
SUBSTRATE   5'-Inosinate
            H2O
PRODUCT     Hypoxanthine
            D-Ribose 5-phosphate
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.12
            ExPASy - ENZYME nomenclature database: 3.2.2.12
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.12
            BRENDA, the Enzyme Database: 3.2.2.12
///
ENTRY       EC 3.2.2.13
NAME        1-Methyladenosine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     1-Methyladenosine ribohydrolase
REACTION    1-Methyladenosine + H2O = 1-Methyladenine + D-Ribose
SUBSTRATE   1-Methyladenosine
            H2O
PRODUCT     1-Methyladenine
            D-Ribose
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.13
            ExPASy - ENZYME nomenclature database: 3.2.2.13
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.13
            BRENDA, the Enzyme Database: 3.2.2.13
///
ENTRY       EC 3.2.2.14
NAME        NMN nucleosidase
            NMNase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Nicotinamide-nucleotide phosphoribohydrolase
REACTION    Nicotinamide D-ribonucleotide + H2O = Nicotinamide + D-Ribose
SUBSTRATE   Nicotinamide D-ribonucleotide
            H2O
PRODUCT     Nicotinamide
            D-Ribose
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.14
            ExPASy - ENZYME nomenclature database: 3.2.2.14
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.14
            BRENDA, the Enzyme Database: 3.2.2.14
///
ENTRY       EC 3.2.2.15
NAME        DNA-deoxyinosine glycosidase
            DNA(hypoxanthine) glycohydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     DNA-deoxyinosine deoxyribohydrolase
REACTION    Hydrolyses DNA and polynucleotides, releasing free hypoxanthine.
SUBSTRATE   DNA
            Polynucleotide
            H2O
PRODUCT     Hypoxanthine
            DNA
            Polynucleotide
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.15
            ExPASy - ENZYME nomenclature database: 3.2.2.15
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.15
            BRENDA, the Enzyme Database: 3.2.2.15
///
ENTRY       EC 3.2.2.16
NAME        Methylthioadenosine nucleosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Methylthioadenosine methylthioribohydrolase
REACTION    Methylthioadenosine + H2O = Adenine + 5-Methylthio-D-ribose
SUBSTRATE   Methylthioadenosine
            H2O
PRODUCT     Adenine
            5-Methylthio-D-ribose
COMMENT     Does not act on S-adenosylhomocysteine. cf. EC 3.2.2.9.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b0159(pfs)
            ECE: Z0170(pfs)
            ECS: ECs0163
            YPE: YPO3384(mtn)
            HIN: HI1216
            PMU: PM0194(pfs)
            VCH: VC2379
            BUC: BU210(pfs)
            NME: NMB0767
            NMA: NMA0978(pfs)
            HPY: HP0089
            HPJ: jhp0082
            CJE: Cj0117(pfs)
            SME: SMc00395(pfs)
            CCR: CC2266
            BSU: BG13800(yrrU)
            BHA: BH1279 BH3238(pfs)
            SAU: SA1427(pfs)
            SAV: SAV1587(pfs)
            LLA: L132777(pfs)
            SPY: SPy0447(pfs)
            SPN: SP0991
            SPR: spr0894(pfs)
            CAC: CAC2117(pfs)
            MPU: MYPU_3360(pfs)
            MTU: Rv0091
            MTC: MT0100
            BBU: BBI06(pfs)
            TPA: TP0170
            DRA: DR1451
            TMA: TM1129
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.16
            ExPASy - ENZYME nomenclature database: 3.2.2.16
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.16
            BRENDA, the Enzyme Database: 3.2.2.16
///
ENTRY       EC 3.2.2.17
NAME        Deoxyribodipyrimidine endonucleosidase
            Pyrimidine dimer DNA-glycosylase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase
REACTION    Cleaves the N-glycosidic bond between the 5'-pyrimidine residue in
            cyclobutadipyrimidine (in DNA) and the corresponding
            deoxy-D-ribose residue.
SUBSTRATE   Cyclobutadipyrimidine (in DNA)
            H2O
PRODUCT     DNA
STRUCTURES  PDB: 1I20  1I1Z  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.17
            ExPASy - ENZYME nomenclature database: 3.2.2.17
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.17
            BRENDA, the Enzyme Database: 3.2.2.17
            SCOP (Structural Classification of Proteins): 3.2.2.17
///
ENTRY       EC 3.2.2.18
NAME        Deleted entry
            Glycopeptide N-glycosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
COMMENT     Deleted entry. Now included with EC 3.5.1.52.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.18
            ExPASy - ENZYME nomenclature database: 3.2.2.18
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.18
///
ENTRY       EC 3.2.2.19
NAME        ADPribosylarginine hydrolase
            ADP-ribose-L-arginine cleaving enzyme
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     N2-(ADP-D-ribosyl)-L-arginine ADPribosylhydrolase
REACTION    N2-(ADP-D-ribosyl)-L-arginine + H2O = L-Arginine + ADPribose
SUBSTRATE   N2-(ADP-D-ribosyl)-L-arginine
            H2O
PRODUCT     L-Arginine
            ADPribose
GENES       HSA: 141(ADPRH)
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.19
            ExPASy - ENZYME nomenclature database: 3.2.2.19
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.19
            BRENDA, the Enzyme Database: 3.2.2.19
///
ENTRY       EC 3.2.2.20
NAME        DNA-3-methyladenine glycosidase I
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Alkylated-DNA glycohydrolase (releasing methyladenine)
REACTION    Hydrolysis of alkylated DNA, releasing 3-methyladenine
SUBSTRATE   Alkylated DNA
            H2O
PRODUCT     3-Methyladenine
COMMENT     Involved in the removal of alkylated bases from DNA in
            Eschrichia coli. (cf. EC 2.1.1.63).
GENES       ECO: b3549(tag)
            ECE: Z4974(tag)
            ECS: ECs4434
            YPE: YPO4074(tag)
            HIN: HI0654(tag)
            PMU: PM1601(tagI)
            VCH: VC1672
            PAE: PA0010(tag)
            NME: NMB1673
            NMA: NMA1931(tag)
            MLO: mlr6925
            SME: SMc00923(tag)
            CCR: CC0382
            SAU: SA1489(tag)
            SAV: SAV1648(tag)
            LLA: L0289(tag)
            SPY: SPy2118(tag)
            SPN: SP0180
            SPR: spr0166(tag)
            MTU: Rv1210(tagA)
            MTC: MT1248
            MLE: ML1066(tagA)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
STRUCTURES  PDB: 1F6O  1F4R  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.20
            ExPASy - ENZYME nomenclature database: 3.2.2.20
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.20
            BRENDA, the Enzyme Database: 3.2.2.20
            SCOP (Structural Classification of Proteins): 3.2.2.20
///
ENTRY       EC 3.2.2.21
NAME        DNA-3-methyladenine glycosidase II
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     Alkylated-DNA glycohydrolase (releasing methyladenine and
            methylguanine)
REACTION    Hydrolysis of alkylated DNA, releasing 3-methyladenine,
            3-methylguanine, 7-methylguanine and 7-methyladenine.
SUBSTRATE   Alkylated DNA
            H2O
PRODUCT     3-Methyladenine
            3-Methylguanine
            7-Methylguanine
            7-Methyladenine
COMMENT     Involved in the removal of alkylated bases from DNA in
            Escherichia coli (cf. EC 2.1.1.63).
GENES       ECO: b2068(alkA)
            ECE: Z3237(alkA)
            ECS: ECs2877
            PAE: PA1686(alkA)
            RPR: RP351(mpg)
            RCO: RC0480(mpg)
            MLO: mll3478 mll4583
            SME: SMb20709 SMc00736
            CCR: CC2201
            BSU: BG10165(alkA) BG12555(yxlJ) BG12912(yfjP)
            BHA: BH1749
            SAU: SA2134
            SAV: SAV2329
            CAC: CAC2969
            MPU: MYPU_0950(ogt)
            MTU: Rv1688
            MTC: MT1727.1
            MLE: ML1351
            CPN: CPn0505
            CPA: CP0248
            CPJ: CPj0505
            BBU: BB0422(mag)
            SYN: slr0231
            DRA: DR2074 DR2584
            AFU: AF2117(alkA)
            HAL: VNG1311G(alkA)
            PHO: PH0784
            PAB: PAB1530(alkA)
            APE: APE0275 APE2247
            SCE: YER142C(MAG1)
            SPO: MAG1(mag1) SPBC23G7.11(spbc23g7.11)
            MMU: 97073(Mpg)
            HSA: 4350(MPG)
DISEASE     MIM: 156565  N-methylpurine DNA glycosylase
MOTIF       PS: PS00516  G-I-G-x-W-[ST]-[AV]-x-[LIVMFY](2)-x-[LIVM]-x(8)-[MF]-
                         x(2)-[ED]-D
STRUCTURES  PDB: 1BNK  1EWN  1MPG  1DIZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.21
            ExPASy - ENZYME nomenclature database: 3.2.2.21
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.21
            BRENDA, the Enzyme Database: 3.2.2.21
            SCOP (Structural Classification of Proteins): 3.2.2.21
///
ENTRY       EC 3.2.2.22
NAME        rRNA N-glycosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     rRNA N-glycohydrolase
REACTION    Endohydrolysis of the N-glycosidic bond at one specific
            position in 28S rRNA from rat ribosomes
SUBSTRATE   28S rRNA
            H2O
PRODUCT     rRNA
COMMENT     Ricin A-chain and related toxins show this activity.
            Naked rRNA is attacked more slowly than rRNA in intact
            ribosomes. Naked rRNA from Escherichia coli is cleaved
            at a corresponding position.
MOTIF       PS: PS00275  [LIVMA]-x-[LIVMSTA](2)-x-E-[SAGV]-[STAL]-R-[FY]-
                         [RKNQS]-x-[LIVM]-[EQS]-x(2)-[LIVMF]
STRUCTURES  PDB: 1FMP  1F8Q  1OBS  1OBT  1QD2  1QI7  1RTC  1TCS  1IFT  1D6A  
                 1BRY  1BR6  1BR5  1AHC  1AHB  1AHA  1HWP  1IFS  1HWM  2AAI  
                 1HWN  1DM0  1IFU  1MOM  1HWO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.22
            ExPASy - ENZYME nomenclature database: 3.2.2.22
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.22
            BRENDA, the Enzyme Database: 3.2.2.22
            SCOP (Structural Classification of Proteins): 3.2.2.22
///
ENTRY       EC 3.2.2.23
NAME        Formamidopyrimidine-DNA glycosidase
            Fapy-DNA glycosilase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     DNA glycohydrolase (releasing 2,6-diamino-4-hydroxy-5-(N-methyl)-
            -formamidopyrimidine)
REACTION    Hydrolysis of DNA containing ring-opened N7-methylguanine
            residues, releasing 2,6-diamino-4-hydroxy-5-(N-
            methyl)formamidopyrimidine
SUBSTRATE   DNA
            H2O
PRODUCT     2,6-Diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
GENES       ECO: b3635(mutM)
            ECE: Z5059(mutM)
            ECS: ECs4510
            YPE: YPO0052(mutM)
            HIN: HI0946(mutM)
            PMU: PM1145(fpg)
            XFA: XF0071 XF0170
            VCH: VC0221
            PAE: PA0357(mutM)
            NME: NMB1295
            NMA: NMA1505(fpg)
            RCO: RC1038(mutM)
            MLO: mll5585
            SME: SMc01154(fpg)
            CCR: CC3707
            BSU: BG12628(mutM)
            BHA: BH3152(mutM)
            SAU: SA1512
            SAV: SAV1675(mutM)
            LLA: L0271(mutM)
            SPY: SPy0497(fpg)
            SPN: SP0970
            SPR: spr0872(mutM)
            MGE: MG262.1
            MPN: A19_orf277(fpg)
            MPU: MYPU_3100(fpg)
            UUR: UU413(fpg)
            MTU: Rv0944 Rv2924c(fpg)
            MTC: MT0970 MT2994
            MLE: ML1658(fpg)
            SYN: slr1689(mutM)
            DRA: DR0493
MOTIF       PS: PS01242  C-x(1,4)-C-[GANH]-x(2)-[IVM]-x(7,11)-R-[GSANPV]-x(2)-
                         [FYWIL]-C-x(2)-C-Q
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.23
            ExPASy - ENZYME nomenclature database: 3.2.2.23
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.23
            BRENDA, the Enzyme Database: 3.2.2.23
///
ENTRY       EC 3.2.2.24
NAME        ADP-ribosyl-[dinitrogen reductase] hydrolase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     ADP-D-ribosyl-[dinitrogen reductase] ADPribosylhydrolase
REACTION    ADP-D-ribosyl-[dinitrogen reductase] + H2O =
            [Dinitrogen reductase] + ADP-D-ribose
SUBSTRATE   ADP-D-ribosyl-[dinitrogen reductase]
            H2O
PRODUCT     [Dinitrogen reductase]
            ADP-D-ribose
COMMENT     Together with EC 2.4.2.37, controls the level of activity of
            EC 1.18.6.1.
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.2.24
            ExPASy - ENZYME nomenclature database: 3.2.2.24
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.24
            BRENDA, the Enzyme Database: 3.2.2.24
///
ENTRY       EC 3.2.3.1
NAME        Thioglucosidase
            Myrosinase
            Sinigrinase
            Sinigrase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing S-glycosyl compounds
SYSNAME     Thioglucoside glucohydrolase
REACTION    a Thioglucoside + H2O = a Thiol + a Sugar
SUBSTRATE   Thioglucoside
            H2O
PRODUCT     Thiol
            Sugar
COMMENT     Has a wide specificity for thioglycosides.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       ATH: At5g25980(T1N24.18) At5g26000(T1N24.7)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
STRUCTURES  PDB: 1E6S  1DWA  1DWF  1DWG  1DWH  1DWI  1DWJ  1E4M  1E6Q  1E6X  
                 1E70  1E71  1E72  1E73  1MYR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.2.3.1
            ExPASy - ENZYME nomenclature database: 3.2.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.2.3.1
            BRENDA, the Enzyme Database: 3.2.3.1
            SCOP (Structural Classification of Proteins): 3.2.3.1
///
ENTRY       EC 3.3.1.1
NAME        Adenosylhomocysteinase
CLASS       Hydrolases
            Acting on ether bonds
            Thioether hydrolases
SYSNAME     S-Adenosyl-L-homocysteine hydrolase
REACTION    S-Adenosyl-L-homocysteine + H2O = Adenosine + L-Homocysteine
SUBSTRATE   S-Adenosyl-L-homocysteine
            H2O
PRODUCT     Adenosine
            L-Homocysteine
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
GENES       XFA: XF1037
            PAE: PA0432(sahH)
            MLO: mll5088
            SME: SMc02755(ahcY)
            CCR: CC0257
            MTU: Rv3248c(sahH)
            MTC: MT3346
            MLE: ML0771(sahH)
            SYN: sll1234(ahcY)
            AAE: aq_1180(sahH)
            TMA: TM0172
            MJA: MJ1388(ahcY)
            MTH: MTH1636
            AFU: AF0886(ahcY-1) AF2000(ahcY-2)
            HAL: VNG2251G(achY)
            TAC: Ta0469
            TVO: TVG1039754
            PHO: PH0540
            PAB: PAB1372(ahcY)
            APE: APE0624
            SSO: SSO0755(ahcY)
            STO: ST0342
            SCE: YER043C(SAH1)
            SPO: SPBC8D2.18C(spbc8d2.18c)
            ATH: At4g13940(dl3010w)
            CEL: K02F2.2
            DME: CG11654(Ahcy13) CG8956(Ahcy89E) CG9977
            HSA: 10768(AHCYL1) 191(AHCY)
DISEASE     MIM: 180960  S-adenosylhomocysteine hydrolase
MOTIF       PS: PS00738  [GSA]-[CS]-N-x-[FYLM]-S-[ST]-[QA]-[DEN]-x-[AV]-[AVT]-
                         [ADE]-[AC]-[LIVMCG]
            PS: PS00739  [GA]-[KS]-x(3)-[LIV]-x-G-[FY]-G-x-[VC]-G-[KRL]-G-x-
                         [ASC]
STRUCTURES  PDB: 1D4G  1A7A  1B3R  1D4F  
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.1.1
            ExPASy - ENZYME nomenclature database: 3.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.3.1.1
            BRENDA, the Enzyme Database: 3.3.1.1
            SCOP (Structural Classification of Proteins): 3.3.1.1
///
ENTRY       EC 3.3.1.2
NAME        Adenosylmethionine hydrolase
            S-Adenosylmethionine cleaving enzyme
            Methylmethionine-sulfonium-salt hydrolase
CLASS       Hydrolases
            Acting on ether bonds
            Thioether hydrolases
SYSNAME     S-Adenosyl-L-methionine hydrolase
REACTION    S-Adenosyl-L-methionine + H2O = Methylthioadenosine + L-Homoserine
SUBSTRATE   S-Adenosyl-L-methionine
            H2O
            Methylmethionine sulfonium salt
PRODUCT     Methylthioadenosine
            L-Homoserine
            Dimethyl sulfide
COMMENT     Also hydrolyses methylmethionine sulfonium salt to dimethyl
            sulfide and homoserine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.1.2
            ExPASy - ENZYME nomenclature database: 3.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.3.1.2
            BRENDA, the Enzyme Database: 3.3.1.2
///
ENTRY       EC 3.3.1.3
NAME        Ribosylhomocysteinase
CLASS       Hydrolases
            Acting on ether bonds
            Thioether hydrolases
SYSNAME     S-Ribosyl-L-homocysteine ribohydrolase
REACTION    S-Ribosyl-L-homocysteine + H2O = D-Ribose + L-Homocysteine
SUBSTRATE   S-Ribosyl-L-homocysteine
            H2O
PRODUCT     D-Ribose
            L-Homocysteine
PATHWAY     PATH: MAP00271  Methionine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.1.3
            ExPASy - ENZYME nomenclature database: 3.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.3.1.3
            BRENDA, the Enzyme Database: 3.3.1.3
///
ENTRY       EC 3.3.2.1
NAME        Isochorismatase
            2,3-Dihydro-2,3-dihydroxybenzoate synthase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     Isochorismate pyruvate-hydrolase
REACTION    Isochorismate + H2O = 2,3-Dihydro-2,3-dihydroxybenzoate +
            Pyruvate
SUBSTRATE   Isochorismate
            H2O
PRODUCT     2,3-Dihydro-2,3-dihydroxybenzoate
            Pyruvate
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b0595(entB)
            ECE: Z0737(entB)
            ECS: ECs0634
            VCH: VC0771
            SME: SMb21405
            BSU: BG11241(dhbB) BG12490(ywoC)
            AFU: AF2151(entB)
            HAL: VNG2537G(entB)
            TAC: Ta0454
            TVO: TVG0787823
            APE: APE2350
            SSO: SSO2455(entB-like2)
            STO: ST0582
MOTIF       PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.1
            ExPASy - ENZYME nomenclature database: 3.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.1
            BRENDA, the Enzyme Database: 3.3.2.1
///
ENTRY       EC 3.3.2.2
NAME        Alkenylglycerophosphocholine hydrolase
            Lysoplasmalogenase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     1-(1-Alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase
REACTION    1-(1-Alkenyl)-sn-glycero-3-phosphocholine + H2O = an Aldehyde +
            sn-Glycero-3-phosphocholine
SUBSTRATE   1-(1-Alkenyl)-sn-glycero-3-phosphocholine
            H2O
PRODUCT     Aldehyde
            sn-Glycero-3-phosphocholine
PATHWAY     PATH: MAP00580  Phospholipid degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.2
            ExPASy - ENZYME nomenclature database: 3.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.2
            BRENDA, the Enzyme Database: 3.3.2.2
///
ENTRY       EC 3.3.2.3
NAME        Epoxide hydrolase
            Epoxide hydratase
            Arene-oxide hydratase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     Epoxide hydrolase
REACTION    an Epoxide + H2O = a Glycol
SUBSTRATE   Epoxide
            Arene oxide
            H2O
PRODUCT     Glycol
            Arene diol
COMMENT     Acts on a variety of epoxides and arene oxides. Formerly
            EC 4.2.1.63 and 4.2.1.64.
PATHWAY     PATH: MAP00625  Tetrachloroethene degradation
GENES       CCR: CC1229
            CEL: W01A11.1
            DME: CG15101 CG15102 CG15106
            MMU: 95405(Ephx1) 99500(Ephx2)
            HSA: 2052(EPHX1) 2053(EPHX2)
DISEASE     MIM: 132810  Epoxide hydroxylase 1, microsomal xenobiotic
            MIM: 132811  Epoxide hydrolase 2, cytoplasmic
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1CR6  1CQZ  1EHY  1EK1  1EK2  1QO7  
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.3
            ExPASy - ENZYME nomenclature database: 3.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.3
            UM-BBD (Biocatalysis/Biodegradation Database): 3.3.2.3
            BRENDA, the Enzyme Database: 3.3.2.3
            SCOP (Structural Classification of Proteins): 3.3.2.3
///
ENTRY       EC 3.3.2.4
NAME        trans-Epoxysuccinate hydrolase
            trans-Epoxysuccinate hydratase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     trans-2,3-Epoxysuccinate hydrolase
REACTION    trans-2,3-Epoxysuccinate + H2O = meso-Tartaric acid
SUBSTRATE   trans-2,3-Epoxysuccinate
            H2O
PRODUCT     meso-Tartaric acid
COMMENT     Acts on both optical isomers of the substrate.
            Formerly EC 4.2.1.37.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.4
            ExPASy - ENZYME nomenclature database: 3.3.2.4
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.4
            BRENDA, the Enzyme Database: 3.3.2.4
///
ENTRY       EC 3.3.2.5
NAME        Alkenylglycerophosphoethanolamine hydrolase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase
REACTION    1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine + H2O =
            an Aldehyde + sn-Glycero-3-phosphoethanolamine
SUBSTRATE   1-(1-Alkenyl)-sn-glycero-3-phosphoethanolamine
            H2O
PRODUCT     Aldehyde
            sn-Glycero-3-phosphoethanolamine
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.5
            ExPASy - ENZYME nomenclature database: 3.3.2.5
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.5
            BRENDA, the Enzyme Database: 3.3.2.5
///
ENTRY       EC 3.3.2.6
NAME        Leukotriene-A4 hydrolase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
            hydrolase
REACTION    (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate +
            H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate
SUBSTRATE   (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
            H2O
            4,5-Leukotriene A4
PRODUCT     (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate
            Leukotriene B4
COMMENT     Converts 4,5-leukotriene A4 into leukotriene B4. Highly specific.
            Not identical with EC 3.3.2.3.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       SCE: YNL045W
            SPO: SPCC1322.05C(spcc1322.05c)
            CEL: C42C1.11 ZC416.6
            DME: CG10602
            HSA: 4048(LTA4H)
DISEASE     MIM: 151570  Leukotriene A4 hydrolase
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1HS6  
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.6
            ExPASy - ENZYME nomenclature database: 3.3.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.6
            BRENDA, the Enzyme Database: 3.3.2.6
///
ENTRY       EC 3.3.2.7
NAME        Hepoxilin-epoxide hydrolase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     (5Z,9E,14Z)-(8xi,11R,12S)-11,12-Epoxy-8-hydroxyicosa-5,9,14-
            $trienoate hydrolase
REACTION    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-Epoxy-8-hydroxyeicosa-5,9,14-
            $trienoate + H2O = (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-
            $Trihydroxyeicosa-5,9,14-trienoate
SUBSTRATE   (5Z,9E,14Z)-(8xi,11R,12S)-11,12-Epoxy-8-hydroxyeicosa-5,9,14-
            $trienoate
            H2O
            Hepoxilin A3
PRODUCT     (5Z,9E,14Z)-(8xi,11xi,12S)-8,11,12-Trihydroxyeicosa-5,9,14-
            $trienoate
            Trioxilin A3
COMMENT     Converts hepoxilin A3 into trioxilin A3. Highly specific. Not
            identical with EC 3.3.2.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.3.2.7
            ExPASy - ENZYME nomenclature database: 3.3.2.7
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.7
            BRENDA, the Enzyme Database: 3.3.2.7
///
ENTRY       EC 3.4.11.1
NAME        Leucyl aminopeptidase
            Leucine aminopeptidase
            Leucyl peptidase
            Peptidase S
            Cytosol aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, Xaa-|-Xbb-, in which Xaa is
            preferably Leu, but may be other amino acids including Pro
            although not Arg or Lys, and Xbb may be Pro. Amino acid amides
            and methyl esters are also readily hydrolysed, but rates on
            arylamides are exceedingly low.
SUBSTRATE   Peptide
            H2O
PRODUCT     N-Terminal amino acid
            Peptide
INHIBITOR   Amastatin
COFACTOR    Zinc
EFFECTOR    Heavy metal ion
COMMENT     A zinc enzyme isolated from pig kidney and cattle lens; activated
            by heavy metal ions. Formerly EC 3.4.1.1.
            Inhibited by amastatin ( H.Kim and W.N.Lipscomb, Biochemistry,
            32, 8465-8478 (1993) ).
GENES       ECO: b4260(pepA)
            ECE: Z5872(pepA)
            ECS: ECs5237
            YPE: YPO3441(pepA)
            HIN: HI1705(pepA)
            PMU: PM0195(pepA)
            XFA: XF0138
            VCH: VC2501
            PAE: PA3831
            BUC: BU367(pepA)
            NMA: NMA1758(pepA)
            HPY: HP0570(pepA)
            HPJ: jhp0517
            CJE: Cj0929(pepA)
            RPR: RP142(pepA)
            RCO: RC0184(pepA)
            MLO: mll0602 mlr5606 mlr7868
            SME: SMc00585(pepA)
            CCR: CC0977 CC1692
            BSU: BG13970(yuiE)
            BHA: BH3401
            SAU: SA0803(ampA)
            SAV: SAV0929
            MGE: MG391
            MPN: D02_orf445
            MPU: MYPU_3750(pepA) MYPU_7260(pepA)
            UUR: UU507(ampL)
            MTU: Rv2213(pepB)
            MTC: MT2269
            MLE: ML0864(pepA)
            CTR: CT045
            CMU: TC0315
            CPN: CPn0385
            CPA: CP0370
            CPJ: pepA
            BBU: BB0366(yscI)
            SYN: sll2001(lap)
            DRA: DR0717
            AAE: aq_2099(pepA)
            APE: APE2450
            SPO: SPAC13A11.05(spac13a11.05)
            ATH: At2g24200(F27D4.11)
            CEL: W07G4.4 ZK353.6
            DME: CG13340 CG4439 CG9285
            HSA: 5186(PEPS)
MOTIF       PS: PS00631  [NS]-T-D-A-E-G-R-[LV]
STRUCTURES  PDB: 1LAM  1BLL  1BPM  1BPN  1LAN  1LAP  1LCP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.1
            ExPASy - ENZYME nomenclature database: 3.4.11.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.1
            BRENDA, the Enzyme Database: 3.4.11.1
            SCOP (Structural Classification of Proteins): 3.4.11.1
///
ENTRY       EC 3.4.11.2
NAME        Membrane alanyl aminopeptidase
            Microsomal aminopeptidase
            Aminopeptidase M
            Aminopeptidase N
            Particle-bound aminopeptidase
            Amino-oligopeptidase
            Alanine aminopeptidase
            Membrane aminopeptidase I
            Pseudo leucine aminopeptidase
            Peptidase E
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, Xaa-|-Xbb- from a peptide,
            amide or arylamide. Xaa is preferably Ala, byt may be most amino
            acids including Pro (slow action). When a terminal hydrophobic
            residue is followed by a prolyl residue, the two may be released
            as an intact Xaa-Pro dipeptide
SUBSTRATE   Peptide
            H2O
            Arylamide
            Amide
PRODUCT     N-Terminal amino acid
            Peptide
COFACTOR    Zinc
COMMENT     A zinc enzyme, not activated by heavy metal ions. Formerly
            EC 3.4.1.2.
GENES       ECO: b0932(pepN)
            ECE: Z1280(pepN)
            ECS: ECs1015
            YPE: YPO1414(pepN)
            HIN: HI1614(pepN)
            PMU: PM0618(pepN)
            XFA: XF1488
            VCH: VC1494
            PAE: PA3083(pepN)
            NME: NMB1416
            NMA: NMA1627(pepN)
            MLO: mll7701
            SME: SMc02370(pepN)
            CCR: CC2481
            SPR: spr0706(pepN)
            MTU: Rv2467(pepD)
            MTC: MT2542
            MLE: ML1486
            CEL: T07F10.1
            DME: CG7653(BG:DS00365.1)
            MMU: 96749(Lap1)
            HSA: 290(ANPEP) 5185(PEPE)
DISEASE     MIM: 151530  Alanyl (membrane) aminopeptidase (aminopeptidase N,
                         aminopeptidase M,
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.2
            ExPASy - ENZYME nomenclature database: 3.4.11.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.2
            BRENDA, the Enzyme Database: 3.4.11.2
///
ENTRY       EC 3.4.11.3
NAME        Cystinyl aminopeptidase
            Cystyl-aminopeptidase
            Oxytocinase
            Cystine aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, Cys-|-Xaa, in which the half-
            -cystine residue is involved in a disulfide loop, notably in
            oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl
            arylamides exceed that for the cystinyl derivative.
SUBSTRATE   Oxytocin
            Vasopressin
            H2O
PRODUCT     L-Cysteine
            Oligopeptide
COFACTOR    Zinc
COMMENT     A zinc-containing sialoglycoprotein.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.3
            ExPASy - ENZYME nomenclature database: 3.4.11.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.3
            BRENDA, the Enzyme Database: 3.4.11.3
///
ENTRY       EC 3.4.11.4
NAME        Tripeptide aminopeptidase
            Tripeptidase
            Aminotripeptidase
            Aminoexotripeptidase
            Lymphopeptidase
            Imidoendopeptidase
            Peptidase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of the N-terminal residue from a tripeptide
SUBSTRATE   Tripeptide
            H2O
PRODUCT     Amino acid
            Dipeptide
COFACTOR    Zinc
COMMENT     A zinc enzyme, widely distributed in mammalian tissues.
            Formerly EC 3.4.1.3.
PATHWAY     PATH: MAP00480  Glutathione metabolism
GENES       HSA: 5182(PEPB)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.4
            ExPASy - ENZYME nomenclature database: 3.4.11.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.4
            BRENDA, the Enzyme Database: 3.4.11.4
///
ENTRY       EC 3.4.11.5
NAME        Prolyl aminopeptidase
            Proline aminopeptidase
            Pro-X aminopeptidase
            Cytosol aminopeptidase V
            Proline iminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal proline from a peptide
SUBSTRATE   Peptide
            H2O
            Polyproline
            Prolyl-2-naphthylamide
PRODUCT     L-Proline
            Peptide
COFACTOR    Manganese
COMMENT     A Mn2+-requiring enzyme present in the cytosol of mammalian and
            microbial cells. In contrast to the mommalian form, the bacterial
            form of the enzyme hydrolyses both polyproline and prolyl-2-
            -naphthylamide. The mammalian enzyme, which is not specific for
            prolyl bonds, is possibly identical with EC 3.4.11.1.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       YPE: YPO1781(pip)
            XFA: XF1510
            PAE: PA5080
            NME: NMB0927
            NMA: NMA1122(pip)
            MLO: mlr7803
            SME: SMc02547(pip1) SMc04031(pip2) SMc04033(pip3)
            CCR: CC1227
            SAU: SA0897
            SAV: SAV1031
            MGE: MG020(PIP)
            MPN: B01_orf309(pip)
            TAC: Ta0830
            TVO: TVG0960913
            SSO: SSO3115
            ATH: At2g14260(T1O16.15) At2g24200(F27D4.11)
MOTIF       PS: PS00631  [NS]-T-D-A-E-G-R-[LV]
STRUCTURES  PDB: 1AZW  1QTR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.5
            ExPASy - ENZYME nomenclature database: 3.4.11.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.5
            BRENDA, the Enzyme Database: 3.4.11.5
            SCOP (Structural Classification of Proteins): 3.4.11.5
///
ENTRY       EC 3.4.11.6
NAME        Arginyl aminopeptidase
            Arginine aminopeptidase
            Aminopeptidase B
            Cl--Activated arginine aminopeptidase
            Cytosol aminopeptidase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal arginine (and to a lesser extent lysine),
            preferentially from a dipeptide or a tripeptide.
SUBSTRATE   Dipeptide
            Tripeptide
            H2O
PRODUCT     L-Arginine
            Amino acid
            Dipeptide
COFACTOR    Cl-
COMMENT     Cytosolic enzyme from mammalian tissues, activated by Cl-.
GENES       HSA: 6051(RNPEP)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.6
            ExPASy - ENZYME nomenclature database: 3.4.11.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.6
            BRENDA, the Enzyme Database: 3.4.11.6
///
ENTRY       EC 3.4.11.7
NAME        Glutamyl aminopeptidase
            Aminopeptidase A
            Aspartate aminopeptidase
            Angiotensinase A
            Glutamyl peptidase
            Ca2+-activated glutamate aminopeptidase
            Membrane aminopeptidase II
            Antigen BP-1/6C3 of mouse B lymphocytes
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal glutamate (and to a lesser extent
            aspartate) from a peptide.
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Glutamate
            Peptide
COFACTOR    Calcium
COMMENT     Ca2+-activated and generally membrane-bound.
GENES       LLA: L193909(pepA)
            SPY: SPy0115(pepA)
            SPN: SP1865
            SPR: spr1682(pepA)
            MMU: 106645(Enpep)
            HSA: 2028(ENPEP)
DISEASE     MIM: 138297  Glutamyl aminopeptidase (aminopeptidase A)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.7
            ExPASy - ENZYME nomenclature database: 3.4.11.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.7
            BRENDA, the Enzyme Database: 3.4.11.7
///
ENTRY       EC 3.4.11.8
NAME        Transferred to EC 3.4.19.3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
COMMENT     Transferred entry. Now EC 3.4.19.3 - Pyroglutamyl-peptidase I.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.8
            ExPASy - ENZYME nomenclature database: 3.4.11.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.8
///
ENTRY       EC 3.4.11.9
NAME        X-Pro aminopeptidase
            Proline aminopeptidase
            Aminopeptidase P
            Aminoacylproline aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of any N-terminal amino acid, including proline, that is
            linked to proline, even from a dipeptide or tripeptide
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Prolyl-peptide
COFACTOR    Manganese
COMMENT     A Mn2+-dependent, generally membrane-bound enzyme present in both
            mammalian and bacterial cells.
GENES       ECO: b2908(pepP)
            ECE: Z4245(pepP)
            ECS: ECs3779
            YPE: YPO0910(pepP) YPO3004
            HIN: HI0816(pepP)
            PMU: PM1724(pepP)
            XFA: XF2009
            PAE: PA5224(pepP)
            BSU: BG11708(yqhT)
            LLA: L90422(pepP)
            SPY: SPy1824(pepP)
            SPN: SP0187
            SPR: spr0172(pepP)
            MGE: MG324(pepP)
            MPN: P01_orf354(pepX)
            MPU: MYPU_4880(pepP)
            UUR: UU532(pepP)
            CTR: CT574
            CMU: TC0863
            CPN: CPn0813
            CPA: CP1058
            CPJ: pepP
            SYN: sll0136(pepP)
            TMA: TM0042
            MTH: MTH981
            AFU: AF2034(pepQ)
            HAL: VNG1233G(pepQ2)
            CEL: R119.2
            DME: CG9581
            HSA: 7511(XPNPEP1) 7512(XPNPEP2)
DISEASE     MIM: 300145  X-prolyl aminopeptidase 2 (aminopeptidase P)
MOTIF       PS: PS00491  [HA]-[GSYR]-[LIVMT]-[SG]-H-x-[LIV]-G-[LIVM]-x-[IV]-H-
                         [DE]
STRUCTURES  PDB: 1JAW  1AZ9  1A16  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.9
            ExPASy - ENZYME nomenclature database: 3.4.11.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.9
            BRENDA, the Enzyme Database: 3.4.11.9
            SCOP (Structural Classification of Proteins): 3.4.11.9
///
ENTRY       EC 3.4.11.10
NAME        Bacterial leucyl aminopeptidase
            Aeromonas proteolytica aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, preferentially leucine, but
            not glutamic or aspartic acids
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
            L-Leucine
COFACTOR    Zinc
COMMENT     A zinc enzyme.  Forms of the enzyme have been isolated from
            Aeromonas proteolytica, E. coli and Staphylococcus thermophilus.
STRUCTURES  PDB: 1FT7  1IGB  1AMP  1CP6  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.10
            ExPASy - ENZYME nomenclature database: 3.4.11.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.10
            BRENDA, the Enzyme Database: 3.4.11.10
            SCOP (Structural Classification of Proteins): 3.4.11.10
///
ENTRY       EC 3.4.11.11
NAME        Deleted entry
            Aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.11
            ExPASy - ENZYME nomenclature database: 3.4.11.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.11
///
ENTRY       EC 3.4.11.12
NAME        Deleted entry
            Thermophilic aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.12
            ExPASy - ENZYME nomenclature database: 3.4.11.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.12
            BRENDA, the Enzyme Database: 3.4.11.12
///
ENTRY       EC 3.4.11.13
NAME        Clostridial aminopeptidase
            Clostridium histolyticum aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of any N-terminal amino acid, including proline and
            hydroxyproline, but no cleavage of Xaa-Pro-.
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
COFACTOR    Manganese
            Cobalt
COMMENT     A secreted enzyme from Clostridium histolyticum, requiring Mn2+
            or Co2+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.13
            ExPASy - ENZYME nomenclature database: 3.4.11.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.13
            BRENDA, the Enzyme Database: 3.4.11.13
///
ENTRY       EC 3.4.11.14
NAME        Cytosol alanyl aminopeptidase
            Arylamidase
            Aminopolypeptidase
            Thiol-activated aminopeptidase
            Human liver aminopeptidase
            Puromycin-sensitive aminopeptidase
            Soluble alanyl aminopeptidase
            Cytosol aminopeptidase III
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, preferentially alanine, from
            a wide range of peptides, amides and arylamides.
SUBSTRATE   Peptide
            Amide
            Arylamide
            H2O
PRODUCT     L-Alanine
            Peptide
COFACTOR    Cobalt
            Zinc
COMMENT     A puromycin-sensitive, Co2+-activated zinc-sialoglycoprotein that
            is generally cytosolic. Multiple forms are widely distributed in
            mammalian tissues and body fluids.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.14
            ExPASy - ENZYME nomenclature database: 3.4.11.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.14
            BRENDA, the Enzyme Database: 3.4.11.14
///
ENTRY       EC 3.4.11.15
NAME        Lysyl aminopeptidase
            Aminopeptidase Co
            Aminopeptidase (cobalt-activated)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal lysine
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Lysine
            Peptide
INHIBITOR   Zinc
            Manganese
COFACTOR    Cobalt
COMMENT     Requires Co2+; inhibited by Zn2+ and Mn2+. An enzyme from
            Saccharomyces cerevisiae that hydrolyses L-lysyl-4-nitroanilide
            and, more slowly, L-arginyl-4-nitroanilide.
GENES       SPY: SPy1239(pepN)
            AFU: AF0578
            HSA: 3829(KNPEP)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.15
            ExPASy - ENZYME nomenclature database: 3.4.11.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.15
            BRENDA, the Enzyme Database: 3.4.11.15
///
ENTRY       EC 3.4.11.16
NAME        X-Trp aminopeptidase
            Aminopeptidase W
            Aminopeptidase X-Trp
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of a variety of N-terminal residues (especially glutamate
            and leucine) from peptides, provided tryptophan (or at least
            phenylalanine or tyrosine) is the penultimate residue. Also acts
            on Glu-|-Trp, Leu-|-Trp and a number of other dipeptides.
SUBSTRATE   Peptide
            X-Trp
            H2O
PRODUCT     L-Glutamate
            L-Leucine
            Peptide
            Tryptophan
COMMENT     A glycoprotein containing Zn2+, from renal and intestinal brush
            border membranes.
GENES       HSA: 7524(XWNPEP)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.16
            ExPASy - ENZYME nomenclature database: 3.4.11.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.16
            BRENDA, the Enzyme Database: 3.4.11.16
///
ENTRY       EC 3.4.11.17
NAME        Tryptophanyl aminopeptidase
            Tryptophan aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Preferential release of N-terminal tryptophan
SUBSTRATE   Peptide
            H2O
            L-Tryptophanamide
PRODUCT     L-Tryptophan
            Peptide
            NH3
COFACTOR    Manganese
COMMENT     From Trichosporon cutaneum. Also acts on L-tryptophanamide.
            Requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.17
            ExPASy - ENZYME nomenclature database: 3.4.11.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.17
            BRENDA, the Enzyme Database: 3.4.11.17
///
ENTRY       EC 3.4.11.18
NAME        Methionyl aminopeptidase
            Methionine aminopeptidase
            Peptidase M
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal amino acids, preferentially methionine, from
            peptides and arylamides
SUBSTRATE   Peptide
            Arylamide
            H2O
PRODUCT     Amino acid
            L-Methionine
COMMENT     Membrane-bound enzyme present in both prokaryotes and eukaryotes.
            Releases methionine from nascent peptides.
GENES       ECO: b0168(map)
            ECE: Z0178(map)
            ECS: ECs0170
            YPE: YPO1043(ampM) YPO3337(map)
            HIN: HI1722(map)
            PMU: PM0459(map)
            XFA: XF0111
            VCH: VC2261
            PAE: PA2748 PA3657(map)
            BUC: BU230(map)
            NME: NMB2093
            NMA: NMA0337(map)
            HPY: HP1299(map)
            HPJ: jhp1219
            CJE: Cj1651c(map)
            RPR: RP824(map)
            RCO: RC1276(map)
            MLO: mlr0954
            SME: SMb21002(map2) SMc00298(map1)
            ATU: AGR_C_2957
            CCR: CC2677
            BSU: BG10447(map) BG12942(yflG)
            BHA: BH0156(map)
            SAU: SA1704(map)
            SAV: SAV1873(map)
            LLA: L883(pepM)
            SPY: SPy1354(map)
            SPN: SP1084
            SPR: spr0992(map)
            MGE: MG172(map)
            MPN: GT9_orf248(map)
            MPU: MYPU_5660(map)
            UUR: UU252(map)
            MTU: Rv0734(map') Rv2861c(map)
            MTC: MT0758 MT2929
            MLE: ML1576(mapB) ML1831(mapA)
            CTR: CT851
            CMU: TC0240
            CPN: CPn1009
            CPA: CP0844
            CPJ: map
            BBU: BB0105(map)
            TPA: TP0842
            SYN: sll0555 slr0786(map) slr0918(map)
            DRA: DR1311
            AAE: aq_076(map)
            TMA: TM1478
            MJA: MJ1329
            MTH: MTH1296
            AFU: AF1840(map)
            HAL: VNG1866G(map)
            TAC: Ta1439
            TVO: TVG0107310
            PHO: PH0628
            PAB: PAB1434
            APE: APE1114
            SSO: SSO0098
            STO: ST1419
            SCE: YBL091C(MAP2) YLR244C(MAP1)
            SPO: SPBC14C8.03(spbc14c8.03) SPBC3E7.10(spbc3e7.10)
            ATH: At2g44180(F6E13.38) At2g45240(F4L23.22)
            DME: CG13630 CG4008(und)
            HSA: 10988(MNPEP)
MOTIF       PS: PS00680  [MFY]-x-G-H-G-[LIVMC]-[GSH]-x(3)-H-x(4)-[LIVM]-x-[HN]-
                         [YWVH]
            PS: PS01202  [DA]-[LIVMY]-x-K-[LIVM]-D-x-G-x-[HQ]-[LIVM]-[DNS]-G-
                         x(3)-[DN]
STRUCTURES  PDB: 1C21  1C22  1C23  1C24  1C27  1MAT  1XGM  1XGN  1XGO  2MAT  
                 3MAT  4MAT  1BN5  1BOA  1B6A  1B59  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.18
            ExPASy - ENZYME nomenclature database: 3.4.11.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.18
            BRENDA, the Enzyme Database: 3.4.11.18
            SCOP (Structural Classification of Proteins): 3.4.11.18
///
ENTRY       EC 3.4.11.19
NAME        D-Stereospecific aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal D-Amino acid from a Peptide, Xaa-|-Yaa-, in
            which Xaa is preferably D-Ala, D-Ser or D-Thr. D-Amino acid amides
            and methyl esters also are hydrolysed, as is Clycine amide.
COMMENT     A thiol-dependent peptidase known from the Bacterium Ochrobactrum
            Anthropi.
            A homologue of serine-type D-Ala-D-Ala carboxypeptidase
            (EC 3.4.16.4)
            Not metal dependent; Probably has Serine at the active centre.
STRUCTURES  PDB: 1EI5  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.19
            ExPASy - ENZYME nomenclature database: 3.4.11.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.19
            BRENDA, the Enzyme Database: 3.4.11.19
            SCOP (Structural Classification of Proteins): 3.4.11.19
///
ENTRY       EC 3.4.11.20
NAME        Aminopeptidase EY
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Differs from the other aminopeptidases in broad sepcificity for
            Amino acids in the P1 position and the ability to hydrolyse
            peptides of 4 or 5 residues that contain Pro in the P1' position.
COMMENT     From the plasma fraction of Chicken egg yolk.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.20
            ExPASy - ENZYME nomenclature database: 3.4.11.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.20
            BRENDA, the Enzyme Database: 3.4.11.20
///
ENTRY       EC 3.4.11.21
NAME        Aminopeptidase V
            VP165
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal from polypeptides. aminoacyl-2-naphtylamides
            significantly hydrolyzed are those of leu, lys, met, ala and arg
COMMENT     Belongs to peptidase family M1.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.21
            ExPASy - ENZYME nomenclature database: 3.4.11.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.21
///
ENTRY       EC 3.4.11.22
NAME        Vacuolar aminopeptidase I
            Leucine aminopeptidase IV
            Aminopeptidase III
            Aminopeptidase YSCI
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    release of an N-terminal amino acid, preferably a neutral or
            hydrophobic one, from a polypeptide. aminoacyl-arylamides are poor
            substrates
COMMENT     Belongs to peptidase family M18.
GENES       BBU: BB0627(pepX)
            SCE: YKL103C(LAP4)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.11.22
            ExPASy - ENZYME nomenclature database: 3.4.11.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.22
///
ENTRY       EC 3.4.13.1
NAME        Transferred to EC 3.4.13.18
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now EC 3.4.13.18 - Cytosol nonspecific
            dipeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.1
            ExPASy - ENZYME nomenclature database: 3.4.13.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.1
///
ENTRY       EC 3.4.13.2
NAME        Transferred to EC 3.4.13.18
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now EC 3.4.13.18 - Cytosol nonspecific
            dipeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.2
            ExPASy - ENZYME nomenclature database: 3.4.13.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.2
///
ENTRY       EC 3.4.13.3
NAME        X-His dipeptidase
            Aminoacylhistidine dipeptidase
            Carnosinase
            Homocarnosinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Xaa-|-His dipeptides
SUBSTRATE   Dipeptide
            H2O
            N-Aminoacyl-L-histidine
PRODUCT     beta-Alanine
            L-Histidine
            Amino acid
INHIBITOR   Metal chelating agent
COFACTOR    Zinc
            Manganese
EFFECTOR    Thiol
COMMENT     A mammalian cytosolic enzyme that also acts on acserine and
            homocarnosine (but not on homoanserine), and to a lesser extent on
            some other aminoacyl-L-histidine dipeptides. Activated by thioles;
            inhibited by metal-chelating agents. This enzyme may be identical
            with cytosol nonspecific dipeptidase, EC 3.4.13.18. Formerly
            EC 3.4.3.3 and 3.4.13.13.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       ECO: b0237(pepD)
            ECE: Z0298(pepD)
            ECS: ECs0264
            YPE: YPO3230(pepD)
            HIN: HI0675(pepD)
            PMU: PM1368(pepD)
            VCH: VC2279
            BBU: BB0608(pepD)
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.3
            ExPASy - ENZYME nomenclature database: 3.4.13.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.3
            BRENDA, the Enzyme Database: 3.4.13.3
///
ENTRY       EC 3.4.13.4
NAME        X-Arg dipeptidase
            Aminoacyl-lysine dipeptidase
            N2-(4-Aminobutyryl)-L-lysine hydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Preferential hydrolysis of Xaa-|-Arg, Xaa-|-Lys or Xaa-|-ornithine
            dipeptides.
SUBSTRATE   Xaa-Arg
            Xaa-Lys
            Xaa-ornithine
            H2O
PRODUCT     Amino acid
            L-Arginine
            L-Lysine
            L-Ornithine
COMMENT     Widely distributed in mammals.
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.4
            ExPASy - ENZYME nomenclature database: 3.4.13.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.4
            BRENDA, the Enzyme Database: 3.4.13.4
///
ENTRY       EC 3.4.13.5
NAME        X-Methyl-His dipeptidase
            Anserinase
            Aminoacyl-methylhistidine dipeptidase
            Acetylhistidine deacetylase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of anserine (beta-alanyl-N(pai)-methyl-L-histidine),
            carnosine, homocarnosine, glycyl-leucine and other dipeptides with
            broad specificity.
SUBSTRATE   beta-Alanyl-N(pai)-methyl-L-histidine
            Carnosine
            Homocarnosine
            Glycyl-leucine
            Dipeptide
            H2O
PRODUCT     beta-Alanine
            N(pai)-Methyl-L-histidine
            L-Histidine
            4-Aminobutylate
            Glycine
            L-Leucine
            Amino acid
COMMENT     Is identical with acetylhistidine deacetylase (formerly
            EC 3.5.1.34). formerly EC 3.4.3.4.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.5
            ExPASy - ENZYME nomenclature database: 3.4.13.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.5
            BRENDA, the Enzyme Database: 3.4.13.5
///
ENTRY       EC 3.4.13.6
NAME        Cys-Gly dipeptidase
            Cysteinylglycinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of the Cys-|-Gly dipeptide.
SUBSTRATE   Cys-Gly
            H2O
PRODUCT     L-Cysteine
            Glycine
COFACTOR    Manganese
COMMENT     A Mn2+-activated enzyme present in virtually all tissues other
            than nervous tissue. Cys-Gly is also hydrolysed by EC 3.4.11.2.
            Formerly EC 3.4.3.5.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.6
            ExPASy - ENZYME nomenclature database: 3.4.13.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.6
            BRENDA, the Enzyme Database: 3.4.13.6
///
ENTRY       EC 3.4.13.7
NAME        Glu-Glu dipeptidase
            alpha-Glutamyl-glutamate dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Glu-|-Glu dipeptide.
SUBSTRATE   Glu-Glu
            H2O
PRODUCT     L-Glutamate
COMMENT     It is unclear whether the specificity of this enzyme extends to
            other alpha-glutamyl dipeptides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.7
            ExPASy - ENZYME nomenclature database: 3.4.13.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.7
            BRENDA, the Enzyme Database: 3.4.13.7
///
ENTRY       EC 3.4.13.8
NAME        Pro-X dipeptidase
            Prolyl dipeptidase
            Iminodipeptidase
            Prolinase
            Prolylglycine dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Preferential hydrolysis of Pro-|-Xaa dipeptides; also acts on
            hydroxyprolyl analogues.
SUBSTRATE   Pro-Xaa
            H2O
            Hydroxypro-Xaa
PRODUCT     L-Proline
            Amino acid
            4-Hydroxy-L-proline
COMMENT     Prolyl amino acids are also hydrolysed by cytosol nonspecific
            dipeptidase, EC 3.4.13.18. Earlier reports of action on
            prolyl aminoacyl amides are now attributed to contamination by
            prolyl aminopeptidase. Formerly EC 3.4.3.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.8
            ExPASy - ENZYME nomenclature database: 3.4.13.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.8
            BRENDA, the Enzyme Database: 3.4.13.8
///
ENTRY       EC 3.4.13.9
NAME        X-Pro dipeptidase
            Prolidasese
            Imidodipeptidase
            Proline dipeptidase
            Peptidase D
            gamma-Peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-
            hydroxyproline analogues. No action on Pro-Pro
SUBSTRATE   Dipeptide (Xaa-Pro)
            H2O
PRODUCT     Amino acid
            L-Proline
COFACTOR    Manganese
EFFECTOR    Thiol
COMMENT     A Mn2+-activated enzyme, possibly thiol dependent, cytosolic from
            most animal tissues. Formerly EC 3.4.3.7.
GENES       ECO: b3847(pepQ)
            ECE: Z5369(pepQ)
            ECS: ECs4775
            YPE: YPO3765(pepQ)
            XFA: XF0220
            PAE: PA4498
            BSU: BG13326(ykvY)
            BHA: BH3179(pepQ)
            SAU: SA1530
            SAV: SAV1694
            LLA: L96847(pepQ)
            SPY: SPy0513(pepQ)
            SPN: SP1591
            SPR: spr1445(pepQ)
            CAC: CAC2788
            BBU: BB0430(pepQ)
            DRA: DR1246
            TMA: TM1713
            TAC: Ta1037
            TVO: TVG0545002
            PHO: PH1149
            PAB: PAB1637(pepQ-2)
            APE: APE0526
            SSO: SSO0363(pepQ)
            DME: CG5663
            HSA: 5184(PEPD)
DISEASE     MIM: 170100  Peptidase D (prolidase)
MOTIF       PS: PS00491  [HA]-[GSYR]-[LIVMT]-[SG]-H-x-[LIV]-G-[LIVM]-x-[IV]-H-
                         [DE]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.9
            ExPASy - ENZYME nomenclature database: 3.4.13.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.9
            BRENDA, the Enzyme Database: 3.4.13.9
///
ENTRY       EC 3.4.13.10
NAME        Transferred to EC 3.4.19.5
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now EC 3.4.19.5 - beta-Aspartyl-peptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.10
            ExPASy - ENZYME nomenclature database: 3.4.13.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.10
///
ENTRY       EC 3.4.13.11
NAME        Transferred to EC 3.4.13.18 and 3.4.13.19
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now included in EC 3.4.13.18 - Cytosol
            nonspecific dipeptidase, and 3.4.13.19 - Membrane dipeptidase.
GENES       MMU: 94917(Dpep1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.11
            ExPASy - ENZYME nomenclature database: 3.4.13.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.11
///
ENTRY       EC 3.4.13.12
NAME        Met-X dipeptidase
            Methionyl dipeptidase
            Dipeptidase M
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Met-|-Xaa dipeptide.
SUBSTRATE   Met-Xaa
            H2O
PRODUCT     L-Methionine
            Amino acid
COFACTOR    Manganese
COMMENT     A Mn2+-activated E. coli enzyme with thiol dependence.
PATHWAY     PATH: MAP00271  Methionine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.12
            ExPASy - ENZYME nomenclature database: 3.4.13.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.12
            BRENDA, the Enzyme Database: 3.4.13.12
///
ENTRY       EC 3.4.13.13
NAME        Transferred to EC 3.4.13.3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now included with EC 3.4.13.3 - X-His
            dipeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.13
            ExPASy - ENZYME nomenclature database: 3.4.13.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.13
            BRENDA, the Enzyme Database: 3.4.13.13
///
ENTRY       EC 3.4.13.14
NAME        Deleted entry
            gamma-Glutamyldipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.14
            ExPASy - ENZYME nomenclature database: 3.4.13.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.14
///
ENTRY       EC 3.4.13.15
NAME        Transferred to EC 3.4.13.18
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Transferred entry. Now included with EC 3.4.13.18 - Cytosol
            nonspecific dipeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.15
            ExPASy - ENZYME nomenclature database: 3.4.13.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.15
///
ENTRY       EC 3.4.13.16
NAME        Deleted entry
            Aspartylphenylalanine dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
COMMENT     Deleted entry.
STRUCTURES  PDB: 2BPV  2BPW  2BPX  2BPY  2BPZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.16
            ExPASy - ENZYME nomenclature database: 3.4.13.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.16
            SCOP (Structural Classification of Proteins): 3.4.13.16
///
ENTRY       EC 3.4.13.17
NAME        Non-stereospecific dipeptidase
            Peptidyl-D-amino acid hydrolase
            D-(or L-)Aminoacyl-dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of dipeptides containing either D- or L-amino acids or
            both.
SUBSTRATE   Dipeptide
            H2O
PRODUCT     Amino acid
COMMENT     A digestive enzyme of cephalopods.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.17
            ExPASy - ENZYME nomenclature database: 3.4.13.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.17
///
ENTRY       EC 3.4.13.18
NAME        Cytosol non-specific dipeptidase
            Peptidase A
            Glycyl-glycine dipeptidase
            Glycyl-leucine dipeptidase
            N2-beta-Alanylarginine dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of dipeptides. Hydrophobic dipeptides are cleaved
            preferentially, including prolyl amino acids.
SUBSTRATE   Dipeptide
            H2O
PRODUCT     Amino acid
INHIBITOR   Bestatin
            L-Leucine
COFACTOR    Zinc
EFFECTOR    Dithiothreitol
            Manganese
COMMENT     A zinc enzyme with broad specificity, varying somewhat with
            source species. Activated and stabilized by dithiothreitol and
            Mn2+. Inhibited by bestatin and leucine. Found in bacteria
            (Mycobacterium phlei, E. coli, Streptococcus thermophilus),
            yeast, mouse ascites tumor, rat liver and pig kidney, and pid
            and monkey intestinal mucosa. Formerly EC 3.4.3.1, 3.4.3.2,
            3.4.13.1, 3.4.13.2, 3.4.13.11 and 3.4.13.15.
GENES       LLA: L324(pepDB)
            SPY: SPy0713(pepD)
            HSA: 5181(PEPA) 5183(PEPC)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.18
            ExPASy - ENZYME nomenclature database: 3.4.13.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.18
            BRENDA, the Enzyme Database: 3.4.13.18
///
ENTRY       EC 3.4.13.19
NAME        Membrane dipeptidase
            Renal dipeptidase
            Dehydropeptidase I (DPH I)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of dipeptides
SUBSTRATE   Dipeptide
            H2O
PRODUCT     Amino acid
INHIBITOR   Bestatin
            Cilastatin
COFACTOR    Zinc
COMMENT     A membrane-bound, zinc enzyme with broad specificity. Abundant in
            the kidney cortex. Inhibited by bestatin and cilastatin.
            Formerly EC 3.4.13.11.
GENES       SSO: SSO1864
            STO: ST1063
            MMU: 94917(Dpep1)
            HSA: 1800(DPEP1)
DISEASE     MIM: 179780  Dipeptidase-1, renal
MOTIF       PS: PS00869  [LIVM]-E-G-[GA]-x(2)-[LIVMF]-x(6)-L-x(3)-Y-x(2)-G-
                         [LIVM]-R
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.19
            ExPASy - ENZYME nomenclature database: 3.4.13.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.19
            BRENDA, the Enzyme Database: 3.4.13.19
///
ENTRY       EC 3.4.13.20
NAME        beta-Ala-His dipeptidase
            Serum carnosinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Preferential hydrolysis of the beta-Ala-|-His dipeptide
            (carnosine), and also anserine, Xaa-|-His dipeptides and other
            dipeptides including homocarnosine.
SUBSTRATE   Carnosine
            beta-Alanyl-N(pai)-methyl-L-histidine
            Xaa-His
            Homocarnosine
            H2O
PRODUCT     beta-Alanine
            L-Histidine
            N(pai)-Methyl-L-histidine
            Amino acid
            4-Aminobutylate
COFACTOR    Cadmium
            Citrate
COMMENT     Present in the serun of humans and higher primates, but not in the
            serum of other mammals. Activated by Cd2+ and citrate.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.13.20
            ExPASy - ENZYME nomenclature database: 3.4.13.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.20
            BRENDA, the Enzyme Database: 3.4.13.20
///
ENTRY       EC 3.4.14.1
NAME        Dipeptidyl-peptidase I
            Cathepsin C
            Dipeptidyl aminopeptidase I
            Dipeptidyl transferase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc-, except when Xaa
            is Arg or Lys, or Xbb or Xcc is Pro
SUBSTRATE   Peptide
            H2O
PRODUCT     Dipeptide
            Polypeptide
EFFECTOR    Chloride
COMMENT     A Cl--dependent, lysosomal cysteine-type peptidase maximally
            activate at acidic pH. Also polymerizes dipeptide amides,
            arylamides and esters at neutral pH. Formerly EC 3.4.4.9.
GENES       HSA: 1075(CTSC)
DISEASE     MIM: 602365  Cathepsin C
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.1
            ExPASy - ENZYME nomenclature database: 3.4.14.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.1
            BRENDA, the Enzyme Database: 3.4.14.1
///
ENTRY       EC 3.4.14.2
NAME        Dipeptidyl-peptidase II
            Dipeptidyl aminopeptidase II
            Dipeptidyl arylamidase II
            Carboxytripeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide, Xaa-Xbb+, preferentially when
            Xbb is Als or Pro. substrates are oligopeptides, preferentially
            tripeptides.
SUBSTRATE   Tripeptide
            H2O
PRODUCT     Dipeptide
            Amino acid
COMMENT     A lysosomal serine-type peptidase maximally active at acidic pH.
GENES       HSA: 29952(DPP7)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.2
            ExPASy - ENZYME nomenclature database: 3.4.14.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.2
            BRENDA, the Enzyme Database: 3.4.14.2
///
ENTRY       EC 3.4.14.3
NAME        Transferred to EC 3.4.19.1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
COMMENT     Transferred entry. Now EC 3.4.19.1 - Acylaminoacyl-peptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.3
            ExPASy - ENZYME nomenclature database: 3.4.14.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.3
///
ENTRY       EC 3.4.14.4
NAME        Dipeptidyl peptidase III
            Dipeptidyl aminopeptidase III
            Dipeptidyl arylamidase III
            Red cell angiotensinase
            Enkephalinase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide from a peptide of four or more
            residues, with broad specificity.
SUBSTRATE   Peptide
            H2O
PRODUCT     Dipeptide
            Peptide
COMMENT     A cytosolic serine-type peptidase active at neutral pH. Highly
            selective for Arg-Arg-2-naphthylamide at pH 9.2. Inactive on
            (Glu)4, (Gly)4, and tripeptides, as well as bonds involving
            proline.
GENES       HSA: 10072(DPP3)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.4
            ExPASy - ENZYME nomenclature database: 3.4.14.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.4
            BRENDA, the Enzyme Database: 3.4.14.4
///
ENTRY       EC 3.4.14.5
NAME        Dipeptidyl-peptidase IV
            Dipeptidyl aminopeptidase IV
            Xaa-Pro-dipeptidyl-aminopeptidase
            Gly-Pro naphthylamidase
            Postproline dipeptidyl aminopeptidase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide, Xaa-Xbb-|-Xcc, from a
            polypeptide, preferentially when Xbb is Pro, provided Xcc is
            neither Pro nor hydroxyproline
SUBSTRATE   Peptide
            H2O
PRODUCT     Dipeptide
            Polypeptide
INHIBITOR   L-Pro-L-boroPro
COMMENT     A membrane-bound serine-type peptidase in mammals and
            flavobacteria.
            Inhibited L-Pro-L-boroPro ( W.G.Gutheil and W.W.Bachovchin,
            Biochemistry, 32, 8723-8731 (1993) ).
GENES       CEL: T23F1.7b
            DME: CG11034
            MMU: 94919(Dpp4)
            HSA: 1803(DPP4)
DISEASE     MIM: 102720  Dipeptidylpeptidase IV (CD26; adenosine deaminase
                         complexing
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.5
            ExPASy - ENZYME nomenclature database: 3.4.14.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.5
            BRENDA, the Enzyme Database: 3.4.14.5
///
ENTRY       EC 3.4.14.6
NAME        Dipeptidyl-dipeptidase
            Dipeptidyl tetrapeptide hydrolase
            Dipeptidyl ligase
            Tetrapeptide dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Preferential release of dipeptides from a tetrapeptide, e.g.
            Ala-Gly-|-Ala-Gly. Acts more slowly on Ala-Ala-|-Ala-Ala and
            Gly-Gly-|-Gly-Gly.
SUBSTRATE   Tetrapeptide
            H2O
PRODUCT     Dipeptide
COMMENT     A thiol-activated peptidase from cabbage (Brassica oleracea).
            Tetrapeptides are formed from Ala-Ala, Gly-Gly, Ala-Gly and
            Gly-Ala.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.6
            ExPASy - ENZYME nomenclature database: 3.4.14.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.6
            BRENDA, the Enzyme Database: 3.4.14.6
///
ENTRY       EC 3.4.14.7
NAME        Deleted entry
            Tetralysine endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.7
            ExPASy - ENZYME nomenclature database: 3.4.14.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.7
///
ENTRY       EC 3.4.14.8
NAME        Transferred to EC 3.4.14.9 and 3.4.14.10
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
COMMENT     Transferred entry. Now EC 3.4.14.9 - Tripeptidyl-peptidase I and
            EC 3.4.14.10 - Tripeptidyl-peptidase II.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.8
            ExPASy - ENZYME nomenclature database: 3.4.14.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.8
///
ENTRY       EC 3.4.14.9
NAME        Tripeptidyl-peptidase I
            Tripeptidyl aminopeptidase
            Tripeptidyl peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal tripeptide from a polypeptide
SUBSTRATE   Peptide
            H2O
PRODUCT     Tripeptide
            Peptide
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     A lysosomal enzyme active at acidic pH. Inhibited by diisopropyl
            fluorophosphate. Formerly included in EC 3.4.14.8.
GENES       HSA: 1200(CLN2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.9
            ExPASy - ENZYME nomenclature database: 3.4.14.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.9
            BRENDA, the Enzyme Database: 3.4.14.9
///
ENTRY       EC 3.4.14.10
NAME        Tripeptidyl-peptidase II
            Tripeptidyl aminopeptidase
            Tripeptidyl peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal tripeptide from a polypeptide
SUBSTRATE   Polypeptide
            H2O
PRODUCT     Tripeptide
            Polypeptide
COMMENT     A cytosolic enzyme active at neutral pH. Inhibited by diisopropyl
            fluorophosphate. Formerly included in EC 3.4.14.8.
GENES       SPO: SPAP8A3.12C(spap8a3.12c)
            ATH: At4g20850(T13K14.10)
            CEL: F21H12.6
            DME: CG3991(TppII)
            MMU: 102724(Tpp2)
            HSA: 7174(TPP2)
DISEASE     MIM: 190470  Tripeptidyl peptidase II
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.10
            ExPASy - ENZYME nomenclature database: 3.4.14.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.10
            BRENDA, the Enzyme Database: 3.4.14.10
///
ENTRY       EC 3.4.14.11
NAME        Xaa-Pro dipeptidyl-peptidase
            X-Pro dipeptidyl-peptidase
            X-Prolyl dipeptidyl aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Cleavages Xaa-Pro-|- bonds to release unblocked, N-Terminal
            dipeptides from substrates including Ala-Pro-|-p-Nitroanilide and
            Tyr-Pro-|-Phe-Pro-Gly-Pro-Ile
COMMENT     EC 3.4.14.5 catalyzes a similar reaction.
            Belongs to peptidase family S15.
GENES       LLA: L118079(pepXP)
            SPY: SPy1858(pepXP)
            SPN: SP0894
            SPR: spr0794(pepXP)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.14.11
            ExPASy - ENZYME nomenclature database: 3.4.14.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.11
            BRENDA, the Enzyme Database: 3.4.14.11
///
ENTRY       EC 3.4.15.1
NAME        Peptidyl dipeptidase A
            Angiotensin I-converting enzyme
            Kininase II
            Dipeptidyl carboxypeptidase I
            Peptidase P
            Carboxycathepsin
            Dipeptide hydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
REACTION    Release of a C-terminal dipeptide, -Xaa-|-Xbb-Xcc, when neither Xaa
            nor Xbb is Pro. Thus, conversion of angiotensin I to angiotensin
            II
SUBSTRATE   Peptide
            Angiotensin I
            Bradykinin
            H2O
PRODUCT     Peptide
            Dipeptide
            Angiotensin II
INHIBITOR   (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]glycine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]-(S)-alanine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]glycine
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]-(S)-alanine
COFACTOR    Zinc
EFFECTOR    Chloride
COMMENT     A Cl--dependent, zinc glycoprotein that is generally membrane-
            -bound. Active at neutral pH. Only single dipeptides are
            released from angiotensin I and bradykinin because of the lack of
            activity on bonds involving proline. May also have endopeptidase
            activity on some substrates. The enzyme from E. coli was
            formerly EC 3.4.15.3.
GENES       SME: SMc04403(dcp)
            DME: CG10593(Acer) CG8827(Ance)
            MMU: 87874(Ace)
            HSA: 1636(ACE)
DISEASE     MIM: 106180  Dipeptidyl carboxypeptidase-1 (angiotensin I
                         converting enzyme)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1DTD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.15.1
            ExPASy - ENZYME nomenclature database: 3.4.15.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.1
            BRENDA, the Enzyme Database: 3.4.15.1
            SCOP (Structural Classification of Proteins): 3.4.15.1
///
ENTRY       EC 3.4.15.2
NAME        Transferred to EC 3.4.19.2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
COMMENT     Transferred entry. Now EC 3.4.19.2 - Peptidyl-glycinamidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.15.2
            ExPASy - ENZYME nomenclature database: 3.4.15.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.2
///
ENTRY       EC 3.4.15.3
NAME        Transferred to EC 3.4.15.1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
COMMENT     Transferred entry. Now included with EC 3.4.15.1 - Peptidyl-
            $dipeptidase A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.15.3
            ExPASy - ENZYME nomenclature database: 3.4.15.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.3
            BRENDA, the Enzyme Database: 3.4.15.3
///
ENTRY       EC 3.4.15.4
NAME        Peptidyl-dipeptidase B
            Dipeptidyl carboxyhydrolase
            Atriopeptin convertase
            Atrial di-(tri-)peptidyl carboxyhydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
REACTION    Release of C-terminal dipeptide or exceptionally a tripeptide.
SUBSTRATE   Peptide
            H2O
            Artiopeptin III
PRODUCT     Dipeptide
            Peptide
            Artiopeptin I
COFACTOR    Zinc
COMMENT     A membrane-bound, zinc metallopeptidase located in mammalian
            atrial, but not ventricular, myocytes. Although it is capable of
            converting the 126-residue atriopeptin III directly to atriopeptin
            I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is
            generally restricted to the release of dipeptides. In contrast to
            peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence
            and shows no action on angiotensin I. Conversely, peptidyl-
            -dipeptidase A is unable to release Phe-Arg from C-terminus of
            atriopeptin II.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.15.4
            ExPASy - ENZYME nomenclature database: 3.4.15.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.4
            BRENDA, the Enzyme Database: 3.4.15.4
///
ENTRY       EC 3.4.15.5
NAME        Peptidyl-dipeptidase DCP
            Dipeptidyl carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
REACTION    Hydrolysis of unblocked, C-Terminal dipeptides from Oligopeptides,
            with broad specificity. Does not hydrolyse bonds in which P1' is
            Pro, or both P1 and P1' are Gly.
COMMENT     Known from E.coli and S.typhimurium.
            Inhibited by Captopril, as is Peptidyl-dipeptidase A.
            Belongs to peptidase family M3.
GENES       ECO: b1538(dcp)
            ECE: Z2160(dcp)
            ECS: ECs2147
            XFA: XF1944
            MLO: mlr4139
            CCR: CC3702
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.15.5
            ExPASy - ENZYME nomenclature database: 3.4.15.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.5
            BRENDA, the Enzyme Database: 3.4.15.5
///
ENTRY       EC 3.4.16.1
NAME        Transferred to EC 3.4.16.5 and 3.4.16.6
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
COMMENT     Transferred entry. Now included in EC 3.4.16.5 and 3.4.16.6.
            Carboxypeptidase of broad specificity with optimum pH 4.5-6.0,
            inhibited by diisopropyl fluorophosphate, and sensitive to thiol-
            -blocking reagents. Sources include microorganisms: Penicillium
            (S1, S2, P), yeast (carboxypeptidase Y, yeast protease C,
            carboxypeptidase C), Aspergillus; higher plants: citrus
            (carboxypeptidase C), germinating barley, germinating wheat
            (serine carboxypeptidase II), germinating cotton, beans
            (phaseolin); higher animals: lysosomal carboxypeptidase A
            (cathepsin A). Not identical with serine-type endopeptidases.
            Formerly EC 3.4.12.1 and 3.4.21.13. This enzyme is probably also
            identical to lysosomal tyrosine carboxypeptidase, formerly EC
            3.4.16.3.
STRUCTURES  PDB: 3SC2  1WHS  1WHT  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.1
            ExPASy - ENZYME nomenclature database: 3.4.16.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.1
            SCOP (Structural Classification of Proteins): 3.4.16.1
///
ENTRY       EC 3.4.16.2
NAME        Lysine Pro-X carboxypeptidase
            Angiotensinase C
            Lysosomal carboxypeptidase C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
REACTION    Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     A lysosomal peptidase active at acidic pH that inactivates
            angiotensin II. Inhibited by diisopropyl fluorophosphate.
            Formerly EC 3.4.12.4.
GENES       HSA: 5547(PRCP)
DISEASE     MIM: 176785  Prolylcarboxypeptidase (angiotensinase C)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.2
            ExPASy - ENZYME nomenclature database: 3.4.16.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.2
            BRENDA, the Enzyme Database: 3.4.16.2
///
ENTRY       EC 3.4.16.3
NAME        Transferred to EC 3.4.16.5
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
COMMENT     Transferred entry. Now included with EC 3.4.16.5 - Serine-type
            carboxypeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.3
            ExPASy - ENZYME nomenclature database: 3.4.16.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.3
///
ENTRY       EC 3.4.16.4
NAME        Serine-type D-Ala-D-Ala carboxypeptidase
            DD-Peptidase
            D-Alanyl-D-alanine carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
REACTION    Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also
            transpeptidation of peptidyl-alanyl moieties that are N-acyl
            substituents of D-alanine
SUBSTRATE   Peptide
            H2O
            (Ac)2-L-Lys-D-Ala-D-Ala
PRODUCT     D-Alanine
            Peptide
            (Ac)2-L-Lys-D-Ala
INHIBITOR   Penicillin
            beta-Lactam antibiotics
COMMENT     A membrane-bound, bacterial enzyme inhibited by penicillin and
            other beta-lactam antibiotics, which acylate the active site
            serine. Distinct from zinc D-Ala-D-Ala carboxypeptidase,
            EC 3.4.17.14.
GENES       ECO: b0632(dacA) b0839(dacC) b2010(dacD)
            ECE: Z0777(dacA) Z1066(dacC) Z3171(dacD)
            ECS: ECs0670 ECs0919 ECs2812
            YPE: YPO1320(dacC) YPO2601(dacA) YPO3506(dacB)
            HIN: HI0029(dacA)
            PMU: PM1927(dacA)
            XFA: XF1614 XF2230
            VCH: VC0947 VCA0270
            PAE: PA3047 PA3999(dacC)
            NME: NMB0877 NMB1797
            NMA: NMA0665 NMA1095
            RPR: RP389(dacF)
            RCO: RC0536(dacF)
            MLO: mll0426 mll3581 mlr0666 mlr4960
            SME: SMc01188(dac)
            CCR: CC2161
            BSU: BG10074(dacA) BG10295(dacF) BG10527(dacB)
            BHA: BH0021(dacA) BH1535(dacF) BH1573 BH2877(dacB)
            SAU: SA0598(pbp4)
            SAV: SAV0630(pbp4)
            LLA: L139168(dacA)
            SPY: SPy0292(dacA) SPy1093
            SPN: SP0872
            SPR: spr0776(dacA)
            CAC: CAC0993(dacF) CAC1267(dacB) CAC2057 CAC2063(dacF)
            MTU: Rv2911(dacB) Rv3330 Rv3627c
            MTC: MT2979 MT3433 MT3729
            MLE: ML0211 ML0691
            CTR: CT551
            CMU: TC0839
            CPN: CPn0672
            CPA: CP0075
            CPJ: dacF
            BBU: BB0582 BB0605(dacA)
            TPA: TP0221 TP0800
            SYN: slr0646(dacB) slr0804(dacB) slr1924
            DRA: DR0176
STRUCTURES  PDB: 1ESI  1CEF  1CEG  1ES2  1ES3  1ES4  1ES5  1J9M  1HVB  1SKF  
                 2PTE  3PTE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.4
            ExPASy - ENZYME nomenclature database: 3.4.16.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.4
            BRENDA, the Enzyme Database: 3.4.16.4
            SCOP (Structural Classification of Proteins): 3.4.16.4
///
ENTRY       EC 3.4.16.5
NAME        Carboxypeptidase C
            Serine-type carboxypeptidase I
            Cathespin A
            Carboxypeptidase Y
            Lysosomal protective protein
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
REACTION    Release of a C-terminal amino acid with a broad specificity.
INHIBITOR   Diisopropyl fluorophosphate
            Thiol-blocking reagent
COMMENT     Carboxypeptidases of broad specificity with optimum PH 4.5-6.0,
            inhibited by the action of Diisopropul fluorophosphate, and
            sensitive to thiol-blocking reagents.
            This enzyme is probably also identical to Lysosomal tyrosine
            Carboxypeptidase.
            Belongs to peptidase family S10.
GENES       SCE: YMR297W(PRC1)
            MMU: 97748(Ppgb)
            HSA: 5476(PPGB)
DISEASE     MIM: 256540  Protective protein for beta-galactosidase (cathepsin
                         A)
MOTIF       PS: PS00131  [LIVM]-x-[GTA]-E-S-Y-[AG]-[GS]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00560  [LIVF]-x(2)-[LIVSTA]-x-[IVPST]-x-[GSDNQL]-[SAGV]-[SG]-
                         H-x-[IVAQ]-P-x(3)-[PSA]
STRUCTURES  PDB: 1CPY  1IVY  1YSC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.5
            ExPASy - ENZYME nomenclature database: 3.4.16.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.5
            BRENDA, the Enzyme Database: 3.4.16.5
            SCOP (Structural Classification of Proteins): 3.4.16.5
///
ENTRY       EC 3.4.16.6
NAME        Carboxypeptidase D
            Carboxypeptidase KEX1
            Carboxypeptidase S1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine-type carboxypeptidases
REACTION    Preferential release of a C-terminal arginine or lysine residue.
INHIBITOR   Diisopropyl fluorophosphate
            Thiol-blocking reagent
COMMENT     Carboxypeptidases of broad specificity with optimum PH 4.5-6.0,
            inhibited by the action of Diisopropyl fluorophosphate, and
            sensitive to thiol-clocking reagents.
            Belongs to peptodase family S10.
GENES       SCE: YGL203C(KEX1)
MOTIF       PS: PS00131  [LIVM]-x-[GTA]-E-S-Y-[AG]-[GS]
            PS: PS00560  [LIVF]-x(2)-[LIVSTA]-x-[IVPST]-x-[GSDNQL]-[SAGV]-[SG]-
                         H-x-[IVAQ]-P-x(3)-[PSA]
STRUCTURES  PDB: 1BCS  1AC5  1BCR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.16.6
            ExPASy - ENZYME nomenclature database: 3.4.16.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.16.6
            BRENDA, the Enzyme Database: 3.4.16.6
            SCOP (Structural Classification of Proteins): 3.4.16.6
///
ENTRY       EC 3.4.17.1
NAME        Carboxypeptidase A
            Carboxypolypeptidase
            Pancreatic carboxypeptidase A
            Tissue carboxypeptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal amino acid, but little or no action with
            -Asp, -Glu, -Arg, -Lys or -Pro
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
            Amino acid
COFACTOR    Zinc
COMMENT     A zinc enzyme formed from procarboxypeptidase A. Isolated from
            cattle, pig and dogfish pancreas, and other sources including mast
            cells and skeletal muscle. Formerly EC 3.4.2.1 and 3.4.12.2.
GENES       MMU: 88479(Cpa3)
            HSA: 1357(CPA1) 1359(CPA3)
DISEASE     MIM: 114850  Carboxypeptidase A
            MIM: 114851  Carboxypeptidase A3, mast cell
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
STRUCTURES  PDB: 1BAV  1ARL  1ARM  3CPA  1CBX  1CPS  1CPX  1F57  1PYT  1YME  
                 2CTB  2CTC  4CPA  5CPA  6CPA  7CPA  8CPA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.1
            ExPASy - ENZYME nomenclature database: 3.4.17.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.1
            BRENDA, the Enzyme Database: 3.4.17.1
            SCOP (Structural Classification of Proteins): 3.4.17.1
///
ENTRY       EC 3.4.17.2
NAME        Carboxypeptidase B
            Protaminase
            Pancreatic carboxypeptidase B
            Tissue carboxypeptidase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Preferential release of a C-terminal lysine or arginine amino acid
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            Peptide
            H2O
PRODUCT     Peptide
            L-Lysine
            L-Arginine
COFACTOR    Zinc
COMMENT     A zinc enzyme formed from procarboxypeptidase B. Isolated from
            cattle, pig and dogfish pancreas and other sources, including skin
            fibroblasts and adrenal medulla. Formerly EC 3.4.2.2 and 3.4.12.3.
GENES       HSA: 1360(CPB1)
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
STRUCTURES  PDB: 1PBA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.2
            ExPASy - ENZYME nomenclature database: 3.4.17.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.2
            BRENDA, the Enzyme Database: 3.4.17.2
            SCOP (Structural Classification of Proteins): 3.4.17.2
///
ENTRY       EC 3.4.17.3
NAME        Lysine carboxypeptidase
            Carboxypeptidase N
            Arginine carboxypeptidase
            Kininase I
            Anaphylatoxin inactivator
            Plasma carboxypeptidase B
            Creatine kinase conversion factor
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal basic amino acid, preferentially lysine
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            H2O
            Peptide
            Bradykinin
            Anaphylatoxin
PRODUCT     Peptide
            L-Lysine
            L-Arginine
            Inactivated bradykinin
            Inactivated anaphylatoxin
COFACTOR    Zinc
COMMENT     A zinc enzyme found in plasma. Inactivates bradykinin and
            anaphylatoxins in blood plasma. Formerly EC 3.4.12.7.
GENES       DME: CG4122(svr) CG4122_1(svr)
            HSA: 1369(CPN1) 1370(CPN2)
DISEASE     MIM: 603103  Carboxypeptidase N, polypeptide 1, 50-kD
            MIM: 603104  Carboxypeptidase N, polypeptide 2, 83-KD
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.3
            ExPASy - ENZYME nomenclature database: 3.4.17.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.3
            BRENDA, the Enzyme Database: 3.4.17.3
///
ENTRY       EC 3.4.17.4
NAME        Gly-X carboxypeptidase
            Glycine carboxypeptidase
            Carboxypeptidase a
            Carboxypeptidase S
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal amino acid from a peptide in which glycine
            is the penultimate amino acid, e.g. Z-Gly-|-Leu
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
            Amino acid
COMMENT     From yeast. Formerly EC 3.4.2.3, 3.4.12.8 and 3.4.17.9.
GENES       SCE: YJL172W(CPS1)
            SPO: SPAC24C9.08(spac24c9.08)
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.4
            ExPASy - ENZYME nomenclature database: 3.4.17.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.4
            BRENDA, the Enzyme Database: 3.4.17.4
///
ENTRY       EC 3.4.17.5
NAME        Deleted entry
            Aspartate carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.5
            ExPASy - ENZYME nomenclature database: 3.4.17.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.5
///
ENTRY       EC 3.4.17.6
NAME        Alanine carboxypeptidase
            N-Benzoyl-L-alanine-amidohydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal alanine from a peptide or a variety of
            pteroyl or acyl groups
SUBSTRATE   Peptidyl-L-alanine
            Peptide
            H2O
PRODUCT     Peptide
            L-Alanine
COMMENT     From soil bacteria. The enzyme from Corynebacterium equi also
            hydrolyses N-benzoylglycine and N-benzoyl-L-aminobutyric acid.
            Formerly EC 3.4.12.11.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.6
            ExPASy - ENZYME nomenclature database: 3.4.17.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.6
            BRENDA, the Enzyme Database: 3.4.17.6
///
ENTRY       EC 3.4.17.7
NAME        Transferred to EC 3.5.1.28
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
COMMENT     Transferred entry. Now EC 3.5.1.28 - N-Acetylmuramoyl-L-alanine
            amidase
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.7
            ExPASy - ENZYME nomenclature database: 3.4.17.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.7
///
ENTRY       EC 3.4.17.8
NAME        Muramoylpentapeptide carboxypeptidase
            D-Alanine carboxypeptidase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Cleavage of the bond: UDP-N-acetylmuramoyl-L-alanyl-D-gamma-
            -glutamyl-6-carboxy-L-lysyl-D-alanyl-|-D-alanine
SUBSTRATE   UDP-N-acetylmuramoyl-L-Ala-D-gamma-Glu-6-carboxy-L-Lys-(D-Ala)2
            H2O
PRODUCT     UDP-N-acetylmuramoyl-L-Ala-D-gamma-Glu-6-carboxy-L-Lys-D-Ala
            D-Alanine
INHIBITOR   Penicillin
            Cephalosporin
EFFECTOR    Divalent metal
COMMENT     A bacterial enzyme that requires a divalent cation for activity.
            Does not cleave the C-terminal D-alanine from the product of the
            above reaction, UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-
            -6-carboxy-L-lysyl-D-alanine. Competitively inhibited by
            penicillins and cephalosporins. Formerly EC 3.4.12.6.
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
STRUCTURES  PDB: 1LBU  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.8
            ExPASy - ENZYME nomenclature database: 3.4.17.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.8
            BRENDA, the Enzyme Database: 3.4.17.8
            SCOP (Structural Classification of Proteins): 3.4.17.8
///
ENTRY       EC 3.4.17.9
NAME        Transferred to EC 3.4.17.4
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
COMMENT     Transferred entry. Now included with EC 3.4.17.4 - Gly-X
            carboxypeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.9
            ExPASy - ENZYME nomenclature database: 3.4.17.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.9
            BRENDA, the Enzyme Database: 3.4.17.9
///
ENTRY       EC 3.4.17.10
NAME        Carboxypeptidase H
            Carboxypeptidase E
            Enkephalin convertase
            Cobalt-stimulated chromaffin granule carboxypeptidase
            Insulin granule-associated carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of C-terminal arginine or lysine residues from
            polypeptide
SUBSTRATE   Peptidyl-L-lysine
            Peptidyl-L-arginine
            Peptide
            H2O
PRODUCT     Peptide
            L-Lysine
            L-Arginine
INHIBITOR   1,10-Phenanthroline
            Chelating agents
COFACTOR    Zinc
EFFECTOR    Cobalt
COMMENT     A zinc enzyme, activated by Co2+. Inhibited by 1,10-
            phenanthroline and other chelating agents. pH optimum 5.6.
            Located in storage granules of secretory cells, and active in
            processing of protein hormones and bioactive peptides. Distinct
            from EC 3.4.17.2 and 3.4.17.3.
GENES       CEL: F01D4.4
            DME: CG4122(svr) CG4122_1(svr)
            MMU: 101932(Cpe)
            HSA: 1363(CPE)
DISEASE     MIM: 114855  Carboxypeptidase E
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.10
            ExPASy - ENZYME nomenclature database: 3.4.17.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.10
            BRENDA, the Enzyme Database: 3.4.17.10
///
ENTRY       EC 3.4.17.11
NAME        Glutamate carboxypeptidase
            Carboxypeptidase G
            Carboxypeptidase G1
            Carboxypeptidase G2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of C-terminal glutamate residues from a wide range of
            N-acylating moieties, including peptidyl, aminoacyl, benzoyl,
            benzyloxycarbonyl, folyl and pteroyl groups.
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Glutamate
            Peptide
COFACTOR    Zinc
COMMENT     A zinc enzyme produced by pseudomonads, Flavobacterium sp. and
            Acinetobacter sp. Its ability to hydrolyse pteroyl-L-glutamate
            (folic acid) has led to its use as a folate-depleting,
            antitumour agent.
GENES       PMU: PM0932
            PAE: PA2787(cpg2)
            BHA: BH0352
            DRA: DR2493
            TMA: TM0129
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
STRUCTURES  PDB: 1CG2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.11
            ExPASy - ENZYME nomenclature database: 3.4.17.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.11
            BRENDA, the Enzyme Database: 3.4.17.11
            SCOP (Structural Classification of Proteins): 3.4.17.11
///
ENTRY       EC 3.4.17.12
NAME        Carboxypeptidase M
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Cleavage of C-terminal arginine or lysine residues from
            polypeptides.
SUBSTRATE   Peptide
            H2O
PRODUCT     L-Arginine
            L-Lysine
            Peptide
COMMENT     A mambrane-bound enzyme optimally active at neutral pH.
            Distinct from EC 3.4.17.2, 3.4.17.3 and 3.4.17.10.
GENES       DME: CG4678
            HSA: 1368(CPM)
DISEASE     MIM: 114860  Carboxypeptidase M
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.12
            ExPASy - ENZYME nomenclature database: 3.4.17.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.12
            BRENDA, the Enzyme Database: 3.4.17.12
///
ENTRY       EC 3.4.17.13
NAME        Muramoyltetrapeptide carboxypeptidase
            Carboxypeptidase IIW
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-
            -L-Ala-D-glutamyl-6-carboxy-L-lysyl-|-D-alanine
SUBSTRATE   N-Acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanine
            H2O
PRODUCT     N-Acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-
            $carboxy-L-lysine
            D-Alanine
INHIBITOR   Thiol-blocking reagent
EFFECTOR    Manganese
            Calcium
COMMENT     Variants are known from various microorganisms. Involved in
            peptidoglycan synthesis, catalysing both decarboxylation and
            transpeptidation. Stimulated by divalent cations such as Mg2+
            and Ca2+, but not by Zn2+. Inhibited by thiol-blocking reagents,
            but unaffected by penicillin.
GENES       ECO: b1192
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.13
            ExPASy - ENZYME nomenclature database: 3.4.17.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.13
            BRENDA, the Enzyme Database: 3.4.17.13
///
ENTRY       EC 3.4.17.14
NAME        Zinc D-Ala-D-Ala carboxypeptidase
            Zn2+ G peptidase
            D-Alanyl-D-alanine hydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Cleavage of the bond: (Ac)2-L-lysyl-D-alanyl-|-D-alanine
SUBSTRATE   (Ac)2-L-lysyl-D-alanyl-D-alanine
            H2O
PRODUCT     (Ac)2-L-lysyl-D-alanine
            D-Alanine
EFFECTOR    Zinc
COMMENT     A zinc enzyme. Catalyses carboxypeptidation but not
            transpeptidation reactions involved in bacterial cell wall
            metabolism. Weakly inihibited by beta-lactams. Distinct from
            serine-type D-Ala-D-Ala carboxypepetidase, EC 3.4.16.4.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.14
            ExPASy - ENZYME nomenclature database: 3.4.17.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.14
            BRENDA, the Enzyme Database: 3.4.17.14
///
ENTRY       EC 3.4.17.15
NAME        Carboxypeptidase A2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Similar to that ot carboxypepetidase A (EC 3.4.17.1), but with a
            preference for bulkier C-terminal residues
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
COMMENT     Isolated from rat pancreas but not present in cattle pancreas.
            A homologue of carboxypeptidase A.
GENES       HSA: 1358(CPA2)
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
STRUCTURES  PDB: 1AYE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.15
            ExPASy - ENZYME nomenclature database: 3.4.17.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.15
            BRENDA, the Enzyme Database: 3.4.17.15
            SCOP (Structural Classification of Proteins): 3.4.17.15
///
ENTRY       EC 3.4.17.16
NAME        Membrane Pro-X carboxypeptidase
            Carboxypeptidase P
            Microsomal carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-terminal residue other than proline, by
            preferential cleavage of a prolyl bond
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
COMMENT     One of the renal brush border exopeptidases.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.16
            ExPASy - ENZYME nomenclature database: 3.4.17.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.16
            BRENDA, the Enzyme Database: 3.4.17.16
///
ENTRY       EC 3.4.17.17
NAME        Tubulinyl-Tyr carboxypeptidase
            Carboxypeptidase-tubulin
            Soluble carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Cleavage of the -Glu-|-Tyr bond to release the C-terminal tyrosine
            residue from the native tyrosinated tubulin.  Inactive on
            Z-Glu-Tyr
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     Active at neutral pH, from brain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.17
            ExPASy - ENZYME nomenclature database: 3.4.17.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.17
            BRENDA, the Enzyme Database: 3.4.17.17
///
ENTRY       EC 3.4.17.18
NAME        Carboxypeptidase T
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release a C-Terminal residue, which may be hydrophobic or positively
            charged.
COMMENT     Belongs to peptidase family M14.
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
            PS: PS00133  H-[STAG]-x(3)-[LIVME]-x(2)-[LIVMFYW]-P-[FYW]
STRUCTURES  PDB: 1OBR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.18
            ExPASy - ENZYME nomenclature database: 3.4.17.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.18
            BRENDA, the Enzyme Database: 3.4.17.18
            SCOP (Structural Classification of Proteins): 3.4.17.18
///
ENTRY       EC 3.4.17.19
NAME        Thermostable carboxypeptidase 1
            Carboxypeptidase TAQ
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of a C-Terminal Amino acid with broad specificity, expect
            for -Pro.
COMMENT     Most active at 80 degrees celsius.
            Belongs to peptidase family M32.
GENES       VCH: VC1414
            MLO: mlr3932
            BSU: BG11458(ypwA)
            BHA: BH2149
            DRA: DR2423
            HAL: VNG2616G(cxp)
            PHO: PH0465
            PAB: PAB1320
            APE: APE1775
            SSO: SSO3105
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.19
            ExPASy - ENZYME nomenclature database: 3.4.17.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.19
            BRENDA, the Enzyme Database: 3.4.17.19
///
ENTRY       EC 3.4.17.20
NAME        Carboxypeptidase U
            Arginine carboxypeptidase
            Carboxypeptidase R
            Plasma carboxypeptidase B
            Thrombin-activatable fibrinolysis inhibitor
            TAFI
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    release of C-terminal arg and lys from a polypeptide
COFACTOR    Zinc
COMMENT     Pro-carboxypeptidase U in plasma is activated by thrombin or
            plasmin during clotting to form the unstable carboxypeptidase U.
            Activity similar to that of the more stable lysine
            carboxypeptidase, except no preference is shown for Lys over Arg.
            Belongs to peptidase family M14.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.20
            ExPASy - ENZYME nomenclature database: 3.4.17.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.20
///
ENTRY       EC 3.4.17.21
NAME        Glutamate carboxypeptidase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Release of an unsubstituted, C-terminal glutamyl residue, typically
            from AC-asp-glu or pteroyl-gamma
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.21
            ExPASy - ENZYME nomenclature database: 3.4.17.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.21
///
ENTRY       EC 3.4.17.22
NAME        Metallocarboxypeptidase D
            Carboxypeptidase D
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metallocarboxypeptidases
REACTION    Releases C-terminal arg and lys from polypeptides
COFACTOR    Zinc
COMMENT     Activated by cobalt.
            Inhibited by guanidinoethylmercaptosuccinic acid.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.17.22
            ExPASy - ENZYME nomenclature database: 3.4.17.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.17.22
///
ENTRY       EC 3.4.18.1
NAME        Cysteine-type carboxypeptidase
            Lysosomal carboxypeptidase B
            Cathepsin B2
            Cathepsin IV
            Acid carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine-type carboxypeptidases
REACTION    Liberation of C-terminal amino acid residues, with broad
            specificity, but lacks action on C-terminal proline
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
COMMENT     Deaminates Z-Arg-NH2, but slows no action on the arylamide
            derivatives. Inhibited by thiol-blocking reagents.
STRUCTURES  PDB: 1EF7  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.18.1
            ExPASy - ENZYME nomenclature database: 3.4.18.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.18.1
            BRENDA, the Enzyme Database: 3.4.18.1
            SCOP (Structural Classification of Proteins): 3.4.18.1
///
ENTRY       EC 3.4.19.1
NAME        Acylaminoacyl-peptidase
            Acylamino-acid-releasing enzyme
            N-Acylpeptide hydrolase
            N-Formylmethionine (fMet) aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavege of an N-acetyl or N-formyl amino acid from the N-terminus
            of a polypeptide
SUBSTRATE   Acylaminoacyl-peptide
            H2O
            Glycyl-peptide
PRODUCT     N-Acetyl amino acid
            N-Formyl amino acid
            Peptide
            Glycyl amino acid
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Active at neutral pH. Several variants of this enzyme exist; the
            human erythrocyte enzyme is relatively specific for removal of
            N-acetylalanine from peptides. Displays dipeptidyl-peptidase
            activity on glycyl-peptides, perhaps as a result of mis-
            recognition of the glycyl residue as an uncharged N-acyl group.
            Inhibited by diisopropyl fluorophosphate. Formerly EC 3.4.14.3.
GENES       CEL: R11E3.8
            HSA: 327(APEH)
DISEASE     MIM: 102645  N-acylaminoacyl-peptide hydrolase
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.1
            ExPASy - ENZYME nomenclature database: 3.4.19.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.1
            BRENDA, the Enzyme Database: 3.4.19.1
///
ENTRY       EC 3.4.19.2
NAME        Peptidyl-glycinamidase
            Carboxyamidase
            Peptidyl carboxyamidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavage of C-terminal glycinamide from polypeptides
SUBSTRATE   Peptide
            H2O
PRODUCT     Glycine
            Peptide
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Inactivates vasopressin and oxytocin by splitting off glycinamide.
            Also cleaves ester substrates of trypsin and chymotrypsin.
            Although glycinamide is by far the preferred cleaving group, other
            aminoacylamides may also be released, e.g. phenylalaninamide. The
            toad skin enzyme is inhibited by diisopropyl fluorophosphate.
            Formerly EC 3.4.15.2.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.2
            ExPASy - ENZYME nomenclature database: 3.4.19.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.2
            BRENDA, the Enzyme Database: 3.4.19.2
///
ENTRY       EC 3.4.19.3
NAME        Pyroglutamyl-peptidase I
            5-Oxoprolyl-peptidase
            Pyrrolidone-carboxylate peptidase
            Pyroglutamyl aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Release of an N-terminal pyroglutamyl group from a polypeptide,
            provided the next residue is not proline
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Thiol-blocking reagent
COMMENT     Inhibited by thiol-blocking reagents.  Occurs in mammalian
            tissues, microorganisms and plants.  Formerly EC 3.4.11.8.
GENES       YPE: YPO2703(pcp)
            BSU: BG10873(pcp)
            BHA: BH3631(pcp)
            SAU: SA2482(pcp)
            SAV: SAV2675(pcp)
            SPY: SPy0506(pcp)
            SPN: SP0860
            SPR: spr0762(pcp) spr1871(pcp-truncation) spr1872(pcp-truncation)
            MTU: Rv0319(pcp)
            MTC: MT0334
            DRA: DR0490
            PHO: PH0596
            PAB: PAB1419
            SSO: SSO1465(pcp) SSO1607(pcp-like)
            HSA: 54858(FLJ20208)
MOTIF       PS: PS01333  [LI]-[ST]-x-E-R-[LIV]-A-x-N-x(2)-[DE]
            PS: PS01334  G-[LIV]-x-[GSA]-x-[LIV]-S-x-[STA]-A-G-x-[FY]-[LIV]-C-N
STRUCTURES  PDB: 1A2Z  1AUG  1IOF  1IOI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.3
            ExPASy - ENZYME nomenclature database: 3.4.19.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.3
            BRENDA, the Enzyme Database: 3.4.19.3
            SCOP (Structural Classification of Proteins): 3.4.19.3
///
ENTRY       EC 3.4.19.4
NAME        Deleted entry
            N-Acetylmethionylpeptide peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.4
            ExPASy - ENZYME nomenclature database: 3.4.19.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.4
///
ENTRY       EC 3.4.19.5
NAME        beta-Aspartyl-peptidase
            beta-Aspartyl dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavage of a beta-linked aspartic residue from the N-terminus of
            a polypeptide
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Peptide
COMMENT     Other isopeptide bonds, e.g. gamma-glutamyl and beta-alanyl, are
            not hydorlyzed. A mammalian, cytosolic enzyme. Formerly
            EC 3.4.13.10.
GENES       ECO: b4328(iadA)
            ECE: Z5927(iadA)
            ECS: ECs5286
            BHA: BH1129
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.5
            ExPASy - ENZYME nomenclature database: 3.4.19.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.5
            BRENDA, the Enzyme Database: 3.4.19.5
///
ENTRY       EC 3.4.19.6
NAME        Pyroglutamyl-peptidase II
            Thyroliberinase
            Pyroglutamyl aminopeptidase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa
            tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides
SUBSTRATE   PyroGlu-His-Xaa
            PyroGlu-His-Xaa-Gly
            H2O
            Thyrotropin releasing hormone
PRODUCT     Pyroglutamate
INHIBITOR   Metal chelator
COMMENT     Highly specific for thyrotropin releasing hormone (pyroglutamyl-
            histidyl-prolylamide).  Will not cleave the pyroglutamyl-histidyl
            bond of luteinizing hormone releasing hormone.  Found in serum and
            brain.  Inhibited by metal chelators.
GENES       HSA: 29953(TRHDE)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.6
            ExPASy - ENZYME nomenclature database: 3.4.19.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.6
            BRENDA, the Enzyme Database: 3.4.19.6
///
ENTRY       EC 3.4.19.7
NAME        N-Formylmethionyl-peptidase
            (fMet)-releasing enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Release of an N-terminal, formyl-methionyl residue from a
            polypeptide
SUBSTRATE   Peptide
            H2O
PRODUCT     Formyl-methionine
            Peptide
INHIBITOR   Heavy metal
EFFECTOR    Chloride
COMMENT     Highly specific for N-formylmethionyl peptides.  Will not cleave
            methionyl peptides or N-formyl derivatives of amino acids other
            than methionine.  Isolated from rat liver.  Inhibited by heavy
            metals and activated by Cl-.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.7
            ExPASy - ENZYME nomenclature database: 3.4.19.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.7
            BRENDA, the Enzyme Database: 3.4.19.7
///
ENTRY       EC 3.4.19.8
NAME        Pteroylpoly-gamma-glutamate carboxypeptidase
            Microsomal gamma-glutamyl carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Removal of a gamma-glutamyl residue from the unsubstituted
            C-terminus of pteroylpoly-gamma-glutamate
SUBSTRATE   Pteroylpoly-gamma-glutamate
            H2O
PRODUCT     Glutamate
            Folic acid
EFFECTOR    Metal
COMMENT     A high Mr, membrane-bound, brush-border exopeptidase.
            Sequentially removes gamma-glutamyl residues from pteroylpoly-
            gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and
            free glutamic acid. Requires the presence of a pteroyl N-terminus.
            Shows no thiol dependence, but is metal dependent.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.8
            ExPASy - ENZYME nomenclature database: 3.4.19.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.8
            BRENDA, the Enzyme Database: 3.4.19.8
///
ENTRY       EC 3.4.19.9
NAME        gamma-Glu-X carboxypeptidase
            Conjugase
            Folate conjugase
            Pteroyl-poly-gamma-glutamate hydrolase
            Carboxypeptidase G
            gamma-Glutamyl hydrolase
            Lysosomal gamma-glutamyl carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Cleavage of a gamma-glutamyl bond to release an unsubstituted
            C-terminal amino acid
SUBSTRATE   Peptide
            H2O
            Pteroylpoly-gamma-glutamate
PRODUCT     Amino acid
            Peptide
            Folic acid
COMMENT     A lysosomal, thiol-dependent carboxypeptidase that progressively
            removes gamma-glutamyl residues at acidic pH from pteroylpoly-
            gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and
            free glutamic acid. The presence of a free alpha-carboxyl group
            at each gamma-glutamyl linkage in a polyp-gamma-glutamate chain
            may account for reports that more than one gamma-glutamyl residue
            may be released at a time. Highly specific for gamma-glutamyl
            bond, but not for the C-terminal amino acid (leaving group).
            Action on gamma-glutamyl bonds is independent on an N-terminal
            pteroyl moiety.  Formerly EC 3.4.22.12.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       HSA: 8836(GGH)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.9
            ExPASy - ENZYME nomenclature database: 3.4.19.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.9
            BRENDA, the Enzyme Database: 3.4.19.9
///
ENTRY       EC 3.4.19.10
NAME        Transferred to EC 3.5.1.28
            Acylmuramoyl-alanine carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
COMMENT     Transferred entry. Now included in EC 3.5.1.28 - N-Acetylmuramoyl-
            L-alanine amidase.
            This enzyme from Bacillus megaterium and B. subtilis has
            a high affinity for the amide bonds formed between the amino
            sugar, acylmuramic acid and alanine in the bacterial cell wall.
            Cleavage of these bonds contributes to lysis of the cell wall.
            Activity is stimulated by divalent cations. Formerly EC 3.4.12.5
            and 3.4.17.7. The N-acylmuramoyl-|-alanine bond is also cleaved by
            beta-lytic metalloendopeptidase, EC 3.4.24.32.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.10
            ExPASy - ENZYME nomenclature database: 3.4.19.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.10
            BRENDA, the Enzyme Database: 3.4.19.10
///
ENTRY       EC 3.4.19.11
NAME        Gamma-D-Glutamyl-meso-diaminopimelate peptidase I
            Endopeptidase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Omega peptidases
REACTION    Hydrolysis of gamma-D-Glutamyl bonds to (L)meso-Diaminopimelic acid
            in L-Ala-gamma-D-Glu-|-(L)meso-Diaminopimelic acid-(L)-D-Ala. It is
            required that the omega-Amino group are unsubstituted.
COMMENT     Metallopeptidase from B.sphaericus, the substrates being components
            of the bacterial spore wall.
MOTIF       PS: PS00132  [PK]-x-[LIVMFY]-x-[LIVMFY]-x(4)-H-[STAG]-x-E-x-[LIVM]-
                         [STAG]-x(6)-[LIVMFYTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.19.11
            ExPASy - ENZYME nomenclature database: 3.4.19.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.19.11
            BRENDA, the Enzyme Database: 3.4.19.11
///
ENTRY       EC 3.4.21.1
NAME        Chymotrypsin
            Chymotrypsin A
            Chymotrypsin B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Tyr+, Trp+, Phe+, Leu+
SUBSTRATE   Peptide
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Tyr-, Trp-, Phe-, Leu-)
            Alcohol
INHIBITOR   Tos-Phe-CH2Cl
COMMENT     Chymotrypsin A is formed from cattle and pig chymotrypsinogen A,
            several iso-forms being produced according to the number of bonds
            hydrolysed in the precursor.  Formerly EC 3.4.4.5.  Chymotrypsin
            B, formerly EC 3.4.4.6, formed from chymotrypsinogen B, is
            homologous with chymotrypsin A.  Enzymes with specificity similar
            to that of chymotrypsins A and B have been isolated from many
            species.
GENES       MMU: 88559(Ctrb)
            HSA: 1504(CTRB1)
DISEASE     MIM: 118890  Chymotrypsinogen B1
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 8GCH  1AB9  1ACB  1AFQ  1CA0  1CBW  1CHO  1DLK  1EQ9  1EX3  
                 1GCD  1GCT  1GG6  1GGD  1GHA  1GHB  1GMC  1GMD  1GMH  1HJA  
                 1MTN  1VGC  2CHA  2GCH  2GCT  2GMT  2VGC  3GCH  3GCT  3VGC  
                 4CHA  4GCH  4VGC  5CHA  5GCH  6CHA  6GCH  7GCH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.1
            ExPASy - ENZYME nomenclature database: 3.4.21.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.1
            BRENDA, the Enzyme Database: 3.4.21.1
            SCOP (Structural Classification of Proteins): 3.4.21.1
///
ENTRY       EC 3.4.21.2
NAME        Chymotrypsin C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Leu+, Tyr+, Phe+, Met+, Trp+, Gln+, Asn+
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     Formed from pig chymotrypsinogen C, and from cattle subunit II of
            procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl
            than Tos-Phe-CH2Cl, in contrast to chymotrypsin.
GENES       HSA: 11330(CTRC)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.2
            ExPASy - ENZYME nomenclature database: 3.4.21.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.2
            BRENDA, the Enzyme Database: 3.4.21.2
///
ENTRY       EC 3.4.21.3
NAME        Metridin
            Metridium proteinase A
            Sea anemone protease A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Tyr+, Phe+, Leu+; little action on Trp+
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     Digestive enzyme from the sea anemone Metridium senile.
            A homologue of chymotrypsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.3
            ExPASy - ENZYME nomenclature database: 3.4.21.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.3
            BRENDA, the Enzyme Database: 3.4.21.3
///
ENTRY       EC 3.4.21.4
NAME        Trypsin
            Cocoonase
            Streptomyces griseus trypsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Arg+, Lys+
SUBSTRATE   Peptide
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Arg-, Lys-)
            Alcohol
INHIBITOR   Tos-Arg-CH2Cl
            Tos-Lys-CH2Cl
COMMENT     The single polypeptide chain cattle beta-trypsin is formed from
            trypsinogen by cheavage of one peptide bond.  Further peptide
            bond cleavages produce alpha and other iso-forms.  Isolated as
            multiple cationic and anionic trypsins from the pancreas of many
            vertebrates and from lower species including crayfish, insects
            (cocoonase) and microorganisms (Streptomyces griseus trypsin).
            Formerly EC 3.4.4.4.
GENES       DME: CG10882 CG12351(gammaTry) CG12385(thetaTry) CG12386(etaTry)
                 CG12387(zetaTry) CG12388 CG13430 CG14780(EG:80H7.3) CG18211
                 CG18444 CG18681 CG3795(EG:9D2.4) CG7754(iotaTry)
                 CG9564(Try29F)
            HSA: 5644(PRSS1) 5645(PRSS2) 5646(PRSS3) 5647(PRSS4)
DISEASE     MIM: 276000  Protease, serine, 1 (trypsin 1)
            MIM: 601564  Protease, serine, 2 (trypsin 2)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1C1R  1PPC  1C2E  1C2F  5PTP  3TGK  3TGJ  3TGI  3PTN  3PTB  
                 3BTW  3BTT  3BTQ  3BTM  1BRC  1BZX  3BTG  3BTF  3BTE  3BTD  
                 2TRM  2TLD  2TIO  2TBS  2STB  2STA  2PTN  2PTC  2BZA  2BTC  
                 1YYY  1XUK  1XUJ  1XUI  1XUH  1XUG  1XUF  1TRY  1TRN  1TRM  
                 1TPP  1TPO  1TPA  1TNL  1TNK  1TNJ  1TNI  1TNH  1TNG  1TLD  
                 1TIO  1TFX  1TAW  1TAB  1SMF  1SLX  1SLW  1SLV  1SLU  1SGT  
                 1SFI  1SBW  1QQU  1QL9  1QL8  1QL7  1QBO  1QBN  1QB9  1QB6  
                 1QB1  1QA0  1PPH  1PPE  1BTZ  1NTP  1MTW  1MTV  1MTU  1MTS  
                 1MCT  1MAY  1MAX  1LDT  1JRT  1JRS  1JIR  1J8A  1I99  1GDU  
                 1GDQ  1GDN  1GBT  1G9I  1G3E  1G3D  1G3C  1G3B  1FY8  1FY5  
                 1FY4  1FNI  1FN8  1FN6  1FMG  1F7Z  1F5R  1F2S  1F0U  1F0T  
                 1EZX  1EZU  1EZS  1EWU  1EPT  1EJM  1EJA  1DPO  1DF2  1D6R  
                 1D3O  1CU9  1CU8  1CU7  1CE5  1C9T  1C9P  1C5V  1A0J  1AKS  
                 1AMH  1AN1  1ANB  1ANC  1AND  1ANE  1AQ7  1AUJ  1AVW  1AVX  
                 1AZ8  1BJU  1BJV  1BRA  1BRB  1C1N  1BTP  1BTW  1BTX  1BTY  
                 3BTK  1C2H  1C5U  1C1O  1C1P  1C1Q  1C2I  1C1S  1C1T  1C2D  
                 1C2J  3BTH  1C2G  1C2K  1C2L  1C2M  1C5P  1C5Q  1C5R  1C5S  
                 1C5T  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.4
            ExPASy - ENZYME nomenclature database: 3.4.21.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.4
            BRENDA, the Enzyme Database: 3.4.21.4
            SCOP (Structural Classification of Proteins): 3.4.21.4
///
ENTRY       EC 3.4.21.5
NAME        Thrombin
            Fibrinogenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin
            and release fibrinopeptides A and B
SUBSTRATE   Peptide
            Fibrinogen
            Amide
            Ester
            H2O
PRODUCT     Amino acid(Arg-)
            Fibrin
            Alcohol
            Fibrinopeptide A
            Fibrinopeptide B
INHIBITOR   Benzamidine
            D-Phe-Pro-Arg-CH2Cl
            Nalpha-(2-naphthyl-sulfonyl-glycyl)-D-para-amidinopheyl-
            $alanylpiperadine
            (2R,4R)-4-Methyl-1[Nalpha-[(3-methyl-1,2,3,4-tetrahydro-
            $8-quinolinyl)sulfonyl]-L-arginyl)]-2-
            $piperadinecarboxylic acid
COMMENT     Formed from prothrombin.  More selective than trypsin and plasmin.
            A homologue of chymotrypsin.  Formerly EC 3.4.4.13.
            Inhibitors: J.Biol.Chem.266,20085-20093(1991)
GENES       MMU: 88380
            HSA: 2147
DISEASE     MIM: 176930  Coagulation factor II (thrombin)
MOTIF       PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS50070  Kringle domain profile
STRUCTURES  PDB: 1HAI  1AIX  1HAO  8KME  1AVG  1AWF  1AWH  1AY6  1B5G  1B7X  
                 1BA8  1BB0  1BBR  1BCU  1BHX  1BMM  1BMN  1BTH  1C1U  1C1V  
                 1C1W  1C4U  1C4V  1C4Y  1C5L  1C5N  1C5O  1CA8  1D3D  1D3P  
                 1D3Q  1D3T  1D4P  1D6W  1D9I  1DE7  1DIT  1DOJ  1DWB  1DWC  
                 1DWD  1DWE  1DX5  1E0F  1EOJ  1EOL  1ETR  1ETS  1ETT  1FPC  
                 1FPH  1G37  1H8D  1H8I  1HAG  1HAH  7KME  1AI8  1HAP  1HBT  
                 1HDT  1HGT  1HRT  1HUT  1HXE  1HXF  1ID5  1IHS  1IHT  1LHC  
                 1LHD  1LHE  1LHF  1LHG  1MKW  1MKX  1NRN  1NRO  1NRP  1NRQ  
                 1NRR  1NRS  1PPB  1QBV  1QHR  1QJ1  1QJ6  1QJ7  1TBQ  1TBR  
                 1TBZ  1THP  1THR  1THS  1TMB  1TMT  1TMU  1TOC  1TOM  1UCY  
                 1UMA  1UVS  1UVT  1UVU  1VIT  1YCP  2HGT  2HPP  2HPQ  2SPT  
                 2THF  3HAT  3HTC  4HTC  4THN  5GDS  1AD8  1ABJ  1AHT  1AFE  
                 1AE8  1A3B  1A2C  1A0H  1ABI  1A61  1A5G  1A4W  1A46  1A3E  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.5
            ExPASy - ENZYME nomenclature database: 3.4.21.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.5
            BRENDA, the Enzyme Database: 3.4.21.5
            SCOP (Structural Classification of Proteins): 3.4.21.5
///
ENTRY       EC 3.4.21.6
NAME        Coagulation Factor Xa
            Thrombokinase
            Prothrombase
            Prothrombinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in
            prothrombin to form thrombin
SUBSTRATE   Peptide
            Prothrombin
            Amide
            Ester
            H2O
PRODUCT     Amino acid
            Thrombin
            Alcohol
COMMENT     Formed from the proenzyme Factor X by limited proteolysis. A
            homologue of chymotrypsin. Scutelarin (EC 3.4.21.60) has similar
            specificity.
GENES       HSA: 2159(F10)
DISEASE     MIM: 227600  Coagulation factor X
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 1IOD  1KIG  1WHE  1WHF  1C5M  1EZQ  1FJS  1FAX  1F0S  1F0R  
                 1XKB  1XKA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.6
            ExPASy - ENZYME nomenclature database: 3.4.21.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.6
            BRENDA, the Enzyme Database: 3.4.21.6
            SCOP (Structural Classification of Proteins): 3.4.21.6
///
ENTRY       EC 3.4.21.7
NAME        Plasmin
            Fibrinase
            Fibrinolysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Lys+ > Arg+; higher selectivity than
            trypsin.  Converts fibrin into soluble products
SUBSTRATE   Peptide(Lys-, Arg-)
            Peptide
            Fibrin
            Amide
            Ester
            H2O
PRODUCT     Amino acid
            Alcohol
COMMENT     Formed from plasminogen by proteolysis which results in multiple
            forms of the active plasmin. A homologue of chymotrypsin.
            Formerly EC 3.4.4.14.
GENES       MMU: 97620(Plg)
            HSA: 5340(PLG)
DISEASE     MIM: 173350  Plasminogen
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS50070  Kringle domain profile
STRUCTURES  PDB: 1HPJ  1HPK  1I5K  1KRN  5HPG  1PMK  1B2I  1BML  1BUI  1CEA  
                 1CEB  1DDJ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.7
            ExPASy - ENZYME nomenclature database: 3.4.21.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.7
            BRENDA, the Enzyme Database: 3.4.21.7
            SCOP (Structural Classification of Proteins): 3.4.21.7
///
ENTRY       EC 3.4.21.8
NAME        Transferred to EC 3.4.21.34 and 3.4.21.35
            Plasma kallikrein
            Tissue kallikrein
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.21.34 - Plasma kallikrein and
            EC 3.4.21.35 - Tissue kallikrein.
STRUCTURES  PDB: 2KAI  2PKA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.8
            ExPASy - ENZYME nomenclature database: 3.4.21.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.8
            SCOP (Structural Classification of Proteins): 3.4.21.8
///
ENTRY       EC 3.4.21.9
NAME        Enteropeptidase
            Enterokinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Activation of trypsinogen by selective cleavage of Lys6-|-Ile bond
SUBSTRATE   Trypsinogen
            H2O
PRODUCT     Trypsin
COMMENT     Is not inhibited by protein inhibitors of trypsin.  A homologue of
            chymotrypsin. Formerly EC 3.4.4.8.
GENES       HSA: 5651(PRSS7)
DISEASE     MIM: 226200  Protease, serine, 7 (enterokinase)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS00740  G-x-[LIVMFY](2)-x(3)-[STA]-x(10,11)-[LV]-x(4)-[LIVMF]-
                         x(6,7)-C-[LIVM]-x-F-x-[LIVMFY]-x(3)-[GSC]
            PS: PS01180  CUB domain profile
            PS: PS01209  C-[VILMA]-x(5)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADE]-
                         [DEH]-[DE]-x(1,5)-C
            PS: PS50060  MAM domain profile
            PS: PS50068  LDL-receptor class A (LDLRA) domain profile
STRUCTURES  PDB: 1EKB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.9
            ExPASy - ENZYME nomenclature database: 3.4.21.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.9
            BRENDA, the Enzyme Database: 3.4.21.9
            SCOP (Structural Classification of Proteins): 3.4.21.9
///
ENTRY       EC 3.4.21.10
NAME        Acrosin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Arg+, Lys+
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Amino acid
INHIBITOR   Tripsin inhibitor
COMMENT     Occurs in spermatozoa; formed from proacrosin by limited
            proteolysis. Inhibited by naturally occurring tripsin inhibitors.
GENES       MMU: 87884(Acr)
            HSA: 49(ACR)
DISEASE     MIM: 102480  Acrosin
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.10
            ExPASy - ENZYME nomenclature database: 3.4.21.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.10
            BRENDA, the Enzyme Database: 3.4.21.10
///
ENTRY       EC 3.4.21.11
NAME        Transferred to EC 3.4.21.36 and 3.4.21.37
            Pancreatic elastase
            Leukocyte elastase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.21.36 - Pancreatic elastase and
            EC 3.4.21.37 - Leukocyte elastase.
STRUCTURES  PDB: 1EST  1HAX  1HAY  1HAZ  1HB0  1QIX  2EST  3EST  4EST  5EST  
                 6EST  7EST  8EST  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.11
            ExPASy - ENZYME nomenclature database: 3.4.21.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.11
            SCOP (Structural Classification of Proteins): 3.4.21.11
///
ENTRY       EC 3.4.21.12
NAME        alpha-Lytic endopeptidase
            Myxobacter alpha-lytic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Ala+, Val+ in bacterial cell walls, elastin
            and other proteins
SUBSTRATE   Protein alanine
            Peptide
            H2O
PRODUCT     Oligopeptide
            Peptide
COMMENT     From the myxobacterium Lysobacter enzymogenes.  A homologue of
            chymotrypsin.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1BOQ  1GBA  1GBB  1GBC  1GBD  1GBE  1GBF  1GBH  1GBI  1GBJ  
                 1GBK  1GBL  1GBM  1P01  1P02  1P03  1P04  1P05  1P06  1P09  
                 1P10  1P11  1P12  1QQ4  1QRW  1QRX  1TAL  2ALP  2LPR  2ULL  
                 3LPR  5LPR  6LPR  7LPR  8LPR  9LPR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.12
            ExPASy - ENZYME nomenclature database: 3.4.21.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.12
            BRENDA, the Enzyme Database: 3.4.21.12
            SCOP (Structural Classification of Proteins): 3.4.21.12
///
ENTRY       EC 3.4.21.13
NAME        Transferred to EC 3.4.16.1
            Serine-type carboxypeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.16.1 - Serine-type carboxypeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.13
            ExPASy - ENZYME nomenclature database: 3.4.21.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.13
///
ENTRY       EC 3.4.21.14
NAME        Deleted entry
            Microbial serine proteinases
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry. See EC 3.4.21.62 - Subtilisin;
            EC 3.4.21.63 - Oryzin; EC 3.4.21.64 - Endopeptidase K;
            EC 3.4.21.65 - Thermomycolin; and EC 3.4.21.67 - Endopeptidase So.
STRUCTURES  PDB: 2PRK  2ST1  2SNI  2SIC  2SBT  1S01  1S02  1SBT  3TEC  2TEC  
                 1MEE  1YJC  1YJB  1YJA  1TEC  1ST2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.14
            ExPASy - ENZYME nomenclature database: 3.4.21.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.14
            SCOP (Structural Classification of Proteins): 3.4.21.14
///
ENTRY       EC 3.4.21.15
NAME        Transferred to EC 3.4.21.63
            Oryzin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.21.63 - Oryzin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.15
            ExPASy - ENZYME nomenclature database: 3.4.21.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.15
///
ENTRY       EC 3.4.21.16
NAME        Deleted entry
            Alternaria serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.16
            ExPASy - ENZYME nomenclature database: 3.4.21.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.16
///
ENTRY       EC 3.4.21.17
NAME        Deleted entry
            Arthrobacter serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.17
            ExPASy - ENZYME nomenclature database: 3.4.21.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.17
///
ENTRY       EC 3.4.21.18
NAME        Deleted entry
            Tenebrio alpha-proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.18
            ExPASy - ENZYME nomenclature database: 3.4.21.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.18
///
ENTRY       EC 3.4.21.19
NAME        Glutamyl endopeptidase
            V8 Proteinase
            Endoproteinase Glu-C
            Staphylococcal serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Glu+, Asp+
SUBSTRATE   Protein glutamate
            Protein aspartate
            Peptide
            H2O
PRODUCT     Oligopeptide
            Peptide
COMMENT     From Staphylococcus aureus strain V8.  In appropriate buffer the
            specificity is restricted to Glu+.
GENES       MLO: mll3306
            SAU: SA0901(sspA)
            SAV: SAV1035
MOTIF       PS: PS00672  [ST]-G-[LIVMFYW](3)-[GN]-x(2)-T-[LIVM]-x-T-x(2)-H
            PS: PS00673  T-x(2)-[GC]-[NQ]-S-G-S-x-[LIVM]-[FY]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.19
            ExPASy - ENZYME nomenclature database: 3.4.21.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.19
            BRENDA, the Enzyme Database: 3.4.21.19
///
ENTRY       EC 3.4.21.20
NAME        Cathepsin G
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Tyr+, Trp+, Phe+, Leu+
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Oligopeptide
            Peptide
COMMENT     From azurophil granules of polymorphonuclear leukocytes. A
            homologue of chymotrypsin.
GENES       MMU: 88563(Ctsg)
            HSA: 1511(CTSG)
DISEASE     MIM: 116830  Cathepsin G
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1AU8  1CGH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.20
            ExPASy - ENZYME nomenclature database: 3.4.21.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.20
            BRENDA, the Enzyme Database: 3.4.21.20
            SCOP (Structural Classification of Proteins): 3.4.21.20
///
ENTRY       EC 3.4.21.21
NAME        Coagulation Factor VIIa
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Ile bond in Factor X to form Factor Xa
SUBSTRATE   Coagulation Factor X
            H2O
PRODUCT     Coagulation Factor Xa
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Formed from the precursor Factor VII.  The cattle enzyme is more
            readily inhibited by diisopropyl fluorophosphate than the human.
GENES       HSA: 2155
DISEASE     MIM: 227500  Coagulation factor VII
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 1FAK  1DVA  1QFK  1BF9  1CVW  1DAN  1JBU  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.21
            ExPASy - ENZYME nomenclature database: 3.4.21.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.21
            BRENDA, the Enzyme Database: 3.4.21.21
            SCOP (Structural Classification of Proteins): 3.4.21.21
///
ENTRY       EC 3.4.21.22
NAME        Coagulation Factor IXa
            Activated Christmas Factor
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Ile bond in Factor X to form Factor Xa
SUBSTRATE   Coagulation Factor X
            H2O
PRODUCT     Coagulation Factor Xa
COMMENT     A chymotrypsin homologue, and one of the gamma-carboxyglutamic
            acid-containing blood coagulation factors.  The proenzyme Factor
            IX is activated by Factor XIa.
GENES       MMU: 88384
            HSA: 2158
DISEASE     MIM: 306900  Coagulation factor IX (plasma thromboplastic
                         component)
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 1CFI  1MGX  1PFX  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.22
            ExPASy - ENZYME nomenclature database: 3.4.21.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.22
            BRENDA, the Enzyme Database: 3.4.21.22
            SCOP (Structural Classification of Proteins): 3.4.21.22
///
ENTRY       EC 3.4.21.23
NAME        Deleted entry
            Vipera russelli proteinase
            Coagulant protein of Russell's viper venom
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.23
            ExPASy - ENZYME nomenclature database: 3.4.21.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.23
///
ENTRY       EC 3.4.21.24
NAME        Deleted entry
            Red cell neutral endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.24
            ExPASy - ENZYME nomenclature database: 3.4.21.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.24
///
ENTRY       EC 3.4.21.25
NAME        Cucumisin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     From the sarcocarp of the musk melon (Cucumis melo). A homologue
            of subtilisin. Other endopeptidases from plants, which are less
            well characterized but presumably of serine-type, include
            euphorbain from Euphorbia cerifera (formerly EC 3.4.21.56),
            solanain from horse-nettle Solanum elaegnifolium (formerly
            EC 3.4.99.21), hurain from Hura crepitans (formerly EC 3.4.99.9)
            and tavernamontanain from Tabernamontana grandiflora
            (formerly EC 3.4.99.23).
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.25
            ExPASy - ENZYME nomenclature database: 3.4.21.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.25
            BRENDA, the Enzyme Database: 3.4.21.25
///
ENTRY       EC 3.4.21.26
NAME        Prolyl oligopeptidase
            Post-proline cleaving enzyme
            Proline-specific endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of Pro+ >> Ala+ in oligopeptides
SUBSTRATE   Oligopeptide
            Peptide
            H2O
            Oxytocin
            Vasopressin
PRODUCT     Oligopeptide
            Peptide
EFFECTOR    Thiol compound
COMMENT     Found in vertebrates, plants and Flavobacterium.  Generally
            cytosolic, commonly activated by thiol compounds.  Not homologous
            with chymotrypsin or subtilisin.
GENES       NMA: NMA0579
            MLO: mll1209
            DRA: DR2503
            PHO: PH1262
            PAB: PAB0762
            STO: ST0002
            DME: CG2528 CG5355
            HSA: 5550(PREP)
DISEASE     MIM: 600400  Prolyl endopeptidase
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
STRUCTURES  PDB: 1E5T  1E8M  1E8N  1QFM  1QFS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.26
            ExPASy - ENZYME nomenclature database: 3.4.21.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.26
            BRENDA, the Enzyme Database: 3.4.21.26
            SCOP (Structural Classification of Proteins): 3.4.21.26
///
ENTRY       EC 3.4.21.27
NAME        Coagulation Factor XIa
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in Factor IX to
            form Factor IXa
SUBSTRATE   Coagulation Factor IX
            H2O
PRODUCT     Coagulation Factor IXa
COMMENT     A homologue of chymotrypsin, and one of the gamma-carboxyglutamic
            acid-containing blood coagulation factors.  The proenzyme
            Factor XI is activated by Factor XIIa.
GENES       HSA: 2160(F11)
DISEASE     MIM: 264900  Coagulation factor XI (plasma thromboplastin
                         antecedent)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS00495  C-x(3)-[LIVMFY]-x(5)-[LIVMFY]-x(3)-[DENQ]-[LIVMFY]-
                         x(10)-C-x(3)-C-T-x(4)-C-x-[LIVMFY]-F-x-[FY]-x(13,14)-C-
                         x-[LIVMFY]-[RK]-x-[ST]-x(14,15)-S-G-x-[ST]-[LIVMFY]-
                         x(2)-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.27
            ExPASy - ENZYME nomenclature database: 3.4.21.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.27
            BRENDA, the Enzyme Database: 3.4.21.27
///
ENTRY       EC 3.4.21.28
NAME        Transferred to EC 3.4.21.74
            Venombin A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.21.74 - Venombin A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.28
            ExPASy - ENZYME nomenclature database: 3.4.21.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.28
///
ENTRY       EC 3.4.21.29
NAME        Transferred to EC 3.4.21.74
            Venombin A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.21.74 - Venombin A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.29
            ExPASy - ENZYME nomenclature database: 3.4.21.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.29
///
ENTRY       EC 3.4.21.30
NAME        Transferred to EC 3.4.21.74
            Venombin A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.21.74 - Venombin A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.30
            ExPASy - ENZYME nomenclature database: 3.4.21.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.30
///
ENTRY       EC 3.4.21.31
NAME        Transferred to EC 3.4.21.68 and 3.4.21.73
            t-Plasminogen activator
            u-Plasminogen activator
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.21.68 - t-Plasminogen activator and
            EC 3.4.21.73 - u-Plasminogen activator.
STRUCTURES  PDB: 1TPK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.31
            ExPASy - ENZYME nomenclature database: 3.4.21.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.31
            SCOP (Structural Classification of Proteins): 3.4.21.31
///
ENTRY       EC 3.4.21.32
NAME        Barchyurin
            Uca pugilator collagenolytic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, with broad specificity for peptide bonds.
            Native collagen is cleaved about 75% of the length of the molecule
            from the N-terminus.  Low activity on small molecule substrates of
            both trypsin and chymotrypsin.
SUBSTRATE   Collagen
            H2O
            Protein
            Peptide
PRODUCT     Protein
            Peptide
INHIBITOR   Tos-Lys-CH2Cl
COMMENT     From hepatopancreas of the fiddler crab, Uca pugilator. A
            homologue of chymotrypsin.  Other serine endopeptidases that
            degrade collagen, but are not listed separately here, include a
            second endopeptidases from Uca pugilator, digestive enzymes
            from other decapod crustacea, and an enzyme from the fungus
            Entomophthora (formerly EC 3.4.21.33).
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1AZZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.32
            ExPASy - ENZYME nomenclature database: 3.4.21.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.32
            BRENDA, the Enzyme Database: 3.4.21.32
            SCOP (Structural Classification of Proteins): 3.4.21.32
///
ENTRY       EC 3.4.21.33
NAME        Deleted entry
            Entomophthora collagenolytic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.33
            ExPASy - ENZYME nomenclature database: 3.4.21.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.33
///
ENTRY       EC 3.4.21.34
NAME        Plasma kallikrein
            Serum kallikrein
            Kininogenin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavege of some Arg+ and Lys+ bonds, including Lys-|-Arg
            and Arg-|-Ser in (human) kininogen to release bradykinin
SUBSTRATE   Kininogen
            Polyarginine
            H2O
PRODUCT     Bradykinin
COMMENT     Formed from plasma prokallikrein (Fletcher factor) by Factor XIIa.
            Activates coagulation Factors XII, VII and plasminogen. Selective
            for Arg > Lys in P1, in small molecule substrates.  A homologue of
            chymotrypsin.  Formerly EC 3.4.4.21 and included in 3.4.21.8.
GENES       HSA: 3818(KLKB1)
DISEASE     MIM: 229000  Kallikrein B plasma 1 (Fletcher factor)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS00495  C-x(3)-[LIVMFY]-x(5)-[LIVMFY]-x(3)-[DENQ]-[LIVMFY]-
                         x(10)-C-x(3)-C-T-x(4)-C-x-[LIVMFY]-F-x-[FY]-x(13,14)-C-
                         x-[LIVMFY]-[RK]-x-[ST]-x(14,15)-S-G-x-[ST]-[LIVMFY]-
                         x(2)-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.34
            ExPASy - ENZYME nomenclature database: 3.4.21.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.34
            BRENDA, the Enzyme Database: 3.4.21.34
///
ENTRY       EC 3.4.21.35
NAME        Tissue kallikrein
            Glandular kallikrein
            Pancreatic kallikrein
            Submandibular kallikrein
            Submaxillary kallikrein
            Kidney kallikrein
            Urinary kallikrein
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavege of Arg+ bonds in small molecule substrates.
            Highly selective action to release kallidin (lysyl-bradykinin)
            from kininogen involves hydrolysis of Met+ or Leu+. The rat enzyme
            is unusual in liberating bradykinin directly from autologous
            kininogens by cleavage at two Arg+ bonds
SUBSTRATE   Kininogen
            H2O
PRODUCT     Lysyl-bradykinin
            Kallidin
            Bradykinin
COMMENT     Formed from tissue prokallikrein by activation with trypsin.  A
            homologue of chymotrypsin.  Formerly EC 3.4.4.21 and included in
            3.4.21.8.  A large number of tissue kallikrein-related sequences
            have been reported for rats and mice, though fewer
            seem to exist in other mammals.  The few that have been isolated
            and tested on substrates include mouse gamma-renin (EC 3.4.21.54),
            submandibular proteinase A (formerly EC 3.4.21.40, 142, 430),
            epidermal growth-factor-binding protein, nerve growth factor
            gamma-subunit, rat tonin, submaxillary proteinases A and B,
            T-kininogenase, kallikreins k7 and k8 and human
            prostate-specific antigen (gamma-seminoprotein).
GENES       MMU: 95293(Egfbp3)
            HSA: 3816(KLK1) 3817(KLK2)
DISEASE     MIM: 147910  Kallikrein, renal/pancreas/salivary
            MIM: 147960  Kallikrein-2, prostatic
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1AO5  1HIA  1SGF  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.35
            ExPASy - ENZYME nomenclature database: 3.4.21.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.35
            BRENDA, the Enzyme Database: 3.4.21.35
            SCOP (Structural Classification of Proteins): 3.4.21.35
///
ENTRY       EC 3.4.21.36
NAME        Pancreatic elastase
            Pancreatopeptidase E
            Pancreatic elastase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including elastin.  Preferential cleavage:
            Ala+
SUBSTRATE   Protein
            Peptide
            Elastin
            H2O
PRODUCT     Oligopeptide
            Protein
            Peptide
COMMENT     Formed by activation of proelastase from mammalian pancreas by
            trypsin.  A homologue of chymotrypsin.  Formerly included in
            EC 3.4.21.11.
GENES       MMU: 95314(Ela1)
DISEASE     MIM: 130120  Elastase-1
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1B0E  1BMA  1ELB  1C1M  1E34  1E35  1E36  1E37  1E38  1EAI  
                 1EAS  1EAT  1EAU  1ELA  1ESB  1ELC  1ELD  1ELE  1ELF  1ELG  
                 1ELT  1ESA  1FZZ  1LVY  1BTU  9EST  1FLE  1HV7  1INC  1JIM  
                 1QR3  1NES  1QGF  1QNJ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.36
            ExPASy - ENZYME nomenclature database: 3.4.21.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.36
            BRENDA, the Enzyme Database: 3.4.21.36
            SCOP (Structural Classification of Proteins): 3.4.21.36
///
ENTRY       EC 3.4.21.37
NAME        Leukocyte elastase
            Lysosomal elastase
            Neutrophil elastase
            Polymorphonuclear leukocyte elastase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including elastin.  Preferential cleavage:
            Val+ > Ala+
SUBSTRATE   Protein
            Peptide
            H2O
            Elastin
PRODUCT     Oligopeptide
            Protein
            Peptide
COMMENT     Differs from pancreatic elastase in specificity on synthetic
            substrates and in inhibitor sensitivity.  A homologue of
            chymotrypsin.  Formerly included in EC 3.4.21.11.
GENES       HSA: 1991(ELA2)
DISEASE     MIM: 130130  Elastase-2, neutrophil
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1PPG  1HNE  1PPF  1B0F  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.37
            ExPASy - ENZYME nomenclature database: 3.4.21.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.37
            BRENDA, the Enzyme Database: 3.4.21.37
            SCOP (Structural Classification of Proteins): 3.4.21.37
///
ENTRY       EC 3.4.21.38
NAME        Coagulation Factor XIIa
            Hageman Factor (activated)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Ile bonds in Factor VII to form Factor
            VIIa and Factor XI to form Factor XIa
SUBSTRATE   Coagulation Factor VII
            Coagulation Factor XI
            Coagulation Factor XII
            Plasminogen
            Prokallikrein
            H2O
PRODUCT     Coagulation Factor VIIa
            Coagulation Factor XIa
            Coagulation Factor XIIa
            Plasmin
            Kallikrein
COMMENT     Also activates plasminogen and plasma prokallikrein.  Formed from
            the proenzyme, Factor XII, by plasma kallikrein or Factor XIIa.  A
            homologue of chymotrypsin.
GENES       HSA: 2161(F12)
DISEASE     MIM: 234000  Coagulation factor XII (Hageman factor)
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00023  C-x(2)-P-F-x-[FYWI]-x(7)-C-x(8,10)-W-C-x(4)-[DNSR]-
                         [FYW]-x(3,5)-[FYW]-x-[FYWI]-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01253  C-x(6,8)-[LFY]-x(5)-[FYW]-x-[RK]-x(8,10)-C-x-C-x(6,9)-C
            PS: PS50070  Kringle domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.38
            ExPASy - ENZYME nomenclature database: 3.4.21.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.38
            BRENDA, the Enzyme Database: 3.4.21.38
///
ENTRY       EC 3.4.21.39
NAME        Chymase
            Mast cell protease I
            Skeletal muscle protease
            Skin chymotryptic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Phe+ > Tyr+ > Trp+ > Leu+
SUBSTRATE   Peptide
            H2O
PRODUCT     Oligopeptide
            Peptide
COMMENT     In mast cell granules.  A homologue of chymotrypsin.
GENES       HSA: 1215(CMA1)
DISEASE     MIM: 118938  Chymase-1, mast cell
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1PJP  1KLT  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.39
            ExPASy - ENZYME nomenclature database: 3.4.21.39
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.39
            BRENDA, the Enzyme Database: 3.4.21.39
            SCOP (Structural Classification of Proteins): 3.4.21.39
///
ENTRY       EC 3.4.21.40
NAME        Deleted entry
            Submandibular proteinase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.40
            ExPASy - ENZYME nomenclature database: 3.4.21.40
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.40
///
ENTRY       EC 3.4.21.41
NAME        Complement subcomponent C1r-
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Lys(or Arg)+Ile bond in complement
            subcomponent C1s to form C1s- (EC 3.4.21.42)
SUBSTRATE   Complement subcomponent C1s
            H2O
PRODUCT     Complement subcomponent C1s-
COMMENT     Activated from proenzyme C1r in plasma during activation of the
            complement system by the 'classical' route.  A homologue of
            chymotrypsin.
GENES       HSA: 715(C1R)
DISEASE     MIM: 216950  Complement component-1, r subcomponent
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01180  CUB domain profile
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 1APQ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.41
            ExPASy - ENZYME nomenclature database: 3.4.21.41
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.41
            BRENDA, the Enzyme Database: 3.4.21.41
            SCOP (Structural Classification of Proteins): 3.4.21.41
///
ENTRY       EC 3.4.21.42
NAME        Complement subcomponent C1s-
            C1 esterase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of Arg-|-Ala bond in complement component C4 to form C4a
            and C4b, and Lys(or Arg)+Lys bond in complement component C2 to
            form C2a and C2b: the 'classical' pathway C3 convertase
SUBSTRATE   Complement component C4
            Complement component C2
            H2O
PRODUCT     Complement component C4a
            Complement component C4b
            Complement component C2a
            Complement component C2b
COMMENT     Activated from proenzyme C1s in plasma by complement
            subcomponent C1r-
GENES       HSA: 716(C1S)
DISEASE     MIM: 120580  Complement component-1, s subcomponent
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01180  CUB domain profile
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 1ELV  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.42
            ExPASy - ENZYME nomenclature database: 3.4.21.42
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.42
            BRENDA, the Enzyme Database: 3.4.21.42
///
ENTRY       EC 3.4.21.43
NAME        Classical-complement pathway C3/C5 convertase
            Complement C2
            C3 convertase
            C5 convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Ser bond in complement component C3
            alpha-chain to form C3a and C3b, and Arg+ bond in complement
            component C5 alpha-chain to form C5a and C5b
SUBSTRATE   H2O
            Peptide
PRODUCT     Peptide
COMMENT     A complex of complement fragments C4b, C2a and C2b.  C2a contains
            the active site, C2b the site for C4b binding.  C2a and C2b are
            formed by cleavage of proenzyme C2 by complement subcomponent C1s.
            Cleavage of C5 requires complement fragment C3b which binds C5 and
            renders it susceptible to cleavage by the C4b, 2a complex.
            INcludes former EC 3.4.21.44.
GENES       HSA: 717 718
DISEASE     MIM: 217000  Complement component-2
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.43
            ExPASy - ENZYME nomenclature database: 3.4.21.43
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.43
            BRENDA, the Enzyme Database: 3.4.21.43
///
ENTRY       EC 3.4.21.44
NAME        Transferred to EC 3.4.21.43
            Classical-complement-pathway C3/C5 convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Transferred entry.
            Now included with EC 3.4.21.43 -
            Classical-complement-pathway C3/C5 convertase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.44
            ExPASy - ENZYME nomenclature database: 3.4.21.44
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.44
///
ENTRY       EC 3.4.21.45
NAME        Complement Factor I
            Complement component C3b inactivator
            C3b inactivator
            C3b/C4b inactivator
            C3bINA
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Inactivates complement subcomponents C3b, iC3b and C4b by
            proteolytic cleavage
SUBSTRATE   Complement component C3b
            Complement component iC3b
            Complement component C4b
            H2O
COFACTOR    Factor H
            Complement receptor CR1
            C4b-binding protein
COMMENT     Cleavage of complement subcomponent C3b requires its binding to
            cofactor Factor H or complement receptor CR1; cleavage of
            iC3b requires complement receptor CR1; cleavage of C4b requires
            C4b-binding protein.
GENES       HSA: 3426
DISEASE     MIM: 217030  I factor (complement component I)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01209  C-[VILMA]-x(5)-C-[DNH]-x(3)-[DENQHT]-C-x(3,4)-[STADE]-
                         [DEH]-[DE]-x(1,5)-C
            PS: PS50068  LDL-receptor class A (LDLRA) domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.45
            ExPASy - ENZYME nomenclature database: 3.4.21.45
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.45
            BRENDA, the Enzyme Database: 3.4.21.45
///
ENTRY       EC 3.4.21.46
NAME        Complement Factor D
            C3 proactivator convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Lys bond in complement Factor B when in
            complex with complement subcomponent C3b or with cobra venom
            factor
SUBSTRATE   Complement factor B
            Complement component C3b
            Cobra venom factor
            H2O
PRODUCT     C3 convertase
COMMENT     A component of the alternative pathway of complement activation.
            This reaction is analogous to the activation of complement
            component C2 by complement subsomponent C1s-.
GENES       HSA: 1675
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1HFD  1FDP  1DSU  1DST  1DIC  1DFP  1BIO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.46
            ExPASy - ENZYME nomenclature database: 3.4.21.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.46
            BRENDA, the Enzyme Database: 3.4.21.46
            SCOP (Structural Classification of Proteins): 3.4.21.46
///
ENTRY       EC 3.4.21.47
NAME        Alternative-complement pathway C3/C5 convertase
            Complement factor B
            Complement component C3/C5 convertase (alternative)
            Properdin factor B
            C3 proactivator
            C3 convertase
            C5 convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain
            to yield C3a and C3b, and Arg+ bond in complement component C5
            alpha-chain to yield C5a and C5b
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A bimolecular complex of complement fragment Bb with either C3b or
            cobra venom factor; Bb contains the active site. Bb is formed by
            cleavage of proenzyme Factor B by Factor D.  Cleavage of
            complement component C5 requires additional C3b which binds C5 and
            renders it susceptible to cleavage by C3b,Bb complex.  C3b,Bb is
            stabilized in plasma by Factor P.
GENES       HSA: 629
DISEASE     MIM: 138470  Properdin factor B
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.47
            ExPASy - ENZYME nomenclature database: 3.4.21.47
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.47
            BRENDA, the Enzyme Database: 3.4.21.47
///
ENTRY       EC 3.4.21.48
NAME        Cerevisin
            Yeast proteinase B
            Proteinase yscB
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity, and of
            Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyse peptide amides
SUBSTRATE   Bz-Arg-OEt
            Ac-Tyr-OEt
            H2O
PRODUCT     Arg-OEt
            Tyr-OEt
INHIBITOR   Diisopropyl fluorophosphate
            p-Chloromercuribenzoate
            Hg
COMMENT     From Saccharomyces cerevisiae (baker's yeast, brewer's yeast).
            Homologue of subtilisin, but contains a Cys residue near the
            active site His, and is inhibited by mercurials.  Proteinase ycaB
            is a similar enzyme from the yeast Candida albicans.
GENES       AAE: aq_1950(aprV)
            SCE: YEL060C(PRB1)
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.48
            ExPASy - ENZYME nomenclature database: 3.4.21.48
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.48
            BRENDA, the Enzyme Database: 3.4.21.48
///
ENTRY       EC 3.4.21.49
NAME        Hypodermin C
            Hypoderma collagenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins including native collagen at +Ala bond
            leaving an N-terminal (75%) and a C-terminal (25%) fragment
SUBSTRATE   Collagen
PRODUCT     Peptide
COMMENT     From the larva of a warble fly Hypoderma lineatum.  Little action
            on small molecule substrates of trypsin, chymotrypsin, elastase or
            microbial collagenases.  A homologue of chymotrypsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.49
            ExPASy - ENZYME nomenclature database: 3.4.21.49
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.49
            BRENDA, the Enzyme Database: 3.4.21.49
///
ENTRY       EC 3.4.21.50
NAME        Lysyl endopeptidase
            Achromobacter proteinase I
            Endoproteinase Lys-C
            Ps-1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Lys+, including -Lys-|-Pro-
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A chymotrypsin homologue isolated from Achromobacter lyticus.
            Enzymes with similar specificity are produced by Lysobacter
            enzymogenes (Endoproteinase Lys-C) and Pseudomonas aeruginosa
            (Ps-1).
COMMENT     Also hydrolyses lysine amides and esters.
GENES       MJA: MJ1468
            MTH: MTH995
STRUCTURES  PDB: 1ARC  1ARB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.50
            ExPASy - ENZYME nomenclature database: 3.4.21.50
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.50
            BRENDA, the Enzyme Database: 3.4.21.50
            SCOP (Structural Classification of Proteins): 3.4.21.50
///
ENTRY       EC 3.4.21.51
NAME        Deleted entry
            Leukocyte-membrane neutral endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.51
            ExPASy - ENZYME nomenclature database: 3.4.21.51
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.51
///
ENTRY       EC 3.4.21.52
NAME        Deleted entry
            Cathepsin R
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.52
            ExPASy - ENZYME nomenclature database: 3.4.21.52
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.52
///
ENTRY       EC 3.4.21.53
NAME        Endopeptidase La
            ATP-dependent serine proteinase
            Lon proteinase
            Protease La
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins in presence of ATP
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Vanadate
COMMENT     Product of the lon gene, in E. coli. ATP hydrolysis is linked
            with peptide bond hydrolysis; vanadate inhibits both reactions.
            Not a homologue of chymotrypsin or subtilisin. A similar enzyme
            occurs in animal mitochondria.
GENES       ECO: b0439(lon)
            ECE: Z0545(lon)
            ECS: ECs0493
            YPE: YPO3155(lon)
            HIN: HI0462(lon)
            PMU: PM1978(lon)
            XFA: XF1189
            VCH: VC1920
            PAE: PA0779 PA1803(lon)
            BUC: BU477(lon)
            NME: NMB1231
            NMA: NMA1398(lon)
            HPY: HP1379(lon)
            HPJ: jhp1293
            CJE: Cj1073c(lon)
            RPR: RP450(lon)
            RCO: RC0629(lon)
            MLO: mlr8476
            SME: SMc01905(lon)
            CCR: CC1960
            BSU: BG10338(lonA)
            BHA: BH3050(lonA)
            CAC: CAC0456(lonA) CAC2637(lonA)
            MGE: MG239(lon)
            MPN: F10_orf795(lon)
            MPU: MYPU_5190(lon)
            UUR: UU348(lon)
            CTR: CT344
            CMU: TC0623
            CPN: CPn0027
            CPA: CP0749
            CPJ: lon
            BBU: BB0253(lon-1)
            TPA: TP0016 TP0524
            SYN: sll0195
            DRA: DR0349 DR1974
            AAE: aq_242(lon)
            TMA: TM1633
            MJA: MJ1417(lon)
            MTH: MTH785 MTH892
            AFU: AF0364(lon)
            HAL: VNG0303G(lon)
            TAC: Ta1081
            TVO: TVG0479569
            PAB: PAB1313(lon)
            CEL: C34B2.6
MOTIF       PS: PS01046  D-G-[PD]-S-A-[GS]-[LIVMCA]-[TA]-[LIVM]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.53
            ExPASy - ENZYME nomenclature database: 3.4.21.53
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.53
            BRENDA, the Enzyme Database: 3.4.21.53
///
ENTRY       EC 3.4.21.54
NAME        gamma-Renin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of the Leu-|-Leu bond in synthetic tetradecapeptide renin
            substrate (horse), to produce angiotensin I, but not active on
            natural angiotensinogen, unlike renin (EC 3.4.23.15).  Also
            hydrolyses Bz-Arg-p-nitroanilide
SUBSTRATE   N-Benzoyl-D-arginine-4-nitroanilide
            H2O
COMMENT     A member of the tissue kallikrein family, from submandibular
            glands of male mice.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.54
            ExPASy - ENZYME nomenclature database: 3.4.21.54
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.54
            BRENDA, the Enzyme Database: 3.4.21.54
///
ENTRY       EC 3.4.21.55
NAME        Venombin AB
            Bitis gabonica serine proteinase
            Gabonase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage at Arg+ bonds in fibrinogen to form fibrin and
            release fibfinopeptides A and B
SUBSTRATE   Fibrinogen
            H2O
PRODUCT     Fibrin
            Fibfinopeptides A
            Fibfinopeptides B
COMMENT     From the venom of the Gaboon viper Bitis gabonica. Activates
            Factor XIII.  Not inhibited by antithrombin III/heparin or
            hirudin, unlike EC 3.4.21.5.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.55
            ExPASy - ENZYME nomenclature database: 3.4.21.55
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.55
            BRENDA, the Enzyme Database: 3.4.21.55
///
ENTRY       EC 3.4.21.56
NAME        Deleted entry
            Euphorbain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.56
            ExPASy - ENZYME nomenclature database: 3.4.21.56
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.56
            BRENDA, the Enzyme Database: 3.4.21.56
///
ENTRY       EC 3.4.21.57
NAME        Leucyl endopeptidase
            Plant leu-proteinase
            Leucine-specific serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins. Preferential cleavage: Leu+ in small
            molecule substrates
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     From leaves of the spinach plant (Spinacia oleracea).
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.57
            ExPASy - ENZYME nomenclature database: 3.4.21.57
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.57
            BRENDA, the Enzyme Database: 3.4.21.57
///
ENTRY       EC 3.4.21.58
NAME        Deleted entry
            Prohormone serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.58
            ExPASy - ENZYME nomenclature database: 3.4.21.58
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.58
///
ENTRY       EC 3.4.21.59
NAME        Tryptase
            Mast cell tryptase
            Mast cell protease II
            Skin tryptase
            Lung tryptase
            Pituitary tryptase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Arg+, Lys+, but with more restricted
            specificity than trypsin
SUBSTRATE   Peptide
            Protein
PRODUCT     Peptide
            Protein
COMMENT     Occurs as a tetrameric molecule with high affinity for heparin, in
            mast cell granules. A homologue of chymotrypsin. Not inhibited by
            alpha1-proteinase inhibitor or alpha2-macroglobulin.
GENES       HSA: 25823(TPSG1) 64499(TPSB2) 7176(TPS1) 7177(TPSB1)
DISEASE     MIM: 191080  Tryptase, alpha
            MIM: 191081  Tryptase, beta
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1AAO  1A0L  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.59
            ExPASy - ENZYME nomenclature database: 3.4.21.59
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.59
            BRENDA, the Enzyme Database: 3.4.21.59
            SCOP (Structural Classification of Proteins): 3.4.21.59
///
ENTRY       EC 3.4.21.60
NAME        Scutelarin
            Taipan activator
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg-|-Thr and Arg-|-Ile in prothrombin to
            form thrombin and two inactive fragments
SUBSTRATE   Prothrombin
            H2O
PRODUCT     Thrombin
EFFECTOR    Phospholipid
            Calcium
COMMENT     From the venom of the Taipan snake (Oxyuranus scutellatus).
            Converts prothrombin to thrombin in the absence of coagulation
            Factor Va, and is potentiated by phospholipid and Ca2+.
            Specificity is similar to that of Factor Xa.  Binds Ca2+ via
            gamma-carboxylglutamic acid residues.  Formerly EC 3.4.99.28.
            Similar enzymes are known from the venom of other Australian
            elapid snakes Pseudonaja textilis textilis, Oxyuranus
            microleidotus and Demansia nuchalis affinis.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.60
            ExPASy - ENZYME nomenclature database: 3.4.21.60
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.60
            BRENDA, the Enzyme Database: 3.4.21.60
///
ENTRY       EC 3.4.21.61
NAME        Kexin
            Yeast KEX2 protease
            Proteinase yscF
            Prohormone-processing endoprotease
            Paired-basic endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of -Lys-Arg+ and Arg-Arg+ bonds to process yeast
            alpha-factor pheromone and killer toxin precursors
SUBSTRATE   Yeast alpha-factor pheromone
            Killer toxin precursor
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   p-Mercuribenzoate
COFACTOR    Calcium
COMMENT     A Ca2+-activated subtilisin homologue, containing Cys near the
            active site His, and inhibited by p-mercuribenzoate.  Similar
            enzymes occur in mammals.  Formerly EC 3.4.22.23.
GENES       SCE: YNL238W(KEX2)
            MMU: 97514(Pcsk4)
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.61
            ExPASy - ENZYME nomenclature database: 3.4.21.61
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.61
            BRENDA, the Enzyme Database: 3.4.21.61
///
ENTRY       EC 3.4.21.62
NAME        Subtilisin
            Subtilisin BPN'
            Subtilisin B
            Subtilopeptidase B
            Subtilopeptidase C
            Nagarse
            Nagarse proteinase
            Subtilisin Novo
            Bacterial proteinase Novo
            Subtilisin Carlsberg
            Subtilisin A
            Subtilopeptidase A
            Alcalase Novo
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            and a preference for a large uncharged residue in P1.  Hydrolyses
            peptide amide
SUBSTRATE   Peptide
            Protein
            H2O
PRODUCT     Peptide
            Protein
COMMENT     Subtilisin is a serine endopeptidase that evolved independently of
            chymotrypsin.  It contains no cysteine residues (although these
            are found in homologous enzymes).  Species variants include
            subtilisin BPN' (also subtilisin B, subtilopeptidase B,
            subtilopeptidase C, Nagarse, Nagarse proteinase, subtilisin Novo,
            bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A,
            subtilopeptidase A, alcalase Novo).  Formerly EC 3.4.4.16 and
            included in EC 3.4.21.14.  Similar enzymes are produced by various
            Bacillus subtilis strains and other Bacillus species.
GENES       BSU: BG10190(aprE)
            BHA: BH0684(alp)
            MPU: MYPU_6550
            DME: CG6438(amon)
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
STRUCTURES  PDB: 1SBI  1C9M  1C9N  1CSE  1DUI  1GCI  1IAV  1JEA  1MPT  1SBC  
                 1SBH  1SBN  1SCA  1SCB  1SCD  1SCJ  1C3L  1SIB  1SPB  1ST3  
                 1C9J  1SUA  1SUC  1SUD  1SUE  1SUP  1SVN  1UBN  1VSB  2SEC  
                 3SIC  3VSB  5SIC  1BH6  1BFU  1BFK  1BE8  1BE6  1AVT  1AV7  
                 1AU9  1SUB  1SCN  1AQN  1A2Q  1AF4  1AK9  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.62
            ExPASy - ENZYME nomenclature database: 3.4.21.62
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.62
            BRENDA, the Enzyme Database: 3.4.21.62
            SCOP (Structural Classification of Proteins): 3.4.21.62
///
ENTRY       EC 3.4.21.63
NAME        Oryzin
            Aspergillus alkaline proteinase
            Aspergillopeptidase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity, and of
            Bz-Arg-OEt > Ac-Tyr-OEt.  Does not hydrolyse peptide amides
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A subtilisin homologue, not containing cysteine, that is the
            predominant extracellular alkaline endopeptidase of the mould
            Aspergillus oryzae.  Formerly EC 3.4.21.15, and included in
            EC 3.4.21.14.  Identical or closely related enzymes are produced
            by A. flavus and A. sojae.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.63
            ExPASy - ENZYME nomenclature database: 3.4.21.63
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.63
            BRENDA, the Enzyme Database: 3.4.21.63
///
ENTRY       EC 3.4.21.64
NAME        Endopeptidase K
            Tritirachium alkaline proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of keratin, and of other proteins with subtilisin-like
            specificity.  Hydrolyses peptide amides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the mould Tritirachium album Limber.  A homologue of
            subtilisin containing two disulfide bridges and one free Cys near
            the active site His.  Formerly included in EC 3.4.21.14.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
STRUCTURES  PDB: 1PTK  1IC6  1HT3  1CNM  1BJR  1EGQ  3PRK  2PKC  1PEK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.64
            ExPASy - ENZYME nomenclature database: 3.4.21.64
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.64
            BRENDA, the Enzyme Database: 3.4.21.64
            SCOP (Structural Classification of Proteins): 3.4.21.64
///
ENTRY       EC 3.4.21.65
NAME        Thermomycolin
            Thermomycolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Rather nonspecific hydrolysis of proteins.  Preferential cleavage:
            Ala+, Tyr+, Phe+ in small molecule substrates
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A homologue of subtilisin from the thermophilic fungus Malbranchea
            pulchella var.  sulfurea containing Cys, but knot inhibited by
            p-mercuribenzoate.  Very thermostable.  Formerly included in
            EC 3.4.21.14.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.65
            ExPASy - ENZYME nomenclature database: 3.4.21.65
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.65
            BRENDA, the Enzyme Database: 3.4.21.65
///
ENTRY       EC 3.4.21.66
NAME        Thermitase
            Thermophilic Streptomyces serine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including collagen
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   p-Mercuribenzoate
COMMENT     A homologue of subtilisin from Thermoactinomyces vulgaris
            containing a single Cys, near the active site His, and inhibited
            by p-mercuribenzoate.  The N-terminal extension of the polypeptide
            chain relative to subtilisin contributes to Ca2+-binding and the
            high thermostability.  The amino acid composition and properties
            of the thermostable enzyme from Streptomyces rectus var.
            proteolyticus (formerly included in EC 3.4.21.14) are closely
            similar.
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
STRUCTURES  PDB: 1THM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.66
            ExPASy - ENZYME nomenclature database: 3.4.21.66
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.66
            BRENDA, the Enzyme Database: 3.4.21.66
            SCOP (Structural Classification of Proteins): 3.4.21.66
///
ENTRY       EC 3.4.21.67
NAME        Endopeptidase So
            E. coli cytoplasmic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of protiens, but not Bz-Tyr-OET, Ac-Phe-beta-naphthyl-
            ester, or Bz-Arg-OEt.
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
INHIBITOR   Tos-Ph-CH2Cl
COMMENT     An E. coli cytoplasmic endopeptidase formerly included in
            EC 3.4.21.14.  Inihibited by Tos-Ph-CH2Cl, but not by
            Tos-Lys-CH2Cl.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.67
            ExPASy - ENZYME nomenclature database: 3.4.21.67
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.67
///
ENTRY       EC 3.4.21.68
NAME        t-Plasminogen activator
            Tissue plasminogen activator
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin
SUBSTRATE   Plasminogen
PRODUCT     Plasmin
EFFECTOR    Fibrin
COMMENT     A homologue of chymotrypsin from a wide variety of mammalian
            tissues, especially endothelial cells.  Secreted as a single chain
            precursor which is cleaved to a two-chain form by plasmin.
            Activity is considerably enhanced by fibrin.  Formerly included in
            EC 3.4.21.31 and 3.4.99.26.
GENES       MMU: 97610(Plat)
            HSA: 5327(PLAT)
DISEASE     MIM: 173370  Plasminogen activator, tissue type
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01253  C-x(6,8)-[LFY]-x(5)-[FYW]-x-[RK]-x(8,10)-C-x-C-x(6,9)-C
            PS: PS50070  Kringle domain profile
STRUCTURES  PDB: 1PML  1PK2  1BDA  1A5H  1A5I  1RTF  1TPG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.68
            ExPASy - ENZYME nomenclature database: 3.4.21.68
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.68
            BRENDA, the Enzyme Database: 3.4.21.68
            SCOP (Structural Classification of Proteins): 3.4.21.68
///
ENTRY       EC 3.4.21.69
NAME        Protein C (activated)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Degradation of blood coagulation Factors Va and VIIIa
SUBSTRATE   Blood coagulation Factor Va
            Blood coagulation Factor VIIIa
PRODUCT     Peptide
COMMENT     One of the gamma-carboxyglutamic acid-containing cagulation
            factors. Formed from protein C, the proenzyme that circulates in
            plasma, by the action of a complex of thrombin with
            thrombomodulin, or by serine endopeptidases present in several
            snake venoms.
GENES       HSA: 5624(PROC)
DISEASE     MIM: 176860  Protein C (inactivator of coagulation factors Va and
                         VIIIa)
MOTIF       PS: PS00010  C-x-[DN]-x(4)-[FY]-x-C-x-C
            PS: PS00011  x(12)-E-x(3)-E-x-C-x(6)-[DEN]-x-[LIVMFY]-x(9)-[FYW]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS01187  [DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]-x(4)-
                         [FY]-x-C
STRUCTURES  PDB: 2PCT  1PCU  1AUT  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.69
            ExPASy - ENZYME nomenclature database: 3.4.21.69
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.69
            BRENDA, the Enzyme Database: 3.4.21.69
            SCOP (Structural Classification of Proteins): 3.4.21.69
///
ENTRY       EC 3.4.21.70
NAME        Pancreatic endopeptidase E
            Cholesterol-binding proteinase
            Elastase III
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Ala+.  Does not hydrloyse elastin
SUBSTRATE   Peptide
            H2O
PRODUCT     Peptide
COMMENT     A homologue of chymotrypsin from pancreatic juice.  Unlike
            elastases, has an acidic pI.  Binds cholesterol.
GENES       HSA: 10136(ELA3) 23436(ELA3B)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.70
            ExPASy - ENZYME nomenclature database: 3.4.21.70
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.70
            BRENDA, the Enzyme Database: 3.4.21.70
///
ENTRY       EC 3.4.21.71
NAME        Pancreatic elastase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Leu+, Met+ and Phe+.  Hydrolyses elastin
SUBSTRATE   Elastin
            H2O
PRODUCT     Peptide
COMMENT     Formed by activation of proelastase II from mammlian pancreas by
            trypsin. Usually, only one of the pancreatic elastases (see also
            EC 3.4.21.36) is expressed in a given species; human pancreatic
            elastase is of type II.
GENES       HSA: 1990(ELA1) 51032(LOC51032)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1BRU  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.71
            ExPASy - ENZYME nomenclature database: 3.4.21.71
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.71
            BRENDA, the Enzyme Database: 3.4.21.71
            SCOP (Structural Classification of Proteins): 3.4.21.71
///
ENTRY       EC 3.4.21.72
NAME        IgA-specific serine endopeptidase
            IgA protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of immunoglobulin A molecules at certain Pro+ bonds in
            the hinge region.  No small molecule substrates are known
            IgA protease
SUBSTRATE   Immunoglobulin A
            H2O
PRODUCT     Peptide
COMMENT     Species variants differing slightly in specificity are secreted by
            Gram negative bacteria Neisseria gonorrhoeae and Haemophilus
            influenzae.  Distant homologue of chymotrypsin. Some other
            bacterial endopeptidases with similar specificity are of
            metallo-type (see EC 3.4.24.13).
GENES       HIN: HI0990(IgA)
            NME: NMB0700
            NMA: NMA0457(iga2) NMA0905(iga)
            CJE: Cj0223
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.72
            ExPASy - ENZYME nomenclature database: 3.4.21.72
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.72
            BRENDA, the Enzyme Database: 3.4.21.72
///
ENTRY       EC 3.4.21.73
NAME        u-Plasminogen activator
            Urokinase
            Urinary plasminogen activator
            Cellular plasminogen activator
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin
SUBSTRATE   Plasminogen
PRODUCT     Plasmin
COMMENT     Formed from the inactive precursor by action of plasmin or plasma
            kallikrein.  Differs in structure from t-plasminogen activator
            (EC 3.4.21.68), and does not bind to fibrin.  A homologue of
            chymotrypsin.  Formerly included in EC 3.4.21.31 and 3.4.99.26.
GENES       MMU: 97611(Plau)
            HSA: 5328(PLAU)
DISEASE     MIM: 191840  Plasminogen activator, urokinase
MOTIF       PS: PS00021  [FY]-C-R-N-P-[DNR]
            PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS50070  Kringle domain profile
STRUCTURES  PDB: 1C5X  1C5Y  1C5Z  1EJN  1F5K  1F5L  1F92  1FV9  1LMW  1C5W  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.73
            ExPASy - ENZYME nomenclature database: 3.4.21.73
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.73
            BRENDA, the Enzyme Database: 3.4.21.73
            SCOP (Structural Classification of Proteins): 3.4.21.73
///
ENTRY       EC 3.4.21.74
NAME        Venombin A
            Ancrod
            Batroxobin
            Crotalase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of Arg+ bond in fibrinogen, to form fibrin, and
            release fibrinopeptide A.  The specificity of further degradation
            of fibrinogen varies with species origin of the enzyme
SUBSTRATE   Fibrinogen
PRODUCT     Fibrin
            Fibrinopeptide A
COMMENT     A somewhat thrombin-like enzyme from vinoms of snakes of the
            viper/rattlesnake group. Species variants of the enzyme include
            ancrod from Agkistrodon rhodostoma (Malayan pit viper) (formerly
            EC 3.4.21.28), batroxobin from Bothrops atrox (South American pit
            viper) (formerly EC 3.4.21.29) and crotalase from Crotalus
            adamanteus (Eastern diamondback rattlesnake) (formerly EC
            3.4.21.30).  A homolgue of chymotrypsin.  Does not require
            activation by Ca2+.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.74
            ExPASy - ENZYME nomenclature database: 3.4.21.74
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.74
            BRENDA, the Enzyme Database: 3.4.21.74
///
ENTRY       EC 3.4.21.75
NAME        Furin
            Paired basic amino acid residue cleaving enzyme
            Prohormone convertase
            Dibasic processing enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Release of mature proteins from their proproteins by cleavage of
            Arg or Lys. Releases Albumin, complement component C3 and VON
            WILLEBRAND factor from their respective precursors.
COMMENT     Activated by Calcium.
            Belongs to peptidase family S8.
GENES       CEL: F11A6.1a F11A6.1b
            DME: CG10772(Fur1) CG10772_1(Fur1)
            HSA: 5045(PACE)
DISEASE     MIM: 136950  Paired basic amino acid cleaving enzyme (furin
                         membrane-associated
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.75
            ExPASy - ENZYME nomenclature database: 3.4.21.75
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.75
            BRENDA, the Enzyme Database: 3.4.21.75
///
ENTRY       EC 3.4.21.76
NAME        Myeloblastin
            Proteinase 3
            WEGENER's autoantigen
            Leukocyte proteinase 3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including Elastin, by preferential cleavage:
            Ala-|-Xaa > Val-|-Xaa.
COMMENT     Not inhibited by secretory Leukocyte proteinase inhibitor.
            Belongs to peptidase family S1.
GENES       HSA: 5657(PRTN3)
DISEASE     MIM: 177020  Proteinase-3 (serine proteinase, neutrophil, Wegener
                         granulomatosis
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.76
            ExPASy - ENZYME nomenclature database: 3.4.21.76
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.76
            BRENDA, the Enzyme Database: 3.4.21.76
///
ENTRY       EC 3.4.21.77
NAME        Semenogelase
            Prostate specific antigen
            gamma-Seminoprotein
            Seminin
            P-30 Antigen
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Tyr-|-Xaa
COMMENT     Slowly inhibitted by alpha-1-Antichymotrypsin.
            Belongs to peptidase family S1.
GENES       HSA: 354(KLK3)
DISEASE     MIM: 176820  Kallikrein 3, (prostate specific antigen)
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 2PSA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.77
            ExPASy - ENZYME nomenclature database: 3.4.21.77
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.77
            BRENDA, the Enzyme Database: 3.4.21.77
            SCOP (Structural Classification of Proteins): 3.4.21.77
///
ENTRY       EC 3.4.21.78
NAME        Granzyme A
            Cytotoxic t-lymphocyte proteinase 1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins, including Fibronectin, TYPE IV Collagen and
            Nucleolin. Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa >> Phe-|-Xaa
            in small molecule substrates.
COMMENT     From Cytotoxic T lymphocytes granules.
            The human enzyme does not cleave Phe-|-Xaa.
            Belongs to peptidase family S1.
GENES       MMU: 109266(Gzma)
            HSA: 3001(GZMA)
DISEASE     MIM: 140050  Granzyme A (Cytotoxic T-lymphocyte-associated serine
                         esterase-3;
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.78
            ExPASy - ENZYME nomenclature database: 3.4.21.78
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.78
            BRENDA, the Enzyme Database: 3.4.21.78
///
ENTRY       EC 3.4.21.79
NAME        Granzyme B
            Cytotoxic t-lymphocyte proteinase 2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Asp-|-Xaa >> Asn-|-Xaa > Met-|-Xaa,
            Ser-|-Xaa.
COMMENT     From Cytotoxic T lymphocytes granules.
            Belongs to peptidase family S1.
GENES       MMU: 109267(Gzmb)
            HSA: 3002(GZMB)
DISEASE     MIM: 123910  Granzyme B (cytotoxic T-lymphocyte-associated serine
                         esterase-1;
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1IAU  1FQ3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.79
            ExPASy - ENZYME nomenclature database: 3.4.21.79
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.79
            BRENDA, the Enzyme Database: 3.4.21.79
            SCOP (Structural Classification of Proteins): 3.4.21.79
///
ENTRY       EC 3.4.21.80
NAME        Streptogrisin A
            Streptomyces protease A
            SPGA
            Pronase enzyme A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with specificity similar to Chymotrypsin.
COMMENT     Not inhibited by Tos-Phe-CH2Cl or Ovomucoid.
            Belongs to peptidase family S2A.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.80
            ExPASy - ENZYME nomenclature database: 3.4.21.80
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.80
            BRENDA, the Enzyme Database: 3.4.21.80
///
ENTRY       EC 3.4.21.81
NAME        Streptogrisin B
            Streptomyces protease B
            SGPB
            Pronase enzyme B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins with specificity similar to Trypsin.
COMMENT     Belongs to peptidase family S2A.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1CSO  1CT0  1CT2  1CT4  1DS2  1SGP  1SGQ  1SGR  2SGP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.81
            ExPASy - ENZYME nomenclature database: 3.4.21.81
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.81
            BRENDA, the Enzyme Database: 3.4.21.81
            SCOP (Structural Classification of Proteins): 3.4.21.81
///
ENTRY       EC 3.4.21.82
NAME        Glutamyl endopeptidase II
            Glutamic acid-specific protease
            GLUSGP
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Glu-|-Xaa. Preference for Pro or
            Leu at P2 and Phe at P3. Cleavage of Glu-|-Pro and Asp-|-Pro bonds
            is slow.
COMMENT     Inhibited by [Leu(18)->Glu] modified turkey Ovomucoid third domain.
            Belongs to peptidase family S2A.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
STRUCTURES  PDB: 1HPG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.82
            ExPASy - ENZYME nomenclature database: 3.4.21.82
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.82
            BRENDA, the Enzyme Database: 3.4.21.82
            SCOP (Structural Classification of Proteins): 3.4.21.82
///
ENTRY       EC 3.4.21.83
NAME        Oligopeptidase B
            Protease II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of Arg-|-Xaa and Lys-|-Xaa bonds in Oligopeptides, even
            when P1' residue is Proline.
COMMENT     Inhibited by Tos-Lys-CH2Cl.
            Belongs to peptidase family S9A.
GENES       ECO: b1845(ptrB)
            ECE: Z2896(ptrB)
            ECS: ECs2555
            YPE: YPO1780(ptrB)
            XFA: XF1479
            VCH: VCA0063
            PAE: PA1304
            RPR: RP281(ptrB)
            RCO: RC0377(ptrB)
            MLO: mll7643
            SME: SMc00114(ptrB)
            SPR: spr1204(ptrB)
            MTU: Rv0782
            MTC: MT0805
            MLE: ML2226(ptrB)
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.83
            ExPASy - ENZYME nomenclature database: 3.4.21.83
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.83
            BRENDA, the Enzyme Database: 3.4.21.83
///
ENTRY       EC 3.4.21.84
NAME        Limulus clotting factor C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds
            in Limulus Clotting Factor B to form activated Factor B. Cleavage of
            Pro-Arg-|-Xaa bonds in synthetic substrates.
COMMENT     From the Hemocyte granules of the Horseshoe crabs Limulus and
            Tachypleus.
            Factor C is activated by Gram-negative bacterial Lipopolysaccharides
            and Chymotrypsin.
            Inhibited by Antithrombin III.
            Belongs to peptidase family S1.
MOTIF       PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
            PS: PS00615  C-[LIVMFYATG]-x(5,12)-[WL]-x-[DNSR]-x(2)-C-x(5,6)-
                         [FYWLIVSTA]-[LIVMSTA]-C
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS50041  C-type lectin domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.84
            ExPASy - ENZYME nomenclature database: 3.4.21.84
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.84
            BRENDA, the Enzyme Database: 3.4.21.84
///
ENTRY       EC 3.4.21.85
NAME        Limulus clotting factor B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of 98-Arg-|-Ile-99 bond in Limulus proclotting
            enzyme to form active clotting enzyme.
COMMENT     From the Hemocyte granules of the Horseshoe crabs Limulus and
            Tachypleus.
            Factor B is activated by Factor C.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.85
            ExPASy - ENZYME nomenclature database: 3.4.21.85
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.85
            BRENDA, the Enzyme Database: 3.4.21.85
///
ENTRY       EC 3.4.21.86
NAME        Limulus clotting enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective cleavage of 18-Arg-|- and 47-Arg-|- bonds in Coagulagen
            to form Coagulin and fragments.
COMMENT     From the Hemocyte granules of the Horseshoe crabs Limulus and
            Tachypleus.
            Limulus clotting enzyme is activated by Factor B.
            Belongs to peptidase family S1.
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.86
            ExPASy - ENZYME nomenclature database: 3.4.21.86
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.86
            BRENDA, the Enzyme Database: 3.4.21.86
///
ENTRY       EC 3.4.21.87
NAME        Omptin
            Protease VII
            Protease A
            Outer membrane 3B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Preferential cleavage: Xaa-|-Yaa in which both Xaa and Yaa are Arg
            or Lys.
COMMENT     Belongs to peptidase family S18.
GENES       ECO: b0565(ompT)
            ECE: Z1931
            ECS: ECs1663
MOTIF       PS: PS00834  W-T-D-x-S-x-H-P-x-T
            PS: PS00835  A-G-Y-Q-E-[ST]-R-[FYW]-S-[FYW]-[TN]-A-x-G-G-[ST]-Y
STRUCTURES  PDB: 1I78  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.87
            ExPASy - ENZYME nomenclature database: 3.4.21.87
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.87
            BRENDA, the Enzyme Database: 3.4.21.87
///
ENTRY       EC 3.4.21.88
NAME        Repressor LEXA
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of 84-Ala-|-Gly-85 bond in reprecursor LEXA.
COMMENT     In the presence of Single-stranded DNA, the RECA protein interacts
            with LEXA cousing an autocatalytic cleavage which disrupts the DNA-
            binding part of LEXA, leading to derepression of the SOS regulon
            and eventually DNA repair.
            The activity was previosly attributed to the RECA protein (formerly
            EC 3.4.99.37).
            Belongs to peptidase family S24.
GENES       ECO: b4043(lexA)
            ECE: Z5642(lexA)
            ECS: ECs5026
            YPE: YPO0314(lexA)
            HIN: HI0749(lexA)
            PMU: PM1181(lexA)
            XFA: XF0122
            VCH: VC0092
            PAE: PA3007(lexA)
            MLO: mlr0626
            SME: SMc01183(lexA)
            CCR: CC1902
            BSU: BG10678(lexA)
            BHA: BH2356(lexA)
            SAU: SA1174(lexA)
            SAV: SAV1324(lexA)
            SPR: spr1757(recA)
            CAC: CAC1832(lexA)
            MTU: Rv2720(lexA)
            MTC: MT2793
            MLE: ML1003(lexA)
            SYN: sll1626(lexA)
            DRA: DRA0344
            TMA: TM1082
STRUCTURES  PDB: 1JHC  1JHE  1JHF  1JHH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.88
            ExPASy - ENZYME nomenclature database: 3.4.21.88
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.88
            BRENDA, the Enzyme Database: 3.4.21.88
///
ENTRY       EC 3.4.21.89
NAME        Signal peptidase I
            Bacterial leader peptidase I
            SPase I
            Phage-procoat-leader peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Cleavage of N-terminal leader sequences from secreted and
            periplasmic proteins precursor.
COMMENT     Unaffected by inhibitors of most serine peptidases.
            Cleaves a single bond Ala-|-Ala in M13 Phage procoat protein.
            Creates signal (leader) peptide and coat protein.
            The characteristics of the P1 and P3 residues are especially
            important in the specificity of leader peptidase.
            Belongs to peptidase family S26.
PATHWAY     PATH: MAP03060  Protein export
GENES       ECO: b2568(lepB)
            ECE: Z3850(lepB)
            ECS: ECs3434
            YPE: YPO2717(lepB)
            HIN: HI0015(lepB)
            PMU: PM0062(lepB)
            XFA: XF2244
            VCH: VC2462
            PAE: PA0768(lepB) PA1303
            BUC: BU259(lepB)
            NME: NMB0765
            NMA: NMA0976(lepB)
            HPY: HP0576(lepB)
            HPJ: jhp0523
            CJE: Cj0856(lepP)
            RPR: RP116(lepB)
            RCO: RC0156(lepB)
            MLO: mlr7763
            SME: SMc02653(lepB)
            CCR: CC1559 CC2150
            BSU: BG10515(sipS) BG11223(sipU) BG11696(sipW) BG11977(sipT)
                 BG12674(sipV)
            BHA: BH1030(sipV) BH2130(sipW)
            SAU: SA0825(spsA) SA0826(spsB)
            SAV: SAV0951(spsA) SAV0952(spsB)
            LLA: L0337(sipL)
            SPY: SPy1281(sipC) SPy1842(spi)
            SPN: SP0402
            SPR: spr0364(spi)
            CAC: CAC1760 CAC2646(sipS)
            MPU: MYPU_6300(sipS)
            MTU: Rv2903c(lepB)
            MTC: MT2971
            MLE: ML1612
            CTR: CT020
            CMU: TC0289
            CPN: CPn0110
            CPA: CP0664
            CPJ: lepB
            BBU: BB0030(lepB-1) BB0031(lepB-2) BB0263(lepB-3)
            TPA: TP0185 TP0926
            SYN: sll0716(lepB) slr1377(lepB)
            DRA: DR1321 DR1427 DR1737
            AAE: aq_955(lepB)
            TMA: TM1572
            ATH: At1g52600(F6D8.18)
            DME: CG2358(BcDNA:GM04682)
            HSA: 23478(SPC18)
MOTIF       PS: PS00501  [GS]-x-S-M-x-[PS]-[AT]-[LF]
            PS: PS00760  K-R-[LIVMSTA](2)-[GA]-x-[PG]-G-[DE]-x-[LIVM]-x-[LIVMFY]
            PS: PS00761  [LIVMFYW](2)-x(2)-G-D-[NH]-x(3)-[SND]-x(2)-[SG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.89
            ExPASy - ENZYME nomenclature database: 3.4.21.89
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.89
            BRENDA, the Enzyme Database: 3.4.21.89
///
ENTRY       EC 3.4.21.90
NAME        Togavirin
            Sindbis virus protease
            NSP2 proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Autocatalytic release of the core protein from the N-Terminus of the
            Togavirus structual protein by hydrolysis of a Trp-|-Ser bond.
COMMENT     Once released, the core protein does not retain catalytic activity.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.90
            ExPASy - ENZYME nomenclature database: 3.4.21.90
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.90
            BRENDA, the Enzyme Database: 3.4.21.90
///
ENTRY       EC 3.4.21.91
NAME        Flabirin
            Yellow fever virus protease
            NS2B-3 proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Selective hydrolysis of Xaa-|-Xaa-|-Xbb bonds in which each of the
            Xaa can be either Arg or Lys and Xbb can be either Ser or Ala.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.91
            ExPASy - ENZYME nomenclature database: 3.4.21.91
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.91
            BRENDA, the Enzyme Database: 3.4.21.91
///
ENTRY       EC 3.4.21.92
NAME        Endopeptidase CLP
            Endopeptidase TI
            Protease TI
            Caseinolytic protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Hydrolysis of proteins to small peptides in the presence of ATP and
            Magnesium. alpha-Casein is the usual test substrate. In the absence
            of ATP, only Oligopeptides shorter than five residues are cleaved
            (such as Succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in
            which the cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp- bond also
            occurs).
COMMENT     Belongs to peptidase family S14.
GENES       ECO: b0437(clpP)
            ECE: Z0542(clpP)
            ECS: ECs0491
            YPE: YPO3157(clpP)
            HIN: HI0714(clpP)
            PMU: PM1976(clpP)
            XFA: XF1187
            VCH: VC1922
            PAE: PA1801(clpP) PA3326
            BUC: BU475(clpP)
            NME: NMB1312
            NMA: NMA1525(clpP)
            HPY: HP0794(clpP)
            HPJ: jhp0730
            CJE: Cj0192c(clpP)
            RPR: RP520(clpP)
            RCO: RC0746(clpP)
            MLO: mlr0748 mlr8472
            SME: SMc01903(clpP1) SMc03841(clpP3)
            CCR: CC1963
            BSU: BG19016(clpP)
            BHA: BH3118 BH3564(clpP)
            SAU: SA0723(clpP)
            SAV: SAV0755(clpP)
            LLA: L72391(clpP)
            SPY: SPy0395(clpP)
            SPN: SP0746
            SPR: spr0656(clpP)
            CAC: CAC2640(clpP)
            MTU: Rv2460c(clpP2) Rv2461c(clpP)
            MTC: MT2535 MT2536
            MLE: ML1479(clpP2) ML1480(clpP)
            CTR: CT431 CT706
            CMU: TC0079 TC0715
            CPN: CPn0520 CPn0847
            CPA: CP0233 CP1022
            CPJ: clpP_1 clpP_2
            BBU: BB0611(clpP-1) BB0757(clpP-2)
            TPA: TP0507 TP1041
            SYN: sll0534(clpP2) slr0164(clpP4) slr0165(clpP3) slr0542(clpP1)
            DRA: DR1972
            AAE: aq_1339(clpP)
            TMA: TM0695
            CEL: ZK970.2
            DME: CG5045
            HSA: 8192(CLPP)
DISEASE     MIM: 601119  ATP-dependent protease ClpAP, E. coli, proteolytic
                         subunit, homolog of
MOTIF       PS: PS00381  T-x(2)-[LIVMF]-G-x-A-[SAC]-S-[MSA]-[PAG]-[STA]
            PS: PS00382  R-x(3)-[EAP]-x(3)-[LIVMFYT]-[LM]-[LIVM]-H-Q-P
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
STRUCTURES  PDB: 1TYF  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.92
            ExPASy - ENZYME nomenclature database: 3.4.21.92
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.92
            BRENDA, the Enzyme Database: 3.4.21.92
            SCOP (Structural Classification of Proteins): 3.4.21.92
///
ENTRY       EC 3.4.21.93
NAME        Prohormone convertase I
            Neuroendocrine convertase 1
            NEC 1
            PC 1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Release of protein hormones and Renin from their precursors,
            generally by cleavage of -Lys-Arg-|- bonds.
COMMENT     A Calcium dependent enzyme, maximally active at about PH 5.5.
            Substrates include Pro-opiomelanocortin, Prorenin, Proenkephalin,
            Prodynorphin, Prosomatostatin and Proinsulin. Unlike Prohormone
            convertase 2, does not cleave Proluteinizing-hormone-releasing
            hormone.
            Usually processing of Prodnyorphin occurs at a bond in which P2
            is Thr.
            Present in the regulated secretory pathway of neuroendocrine cells,
            commonly actin co-cperatively with Prohormone convertase 2.
            Belongs to peptidase family S8.
GENES       MMU: 97511(Pcsk1)
            HSA: 5122(PCSK1)
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.93
            ExPASy - ENZYME nomenclature database: 3.4.21.93
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.93
            BRENDA, the Enzyme Database: 3.4.21.93
///
ENTRY       EC 3.4.21.94
NAME        Prohormone convertase II
            Neuroendocrine convertase 2
            NEC 2
            PC2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Release of protein hormones from their precursors, generally by
            cleavage of -Lys-Arg-|- bonds.
COMMENT     A Calcium dependent enzyme, maximally active at about PH 5.5.
            Specificity is broader than that of Prohormone convertase 1.
            Substrates include Pro-opiomelanocortin, Proenkephalin,
            Prodynorphin, Proinsulin and Proluteinizing-hormone-releasing
            hormone. Unlike Prohormone convertase 1, does not cleave Prorenin
            or Prosomatostatin.
            Usually processing of Prodnyorphin occurs at a bond in which P2
            is Thr.
            Present in the regulated secretory pathway of Neuroendocrine cells,
            commonly actin co-opelatively with Prohormone convertase 1.
            Belongs to peptidase family S8.
GENES       CEL: C51E3.7b
            MMU: 97512(Pcsk2)
            HSA: 5126(PCSK2)
DISEASE     MIM: 162151  Proprotein convertase subtilisin/kexin type 2
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.94
            ExPASy - ENZYME nomenclature database: 3.4.21.94
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.94
            BRENDA, the Enzyme Database: 3.4.21.94
///
ENTRY       EC 3.4.21.95
NAME        Snake venom factor V activator
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Fully activates human clotting factor V by a single cleavage
            at the Trp-Tyr-Leu-Arg1545-|-Ser-Asn-Asn-Gly bond. Cattle,
            but not rabbit, factor V is cleaved, and no other proteins of
            the clotting system are attacked. Esterase activity is observed on
            Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on
            Phe-pipecolyl-Arg-NHPhNO2
INHIBITOR   Diisopropyl fluorophosphate
COMMENT     Known from venom of Vipera russelli. Inhibited by diisopropyl
            fluorophosphate, unlike the metallopeptidase russellysin
            (EC 3.4.24.58) that is specific for factor X.
            In peptidase family S1 (trypsin family).
MOTIF       PS: PS00134  [LIVM]-[ST]-A-[STAG]-H-C
            PS: PS00135  [DNSTAGC]-[GSTAPIMVQH]-x(2)-G-[DE]-S-G-[GS]-[SAPHV]-
                         [LIVMFYWH]-[LIVMFYSTANQH]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.95
            ExPASy - ENZYME nomenclature database: 3.4.21.95
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.95
///
ENTRY       EC 3.4.21.96
NAME        Lactocepin
            CEP
            Extracellular lactococcal proteinase
            Lactococcal cell wall-associated proteinase
            Lactococcal cell envelope-associated proteinase
            Lactococcal proteinase
            PrtP
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Serine endopeptidases
REACTION    Endopeptidase activity with very broad specificity, although some
            subsite preferences have been noted, e.g. large hydrophobic
            residues in the P1 and P4 positions, and Pro in the P2 position.
            Best known for its action on caseins, although it has been shown to
            hydrolyse haemoglobin and oxidised insulin B chain
COMMENT     Associated with the cell envelope of Lactococcus lactis and
            attached via a C-terminal membrane anchor sequence. Responsible for
            the hydrolysis of casein in milk and the provision of peptides
            essential to cell growth. Important in cheese making and the
            production of lactic casein, being required for rapid growth to
            high cell densities with concomitant production of adequate levels
            of lactic acid. Specificity differences between lactocepins from
            different starter strains may be partly responsible for imparting
            different flavour qualities to cheese. In peptidase family S8
            (subtilisin family).
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VIC]-[STAGC]-[GS]-x-[LIVMA]-[STAGCLV]-
                         [SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
            PS: PS00343  L-P-x-T-G-[STGAVDE]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.21.96
            ExPASy - ENZYME nomenclature database: 3.4.21.96
            WIT (What Is There) Metabolic Reconstruction: 3.4.21.96
///
ENTRY       EC 3.4.22.1
NAME        Cathepsin B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds.
            Preferentially cleaves -Arg-Arg+ bonds in small molecule
            substrates (thus differing from catheprin L).  In addition to
            being an endopeptidase, shows peptidyl-dipeptidase activity,
            liberating C-terminal dipeptides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     An intracellular (lysosomal) enzyme.
GENES       DME: CG10992
            MMU: 88561(Ctsb)
            HSA: 1508(CTSB)
DISEASE     MIM: 116810  Cathepsin B
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1PBH  1CPJ  1CSB  1CTE  1HUC  1MIR  3PBH  1QDQ  1THE  2PBH  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.1
            ExPASy - ENZYME nomenclature database: 3.4.22.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.1
            BRENDA, the Enzyme Database: 3.4.22.1
            SCOP (Structural Classification of Proteins): 3.4.22.1
///
ENTRY       EC 3.4.22.2
NAME        Papain
            Papaya peptidase I
            Calotropin
            Phytolacin
            Mexicanain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From latex of the papaya (Carica papaya).  Formerly EC 3.4.4.10.
            Many other plants contain cysteine endopeptidases, all of which
            seem to be homologues of papain, often with similar specificity.
            Examples not listed separately here are calotropin from the madar
            plant (Calotropis gigantea), phytolacin from the pokeweed
            (Phytolacca americana) and mexicanain from Pileus mexicanus
            (formerly EC 3.4.99.14).
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1CVZ  4PAD  2PAD  9PAP  6PAD  5PAD  1EFF  1STF  1PPD  1POP  
                 1PIP  1PAD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.2
            ExPASy - ENZYME nomenclature database: 3.4.22.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.2
            BRENDA, the Enzyme Database: 3.4.22.2
            SCOP (Structural Classification of Proteins): 3.4.22.2
///
ENTRY       EC 3.4.22.3
NAME        Ficain
            Ficin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     The major proteolytic component of the latex of fig, Ficus
            glabrata. Cysteine endopeptidases with similar properties are
            present in other members of the large genus Ficus. Formerly
            EC 3.4.4.12.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.3
            ExPASy - ENZYME nomenclature database: 3.4.22.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.3
            BRENDA, the Enzyme Database: 3.4.22.3
///
ENTRY       EC 3.4.22.4
NAME        Transferred to EC 3.4.22.32 and 3.4.22.33
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.22.32 - Stem bromelain, and
            EC 3.4.22.33 - Fruit bromelain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.4
            ExPASy - ENZYME nomenclature database: 3.4.22.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.4
///
ENTRY       EC 3.4.22.5
NAME        Transferred to EC 3.4.22.33
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.22.33 - Fruit bromelain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.5
            ExPASy - ENZYME nomenclature database: 3.4.22.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.5
///
ENTRY       EC 3.4.22.6
NAME        Chymopapain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     The major endopeptidase of papaya (Carica papaya) latex.  It has
            multiple chromatographic forms.  Formerly EC 3.4.4.11.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1PCI  1YAL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.6
            ExPASy - ENZYME nomenclature database: 3.4.22.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.6
            BRENDA, the Enzyme Database: 3.4.22.6
            SCOP (Structural Classification of Proteins): 3.4.22.6
///
ENTRY       EC 3.4.22.7
NAME        Asclepain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position. Does not accept Val at P1'.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.7
            ExPASy - ENZYME nomenclature database: 3.4.22.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.7
            BRENDA, the Enzyme Database: 3.4.22.7
///
ENTRY       EC 3.4.22.8
NAME        Clostripain
            Clostridiopeptidase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Preferential cleavage: Arg-|-, including Arg-|-Pro, but not Lys-
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Calcium
INHIBITOR   N2-Acylated Arg-CH2Cl
            N2-Acylated Lys-CH2Cl
            EDTA
COMMENT     From the bacterium Clostridium histolyticum.  It requires Ca2+
            ions and is inhibited by EDTA.  Not a homologue of papain.
            Formerly EC 3.4.4.20.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.8
            ExPASy - ENZYME nomenclature database: 3.4.22.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.8
            BRENDA, the Enzyme Database: 3.4.22.8
///
ENTRY       EC 3.4.22.9
NAME        Transferred to EC 3.4.21.48
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.21.48 - Cerevisin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.9
            ExPASy - ENZYME nomenclature database: 3.4.22.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.9
///
ENTRY       EC 3.4.22.10
NAME        Streptopain
            Streptococcus peptidase A
            Streptococcal cysteine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Preferential cleavage with hydrophobic residues at P2, P1 and P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Formed the bacterium, group A Streptococcus.  Apparently not a
            homologue of papain.  Formed from the proenzyme by limited
            proteolysis.  Formerly EC 3.4.4.18.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.10
            ExPASy - ENZYME nomenclature database: 3.4.22.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.10
            BRENDA, the Enzyme Database: 3.4.22.10
///
ENTRY       EC 3.4.22.11
NAME        Transferred to EC 3.4.24.56
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.24.56 - Insulinase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.11
            ExPASy - ENZYME nomenclature database: 3.4.22.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.11
///
ENTRY       EC 3.4.22.12
NAME        Transferred to EC 3.4.19.9
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.19.9 - gamma-Glu-X carboxypeptidase.
STRUCTURES  PDB: 1FO6  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.12
            ExPASy - ENZYME nomenclature database: 3.4.22.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.12
///
ENTRY       EC 3.4.22.13
NAME        Deleted entry
            Staphylococcal cysteine proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.13
            ExPASy - ENZYME nomenclature database: 3.4.22.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.13
///
ENTRY       EC 3.4.22.14
NAME        Actinidain
            Actinidin
            Actinidia anionic protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the kiwi fruit or Chinese gooseberry (Actinidia chinensis).
GENES       MMU: 88564(Ctsl)
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1FTV  1AEC  1FOG  1F3Q  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.14
            ExPASy - ENZYME nomenclature database: 3.4.22.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.14
            BRENDA, the Enzyme Database: 3.4.22.14
            SCOP (Structural Classification of Proteins): 3.4.22.14
///
ENTRY       EC 3.4.22.15
NAME        Cathepsin L
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            with preference for a residue bearing a large hydrophobic
            sidechain at the P2 position.  Does not accept Val at P1'.
            As compared to cathepsin B, cathepsin L exhibits higher activity
            towards protein substrates, but has little activity on
            Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Leupeptin
            Z-Phe-Phe-CHN2
            E-64
COMMENT     A lysosomal enzyme that is readily inhibited by the deazomethane
            inhibitor Z-Phe-Phe-CHN2 or the epoxide inhibitor E-64.
GENES       CEL: T03E6.7
            DME: CG6692(Cp1)
            MMU: 88564(Ctsl)
            HSA: 1514(CTSL)
DISEASE     MIM: 116880  Cathepsin L
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1BMU  1ICF  1CS8  1CJL  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.15
            ExPASy - ENZYME nomenclature database: 3.4.22.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.15
            BRENDA, the Enzyme Database: 3.4.22.15
            SCOP (Structural Classification of Proteins): 3.4.22.15
///
ENTRY       EC 3.4.22.16
NAME        Cathepsin H
            Cathepsin B3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins, acting as an aminopeptidase (notably,
            cleaving Arg+ bonds) as well as an endopeptidase
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Peptide
COMMENT     Present in lysosomes of most mammalian cells.
GENES       MMU: 107285(Ctsh)
            HSA: 1512(CTSH)
DISEASE     MIM: 116820  Cathepsin H
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 8PCH  1BZN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.16
            ExPASy - ENZYME nomenclature database: 3.4.22.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.16
            BRENDA, the Enzyme Database: 3.4.22.16
            SCOP (Structural Classification of Proteins): 3.4.22.16
///
ENTRY       EC 3.4.22.17
NAME        Calpain
            Ca2+-activated neutral protease (CANP)
            mu-calpain
            calpain I
            muCANP
            m-calpain
            calpain II
            mCANP
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Preferential cleavege: Tyr+, Met+, or Arg+ with Leu or Val as the
            P2 residue
SUBSTRATE   Protein
            Peptide
            Troponin I
            Tropomyosin
            C-Protein
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Calcium
COMMENT     An intracellular, non-lysosomal enzyme.  There are two main types
            of calpain: one with high Ca2+ sensitivity in the micromolar
            range, called mu-calpain, calpain I or muCANP, and the other with
            low Ca2+ sensitivity in the millimolar range, called m-calpain,
            calpain II or mCANP.  Forms of intermediate Ca2+ sensitivity also
            exist.  A component of lens neutral proteinase (formerly
            EC 3.4.24.5).
GENES       DME: CG7563(CalpA) CG8107(CalpB)
            MMU: 107437(Capn3)
            HSA: 10753(CAPN9) 11131(CAPN11) 11132(CAPN10) 23473(CAPN7)
                 823(CAPN1) 824(CAPN2) 825(CAPN3) 826(CAPN4) 827(CAPN6)
                 831(CAST)
DISEASE     MIM: 114220  Calpain, large polypeptide L1
            MIM: 114230  Calpain, large polypeptide L2
            MIM: 114240  Calpain, large polypeptide L3
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1DKV  1DF0  1ALW  1ALV  1AJ5  1DVI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.17
            ExPASy - ENZYME nomenclature database: 3.4.22.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.17
            BRENDA, the Enzyme Database: 3.4.22.17
            SCOP (Structural Classification of Proteins): 3.4.22.17
///
ENTRY       EC 3.4.22.18
NAME        Transferred to EC 3.4.21.26
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.21.26 - Prolyl
            oligopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.18
            ExPASy - ENZYME nomenclature database: 3.4.22.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.18
            BRENDA, the Enzyme Database: 3.4.22.18
///
ENTRY       EC 3.4.22.19
NAME        Transferred to EC 3.4.24.15
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.24.15 - Thimet
            oligopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.19
            ExPASy - ENZYME nomenclature database: 3.4.22.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.19
///
ENTRY       EC 3.4.22.20
NAME        Deleted entry
            Dinorphin-converting enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.20
            ExPASy - ENZYME nomenclature database: 3.4.22.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.20
///
ENTRY       EC 3.4.22.21
NAME        Transferred to EC 3.4.99.46
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.99.46 -
            Multicatalytic endopeptidase complex.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.21
            ExPASy - ENZYME nomenclature database: 3.4.22.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.21
///
ENTRY       EC 3.4.22.22
NAME        Transferred to EC 3.4.24.37
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now EC 3.4.24.37 - Saccharolysin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.22
            ExPASy - ENZYME nomenclature database: 3.4.22.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.22
///
ENTRY       EC 3.4.22.23
NAME        Transferred to EC 3.4.21.61
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.21.61 - Kexin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.23
            ExPASy - ENZYME nomenclature database: 3.4.22.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.23
///
ENTRY       EC 3.4.22.24
NAME        Cathepsin T
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Interconversion of the three forms of tyrosine aminotransferase,
            EC 2.6.1.5.
SUBSTRATE   [Tyrosine aminotransferase]
            H2O
PRODUCT     Peptide
COMMENT     Degrades azocasein and denatured hemoglobin; the only native
            protein on which it has been shown to act is tyrosine
            aminotransferase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.24
            ExPASy - ENZYME nomenclature database: 3.4.22.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.24
            BRENDA, the Enzyme Database: 3.4.22.24
///
ENTRY       EC 3.4.22.25
NAME        Glycyl endopeptidase
            Papaya peptidase B
            Papaya proteinase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Preferential cleavage: Gly+, in proteins and small molecule
            substrates.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the papaya plant, Carica papaya. Not inhibited by chicken
            cystatin, unlike most other homologues of papain.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1GEC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.25
            ExPASy - ENZYME nomenclature database: 3.4.22.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.25
            BRENDA, the Enzyme Database: 3.4.22.25
            SCOP (Structural Classification of Proteins): 3.4.22.25
///
ENTRY       EC 3.4.22.26
NAME        Cancer procoagulant
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Specific cleavage of Arg-|-Ile bond in Factor X to form Factor Xa.
SUBSTRATE   Factor X
            H2O
PRODUCT     Factor Xa
COMMENT     Apparently produced only by malignant and fetal cells.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.26
            ExPASy - ENZYME nomenclature database: 3.4.22.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.26
            BRENDA, the Enzyme Database: 3.4.22.26
///
ENTRY       EC 3.4.22.27
NAME        Cathepsin S
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Similar to cathepsin L, but with much less activity on
            Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-
            compound.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A lysosomal cysteine endopeptidase that is unusual amongst such
            enzymes for its stability to neutral pH.
GENES       MMU: 107341(Ctss)
            HSA: 1520(CTSS)
DISEASE     MIM: 116845  Cathepsin S
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1BXF  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.27
            ExPASy - ENZYME nomenclature database: 3.4.22.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.27
            BRENDA, the Enzyme Database: 3.4.22.27
            SCOP (Structural Classification of Proteins): 3.4.22.27
///
ENTRY       EC 3.4.22.28
NAME        Picornain 3C
            Picornavirus endopeptidase 3C
            Poliovirus protease 3C
            Rhinovirus protease 3C
            Foot-and-mouth protease 3C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein.
            In other picornavirus reactions Glu may be substituted for Gln,
            and Ser or Thr for Gly.
SUBSTRATE   Poliovirus polyprotein
            H2O
PRODUCT     Protein
COMMENT     From entero-, rhino-, aphto- and cardioviruses. Larger than the
            homologous virus picornain 2A, but not a homologue of papain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.28
            ExPASy - ENZYME nomenclature database: 3.4.22.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.28
            BRENDA, the Enzyme Database: 3.4.22.28
///
ENTRY       EC 3.4.22.29
NAME        Picornain 2A
            Picornavirus endopeptidase 2A
            Poliovirus protease 2A
            Rhinovirus protease 2A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
SUBSTRATE   Picornavirus polyprotein
            H2O
PRODUCT     Protein
COMMENT     From entero-, rhino-, aphto- and cardioviruses. Smaller than the
            homologous picornain 3C, but not a homologue of papain.
STRUCTURES  PDB: 2HRV  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.29
            ExPASy - ENZYME nomenclature database: 3.4.22.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.29
            BRENDA, the Enzyme Database: 3.4.22.29
            SCOP (Structural Classification of Proteins): 3.4.22.29
///
ENTRY       EC 3.4.22.30
NAME        Caricain
            Papaya peptidase A
            Papaya peptidase II
            Papaya proteinase Q
            Papaya proteinase III
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds,
            similar to those of papain and chymopapain
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the papaya plant, Carica papaya.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1C7X  1EUX  1F1I  1MEG  1PPO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.30
            ExPASy - ENZYME nomenclature database: 3.4.22.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.30
            BRENDA, the Enzyme Database: 3.4.22.30
            SCOP (Structural Classification of Proteins): 3.4.22.30
///
ENTRY       EC 3.4.22.31
NAME        Ananain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds.
            Best reported small molecule substrate Bz-Phe-Val-Arg-|-NHMec, but
            broader specificity than fruit bromelain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From stem of pineapple plant, Ananas comosus. Differs from stem
            and fruit bromelains in being inhibited by chicken cystatin.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.31
            ExPASy - ENZYME nomenclature database: 3.4.22.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.31
            BRENDA, the Enzyme Database: 3.4.22.31
///
ENTRY       EC 3.4.22.32
NAME        Stem bromelain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Broad specificity for cleavage of proteins, but strong preference
            for Z-Arg-Arg-|-NHMec amongst small molecule substrates
SUBSTRATE   Protein
            Peptide
            Z-Arg-Arg-NHMec
            H2O
PRODUCT     Protein
            Peptide
            Z-Arg-Arg
            NH2Mec
COMMENT     The most abundant of the cysteine endopeptidases of the stem of
            the pineapple plant, Ananas comosus.  Distinct from the bromelain
            found in the pineapple fruit (EC 3.4.22.33).  Scarcely inhibited
            by chicken cystatin, and also very slowly inactivated by E-64.
            Formerly EC 3.4.4.24 and included in EC 3.4.22.4.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.32
            ExPASy - ENZYME nomenclature database: 3.4.22.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.32
            BRENDA, the Enzyme Database: 3.4.22.32
///
ENTRY       EC 3.4.22.33
NAME        Fruit bromelain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins with broad specificity for peptide bonds.
            Bz-Phe-Val-Arg-|-NHMec is a good synthetic substrate, but there is
            no action on Z-Arg-Arg-NHMec (cf. stem bromelain).
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the pineapple plant, Ananas comosus. Scarcely inhibited by
            chicken cystatin.  Another cysteine endopeptidase, with similar
            action on small molecule substrates, pinguinain (formerly
            EC 3.4.99.18), is obtained from the related plant, Bromelia
            pinguin, but pinguinain differs from fruit bromelain in being
            inhibited by chicken cystatin. Formerly EC 3.4.22.5 and
            included in EC 3.4.22.4.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.33
            ExPASy - ENZYME nomenclature database: 3.4.22.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.33
            BRENDA, the Enzyme Database: 3.4.22.33
///
ENTRY       EC 3.4.22.34
NAME        Legumain
            Bean endopeptidase
            Vicilin peptidohydrolase
            Phaseolin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins, such as azocasein. Preferential cleavage:
            Asn+ in small molecule substrates such as Boc-Asn-|-OPhNO2
SUBSTRATE   Protein
            Peptide
            H2O
            Boc-Asn-OPhNO2
PRODUCT     Protein
            Peptide
            Boc-Asn
            HOPhNO2
COMMENT     From germinating cotyledons of mung bean (Vigna radiata) and
            garden bean (Phaseolus vulgaris).  Thought to be involved in the
            hydrolysis of stored seed proteins.
GENES       HSA: 5641(PRSC1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.34
            ExPASy - ENZYME nomenclature database: 3.4.22.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.34
            BRENDA, the Enzyme Database: 3.4.22.34
///
ENTRY       EC 3.4.22.35
NAME        Histolysain
            Histolysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Hydrolysis of proteins, including basement membrane collagen and
            azocasein. Preferential cleavage: Arg-Arg+ in small molecule
            substrates including Z-Arg-Arg-|-NHMec.
SUBSTRATE   Protein
            Peptide
            H2O
            Collagen
            Azocasein
PRODUCT     Protein
            Peptide
COMMENT     From trotozoan, Entamoeba histolytica. A homologue of papain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.35
            ExPASy - ENZYME nomenclature database: 3.4.22.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.35
            BRENDA, the Enzyme Database: 3.4.22.35
///
ENTRY       EC 3.4.22.36
NAME        Interleukin 1-beta converting enzyme
            Interleukin 1-beta converting precursor
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Release of Interleukin 1-beta by specific cleavage at
            116-Asp-|-Ala-117 and 27-Asp-|-Gly-28 bonds in precursor.
COMMENT     Inhibited by Ac-Tyr-Val-Ala-Asp-CHN(2).
            Belongs to peptidase family C14.
GENES       MMU: 96544(Casp1)
            HSA: 834(CASP1)
DISEASE     MIM: 147678  Caspase 1, apoptosis-related cysteine protease
                         (interleukin-1, beta
MOTIF       PS: PS01121  H-x(2,4)-[SC]-x(4)-[LIVMF](2)-[ST]-H-G
            PS: PS01122  K-P-K-[LIVMF](4)-Q-A-C-[RQG]-G
STRUCTURES  PDB: 1BMQ  1IBC  1ICE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.36
            ExPASy - ENZYME nomenclature database: 3.4.22.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.36
            BRENDA, the Enzyme Database: 3.4.22.36
            SCOP (Structural Classification of Proteins): 3.4.22.36
///
ENTRY       EC 3.4.22.37
NAME        Gingipain R
            Arg-Gingipain
            Argingipain
            Gingipain 1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Cleavage of proteins, including collagens and immunoglobulins, with
            a preference for Arg in P1, and hydrophobic residues in P2 and P3.
COMMENT     Strongly activated by Glycine and stabilized by Calcium.
            Belongs to peptidase family C25.
STRUCTURES  PDB: 1CVR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.37
            ExPASy - ENZYME nomenclature database: 3.4.22.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.37
            BRENDA, the Enzyme Database: 3.4.22.37
            SCOP (Structural Classification of Proteins): 3.4.22.37
///
ENTRY       EC 3.4.22.38
NAME        Cathepsin K
            Cathepsin O
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Cysteine endopeptidases
REACTION    Potent endoprotease activity against fibrinogen at acid PH.
SUBSTRATE   Fibrinogen
COMMENT     Belongs to peptidase family C1.
GENES       DME: CG4847
            MMU: 107823(Ctsk)
            HSA: 1513(CTSK)
DISEASE     MIM: 601105  Cathepsin K
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
STRUCTURES  PDB: 1AU0  1AU2  1AU3  1AU4  1AYU  1AYV  1AYW  1BGO  1BY8  1MEM  
                 7PCK  1ATK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.22.38
            ExPASy - ENZYME nomenclature database: 3.4.22.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.22.38
            SCOP (Structural Classification of Proteins): 3.4.22.38
///
ENTRY       EC 3.4.23.1
NAME        Pepsin A
            Pepsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions.  Cleaves Phe1-|-Val, Gln4-|-His,
            Glu13-|-Ala, Ala14-|-Leu, Leu15-|-Tyr, Tyr16-|-Leu, Gly23-|-Phe,
            Phe24-|-Phe and Phe25-|-Tyr bonds in the B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Methyl 2-diazoacetamidohexonate
COMMENT     The predominant endopeptidase in the gastric juice of vertebrates,
            formed from pepsinogen A by limited proteolysis.  Human pepsin A
            occurs in five molecular forms.  Pig pepsin D is
            unphosphorylated pepsin A.  Formerly EC 3.4.4.1.
GENES       HSA: 5220(PGA3) 5221(PGA4) 5222(PGA5)
DISEASE     MIM: 169710  Pepsinogen A3
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 5PEP  1AM5  1F34  1PSA  1PSN  1PSO  3PEP  4PEP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.1
            ExPASy - ENZYME nomenclature database: 3.4.23.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.1
            BRENDA, the Enzyme Database: 3.4.23.1
            SCOP (Structural Classification of Proteins): 3.4.23.1
///
ENTRY       EC 3.4.23.2
NAME        Pepsin B
            Parapepsin I
            Pig gelatinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Degradation of gelatin; little activity on hemoglobin.
            Specificity on B chain of insulin more restricted than that of
            pepsin A; does not cleave at Phe1-Val, Gln4-His or Gly23-Phe
SUBSTRATE   Gelatine
            H2O
            N-Acetyl-L-phenylalanyl-L-diiodotyrosine
PRODUCT     Oligopeptide
            N-Acetyl-L-phenylalanine
            L-Diiodotyrosine
COMMENT     Formed from pig pepsinogen B.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.2
            ExPASy - ENZYME nomenclature database: 3.4.23.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.2
            BRENDA, the Enzyme Database: 3.4.23.2
///
ENTRY       EC 3.4.23.3
NAME        Gastricsin
            Pepsin C
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    More restricted specificity than pepsin A, but shows preferential
            cleavage at Tyr+ bonds.  High activity on hemoglobin
SUBSTRATE   Protein
            Peptide
            Hemoglobin
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Formed from progastricsin, apparently in the gastric juice of most
            vertebrates.  In addition to the fundus, progastricsin is also
            secreted in antrum and proximal duodenum.  Seminal plasma contains
            a zymogen that is immunologically identical with progastricsin.
            Formerly EC 3.4.4.22.
GENES       HSA: 5225(PGC)
DISEASE     MIM: 169740  Preprogastricsin
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1AVF  1HTR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.3
            ExPASy - ENZYME nomenclature database: 3.4.23.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.3
            BRENDA, the Enzyme Database: 3.4.23.3
            SCOP (Structural Classification of Proteins): 3.4.23.3
///
ENTRY       EC 3.4.23.4
NAME        Chymosin
            Rennin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions.  Cleaves Phe1-|-Val, Gln4-|-His,
            Glu13-|-Ala, Ala14-|-Leu, Leu15-|-Tyr, Tyr16-|-Leu, Gly23-|-Phe,
            Phe24-|-Phe and Phe25-|-Tyr bonds in the B chain of insulin.
            Clots milk by cleavage of a single Ser-Phe105-|-Met-Ala bond in
            kappa-chain of casein
REACTION    Cleaves a single bond in casein k
SUBSTRATE   Protein
            Peptide
            Casein K
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Neonatal gastric proteinase with high milk clotting and weak
            general proteolytic activity. Found among mammals with pastnatal
            uptake of imminoglobulins. Formed from prochymosin by a limited
            proteolysis that removes a propart of 42 amino acid residues from
            the N-terminal of the zymogen.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1CMS  1CZI  3CMS  4CMS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.4
            ExPASy - ENZYME nomenclature database: 3.4.23.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.4
            BRENDA, the Enzyme Database: 3.4.23.4
            SCOP (Structural Classification of Proteins): 3.4.23.4
///
ENTRY       EC 3.4.23.5
NAME        Cathepsin D
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Specificity similar to, but narrower than, that of pepsin A
            (Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions.  Cleaves Phe1-|-Val, Gln4-|-His,
            Glu13-|-Ala, Ala14-|-Leu, Leu15-|-Tyr, Tyr16-|-Leu, Gly23-|-Phe,
            Phe24-|-Phe and Phe25-|-Tyr bonds in the B chain of insulin.)
            Does not cleave the Gln4-His bond in B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Methyl 2-diazoacetamidohexonate
COMMENT     Occurs intracellularly, in lysosomes.  A zymogen form is known.
            Formerly EC 3.4.4.23.
GENES       DME: CG1548
            MMU: 88562(Ctsd)
            HSA: 1509(CTSD)
DISEASE     MIM: 116840  Cathepsin D (lysosomal aspartyl protease)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1LYA  1LYB  1LYW  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.5
            ExPASy - ENZYME nomenclature database: 3.4.23.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.5
            BRENDA, the Enzyme Database: 3.4.23.5
            SCOP (Structural Classification of Proteins): 3.4.23.5
///
ENTRY       EC 3.4.23.6
NAME        Deleted entry
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Deleted entry. See EC 3.4.23.18 - Aspergillopepsin I;
            EC 3.4.23.19 - Aspergillopepsin II;
            EC 3.4.23.20 - Penicillopepsin; EC 3.4.23.21 - Rhizopepsin;
            EC 3.4.23.22 - Endothiapepsin; EC 3.4.23.23 - Mucorpepsin;
            EC 3.4.23.24 - Candidapepsin; EC 3.4.23.25 - Saccharopepsin;
            EC 3.4.23.26 - Rhodotorulapepsin; EC 3.4.23.27 - Physaropepsin;
            EC 3.4.23.28 - Acrocylindropepsin; EC 3.4.23.30 - Pycnoporopepsin.
STRUCTURES  PDB: 1ER8  2APR  2ER0  2ER6  2ER7  3APR  3ER3  3ER5  4APR  4ER1  
                 4ER2  4ER4  5APR  5ER1  5ER2  2ER9  6APR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.6
            ExPASy - ENZYME nomenclature database: 3.4.23.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.6
            SCOP (Structural Classification of Proteins): 3.4.23.6
///
ENTRY       EC 3.4.23.7
NAME        Transferred to EC 3.4.23.20
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Transferred entry. Now EC 3.4.23.20 - Penicillopepsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.7
            ExPASy - ENZYME nomenclature database: 3.4.23.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.7
///
ENTRY       EC 3.4.23.8
NAME        Transferred to EC 3.4.23.25
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Transferred entry. Now EC 3.4.23.25 - Saccharopepsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.8
            ExPASy - ENZYME nomenclature database: 3.4.23.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.8
///
ENTRY       EC 3.4.23.9
NAME        Transferred to EC 3.4.23.21
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Transferred entry. Now EC 3.4.23.21 - Rhizopepsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.9
            ExPASy - ENZYME nomenclature database: 3.4.23.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.9
///
ENTRY       EC 3.4.23.10
NAME        Transferred entry EC 3.4.23.22
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Transferred entry. Now EC 3.4.23.22 - Endothiapepsin.
STRUCTURES  PDB: 4APE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.10
            ExPASy - ENZYME nomenclature database: 3.4.23.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.10
            SCOP (Structural Classification of Proteins): 3.4.23.10
///
ENTRY       EC 3.4.23.11
NAME        Deleted entry
            Thyroid aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.11
            ExPASy - ENZYME nomenclature database: 3.4.23.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.11
///
ENTRY       EC 3.4.23.12
NAME        Nepenthesin
            Nepenthes aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Similar to pepsin, but also cleaves on either side of Asp and at
            Lys-|-Arg
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the insectivorus plants nepenthes sp. (secretions) and
            Drosera peltata (group-up leaves).  Formerly ec 3.4.99.4.
            Aspartic endopeptidases are probably present in many other plants,
            Including Latus (formerly EC 3.4.23.13) and Sorghum (formerly
            EC 3.4.23.14)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.12
            ExPASy - ENZYME nomenclature database: 3.4.23.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.12
            BRENDA, the Enzyme Database: 3.4.23.12
///
ENTRY       EC 3.4.23.13
NAME        Deleted entry
            Lotus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.13
            ExPASy - ENZYME nomenclature database: 3.4.23.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.13
///
ENTRY       EC 3.4.23.14
NAME        Deleted entry
            Sorghum aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
COMMENT     Deleted entry
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.14
            ExPASy - ENZYME nomenclature database: 3.4.23.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.14
///
ENTRY       EC 3.4.23.15
NAME        Renin
            Angiotensin-forming enzyme
            Angioteninogenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Cleaves of Leu+ bond in angiotensinogen to generate angiotensin I
SUBSTRATE   Angiotensinogen
            H2O
PRODUCT     Angiotensin I
COMMENT     Formed from prorenin in plasma and kidney.  Formerly EC 3.4.99.19.
GENES       MMU: 97898(Ren1) 97899(Ren2)
            HSA: 5972(REN)
DISEASE     MIM: 179820  Renin
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1SMR  2REN  1BBS  1RNE  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.15
            ExPASy - ENZYME nomenclature database: 3.4.23.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.15
            BRENDA, the Enzyme Database: 3.4.23.15
            SCOP (Structural Classification of Proteins): 3.4.23.15
///
ENTRY       EC 3.4.23.16
NAME        Retropepsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Specific for a P1 residue that is hydrophobic, and P1' variable,
            but often Pro.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Active enzyme is a dimer of identical 11kD subunits. Present in
            human immunodeficiency virus (HIV-1), and various leukemia and
            other viruses.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1BWB  1D4K  1D4L  1D4S  1D4Y  1DAZ  1DMP  1BV7  1EBK  1F7A  
                 1FEJ  1FF0  1FFF  1FFI  1FG6  1FG8  1FGC  1FIV  1FMB  1BWA  
                 1FQX  1G35  1G6L  1HPO  1HVH  1HWR  1HXB  1HXW  1JLD  1BDR  
                 1BDQ  1MET  1MEU  1MTR  1ODW  1ODX  1ODY  1PRO  1QBR  1QBS  
                 1G2K  1BVG  1QBT  1TCX  1UPJ  1VIJ  1VIK  1YTG  1YTH  1YTI  
                 1YTJ  1BDL  2FIV  2FMB  2UPJ  3AID  3FIV  3TLH  3UPJ  4FIV  
                 4UPJ  5FIV  5UPJ  6FIV  6UPJ  7UPJ  1B6P  1B6O  1B6N  1B6M  
                 1B6L  1B6K  1B6J  1B11  1AZ5  1AXA  1AJX  1AJV  1AID  1A94  
                 1A8K  1A8G  1A30  1BVE  1QBU  1BV9  1TCW  1MER  1MES  1DW6  
                 2AID  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.16
            ExPASy - ENZYME nomenclature database: 3.4.23.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.16
            BRENDA, the Enzyme Database: 3.4.23.16
            SCOP (Structural Classification of Proteins): 3.4.23.16
///
ENTRY       EC 3.4.23.17
NAME        Pro-opiomelanocortin converting enzyme
            Prohormone converting enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Cleavage at paired besic residues in certain prohormones, either
            between tham, or on the carboxyl side.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A 70 kDa membrane-bound enzyme isolated from cattle pituitary
            secretory vesicle. Formerly EC 3.4.99.38.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.17
            ExPASy - ENZYME nomenclature database: 3.4.23.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.17
            BRENDA, the Enzyme Database: 3.4.23.17
///
ENTRY       EC 3.4.23.18
NAME        Aspergillopepsin I
            Awamorin
            Aspergillopepsin A
            Aspergillopepsin F
            Proteinase B
            Proctase B
            Trypsinogen kinase
            Aspergillopeptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of rpteoins with broad specificity.  Generally favours
            hydrophobic residues in P1 and P1', but also accepts Lys in P1,
            which leads to activation of trypsinogen.  Does not clot milk
SUBSTRATE   Protein
            Peptide
            Trypsinogen
            H2O
PRODUCT     Protein
            Peptide
            Trypsin
COMMENT     Found in a variety of Aspergillus species (imperfect fungi):
            Aspergillus awamori (awamorin, aspergillopepsin A),
            A. foetidus (aspergillopepsin F), A. fumigatus, A. kawachii,
            A. niger (proteinase B, proctase B), A. oryzae (trypsinogen
            kinase), A. saitoi (aspergillopeptidase A), and A. sojae.
            Formerly included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1IBQ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.18
            ExPASy - ENZYME nomenclature database: 3.4.23.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.18
            BRENDA, the Enzyme Database: 3.4.23.18
///
ENTRY       EC 3.4.23.19
NAME        Aspergillopepsin II
            Proteinase A
            Proctase A
            Aspergillus niger var. macrosporus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preverential cleavage in B chain of insulin: Asn3-|-Gln,
            Gly13-|-Ala, Tyr26-|-Thr.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Isolated from Aspergillus niger var. macrsprus, distinct from
            proteinase B (see aspergillopepsin I) in specificity and
            insensitivity to pepstatin, Formerly included in EC 3.4.23.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.19
            ExPASy - ENZYME nomenclature database: 3.4.23.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.19
            BRENDA, the Enzyme Database: 3.4.23.19
///
ENTRY       EC 3.4.23.20
NAME        Penicillopepsin
            Peptidase A
            Penicillium janthinellum aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad specificity similar to that of
            pepsin A, preferring hydrophobic residues at P1 and P1', but also
            cleaving Gly20-|-Glu in the B chain of insulin.  Clots milk, and
            activates trypsinogen
SUBSTRATE   Protein
            Peptide
            Casein
            Trypsinogen
            H2O
PRODUCT     Protein
            Peptide
            Trypsin
COMMENT     From the imperfect fungus Penicillium janthinellum.  Homologue of
            pepsin A, and similar in structure. Closely related enzymes have
            been isolated from P. roqueforti and P. duponti.
            Formerly EC 3.4.23.7, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1BXQ  2WEA  2WEB  3APP  2WED  2WEC  1APT  1APU  1APV  1APW  
                 1BXO  1PPK  1PPL  1PPM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.20
            ExPASy - ENZYME nomenclature database: 3.4.23.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.20
            BRENDA, the Enzyme Database: 3.4.23.20
            SCOP (Structural Classification of Proteins): 3.4.23.20
///
ENTRY       EC 3.4.23.21
NAME        Rhizopuspepsin
            Rhizopus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad specificity similar to that of
            pepsin A, preferring hydrophobic residues at P1 and P1'.  Clots
            milk and activates trypsinogen.  Does not cleave Gln4-His, but
            does cleave His10-|-Leu and Val12-|-Glu in B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the zygomycete fungus Rhizopus chinensis.  Homologue of
            pepsin A.  A similar endopeptidase is found in R. niveus.
            Formerly EC 3.4.23.9, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.21
            ExPASy - ENZYME nomenclature database: 3.4.23.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.21
            BRENDA, the Enzyme Database: 3.4.23.21
///
ENTRY       EC 3.4.23.22
NAME        Endothiapepsin
            Endothia aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with specificity similar to that of pepsin
            A; prefers hydrophobic residues at P1 and P1', but does not cleave
            Ala14-Leu in the B chain of insulin or Z-Glu-Tyr.  Clots milk
SUBSTRATE   Protein
            Peptide
            Casein
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the ascomycete Endothia parasitica.  A homologue of pepsin A.
            Formerly EC 3.4.23.10, and included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1EPN  1ENT  1EPR  1EED  1EPL  1EPM  1EPQ  1EPP  1EPO  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.22
            ExPASy - ENZYME nomenclature database: 3.4.23.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.22
            BRENDA, the Enzyme Database: 3.4.23.22
            SCOP (Structural Classification of Proteins): 3.4.23.22
///
ENTRY       EC 3.4.23.23
NAME        Mucorpepsin
            Mucor rennin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins, favouring hydrophobic residues at P1 and
            P1'.  Clots milk.  Does not accept Lys at P1, and hence does not
            activate trypsinogen
SUBSTRATE   Protein
            Peptide
            Casein
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Isolated from the zygomycete fungi Mucor pusillus and M. miehei.
            The two species variants show 83% sequence identity and are
            immunologically crossreactive.  Formerly included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1E82  1E5O  2RMP  2ASI  1E81  1MPP  1E80  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.23
            ExPASy - ENZYME nomenclature database: 3.4.23.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.23
            BRENDA, the Enzyme Database: 3.4.23.23
            SCOP (Structural Classification of Proteins): 3.4.23.23
///
ENTRY       EC 3.4.23.24
NAME        Candidapepsin
            Candida albicans aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage at the carboxyl of hydrophobic amino acids,
            but fails to cleave Leu15-Tyr, Tyr16-Leu and Phe24-Phe of insulin
            B chain.  Activates trypsinogen, and degrades keratin
SUBSTRATE   Protein
            Peptide
            Trypsinogen
            Keratin
            H2O
PRODUCT     Protein
            Peptide
            Trypsin
INHIBITOR   Pepstatin
COMMENT     This endopeptidase from the imperfect yeast Candida albicans is
            inhibited by pepstatin, but not by methyl 2-diazoacetamido-
            hexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane.  Formerly
            included in EC 3.4.23.6.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1J71  1ZAP  1EAG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.24
            ExPASy - ENZYME nomenclature database: 3.4.23.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.24
            BRENDA, the Enzyme Database: 3.4.23.24
            SCOP (Structural Classification of Proteins): 3.4.23.24
///
ENTRY       EC 3.4.23.25
NAME        Saccharopepsin
            Yeast endopeptidase A
            Saccharomyces aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad sprcificity for peptide bonds.
            Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not
            act on esters of Tyr or Arg
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Located in the vacuole of the baker's yeast (Saccharomyces
            cerevisiae) cell.  A homologue of pepsin A.  Formerly EC 3.4.23.8,
            and included in EC 3.4.23.6.
GENES       SCE: YPL154C(PEP4)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1FQ7  1FQ8  2JXR  1G0V  1FQ6  1FQ5  1FQ4  1DPJ  1DP5  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.25
            ExPASy - ENZYME nomenclature database: 3.4.23.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.25
            BRENDA, the Enzyme Database: 3.4.23.25
            SCOP (Structural Classification of Proteins): 3.4.23.25
///
ENTRY       EC 3.4.23.26
NAME        Rhodotorulapepsin
            Rhodotorula aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions.  Cleaves Z-Lys-|-Ala-Ala-Ala and activates
            trypsinogen.
SUBSTRATE   Protein
            Peptide
            H2O
            Trypsinogen
PRODUCT     Protein
            Peptide
            Trypsin
COMMENT     From the imperfect yeast Rhodotorula glutinis. Formerly included
            in EC 3.4.23.6.  Somewhat similar enzymes have been isolated from
            the imperfect yeast-like organism Cladosporium sp. and the
            imperfect fungus Paecilomyces varioti.
            Formerly EC 3.4.99.15.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.26
            ExPASy - ENZYME nomenclature database: 3.4.23.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.26
            BRENDA, the Enzyme Database: 3.4.23.26
///
ENTRY       EC 3.4.23.27
NAME        Physaropepsin
            Physarum aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Milk clotting activity.  Preferential cleavage of Gly8-|-Ser in B
            chain of insulin most rapidly, followed by Leu11-|-Val,
            Cys(SO3H)19-|-Gly and Phe24-|-Phe. No action on Ac-Phe-Tyr(I)2
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Methyl 2-diazoacetamidohexanoate
COMMENT     From the slime mould Physarum polycephalum.  Is not inhibited by
            pepstatin, but is blocked by methyl 2-diazoacetamidohexanoate.
            Closely similar enzymes are found in Dictyostelium discoideum
            and P. Flavicomum.  Formerly included in EC 3.4.23.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.27
            ExPASy - ENZYME nomenclature database: 3.4.23.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.27
            BRENDA, the Enzyme Database: 3.4.23.27
///
ENTRY       EC 3.4.23.28
NAME        Acrocylindropepsin
            Acrocylindrium proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preference for hydrophobic residues at P1 and P1'. Action on the
            B chain of insulin is generally similar to that of pepsin A, but
            it also cleaves Leu6-|-Cys(SO3H), Glu21-|-Arg and Asn3-|-Gln,
            although not Gln3-His.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the imperfect fungus Acrocylindrium sp.  Has a very low pH
            optimum on casein of 2.0.  Formerly EC 3.4.99.1 and included in
            EC 3.4.23.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.28
            ExPASy - ENZYME nomenclature database: 3.4.23.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.28
            BRENDA, the Enzyme Database: 3.4.23.28
///
ENTRY       EC 3.4.23.29
NAME        Polyporopepsin
            Polyporus aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Milk clotting activity, broad specificity, but fails to cleave
            Leu15-Tyr or Tyr16-Leu of insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the basidiomycete Polyporus tulipiferae (formerly Irpex
            lacteus).  A homologue of pepsin A.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.29
            ExPASy - ENZYME nomenclature database: 3.4.23.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.29
            BRENDA, the Enzyme Database: 3.4.23.29
///
ENTRY       EC 3.4.23.30
NAME        Pycnoporopepsin
            Proteinase Ia
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions. Cleaving only three bonds in
            the B chain of insulin: Ala14-|-Leu, Tyr16-|-Leu, and Phe24-|-Phe
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     From the basidiomycete Pycnoporus sanguineus, formerly known as
            P. coccineus and Trametes sanguinea.  Formerly included in
            EC 3.4.23.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.30
            ExPASy - ENZYME nomenclature database: 3.4.23.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.30
            BRENDA, the Enzyme Database: 3.4.23.30
///
ENTRY       EC 3.4.23.31
NAME        Scytalidopepsin A
            Scytalidium aspartic proteinase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Preferential cleavage: hydrophobic, preferably aromatic, residues
            in P1 and P1' positions. Cleaves Cys(SO3H)7-|-Gly and Leu17-|-Val
            in the B chain of insulin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Isolated from the imperfect fungus Scytalidium lignicolum.  Not
            inhibited by pepstatin-Ac, methyl 2-diazoacetamidohexanoate or
            1,2-epoxy-3-(p-nitrophenyl)propane.  A related enzyme from the
            same organism, proteinase C, is also insensitive to these
            inhibitors and has Mr = 406 kDa.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.31
            ExPASy - ENZYME nomenclature database: 3.4.23.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.31
            BRENDA, the Enzyme Database: 3.4.23.31
///
ENTRY       EC 3.4.23.32
NAME        Scytalidopepsin B
            Scytalidium aspartic proteinase B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of proteins with broad specificity, cleaving
            Phe24-|-Phe, but not Leu15-Tyr and Phe25-Tyr in the B chain of
            insulin.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A second endopeptidase from Scytalidium lignicolum (see
            scytalidopepsin A) that is insensitive to pepstatin and methyl
            2-diazoacetamidohexanoate. 1,2-Epoxy-3-(p-nitrophenoxy)propane
            reacts with Glu53, which replaces one of the aspartic residues at
            the active centre. One of the smallest aspartic endopeptidases
            active as the monomer, with Mr 22 kDa. Similarly inhibitor-
            -resistant endopeptidases are found in the basidiomycetes
            Lentinus edodes and Ganoderma lucidum, and in Polyporus
            tulipiferae (a second endopeptidase distinct from
            polyporopepsin), but these are of typical aspartic endopeptidase
            size.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.32
            ExPASy - ENZYME nomenclature database: 3.4.23.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.32
            BRENDA, the Enzyme Database: 3.4.23.32
///
ENTRY       EC 3.4.23.33
NAME        Xanthomonapepsin
            Xanthomonas aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Cleavage of casein
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   1,2-Epoxy-3-(p-Nitrophenoxy)propane
COMMENT     Secreted by the bacterium Xanthomonas sp. It is insensitive to
            pepstatin and methyl 2-diazoacetamidohexanoate, but not to
            1,2-epoxy-3-(p-nitrophenoxy)propane. A similar enzyme is found in
            Pseudomonas sp.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.33
            ExPASy - ENZYME nomenclature database: 3.4.23.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.33
            BRENDA, the Enzyme Database: 3.4.23.33
///
ENTRY       EC 3.4.23.34
NAME        Cathepsin E
            Slow-moving proteinase
            Erythrocyte membrane aspartic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Similar to cathepsin D, but slightly broader specificity
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Found in stomach, spleen, erythrocyte membrane; not lysosomal.
            Pro-cathepsin E is an 86 kDa disulfide-linked dimer; activation
            or reduction produces monomer.
GENES       DME: CG13374(pcl)
            MMU: 107361(Ctse)
            HSA: 1510(CTSE)
DISEASE     MIM: 116890  Cathepsin E
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.34
            ExPASy - ENZYME nomenclature database: 3.4.23.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.34
            BRENDA, the Enzyme Database: 3.4.23.34
///
ENTRY       EC 3.4.23.35
NAME        Berrierpepsin
            Extracellular 'Barrier' protein
            BAR proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Selected cleavage of 6-Leu-|-Lys-7 bond in the pheromone alpha-
            mating factor.
COMMENT     Belongs to peptidase family A1.
GENES       SCE: YIL015W(BAR1)
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.35
            ExPASy - ENZYME nomenclature database: 3.4.23.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.35
            BRENDA, the Enzyme Database: 3.4.23.35
///
ENTRY       EC 3.4.23.36
NAME        Signal peptidase II
            Bacterial leader peptidase I
            SPase II
            Premurein-leader peptidase
            Prolipoprotein-signal peptidase
            Lipoprotein signal peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Cleavage of N-Terminal leader sequences from membrane
            Prolipoproteins. Hydrolyses Xaa-Xbb-Xbb-|-Cys-, in which Xaa is
            hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is
            often Gly or Ala, and the Cys is alkylated on sulfur with a
            diacylglyceryl group.
INHIBITOR   Pepstatin
            Globomycin
COMMENT     Inhibited by pepstatin and the antibiotic Globomycin.
            Belongs to peptidase family A8.
PATHWAY     PATH: MAP03060  Protein export
GENES       ECO: b0027(lspA)
            ECE: Z0031(lspA)
            ECS: ECs0030
            YPE: YPO0476(lspA)
            HIN: HI1006(lspA)
            PMU: PM1663(lspA)
            XFA: XF2417
            VCH: VC0683
            PAE: PA4559
            BUC: BU148(lspA)
            NME: NMB1832
            NMA: NMA0623(lsp)
            HPY: HP0074(lspA)
            HPJ: jhp0069
            CJE: Cj0361(lspA)
            RPR: RP408(lspA)
            RCO: RC0558(lspA)
            MLO: mlr3211
            SME: SMc01129(lspA)
            CCR: CC0700
            BSU: BG11793(lsp)
            BHA: BH2543(lsp)
            SAU: SA1039(lsp)
            SAV: SAV1184(lsp)
            LLA: L0335(lspA)
            SPY: SPy0826(lsp)
            SPN: SP0928
            SPR: spr0829(lspA)
            CAC: CAC2115(lspA)
            MGE: MG210(lspa)
            MPN: H10_orf184(lspA)
            MPU: MYPU_6680(lsp)
            UUR: UU314(lspA)
            MTU: Rv1539(lspA)
            MTC: MT1591
            MLE: ML1199(lspA)
            CTR: CT408
            CMU: TC0688
            CPN: CPn0535
            CPA: CP0217
            CPJ: lspA
            BBU: BB0469(lsp)
            TPA: TP0978
            SYN: slr1366(lspA)
            DRA: DR2388
            AAE: aq_1837(lsp)
            TMA: TM0463
MOTIF       PS: PS00855  [LIVM]-x-[GASF]-[GA]-[GAS]-[LIVMT]-[GAS]-N-[LVMFG]-
                         [LIVFYG]-D-[RI]-[LIVMFA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.36
            ExPASy - ENZYME nomenclature database: 3.4.23.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.36
            BRENDA, the Enzyme Database: 3.4.23.36
///
ENTRY       EC 3.4.23.37
NAME        Pseudomonapepesin
            Pseudomonas SP. Pepstatin-insensitive carboxyl proteinase.
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of the B chain of Insulin at 13-Glu-|-Ala-14, 18-Leu-|-
            $Tyr-19 and 25-Phe-|-Tyr-26 and Angiotensin I at 4-Tyr-|-Ile-5.
            A good synthetic substrate is Lys-Pro-Ile-Glu-Phe-|-Phe(NO2)-Arg-
            $Leu.
COMMENT     Insensitive to Pepstatin, Diazoacetylnorleucine methyl ester and
            1,2-Epoxy-3(p-nitrophenoxy)propane (EPNP).
            Optimum PH4.
            Inhibited by Tyrostatin, a peptide aldehyde.
            Belongs to peptidase family A7.
STRUCTURES  PDB: 1GA4  1GA1  1GA6  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.37
            ExPASy - ENZYME nomenclature database: 3.4.23.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.37
            BRENDA, the Enzyme Database: 3.4.23.37
            SCOP (Structural Classification of Proteins): 3.4.23.37
///
ENTRY       EC 3.4.23.38
NAME        Plasmepsin I
            Aspartic homoglobinase I
            PFAPG
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of the 33-Phe-|-Leu-34 bond in the alpha-chain of
            Hemoglobin, leading to denaturation of molecule.
COMMENT     Inhibited by Pepstatin.
            Belongs to peptidase family A1.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.38
            ExPASy - ENZYME nomenclature database: 3.4.23.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.38
            BRENDA, the Enzyme Database: 3.4.23.38
///
ENTRY       EC 3.4.23.39
NAME        Plasmepsin II
            Aspertic hemoglobinase II
            PFAPD
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Hydrolysis of the bonds linking certain hydrophobic residues in
            Hemoglobin or Globin. Also cleaves small molecules substrates such
            as Ala-Le-Glu-Arg-Thr-Phe-|-Phe(NO2)-Ser-Phe-Pro-Thr.
COMMENT     Inhibited by Pepstatin.
            Belongs to peptidase family A1.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1J8J  1PFZ  1SME  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.39
            ExPASy - ENZYME nomenclature database: 3.4.23.39
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.39
            BRENDA, the Enzyme Database: 3.4.23.39
            SCOP (Structural Classification of Proteins): 3.4.23.39
///
ENTRY       EC 3.4.23.40
NAME        Phytepsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aspartic endopeptidases
REACTION    Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and
            P1', but also cleaves -Phe-|-Asp- and -Asp-|-Asp- bonds in 2S
            albumin from plant seeds
COMMENT     Known particularly from barley grain, but present in other plants
            also. In peptidase family A1 (pepsin A family), but structurally
            distinct in containing an internal region of about 100 amino acids
            not generally present in the family.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1QDM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.23.40
            ExPASy - ENZYME nomenclature database: 3.4.23.40
            WIT (What Is There) Metabolic Reconstruction: 3.4.23.40
            SCOP (Structural Classification of Proteins): 3.4.23.40
///
ENTRY       EC 3.4.24.1
NAME        Atrolysin A
            Crotalus atrox metalloendopeptidase a
            Hemorrhagic toxin a
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Asn3-|-Gln, His5-|-Leu, His10-|-Leu, Ala14-|-Leu and
            Tyr16-|-Leu in insulin B chain; removes C-terminal Leu from small
            peptides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
            L-Leucine
COMMENT     A hemorrhagic endopeptidase of 68 kDa, one of six hemorrhagic
            toxins in the venom of the western diamondback rattlesnake. The
            60 kDa hemorrhagic toxin 1 of C. ruber ruber shows identical
            specificity.  Related metalloendopeptidases from rattlesnake
            venoms are EC 3.4.24.41, 3.4.24.42, 3.4.24.43, 3.4.24.44,
            3.4.24.45, 3.4.24.46, 3.4.24.47 and 3.4.24.48.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.1
            ExPASy - ENZYME nomenclature database: 3.4.24.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.1
            BRENDA, the Enzyme Database: 3.4.24.1
///
ENTRY       EC 3.4.24.2
NAME        Deleted entry
            Sepia proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.2
            ExPASy - ENZYME nomenclature database: 3.4.24.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.2
///
ENTRY       EC 3.4.24.3
NAME        Microbial collagenase
            Clostridium histolyticum collagenase
            Clostridiopeptidase A
            Collagenase A
            Collagenase I
            Achromobacter iophagus collagenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Digestion of native collagen in the triple helical region at +Gly
            bonds. With synthetic peptides, a preference is shown for Gly at
            P3 and P1'; Pro and Ala at P2 and P2'; and hydroxyproline, Ala or
            Arg at P3'
SUBSTRATE   Collagen
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Six species of metalloendopeptidase acting on native collagen can
            be isolated from the medium of Clostridium histolyticum. Class I
            has forms alpha (68 kDa), beta (115kDa) and gamma (79 kDa);
            class II has delta (100 kDa), epsilon (110 kDa) and xi (125 kDa).
            The two classes are immunologically crossreactive, but have
            significantly different sequences, and different specificities
            such that their actions on collagen are complementary. The enzymes
            also act as peptidyl-tripeptidases. Variants of the enzyme have
            been purified from Bacillus cereus, Empedobacter collagenolyticum,
            and V. alginolyticus (previously Achromobacter iophagus). Also
            known from Streptomyces sp. Formerly EC 3.4.99.5, 3.4.4.19 and
            3.4.24.8.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.3
            ExPASy - ENZYME nomenclature database: 3.4.24.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.3
            BRENDA, the Enzyme Database: 3.4.24.3
///
ENTRY       EC 3.4.24.4
NAME        Deleted entry
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Deleted entry. See EC 3.4.24.25 - Aeromonolysin;
            EC 3.4.24.26 - Pseudolysin; EC 3.4.24.27 - Thermolysin;
            EC 3.4.24.28 - Bacillolysin; EC 3.4.24.29 - Aureolysin;
            EC 3.4.24.30 - Coccolysin; EC 3.4.24.31 - Mycolysin;
            EC 3.4.24.32 - beta-Lytic metalloendopeptidase;
            EC 3.4.24.39 - Deuterolysin; EC 3.4.24.40 - Serralysin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.4
            ExPASy - ENZYME nomenclature database: 3.4.24.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.4
///
ENTRY       EC 3.4.24.5
NAME        Deleted entry
            Lens neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Deleted entry. Now included with EC 3.4.22.17 - Calpain and
            EC 3.4.99.46 - Multicatalytic endopeptidase complex.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.5
            ExPASy - ENZYME nomenclature database: 3.4.24.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.5
///
ENTRY       EC 3.4.24.6
NAME        Leucolysin
            Leucostoma neutral proteinase
            Leucostoma peptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Phe1-|-Val, His5-|-Leu, Ala14-|-Leu, Gly20-|-Glu,
            Gly23-|-Phe and Phe24-|-Phe bonds in insulin B chain as well as
            N-blocked dipeptides
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     From the venom of the western cottonmouth moccasin snake
            (Agkistrodon piscivorus leucostoma).
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.6
            ExPASy - ENZYME nomenclature database: 3.4.24.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.6
            BRENDA, the Enzyme Database: 3.4.24.6
///
ENTRY       EC 3.4.24.7
NAME        Interstital collagenase
            Vertebrate collagenase
            Matrix metalloproteinase 1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the triple helix of collagen at about three-quaters
            of the lingth of the molecule from the N-terminus, at Gly775-|-Ile
            in the alpha1(I) chain.  Cleaves synthetic substrates and alpha-
            macroglobulins at bonds where P1' is a hydrophobic residue
SUBSTRATE   Collagen
            H2O
            alpha-Macroglobulin
PRODUCT     Protein
            Peptide
COFACTOR    Zinc
COMMENT     The enzyme takes its name from substrates of the interstitial
            collagen group - type I, II and III, all of which are cleaved in
            the helical domain.  However, alpha-macroglobulins are cleaved
            much more rapidly.  The enzyme is widely distributed in vertebrate
            animals.
GENES       MMU: 97006(Mmp1)
            HSA: 4312(MMP1)
DISEASE     MIM: 120353  Matrix metalloproteinase 1 (interstitial collagenase)
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 4AYK  1AYK  1CGF  1CGL  1FBL  1HFC  1MNC  2AYK  1CGE  3AYK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.7
            ExPASy - ENZYME nomenclature database: 3.4.24.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.7
            BRENDA, the Enzyme Database: 3.4.24.7
            SCOP (Structural Classification of Proteins): 3.4.24.7
///
ENTRY       EC 3.4.24.8
NAME        Transferred to EC 3.4.24.3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Transferred entry. Now included with EC 3.4.24.3 - Microbial
            collagenase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.8
            ExPASy - ENZYME nomenclature database: 3.4.24.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.8
            BRENDA, the Enzyme Database: 3.4.24.8
///
ENTRY       EC 3.4.24.9
NAME        Deleted entry
            Trichophyton schoenleinii collagenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.9
            ExPASy - ENZYME nomenclature database: 3.4.24.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.9
///
ENTRY       EC 3.4.24.10
NAME        Deleted entry
            Trichophyton mentagrophytes keratinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.10
            ExPASy - ENZYME nomenclature database: 3.4.24.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.10
///
ENTRY       EC 3.4.24.11
NAME        Neprilysin
            Neutral endopeptidase
            Endopeptidase 24.11
            Kidney-brush-border neutral peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of polypeptides between hydrophobic
            residues, particularly with Phe or Tyr at P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   EDTA
            Phosphoramidon
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]glycine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]-(S)-alanine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]glycine
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]-(S)-alanine
            Phosphoramidon
            Thiorphan
COFACTOR    Zinc
COMMENT     A membrane-bound glycoprotein widely distributed in animal
            tissues.  Inhibited by phosphoramidon and thiorphan. Common acute
            lymphoblastic leukemia antigen (CALLA).
GENES       CEL: F26G1.6 T05A8.4
            MMU: 97004(Mme)
            HSA: 4311(MME)
DISEASE     MIM: 120520  Membrane metallo-endopeptidase (common acute
                         lymphocytic leukemia
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1DL9  1DMT  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.11
            ExPASy - ENZYME nomenclature database: 3.4.24.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.11
            BRENDA, the Enzyme Database: 3.4.24.11
            SCOP (Structural Classification of Proteins): 3.4.24.11
///
ENTRY       EC 3.4.24.12
NAME        Envelysin
            Sea-urchin-hatching proteinase
            Hatching enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of proteins of the fertilization envelope and
            dimethylcasein.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A glycoprotein from various members of the class Echinoidea.
            Extracellular enzyme requiring Ca2+. A homologue of interstitial
            collagenase.
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.12
            ExPASy - ENZYME nomenclature database: 3.4.24.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.12
            BRENDA, the Enzyme Database: 3.4.24.12
///
ENTRY       EC 3.4.24.13
NAME        IgA-specific metalloendopeptidase
            Immunoglobulin A1 proteinase
            IgA protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Pro-|-Thr bond in the hinge region of the heavy chain
            of human IgA
SUBSTRATE   Human IgA
PRODUCT     Fab fragment of human IgA
            Fc fragment of human IgA
INHIBITOR   EDTA
COMMENT     A 190 kDa enzyme found in several pathogenic species of
            Streptococcus such as sanguis and pneumoniae.  There is also an
            IgA-specific prolyl endopeptidase of serine-type (see
            EC 3.4.21.72).
GENES       SPR: spr1042(iga)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.13
            ExPASy - ENZYME nomenclature database: 3.4.24.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.13
            BRENDA, the Enzyme Database: 3.4.24.13
///
ENTRY       EC 3.4.24.14
NAME        Procollagen N-endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleaves the N-propeptide of collagen chain alpha1(I) at P1, P2
            and P3' and a small residue at P1' in substrates of 5-15 residues.
SUBSTRATE   Procollagen
            H2O
PRODUCT     Collagen alpha1(I)
            Peptide
COFACTOR    Metal
COMMENT     Removes the propeptides of type I and II collagens prior to fibril
            assembly.  Does not act on type III collagen.
GENES       HSA: 5119(PCOLN3) 9509(ADAMTS2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.14
            ExPASy - ENZYME nomenclature database: 3.4.24.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.14
            BRENDA, the Enzyme Database: 3.4.24.14
///
ENTRY       EC 3.4.24.15
NAME        Thimet oligopeptidase
            Pz-peptidase
            Soluble metalloendopeptidase
            Endo-oligopeptidase A
            Tissue-endopeptidase degrading collagenase-synthetic-substrate
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues at P1, P2
            and P3' and a small residue at P1' in substrates of 5-15 residues
SUBSTRATE   Protein
            Peptide
            H2O
            Bradykinin
PRODUCT     Protein
            Peptide
EFFECTOR    Thiol compound
COMMENT     Thiol compounds activate at low concentrations.  Formerly also
            EC 3.4.22.19 and EC 3.4.99.31.
GENES       HSA: 7064(THOP1)
DISEASE     MIM: 601117  Thimet oligopeptidase-1
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.15
            ExPASy - ENZYME nomenclature database: 3.4.24.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.15
            BRENDA, the Enzyme Database: 3.4.24.15
///
ENTRY       EC 3.4.24.16
NAME        Neurolysin
            Neurotensin endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage in neurotensin: Pro10-|-Tyr
SUBSTRATE   Neurotensin
            H2O
            Dynorphin
PRODUCT     Peptide
COFACTOR    Metal
COMMENT     No absolute requirement for a prolyl bond: the enzyme acts on some
            peptides, such as dynorphin 1-8, that do not contain proline, and
            does not act on some others that do.
GENES       HSA: 57486(KIAA1226)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1I1I  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.16
            ExPASy - ENZYME nomenclature database: 3.4.24.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.16
            BRENDA, the Enzyme Database: 3.4.24.16
            SCOP (Structural Classification of Proteins): 3.4.24.16
///
ENTRY       EC 3.4.24.17
NAME        Stromelysin 1
            Matrix metalloproteinase 3
            Proteoglycanase
            Collagenase activating protein
            Procollagenase activator
            Transin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage where P1', P2' and P3' are hydrophobic
            residues
SUBSTRATE   Protein
            Peptide
            H2O
            Proteoglycan
            Fibronectin
            Collagen type III
            Collagen type IV
            Collagen type V
            Collagen type IX
            Procollagenase
PRODUCT     Protein
            Peptide
            Collagenase
COMMENT     An extracellular endopeptidase of vertebrate tissues homologous
            with interstitial collagenase.  Digests proteoglycan, fibronectin,
            collagen types III, IV, V and IX, and activates procollagenase.
GENES       MMU: 97010(Mmp3)
            HSA: 4314(MMP3)
DISEASE     MIM: 185250  Matrix metalloproteinase 3 (stromelysin 1,
                         progelatinase)
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 1CQR  1D5J  1D7X  1CIZ  1D8M  1G05  1CAQ  1C3I  1SLM  1SLN  
                 1UEA  1UMT  1USN  2SRT  2USN  3USN  1BQO  1BM6  1BIW  1B8Y  
                 1UMS  1G4K  1HFS  1C8T  1D8F  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.17
            ExPASy - ENZYME nomenclature database: 3.4.24.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.17
            BRENDA, the Enzyme Database: 3.4.24.17
            SCOP (Structural Classification of Proteins): 3.4.24.17
///
ENTRY       EC 3.4.24.18
NAME        Meprin A
            Endopeptidase-2
            Meprin-a
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of protein and peptide substrates preferentially on
            carboxyl side of hydrophobic residues
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A membrane-bound metalloendopeptidase of rat and mouse kidney and
            intestinal bruch borders, and salivary ducts.  Differences from
            neprilysin (EC 3.4.24.11) include insensitivity to phosphoramidon
            and thiorphan.  PABA-peptide hydrolase is a very similar enzyme
            found in human intestinal microvilli.  Formerly included in
            EC 3.4.24.11.
GENES       MMU: 96963(Mep1a) 96964(Mep1b)
            HSA: 4224(MEP1A) 4225(MEP1B)
MOTIF       PS: PS00022  C-x-C-x(5)-G-x(2)-C
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00740  G-x-[LIVMFY](2)-x(3)-[STA]-x(10,11)-[LV]-x(4)-[LIVMF]-
                         x(6,7)-C-[LIVM]-x-F-x-[LIVMFY]-x(3)-[GSC]
            PS: PS01186  C-x-C-x(2)-[GP]-[FYW]-x(4,8)-C
            PS: PS50060  MAM domain profile
STRUCTURES  PDB: 1IAF  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.18
            ExPASy - ENZYME nomenclature database: 3.4.24.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.18
            BRENDA, the Enzyme Database: 3.4.24.18
            SCOP (Structural Classification of Proteins): 3.4.24.18
///
ENTRY       EC 3.4.24.19
NAME        Procollagen C-endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II
            procollagens and at Arg-|-Asp in type III
SUBSTRATE   Procollagen
            H2O
PRODUCT     Collagen
            Peptide
COFACTOR    Metal
EFFECTOR    Calcium
COMMENT     An 100 kDa endopeptidase, the activity of which is increased by
            Ca2+ and by an enhancer glycoprotein.
GENES       HSA: 5117(PCOLC)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.19
            ExPASy - ENZYME nomenclature database: 3.4.24.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.19
            BRENDA, the Enzyme Database: 3.4.24.19
///
ENTRY       EC 3.4.24.20
NAME        Peptidyl-Lys metalloendopeptidase
            Armillaria mellea neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage in proteins: -Xaa-|-Lys- (in which Xaa may be
            Pro)
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     From the honey fungus Armillaria mellea.  Formerly EC 3.4.99.32.
            A similar specificity is shown by Myxobacter AL-1 proteinase II,
            formerly EC 3.4.99.30.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1G12  1GE5  1GE6  1GE7  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.20
            ExPASy - ENZYME nomenclature database: 3.4.24.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.20
            BRENDA, the Enzyme Database: 3.4.24.20
///
ENTRY       EC 3.4.24.21
NAME        Astacin
            Astacus proteinase
            Crayfish small-molecule proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of peptide bonds in substrates containing five or more
            amino acids, preferentially with Ala in P1', and Pro in P2'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A 22.6 kDa digestive endopeptidase from the cardia of the crayfish
            Astacus fluviatilis.  Formerly EC 3.4.99.6.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1IAD  1IAE  1QJI  1QJJ  1IAA  1AST  1IAB  1IAC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.21
            ExPASy - ENZYME nomenclature database: 3.4.24.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.21
            BRENDA, the Enzyme Database: 3.4.24.21
            SCOP (Structural Classification of Proteins): 3.4.24.21
///
ENTRY       EC 3.4.24.22
NAME        Stromelysin 2
            Matrix metalloproteinase 10
            Transin 2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Similar to stromelysin 1, but action on collagen types III, IV and
            V is weak
SUBSTRATE   Protein
            Peptide
            H2O
            Proteoglycan
            Fibronectin
            Collagen type III
            Collagen type IV
            Collagen type V
            Collagen type IX
            Procollagenase
            Gelatin type I
            Gelatin type III
            Gelatin type IV
            Gelatin type V
PRODUCT     Protein
            Peptide
            Collagenase
COMMENT     Homologue of interstitial collagenase that digests gelatin types
            I, III, IV, V, fibronectin and proteoglycan.
GENES       HSA: 4319(MMP10)
DISEASE     MIM: 185260  Matrix metalloproteinase 10 (stromelysin 2)
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.22
            ExPASy - ENZYME nomenclature database: 3.4.24.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.22
            BRENDA, the Enzyme Database: 3.4.24.22
///
ENTRY       EC 3.4.24.23
NAME        Matrilysin
            Matrin
            Uterine metalloendopeptidase
            Matrix metalloproteinase 7
            Putative (or punctuated) metalloproteinase-1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Ala14-|-Leu and Tyr16-|-Leu in B chain of insulin.
            No action on collagen types I, II, IV, V.
            Cleaves gelatin chain alpha2(I) > alpha1(I)
SUBSTRATE   Gelatin chain alpha2(I)
            Gelatin chain alpha1(I)
            H2O
            Azocoll
PRODUCT     Protein
            Peptide
COMMENT     Found in rat uterus, the smallest member of the interstitial
            collagenase family (19 kDa).  Similar in specificity to
            stromelysin, but more active on azocoll.
GENES       HSA: 4316(MMP7)
DISEASE     MIM: 178990  Matrix metalloproteinase 7 (matrilysin, uterine)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 1MMQ  1MMP  1MMR  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.23
            ExPASy - ENZYME nomenclature database: 3.4.24.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.23
            BRENDA, the Enzyme Database: 3.4.24.23
            SCOP (Structural Classification of Proteins): 3.4.24.23
///
ENTRY       EC 3.4.24.24
NAME        Gelatinase A
            72-kDa Gelatinase
            Matrix metalloproteinase 2
            Type IV collagenase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavege of gelatin type I and collagen types IV, V, VII, X.
            Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln
SUBSTRATE   Gelatin type I
            Collagen type IV
            Collagen type V
            Collagen type VII
            Collagen type X
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A secreted endopeptidase homologous with interstitial collagenase,
            but possessing an additional fibronectin-like domain.
GENES       MMU: 97009(Mmp2)
            HSA: 4313(MMP2)
DISEASE     MIM: 120360  Matrix metalloproteinase 2 (gelatinase A, 72kD type IV
                         collagenase)
MOTIF       PS: PS00023  C-x(2)-P-F-x-[FYWI]-x(7)-C-x(8,10)-W-C-x(4)-[DNSR]-
                         [FYW]-x(3,5)-[FYW]-x-[FYWI]-C
            PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 1QIB  1RTG  1J7M  1CK7  1CXW  1GEN  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.24
            ExPASy - ENZYME nomenclature database: 3.4.24.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.24
            BRENDA, the Enzyme Database: 3.4.24.24
            SCOP (Structural Classification of Proteins): 3.4.24.24
///
ENTRY       EC 3.4.24.25
NAME        Aeromonolysin
            Aeromonas proteolytica neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with bulky hydrophobic groups in
            P2 and P1'.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     Thermostable enzyme from Aeromonas proteolytica.  Specificity
            related to, but distinct from, those of thermolysin and Bacillus
            subtilis endopeptidase.  Formerly included in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.25
            ExPASy - ENZYME nomenclature database: 3.4.24.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.25
            BRENDA, the Enzyme Database: 3.4.24.25
///
ENTRY       EC 3.4.24.26
NAME        Pseudolysin
            Pseudomonas elastase
            Pseudomonas aeruginosa neutral metalloproteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of proteins including elastin, collagen types III and
            IV, fibronectin and immunoglobulin A, generally with bulky
            hydrophobic group at P1'.  Insulin B chain cleavege pattern
            identical to that of thermolysin, but specificity differs in other
            respects
SUBSTRATE   Elastin
            Collagen type III
            Collagen type IV
            Fibronectin
            Immunoglobulin A
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A homologue of thermolysin that causes tissue damage, from the
            pathogenic bacteria Pseudomonas aeruginosa and Legionella
            pneumophila.  Formerly included in EC 3.4.24.4.
GENES       PAE: PA3724(lasB)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1EZM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.26
            ExPASy - ENZYME nomenclature database: 3.4.24.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.26
            BRENDA, the Enzyme Database: 3.4.24.26
            SCOP (Structural Classification of Proteins): 3.4.24.26
///
ENTRY       EC 3.4.24.27
NAME        Thermolysin
            Bacillus thermoproteolyticus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage: +Leu > + Phe
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A thermostable extracellular metalloendopeptidase containing four
            calcium ions.  Enzymes that may be species variants of thermolysin
            are reported from Micrococcus caseolyticus and Aspergillus oryzae.
            Formerly included in EC 3.4.24.4.  Closely related but distinct
            enzymes are aeromonolysin, pseudolysin, bacillolysin, aureolysin
            and mycolysin.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1LNA  1LNB  1LNC  1LND  1LNE  1LNF  1NPC  1QF0  1QF1  1QF2  
                 1THL  1TLI  1TLP  1TLX  1TMN  1TRL  1HYT  2TLX  2TMN  3TLI  
                 3TMN  4TLI  4TLN  4TMN  5TLI  5TLN  5TMN  1FJW  6TMN  7TLI  
                 7TLN  7TMN  8TLI  8TLN  1FJV  2TLI  1FJU  6TLI  1FJQ  1FJO  
                 1FJ3  1BQB  1FJT  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.27
            ExPASy - ENZYME nomenclature database: 3.4.24.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.27
            BRENDA, the Enzyme Database: 3.4.24.27
            SCOP (Structural Classification of Proteins): 3.4.24.27
///
ENTRY       EC 3.4.24.28
NAME        Bacillolysin
            Bacillus metalloendopeptidase
            Bacillus subtilis neutral proteinase
            Megateriopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Similar, but not identical, to that of thermolysin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Variants of this enzyme have been found in species of Bacillus
            including B. subtilis, B. amyloliquefaciens, B. megaterium
            (megateriopeptidase), B. mesentericus, B. cereus and
            B. stearothermophilus.  Formerly included in EC 3.4.24.4.
GENES       BSU: BG10448(nprE)
            CAC: CAC2517(nrpE)
            AAE: aq_1459(npr)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.28
            ExPASy - ENZYME nomenclature database: 3.4.24.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.28
            BRENDA, the Enzyme Database: 3.4.24.28
///
ENTRY       EC 3.4.24.29
NAME        Aurelysin
            Staphylococcus aureus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of insulin B chain with specificity similar to that of
            thermolysin, preferring hydrophobic P1' residue.  Activates the
            glutamyl endopeptidase (EC 3.4.21.19) of Staphylococcus aureus.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A metalloenzyme from S. aureus earlier confused with
            staphylokinase (a non-enzymatic activator of plasminogen).
            Formerly EC 3.4.99.22 and included in EC 3.4.24.4.
GENES       SAU: SA2430(aur)
            SAV: SAV2621(aur)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1C79  1C76  1C78  1C77  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.29
            ExPASy - ENZYME nomenclature database: 3.4.24.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.29
            BRENDA, the Enzyme Database: 3.4.24.29
            SCOP (Structural Classification of Proteins): 3.4.24.29
///
ENTRY       EC 3.4.24.30
NAME        Coccolysin
            Streptococcus thermophilus intracellular proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage: +Leu, +Phe, +Tyr, +Ala
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A 30 kDa endopeptidase found intracellularly in S. thermophilus
            and S. diacetilactis and in the medium of S. faecalis.  Formerly
            included in EC 3.4.24.4.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.30
            ExPASy - ENZYME nomenclature database: 3.4.24.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.30
            BRENDA, the Enzyme Database: 3.4.24.30
///
ENTRY       EC 3.4.24.31
NAME        Mycolysin
            Pronase component
            Streptomyces griseus neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues in P1'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Mercaptoacetyl-Phe-Leu
COMMENT     From Streptomyces griseus, S. naraensis, and S. cacaoi.
            Specificity similar to that of thermolysin, but much more
            sensitive to inhibition by mercaptoacetyl-Phe-Leu.  Little
            structural similarity to other bacterial metalloendopeptidases.
            Formerly included in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.31
            ExPASy - ENZYME nomenclature database: 3.4.24.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.31
            BRENDA, the Enzyme Database: 3.4.24.31
///
ENTRY       EC 3.4.24.32
NAME        beta-Lytic metalloendopeptidase
            Myxobacter beta-lytic proteinase
            Achromopeptidase component
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of N-acetylmuramoyl-|-Ala, and of the insulin B chain at
            Gly23-|-Phe > Val18-|-Cys(SO2H)
SUBSTRATE   N-Acetylmuramoyl-Ala
            Protein
            Peptide
            H2O
            Bacterial cell wall
PRODUCT     N-Acetylmuramate
            L-Alanine
            Protein
            Peptide
COMMENT     From Achromobacter lyticus and Lysobacter enzymogenes.  Digests
            bacterial cell walls. Not a homologue of thermolysin.  Formerly
            EC 3.4.99.13 and included in EC 3.4.24.4.  Myxobacter AL-1
            proteinase I (formerly EC 3.4.99.29) also has characteristics of
            this enzyme.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.32
            ExPASy - ENZYME nomenclature database: 3.4.24.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.32
            BRENDA, the Enzyme Database: 3.4.24.32
///
ENTRY       EC 3.4.24.33
NAME        Peptidyl-Asp metalloendopeptidase
            Endoproteinase Asp-N
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Xaa-|-Asp, Xaa-|-Glu and Xaa-|-cysteic acid bonds
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A metalloenzyme isolated from Pseudomonas fragi. Useful in
            protein sequencing applications because of its limited
            specificity.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.33
            ExPASy - ENZYME nomenclature database: 3.4.24.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.33
            BRENDA, the Enzyme Database: 3.4.24.33
///
ENTRY       EC 3.4.24.34
NAME        Neutrophil collagenase
            Matrix metalloproteinase 8
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of interstitial collagens in the triple helical domain.
            Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more
            slowly than type I
SUBSTRATE   Collagen
            H2O
PRODUCT     Protein
            Peptide
COMMENT     Similar to interstitial gene and highly glycosylated. Stored in
            the specific granules of neutrophil leukocyes. Formerly included
            in EC 3.4.24.7.
GENES       MMU: 107361(Ctse)
            HSA: 4317(MMP8)
DISEASE     MIM: 120355  Matrix metalloproteinase 8 (neutrophil collagenase)
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 1JAP  1JAQ  1JAO  1JAN  1MMB  1I73  1BZS  1A86  1KBC  1JJ9  
                 1A85  1I76  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.34
            ExPASy - ENZYME nomenclature database: 3.4.24.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.34
            BRENDA, the Enzyme Database: 3.4.24.34
            SCOP (Structural Classification of Proteins): 3.4.24.34
///
ENTRY       EC 3.4.24.35
NAME        Gelatinase B
            92-kDa gelatinase
            Matrix metalloproteinase 9
            Type V collagenase
            92-kDa type IV collagenase
            Macrophage gelatinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of gelatin types I and V and collagen type IV and V.
SUBSTRATE   Gelatin type I
            Gelatin type V
            Collagen type IV
            Collagen type V
            H2O
PRODUCT     Peptide
COFACTOR    Metal
COMMENT     Similar to gelatinase A, but possesses a further domain.
GENES       MMU: 97011(Mmp9)
            HSA: 4318(MMP9)
DISEASE     MIM: 120361  Matrix metalloproteinase 9 (gelatinase B, 92kD type IV
                         collagenase)
MOTIF       PS: PS00023  C-x(2)-P-F-x-[FYWI]-x(7)-C-x(8,10)-W-C-x(4)-[DNSR]-
                         [FYW]-x(3,5)-[FYW]-x-[FYWI]-C
            PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.35
            ExPASy - ENZYME nomenclature database: 3.4.24.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.35
            BRENDA, the Enzyme Database: 3.4.24.35
///
ENTRY       EC 3.4.24.36
NAME        Leishmanolysin
            Promastigote surface endopeptidase
            Glycoprotein gp63
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preference for hydrophobic residues at P1 and P1' and basic
            residues at P2' and P3'. A model nonapeptide is cleaved at
            -Ala-Tyr-|-Leu-Lys-Lys-
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Z-Tyr-Leu-NHOH
COMMENT     A membrane-bound glycoprotein found on the promastigote of various
            species of Leishmania protozoans.  Contains consensus sequence for
            a zine-binding site; Z-Tyr-Leu-NHOH is a strong inhibitor. The
            enzyme can activate its proenzyme by cleavage of the Val100-|-Val
            bond.  An acid pH optimum is found with certain protein
            substrates.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1LML  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.36
            ExPASy - ENZYME nomenclature database: 3.4.24.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.36
            BRENDA, the Enzyme Database: 3.4.24.36
            SCOP (Structural Classification of Proteins): 3.4.24.36
///
ENTRY       EC 3.4.24.37
NAME        Saccharolysin
            Proteinase yscD
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Pro-|-Phe and Ala-|-Ala bonds
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 83 kDa cytoplasmic thiol-dependent metalloendopeptidase from
            Saccharomyces cerevisiae. Homologue of thimet oligopeptidase.
            Formerly EC 3.4.22.22.
GENES       SCE: YCL057W(PRD1)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.37
            ExPASy - ENZYME nomenclature database: 3.4.24.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.37
            BRENDA, the Enzyme Database: 3.4.24.37
///
ENTRY       EC 3.4.24.38
NAME        Autolysin
            Chlamydomonas cell wall degrading protease
            Lysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of the proline- and hydroxyproline-rich proteins of the
            Chlamydomonas cell wall; also cleaves azocasein, gelatin and
            Leu-Trp-Met-|-Arg-Phe-Ala
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Phosphoramidon
COFACTOR    Zinc
COMMENT     A glycoprotein found in the periplasmic space of Chlamydomonas
            reinhardtii gametes in a 62 kDa inactive form; Mr is reduced to
            60 kDa upon activation.  A zinc enzyme, inhibited by
            phosphoramidon, but also thiol-dependent.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.38
            ExPASy - ENZYME nomenclature database: 3.4.24.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.38
            BRENDA, the Enzyme Database: 3.4.24.38
///
ENTRY       EC 3.4.24.39
NAME        Deuterolysin
            Penicillium roqueforti protease II
            Microbial neutral proteinase II
            Acid metalloproteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues in P1';
            also Asn3-|-Gln and Gly8-|-Ser bonds in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     Proteolytic activity found in Penicillium roqueforti,
            P. caseicolum, Aspergillus sojae and A. oryzae. Optimum pH of 5
            for digesting various proteins.  Strong action on protamine and
            histones.  Insensitive to phosphoramidon. Mr about 20 kDa.
            A distinct Aspergillus sojae endopeptidase is larger and has a
            neutral pH optimum.  Formerly included in EC 3.4.24.4.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.39
            ExPASy - ENZYME nomenclature database: 3.4.24.39
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.39
            BRENDA, the Enzyme Database: 3.4.24.39
///
ENTRY       EC 3.4.24.40
NAME        Serralysin
            Pseudomonas aeruginosa alkaline proteinase
            Escherichia freundii proteinase
            Serratia marcescens extracellular proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of bonds with hydrophobic residues in P'
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COMMENT     A 50 kDa extracellular endopeptidase from Pseudomonas aeruginosa,
            Escherichia freundii, Serratia marcescens and
            Erwinia chrysanthemi.  There is broad specificity in cleavage of
            the insulin B chain, with some species variations.  The pH optimum
            for digesting various proteins is about 9 - 10.  Formerly included
            in EC 3.4.24.4.
GENES       SME: SMa0034
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
STRUCTURES  PDB: 1AF0  1AKL  1SMP  1SRP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.40
            ExPASy - ENZYME nomenclature database: 3.4.24.40
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.40
            BRENDA, the Enzyme Database: 3.4.24.40
            SCOP (Structural Classification of Proteins): 3.4.24.40
///
ENTRY       EC 3.4.24.41
NAME        Atrolysin B
            Crotalus atrox metalloendopeptidase b
            Hemorrhagic toxin b (Ht-b)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His5-|-Leu, His10-|-Leu, Ala14-|-Leu, Tyr16-|-Leu and
            Gly23-|-Phe of insulin B chain; identical to the cleavage of
            insulin B chain by atrolysin C. Also cleaves -|-Ser bonds in
            glucagon.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     From the venom of the western diamondback rattlesnake (Crotalus
            atrox).  Mr = 24 kDa.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.41
            ExPASy - ENZYME nomenclature database: 3.4.24.41
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.41
            BRENDA, the Enzyme Database: 3.4.24.41
///
ENTRY       EC 3.4.24.42
NAME        Atrolysin C
            Crotalus atrox metalloendopeptidase C
            Hemorrhagic tosin c and d
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His5-|-Leu, His10-|-Leu, Ala14-|-Leu, Tyr16-|-Leu and
            Gly23-|-Phe bonds in B chain of insulin.  With small molecule
            substrates prefers hydrophobic residue at P2' and small residue
            such as Ala, Gly at P1
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Phosphoramidon
COMMENT     A 24 kDa hemorrhagic endopeptidase from the venom of the western
            diamondback rattlesnake (Crotalus atrox) that digests type IV
            collagen, and exists as two forms, c and d.  Phosphoramidon
            inhibits in the 0.1 mM range.  The complete amino acid sequence of
            form d is known.  Hemorrhagic toxin-2 of C. ruber ruber has the
            same Mr and specificity and is a homologue.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1ATL  1DTH  1HTD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.42
            ExPASy - ENZYME nomenclature database: 3.4.24.42
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.42
            BRENDA, the Enzyme Database: 3.4.24.42
            SCOP (Structural Classification of Proteins): 3.4.24.42
///
ENTRY       EC 3.4.24.43
NAME        Atroxase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His5-|-Leu, Ser9-|-His, His10-|-Leu, Ala14-|-Leu and
            Tyr16-|-Leu of insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A nonhemorrhagic endopeptidase from the venom of the western
            diamondback rattlesnake (Crotalus atrox) that cleaves fibrinogen.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.43
            ExPASy - ENZYME nomenclature database: 3.4.24.43
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.43
            BRENDA, the Enzyme Database: 3.4.24.43
///
ENTRY       EC 3.4.24.44
NAME        Atrolysin E
            Crotalus atrox metalloendopeptidase e
            Hemorrhagic toxin e
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Asn3-|-Gln, Ser9-|-His and Ala14-|-Leu bonds in insulin
            B chain and Tyr14-|-Gln and Ala8-|-Ser in A chain. Cleaves type IV
            collagen at Ala258-|-Gln in alpha1(IV) and at Gly191-|-Leu in
            alpha2(IV).
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 25.7 kDa hemorrhagic endopeptidase from the venom of the
            western diamondback rattlesnake (Crotalus atrox) that digests
            basement membrane components, including the triple helix of
            type IV collagen. Such action is believed to contribute to the
            hemorrhagic property by weakening capillary walls.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00427  C-x(2)-G-x-C-C-x-[NQRS]-C-x-[FM]-x(6)-C-[RK]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.44
            ExPASy - ENZYME nomenclature database: 3.4.24.44
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.44
            BRENDA, the Enzyme Database: 3.4.24.44
///
ENTRY       EC 3.4.24.45
NAME        Atrolysin F
            Crotalus atrox metalloendopeptidase
            Hemorrhagic toxin f
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Val2-|-Asn, Gln4-|-His, Leu6-|-Cys, His10-|-Leu,
            Ala14-|-Leu and Tyr16-|-Leu bonds in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 64 kDa hemorrhagic endopeptidase from the venom of the western
            diamondback rattlesnake (Crotalus atrox) that digests the gamma
            chain of fibrinogen.  Immunologically distinct from EC 3.4.24.1.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.45
            ExPASy - ENZYME nomenclature database: 3.4.24.45
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.45
            BRENDA, the Enzyme Database: 3.4.24.45
///
ENTRY       EC 3.4.24.46
NAME        Adamalysin
            Crotalus adamanteus metalloendopeptidase
            Proteinase I and II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Phe1-|-Val, His5-|-Leu, His10-|-Leu, Ala14-|-Leu,
            Leu15-|-Tyr, and Tyr16-|-Leu of insulin B chain
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     From the venom of the eastern diamondback rattlesnake (Crotalus
            adamanteus). Two isoenzymes of approx.  24 kDa that inactivate
            alpha1-proteinase inhibitor by single cleavage.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 3AIG  4AIG  2AIG  1IAG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.46
            ExPASy - ENZYME nomenclature database: 3.4.24.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.46
            BRENDA, the Enzyme Database: 3.4.24.46
            SCOP (Structural Classification of Proteins): 3.4.24.46
///
ENTRY       EC 3.4.24.47
NAME        Horrilysin
            Crotalus horridus metalloendopeptidase
            Hemorrhagic proteinase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of only the single bond Ala14-|-Leu in the insulin B
            chain, Ser12-|-Leu in the A chain, and Ile-|-Gly, Pro-|-Ala, and
            Ser-|-Trp in melittin
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 56 kDa hemorrhagic endopeptidase from the venom of the timber
            rattlesnake (Crotalus horridus horridus) that cleaves basement
            membrane, hide powder and fibrinogen.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.47
            ExPASy - ENZYME nomenclature database: 3.4.24.47
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.47
            BRENDA, the Enzyme Database: 3.4.24.47
///
ENTRY       EC 3.4.24.48
NAME        Ruberlysin
            Crotalus ruber metalloendopeptidase II
            Hemorrhagic toxin II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His10-|-Leu, Ala14-|-Leu, Tyr16-|-Leu and Gly23-|-Phe
            bonds of the B chain of insulin; His-|-Pro, Pro-|-Phe, and
            Trp-|-Ser of angiotensin I; and Gly-|-Phe of Met enkephalin
SUBSTRATE   Protein
            Peptide
            H2O
            Fibrinogen
PRODUCT     Protein
            Peptide
COMMENT     A 25 kDa hemorrhagic endopeptidase from the venom of the red
            rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.48
            ExPASy - ENZYME nomenclature database: 3.4.24.48
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.48
            BRENDA, the Enzyme Database: 3.4.24.48
///
ENTRY       EC 3.4.24.49
NAME        Bothropasin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of His5-|-Leu, His10-|-Leu, Ala14-|-Leu, Tyr16-|-Leu and
            Phe24-|-Phe in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     Caseinolytic endopeptidase of jararaca snake (Bothrops jararaca)
            venom; 48 kDa.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.49
            ExPASy - ENZYME nomenclature database: 3.4.24.49
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.49
            BRENDA, the Enzyme Database: 3.4.24.49
///
ENTRY       EC 3.4.24.50
NAME        Bothrolysin
            Bothrops metalloendopeptidase J
            J Protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Gln4-|-His, Ser9-|-His and Ala14-|-Leu of insulin B
            chain and Pro-|-Phe of angiotensin I.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 22.5 kDa endopeptidase from the venom of the jararaca snake
            (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.50
            ExPASy - ENZYME nomenclature database: 3.4.24.50
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.50
            BRENDA, the Enzyme Database: 3.4.24.50
///
ENTRY       EC 3.4.24.51
NAME        Ophiolysin
            Ophiophagus metalloendopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Asn3-|-Gln, Gln4-|-His, His10-|-Leu, Ala14-|-Leu, and
            Tyr16-|-Leu in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 70 kDa endopeptidase from the venom of the king cobra
            (Ophiophagus hannah).
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.51
            ExPASy - ENZYME nomenclature database: 3.4.24.51
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.51
            BRENDA, the Enzyme Database: 3.4.24.51
///
ENTRY       EC 3.4.24.52
NAME        Trimerelysin I
            Trimeresurus metalloendopeptidase I
            Hemorrhagic proteinase HR1A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of only two bonds His10-|-Leu and Ala14-|-Leu in the
            insulin B chain
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 60 kDa hemorrhagic endopeptidase of pI 4.4 from the venom of
            the habu snake (Trimeresurus flavoviridis).
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00427  C-x(2)-G-x-C-C-x-[NQRS]-C-x-[FM]-x(6)-C-[RK]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.52
            ExPASy - ENZYME nomenclature database: 3.4.24.52
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.52
            BRENDA, the Enzyme Database: 3.4.24.52
///
ENTRY       EC 3.4.24.53
NAME        Trimerelysin II
            Trimeresurus metalloendopeptidase II
            Proteinase H2
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Asn3-|-Gln, His10-|-Leu and Ala14-|-Leu in the insulin
            B chain, and the bond Z-Gly-Pro-|-Leu-Gly-Pro in a small molecule
            substrate of microbial collagenase
SUBSTRATE   Protein
            Peptide
            H2O
            Z-Gly-Pro-Leu-Gly-Pro
PRODUCT     Protein
            Peptide
            Z-Gly-Pro
            Leu-Gly-Pro
COMMENT     A 24 kDa nonhemorrhagic endopeptidase from the venom of the habu
            snake (Trimeresurus flavoviridis).
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.53
            ExPASy - ENZYME nomenclature database: 3.4.24.53
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.53
            BRENDA, the Enzyme Database: 3.4.24.53
///
ENTRY       EC 3.4.24.54
NAME        Mucrolysin
            Trimeresurus metalloendopeptidase A
            Mucrotoxin A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of Ser9-|-His, His10-|-Leu, Ala14-|-Leu, Leu15-|-Tyr and
            Tyr16-|-Leu bonds in insulin B chain.
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
COFACTOR    Metal
COMMENT     A 94 kDa hemorrhagic and fibrinogenolytic endopeptidase from the
            Chinese habu snake (Trimeresurus mucrosquamatus) venom.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.54
            ExPASy - ENZYME nomenclature database: 3.4.24.54
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.54
            BRENDA, the Enzyme Database: 3.4.24.54
///
ENTRY       EC 3.4.24.55
NAME        Pitrilysin
            Protease III
            Protease Pi
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Preferential cleavage of Tyr16-|-Leu17 and Phe25-|-Tyr26 bonds
            of oxidized Insulin B chain. Also on other substrates of MW less
            than 7 KD such as Insulin and Glucagon.
INHIBITOR   EDTA
            1,10-Phenanthroline
COFACTOR    Zinc
COMMENT     From the periplasmic space of E.coli.
            Inhibited by EDTA and 1,10-Phenanthroline; Not thiol dependent.
            Belongs to peptidase family M16.
GENES       ECO: b2821(ptr)
            ECE: Z4138(ptr)
            ECS: ECs3678
            YPE: YPO1019(ptrA)
MOTIF       PS: PS00143  G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-
                         [LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.55
            ExPASy - ENZYME nomenclature database: 3.4.24.55
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.55
            BRENDA, the Enzyme Database: 3.4.24.55
///
ENTRY       EC 3.4.24.56
NAME        Insulysin
            Insulinase
            Insulin-degrading enzyme
            Insulin protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Degradation of Insulin, Glucagon and other polypeptides. No action
            on proteins.
INHIBITOR   Bacitracin
            EDTA
            1,10-Phenanthroline
            N-Ethylmaleimide
COFACTOR    Zinc
COMMENT     Cytosolic enzyme, known form mammals and Drosophila melanogaster.
            Inhibited by Bacitracin, Chelating agents EDTA and 1,10-
            Phenanthroline, and by thiol-blocking regents such as
            N-Ethylmaleimide, but not by Phosphoramidon.
            Belongs to peptidase family M16.
GENES       DME: CG5517(Ide)
            HSA: 3416(IDE)
DISEASE     MIM: 146680  Insulin-degrading enzyme
MOTIF       PS: PS00143  G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-
                         [LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.56
            ExPASy - ENZYME nomenclature database: 3.4.24.56
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.56
            BRENDA, the Enzyme Database: 3.4.24.56
///
ENTRY       EC 3.4.24.57
NAME        O-Syaloglycoprotein endopeptidase
            Glycoprotease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of O-Sialoglycoproteins; Cleaves 31-Arg-|-Asp-32 bond in
            Glycophorin A. Does not cleave unglycosylated proteins, desialylated
            Glycoproteins or Glycoproteins that are only N-Glycosylated.
COMMENT     Inhibited by EDTA (100 milli M) and 1,10-Phenantroline.
            Belongs to peptidase family M22.
GENES       ECO: b3064(ygjD)
            ECE: Z4417(ygjD)
            ECS: ECs3947
            HIN: HI0530(gcp)
            PMU: PM1238(gcp)
            XFA: XF0435
            PAE: PA0580(gcp)
            BUC: BU058(ygjD)
            NME: NMB1802
            NMA: NMA0661(gcp)
            HPY: HP1584(gcp)
            HPJ: jhp1491
            CJE: Cj1344c
            RPR: RP037(gcp)
            RCO: RC0061(gcp)
            MLO: mlr4224
            SME: SMc03230(gcp)
            CCR: CC0071
            BSU: BG12202(gcp)
            BHA: BH0548
            SAU: SA1854
            SAV: SAV2034
            LLA: L93500(gcp)
            SPY: SPy1872
            SPN: SP0129
            SPR: spr0131(gcp)
            CAC: CAC0901
            MGE: MG046(gcp)
            MPN: D09_orf319(gcp)
            MPU: MYPU_1180(gcp)
            UUR: UU411(gcp)
            MTU: Rv3419c(gcp)
            MTC: MT3528
            MLE: ML0379(gcp)
            CTR: CT197
            CPN: CPn0194
            CPA: CP0573
            CPJ: gcp_2
            BBU: BB0769(gcp)
            TPA: TP0680
            SYN: slr0807(gcp)
            AAE: aq_801(gcp)
            TMA: TM0145
            MJA: MJ1130
            MTH: MTH1425
            AFU: AF1112(gcp)
            HAL: VNG2045G(gcp)
            TAC: Ta0324
            TVO: TVG1340828
            PHO: PH1987
            PAB: PAB1159(gcp)
            APE: APE1135
            SSO: SSO0434
            STO: ST0363
            DME: CG14231
MOTIF       PS: PS01016  [KR]-[GSAT]-x(4)-[FYWLMH]-[DQNGKRH]-x-P-x-[LIVMFY]-
                         x(3)-H-x(2)-[GSA]-H-[LIVMFA]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.57
            ExPASy - ENZYME nomenclature database: 3.4.24.57
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.57
            BRENDA, the Enzyme Database: 3.4.24.57
///
ENTRY       EC 3.4.24.58
NAME        Russellysin
            Russel 'Viper' venom Factor X activator
            RVV-X
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Specifically activates several compounds of the blood clottting
            system, including coagulation Factor X, coagulation Factor IX and
            Protein C by cleavage of Arg-|-Xaa bonds. Has no action on Insulin
            $ B chain.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.58
            ExPASy - ENZYME nomenclature database: 3.4.24.58
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.58
            BRENDA, the Enzyme Database: 3.4.24.58
///
ENTRY       EC 3.4.24.59
NAME        Mitochondrial intermediate peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Release of an N-Terminal octapeptide as second stage of processing
            of some proteins imported in the Mitochondrion.
COMMENT     Natural substrates are precursor proteins that have already been
            processed by Mitochondrial processing peptidase.
            Belongs to peptidase family M3.
GENES       SCE: YKL134C(MIP1)
            SPO: SPAC1F3.10C(spac1f3.10c)
            DME: CG7791
            HSA: 4285(MIPEP)
DISEASE     MIM: 602241  Mitochondrial intermediate peptidase
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.59
            ExPASy - ENZYME nomenclature database: 3.4.24.59
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.59
            BRENDA, the Enzyme Database: 3.4.24.59
///
ENTRY       EC 3.4.24.60
NAME        Dectylysin
            Peptide hormone inactivating endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of peptidase of at least six residues, with bulky
            hydrophobic residues in the P1' position. Shows a preference for
            hydrophobic doublet such as Phe-|-Phe and Phe-|-Leu in Somtostatin-
            $(1-14)-peptide and Dynorphin A-(1-6)-peptide, respectively.
COMMENT     An Endopeptidase of 100 KD secreted from the skin of Xenopus laevis.
            Resembles neprilysin in insensitivity to 1 mu-mol captopril, but
            differs in being insensitive to thiorphan and unable to digest
            [Met(5)]-Enkephalin, [Leu(5)]-Enkephalin, Oxytocin and substance
            P-(7,11)-peptide.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.60
            ExPASy - ENZYME nomenclature database: 3.4.24.60
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.60
            BRENDA, the Enzyme Database: 3.4.24.60
///
ENTRY       EC 3.4.24.61
NAME        Nardilysin
            N-Arginine dibasic convertase
            NRD convertase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of polypeptides, preferably at Xaa-|-Arg-Lys, and less
            commonly at Arg-|-Arg-Xaa, in which Xaa is not Arg or Lys.
COMMENT     Unsually for a metallopeptidase, inhibited by Bestatin, Amastin
            and Ethylmaleimide.
            Belongs to peptidase family M16.
GENES       HSA: 4898(NRD1)
MOTIF       PS: PS00143  G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-
                         [LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.61
            ExPASy - ENZYME nomenclature database: 3.4.24.61
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.61
            BRENDA, the Enzyme Database: 3.4.24.61
///
ENTRY       EC 3.4.24.62
NAME        Magnolysin
            Neurosecretory granule protease cleaving Pro-Ocytocin/Neurophysin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to
            hydrolyse Pro-Ocytocin at Lys-Arg-|-Ala-Val. The specificity
            further depends on the organization of a beta-turn-alpha-helix of
            nine or more residues containing the paired basic amino acids near
            the center.
COMMENT     Inhibited by EDTA.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.62
            ExPASy - ENZYME nomenclature database: 3.4.24.62
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.62
            BRENDA, the Enzyme Database: 3.4.24.62
///
ENTRY       EC 3.4.24.63
NAME        Neprin B
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of proteins, including Azocasein, and Peptides.
            Hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 and
            19-Cys-|-Gly-20 bonds in Insulin B chain.
COMMENT     Meprin B is inhibited by EDTA and 1,10-Phenanthroline, but not by
            Phosphoramidon, Captopril or Thiorphan.
            Belongs to peptidase family M12A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.63
            ExPASy - ENZYME nomenclature database: 3.4.24.63
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.63
            BRENDA, the Enzyme Database: 3.4.24.63
///
ENTRY       EC 3.4.24.64
NAME        Mitochondrial processing peptidase
            Processing enhancing peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Release of N-terminal transit peptides from precursor proteins
            imported into the Mitochondrion, typically with Arg in position P2.
COFACTOR    Zinc
COMMENT     Known from the mitochondrial matrix of fungi and mammals.
            Belongs to peptidase family M16.
GENES       SYN: sll0055
            AAE: aq_1271(mpp)
            SCE: YHR024C(MAS2) YLR163C(MAS1)
            SPO: SPBC18E5.12C SPBP23A10.15C(spbp23a10.15c)
            ATH: At1g51980(F5F19.4) At3g02090(F1C9.12)
            CEL: ZC410.2
            DME: CG3731 CG8728
            HSA: 9512(PMPCB)
MOTIF       PS: PS00143  G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-
                         [LMFAT]-x-[LFSTH]-x-[GSTAN]-[GST]
STRUCTURES  PDB: 1HR7  1HR6  1HR9  1HR8  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.64
            ExPASy - ENZYME nomenclature database: 3.4.24.64
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.64
            BRENDA, the Enzyme Database: 3.4.24.64
///
ENTRY       EC 3.4.24.65
NAME        Macrophage elastase
            Metalloelastase
            Matrix metalloproteinase 12
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of soluble and insoluble Elastin. specific cleavages are
            also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain
            of Insulin.
COMMENT     Belongs to peptidase family M10B.
GENES       MMU: 97005(Mmel)
            HSA: 4321(MMP12)
DISEASE     MIM: 601046  Matrix metalloproteinase 12 (macrophage elastase)
MOTIF       PS: PS00024  [LIFAT]-x(3)-W-x(2,3)-[PE]-x(2)-[LIVMFY]-[DENQS]-[STA]-
                         [AV]-[LIVMFY]
            PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00546  P-R-C-[GN]-x-P-[DR]-[LIVSAPKQ]
STRUCTURES  PDB: 1JK3  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.65
            ExPASy - ENZYME nomenclature database: 3.4.24.65
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.65
            BRENDA, the Enzyme Database: 3.4.24.65
///
ENTRY       EC 3.4.24.66
NAME        Choriolysin L
            Teleost hatching enzyme
            Low choriolytic enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of the inner layer of fish egg envelope. Also hydrolyses
            Casein and small molecule substrates such as Suc-Leu-Leu-Val-Tyr-|-
            $Mca.
COMMENT     Belongs to peptidase family M12A.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.66
            ExPASy - ENZYME nomenclature database: 3.4.24.66
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.66
            BRENDA, the Enzyme Database: 3.4.24.66
///
ENTRY       EC 3.4.24.67
NAME        Choriolysin H
            Teleost hatching enzyme
            High choriolytic enzyme
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of the inner layer of fish egg envelope. Also hydrolyses
            Casein and small molecule substrates such as Suc-Leu-Leu-Val-Tyr-|-
            $Mca.
COMMENT     Belongs to peptidase family M12A.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.67
            ExPASy - ENZYME nomenclature database: 3.4.24.67
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.67
            BRENDA, the Enzyme Database: 3.4.24.67
///
ENTRY       EC 3.4.24.68
NAME        Tentoxylysin
            Tetanus neurotoxin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of 76-Gln-|-Phe-77 bond in Synaptobrevin 2.
COMMENT     Belongs to peptidase family M27.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1FV2  1DFQ  1AF9  1DLL  1DIW  1A8D  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.68
            ExPASy - ENZYME nomenclature database: 3.4.24.68
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.68
            BRENDA, the Enzyme Database: 3.4.24.68
            SCOP (Structural Classification of Proteins): 3.4.24.68
///
ENTRY       EC 3.4.24.69
NAME        Bontoxilysin
            Botulinum neurotoxin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Limited hydrolysis of proteins of the Neuroexocytosis apparatus,
            Synaptobravins, Snap250R syntaxin. No dected action on small
            molecule substrates.
COMMENT     Belongs to peptidase family M27.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
STRUCTURES  PDB: 1F82  1F83  1FQH  3BTA  1EPW  1F31  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.69
            ExPASy - ENZYME nomenclature database: 3.4.24.69
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.69
            BRENDA, the Enzyme Database: 3.4.24.69
            SCOP (Structural Classification of Proteins): 3.4.24.69
///
ENTRY       EC 3.4.24.70
NAME        Oligopeptidase A
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of Oligopeptides, with broad specificity. Gly or Ala
            commonly occur as P1 or P1' presidues, but more distant residues are
            also important. As is shown by the fact that Z-Gly-Pro-Gly-|-Gly-
            $Pro-Ala is cleaved, but not Z-(Gly)5.
COMMENT     Differs from thimet Oligopeptidase in lack of thiol activation.
            Belongs to peptidase family M3.
GENES       ECO: b3498(prlC)
            ECE: Z4898(prlC)
            YPE: YPO3975(opdA)
            HIN: HI0214(prlC)
            PMU: PM0680(prlC)
            XFA: XF0127
            VCH: VC0188
            PAE: PA0067(prlC)
            NME: NMB0214
            NMA: NMA0054(prlC)
            SYN: slr0659(prlC)
            DRA: DR1659
            DME: CG11771
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.70
            ExPASy - ENZYME nomenclature database: 3.4.24.70
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.70
            BRENDA, the Enzyme Database: 3.4.24.70
///
ENTRY       EC 3.4.24.71
NAME        Endothelin-converting enzyme 1
            ECE-1
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Forms Endothelin 1 by cleavage of the 21-Trp-|-Val-22 bond in the
            precursor.
COMMENT     Phosphoramidon-sensitive.
            Belongs to peptidase family M13.
GENES       DME: CG9565
            HSA: 1889(ECE1) 9718(KIAA0604)
DISEASE     MIM: 600423  Endothelin converting enzyme 1
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.71
            ExPASy - ENZYME nomenclature database: 3.4.24.71
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.71
            BRENDA, the Enzyme Database: 3.4.24.71
///
ENTRY       EC 3.4.24.72
NAME        Fibrolase
            Fibrinolytic proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of 14-Ala-|-Leu-15 in Insulin B chain and cleavage of
            413-Lys-|-Leu-414 in alpha chain of Fibrinogen.
COMMENT     Belongs to peptidase family M12.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.72
            ExPASy - ENZYME nomenclature database: 3.4.24.72
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.72
            BRENDA, the Enzyme Database: 3.4.24.72
///
ENTRY       EC 3.4.24.73
NAME        Jararhagin
            HF2-proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Cleavage of 10-His-|-Leu-11, 14-Ala-|-Leu-15, 16-Tyr-|-Leu-17 and
            24-Phe-|-Phe bonds in Insulin B chain.
COMMENT     Hemorrhagic Endopeptidase from the vemon of the Jararaca snake.
            Belongs to peptidase family M12.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
            PS: PS00427  C-x(2)-G-x-C-C-x-[NQRS]-C-x-[FM]-x(6)-C-[RK]
STRUCTURES  PDB: 1C9G  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.73
            ExPASy - ENZYME nomenclature database: 3.4.24.73
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.73
            BRENDA, the Enzyme Database: 3.4.24.73
            SCOP (Structural Classification of Proteins): 3.4.24.73
///
ENTRY       EC 3.4.24.74
NAME        Fragilysin
NAME        Bacteroides fragilis enterotoxin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Broad proteolytic specificity, bonds hydrolysed includes
            -gly-|-leu-, -met-|-leu-, -cys-|-leu-, -leu-|-gly-
COFACTOR    Zinc
COMMENT     Thought to be a cause of diarrhea.
            Hydrolyses extracellular matrix proteins, and disrupts tight
            junctions of intstinal cells. Also degrades intracellular,
            cytoskeletal proteins actin, myosin and others.
            Belongs to peptidase family M10.
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.74
            ExPASy - ENZYME nomenclature database: 3.4.24.74
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.74
///
ENTRY       EC 3.4.24.75
NAME        Lysostaphin
            Glycyl-glycine endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Metalloendopeptidases
REACTION    Hydrolysis of the -gly-|-gly- bond in the pentaglycine
            inter-peptide link joining staphylococcal cell wall peptidoglycans
COFACTOR    Zinc
COMMENT     Lyses cells of S.aureus in particular, by its action on the cross-
            bridge of the cell wall.
            Belongs to peptidase family M37.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.24.75
            ExPASy - ENZYME nomenclature database: 3.4.24.75
            WIT (What Is There) Metabolic Reconstruction: 3.4.24.75
///
ENTRY       EC 3.4.99.1
NAME        Transferred to EC 3.4.23.28
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.23.28 - Acrocylindropepsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.1
            ExPASy - ENZYME nomenclature database: 3.4.99.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.1
///
ENTRY       EC 3.4.99.2
NAME        Deleted entry
            Agavain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.2
            ExPASy - ENZYME nomenclature database: 3.4.99.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.2
///
ENTRY       EC 3.4.99.3
NAME        Deleted entry
            Angiotensinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.3
            ExPASy - ENZYME nomenclature database: 3.4.99.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.3
///
ENTRY       EC 3.4.99.4
NAME        Transferred to EC 3.4.23.12
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.23.12 - Nepenthesin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.4
            ExPASy - ENZYME nomenclature database: 3.4.99.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.4
///
ENTRY       EC 3.4.99.5
NAME        Transferred to EC 3.4.24.3
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.3 - Microbial collagenase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.5
            ExPASy - ENZYME nomenclature database: 3.4.99.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.5
///
ENTRY       EC 3.4.99.6
NAME        Transferred to EC 3.4.24.21
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.21 - Astacin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.6
            ExPASy - ENZYME nomenclature database: 3.4.99.6
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.6
///
ENTRY       EC 3.4.99.7
NAME        Deleted entry
            Euphorbain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.7
            ExPASy - ENZYME nomenclature database: 3.4.99.7
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.7
///
ENTRY       EC 3.4.99.8
NAME        Deleted entry
            Gliocladium proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.8
            ExPASy - ENZYME nomenclature database: 3.4.99.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.8
            BRENDA, the Enzyme Database: 3.4.99.8
///
ENTRY       EC 3.4.99.9
NAME        Deleted entry
            Hurain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.9
            ExPASy - ENZYME nomenclature database: 3.4.99.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.9
///
ENTRY       EC 3.4.99.10
NAME        Transferred to EC 3.4.24.56
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.56 - Insulinase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.10
            ExPASy - ENZYME nomenclature database: 3.4.99.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.10
///
ENTRY       EC 3.4.99.11
NAME        Deleted entry
            Streptomyces alkalophilic keratinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.11
            ExPASy - ENZYME nomenclature database: 3.4.99.11
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.11
///
ENTRY       EC 3.4.99.12
NAME        Deleted entry
            Trichophyton mentagrophytes keratinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.12
            ExPASy - ENZYME nomenclature database: 3.4.99.12
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.12
///
ENTRY       EC 3.4.99.13
NAME        Transferred to EC 3.4.24.32
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.32 - beta-Lytic
            metalloendopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.13
            ExPASy - ENZYME nomenclature database: 3.4.99.13
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.13
///
ENTRY       EC 3.4.99.14
NAME        Deleted entry
            Mexicanain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.14
            ExPASy - ENZYME nomenclature database: 3.4.99.14
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.14
///
ENTRY       EC 3.4.99.15
NAME        Deleted entry
            Paecilomyces proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.15
            ExPASy - ENZYME nomenclature database: 3.4.99.15
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.15
///
ENTRY       EC 3.4.99.16
NAME        Deleted entry
            Penicillium notatum extracellular proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.16
            ExPASy - ENZYME nomenclature database: 3.4.99.16
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.16
///
ENTRY       EC 3.4.99.17
NAME        Deleted entry
            Peptidoglycan endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.17
            ExPASy - ENZYME nomenclature database: 3.4.99.17
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.17
///
ENTRY       EC 3.4.99.18
NAME        Deleted entry
            Pinguinain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.18
            ExPASy - ENZYME nomenclature database: 3.4.99.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.18
///
ENTRY       EC 3.4.99.19
NAME        Transferred to EC 3.4.23.15
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.23.15 - Renin.
GENES       MMU: 97898(Ren1) 97899(Ren2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.19
            ExPASy - ENZYME nomenclature database: 3.4.99.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.19
///
ENTRY       EC 3.4.99.20
NAME        Deleted entry
            Scopulariopsis proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.20
            ExPASy - ENZYME nomenclature database: 3.4.99.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.20
///
ENTRY       EC 3.4.99.21
NAME        Deleted entry
            Solanain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.21
            ExPASy - ENZYME nomenclature database: 3.4.99.21
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.21
///
ENTRY       EC 3.4.99.22
NAME        Transferred to EC 3.4.24.29
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.29 - Aureolysin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.22
            ExPASy - ENZYME nomenclature database: 3.4.99.22
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.22
///
ENTRY       EC 3.4.99.23
NAME        Deleted entry
            Tabernamontanain
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.23
            ExPASy - ENZYME nomenclature database: 3.4.99.23
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.23
///
ENTRY       EC 3.4.99.24
NAME        Deleted entry
            Tenebrio alpha-proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.24
            ExPASy - ENZYME nomenclature database: 3.4.99.24
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.24
///
ENTRY       EC 3.4.99.25
NAME        Transferred to EC 3.4.23.21
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included with EC 3.4.23.21 - Rhizopepsin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.25
            ExPASy - ENZYME nomenclature database: 3.4.99.25
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.25
///
ENTRY       EC 3.4.99.26
NAME        Transferred to EC 3.4.21.73 and 3.4.21.68
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.21.73 - u-Plasminogen activator and
            EC 3.4.21.68 - t-Plasminogen activator.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.26
            ExPASy - ENZYME nomenclature database: 3.4.99.26
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.26
///
ENTRY       EC 3.4.99.27
NAME        Deleted entry
            Echis carinatus prothrombin-activating proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.27
            ExPASy - ENZYME nomenclature database: 3.4.99.27
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.27
///
ENTRY       EC 3.4.99.28
NAME        Transferred to EC 3.4.21.60
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.21.60 - Scutelarin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.28
            ExPASy - ENZYME nomenclature database: 3.4.99.28
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.28
///
ENTRY       EC 3.4.99.29
NAME        Deleted entry
            Myxobacter AL-1 proteinase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.29
            ExPASy - ENZYME nomenclature database: 3.4.99.29
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.29
///
ENTRY       EC 3.4.99.30
NAME        Transferred to EC 3.4.24.20
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.24.20 - Peptidyl-Lys
            metalloendopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.30
            ExPASy - ENZYME nomenclature database: 3.4.99.30
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.30
///
ENTRY       EC 3.4.99.31
NAME        Transferred to EC 3.4.24.15
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included with EC 3.4.24.15 - Thimet
            oligopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.31
            ExPASy - ENZYME nomenclature database: 3.4.99.31
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.31
            BRENDA, the Enzyme Database: 3.4.99.31
///
ENTRY       EC 3.4.99.32
NAME        Transferred to EC 3.4.24.20
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.24.20 - Peptidyl-Lys
            metalloendopeptidase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.32
            ExPASy - ENZYME nomenclature database: 3.4.99.32
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.32
///
ENTRY       EC 3.4.99.33
NAME        Deleted entry
            Cathepsin R
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.33
            ExPASy - ENZYME nomenclature database: 3.4.99.33
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.33
///
ENTRY       EC 3.4.99.34
NAME        Deleted entry
            Mytilidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.34
            ExPASy - ENZYME nomenclature database: 3.4.99.34
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.34
///
ENTRY       EC 3.4.99.35
NAME        Transferred to EC 3.4.23.36
            Premurein-leader peptidase
            Prolipoprotein signal peptidase
            Signal peptidase II
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.23.36 - Signal peptidase
            II.  A 36 kDa enzyme present on the inner membrane of E. coli.
            Residue Cys21 in the substrate is alkylated on sulfur with the
            R-COOCH2-CH(OCO-R)-CH2- group.  The enzyme is inhibited by the
            antibiotic globomycin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.35
            ExPASy - ENZYME nomenclature database: 3.4.99.35
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.35
///
ENTRY       EC 3.4.99.36
NAME        Transferred to EC 3.4.21.89
            Leader peptidase
            Signal peptidase I
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.21.89 - Signal peptidase
            I.  A 36 kDa enzyme in the inner and outer membranes of E. coli.
            Not inhibited by phenylmethylsulfonyl fluoride or 1,10-
            phenanthroline.  Cleaves a single bond Ala-|-Ala in M13 phage
            procoat protein, so producing free leader (signal) peptide and coat
            protein. Also accurately cleaves a 16-residue synthetic peptide
            that spans the normal cleavage site. The characteristics of the P1
            and P3 residues are especially important in the specificity of
            leader peptidase.  Leader peptidases that may have somewhat
            different specificities are known eukaryotic organisms also.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.36
            ExPASy - ENZYME nomenclature database: 3.4.99.36
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.36
///
ENTRY       EC 3.4.99.37
NAME        Deleted entry
            RecA peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
STRUCTURES  PDB: 1G18  1G19  1REA  2REB  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.37
            ExPASy - ENZYME nomenclature database: 3.4.99.37
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.37
            SCOP (Structural Classification of Proteins): 3.4.99.37
///
ENTRY       EC 3.4.99.38
NAME        Transferred to EC 3.4.23.17
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now EC 3.4.23.17 - Pro-opiomelanocortin
            converting enzyme.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.38
            ExPASy - ENZYME nomenclature database: 3.4.99.38
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.38
///
ENTRY       EC 3.4.99.39
NAME        Deleted entry
            Pseudomurein endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.39
            ExPASy - ENZYME nomenclature database: 3.4.99.39
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.39
///
ENTRY       EC 3.4.99.40
NAME        Deleted entry
            Pro-gonadoliberin proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.40
            ExPASy - ENZYME nomenclature database: 3.4.99.40
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.40
///
ENTRY       EC 3.4.99.41
NAME        Transferred to EC 3.4.24.64
            Mitochondrial processing peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.24.64 - Mitochondrial
            Processing peptidase.  Known from the mitochondrial matrix of fungi
            and mammals.  A homologue of insulinase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.41
            ExPASy - ENZYME nomenclature database: 3.4.99.41
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.41
///
ENTRY       EC 3.4.99.42
NAME        Deleted entry
            Leucyllysine endopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.42
            ExPASy - ENZYME nomenclature database: 3.4.99.42
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.42
///
ENTRY       EC 3.4.99.43
NAME        Thermopsin
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
REACTION    Specificity similar to pepsin A, prefers bulky hydrophobic
            side-chains on either side of scissile bond
SUBSTRATE   Protein
PRODUCT     Protein
INHIBITOR   Pepstatin
COMMENT     Isolated from cells and culture medium of the thermophilic
            archebacterium Sulfolobus acidocaldarius, optimum digestion at pH
            2 and 90 C, no sequence homology to known aspartic endopeptidases,
            but inhibited by pepstatin. Another thermostable bacterial
            endopeptidase has been isolated from Bacillus sp., but this is not
            inhibited by pepstatin.
GENES       SSO: SSO1886 SSO2037 SSO2194
            STO: ST0894
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.43
            ExPASy - ENZYME nomenclature database: 3.4.99.43
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.43
            BRENDA, the Enzyme Database: 3.4.99.43
///
ENTRY       EC 3.4.99.44
NAME        Transferred to EC 3.4.24.55
            Pitrilysin
            E. coli protease
            Protease Pi
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.24.55 - Pitrilysin.
            A homologue of insulinase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.44
            ExPASy - ENZYME nomenclature database: 3.4.99.44
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.44
///
ENTRY       EC 3.4.99.45
NAME        Transferred to EC 3.4.24.56
            Insulinase
            Insulin-degrading enzyme
            Insulin protease
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
COMMENT     Transferred entry. Now included in EC 3.4.24.56 - Insulysin.
            Homologue of pitrilysin. Formerly EC 3.4.22.11 and 3.4.99.10.
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.45
            ExPASy - ENZYME nomenclature database: 3.4.99.45
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.45
///
ENTRY       EC 3.4.99.46
NAME        Multicatalytic endopeptidase complex
            Multicatalytic proteinase (complex)
            Ingensin
            Macropain
            Prosome
            Proteasome
            a component of Lens neutral proteinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Endopeptidases of unknown catalytic mechanism
REACTION    Cleavage at Xaa+ bonds in which Xaa carries a hydrophobic, basic
            or acidic sidechain
SUBSTRATE   Protein
            Peptide
            H2O
PRODUCT     Protein
            Peptide
INHIBITOR   Mercurial reagent
            Inhibitor of serine endopeptidase
COMMENT     A multisubunit protein abundant in the cytoplasm of most
            eukaryotic cells, apparently containing at least three distinct
            endopeptidase active sites. Inhibited by mercurial reagents and
            some inhibitors of serine endopeptidases.  Formerly included in
            EC 3.4.24.5 and 3.4.22.21.
PATHWAY     PATH: MAP03050  Proteasome
GENES       MTU: Rv2109c(prcA) Rv2110c(prcB)
            MTC: MT2169
            MLE: ML1322(prcB)
            MJA: MJ0591 MJ1237
            MTH: MTH1202 MTH686
            AFU: AF0481(psmB) AF0490(psmA)
            HAL: VNG0166G(psmB) VNG0880G(psmA)
            TAC: Ta0612 Ta1288
            TVO: TVG0317752 TVG0656650
            PHO: PH0245 PH1402 PH1553
            PAB: PAB0417(psmA) PAB1867 PAB2199(psmB)
            APE: APE0507 APE0521 APE1449
            SSO: SSO0278 SSO0738 SSO0766
            STO: ST0324 ST0446 ST0477
            SCE: YBL041W(PRE7) YER012W(PRE1) YER094C(PUP3) YFR050C(PRE4)
                 YGL011C(SCL1) YGR135W(PRE9) YGR253C(PUP2) YJL001W(PRE3)
                 YML092C(PRE8) YMR314W(PRE5) YOL038W(PRE6) YOR157C(PUP1)
                 YOR362C(PRE10) YPR103W(PRE2)
            SPO: PTS1(pts1) SPAC13C5.01C SPAC22D3.07(spac22d3.07)
                 SPAC22F8.06(spac22f8.06) SPAC31A2.04C(spac31a2.04c)
                 SPAC323.02C(spac323.02c) SPAC6G10.04C(spac6g10.04c)
                 SPBC106.16(spbc106.16) SPBC4C3.10C(spbc4c3.10c)
                 SPBC577.10(spbc577.10) SPBC646.16(spbc646.16)
                 SPCC1442.06(spcc1442.06) SPCC1795.04C(spcc1795.04c)
                 SPCC63.12C(spcc63.12c)
            ATH: At1g13060(F3F19.8) At1g16470(F3O9.27) At1g21720(F8K7.15)
                 At1g53850(T18A20.8) At1g79210(YUP8H12R.19) At2g05840(T6P5.4)
                 At2g27020(T20P8.7) At4g14800(dl3440w) At4g31300(F8F16.120)
            CEL: C02F5.9 C15H11.7 C36B1.4 C47B2.4 CD4.6 D1054.2 F25H2.9
                 F39H11.5 K05C4.1 T20F5.2 Y38A8.2 ZK945.2
            DME: CG10938(ProsMA5) CG11981(Prosbeta3) CG12000 CG12323
                 CG1519(Prosalpha7) CG17268(Pros28.1A) CG17301 CG17302 CG17331
                 CG1736 CG18341 CG3329(Prosbeta2) CG3422(Pros28.1)
                 CG4097(Pros26) CG4569(Pros28.1B) CG4904(Pros35) CG5266(Pros25)
                 CG5648 CG8392 CG9327(Pros29) CG9868
            MMU: 104885(Psma2) 96797(Lmp2)
            HSA: 5682(PSMA1) 5683(PSMA2) 5684(PSMA3) 5685(PSMA4) 5686(PSMA5)
                 5687(PSMA6) 5688(PSMA7) 5689(PSMB1) 5690(PSMB2) 5691(PSMB3)
                 5692(PSMB4) 5693(PSMB5) 5694(PSMB6) 5695(PSMB7) 5696(PSMB8)
                 5698(PSMB9) 5699(PSMB10)
DISEASE     MIM: 176842  Proteasome (prosome, macropain) subunit, alpha type, 2
            MIM: 176843  Proteasome (prosome, macropain) subunit, alpha type, 3
            MIM: 176844  Proteasome component 5
            MIM: 177045  Proteasome subunit, beta type, 9
            MIM: 177046  Proteasome subunit, beta type, 8 (large
                         multifunctional protease-7)
            MIM: 600306  Proteasome subunit, beta type, 5
MOTIF       PS: PS00388  [FY]-x(4)-[STNLV]-x-[FYW]-S-P-x-G-[RKHDS]-x(2)-Q-
                         [LIVA]-[DEN]-[YH]-[GSAD]-x(2)-[GSAG]
            PS: PS00854  [LIVMA]-[GSA]-[LIVMF]-x-[FYLVGAC]-x(2)-[GSACFY]-
                         [LIVMSTAC](2)-[LIVMFSTAC]-[GAC]-[GSTACV]-[DES]-x(15)-
                         [RK]-x(12,13)-G-x(2)-[GSTA]-D
STRUCTURES  PDB: 1RYP  1FNT  1G0U  1G65  1PMA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.4.99.46
            ExPASy - ENZYME nomenclature database: 3.4.99.46
            WIT (What Is There) Metabolic Reconstruction: 3.4.99.46
            BRENDA, the Enzyme Database: 3.4.99.46
            SCOP (Structural Classification of Proteins): 3.4.99.46
///
ENTRY       EC 3.5.1.1
NAME        Asparaginase
            Asparaginase II
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Asparagine amidohydrolase
REACTION    L-Asparagine + H2O = L-Aspartate + NH3
SUBSTRATE   L-Asparagine
            H2O
PRODUCT     L-Aspartate
            NH3
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0828(ybiK) b1767(ansA) b2957(ansB)
            ECE: Z1051 Z1052 Z2801(ansA) Z4302(ansB)
            ECS: ECs0906 ECs0907 ECs2474 ECs3833
            YPE: YPO1386(ansB) YPO2161(ansA)
            HIN: HI0745(ansB)
            VCH: VC1995 VC2603
            PAE: PA1337(ansB) PA2253(ansA)
            NME: NMB1688
            NMA: NMA1947(ans)
            HPY: HP0723(ansB)
            HPJ: jhp0661
            CJE: Cj0029(ansA)
            CCR: CC0097 CC0576
            BSU: BG10300(ansA) BG12755(yccC)
            BHA: BH1624
            SAU: SA1310(ansA)
            SAV: SAV1468(ansA)
            LLA: L142722(ansB)
            SPY: SPy1782(asnB)
            SPN: SP1998
            SPR: spr1812(ansB)
            CAC: CAC1714(ansA)
            MTU: Rv1538c(ansA)
            MTC: MT1590
            MLE: ML1198(ansA)
            SYN: sll0422
            DRA: DR2353
            MJA: MJ0020
            MTH: MTH706
            AFU: AF0882(asnA)
            HAL: VNG1844G(ansA) VNG1872C
            TAC: Ta0338 Ta0972
            TVO: TVG0422264 TVG1168744
            PHO: PH0066 PH0232 PH1463
            PAB: PAB0145(asnA-2) PAB1901(asnA) PAB2294
            APE: APE2200
            SSO: SSO0938(ansA) SSO2350(ansA-like)
            STO: ST1264
            SCE: YDR321W(ASP1) YLR155C(ASP3-1) YLR157C(ASP3-2) YLR158C(ASP3-3)
                 YLR160C(ASP3-4)
            SPO: SPAC186.03(spac186.03)
            CEL: C27A7.5a
            DME: CG7860
MOTIF       PS: PS00144  [LIVM]-x(2)-T-G-G-T-[IV]-[AGS]
            PS: PS00917  G-x-[LIVM]-x(2)-H-G-T-D-T-[LIVM]
STRUCTURES  PDB: 1AGX  1HFJ  1HFK  1HFW  1HG0  1HG1  1HO3  1WSA  3ECA  3PGA  
                 4ECA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.1
            ExPASy - ENZYME nomenclature database: 3.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.1
            BRENDA, the Enzyme Database: 3.5.1.1
            SCOP (Structural Classification of Proteins): 3.5.1.1
///
ENTRY       EC 3.5.1.2
NAME        Glutaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Glutamineamidohydrolase
REACTION    L-Glutamine + H2O = L-Glutamate + NH3
SUBSTRATE   L-Glutamine
            H2O
PRODUCT     L-Glutamate
            NH3
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0485(ybaS) b1524(yneH)
            ECE: Z0606(ybaS) Z2179(yneH)
            ECS: ECs0538 ECs2131
            YPE: YPO1939
            VCH: VC0454
            PAE: PA1638
            MLO: mlr0211
            CCR: CC0276
            BSU: BG12753(ybgJ) BG13350(ylaM)
            BHA: BH2627 BH2717
            SYN: slr2079
            CEL: DH11.1 F30F8.2
            HSA: 27165 2744(GLS)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.2
            ExPASy - ENZYME nomenclature database: 3.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.2
            BRENDA, the Enzyme Database: 3.5.1.2
///
ENTRY       EC 3.5.1.3
NAME        omega-Amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     omega-Amidodicarboxylate amidohydrolase
REACTION    a Monoamide of a dicarboxylic acid + H2O = a Dicarboxylate + NH3
SUBSTRATE   Monoamide of a dicarboxylic acid
            H2O
PRODUCT     Dicarboxylate
            NH3
COMMENT     Acts on glutaramate, succinamate and their 2-oxo derivatives.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.3
            ExPASy - ENZYME nomenclature database: 3.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.3
            BRENDA, the Enzyme Database: 3.5.1.3
///
ENTRY       EC 3.5.1.4
NAME        Amidase
            Acylamidase
            Acylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Acylamide aminohydrolase
REACTION    a Monocarboxylic acid amide + H2O = a Monocarboxylate + NH3
SUBSTRATE   Monocarboxylic acid amide
            H2O
PRODUCT     Monocarboxylate
            NH3
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00643  Styrene degradation
GENES       PAE: PA0202 PA0704 PA3366(amiE) PA4342
            HPY: HP0294(aimE) HP1238(aimE)
            HPJ: jhp0279 jhp0769 jhp1159
            MLO: mlr5350
            SME: SMc03245
            MGE: MG099
            MPN: G07_orf478V
            MTU: Rv1263(amiB2) Rv2363(amiA2) Rv2888c(amiC) Rv3175 Rv3375(amiD)
            MTC: MT1301 MT2432 MT2956 MT3264 MT3485
            MLE: ML1596
            SYN: sll0828(nylA)
            DRA: DR1377 DR1625
            MJA: MJ1160
            MTH: MTH1496
            APE: APE0979
            SCE: YDR242W(AMD2) YMR293C(YMR293C)
            SPO: SPAC869.01(spac869.01)
            CEL: B0218.1 B0218.2
MOTIF       PS: PS00571  G-[GA]-S-[GS]-[GS]-G-x-[GSA]-[GSAVY]-x-[LIVM]-[GSA]-
                         x(6)-[GSAT]-x-[GA]-x-[DE]-x-[GA]-x-S-[LIVM]-R-x-P-
                         [GSAC]
STRUCTURES  PDB: 1K17  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.4
            ExPASy - ENZYME nomenclature database: 3.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.4
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.4
            BRENDA, the Enzyme Database: 3.5.1.4
///
ENTRY       EC 3.5.1.5
NAME        Urease
            Urea amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Urea amidohydrolase
REACTION    Urea + H2O = CO2 + 2 NH3
SUBSTRATE   Urea
            H2O
PRODUCT     CO2
            NH3
COFACTOR    Nickel
COMMENT     A nickel protein.  The epsilon-amino residue of Lys is modified
            by reaction with carbon monooxide to form a carbamate group.
            Carbon oxide is required for nickel binding to metal-free urease.
            Two nickel ions bind to ureaase.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00230  Purine metabolism
GENES       ECE: Z1143(ureA) Z1144(ureB) Z1145(ureC) Z1582(ureA_2)
                 Z1583(ureB_2) Z1584(ureC_2)
            ECS: ECs1322 ECs1323 ECs1324
            YPE: YPO2665(ureA) YPO2666(ureB) YPO2667(ureC)
            HIN: HI0539(ureC) HI0540(ureB) HI0541(ureA)
            PAE: PA4865(ureA) PA4867(ureB) PA4868(ureC)
            HPY: HP0072(ureB) HP0073(ureA)
            HPJ: jhp0067 jhp0068
            MLO: mll4940 mll4948 msl4944
            SME: SMc01837(ureC) SMc01939(ureB) SMc01941(ureA)
            BSU: BG11981(ureA) BG11982(ureB) BG11983(ureC)
            BHA: BH0252(ureA) BH0253(ureB) BH0254(ureC)
            SAU: SA2082(ureA) SA2083(ureB) SA2084(ureC)
            SAV: SAV2273(ureA) SAV2274(ureB) SAV2275(ureC)
            UUR: UU432(ureC) UU433(ureB) UU434(ureA)
            MTU: Rv1848(ureA) Rv1849(ureB) Rv1850(ureC)
            MTC: MT1896 MT1897 MT1898
            SYN: sll0420(ureB) sll1750(ureC) slr1256(ureA)
            DRA: DRA0318 DRA0319
            STO: ST1028 ST1029
            SPO: URE1(ure1)
            ATH: At1g67550(F12B7.10)
MOTIF       PS: PS00145  [LIVM](2)-[CT]-H-[HN]-L-x(3)-[LIVM]-x(2)-D-[LIVM]-x-F-A
            PS: PS01120  T-[AY]-[GA]-[GAT]-[LIVM]-D-x-H-[LIVM]-H-x(3)-P
STRUCTURES  PDB: 4UBP  3UBP  1FWJ  1FWI  1A5K  1A5L  1A5M  1A5N  1A5O  1EF2  
                 1EJR  1EJS  1EJT  1EJU  1EJV  1FWA  2UBP  2KAU  1UBP  1KRC  
                 1KRB  1KRA  1IE7  1FWB  1FWH  1FWG  1FWF  1FWE  1FWD  1FWC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.5
            ExPASy - ENZYME nomenclature database: 3.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.5
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.5
            BRENDA, the Enzyme Database: 3.5.1.5
            SCOP (Structural Classification of Proteins): 3.5.1.5
///
ENTRY       EC 3.5.1.6
NAME        beta-Ureidopropionase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Carbamoyl-beta-alanine amidohydrolase
REACTION    N-Carbamoyl-beta-alanine + H2O = beta-Alanine + CO2 + NH3
SUBSTRATE   N-Carbamoyl-beta-alanine
            3-Ureidoisobutyrate
            H2O
PRODUCT     beta-Alanine
            3-Aminoisobutanoate
            CO2
            NH3
COMMENT     The animal enzyme also acts on beta-ureidoisobutyrate.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       PAE: PA0444
            MLO: mll1631
            SPR: spr0823(but)
            ATH: At5g64370(MSJ1.21)
            CEL: F13H8.7
            DME: CG3027
            HSA: 51733(LOC51733)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.6
            ExPASy - ENZYME nomenclature database: 3.5.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.6
            BRENDA, the Enzyme Database: 3.5.1.6
///
ENTRY       EC 3.5.1.7
NAME        Ureidosuccinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Carbamoyl-L-aspartate amidohydrolase
REACTION    N-Carbamoyl-L-aspartate + H2O = L-Aspartate + CO2 + NH3
SUBSTRATE   N-Carbamoyl-L-aspartate
            H2O
PRODUCT     L-Aspartate
            CO2
            NH3
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.7
            ExPASy - ENZYME nomenclature database: 3.5.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.7
            BRENDA, the Enzyme Database: 3.5.1.7
///
ENTRY       EC 3.5.1.8
NAME        Formylaspartate deformylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Formyl-L-aspartate amidohydrolase
REACTION    N-Formyl-L-aspartate + H2O = Formate + L-Aspartate
SUBSTRATE   N-Formyl-L-aspartate
            H2O
PRODUCT     Formate
            L-Aspartate
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.8
            ExPASy - ENZYME nomenclature database: 3.5.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.8
            BRENDA, the Enzyme Database: 3.5.1.8
///
ENTRY       EC 3.5.1.9
NAME        Arylformamidase
            Kynurenine formamidase
            Formylase
            Formylkynureninase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Aryl-formylamine amidohydrolase
REACTION    N-Formyl-L-kynurenine + H2O = Formate + L-Kynurenine
SUBSTRATE   N-Formyl-L-kynurenine
            H2O
PRODUCT     Formate
            L-Kynurenine
COMMENT     Also acts on other aromatic formylamines.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.9
            ExPASy - ENZYME nomenclature database: 3.5.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.9
            BRENDA, the Enzyme Database: 3.5.1.9
///
ENTRY       EC 3.5.1.10
NAME        Formyltetrahydrofolate deformylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     10-Formyltetrahydrofolate amidohydrolase
REACTION    10-Formyltetrahydrofolate + H2O = Formate + Tetrahydrofolate
SUBSTRATE   10-Formyltetrahydrofolate
            H2O
PRODUCT     Formate
            Tetrahydrofolate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b1232(purU)
            ECE: Z2008(purU)
            ECS: ECs1734
            YPE: YPO2171(purU)
            HIN: HI1588(purU)
            PMU: PM0873(purU)
            XFA: XF1831
            VCH: VC1992
            PAE: PA4314(purU1) PA5420(purU2)
            HPY: HP1434(purU)
            HPJ: jhp1327
            CJE: Cj0790(purU)
            SME: SMa2141 SMc03205(purU1) SMc04154(purU2)
            CCR: CC3630
            BSU: BG13237(purU)
            BHA: BH3265
            MTU: Rv2964(purU)
            MTC: MT3041
            SYN: sll0070(purU)
            DRA: DR0584
            AAE: aq_1818(purU)
            HAL: VNG1946G(purU)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.10
            ExPASy - ENZYME nomenclature database: 3.5.1.10
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.10
            BRENDA, the Enzyme Database: 3.5.1.10
///
ENTRY       EC 3.5.1.11
NAME        Penicillin amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Penicillin amidohydrolase
REACTION    Penicillin + H2O = a Carboxylate + 6-Aminopenicillanate
SUBSTRATE   Penicillin
            H2O
PRODUCT     Carboxylate
            6-Aminopenicillanate
GENES       BSU: BG11885(yxeI)
            SAU: SA0264
            SAV: SAV0267
            LLA: L86424(pacB)
            SYN: slr1772
            SSO: SSO1460 SSO1638
STRUCTURES  PDB: 1AI6  1AI4  3PVA  1AI7  2PVA  1PNM  1PNL  1PNK  1FXV  1FXH  
                 1E3A  1CP9  1AJQ  1AJP  1AJN  1AI5  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.11
            ExPASy - ENZYME nomenclature database: 3.5.1.11
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.11
            BRENDA, the Enzyme Database: 3.5.1.11
            SCOP (Structural Classification of Proteins): 3.5.1.11
///
ENTRY       EC 3.5.1.12
NAME        Biotinidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Biotin-amide amidohydrolase
REACTION    Biotin amide + H2O = Biotin + NH3
SUBSTRATE   Biotin amide
            H2O
PRODUCT     Biotin
            NH3
COMMENT     Also acts on biotin esters.
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       HSA: 686(BTD)
DISEASE     MIM: 253260  Biotinidase
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.12
            ExPASy - ENZYME nomenclature database: 3.5.1.12
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.12
            BRENDA, the Enzyme Database: 3.5.1.12
///
ENTRY       EC 3.5.1.13
NAME        Aryl-acylamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Aryl-acylamide amidohydrolase
REACTION    an Anilide + H2O = a Carboxylate + Aniline
SUBSTRATE   Anilide
            H2O
            4-Substituted anilide
PRODUCT     Carboxylate
            Aniline
            4-Substituted aniline
COMMENT     Also acts on 4-substituted anilides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.13
            ExPASy - ENZYME nomenclature database: 3.5.1.13
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.13
            BRENDA, the Enzyme Database: 3.5.1.13
///
ENTRY       EC 3.5.1.14
NAME        Aminoacylase
            Dehydropeptidase II
            Histozyme
            Hippuricase
            Benzamidase
            Acylase I
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acyl-L-amino-acid amidohydrolase
REACTION    an N-Acyl-L-amino acid + H2O = a Carboxylate + an L-Amino acid
SUBSTRATE   N-Acyl-L-amino acid
            H2O
            Dehydropeptide
PRODUCT     Carboxylate
            L-Amino acid
COMMENT     Wide specificity; also hydrolyses dehydropeptides. Used in
            separating D- and L- amino acids.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       CEL: C06A6.4 C10C5.3 C10C5.4 C10C5.5
            DME: CG17110 CG6733
            MMU: 87913(Acy1)
            HSA: 95(ACY1)
DISEASE     MIM: 104620  Aminoacylase-1
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.14
            ExPASy - ENZYME nomenclature database: 3.5.1.14
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.14
            BRENDA, the Enzyme Database: 3.5.1.14
///
ENTRY       EC 3.5.1.15
NAME        Aspartoacylase
            Aminoacylase II
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acyl-L-aspartate amidohydrolase
REACTION    N-Acyl-L-aspartate + H2O = a Carboxylate + L-Aspartate
SUBSTRATE   N-Acyl-L-aspartate
            H2O
PRODUCT     Carboxylate
            L-Aspartate
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00340  Histidine metabolism
GENES       HSA: 443(ASPA)
DISEASE     MIM: 271900  Aspartoacylase (aminoacylase-2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.15
            ExPASy - ENZYME nomenclature database: 3.5.1.15
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.15
            BRENDA, the Enzyme Database: 3.5.1.15
///
ENTRY       EC 3.5.1.16
NAME        Acetylornithine deacetylase
            Acetylornithinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N2-Acetyl-L-ornithine amidohydrolase
REACTION    N2-Acetyl-L-ornithine + H2O = Acetate + L-Ornithine
SUBSTRATE   N2-Acetyl-L-ornithine
            H2O
            N-Acetylmethionine
PRODUCT     Acetate
            L-Ornithine
            L-Methionine
COMMENT     Also hydrosyses N-acetylmethionine
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       ECO: b3957(argE)
            ECE: Z5515(argE)
            ECS: ECs4886
            YPE: YPO3928(argE)
            PMU: PM1117(argE)
            XFA: XF1000
            VCH: VC2645
            PAE: PA5206(argE) PA5390
            BUC: BU047(argE)
            MLO: mll7049 mlr7167
            SME: SMa1836(argE)
            CCR: CC3631
            BSU: BG12569(argE)
            BHA: BH1059(argE)
            LLA: L0115(argE)
            MJA: MJ1497(argE)
            AFU: AF0522(argE)
            PHO: PH1153 PH1715
            PAB: PAB0294(argE) PAB0723(argE-like)
            APE: APE1467
            SSO: SSO0790(argE-1)
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.16
            ExPASy - ENZYME nomenclature database: 3.5.1.16
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.16
            BRENDA, the Enzyme Database: 3.5.1.16
///
ENTRY       EC 3.5.1.17
NAME        Acyl-lysine deacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N6-Acyl-L-lysine amidohydrolase
REACTION    N6-Acyl-L-lysine + H2O = a Carboxylate + L-Lysine
SUBSTRATE   N6-Acyl-L-lysine
            H2O
PRODUCT     Carboxylate
            L-Lysine
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.17
            ExPASy - ENZYME nomenclature database: 3.5.1.17
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.17
            BRENDA, the Enzyme Database: 3.5.1.17
///
ENTRY       EC 3.5.1.18
NAME        Succinyl-diaminopimelate desuccinylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
REACTION    N-Succinyl-LL-2,6-diaminoheptanedioate + H2O = Succinate +
            LL-2,6-Diaminoheptanedioate
SUBSTRATE   N-Succinyl-LL-2,6-diaminoheptanedioate
            H2O
PRODUCT     Succinate
            LL-2,6-Diaminoheptanedioate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b2472(dapE)
            ECE: Z3730(dapE)
            ECS: ECs3334
            YPE: YPO3053(dapE)
            HIN: HI0102(dapE)
            PMU: PM1022(dapE)
            XFA: XF0116
            VCH: VC2152
            PAE: PA1162(dapE)
            BUC: BU095(dapE)
            NME: NMB1530
            NMA: NMA1730(dapE)
            HPY: HP0212(dapE)
            HPJ: jhp0198
            CJE: Cj1048c(dapE)
            RPR: RP874(dapE)
            RCO: RC1347(dapE)
            MLO: mlr1185 mlr4849
            SME: SMc01096(dapE)
            CCR: CC0275
            BSU: BG13867(ytjP)
            BHA: BH3272
            SAU: SA1572
            SAV: SAV1737
            LLA: L59867(pepV)
            SPY: SPy1070
            SPN: SP0623
            SPR: spr0148(dapE) spr0547(pepV)
            CAC: CAC2723
            MTU: Rv1202(dapE)
            MTC: MT1240
            MLE: ML1059(dapE)
            DRA: DR1413
            AAE: aq_547(dapE)
            TMA: TM1666
            MJA: MJ0457
            AFU: AF0051(dapE-1) AF0904(dapE-2)
            TAC: Ta0934
            TVO: TVG1135544
            PHO: PH0265
            APE: APE0632 APE1917
            SSO: SSO1538(dapE)
MOTIF       PS: PS00758  [LIV]-[GALMY]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DNG]-E-E-x-[GSTN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.18
            ExPASy - ENZYME nomenclature database: 3.5.1.18
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.18
            BRENDA, the Enzyme Database: 3.5.1.18
///
ENTRY       EC 3.5.1.19
NAME        Nicotinamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Nicotinamide amidohydrolase
REACTION    Nicotinamide + H2O = Nicotinate + NH3
SUBSTRATE   Nicotinamide
            H2O
PRODUCT     Nicotinate
            NH3
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       YPE: YPO2160(pncA)
            NME: NMB2157
            NMA: NMA0244(pncA)
            BBU: BBE22(pncA)
            TPA: TP0696
            AAE: aq_994(pncA)
            TMA: TM0475
            PHO: PH0999
            PAB: PAB1720
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.19
            ExPASy - ENZYME nomenclature database: 3.5.1.19
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.19
            BRENDA, the Enzyme Database: 3.5.1.19
///
ENTRY       EC 3.5.1.20
NAME        Citrullinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Citrulline N5-carbamoyldihydrolase
REACTION    L-Citrulline + 2 H2O = L-Ornithine + CO2 + NH3
SUBSTRATE   L-Citrulline
            H2O
PRODUCT     L-Ornithine
            CO2
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.20
            ExPASy - ENZYME nomenclature database: 3.5.1.20
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.20
            BRENDA, the Enzyme Database: 3.5.1.20
///
ENTRY       EC 3.5.1.21
NAME        N-Acetyl-beta-alanine deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acetyl-beta-alanine amidohydrolase
REACTION    N-Acetyl-beta-alanine + H2O = Acetate + beta-Alanine
SUBSTRATE   N-Acetyl-beta-alanine
            H2O
PRODUCT     Acetate
            beta-Alanine
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.21
            ExPASy - ENZYME nomenclature database: 3.5.1.21
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.21
            BRENDA, the Enzyme Database: 3.5.1.21
///
ENTRY       EC 3.5.1.22
NAME        Pantothenase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Pantothenate amidohydrolase
REACTION    Pantothenate + H2O = Pantoate + beta-Alanine
SUBSTRATE   Pantothenate
            H2O
PRODUCT     Pantoate
            beta-Alanine
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.22
            ExPASy - ENZYME nomenclature database: 3.5.1.22
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.22
            BRENDA, the Enzyme Database: 3.5.1.22
///
ENTRY       EC 3.5.1.23
NAME        Ceramidase
            Acylsphingosine deacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acylsphingosine amidohydrolase
REACTION    N-Acylsphingosine + H2O = a Carboxylate + Sphingosine
SUBSTRATE   N-Acylsphingosine
            H2O
PRODUCT     Carboxylate
            Sphingosine
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
GENES       HSA: 427(ASAH)
DISEASE     MIM: 228000  N-acylsphingosine amidohydrolase (acid ceramidase)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.23
            ExPASy - ENZYME nomenclature database: 3.5.1.23
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.23
            BRENDA, the Enzyme Database: 3.5.1.23
///
ENTRY       EC 3.5.1.24
NAME        Choloylglycine hydrolase
            Glycocholase
            Bile salt hydrolase
            Choloyltaurine hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine
            $ amidohydrolase
REACTION    3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine +
            H2O = 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate + Glycine
SUBSTRATE   3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oylglycine
            H2O
            3alpha,12alpha-Dihydroxy-5beta-cholan-24-oylglycine
            Choloyl-taurine
PRODUCT     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate
            Glycine
            3alpha,12alpha-Dihydroxy-5beta-cholanate
COMMENT     Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on
            choloyl-taurine.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.24
            ExPASy - ENZYME nomenclature database: 3.5.1.24
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.24
            BRENDA, the Enzyme Database: 3.5.1.24
///
ENTRY       EC 3.5.1.25
NAME        N-Acetylglucosamine-6-phosphate deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acetyl-D-glucosamine-6-phosphate amidohydrolase
REACTION    N-Acetyl-D-glucosamine 6-phosphate + H2O =
            D-Glucosamine 6-phosphate + Acetate
SUBSTRATE   N-Acetyl-D-glucosamine 6-phosphate
            H2O
PRODUCT     D-Glucosamine 6-phosphate
            Acetate
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b0677(nagA)
            ECE: Z0824(nagA) Z4489
            ECS: ECs0707 ECs4015
            YPE: YPO2626(nagA)
            HIN: HI0140(nagA)
            PMU: PM0874(nagA)
            XFA: XF1465
            VCH: VC0994 VC1783
            PAE: PA3758
            MLO: mll4766
            SME: SMc02878(nagA)
            CCR: CC0443 CC0534
            BSU: BG12630(nagA)
            BHA: BH0421(nagA)
            SAU: SA0656(nagA)
            SAV: SAV0688(nagA)
            LLA: L173068(nagA)
            SPY: SPy1694(nagA)
            SPN: SP2056
            SPR: spr1867(nagA)
            CAC: CAC0188(nagA)
            MPU: MYPU_3690(nagA)
            MTU: Rv3332(nagA)
            MTC: MT3435
            BBU: BB0151(nagA)
            DRA: DRA0066
            TMA: TM0814
            SSO: SSO2673(nagA)
            CEL: F59B2.3
            DME: CG17065
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.25
            ExPASy - ENZYME nomenclature database: 3.5.1.25
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.25
            BRENDA, the Enzyme Database: 3.5.1.25
///
ENTRY       EC 3.5.1.26
NAME        N4-(beta-N-Acetylglucosaminyl)-L-asparaginase
            Aspartylglucosylamine deaspartylase
            Aspartylglucosylaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N4-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine amidohydrolase
REACTION    N4-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine + H2O =
            N-Acetyl-beta-D-glucosaminylamine + L-Aspartate
SUBSTRATE   N4-(beta-N-Acetyl-D-glucosaminyl)-L-asparagine
            H2O
PRODUCT     N-Acetyl-beta-D-glucosaminylamine
            L-Aspartate
COMMENT     Acts only on asparagine-oligosaccharides containing one amino
            acid, i.e. the asparagine has free alpha-amino and alpha-carboxyl
            groups. (cf. EC 3.5.1.52)
PATHWAY     PATH: MAP00511  Glycoprotein degradation
GENES       CEL: R04B3.2
            DME: CG10474 CG1827 CG4372
            HSA: 175(AGA)
DISEASE     MIM: 208400  Aspartylglucosaminidase
STRUCTURES  PDB: 1APY  9GAA  1APZ  1AYY  2GAC  9GAC  9GAF  2GAW  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.26
            ExPASy - ENZYME nomenclature database: 3.5.1.26
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.26
            BRENDA, the Enzyme Database: 3.5.1.26
            SCOP (Structural Classification of Proteins): 3.5.1.26
///
ENTRY       EC 3.5.1.27
NAME        N-Formylmethionylaminoacyl-tRNA deformylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Formyl-L-methionylaminoacyl-tRNA amidohydrolase
REACTION    N-Formyl-L-methionylaminoacyl-tRNA + H2O = Formate +
            L-Methionylaminoacyl-tRNA
SUBSTRATE   N-Formyl-L-methionylaminoacyl-tRNA
            H2O
PRODUCT     Formate
            L-Methionylaminoacyl-tRNA
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
STRUCTURES  PDB: 1BSJ  1BSK  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.27
            ExPASy - ENZYME nomenclature database: 3.5.1.27
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.27
            BRENDA, the Enzyme Database: 3.5.1.27
            SCOP (Structural Classification of Proteins): 3.5.1.27
///
ENTRY       EC 3.5.1.28
NAME        N-Acetylmuramoyl-L-alanine amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Mucopeptide amidohydrolase
REACTION    Hydrolyses the link between N-acetylmuramonyl residues and
            L-amino acid residues in certain cell-wall glycopeptides
SUBSTRATE   Glycopeptide
            H2O
PRODUCT     Glycoprotein
            N-Acetylmuramate
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b2435(amiA) b2817 b4169(amiB)
            ECE: Z3700(amiA) Z4134 Z5776(amiB)
            ECS: ECs3306 ECs3674 ECs5145
            YPE: YPO1023 YPO1715(ybjR)
            HIN: HI0066(amiB) HI1494
            PMU: PM0903
            XFA: XF0759
            VCH: VC0344
            PAE: PA4947(amiB) PA5538(amiA)
            BUC: BU576(amiB)
            NME: NMB0456 NMB0987 NMB1085
            NMA: NMA1188 NMA1303 NMA1864 NMA2028(amiC)
            HPY: HP0772(amiA)
            HPJ: jhp0709
            CJE: Cj1269c(amiA)
            MLO: mlr0213
            SME: SMc01335(amiC)
            CCR: CC1876
            BSU: BG10407(lytC) BG10505(cwlA) BG10825(cwlC) BG10962(xlyA)
                 BG11172(cwlJ) BG11439(sleB) BG11514(cwlD) BG11633(cwlH)
                 BG11717(yqiI) BG12699(xlyB) BG13322(ykvT) BG13590(blyA)
                 BG13806(yrvJ)
            BHA: BH0239(cwlD) BH0810 BH0966 BH1294(cwlC) BH1631(sleB) BH2879
                 BH3510 BH3665(lytC) BH3826(cwlJ)
            SAU: SA0905(atl) SA1458(lytH)
            SAV: SAV0900 SAV1039(atl) SAV1619(lytH)
            SPN: SP1937
            SPR: spr1754(lytA)
            CAC: CAC3092
            CTR: CT268
            CMU: TC0539
            CPN: CPn0417
            CPA: CP0337
            CPJ: amiA
            BBU: BB0625
            TPA: TP0247
            SYN: slr0891(amiA) slr1744(amiA) slr1910(amiA)
            DRA: DR1387 DR1632 DR2394 DR2567 DRC0013
            AAE: aq_1681(amiB)
STRUCTURES  PDB: 1ARO  1LBA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.28
            ExPASy - ENZYME nomenclature database: 3.5.1.28
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.28
            BRENDA, the Enzyme Database: 3.5.1.28
            SCOP (Structural Classification of Proteins): 3.5.1.28
///
ENTRY       EC 3.5.1.29
NAME        2-(Acetamidomethylene)succinate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     2-(Acetamidomethylene)succinate amidohydrolase (deaminating,
            $ decarboxylating)
REACTION    2-(Acetamidomethylene)succinate + 2 H2O = Acetate +
            Succinate semialdehyde + NH3 + CO2
SUBSTRATE   2-(Acetamidomethylene)succinate
            H2O
PRODUCT     Acetate
            Succinate semialdehyde
            NH3
            CO2
COMMENT     Involved in the degradation of pyridoxin in Pseudomonas.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.29
            ExPASy - ENZYME nomenclature database: 3.5.1.29
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.29
            BRENDA, the Enzyme Database: 3.5.1.29
///
ENTRY       EC 3.5.1.30
NAME        5-Aminopentanamidase
            5-Aminovaleramidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     5-Aminopentanamide amidohydrolase
REACTION    5-Aminopentanamide + H2O = 5-Aminopentanoate + NH3
SUBSTRATE   5-Aminopentanamide
            H2O
PRODUCT     5-Aminopentanoate
            NH3
COMMENT     The enzyme from Pseudomonas putida also acts on 4-aminobutanamide
            and, more slowly, on 6-aminohexanamide.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.30
            ExPASy - ENZYME nomenclature database: 3.5.1.30
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.30
            BRENDA, the Enzyme Database: 3.5.1.30
///
ENTRY       EC 3.5.1.31
NAME        Formylmethionine deformylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Formyl-L-methionine amidohydrolase
REACTION    N-Formyl-L-methionine + H2O = Formate + L-Methionine
SUBSTRATE   N-Formyl-L-methionine
            H2O
PRODUCT     Formate
            L-Methionine
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b3287(def)
            ECE: Z4657(def)
            ECS: ECs4152
            YPE: YPO0242(def)
            HIN: HI0622(def)
            PMU: PM1559(def)
            XFA: XF0926
            VCH: VC0046 VCA0150
            PAE: PA0019(def)
            BUC: BU496(def)
            NME: NMB0110
            NMA: NMA0164(def)
            HPY: HP0793(def)
            HPJ: jhp0729
            CJE: Cj0191c(def)
            RPR: RP208(def)
            RCO: RC0080(def3) RC0278(def1) RC0674(def2)
            MLO: mll4855
            SME: SMc01101(def1) SMc01262(def2)
            CCR: CC0272
            BSU: BG11815(ykrB) BG11933(def)
            BHA: BH2658
            SAU: SA0942(pdf1) SA1058
            SAV: SAV1075 SAV1202
            LLA: L154885(def)
            SPY: SPy1958(def)
            SPN: SP1456 SP1549
            SPR: spr1310(fms) spr1408(def)
            CAC: CAC1722(def) CAC2474(def)
            MGE: MG106(def)
            MPN: K04_orf216(def)
            MPU: MYPU_6890(def)
            UUR: UU465(def)
            MTU: Rv0429c(def)
            MTC: MT0444
            MLE: ML1929(def)
            CTR: CT353
            CMU: TC0632
            CPN: CPn1067
            CPA: CP0783
            CPJ: def
            BBU: BB0065(def)
            TPA: TP0757
            SYN: slr1549(def)
            DRA: DR2434
            AAE: aq_579(def)
            TMA: TM1661
STRUCTURES  PDB: 1BSZ  1BS7  1BS6  1DEF  1BS4  1DFF  1DTF  2DEF  2DTF  1BS8  
                 1BS5  1ICJ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.31
            ExPASy - ENZYME nomenclature database: 3.5.1.31
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.31
            BRENDA, the Enzyme Database: 3.5.1.31
            SCOP (Structural Classification of Proteins): 3.5.1.31
///
ENTRY       EC 3.5.1.32
NAME        Hippurate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Benzoylamino-aicd amidohydrolase
REACTION    Hippurate + H2O = Benzoate + Glycine
SUBSTRATE   Hippurate
            H2O
PRODUCT     Benzoate
            Glycine
COMMENT     Acts on various N-benzoylamino acids.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       CJE: Cj0985c(hipO)
            MLO: mlr3583
            SME: SMb21279 SMc00682(hipO1) SMc02256(hipO2)
            BSU: BG12596(hipO)
            SPR: spr1906(hipO)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.32
            ExPASy - ENZYME nomenclature database: 3.5.1.32
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.32
            BRENDA, the Enzyme Database: 3.5.1.32
///
ENTRY       EC 3.5.1.33
NAME        N-Acetylglucosamine deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acetyl-D-glucosamine amidohydrolase
REACTION    N-Acetyl-D-glucosamine + H2O = D-Glucosamine + Acetate
SUBSTRATE   N-Acetyl-D-glucosamine
            H2O
PRODUCT     D-Glucosamine
            Acetate
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.33
            ExPASy - ENZYME nomenclature database: 3.5.1.33
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.33
            BRENDA, the Enzyme Database: 3.5.1.33
///
ENTRY       EC 3.5.1.34
NAME        Deleted entry
            Acetylhistidine deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
COMMENT     Deleted entry. Identical with EC 3.4.13.5.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.34
            ExPASy - ENZYME nomenclature database: 3.5.1.34
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.34
///
ENTRY       EC 3.5.1.35
NAME        D-Glutaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     D-Glutamine amidohydrolase
REACTION    D-Glutamine + H2O = D-Glutamate + NH3
SUBSTRATE   D-Glutamine
            H2O
PRODUCT     D-Glutamate
            NH3
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.35
            ExPASy - ENZYME nomenclature database: 3.5.1.35
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.35
            BRENDA, the Enzyme Database: 3.5.1.35
///
ENTRY       EC 3.5.1.36
NAME        N-Methyl-2-oxoglutaramate hydrolase
            5-Hydroxy-N-methylpyroglutamate synthase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Methyl-2-oxoglutaramate methylamidohydrolase
REACTION    N-Methyl-2-oxoglutaramate + H2O = 2-Oxoglutarate + Methylamine
SUBSTRATE   N-Methyl-2-oxoglutaramate
            H2O
PRODUCT     2-Oxoglutarate
            Methylamine
COMMENT     In the reverse reaction, the product cyclizes non-enzymically to
            2-hydroxy-N-methyl-5-oxoproline.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.36
            ExPASy - ENZYME nomenclature database: 3.5.1.36
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.36
            BRENDA, the Enzyme Database: 3.5.1.36
///
ENTRY       EC 3.5.1.37
NAME        Deleted entry
            4-L-Aspartylglycosylamine amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
COMMENT     Deleted entry. Identical with EC 3.5.1.26.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.37
            ExPASy - ENZYME nomenclature database: 3.5.1.37
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.37
///
ENTRY       EC 3.5.1.38
NAME        Glutamin-(asparagin-)ase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Glutamate(L-asparagine) amidohydrolase
REACTION    L-Glutamine + H2O = L-Glutamate + NH3
SUBSTRATE   L-Glutamine
            L-Asparagine
            H2O
PRODUCT     L-Glutamate
            L-Aspartate
            NH3
COMMENT     A-Asparagine is hydrolysed at 0.8 of the rate of L-glutamine; the
            the D-isomers are also hydrolysed, more slowly.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00144  [LIVM]-x(2)-T-G-G-T-[IV]-[AGS]
            PS: PS00917  G-x-[LIVM]-x(2)-H-G-T-D-T-[LIVM]
STRUCTURES  PDB: 1DJO  1DJP  4PGA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.38
            ExPASy - ENZYME nomenclature database: 3.5.1.38
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.38
            BRENDA, the Enzyme Database: 3.5.1.38
            SCOP (Structural Classification of Proteins): 3.5.1.38
///
ENTRY       EC 3.5.1.39
NAME        Alkylamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Methylhexanamide amidohydrolase
REACTION    N-Methylhexanamide + H2O = Hexanoate + Methylamine
SUBSTRATE   N-Methylhexanamide
            H2O
PRODUCT     Hexanoate
            Methylamine
COMMENT     The enzyme hydrolyses N-monosubstituted and N,N-disubstituted
            amides, and there is some activity towards primary amides. It has
            little or no activity towards short-chain substrates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.39
            ExPASy - ENZYME nomenclature database: 3.5.1.39
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.39
            BRENDA, the Enzyme Database: 3.5.1.39
///
ENTRY       EC 3.5.1.40
NAME        Acylagmatine amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Benzoylagmatine amidohydrolase
REACTION    Benzoylagmatine + H2O = Benzoate + Agmatine
SUBSTRATE   Benzoylagmatine
            H2O
            Acetylagmatine
            Propanoylagmatine
            Bleomycin B2
PRODUCT     Benzoate
            Agmatine
            Acetate
            Propanoate
COMMENT     Also acts on acetylagmatine, propanoylagmatine and bleomycin B2.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.40
            ExPASy - ENZYME nomenclature database: 3.5.1.40
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.40
            BRENDA, the Enzyme Database: 3.5.1.40
///
ENTRY       EC 3.5.1.41
NAME        Chitin deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Chitin amidohydrolase
REACTION    Chitin + H2O = Chitosan + Acetate
SUBSTRATE   Chitin
            H2O
PRODUCT     Chitosan
            Acetate
COMMENT     Hydrolyses the N-acetamido groups of N-acetyl-D-glucosamine
            residues in chitin.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       SCE: YLR307W(CDA1) YLR308W(CDA2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.41
            ExPASy - ENZYME nomenclature database: 3.5.1.41
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.41
            BRENDA, the Enzyme Database: 3.5.1.41
///
ENTRY       EC 3.5.1.42
NAME        Nicotinamide-nucleotide amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Nicotinamide-D-ribonucleotide amidohydrolase
REACTION    Nicotinamide D-ribonucleotide + H2O =
            Nicotinate D-ribonucleotide + NH3
SUBSTRATE   Nicotinamide D-ribonucleotide
            H2O
PRODUCT     Nicotinate D-ribonucleotide
            NH3
COMMENT     Also acts more slowly on beta-nicotinamide D-ribonucleoside.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.42
            ExPASy - ENZYME nomenclature database: 3.5.1.42
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.42
            BRENDA, the Enzyme Database: 3.5.1.42
///
ENTRY       EC 3.5.1.43
NAME        Peptidyl-glutaminase
            Peptidoglutaminase I
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Peptidyl-L-glutamine amidohydrolase
REACTION    alpha-N-Peptidyl-L-glutamine + H2O = alpha-N-Peptidyl-L-glutamate
            + NH3
SUBSTRATE   alpha-N-Peptidyl-L-glutamine
            H2O
PRODUCT     alpha-N-Peptidyl-L-glutamate
            NH3
COMMENT     Specific for the hydrolysis of the gamma-amide of glutamine
            substituted at the alpha-amino group, e.g. glycyl-L-glutamine,
            N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.43
            ExPASy - ENZYME nomenclature database: 3.5.1.43
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.43
            BRENDA, the Enzyme Database: 3.5.1.43
///
ENTRY       EC 3.5.1.44
NAME        Protein-glutamine glutaminase
            Peptidoglutaminase II
            Glutaminylpeptide glutaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Protein-L-glutamine amidohydrolase
REACTION    Protein glutamine + H2O = Protein glutamate + NH3
SUBSTRATE   Protein glutamine
            H2O
PRODUCT     Protein glutamate
            NH3
COMMENT     Specific for the hydrolysis of the gamma-amide of glutamine
            substituted at the carboxyl position or both the alpha-amino and
            carboxyl positions, e.g. L-glutaminylglycine and L-phenylalanyl-
            L-glutaminylglycine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.44
            ExPASy - ENZYME nomenclature database: 3.5.1.44
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.44
            BRENDA, the Enzyme Database: 3.5.1.44
///
ENTRY       EC 3.5.1.45
NAME        Deleted entry
            Urease (ATP-hydrolysing)
            Urea carboxylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
COMMENT     Deleted entry. Now listed only as EC 6.3.4.6 - Urea carboxylase.
STRUCTURES  PDB: 1QAZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.45
            ExPASy - ENZYME nomenclature database: 3.5.1.45
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.45
            BRENDA, the Enzyme Database: 3.5.1.45
            SCOP (Structural Classification of Proteins): 3.5.1.45
///
ENTRY       EC 3.5.1.46
NAME        6-Aminohexanoate-dimer hydrolase
            6-Aminohexanoic acid oligomer hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-(6-Aminohexanoyl)-6-amino-hexanoate amidohydrolase
REACTION    N-(6-Aminohexanoyl)-6-aminohexanoate + H2O = 2 6-Aminohexanoate
SUBSTRATE   N-(6-Aminohexanoyl)-6-aminohexanoate
            H2O
PRODUCT     6-Aminohexanoate
COMMENT     Also hydrolyses, more slowly, oligomers of 6-aminohexanoate
            containing up to six residues; the residues are removed
            sequenctially from the N-terminus.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.46
            ExPASy - ENZYME nomenclature database: 3.5.1.46
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.46
            BRENDA, the Enzyme Database: 3.5.1.46
///
ENTRY       EC 3.5.1.47
NAME        N-Acetyldiaminopimelate deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N6-Acetyl-LL-2,6-diaminoheptanedioate amidohydrolase
REACTION    N6-Acetyl-LL-2,6-diaminoheptanedioate + H2O = Acetate +
            LL-2,6-Diaminoheptanedioate
SUBSTRATE   N6-Acetyl-LL-2,6-diaminoheptanedioate
            H2O
PRODUCT     Acetate
            LL-2,6-Diaminoheptanedioate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.47
            ExPASy - ENZYME nomenclature database: 3.5.1.47
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.47
            BRENDA, the Enzyme Database: 3.5.1.47
///
ENTRY       EC 3.5.1.48
NAME        Acetylspermidine deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N1-Acetylspermidine amidohydrolase
REACTION    N1-Acetylspermidine + H2O = Acetate + Spermidine
SUBSTRATE   N1-Acetylspermidine
            H2O
            N8-Acetylspermidine
            N1-Acetylspermidine
PRODUCT     Acetate
            Spermidine
COMMENT     Also hydrolyses N8-acetylspermidine and N1-acetylspermidine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.48
            ExPASy - ENZYME nomenclature database: 3.5.1.48
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.48
            BRENDA, the Enzyme Database: 3.5.1.48
///
ENTRY       EC 3.5.1.49
NAME        Formamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Formamide amidohydrolase
REACTION    Formamide + H2O = Formate + NH3
SUBSTRATE   Formamide
            H2O
PRODUCT     Formate
            NH3
COMMENT     Also acts, more slowly, on acetamide, propanamide and butanamide.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.49
            ExPASy - ENZYME nomenclature database: 3.5.1.49
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.49
            BRENDA, the Enzyme Database: 3.5.1.49
///
ENTRY       EC 3.5.1.50
NAME        Pentanamidase
            Valeramidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Pentanamide amidohydrolase
REACTION    Pentanamide + H2O = Pentanoate + NH3
SUBSTRATE   Pentanamide
            H2O
PRODUCT     Pentanoate
            NH3
COMMENT     Also acts, more slowly, on other short-chain aliphatic amides.
            Different from EC 3.5.1.49.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.50
            ExPASy - ENZYME nomenclature database: 3.5.1.50
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.50
            BRENDA, the Enzyme Database: 3.5.1.50
///
ENTRY       EC 3.5.1.51
NAME        4-Acetamidobutyryl-CoA deacetylase
            Aminobutyryl-CoA thiolesterase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     4-Acetamidobutyryl-CoA amidohydrolase
REACTION    4-Acetamidobutanoyl-CoA + H2O = Acetate + 4-Aminobutanoyl-CoA
SUBSTRATE   4-Acetamidobutanoyl-CoA
            H2O
PRODUCT     Acetate
            4-Aminobutanoyl-CoA
COMMENT     The enzyme also hydrolyses 4-aminobutanoyl-CoA to aminobutanoate
            and coenzyme A.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.51
            ExPASy - ENZYME nomenclature database: 3.5.1.51
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.51
            BRENDA, the Enzyme Database: 3.5.1.51
///
ENTRY       EC 3.5.1.52
NAME        Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
            Glycopeptide N-glycosidase
            Glycopeptidase
            N-Oligosaccharide glycopeptidase
            N-Glycanase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-linked-glycopeptide-N4-(N-acetyl-beta-D-glucosaminyl)-
            -L-asparagine amidohydrolase
REACTION    Hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue
            in which the glucosamine residue may be further glucosylated, to
            yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a
            peptide containing an aspartic residue
SUBSTRATE   N4-(Acetyl-beta-D-glucosaminyl)asparagine
            H2O
PRODUCT     N-Acetyl-beta-D-glucosaminylamine
            Peptide
COMMENT     Does not  act on (GlcNAc)Asn, because it requires the presence of
            more than two amino-acid residues in the substrate
            (cf. EC 3.5.1.26). The plant enzyme was previously erroneously
            listed as EC 3.2.2.18.
STRUCTURES  PDB: 1PNF  1PGS  1PNG  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.52
            ExPASy - ENZYME nomenclature database: 3.5.1.52
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.52
            BRENDA, the Enzyme Database: 3.5.1.52
            SCOP (Structural Classification of Proteins): 3.5.1.52
///
ENTRY       EC 3.5.1.53
NAME        N-Carbamoylputrescine amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Carbamoylputrescine amidohydrolase
REACTION    N-Carbamoylputrescine + H2O = Putrescine + CO2 + NH3
SUBSTRATE   N-Carbamoylputrescine
            H2O
PRODUCT     Putrescine
            CO2
            NH3
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.53
            ExPASy - ENZYME nomenclature database: 3.5.1.53
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.53
            BRENDA, the Enzyme Database: 3.5.1.53
///
ENTRY       EC 3.5.1.54
NAME        Allophanate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Urea-1-carboxylate amidohydrolase
REACTION    Urea-1-carboxylate + H2O = 2 CO2 + 2 NH3
SUBSTRATE   Urea-1-carboxylate
            H2O
PRODUCT     CO2
            NH3
COMMENT     The yeast enzyme (but not that from green algae) also catalyses
            the reaction of EC 6.3.4.6, thus bringing about the hydrolysis of
            urea to CO2 and NH3 in the presence of ATP and bicarbonate.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       SCE: YBR208C(DUR1)
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.54
            ExPASy - ENZYME nomenclature database: 3.5.1.54
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.54
            BRENDA, the Enzyme Database: 3.5.1.54
///
ENTRY       EC 3.5.1.55
NAME        Long-chain-fatty-acyl-glutamate deacylase
            Long-chain aminoacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Long-chain-fatty-acyl-L-glutamate amidohydrolase
REACTION    N-Long-chain-fatty-acyl-L-glutamate + H2O =
            a Long-chain carboxylate + L-Glutamate
SUBSTRATE   N-Long-chain-fatty-acyl-L-glutamate
            H2O
PRODUCT     Long-chain carboxylate
            L-Glutamate
COMMENT     Does not act on acyl derivatives of other amino acids.  Optimum
            chain length of acyl residue is 12 to 16.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.55
            ExPASy - ENZYME nomenclature database: 3.5.1.55
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.55
            BRENDA, the Enzyme Database: 3.5.1.55
///
ENTRY       EC 3.5.1.56
NAME        N,N-dimethylformamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N,N-Dimethylformamide amidohydrolase
REACTION    N,N-Dimethylformamide + H2O = Dimethylamine + Formate
SUBSTRATE   N,N-Dimethylformamide
            H2O
PRODUCT     Dimethylamine
            Formate
COFACTOR    Iron
COMMENT     An iron protein. Also acts on N-ethylformamide and
            N-methylformamide and, more slowly, on N,N-diethylformamide,
            N,N-dimethylacetamide and unsubstituted acyl amides.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.56
            ExPASy - ENZYME nomenclature database: 3.5.1.56
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.56
            BRENDA, the Enzyme Database: 3.5.1.56
///
ENTRY       EC 3.5.1.57
NAME        Tryptophanamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Tryptophanamide amidohydrolase
REACTION    L-Tryptophanamide + H2O = L-Tryptophan + NH3
SUBSTRATE   L-Tryptophanamide
            H2O
PRODUCT     L-Tryptophan
            NH3
COFACTOR    Manganese
COMMENT     Requires Mn2+. Also acts on N-ethylformamide and L-tyrosinamide,
            and on some tryptophan dipeptides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.57
            ExPASy - ENZYME nomenclature database: 3.5.1.57
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.57
            BRENDA, the Enzyme Database: 3.5.1.57
///
ENTRY       EC 3.5.1.58
NAME        N-Benzyloxycarbonylglycine hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Benzyloxycarbonylglycine urethanehydrolase
REACTION    N-Benzyloxycarbonylglycine + H2O = Benzyl alcohol + CO2 + Glycine
SUBSTRATE   N-Benzyloxycarbonylglycine
            H2O
PRODUCT     Benzyl alcohol
            CO2
            Glycine
COFACTOR    Cobalt
            Zinc
COMMENT     Also acts, more slowly, on N-benzyloxycarbonylalanine, but not on
            the corresponding derivatives of other amino acids or on
            N-bezyloxycarbonylpeptides.  Requires Co2+ or Zn2+.
            cf. EC 3.5.1.64.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.58
            ExPASy - ENZYME nomenclature database: 3.5.1.58
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.58
            BRENDA, the Enzyme Database: 3.5.1.58
///
ENTRY       EC 3.5.1.59
NAME        N-Carbamoylsarcosine amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Carbamoylsarcosine amidohydrolase
REACTION    N-Carbamoylsarcosine + H2O = Sarcosine + CO2 + NH3
SUBSTRATE   N-Carbamoylsarcosine
            H2O
PRODUCT     Sarcosine
            CO2
            NH3
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
STRUCTURES  PDB: 1NBA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.59
            ExPASy - ENZYME nomenclature database: 3.5.1.59
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.59
            BRENDA, the Enzyme Database: 3.5.1.59
            SCOP (Structural Classification of Proteins): 3.5.1.59
///
ENTRY       EC 3.5.1.60
NAME        N-(Long-chain-acyl)ethanolamine deacylase
            N-Acylethanolamine amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-(Long-chain-acyl)ethanolamine amidohydrolase
REACTION    N-(Long-chain-acyl)ethanolamine + H2O = a Long-chain carboxylate +
            Ethanolamine
SUBSTRATE   N-(Long-chain-acyl)ethanolamine
            H2O
PRODUCT     Long-chain carboxylate
            Ethanolamine
COMMENT     Does not act on N-acylsphingosine or N,O-diacylethanolamine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.60
            ExPASy - ENZYME nomenclature database: 3.5.1.60
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.60
            BRENDA, the Enzyme Database: 3.5.1.60
///
ENTRY       EC 3.5.1.61
NAME        Mimosinase
            Mimosine amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Mimosine amidohydrolase
REACTION    (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O =
            3-Hydoxy-4-oxo-4H-pyrid-4-one + L-Serine
SUBSTRATE   (S)-2-Amino-3-(3-hydoxy-4-oxo-4H-pyridin-1-yl)propanoate
            H2O
PRODUCT     3-Hydoxy-4-oxo-4H-pyrid-4-one
            L-Serine
COMMENT     An enzyme from Leucena leucocophala leaf, which also contains the
            toxic amino acid, mimosine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.61
            ExPASy - ENZYME nomenclature database: 3.5.1.61
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.61
            BRENDA, the Enzyme Database: 3.5.1.61
///
ENTRY       EC 3.5.1.62
NAME        Acetylputrescine deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Acetylputrescine acetylhydrolase
REACTION    N-Acetylputrescine + H2O = Acetate + Putrescine
SUBSTRATE   N-Acetylputrescine
            H2O
PRODUCT     Acetate
            Putrescine
COMMENT     The enzyme from Micrococcus luteus also acts on N6-acetyl-
            spermidine adn acetylcadaverine, more slowly.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.62
            ExPASy - ENZYME nomenclature database: 3.5.1.62
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.62
            BRENDA, the Enzyme Database: 3.5.1.62
///
ENTRY       EC 3.5.1.63
NAME        4-Acetamidobutyrate deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     4-Acetamidobutanoate amidohydrolase
REACTION    4-Acetamidobutanoate + H2O = Acetate + 4-Aminobutanoate
SUBSTRATE   4-Acetamidobutanoate
            H2O
            N-Acetyl-beta-alanine
            5-Acetamidopentanoate
PRODUCT     Acetate
            4-Aminobutanoate
            5-Aminopentanoate
COMMENT     Also acts on N-acetyl-beta-alanine and 5-acetamidopentanoate.
PATHWAY     PATH: MAP00310  Lysine degradation
            PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.63
            ExPASy - ENZYME nomenclature database: 3.5.1.63
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.63
            BRENDA, the Enzyme Database: 3.5.1.63
///
ENTRY       EC 3.5.1.64
NAME        N(alpha)-benzyloxycarbonyl-leucine hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N(alpha)-Benzyloxycarbonyl-L-leucine urethanehydrolase
REACTION    N(alpha)-Benzyloxycarbonyl-L-leucine + H2O = Benzyl alcohol +
            CO2 + L-Leucine
SUBSTRATE   N(alpha)-Benzyloxycarbonyl-L-leucine
            H2O
            N(alpha)-t-Butoxycarbonyl-L-leucine
PRODUCT     Benzyl alcohol
            CO2
            L-Leucine
COMMENT     Also acts on N(alpha)-t-butoxycarbonyl-L-leucine, and, more
            slowly, on the corresponding derivatives of L-aspartate,
            L-methionine, L-glutamate and L-alanine. cf. EC 3.5.1.58.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.64
            ExPASy - ENZYME nomenclature database: 3.5.1.64
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.64
            BRENDA, the Enzyme Database: 3.5.1.64
///
ENTRY       EC 3.5.1.65
NAME        Theanine hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Theanine amidohydrolase
REACTION    N5-Ethyl-L-glutamine + H2O = L-Glutamate + Ethylamine
SUBSTRATE   N5-Ethyl-L-glutamine
            H2O
PRODUCT     L-Glutamate
            Ethylamine
COMMENT     Also acts on other N-alkyl-L-glutamines
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.65
            ExPASy - ENZYME nomenclature database: 3.5.1.65
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.65
            BRENDA, the Enzyme Database: 3.5.1.65
///
ENTRY       EC 3.5.1.66
NAME        2-(Hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     2-(Hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase
REACTION    2-(Hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O =
            Acetate + 2-(Hydroxymethyl)-4-oxobutanoate + NH3 + CO2
SUBSTRATE   2-(Hydroxymethyl)-3-(acetamidomethylene)succinate
            H2O
PRODUCT     Acetate
            2-(Hydroxymethyl)-4-oxobutanoate
            NH3
            CO2
COMMENT     Involved in the degradation of pyridoxin by Pseudomonas and
            Arthrobacter.
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.66
            ExPASy - ENZYME nomenclature database: 3.5.1.66
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.66
            BRENDA, the Enzyme Database: 3.5.1.66
///
ENTRY       EC 3.5.1.67
NAME        4-Methyleneglutaminase
            4-Methyleneglutamine deamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     4-Methylene-L-glutamine amidohydrolase
REACTION    4-Methylene-L-glutamine + H2O = 4-Methylene-L-glutamate + NH3
SUBSTRATE   4-Methylene-L-glutamine
            H2O
PRODUCT     4-Methylene-L-glutamate
            NH3
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.67
            ExPASy - ENZYME nomenclature database: 3.5.1.67
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.67
            BRENDA, the Enzyme Database: 3.5.1.67
///
ENTRY       EC 3.5.1.68
NAME        N-Formylglutamate deformylase
            beta-Citryl-L-glutamate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Formyl-L-glutamate amidohydrolase
REACTION    N-Formyl-L-glutamate + H2O = Formate + L-Glutamate
SUBSTRATE   N-Formyl-L-glutamate
            H2O
PRODUCT     Formate
            L-Glutamate
COMMENT     The animal enzyme also acts on beta-citryl-L-glutamate and
            beta-citryl-L-glutamine.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.68
            ExPASy - ENZYME nomenclature database: 3.5.1.68
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.68
            BRENDA, the Enzyme Database: 3.5.1.68
///
ENTRY       EC 3.5.1.69
NAME        Glycosphingolipid deacylase
            Glycosphingolipid ceramide deacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Glycosphingolipid amidohydrolase
REACTION    Hydrolysis of gangliosides and neutral glycosphingolipids,
            releasing fatty acids to form the lyso-derivatives
SUBSTRATE   Ganglioside
            Neutral glycosphingolipid
            H2O
PRODUCT     Fatty acid
COMMENT     Does not act on sphingolipids such as ceramide. Not identical with
            EC 3.5.1.23.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.69
            ExPASy - ENZYME nomenclature database: 3.5.1.69
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.69
            BRENDA, the Enzyme Database: 3.5.1.69
///
ENTRY       EC 3.5.1.70
NAME        Aculeacin-A deacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Aculeacin-A amidohydrolase
REACTION    Hydrolysis of the amide bond in aculeacin A and related neutral
            lipopeptide antibiotics, releasing the long-chain fatty acid
            side-chain.
SUBSTRATE   Aculeacin A
            H2O
PRODUCT     Fatty acid
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.70
            ExPASy - ENZYME nomenclature database: 3.5.1.70
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.70
            BRENDA, the Enzyme Database: 3.5.1.70
///
ENTRY       EC 3.5.1.71
NAME        N-Feruloylglycine deacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Feruloylglycine amidohydrolase
REACTION    N-Feruloylglycine + H2O = Ferulate + Glycine
SUBSTRATE   N-Feruloylglycine
            H2O
PRODUCT     Ferulate
            Glycine
COMMENT     Hydrolyses cinnamoyl series. Not identical with EC 3.5.1.14.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.71
            ExPASy - ENZYME nomenclature database: 3.5.1.71
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.71
            BRENDA, the Enzyme Database: 3.5.1.71
///
ENTRY       EC 3.5.1.72
NAME        D-Benzoylarginine-4-nitroanilide amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     N-Benzoyl-D-arginine-4-nitroanilide amidohydrolase
REACTION    N-Benzoyl-D-arginine-4-nitroanilide + H2O = N-Benzoyl-D-arginine
            + 4-Nitroanilide
SUBSTRATE   N-Benzoyl-D-arginine-4-nitroanilide
            H2O
PRODUCT     N-Benzoyl-D-arginine
            4-Nitroanilide
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.72
            ExPASy - ENZYME nomenclature database: 3.5.1.72
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.72
            BRENDA, the Enzyme Database: 3.5.1.72
///
ENTRY       EC 3.5.1.73
NAME        Carnitinamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     L-Carnitinamide amidohydrolase
REACTION    L-Carnitinamide + H2O = L-Carnitine + NH3
SUBSTRATE   L-Carnitinamide
            H2O
PRODUCT     L-Carnitine
            NH3
COMMENT     Does not act on D-carnitinamide.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.73
            ExPASy - ENZYME nomenclature database: 3.5.1.73
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.73
            BRENDA, the Enzyme Database: 3.5.1.73
///
ENTRY       EC 3.5.1.74
NAME        Chenodeoxycholoyltaurine hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Chenodeoxycholoyltaurine amidohydrolase
REACTION    Chenodeoxycholoyltaurine + H2O = Chenodeoxycholate + Taurine
SUBSTRATE   Chenodeoxycholoyltaurine
            H2O
PRODUCT     Chenodeoxycholate
            Taurine
COMMENT     Some other taurine conjugates are hysrolysed, but not glycine
            conjugates of bile acids.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.74
            ExPASy - ENZYME nomenclature database: 3.5.1.74
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.74
            BRENDA, the Enzyme Database: 3.5.1.74
///
ENTRY       EC 3.5.1.75
NAME        Urethanase
            Urethane hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Urethane amidohydrolase (decarboxylating)
REACTION    Urethane + H2O = Ethanol + CO2 + NH3
SUBSTRATE   Urethane
            H2O
PRODUCT     Ethanol
            CO2
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.75
            ExPASy - ENZYME nomenclature database: 3.5.1.75
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.75
            BRENDA, the Enzyme Database: 3.5.1.75
///
ENTRY       EC 3.5.1.76
NAME        Arylalkyl acylamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Acetylarylalkylamine + H2O = Arylalkylamine + Acetate
SUBSTRATE   N-Acetylarylalkylamine
            H2O
PRODUCT     Arylalkylamine
            Acetate
COMMENT     Strict specificity for N-Acetyl arylalkylamines, including
            N-Acetyl-2-phenylethylamide, N-Acetyl-3-phenylpropylamine,
            N-Acetyldopamine, N-Acetylserotonin and Melatonin. It also
            accepts Arylalkyl acetates but not Acetanilide derivatives,
            which are common substrates of Aryl acylamidase
            (EC 3.5.1.13).
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.76
            ExPASy - ENZYME nomenclature database: 3.5.1.76
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.76
///
ENTRY       EC 3.5.1.77
NAME        N-Carbamoyl-D-amino acid hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Carbamoyl-D-amino acid + H2O = D-Amino acid + NH3 + CO2
SUBSTRATE   N-Carbamoyl-D-amino acid
            H2O
PRODUCT     D-Amino acid
            NH3
            CO2
COMMENT     A strict stereospecificity for N-Carbamoyl D-amino acid and
            does not act upon the corresponding L-Amino acids or
            N-Formyl amino acids, N-Carbamoyl-sarcosine, -Citrulline,
            -Allantoin and Ureidopropionate which are substrates for
            other aminohydrolases.
GENES       MTH: MTH1811
STRUCTURES  PDB: 1ERZ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.77
            ExPASy - ENZYME nomenclature database: 3.5.1.77
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.77
///
ENTRY       EC 3.5.1.78
NAME        Glutathionylspermidine amidase
            GSP amidase
            Glutathionylspermidine amidohydrolase (spermidine-forming)
            Gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine + H2O =
            gamma-L-Glutamyl-L-cysteinyl-glycine + Spermidine
SUBSTRATE   N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine
            H2O
PRODUCT     gamma-L-Glutamyl-L-cysteinyl-glycine
            Spermidine
COMMENT     Transforms glutathionylspermidine into glutathione and spermidine.
            The enzyme from E.coli is bifunctional and also catalyses the
            glutathionylspermidine synthase (EC 6.3.1.8) reaction, resulting in
            a net hydrolysis of ATP.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.78
            ExPASy - ENZYME nomenclature database: 3.5.1.78
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.78
///
ENTRY       EC 3.5.1.79
NAME        Phthalyl amidase
            O-Phthalyl amidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    Phthalylamide + H2O = Phthalic acid + a Substituted amine
SUBSTRATE   Phthalylamide
            H2O
PRODUCT     Phthalic acid
            Substituted amine
COMMENT     Phthalyl is used to mean 2-carboxybenzoyl.
            The enzyme from Xanthobacter agilis hydrolyses phthalylated amino
            acids, peptides, beta-lactams, aromatic and aliphatic amines.
            The substituent on nitrogen may be an alkyl group, but may also be
            complex, giving an amino acid or peptide derivative.
            Substitutions on the phthalyl ring include 6-F, 6-NH2, 3-OH, and a
            nitrogen in the aromatic ring ortho to the carboxyl group attached
            to the amine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.79
            ExPASy - ENZYME nomenclature database: 3.5.1.79
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.79
///
ENTRY       EC 3.5.1.80
NAME        N-Acetylgalactosamine-6-phosphate deacetylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Acetyl-D-galactosamine 6-phosphate + H2O =
            D-Galactosamine 6-phosphate + Acetate
SUBSTRATE   N-Acetyl-D-galactosamine 6-phosphate
            H2O
PRODUCT     D-Galactosamine 6-phosphate
            Acetate
GENES       ECO: b3135(agaA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.80
            ExPASy - ENZYME nomenclature database: 3.5.1.80
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.80
///
ENTRY       EC 3.5.1.81
NAME        N-Acyl-D-amino-acid deacylase
            D-Aminoacylase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Acyl-D-amino acid + H2O = an Acid + D-Amino acid
SUBSTRATE   N-Acyl-D-amino acid
            H2O
PRODUCT     Acid
            D-Amino acid
COFACTOR    Zinc
COMMENT     Has a wide specificity; hydrolyses N-acyl derivative of neutral
            D-amino acids.
            Used in separating D- and L-amino acids.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.81
            ExPASy - ENZYME nomenclature database: 3.5.1.81
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.81
///
ENTRY       EC 3.5.1.82
NAME        N-Acyl-D-glutamate deacylase
            N-Acyl-D-glutamate amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Acyl-D-glutamate + H2O = Carboxylate + D-Glutamate
SUBSTRATE   N-Acyl-D-glutamate
            H2O
PRODUCT     Carboxylate
            D-Glutamate
COFACTOR    Zinc
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.82
            ExPASy - ENZYME nomenclature database: 3.5.1.82
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.82
///
ENTRY       EC 3.5.1.83
NAME        N-Acyl-D-aspartate deacylase
            N-Acyl-D-aspartate amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
REACTION    N-Acyl-D-aspartate + H2O = Carboxylate + D-Aspartate
SUBSTRATE   N-Acyl-D-aspartate
            H2O
PRODUCT     Carboxylate
            D-Aspartate
COFACTOR    Zinc
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.83
            ExPASy - ENZYME nomenclature database: 3.5.1.83
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.83
///
ENTRY       EC 3.5.1.84
NAME        Biuret amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     Biuret amidohydrolase
REACTION    Biuret + H2O = Urea + CO2 + NH3
SUBSTRATE   Biuret
            H2O
PRODUCT     Urea
            CO2
            NH3
COMMENT     Involved in a pathway by which the herbicide atrazine, 2-chloro-4-
            (ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.84
            ExPASy - ENZYME nomenclature database: 3.5.1.84
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.84
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.84
///
ENTRY       EC 3.5.1.85
NAME        (S)-N-Acetyl-1-phenylethylamine hydrolase
            (S)-N-Acetyl-1-phenylethylamine amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amides
SYSNAME     (S)-N-Acetylphenylethylamine:H2O hydrolase
REACTION    N-Acetylphenylethylamine = Phenylethylamine + Acetate
SUBSTRATE   N-Acetylphenylethylamine
PRODUCT     Phenylethylamine
            Acetate
INHIBITOR   Phenylmethanesulfonyl fluoride
COMMENT     Inhibited by phenylmethanesulfonyl fluoride. Some related
            acetylated compounds are hydrolysed with variable enantiomeric
            selectivities.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.1.85
            ExPASy - ENZYME nomenclature database: 3.5.1.85
            WIT (What Is There) Metabolic Reconstruction: 3.5.1.85
///
ENTRY       EC 3.5.2.1
NAME        Barbiturase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     Barbiturate amidohydrolase
REACTION    Barbiturate + H2O = Malonate + Urea
SUBSTRATE   Barbiturate
            H2O
PRODUCT     Malonate
            Urea
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.1
            ExPASy - ENZYME nomenclature database: 3.5.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.1
            BRENDA, the Enzyme Database: 3.5.2.1
///
ENTRY       EC 3.5.2.2
NAME        Dihydropyrimidinase
            Hydantoinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     5,6-Dihydropyrimidine amidohydrolase
REACTION    5,6-Dihydrouracil + H2O = 3-Ureidopropanoate
SUBSTRATE   5,6-Dihydrouracil
            Dihydrothymine
            Hydantoin
            H2O
PRODUCT     3-Ureidopropanoate
            3-Ureidoisobutyrate
COMMENT     Also acts on dihydrothymine and hydantoin.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       PAE: PA0441
            MLO: mll1629
            SME: SMc01821(dht)
            ATH: At5g12200(MXC9.16)
            CEL: C47E12.8
            HSA: 1807(DPYS)
DISEASE     MIM: 222748  Dihydropyrimidinase
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.2
            ExPASy - ENZYME nomenclature database: 3.5.2.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.2
            BRENDA, the Enzyme Database: 3.5.2.2
///
ENTRY       EC 3.5.2.3
NAME        Dihydroorotase
            Carbamoylaspartic dehydrase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     (S)-Dihydroorotate amidohydrolase
REACTION    (S)-Dihydroorotate + H2O = N-Carbamoyl-L-aspartate
SUBSTRATE   (S)-Dihydroorotate
            H2O
PRODUCT     N-Carbamoyl-L-aspartate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b1062(pyrC)
            ECE: Z1699(pyrC)
            ECS: ECs1440
            YPE: YPO1587(pyrC)
            XFA: XF0988
            VCH: VCA0925
            PAE: PA0401 PA3527(pyrC) PA5541
            BUC: BU334(pyrC)
            NME: NMB0682
            NMA: NMA0884(pyrC)
            HPY: HP0266(pyrC) HP0581(pyrC)
            HPJ: jhp0251 jhp0528
            CJE: Cj0259(pyrC) Cj1195c(pyrC2)
            MLO: mlr0687 mlr7790
            SME: SMc02166(pyrC)
            ATU: AGR_C_703
            CCR: CC0388 CC2444
            BSU: BG10714(pyrC)
            BHA: BH2538(pyrC)
            SAU: SA1044(pyrC)
            SAV: SAV1188(pyrC)
            LLA: L81189(pyrC)
            SPY: SPy0907(pyrC)
            SPN: SP1167
            SPR: spr1053(pyrC)
            CAC: CAC0519(pyrC)
            MTU: Rv1381(pyrC)
            MTC: MT1425
            MLE: ML0533(pyrC)
            SYN: sll1018(pyrC) slr0406(pyrC)
            DRA: DR1106
            AAE: aq_806(pyrC)
            TMA: TM0335
            MJA: MJ1490(pyrC)
            MTH: MTH1127
            AFU: AF2250(pyrC)
            HAL: VNG2533G(pyrC)
            TAC: Ta1319
            TVO: TVG0282239
            PHO: PH1963
            PAB: PAB1149(pyrC)
            APE: APE0261
            SSO: SSO0611(pyrC)
            STO: ST1478
            SCE: YJL130C(URA2) YLR420W(URA4)
            SPO: SPAC16.03C(spac16.03c) URA1(ura1)
            ATH: At4g22930(F7H19.110)
            CEL: D2085.1
            HSA: 790(CAD)
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
            PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00482  D-[LIVMFYWSAP]-H-[LIVA]-H-[LIVF]-[RN]-x-[PGANF]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
STRUCTURES  PDB: 1J79  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.3
            ExPASy - ENZYME nomenclature database: 3.5.2.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.3
            BRENDA, the Enzyme Database: 3.5.2.3
///
ENTRY       EC 3.5.2.4
NAME        Carboxymethylhydantoinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     L-5-Carboxymethylhydantoin amidohydrolase
REACTION    L-5-Carboxymethylhydantoin + H2O = N-Carbamoyl-L-aspartate
SUBSTRATE   L-5-Carboxymethylhydantoin
            H2O
PRODUCT     N-Carbamoyl-L-aspartate
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.4
            ExPASy - ENZYME nomenclature database: 3.5.2.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.4
            BRENDA, the Enzyme Database: 3.5.2.4
///
ENTRY       EC 3.5.2.5
NAME        Allantoinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     Allantoin amidohydrolase
REACTION    Allantoin + H2O = Allantoate
SUBSTRATE   Allantoin
            H2O
PRODUCT     Allantoate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0512(ybbX)
            ECE: Z0666 Z0667
            ECS: ECs0573 ECs0574
            BSU: BG13982(pucH)
            BHA: BH2309
            DRA: DR1153
            SCE: YIR027C(DAL1)
MOTIF       PS: PS00482  D-[LIVMFYWSAP]-H-[LIVA]-H-[LIVF]-[RN]-x-[PGANF]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.5
            ExPASy - ENZYME nomenclature database: 3.5.2.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.5
            BRENDA, the Enzyme Database: 3.5.2.5
///
ENTRY       EC 3.5.2.6
NAME        beta-Lactamase
            Penicillinase
            Cephalosporinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     beta-Lactamhydrolase
REACTION    a beta-Lactam + H2O = a Substituted beta-amino acid
SUBSTRATE   beta-Lactam
            Penicillin
            Cephalosporin
            H2O
PRODUCT     Substituted beta-amino acid
INHIBITOR   m-Carboxyphenyl phenylacetamidomethylphosphonate
COMMENT     A group of enzymes of varing specificity hydrolysing  beta-
            lactams; some act more rapidly on penicillins, some more rapidly
            on cephalosporins. The latter were formerly listed as
            EC 3.5.2.8.
GENES       ECO: b4150(ampC)
            ECE: Z5757(ampC)
            ECS: ECs5131
            PAE: PA4110(ampC) PA5514
            CJE: Cj0299
            SME: SMb21600(ampC) SMc00047(bla) SMc02026
            BSU: BG11016(penP) BG11507(ybxI)
            SAU: SAP010(blaZ)
            MTU: Rv2068c(blaC)
            MTC: MT2128
            SYN: slr0121 slr0319(blaOXA-3)
            DRA: DR0433
            PAB: PAB0087(pbp)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00146  [FY]-x-[LIVMFY]-x-S-[TV]-x-K-x(4)-[AGLM]-x(2)-[LC]
            PS: PS00336  F-E-[LIVM]-G-S-[LIVMG]-[SA]-K
            PS: PS00337  [PA]-x-S-[ST]-F-K-[LIV]-[PAL]-x-[STA]-[LI]
            PS: PS00743  [LI]-x-[STN]-[HN]-x-H-[GSTA]-D-x(2)-G-[GP]-x(7,8)-[GS]
            PS: PS00744  P-x(3)-[LIVM](2)-x-G-x-C-[LIVMF](2)-K
STRUCTURES  PDB: 1GCE  1A7T  1A8T  1ALQ  1AXB  1BC2  1BLC  1BLH  1BLP  1BLS  
                 1BMC  1BSG  1BT5  1BTL  1BUE  1BUL  1BVT  1BZA  1C3B  1CK3  
                 1DD6  1DDK  1DJA  1DJB  1DJC  1DXK  1DY6  1E25  1E3U  1E4D  
                 1ERM  1ERO  1ERQ  1ESU  1EWZ  1FCM  1FCN  1FCO  1FOF  1FQG  
                 1FR1  1FR6  1FSW  1FSY  1G56  1G68  1G6A  1GA0  1GA9  1GHP  
                 1GHI  1GHM  2BLS  1H8Y  1H8Z  1HTZ  1I5Q  1IEL  1IEM  1JJE  
                 1JJT  1JTD  1KGE  1KGF  1KGG  1MBL  1MFO  1OME  1PIO  1SHV  
                 1SML  1TEM  1XPB  1ZNB  2BC2  2BLM  2BMI  2BLT  4ZNB  2ZNB  
                 3BC2  3BLM  3BLS  3ZNB  4BLM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.6
            ExPASy - ENZYME nomenclature database: 3.5.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.6
            BRENDA, the Enzyme Database: 3.5.2.6
            SCOP (Structural Classification of Proteins): 3.5.2.6
///
ENTRY       EC 3.5.2.7
NAME        Imidazolonepropionase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     4-Imidazolone-5-propanoate amidohydrolase
REACTION    4-Imidazolone-5-propanoate + H2O = N-Formimino-L-glutamate
SUBSTRATE   4-Imidazolone-5-propanoate
            H2O
PRODUCT     N-Formimino-L-glutamate
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       YPE: YPO1972(hutI)
            VCH: VC1205
            PAE: PA5092(hutI)
            MLO: mlr8319 mlr9376
            SME: SMb21166(hutI)
            CCR: CC0960
            BSU: BG11100(hutI)
            BHA: BH1984(hutI)
            SAU: SA2121(hutI)
            SAV: SAV2315(hutI)
            SPY: SPy2081(hutI)
            DRA: DRA0148
            HAL: VNG1211G(hutI)
            TAC: Ta0238
            TVO: TVG1430123
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.7
            ExPASy - ENZYME nomenclature database: 3.5.2.7
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.7
            BRENDA, the Enzyme Database: 3.5.2.7
///
ENTRY       EC 3.5.2.8
NAME        Deleted entry
            Cephalosporinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
COMMENT     Deleted entry. Now included with EC 3.5.2.6 - beta-Lactamase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.8
            ExPASy - ENZYME nomenclature database: 3.5.2.8
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.8
///
ENTRY       EC 3.5.2.9
NAME        5-Oxoprolinase (ATP-hydrolysing)
            Pyroglutamase (ATP-hydrolysing)
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     5-Oxo-L-proline amidohydrolase (ATP-hydrolysing)
REACTION    ATP + 5-Oxo-L-proline + 2 H2O = ADP + Orthophosphate +
            L-Glutamate
SUBSTRATE   ATP
            5-Oxo-L-proline
            H2O
PRODUCT     ADP
            Orthophosphate
            L-Glutamate
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.9
            ExPASy - ENZYME nomenclature database: 3.5.2.9
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.9
            BRENDA, the Enzyme Database: 3.5.2.9
///
ENTRY       EC 3.5.2.10
NAME        Creatininase
            Creatinine amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     Creatinine amidohydrolase
REACTION    Creatinine + H2O = Creatine
SUBSTRATE   Creatinine
            H2O
PRODUCT     Creatine
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       BHA: BH0226
            SYN: slr0596
            TMA: TM0413
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.10
            ExPASy - ENZYME nomenclature database: 3.5.2.10
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.10
            BRENDA, the Enzyme Database: 3.5.2.10
///
ENTRY       EC 3.5.2.11
NAME        L-Lysine-lactamase
            L-alpha-Aminocaprolactam hydrolase
            L-Lysinamidase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     L-Lysine-1,6-lactam lactamhydrolase
REACTION    L-Lysine 1,6-lactam + H2O = L-Lysine
SUBSTRATE   L-Lysine 1,6-lactam
            H2O
            L-Lysinamide
PRODUCT     L-Lysine
COMMENT     Also hydrolyses L-lysinamide.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.11
            ExPASy - ENZYME nomenclature database: 3.5.2.11
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.11
            BRENDA, the Enzyme Database: 3.5.2.11
///
ENTRY       EC 3.5.2.12
NAME        6-Aminohexanoate-cyclic-dimer hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     1,8-Diazacyclotetradecane-2,9-dione lactamhydrolase
REACTION    1,8-Diazacyclotetradecane-2,9-dione + H2O =
            N-(6-Aminohexanoyl)-6-aminohexanoate
SUBSTRATE   1,8-Diazacyclotetradecane-2,9-dione
            H2O
PRODUCT     N-(6-Aminohexanoyl)-6-aminohexanoate
COMMENT     The cyclic dimer of 6-aminohexanoate is converted to the linear
            dimer.
GENES       MLO: mlr4825
            CCR: CC1323
            DRA: DR0235
MOTIF       PS: PS00571  G-[GA]-S-[GS]-[GS]-G-x-[GSA]-[GSAVY]-x-[LIVM]-[GSA]-
                         x(6)-[GSAT]-x-[GA]-x-[DE]-x-[GA]-x-S-[LIVM]-R-x-P-
                         [GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.12
            ExPASy - ENZYME nomenclature database: 3.5.2.12
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.12
            BRENDA, the Enzyme Database: 3.5.2.12
///
ENTRY       EC 3.5.2.13
NAME        2,5-Dioxopiperazine hydrolase
            Cyclo(Gly-Gly) hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     2,5-Dioxopiperazine amidohydrolase
REACTION    2,5-Dioxopiperazine + H2O = Glycylglycine
SUBSTRATE   2,5-Dioxopiperazine
            H2O
PRODUCT     Glycylglycine
COMMENT     Highly specific; does not hydrolyse other dioxopiperazines,
            glycylglycine, proteins or barbiturates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.13
            ExPASy - ENZYME nomenclature database: 3.5.2.13
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.13
            BRENDA, the Enzyme Database: 3.5.2.13
///
ENTRY       EC 3.5.2.14
NAME        N-Methylhydantoinase (ATP-hydrolysing)
            N-Methylhydantoin amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     N-Methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)
REACTION    ATP + N-Methylimidazolidine-2,4-dione + 2 H2O = ADP +
            Orthophosphate + N-Carbamoylsarcosine
SUBSTRATE   ATP
            N-Methylimidazolidine-2,4-dione
            H2O
PRODUCT     ADP
            Orthophosphate
            N-Carbamoylsarcosine
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
GENES       MLO: mlr4786 mlr4788 mlr9030 mlr9031
            AAE: aq_1925(hyuB) aq_708(hyuA)
            MJA: MJ0963(hyuB) MJ0964(hyuA)
            TVO: TVG0834091 TVG0835694
            APE: APE1328 APE1331 APE2528 APE2530
            SSO: SSO1662(huyB-1) SSO1663(huyA-1) SSO2008(huyA-2)
                 SSO2010(hyuB-2) SSO2934(hyuB-3) SSO2936(hyuA-3)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.14
            ExPASy - ENZYME nomenclature database: 3.5.2.14
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.14
            BRENDA, the Enzyme Database: 3.5.2.14
///
ENTRY       EC 3.5.2.15
NAME        Cyanuric acid amidohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amides
SYSNAME     Cyanuric acid amidohydrolase
REACTION    Cyanuric acid +  H2O = Biuret + CO2
SUBSTRATE   Cyanuric acid
            H2O
PRODUCT     Biuret
            CO2
COMMENT     Involved in a pathway by which the herbicide atrazine, 2-chloro-4-
            (ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.2.15
            ExPASy - ENZYME nomenclature database: 3.5.2.15
            WIT (What Is There) Metabolic Reconstruction: 3.5.2.15
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.2.15
///
ENTRY       EC 3.5.3.1
NAME        Arginase
            Arginine amidinase
            Canavanase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     L-Arginine amidinohydrolase
REACTION    L-Arginine + H2O = L-Ornithine + Urea
SUBSTRATE   L-Arginine
            alpha-N-Substituted L-arginine
            Canavanine
            H2O
PRODUCT     L-Ornithine
            Urea
COMMENT     Also hydrolyses alpha-N-substituted L-arginines and canavanine.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
GENES       HPY: HP1399(rocF)
            HPJ: jhp1427
            MLO: mll6778 mlr5015
            SME: SMa1711(argI2) SMc03091(argI1)
            ATU: AGR_pTi_56
            BSU: BG10932(rocF)
            BHA: BH2984(rocF) BH3948
            SAU: SA1968(arg)
            SAV: SAV2151(arg)
            CAC: CAC1054
            SYN: sll0228(speB1)
            DRA: DR0651
            SCE: YPL111W(CAR1)
            SPO: ARU1(aru1) CAR1_1(car1)
            ATH: At4g08900(T3H13.7)
            DME: CG18104
            HSA: 383(ARG1) 384(ARG2)
DISEASE     MIM: 207800  Arginase, liver
MOTIF       PS: PS00147  [LIVMF]-G-G-x-H-x-[LIVMT]-[STAV]-x-[PAG]-x(3)-[GSTA]
            PS: PS00148  [LIVM](2)-x-[LIVMFY]-D-[AS]-H-x-D
            PS: PS01053  [ST]-[LIVMFY]-D-[LIVM]-D-x(3)-[PAQ]-x(3)-P-[GSA]-x(7)-G
STRUCTURES  PDB: 1HQG  1CEV  1D3V  1HQ5  1HQF  2CEV  1HQH  1HQX  1RLA  2RLA  
                 3CEV  3RLA  4CEV  4RLA  5CEV  5RLA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.1
            ExPASy - ENZYME nomenclature database: 3.5.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.1
            BRENDA, the Enzyme Database: 3.5.3.1
            SCOP (Structural Classification of Proteins): 3.5.3.1
///
ENTRY       EC 3.5.3.2
NAME        Guanidinoacetase
            Glycocyaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Guanidinoacetate amidohydrolase
REACTION    Guanidinoacetate  + H2O = Glycine + Urea
SUBSTRATE   Guanidinoacetate
            H2O
PRODUCT     Glycine
            Urea
COFACTOR    Manganese
COMMENT     Requires Mn2+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.2
            ExPASy - ENZYME nomenclature database: 3.5.3.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.2
            BRENDA, the Enzyme Database: 3.5.3.2
///
ENTRY       EC 3.5.3.3
NAME        Creatinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Creatine amidinohydrolase
REACTION    Creatine + H2O = Sarcosine + Urea
SUBSTRATE   Creatine
            H2O
PRODUCT     Sarcosine
            Urea
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
STRUCTURES  PDB: 1CHM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.3
            ExPASy - ENZYME nomenclature database: 3.5.3.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.3
            BRENDA, the Enzyme Database: 3.5.3.3
            SCOP (Structural Classification of Proteins): 3.5.3.3
///
ENTRY       EC 3.5.3.4
NAME        Allantoicase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Allantoate amidinohydrolase
REACTION    Allantoate + H2O = (-)-Ureidoglycolate + Urea
SUBSTRATE   Allantoate
            H2O
            (+)-Ureidoglycolate
PRODUCT     (-)-Ureidoglycolate
            Urea
            Glyoxylate
COMMENT     Also hydrolyses (+)-ureidogylcolate to glyoxylate and urea.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       PAE: PA1515(alc)
            SME: SMb21283
            SCE: YIR029W(DAL2)
            SPO: SPAC1F7.09C(spac1f7.09c)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.4
            ExPASy - ENZYME nomenclature database: 3.5.3.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.4
            BRENDA, the Enzyme Database: 3.5.3.4
///
ENTRY       EC 3.5.3.5
NAME        Formiminoaspartate deiminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     N-Formimino-L-aspartate iminohydrolase
REACTION    N-Formimino-L-aspartate + H2O = N-Formyl-L-aspartate + NH3
SUBSTRATE   N-Formimino-L-aspartate
            H2O
PRODUCT     N-Formyl-L-aspartate
            NH3
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.5
            ExPASy - ENZYME nomenclature database: 3.5.3.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.5
            BRENDA, the Enzyme Database: 3.5.3.5
///
ENTRY       EC 3.5.3.6
NAME        Arginine deiminase
            Arginine dihydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     L-Arginine iminohydrolase
REACTION    L-Arginine + H2O = L-Citrulline + NH3
SUBSTRATE   L-Arginine
            H2O
            Canavanine
PRODUCT     L-Citrulline
            NH3
COMMENT     Also acts on canavanine.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       VCH: VC0423
            PAE: PA5171(arcA)
            MLO: mll6733
            SME: SMa0693(arcA1) SMa0695(arcB) SMa1670(arcA2)
            SAU: SA2428(arcA)
            SAV: SAV2619(arcA)
            LLA: L0329(arcA)
            SPY: SPy1547(sagP)
            SPN: SP2148
            SPR: spr1955(arcA-truncation) spr1956(arcA-truncation)
            MPN: H03_orf438(arcA) H10_orf198(arcA) H10_orf238(arcA)
            MTU: Rv1001(arcA)
            MTC: MT1030
            BBU: BB0841(arcA)
            STO: ST1031
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.6
            ExPASy - ENZYME nomenclature database: 3.5.3.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.6
            BRENDA, the Enzyme Database: 3.5.3.6
///
ENTRY       EC 3.5.3.7
NAME        Guanidinobutyrase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     4-Guanidinobutanoate amidinohydrolase
REACTION    4-Guanidinobutanoate + H2O = 4-Aminobutanoate + Urea
SUBSTRATE   4-Guanidinobutanoate
            H2O
PRODUCT     4-Aminobutanoate
            Urea
COFACTOR    Manganese
COMMENT     Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate
            and 6-guanidinohexanoate.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.7
            ExPASy - ENZYME nomenclature database: 3.5.3.7
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.7
            BRENDA, the Enzyme Database: 3.5.3.7
///
ENTRY       EC 3.5.3.8
NAME        Formiminoglutamase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     N-Formimino-L-glutamate formiminohydrolase
REACTION    N-Formimino-L-glutamate + H2O = L-Glutamate + Formamide
SUBSTRATE   N-Formimino-L-glutamate
            H2O
PRODUCT     L-Glutamate
            Formamide
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       VCH: VC1204
            PAE: PA5091(hutG)
            MLO: mlr8322
            SME: SMb21164(hutG)
            CCR: CC0958
            BSU: BG11099(hutG)
            BHA: BH1985(hutG)
            SAU: SA2125
            SAV: SAV2319(hutG)
            HAL: VNG1209G(hutG)
MOTIF       PS: PS00147  [LIVMF]-G-G-x-H-x-[LIVMT]-[STAV]-x-[PAG]-x(3)-[GSTA]
            PS: PS00148  [LIVM](2)-x-[LIVMFY]-D-[AS]-H-x-D
            PS: PS01053  [ST]-[LIVMFY]-D-[LIVM]-D-x(3)-[PAQ]-x(3)-P-[GSA]-x(7)-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.8
            ExPASy - ENZYME nomenclature database: 3.5.3.8
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.8
            BRENDA, the Enzyme Database: 3.5.3.8
///
ENTRY       EC 3.5.3.9
NAME        Allantoate deiminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Allantoate amidinohydrolase (decarboxylating)
REACTION    Allantoate + H2O = Ureidoglycine + NH3 + CO2
SUBSTRATE   Allantoate
            H2O
PRODUCT     Ureidoglycine
            NH3
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.9
            ExPASy - ENZYME nomenclature database: 3.5.3.9
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.9
            BRENDA, the Enzyme Database: 3.5.3.9
///
ENTRY       EC 3.5.3.10
NAME        D-Arginase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     D-Arginine amidinohydrolase
REACTION    D-Arginine + H2O = D-Ornithine + Urea
SUBSTRATE   D-Arginine
            H2O
PRODUCT     D-Ornithine
            Urea
PATHWAY     PATH: MAP00472  D-Arginine and D-ornithine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.10
            ExPASy - ENZYME nomenclature database: 3.5.3.10
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.10
            BRENDA, the Enzyme Database: 3.5.3.10
///
ENTRY       EC 3.5.3.11
NAME        Agmatinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Agmatine amidinohydrolase
REACTION    Agmatine + H2O = Putrescine + Urea
SUBSTRATE   Agmatine
            H2O
PRODUCT     Putrescine
            Urea
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b2937(speB)
            ECE: Z4281(speB)
            ECS: ECs3812
            PMU: PM1381(speE)
            VCH: VCA0814
            PAE: PA0288(speB1) PA1421(speB2)
            NME: NMB0469
            NMA: NMA2016(speB)
            MLO: mll0412 mll8453 mlr4895
            SME: SMc01802(speB) SMc01967(speB2)
            BSU: BG12461(speB)
            BHA: BH3810
            SYN: sll1077(speB2)
            DRA: DRA0149
            MJA: MJ0309
            MTH: MTH868
            AFU: AF0646(speB)
            HAL: VNG1767G(speB)
            TAC: Ta1058
            TVO: TVG0528110
            PHO: PH0083
            PAB: PAB0050(speB)
            APE: APE0316 APE1637
            SSO: SSO0445(speB-1) SSO2732(speB-2)
            STO: ST0352
            SPO: SPAC11D3.09(spac11d3.09)
MOTIF       PS: PS00147  [LIVMF]-G-G-x-H-x-[LIVMT]-[STAV]-x-[PAG]-x(3)-[GSTA]
            PS: PS00148  [LIVM](2)-x-[LIVMFY]-D-[AS]-H-x-D
            PS: PS01053  [ST]-[LIVMFY]-D-[LIVM]-D-x(3)-[PAQ]-x(3)-P-[GSA]-x(7)-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.11
            ExPASy - ENZYME nomenclature database: 3.5.3.11
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.11
            BRENDA, the Enzyme Database: 3.5.3.11
///
ENTRY       EC 3.5.3.12
NAME        Agmatine deiminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Agmatine iminohydrolase
REACTION    Agmatine + H2O = N-Carbamoylputrescine + NH3
SUBSTRATE   Agmatine
            H2O
PRODUCT     N-Carbamoylputrescine
            NH3
COMMENT     The plant enzyme also catalyses the reaction of EC 2.1.3.3,
            2.1.3.6 and 2.7.2.2, thus functioning as aputrescine synthase,
            converting agmatine and ornithine into putrescine and citrulline
            respectively.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.12
            ExPASy - ENZYME nomenclature database: 3.5.3.12
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.12
            BRENDA, the Enzyme Database: 3.5.3.12
///
ENTRY       EC 3.5.3.13
NAME        Formiminoglutamate deiminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     N-Formimino-L-glutamate iminohydrolase
REACTION    N-Formimino-L-glutamate + H2O = N-Formyl-L-glutamate + NH3
SUBSTRATE   N-Formimino-L-glutamate
            H2O
PRODUCT     N-Formyl-L-glutamate
            NH3
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.13
            ExPASy - ENZYME nomenclature database: 3.5.3.13
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.13
            BRENDA, the Enzyme Database: 3.5.3.13
///
ENTRY       EC 3.5.3.14
NAME        Amidinoaspartase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     N-Amidino-L-aspartate amidinohydrolase
REACTION    N-Amidino-L-aspartate + H2O = L-Aspartate + Urea
SUBSTRATE   N-Amidino-L-aspartate
            H2O
            N-Amidino-L-glutamate
PRODUCT     L-Aspartate
            Urea
            L-Glutamate
COMMENT     Also acts slowly on N-amidino-L-glutamate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.14
            ExPASy - ENZYME nomenclature database: 3.5.3.14
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.14
            BRENDA, the Enzyme Database: 3.5.3.14
///
ENTRY       EC 3.5.3.15
NAME        Protein-arginine deiminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Protein-L-arginine iminohydrolase
REACTION    Protein arginine + H2O = Protein L-citrulline + NH3
SUBSTRATE   Protein arginine
            H2O
            N-Acyl-L-arginine
            L-Arginine ester
PRODUCT     Protein L-citrulline
            NH3
            N-Acyl-L-citrulline
            L-Citrulline ester
COMMENT     Also acts on N-acyl-L-arginine and, more slowly, on L-arginine
            esters.
GENES       MMU: 97534(Pdi)
            HSA: 11240(PDI2) 23569(PAD) 29943 51702(LOC51702)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.15
            ExPASy - ENZYME nomenclature database: 3.5.3.15
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.15
            BRENDA, the Enzyme Database: 3.5.3.15
///
ENTRY       EC 3.5.3.16
NAME        Methylguanidinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Methylguanidine amidinohydrolase
REACTION    Methylguanidine + H2O = Methylamine + Urea
SUBSTRATE   Methylguanidine
            H2O
PRODUCT     Methylamine
            Urea
COMMENT     Acts on some other alkylguanidines, very slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.16
            ExPASy - ENZYME nomenclature database: 3.5.3.16
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.16
            BRENDA, the Enzyme Database: 3.5.3.16
///
ENTRY       EC 3.5.3.17
NAME        Guanidinopropionase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     3-Guanidinopropanoate amidinopropionase
REACTION    3-Guanidinopropanoate + H2O = beta-Alanine + Urea
SUBSTRATE   3-Guanidinopropanoate
            H2O
PRODUCT     beta-Alanine
            Urea
COFACTOR    Manganese
COMMENT     Requires Mn2+. Also acts, more slowly, on taurocyamine and
            4-guanidinobutanoate.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.17
            ExPASy - ENZYME nomenclature database: 3.5.3.17
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.17
            BRENDA, the Enzyme Database: 3.5.3.17
///
ENTRY       EC 3.5.3.18
NAME        Dimethylargininase
            Dimethylarginine dimethylaminohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     NG,NG-Dimethyl-L-arginine dimethylamidohydrolase
REACTION    NG,NG-Dimethyl-L-arginine + H2O = Dimethylamine + L-Citrulline
SUBSTRATE   NG,NG-Dimethyl-L-arginine
            H2O
PRODUCT     Dimethylamine
            L-Citrulline
COMMENT     Also acts on NG-monomethyl-L-arginine
GENES       SME: SMb21304
            DME: CG1764
            HSA: 23564(DDAH2) 23576(DDAH1)
STRUCTURES  PDB: 1H70  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.18
            ExPASy - ENZYME nomenclature database: 3.5.3.18
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.18
            BRENDA, the Enzyme Database: 3.5.3.18
///
ENTRY       EC 3.5.3.19
NAME        Ureidoglycolate hydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     Ureidoglycolate amidohydrolase (decarboxylating)
REACTION    (-)-Ureidoglycolate + H2O = Glyoxylate + 2 NH3 + CO2
SUBSTRATE   (-)-Ureidoglycolate
            H2O
PRODUCT     Glyoxylate
            NH3
            CO2
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0505(ybbT)
            SME: SMb20873(allA)
            SCE: YIR032C(DAL3)
            SPO: SPAC19G12.04(spac19g12.04)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.19
            ExPASy - ENZYME nomenclature database: 3.5.3.19
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.19
            BRENDA, the Enzyme Database: 3.5.3.19
///
ENTRY       EC 3.5.3.20
NAME        Diguanidinobutanase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
SYSNAME     1,4-Diguanidinobutane amidinohydrolase
REACTION    1,4-Diguanidinobutane + H2O = Agmatine + Urea
SUBSTRATE   1,4-Diguanidinobutane
            H2O
PRODUCT     Agmatine
            Urea
COMMENT     Other diguanidinoalkanes with 3 to 10 methylene groups can act,
            more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.20
            ExPASy - ENZYME nomenclature database: 3.5.3.20
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.20
            BRENDA, the Enzyme Database: 3.5.3.20
///
ENTRY       EC 3.5.3.21
NAME        Methylenediurea deiminase
            Methylenediurease
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In linear amidines
REACTION    Methylenediurea + 2 H2O = N-(Hydroxymethyl)urea + 2 NH3 + CO2;
            Methylenediurea + H2O = N-(Carboxyaminomethyl)urea + NH3;
            N-(Carboxyaminomethyl)urea = N-(Aminomethyl)urea + CO2;
            N-(Aminomethyl)urea + H2O = N-(Hydroxymethyl)urea + NH3
SUBSTRATE   Methylenediurea
            H2O
            N-(Carboxyaminomethyl)urea
            N-(Aminomethyl)urea
            Dimethylenetriurea
            Trimethylenetetraurea
PRODUCT     N-(Hydroxymethyl)urea
            NH3
            CO2
            N-(Carboxyaminomethyl)urea
            N-(Aminomethyl)urea
COMMENT     The methylenediurea is hydrolysed and decarboxylated to give an
            aminated methylurea, which then spontaneously hydrolyses to
            hydroxymethylurea:
            (1) NH2-CO-NH-CH2-NH-CO-NH2 + H2O = N-(carboxyaminomethyl)urea +
                NH3
            (2) N-(carboxyaminomethyl)urea = N-(aminomethyl)urea + CO2
            (spontaneous).
            (3) N-(aminomethyl)urea + H2O = N-(hydroxymethyl)urea + NH3
            (spontaneous).
            The enzyme from Ochrobactrum anthropi also hydrolyses
            dimethylenetriurea and trimethylenetetraurea as well as
            ureidoglycolate, which is hydrolysed to urea and glyoxylate, and
            allantoate, which is hydrolysed to ureidoglycolate, ammonia and
            carbon dioxide.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.3.21
            ExPASy - ENZYME nomenclature database: 3.5.3.21
            WIT (What Is There) Metabolic Reconstruction: 3.5.3.21
///
ENTRY       EC 3.5.4.1
NAME        Cytosine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Cytosine aminohydrolase
REACTION    Cytosine + H2O = Uracil + NH3
SUBSTRATE   Cytosine
            H2O
            5-Methylcytosine
PRODUCT     Uracil
            NH3
COMMENT     Also acts on 5-methylcytosine
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b0337(codA)
            ECE: Z0433(codA)
            ECS: ECs0390
            YPE: YPO0162(codA)
            PMU: PM0565
            PAE: PA0437(codA)
            NMA: NMA1129
            RCO: RC1285
            MLO: mll1290 mlr5363
            SME: SMa2371(codA1)
            SYN: slr1237(codA)
            SSO: SSO2770(codA)
            SCE: YPR062W(FCY1)
MOTIF       PS: PS00903  [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-
                         x(2,8)-C-x(3)-[LIVM]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.1
            ExPASy - ENZYME nomenclature database: 3.5.4.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.1
            BRENDA, the Enzyme Database: 3.5.4.1
///
ENTRY       EC 3.5.4.2
NAME        Adenine deaminase
            Adenase
            Adenine aminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Adenine aminohydrolase
REACTION    Adenine + H2O = Hypoxanthine + NH3
SUBSTRATE   Adenine
            H2O
PRODUCT     Hypoxanthine
            NH3
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3665(yicP)
            ECE: Z5155(yicP)
            ECS: ECs4602
            MLO: mlr0157
            SME: SMa1715(adeC3) SMa1718(adeC4) SMb21278(adeC2) SMc01533(adeC1)
            BSU: BG11044(adeC) BG12829(yerA)
            BHA: BH0637 BH0640(adeC)
            CAC: CAC0887(adeC)
            BBU: BBK17(adeC)
            DRA: DRA0270
            MJA: MJ1459(adeC)
            MTH: MTH866
            AFU: AF0240(adeC)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.2
            ExPASy - ENZYME nomenclature database: 3.5.4.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.2
            BRENDA, the Enzyme Database: 3.5.4.2
///
ENTRY       EC 3.5.4.3
NAME        Guanine deaminase
            Guanase
            Guanine aminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Guanine aminohydrolase
REACTION    Guanine + H2O = Xanthine + NH3
SUBSTRATE   Guanine
            H2O
PRODUCT     Xanthine
            NH3
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2883(ygfP)
            ECE: Z4222(ygfP)
            ECS: ECs3756
            PAE: PA1521
            MLO: mlr5142
            SME: SMb20849(guaD2) SMb21293(guaD1)
            CCR: CC2616
            BSU: BG13240(gde)
            CAC: CAC0282
            DRA: DRA0180
            SCE: YDL238C
            SPO: SPCC1672.03C(spcc1672.03c)
            DME: CG18143
            HSA: 9615(GDA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.3
            ExPASy - ENZYME nomenclature database: 3.5.4.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.3
            BRENDA, the Enzyme Database: 3.5.4.3
///
ENTRY       EC 3.5.4.4
NAME        Adenosine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Adenosine aminohydrolase
REACTION    Adenosine + H2O = Inosine + NH3
SUBSTRATE   Adenosine
            H2O
PRODUCT     Inosine
            NH3
INHIBITOR   Nebularine
            6-Hydroxyl-1,6-dihydropurine ribonucleoside
COMMENT     Inhibited by Nebularine and 6-hydroxyl-1,6-dihydropurine
            ribonucleoside (Science (1989) 243, 1591-1593).
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b1623(add)
            ECE: Z2628(add)
            ECS: ECs2331
            VCH: VC2751
            PAE: PA0148
            MLO: mll3163
            SME: SMc04120(add)
            ATU: AGR_C_218
            CCR: CC3180
            LLA: L87453(add)
            CAC: CAC3005(add)
            MTU: Rv3313c(add)
            MLE: ML0700(add)
            TPA: TP0045
            SCE: YNL141W(AAH1)
            SPO: SPBC1198.02(spbc1198.02) SPBC1683.02(spbc1683.02)
            CEL: C06G3.5
            MMU: 87916(Ada)
            HSA: 100(ADA)
DISEASE     MIM: 102700  Adenosine deaminase
MOTIF       PS: PS00485  [SA]-[LIVM]-[NGS]-[STA]-D-D-P
STRUCTURES  PDB: 1UIO  1FKX  2ADA  1A4L  1A4M  1ADD  1FKW  1UIP  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.4
            ExPASy - ENZYME nomenclature database: 3.5.4.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.4
            BRENDA, the Enzyme Database: 3.5.4.4
            SCOP (Structural Classification of Proteins): 3.5.4.4
///
ENTRY       EC 3.5.4.5
NAME        Cytidine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Cytidine aminohydrolase
REACTION    Cytidine + H2O = Uridine + NH3
SUBSTRATE   Cytidine
            H2O
PRODUCT     Uridine
            NH3
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2143(cdd)
            ECE: Z3398(cdd)
            ECS: ECs3035
            YPE: YPO1512(cdd)
            HIN: HI1350(cdd)
            PMU: PM0259(cdd)
            VCH: VC1231
            MLO: mlr3158
            SME: SMc04124(cdd)
            ATU: AGR_C_209
            CCR: CC3012
            BSU: BG10477(cdd)
            BHA: BH1366(cdd)
            SAU: SA1397(cdd)
            SAV: SAV1557(cdd)
            LLA: L62931(cdd)
            SPY: SPy1230(cdd)
            SPN: SP0844
            SPR: spr0746(cdd) spr1188(cdd)
            CAC: CAC1544 CAC2609
            MGE: MG052(cdd)
            MPN: D09_orf133(cdd)
            MPU: MYPU_3790(cdd)
            UUR: UU531(cdd)
            MTU: Rv3315c(cdd)
            MTC: MT3416
            MLE: ML2174(cdd)
            BBU: BB0618(cdd)
            DRA: DR2177
            TMA: TM0846
            HAL: VNG0896G(cda)
            APE: APE1038
            SCE: YLR245C(CDD1)
            SPO: PCD1(pcd1)
            ATH: At2g19570(F3P11.17) At4g29570(T16L4.80) At4g29580(T16L4.90)
                 At4g29600(T16L4.110) At4g29610(T16L4.120) At4g29620(T16L4.130)
                 At4g29630(T16L4.140) At4g29640(T16L4.150) At4g29650(T16L4.160)
            CEL: C47D2.2 F49E8.4
            DME: CG8349 CG8360
            HSA: 978(CDA)
DISEASE     MIM: 123920  Cytidine deaminase
MOTIF       PS: PS00903  [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-
                         x(2,8)-C-x(3)-[LIVM]
STRUCTURES  PDB: 1CTU  1CTT  1ALN  1AF2  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.5
            ExPASy - ENZYME nomenclature database: 3.5.4.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.5
            BRENDA, the Enzyme Database: 3.5.4.5
            SCOP (Structural Classification of Proteins): 3.5.4.5
///
ENTRY       EC 3.5.4.6
NAME        AMP deaminase
            Adenylic acid deaminase
            AMP aminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     AMP aminohydrolase
REACTION    AMP + H2O = IMP + NH3
SUBSTRATE   AMP
            H2O
PRODUCT     IMP
            NH3
COMMENT     (cf. EC 3.5.4.17)
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       SCE: YML035C(AMD1)
            SPO: ADA1(ada1)
            CEL: C34F11.3
            MMU: 1096344(Ampd3)
            HSA: 270(AMPD1) 271(AMPD2) 272(AMPD3)
DISEASE     MIM: 102770  Adenosine monophosphate deaminase-1, muscle
            MIM: 102771  Adenosine monophosphate deaminase-2, isoform L
            MIM: 102772  Adenosine monophosphate deaminase-3, isoform E
MOTIF       PS: PS00485  [SA]-[LIVM]-[NGS]-[STA]-D-D-P
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.6
            ExPASy - ENZYME nomenclature database: 3.5.4.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.6
            BRENDA, the Enzyme Database: 3.5.4.6
///
ENTRY       EC 3.5.4.7
NAME        ADP deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     ADP aminohydrolase
REACTION    ADP + H2O = IDP + NH3
SUBSTRATE   ADP
            H2O
PRODUCT     IDP
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.7
            ExPASy - ENZYME nomenclature database: 3.5.4.7
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.7
            BRENDA, the Enzyme Database: 3.5.4.7
///
ENTRY       EC 3.5.4.8
NAME        Aminoimidazolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     4-Aminoimidazole aminohydrolase
REACTION    4-Aminoimidazole + H2O = 4-Imidazolone + NH3
SUBSTRATE   4-Aminoimidazole
            H2O
PRODUCT     NH3
            4-Imidazolone
            N-Formiminoglycine
COFACTOR    Iron
COMMENT     The product of the reaction is rapidly converted into
            formiminoglycine.  Requires Fe2+.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.8
            ExPASy - ENZYME nomenclature database: 3.5.4.8
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.8
            BRENDA, the Enzyme Database: 3.5.4.8
///
ENTRY       EC 3.5.4.9
NAME        Methenyltetrahydrofolate cyclohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     5,10-Methenyltetrahydrofolate 5-hydrolase(decyclizing)
REACTION    5,10-Methenyltetrahydrofolate + H2O = 10-Formyltetrahydrofolate
SUBSTRATE   5,10-Methenyltetrahydrofolate
            H2O
PRODUCT     10-Formyltetrahydrofolate
COMMENT     In eucaryotes occurs as a trifunctional enzyme also having
            methylenetetrahydrofolate dehydrogenase(NADP+) (EC 1.5.1.5)
            and formate--tetrahydrofolate ligase (EC 6.3.4.3) activity.
            In some procaryotes occurs as a bifunctional enzyme also
            having dehydrogenase (EC 1.5.1.5) activity or
            formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
GENES       ECO: b0529(folD)
            ECE: Z0684(folD)
            ECS: ECs0591
            YPE: YPO2824(folD)
            HIN: HI0609(folD)
            PMU: PM1933(folD)
            XFA: XF2431
            VCH: VC1942
            PAE: PA1796(folD)
            BUC: BU486(folD)
            NMA: NMA0354(folD)
            HPY: HP0577(folD)
            HPJ: jhp0524
            CJE: Cj0855(folD)
            RPR: RP515(folD)
            RCO: RC0636(folD)
            MLO: mlr6508
            SME: SMc02604(folD1) SMc03059(folD2)
            CCR: CC1217
            BSU: BG11711(folD)
            BHA: BH2784(folD)
            SAU: SA0915(folD)
            SAV: SAV1049(folD)
            LLA: L76582(folD)
            SPY: SPy1502(folD)
            SPN: SP0825
            SPR: spr0729(folD)
            CAC: CAC2083(folD)
            MGE: MG013(folD)
            MPN: D12_orf269(mtd1)
            MPU: MYPU_2580(folD)
            UUR: UU337(folD)
            MTU: Rv3356c(folD)
            MTC: MT3464
            MLE: ML0674(folD)
            CTR: CT078
            CMU: TC0350
            CPN: CPn0335
            CPA: CP0423
            CPJ: folD
            BBU: BB0026(folD)
            TPA: TP0732
            SYN: sll0753(folD)
            DRA: DR0867
            AAE: aq_1898(folD)
            TMA: TM1767
            HAL: VNG1416G(folD)
            TAC: Ta0898
            TVO: TVG1072456
            SCE: YBR084W(MIS1) YGR204W(ADE3)
            SPO: SPBC2G2.08(spbc2g2.08) SPBC839.16(spbc839.16)
            CEL: K07E3.3
            DME: CG18466(Nmdmc)
            HSA: 10797(MTHFD2) 4522(MTHFD1)
MOTIF       PS: PS00721  G-[LIVM]-K-G-G-A-A-G-G-G-Y
            PS: PS00722  V-A-T-[IV]-R-A-L-K-x-[HN]-G-G
            PS: PS00766  [EQ]-x-[EQK]-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVMY]-N-x-
                         [DN]-x(5)-[LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-[IV]
STRUCTURES  PDB: 1DIG  1DIB  1A4I  1DIA  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.9
            ExPASy - ENZYME nomenclature database: 3.5.4.9
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.9
            BRENDA, the Enzyme Database: 3.5.4.9
///
ENTRY       EC 3.5.4.10
NAME        IMP cyclohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     IMP 1,2-hydrolase (decyclizing)
REACTION    IMP + H2O =
            5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
SUBSTRATE   IMP
            H2O
PRODUCT     5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b4006(purH)
            ECE: Z5583(purH)
            ECS: ECs4929
            YPE: YPO3728(purH)
            HIN: HI0887(purH)
            PMU: PM0222(purH)
            XFA: XF1975
            VCH: VC0276
            PAE: PA4854(purH)
            BUC: BU031(purH)
            NME: NMB0983
            NMA: NMA1182(purH)
            CJE: Cj0953c(purH)
            MLO: mlr4101
            SME: SMc04088(purH)
            CCR: CC0086
            BSU: BG10710(purH)
            BHA: BH0633(purH)
            SAU: SA0925(purH)
            SAV: SAV1059(purH)
            LLA: L158710(purH)
            SPN: SP0050
            SPR: spr0051(purH)
            CAC: CAC1395(purH)
            MTU: Rv0957(purH)
            MTC: MT0984
            MLE: ML0161(purH)
            SYN: slr0597(purH)
            DRA: DR0868
            AAE: aq_1963(purH)
            TMA: TM1249
            AFU: AF1811
            HAL: VNG0414G(purH)
            TAC: Ta0060
            TVO: TVG0015470
            SCE: YLR028C(ADE16) YMR120C(ADE17)
            SPO: ADE10(ade10)
            DME: CG11089
            HSA: 471(ATIC)
STRUCTURES  PDB: 1G8M  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.10
            ExPASy - ENZYME nomenclature database: 3.5.4.10
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.10
            BRENDA, the Enzyme Database: 3.5.4.10
///
ENTRY       EC 3.5.4.11
NAME        Pterin deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     2-Amino-4-hydroxypteridine aminohydrolase
REACTION    2-Amino-4-hydroxypteridine + H2O = 2,4-Dihydroxypteridine + NH3
SUBSTRATE   2-Amino-4-hydroxypteridine
            H2O
PRODUCT     2,4-Dihydroxypteridine
            NH3
COMMENT     The animal enzyme is specific for pterin, isoxanthopterin and
            tetrahydropterin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.11
            ExPASy - ENZYME nomenclature database: 3.5.4.11
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.11
            BRENDA, the Enzyme Database: 3.5.4.11
///
ENTRY       EC 3.5.4.12
NAME        dCMP deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     dCMP aminohydrolase
REACTION    dCMP + H2O = dUMP + NH3
SUBSTRATE   dCMP
            5-Substituted dCMP
            H2O
PRODUCT     dUMP
            NH3
COMMENT     Also acts on some 5-substituted dCMPs.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       VCH: VCA0840
            BSU: BG10481(comEB)
            BHA: BH1334(comEB)
            SAU: SA1417(comEB)
            SAV: SAV1578(comEB)
            LLA: L155044(dcdA)
            SPY: SPy1823(comEB)
            SPN: SP0744
            SPR: spr0654(comEB)
            CAC: CAC2876
            MPU: MYPU_2780(dctD)
            TPA: TP0274
            DRA: DR2631
            TMA: TM0404
            AFU: AF1764
            TAC: Ta0312
            TVO: TVG1352610
            PHO: PH1589
            PAB: PAB1975
            SCE: YHR144C(DCD1)
            SPO: SPBC2G2.13C(spbc2g2.13c)
            CEL: ZK643.2
            DME: CG6951
            HSA: 1635(DCTD)
MOTIF       PS: PS00903  [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-
                         x(2,8)-C-x(3)-[LIVM]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.12
            ExPASy - ENZYME nomenclature database: 3.5.4.12
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.12
            BRENDA, the Enzyme Database: 3.5.4.12
///
ENTRY       EC 3.5.4.13
NAME        dCTP deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     dCTP aminohydrolase
REACTION    dCTP + H2O = dUTP + NH3
SUBSTRATE   dCTP
            H2O
PRODUCT     dUTP
            NH3
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2065(dcd)
            ECE: Z3233(dcd)
            ECS: ECs2872
            YPE: YPO1525(dcd)
            HIN: HI0133(dcd)
            PMU: PM0951(dcd)
            XFA: XF0762
            PAE: PA3480
            BUC: BU108(dcd)
            NME: NMB0849
            NMA: NMA1060
            HPY: HP0372(dcd)
            HPJ: jhp1009
            CJE: Cj1292(dcd)
            RPR: RP069(dcd)
            RCO: RC0099(dcd)
            SME: SMc02218
            BHA: BH0368
            CAC: CAC0025(dcd)
            MTU: Rv0321(dcd)
            MTC: MT0336
            MLE: ML2507
            CTR: CT039
            CMU: TC0309
            CPN: CPn0392
            CPA: CP0363
            CPJ: dcd
            SYN: sll1258(dcd)
            AAE: aq_1607(dcd)
            MJA: MJ0430 MJ1102(dcd)
            MTH: MTH1605 MTH1847
            AFU: AF1108
            HAL: VNG0245G(dtd) VNG2570G(dcd)
            TAC: Ta0598
            TVO: TVG0628554
            PHO: PH1997
            PAB: PAB1164(dcd)
            APE: APE0069 APE0333
            SSO: SSO0190(dcD-1) SSO2954(dcD-2)
            STO: ST0226
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.13
            ExPASy - ENZYME nomenclature database: 3.5.4.13
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.13
            BRENDA, the Enzyme Database: 3.5.4.13
///
ENTRY       EC 3.5.4.14
NAME        Deoxycytidine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Deoxycytidine aminohydrolase
REACTION    Deoxycytidine + H2O = Deoxyuridine + NH3
SUBSTRATE   Deoxycytidine
            H2O
PRODUCT     Deoxyuridine
            NH3
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.14
            ExPASy - ENZYME nomenclature database: 3.5.4.14
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.14
            BRENDA, the Enzyme Database: 3.5.4.14
///
ENTRY       EC 3.5.4.15
NAME        Guanosine deaminase
            Guanosine aminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Guanosine aminohydrolase
REACTION    Guanosine + H2O = Xanthosine + NH3
SUBSTRATE   Guanosine
            H2O
PRODUCT     Xanthosine
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.15
            ExPASy - ENZYME nomenclature database: 3.5.4.15
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.15
            BRENDA, the Enzyme Database: 3.5.4.15
///
ENTRY       EC 3.5.4.16
NAME        GTP cyclohydrolase I
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     GTP 7,8-8,9-dihydrolase
REACTION    GTP + 2 H2O = Formate + 2-Amino-4-hydroxy-6-(erythro-
            $1,2,3-trihydroxypropyl)dihydropteridine triphosphate
SUBSTRATE   GTP
            H2O
PRODUCT     Formate
            2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)
            $dihydropteridine triphosphate
COMMENT     The reaction involves hydrolysis of two C-N bonds and
            isomerization of the pentose unit; the recyclization may
            by non-enzymic.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2153(folE)
            ECE: Z3409(folE)
            ECS: ECs3045
            YPE: YPO1505(folE)
            HIN: HI1447(folE)
            PMU: PM0693(folE)
            XFA: XF1983
            VCH: VCA0616
            PAE: PA1674(folE2) PA3438(folE1)
            HPY: HP0928(folE)
            HPJ: jhp0862 jhp0863
            CJE: Cj0194(folE)
            RPR: RP383(folE)
            RCO: RC0527(folE)
            MLO: mlr0922
            SME: SMc01005(folE)
            CCR: CC0459
            BSU: BG10277(mtrA)
            BHA: BH1646(mtrA)
            LLA: L0175(folE)
            SPY: SPy1097(folE)
            SPN: SP0291
            SPR: spr0268(sulC)
            CAC: CAC3626(mtrA)
            MTU: Rv3609c(folE)
            MTC: MT3713
            MLE: ML0223(folE)
            SYN: slr0426(folE)
            DRA: DR0036
            AAE: aq_239(folE)
            SSO: SSO0364(folE)
            SCE: YGR267C(FOL2)
            SPO: SPAC17A5.13(spac17a5.13)
            CEL: F32G8.6
            DME: CG9441 Pu_1
            MMU: 95675(Gch)
            HSA: 2643(GCH1)
DISEASE     MIM: 600225  GTP cyclohydrolase 1
MOTIF       PS: PS00859  [DEN]-[LIVM](2)-x(2)-[KRNQ]-[DEN]-[LIVM]-x(3)-[ST]-x-C-
                         E-H-H
            PS: PS00860  [SA]-x-[RK]-x-Q-[LIVM]-Q-E-[RN]-[LI]-[TSN]
STRUCTURES  PDB: 1GTP  1FBX  1FB1  1A9C  1A8R  
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.16
            ExPASy - ENZYME nomenclature database: 3.5.4.16
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.16
            BRENDA, the Enzyme Database: 3.5.4.16
            SCOP (Structural Classification of Proteins): 3.5.4.16
///
ENTRY       EC 3.5.4.17
NAME        Adenosine-phosphate deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Adenosine-phosphate aminohydrolase
REACTION    AMP + H2O = IMP + NH3
SUBSTRATE   AMP
            H2O
            ADP
            ATP
            NAD+
            Adenosine
PRODUCT     IMP
            NH3
            IDP
            ITP
            Nicotinamide hypoxanthine dinucleotide
            Inosine
COMMENT     Acts on 5'-AMP, ADP, ATP, NAD+ and adenosine, in decreasing order
            of activity. The bacterial enzyme also acts on the deoxy
            derivatives. cf. EC 3.5.4.6.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.17
            ExPASy - ENZYME nomenclature database: 3.5.4.17
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.17
            BRENDA, the Enzyme Database: 3.5.4.17
///
ENTRY       EC 3.5.4.18
NAME        ATP deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     ATP aminohydrolase
REACTION    ATP + H2O = ITP + NH3
SUBSTRATE   ATP
            H2O
PRODUCT     ITP
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.18
            ExPASy - ENZYME nomenclature database: 3.5.4.18
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.18
            BRENDA, the Enzyme Database: 3.5.4.18
///
ENTRY       EC 3.5.4.19
NAME        Phosphoribosyl-AMP cyclohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     N1-(5-Phospho-D-ribosyl)-AMP 1,6-hydrolase
REACTION    N1-(5-Phospho-D-ribosyl)-AMP + H2O =
            5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-
            $imidazole-4-carboxamide
SUBSTRATE   N1-(5-Phospho-D-ribosyl)-AMP
            H2O
PRODUCT     5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-
            $imidazole-4-carboxamide
COMMENT     The Neurospora crassa enzyme also catalyses the reactions of
            EC 1.1.1.23 and 3.6.1.31.
            (EC 1.1.1.23 Histidinol dehydrogenase)
            (EC 3.6.1.31 Phosphoribosyl-ATP pyrophosphatase)
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2026(hisI)
            ECE: Z3188(hisI)
            ECS: ECs2827
            YPE: YPO1542(hisI)
            HIN: HI0475(hisI)
            PMU: PM1206(hisIE)
            XFA: XF2213
            VCH: VC1139
            PAE: PA5066(hisI)
            BUC: BU106(hisI)
            NME: NMB0627
            NMA: NMA0837(hisI)
            CJE: Cj1604(hisI)
            MLO: mlr0923
            SME: SMc01004(hisI)
            CCR: CC0457
            BSU: BG12603(hisI)
            BHA: BH3577(hisI)
            SAU: SA2464(hisI)
            SAV: SAV2657(hisI)
            LLA: L0072(hisI)
            CAC: CAC0942(hisI_1)
            MTU: Rv1606(hisI2)
            MTC: MT1641.1
            MLE: ML1264(hisI)
            SYN: slr0608(hisI)
            DRA: DR0733
            AAE: aq_1968(hisIE)
            TMA: TM1035
            MJA: MJ1430(hisIE)
            MTH: MTH245
            AFU: AF1950(hisIE)
            HAL: VNG2284G(hisJ)
            SSO: SSO6227(hisI)
            SCE: YCL030C(HIS4)
MOTIF       PS: PS00611  I-D-x(2)-A-G-P-[ST]-E-[LIVS]-[LIVMA](3)-[AC]-x(3)-A-
                         x(4)-[LIVM]-[AV]-[SACL]-[DE]-[LIVMFC]-[LIVM]-[SA]-x(2)-
                         E-H
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.19
            ExPASy - ENZYME nomenclature database: 3.5.4.19
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.19
            BRENDA, the Enzyme Database: 3.5.4.19
///
ENTRY       EC 3.5.4.20
NAME        Pyrithiamin deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     1-(4-Amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-
            $2-methylpyridinium-bromide aminohydrolase
REACTION    1-(4-Amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-
            $2-methylpyridinium bromide + H2O =
            1-(4-Hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-
            $2-methylpyridinium bromide + NH3
SUBSTRATE   1-(4-Amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-
            $2-methylpyridinium bromide
            H2O
PRODUCT     1-(4-Hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-
            $2-methylpyridinium bromide
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.20
            ExPASy - ENZYME nomenclature database: 3.5.4.20
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.20
            BRENDA, the Enzyme Database: 3.5.4.20
///
ENTRY       EC 3.5.4.21
NAME        Creatinine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Creatinine iminohydrolase
REACTION    Creatinine + H2O = N-Methylhydantoin + NH3
SUBSTRATE   Creatinine
            H2O
PRODUCT     N-Methylhydantoin
            NH3
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.21
            ExPASy - ENZYME nomenclature database: 3.5.4.21
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.21
            BRENDA, the Enzyme Database: 3.5.4.21
///
ENTRY       EC 3.5.4.22
NAME        1-Pyrroline-4-hydroxy-2-carboxylate deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     1-Pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
REACTION    1-Pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-Dioxopentanoate +
            NH3
SUBSTRATE   1-Pyrroline-4-hydroxy-2-carboxylate
            H2O
PRODUCT     2,5-Dioxopentanoate
            NH3
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.22
            ExPASy - ENZYME nomenclature database: 3.5.4.22
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.22
            BRENDA, the Enzyme Database: 3.5.4.22
///
ENTRY       EC 3.5.4.23
NAME        Blasticidin-S deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Blasticidin-S aminohydrolase
REACTION    Blasticidin S + H2O = Deaminohydroxyblasticidin S + NH3
SUBSTRATE   Blasticidin S
            H2O
            Cytomycin
            Acetylblasticidin S
PRODUCT     Deaminohydroxyblasticidin S
            NH3
COMMENT     Catalyses the deamination of the cytosine moiety of the
            antibiotics blasticidin S, cytomycin and acetylblasticidin S.
MOTIF       PS: PS00903  [CH]-[AGV]-E-x(2)-[LIVMFGAT]-[LIVM]-x(17,33)-P-C-
                         x(2,8)-C-x(3)-[LIVM]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.23
            ExPASy - ENZYME nomenclature database: 3.5.4.23
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.23
            BRENDA, the Enzyme Database: 3.5.4.23
///
ENTRY       EC 3.5.4.24
NAME        Sepiapterin deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     Sepiapterin aminohydrolase
REACTION    Sepiapterin + H2O = Xanthopterin-B2 + NH3
SUBSTRATE   Sepiapterin
            H2O
PRODUCT     Xanthopterin-B2
            NH3
COMMENT     Also acts on isosepiapterin, more slowly.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.24
            ExPASy - ENZYME nomenclature database: 3.5.4.24
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.24
            BRENDA, the Enzyme Database: 3.5.4.24
///
ENTRY       EC 3.5.4.25
NAME        GTP cyclohydrolase II
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     GTP 7,8-8,9-dihydrolase (pyrophosphate-forming)
REACTION    GTP + 3 H2O = Formate +
            2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine +
            Pyrophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     Formate
            2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine
            Pyrophosphate
COMMENT     Two C-N bonds are hydrolysed, releasing formate, with
            simultaneous removal of the terminal pyrophosphate.
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b1277(ribA)
            ECE: Z2531(ribA)
            ECS: ECs1850
            YPE: YPO2222(ribA)
            HIN: HI0212(ribA)
            PMU: PM0677(ribA)
            XFA: XF0953
            VCH: VC1263 VC2269
            PAE: PA4047(ribA) PA4054(ribB)
            BUC: BU271(ribA)
            NME: NMB1254 NMB1256
            NMA: NMA1425(ribA) NMA1429(ribB)
            HPY: HP0802(ribA) HP0804
            HPJ: jhp0738 jhp0740
            CJE: Cj0572(ribA) Cj0996(ribA)
            MLO: mlr7463
            SME: SMc00008(ribA)
            CCR: CC0887
            BSU: BG10520(ribA)
            BHA: BH1556(ribA)
            SAU: SA1587(ribA)
            SAV: SAV1753(ribA)
            LLA: L0165(ribA)
            SPN: SP0176
            SPR: spr0162(ribA)
            CAC: CAC0592(ribA)
            MTU: Rv1415(ribA2) Rv1940(ribA)
            MTC: MT1458 MT1990
            MLE: ML0559(ribA)
            CTR: CT731
            CMU: TC0104
            CPN: CPn0872
            CPA: CP0997
            CPJ: ribA_ribB
            SYN: sll1894(ribA)
            DRA: DR0155
            AAE: aq_350(ribA)
            TMA: TM1826
            AFU: AF0484(ribA-1)
            SCE: YBL033C(RIB1)
            SPO: SPAP27G11.09C(spap27g11.09c)
            ATH: At2g22450(F14M13.15)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.25
            ExPASy - ENZYME nomenclature database: 3.5.4.25
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.25
            BRENDA, the Enzyme Database: 3.5.4.25
///
ENTRY       EC 3.5.4.26
NAME        Diaminohydroxyphosphoribosylaminopyrimidine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine
            $ 2-aminohydrolase
REACTION    2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine +
            H2O = 5-Amino-6-(5'-phosphoribosylamino)uracil + NH3
SUBSTRATE   2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine
            H2O
PRODUCT     5-Amino-6-(5'-phosphoribosylamino)uracil
            NH3
COMMENT     The substrate is the product of EC 3.5.4.25.
PATHWAY     PATH: MAP00740  Riboflavin metabolism
GENES       ECO: b0414(ribD)
            ECE: Z0515(ribD)
            ECS: ECs0467
            YPE: YPO3183(ribD)
            HIN: HI0944(ribD)
            PMU: PM0749(ribD)
            XFA: XF0950
            VCH: VC2271
            PAE: PA4056(ribD)
            BUC: BU461(ribD1)
            NME: NMB1817
            NMA: NMA0644(ribD)
            HPY: HP1505(ribG)
            HPJ: jhp1398
            CJE: Cj1622(ribD)
            MLO: mlr8405
            SME: SMc01772(ribD)
            CCR: CC0885
            BSU: BG10518(ribG)
            BHA: BH1554(ribG)
            SAU: SA1589(ribD)
            SAV: SAV1755(ribD)
            LLA: L0163(ribG)
            SPN: SP0178
            SPR: spr0164(ribD)
            CAC: CAC0590(ribD)
            MTU: Rv1409(ribG)
            MTC: MT1453
            MLE: ML0555(ribG)
            CTR: CT730
            CMU: TC0103
            CPN: CPn0871
            CPA: CP0998
            CPJ: ribD
            SYN: slr0066(ribD)
            DRA: DR0153
            AAE: aq_138(ribD1)
            TMA: TM1828
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.26
            ExPASy - ENZYME nomenclature database: 3.5.4.26
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.26
            BRENDA, the Enzyme Database: 3.5.4.26
///
ENTRY       EC 3.5.4.27
NAME        Methenyltetrahydromethanopterin cyclohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     5,10-Methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
REACTION    5,10-Methenyl-5,6,7,8-tetrahydromethanopterin + H2O =
            N5-Formyl-5,6,7,8-tetrahydromethanopterin
SUBSTRATE   5,10-Methenyl-5,6,7,8-tetrahydromethanopterin
            H2O
PRODUCT     N5-Formyl-5,6,7,8-tetrahydromethanopterin
COMMENT     Methanopterin is a pterin analogue. The enzyme is involved in the
            formation of methane from CO2 in Methanobacterium
            thermoautotrophicum.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       MJA: MJ1636(mch)
            MTH: MTH773(mch)
            AFU: AF1935(mch)
            HAL: VNG1686G(mch)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.27
            ExPASy - ENZYME nomenclature database: 3.5.4.27
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.27
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.4.27
            BRENDA, the Enzyme Database: 3.5.4.27
///
ENTRY       EC 3.5.4.28
NAME        S-Adenosylhomocysteine deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In cyclic amidines
SYSNAME     S-Adenosyl-L-homocysteine aminohydrolase
REACTION    S-Adenosyl-L-homocysteine + H2O = S-Inosyl-L-homocysteine + NH3
SUBSTRATE   S-Adenosyl-L-homocysteine
            H2O
PRODUCT     S-Inosyl-L-homocysteine
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.4.28
            ExPASy - ENZYME nomenclature database: 3.5.4.28
            WIT (What Is There) Metabolic Reconstruction: 3.5.4.28
            BRENDA, the Enzyme Database: 3.5.4.28
///
ENTRY       EC 3.5.5.1
NAME        Nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     Nitrile aminohydrolase
REACTION    a Nitrile + H2O = a Carboxylate + NH3
SUBSTRATE   Nitrile
            (Indole-3-yl)acetonitrile
            H2O
            (+/-)-2-(4'-Isobutylphenyl)propionitrile
            Acid amide
PRODUCT     Carboxylate
            NH3
COMMENT     Acts on a wide range of aromatic nitriles including
            (indole-3-yl)acetonitrile, and also on some aliphatic nitriles,
            and on the corresponding acid amides. (cf. EC 4.2.1.84)
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       SCE: YJL126W(NIT2)
            CEL: ZK1058.6
MOTIF       PS: PS00920  G-x(2)-[LIVMFY](2)-x-[IF]-x-E-x(2)-[LIVM]-x-G-Y-P
            PS: PS00921  G-[GAQ]-x(2)-C-[WA]-E-[NH]-x(2)-[PST]-[LIVMFYS]-x-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.1
            ExPASy - ENZYME nomenclature database: 3.5.5.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.1
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.1
            BRENDA, the Enzyme Database: 3.5.5.1
///
ENTRY       EC 3.5.5.2
NAME        Ricinine nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     Ricinine aminohydrolase
REACTION    Ricinine + H2O = 3-Carboxy-4-methoxy-N-methyl-2-pyridone + NH3
SUBSTRATE   Ricinine
            H2O
PRODUCT     3-Carboxy-4-methoxy-N-methyl-2-pyridone
            NH3
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.2
            ExPASy - ENZYME nomenclature database: 3.5.5.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.2
            BRENDA, the Enzyme Database: 3.5.5.2
///
ENTRY       EC 3.5.5.3
NAME        Transferred to EC 4.3.99.1
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
COMMENT     Transferred entry. Now EC 4.3.99.1 - Cyanate lyase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.3
            ExPASy - ENZYME nomenclature database: 3.5.5.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.3
            BRENDA, the Enzyme Database: 3.5.5.3
///
ENTRY       EC 3.5.5.4
NAME        Cyanoalanine nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     3-Cyano-L-alanine aminohydrolase
REACTION    3-Cyano-L-alanine + 2 H2O = L-Aspartate + NH3
SUBSTRATE   3-Cyano-L-alanine
            H2O
PRODUCT     L-Aspartate
            NH3
COMMENT     L-Asparagine is formed as an intermediate.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.4
            ExPASy - ENZYME nomenclature database: 3.5.5.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.4
            BRENDA, the Enzyme Database: 3.5.5.4
///
ENTRY       EC 3.5.5.5
NAME        Arylacetonitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     Arylacetonitrile aminohydrolase
REACTION    4-Chlorophenylacetonitrile + 2 H2O = 4-Chlorophenylacetate + NH3
SUBSTRATE   4-Chlorophenylacetonitrile
            H2O
            4-Substituted phenylacetonitrile
            Thien-2-ylacetonitrile
            Tolylacetonitrile
PRODUCT     4-Chlorophenylacetate
            NH3
            4-Substituted phenylacetate
            Thien-2-ylacetate
            Tolylacetate
COFACTOR    Thiol compound
COMMENT     Requires thiol compounds. Also hydrolyses other 4-substituted
            phenylacetonitriles, thien-2-ylacetonitrile, tolylacetonitriles,
            and, more slowly, benzyl cyanide.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.5
            ExPASy - ENZYME nomenclature database: 3.5.5.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.5
            BRENDA, the Enzyme Database: 3.5.5.5
///
ENTRY       EC 3.5.5.6
NAME        Bromoxynil nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
SYSNAME     3,5-Dibromo-4-hydroxybenzonitrile aminohydrolase
REACTION    3,5-Dibromo-4-hydroxybenzonitrile + 2 H2O =
            3,5-Dibromo-4-hydroxybenzoate + NH3
SUBSTRATE   3,5-Dibromo-4-hydroxybenzonitrile
            H2O
PRODUCT     3,5-Dibromo-4-hydroxybenzoate
            NH3
COMMENT     Involved in the bacterial degradation of the herbicide bromoxynil.
            Highly specific.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.6
            ExPASy - ENZYME nomenclature database: 3.5.5.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.6
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.6
            BRENDA, the Enzyme Database: 3.5.5.6
///
ENTRY       EC 3.5.5.7
NAME        Aliphatic nitrilase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In nitriles
REACTION    R-CN + H2O = R-COOH + NH3
SUBSTRATE   R-CN
            H2O
PRODUCT     R-COOH
            NH3
COMMENT     Preferentially hydrolyses aliphatic nitriles, some of which
            are apparently not substrates for other known nitrilases
            (EC 3.5.5.1).
            Substrates include: Crotonitrile, Acrylonitrile and Glyrato-
            nitrile.
PATHWAY     PATH: MAP00643  Styrene degradation
GENES       SYN: sll0784(merR)
MOTIF       PS: PS00920  G-x(2)-[LIVMFY](2)-x-[IF]-x-E-x(2)-[LIVM]-x-G-Y-P
            PS: PS00921  G-[GAQ]-x(2)-C-[WA]-E-[NH]-x(2)-[PST]-[LIVMFYS]-x-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.5.7
            ExPASy - ENZYME nomenclature database: 3.5.5.7
            WIT (What Is There) Metabolic Reconstruction: 3.5.5.7
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.5.7
///
ENTRY       EC 3.5.99.1
NAME        Riboflavinase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     Riboflavin hydrolase
REACTION    Riboflavin + H2O = Ribitol + Lumichrome
SUBSTRATE   Riboflavin
            H2O
PRODUCT     Ribitol
            Lumichrome
PATHWAY     PATH: MAP00740  Riboflavin metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.1
            ExPASy - ENZYME nomenclature database: 3.5.99.1
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.1
            BRENDA, the Enzyme Database: 3.5.99.1
///
ENTRY       EC 3.5.99.2
NAME        Thiaminase
            Thiaminase II
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     Thiamin hydrolase
REACTION    Thiamine + H2O = 4-Amino-5-hydroxymethyl-2-methylpyrimidine +
            5-(2-Hydroxyethyl)-4-methylthiazole
SUBSTRATE   Thiamine
            H2O
PRODUCT     4-Amino-5-hydroxymethyl-2-methylpyrimidine
            5-(2-Hydroxyethyl)-4-methylthiazole
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.2
            ExPASy - ENZYME nomenclature database: 3.5.99.2
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.2
            BRENDA, the Enzyme Database: 3.5.99.2
///
ENTRY       EC 3.5.99.3
NAME        Hydroxydechloroatrazine ethylaminohydrolase
            AtzB
            Hydroxyatrazine ethylaminohydrolase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     4-(Ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine
            ethylaminohydrolase
REACTION    4-(Ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O =
            N-Isopropylammelide + Ethylamine
SUBSTRATE   4-(Ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine
            H2O
PRODUCT     N-Isopropylammelide
            Ethylamine
COMMENT     Involved in a pathway by which the herbicide atrazine, 2-chloro-4-
            (ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in
            bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-
            1,3,5-triazine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.3
            ExPASy - ENZYME nomenclature database: 3.5.99.3
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.3
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.99.3
///
ENTRY       EC 3.5.99.4
NAME        N-Isopropylammelide isopropylaminohydrolase
            AtzC
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     N-Isopropylammelide isopropylaminohydrolase
REACTION    N-Isopropylammelide + H2O = Cyanuric acid + Isopropylamine
SUBSTRATE   N-Isopropylammelide
            H2O
PRODUCT     Cyanuric acid
            Isopropylamine
COMMENT     Involved in a pathway by which the herbicide atrazine, 2-chloro-4-
            (ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in
            bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-
            1,3,5-triazine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.4
            ExPASy - ENZYME nomenclature database: 3.5.99.4
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.4
            UM-BBD (Biocatalysis/Biodegradation Database): 3.5.99.4
///
ENTRY       EC 3.5.99.5
NAME        2-Aminomuconate deaminase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     2-Aminomuconate aminohydrolase
REACTION    2-Aminomuconate + H2O = 4-Oxalocrotonate + NH3
SUBSTRATE   2-Aminomuconate
            H2O
PRODUCT     4-Oxalocrotonate
            NH3
COMMENT     Intermediate in the biodegradation of nitrobenzene by Pseudomonas
            pseudocaligenes JS45. The reaction is spontaneous in acid
            conditions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.5
            ExPASy - ENZYME nomenclature database: 3.5.99.5
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.5
///
ENTRY       EC 3.5.99.6
NAME        Glucosamine-6-phosphate deaminase
            Glucosaminephosphate isomerase
            Glucosamine-6-phosphate isomerase
CLASS       Hydrolases
            Acting on carbon-nitrogen bonds, other than peptide bonds
            In other compounds
SYSNAME     2-Amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol
            isomerizing)
REACTION    D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3
SUBSTRATE   D-Glucosamine 6-phosphate
            H2O
PRODUCT     D-Fructose 6-phosphate
            NH3
EFFECTOR    N-Acetyl-D-glucosamine 6-phosphate
COMMENT     Formerly EC 5.3.1.10. Isomerization of the aldose-ketose type
            converts the -CH(-NH2)-CH=O group of glucosamine 6-phosphate into 
            -C(=NH)-CH2-OH, forming 2-deoxy-2-imino-D-arabino-hexitol, which
            then hydrolyses to yield fructose 6-phosphate and ammonia. N-
            Acetyl-D-glucosamine 6-phosphate, which is not broken down,
            activates the enzyme.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b0678(nagB)
            ECE: Z0825(nagB)
            ECS: ECs0708
            HIN: HI0141(nagB)
            PMU: PM0875(nagB)
            VCH: VCA1025
            BSU: BG12631(nagB) BG12746(gamA)
            BHA: BH0420(nagB)
            SAU: SA0527(nagB)
            SAV: SAV0558(nagB)
            LLA: L14408(nagB)
            SPY: SPy1399(nagB)
            SPN: SP1415
            SPR: spr1272(nagB)
            CAC: CAC0187(nagB)
            MPU: MYPU_3620(nagB)
            BBU: BB0152(nagB)
            CEL: T03F6.3
            DME: CG6957
            HSA: 10007(GNPI)
DBLINKS     IUBMB Enzyme Nomenclature: 3.5.99.6
            ExPASy - ENZYME nomenclature database: 3.5.99.6
            WIT (What Is There) Metabolic Reconstruction: 3.5.99.6
///
ENTRY       EC 3.6.1.1
NAME        Inorganic pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Pyrophosphate phosphohydrolase
REACTION    Pyrophosphate + H2O = 2 Orthophosphate
SUBSTRATE   Pyrophosphate
            H2O
PRODUCT     Orthophosphate
COFACTOR    Metal
COMMENT     Specificity varies with the source and with the activating metal
            ion. The enzyme from some sources may be identical with
            EC 3.1.3.1. or 3.1.3.9.
            (EC 3.1.3.1 Alkaline phosphatase)
            (EC 3.1.3.9 Glucose-6-phophatase)
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
GENES       ECO: b4226(ppa)
            ECE: Z5837(ppa)
            ECS: ECs5204
            YPE: YPO3521(ppa)
            HIN: HI0124(ppa)
            PMU: PM1191(ppa)
            XFA: XF2171
            VCH: VC2545
            PAE: PA4031
            BUC: BU088(ppa)
            NME: NMB0641
            NMA: NMA0851(ppa)
            HPY: HP0620(ppa)
            HPJ: jhp0564
            CJE: Cj0638c(ppa)
            RPR: RP589(ppa)
            RCO: RC0897(ppa)
            MLO: mll4120 mlr8562
            SME: SMc03239(ppa)
            CCR: CC0047
            BSU: BG10014(ppaC)
            BHA: BH1604
            SAU: SA1735
            SAV: SAV1904
            LLA: L62663(yshC)
            SPY: SPy0380
            SPN: SP1534
            CAC: CAC2138
            MGE: MG351(ppa)
            MPN: G12_orf184(ppa)
            MPU: MYPU_4700(ppa)
            UUR: UU315(ppa)
            MTU: Rv3628(ppa)
            MTC: MT3730
            MLE: ML0210(ppa)
            CTR: CT772
            CMU: TC0153
            CPN: CPn0918
            CPA: CP0948
            CPJ: ppa
            SYN: slr1622(ppa)
            DRA: DR2576
            AAE: aq_1547(ppa)
            TMA: TM0174 TM0587
            MJA: MJ0608
            MTH: MTH263
            AFU: AF0756(ppx1)
            HAL: VNG0259G(ipp)
            TAC: Ta0399
            TVO: TVG1246465
            PHO: PH1907
            PAB: PAB1104(ppa)
            APE: APE1692
            SSO: SSO2390(ppa)
            STO: ST0524
            SCE: YBR011C(IPP1) YMR267W(PPA2)
            SPO: PPA1_2(ppa1) SPAC3A12.02(spac3a12.02)
            ATH: At1g78920(F9K20.2) At2g18230(T30D6.26)
            CEL: C47E12.4
            DME: CG4634(Nurf-38)
            MMU: 97831(Pyp)
            HSA: 5464
MOTIF       PS: PS00387  D-[SGDN]-D-[PE]-[LIVMF]-D-[LIVMGAC]
STRUCTURES  PDB: 8PRK  117E  1E6A  1E9G  1FAJ  1HUJ  1HUK  1I74  1IGP  1INO  
                 1IPW  1JFD  1MJW  1MJX  1MJY  1MJZ  1OBW  1PYP  1QEZ  1WGI  
                 1WGJ  1YPP  2EIP  2PRD  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.1
            ExPASy - ENZYME nomenclature database: 3.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.1
            BRENDA, the Enzyme Database: 3.6.1.1
            SCOP (Structural Classification of Proteins): 3.6.1.1
///
ENTRY       EC 3.6.1.2
NAME        Trimetaphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Trimetaphosphate hydrolase
REACTION    Trimetaphosphate + H2O = Triphosphate
SUBSTRATE   Trimetaphosphate
            H2O
PRODUCT     Triphosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.2
            ExPASy - ENZYME nomenclature database: 3.6.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.2
            BRENDA, the Enzyme Database: 3.6.1.2
///
ENTRY       EC 3.6.1.3
NAME        Adenosinetriphosphatase
            Adenylpyrophosphatase
            ATP monophosphatase
            Triphosphatase
            ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Many enzymes previously listed under this number are now listed
            separately as EC 3.6.1.32-39. The remaining enzymes, not
            separately listed on the basis of some function coupled with
            hydrolysis of ATP, include enzymes dependent on Ca2+, Mg2+,
            anions, H+ or DNA.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       DME: CG2331(TER94) CG2331_1(TER94) CG3736(okr) CG4147(Hsc70-3)
                 CG4152 CG4261(Hel89B) CG4264(Hsc70-4) CG8103(Mi-2)
                 CG8571(smid) CG8625(Iswi) CG8937(Hsc70-1)
            MMU: 88114(Atp4b)
STRUCTURES  PDB: 3HSC  1NGF  1NGE  1NGD  1NGC  1NGB  1NGA  1KAZ  1KAY  1KAX  
                 1HQC  1HPM  1HJO  1BA1  1BA0  1ATS  1ATR  1NGG  1NGJ  1NGH  
                 1NGI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.3
            ExPASy - ENZYME nomenclature database: 3.6.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.3
            BRENDA, the Enzyme Database: 3.6.1.3
            SCOP (Structural Classification of Proteins): 3.6.1.3
///
ENTRY       EC 3.6.1.4
NAME        Deleted entry
            Adenosinetriphosphatase (Mg-activated)
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
COMMENT     Deleted entry. Now included with EC 3.6.1.3.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.4
            ExPASy - ENZYME nomenclature database: 3.6.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.4
///
ENTRY       EC 3.6.1.5
NAME        Apyrase
            ATP-diphosphatase
            Adenosine diphosphatase
            ADPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP diphosphohydrolase
REACTION    ATP + 2 H2O = AMP + 2 Orthophosphate
SUBSTRATE   ATP
            H2O
            ADP
PRODUCT     AMP
            Orthophosphate
COFACTOR    Calcium
COMMENT     Requires Ca2+. Also acts on ADP, and on other nucleoside
            triphosphates and diphosphates.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       SCE: YER005W(YND1)
            HSA: 953(ENTPD1)
MOTIF       PS: PS00785  [LIVM]-x-[LIVM](2)-[HEA]-[TI]-x-D-x-H-[GSA]-x-[LIVMF]
            PS: PS00786  [FYP]-x(4)-[LIVM]-G-N-H-E-F-[DN]
            PS: PS01238  [LIVM]-x-G-x(2)-E-G-x-[FY]-x-[FW]-[LIVA]-[TAG]-x-N-[HY]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.5
            ExPASy - ENZYME nomenclature database: 3.6.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.5
            BRENDA, the Enzyme Database: 3.6.1.5
///
ENTRY       EC 3.6.1.6
NAME        Nucleoside-diphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Nucleoside-diphosphate phosphohydrolase
REACTION    a Nucleoside diphosphate + H2O = a Nucleotide + Orthophosphate
SUBSTRATE   Nucleoside diphosphate
            H2O
            IDP
            GDP
            UDP
            D-Ribose 5-diphosphate
PRODUCT     Nucleotide
            Orthophosphate
            IMP
            GMP
            UMP
            D-Ribose 5-phosphate
COMMENT     Acts on IDP, GDP, UDP and also on D-ribose 5-diphosphate.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.6
            ExPASy - ENZYME nomenclature database: 3.6.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.6
            BRENDA, the Enzyme Database: 3.6.1.6
///
ENTRY       EC 3.6.1.7
NAME        Acylphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Acylphosphate phosphohydrolase
REACTION    an Acyl phosphate + H2O = a Carboxylate + Orthophosphate
SUBSTRATE   Acyl phosphate
            H2O
PRODUCT     Carboxylate
            Orthophosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0968(yccX)
            ECE: Z1320
            ECS: ECs1052
            PMU: PM0396
            VCH: VC1355
            PAE: PA0954
            MLO: mll7735
            BSU: BG12947(yflL)
            SAU: SA1236
            SAV: SAV1389
            LLA: L196178(yfjC)
            SPY: SPy0352
            SPN: SP1974
            SPR: spr1789(acyP)
            CAC: CAC2830
            MTC: MT2991
            BBU: BBB01
            DRA: DR0929
            TMA: TM1564
            AFU: AF0818(acyP)
            TAC: Ta0064
            TVO: TVG0019502
            PAB: PAB7421(acyP)
            APE: APE1591
            SSO: SSO0887
            STO: STS137
            DME: CG14022 CG16870(Acyp) CG18371 CG18505
            HSA: 97(ACYP1) 98(ACYP2)
DISEASE     MIM: 600875  Acylphosphatase, erythrocyte
MOTIF       PS: PS00150  [LIV]-x-G-x-V-Q-G-V-x-[FM]-R
            PS: PS00151  G-[FYW]-[AVC]-[KRQAM]-N-x(3)-G-x-V-x(5)-G
STRUCTURES  PDB: 2ACY  1APS  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.7
            ExPASy - ENZYME nomenclature database: 3.6.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.7
            BRENDA, the Enzyme Database: 3.6.1.7
            SCOP (Structural Classification of Proteins): 3.6.1.7
///
ENTRY       EC 3.6.1.8
NAME        ATP pyrophosphatase
            ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP pyrophosphohydrolase
REACTION    ATP + H2O = AMP + Pyrophosphate
SUBSTRATE   ATP
            H2O
            ITP
            GTP
            CTP
            UTP
PRODUCT     AMP
            Pyrophosphate
            IMP
            GMP
            CMP
            UMP
COMMENT     Also acts on ITP, GTP, CTP and UTP.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.8
            ExPASy - ENZYME nomenclature database: 3.6.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.8
            BRENDA, the Enzyme Database: 3.6.1.8
///
ENTRY       EC 3.6.1.9
NAME        Nucleotide pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Dinucleotide nucleotidohydrolase
REACTION    a Dinucleotide + H2O = 2 Mononucleotide
SUBSTRATE   Dinucleotide
            H2O
            NAD+
            NADP+
            FAD
            CoA
            ATP
            ADP
PRODUCT     Mononucleotide
            AMP
            NMN
            AMP 2'-phosphate
            FMN
            AMP 3'-phosphate
            D-Pantetheine 4'-phosphate
            Pyrophosphate
            Orthophosphate
COMMENT     Substrates include NAD+, NADP+, FAD, CoA and also ATP and ADP.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00740  Riboflavin metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       MMU: 97370(Pdnp1)
            HSA: 5167(ENPP1) 5168(ENPP2) 5169(ENPP3)
DISEASE     MIM: 162150  Proprotein convertase subtilisin/kexin type 1
MOTIF       PS: PS00524  C-x-C-x(3)-C-x(5)-C-C-x-[DN]-[FY]-x(3)-C
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.9
            ExPASy - ENZYME nomenclature database: 3.6.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.9
            BRENDA, the Enzyme Database: 3.6.1.9
///
ENTRY       EC 3.6.1.10
NAME        Endopolyphosphatase
            Polyphosphate depolymerase
            Metaphosphatase
            Polyphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Polyphosphate polyphosphohydrolase
REACTION    Polyphosphate + n H2O = (n+1) Oligophosphate
SUBSTRATE   Polyphosphate
            H2O
PRODUCT     Oligophosphate
COMMENT     The product contains 4 or 5 phosphate residues.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.10
            ExPASy - ENZYME nomenclature database: 3.6.1.10
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.10
            BRENDA, the Enzyme Database: 3.6.1.10
///
ENTRY       EC 3.6.1.11
NAME        Exopolyphosphatase
            Metaphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Polyphosphate phosphohydrolase
REACTION    (Polyphosphate)n + H2O = (Polyphosphate)n-1 + Orthophosphate
SUBSTRATE   (Polyphosphate)n
            H2O
PRODUCT     (Polyphosphate)n-1
            Orthophosphate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2502(ppx)
            ECE: Z3765(ppx)
            ECS: ECs3364
            YPE: YPO2837(ppx)
            HIN: HI0695(ppx)
            PMU: PM1807
            XFA: XF2590
            VCH: VC0722
            PAE: PA5241(ppx)
            NME: NMB1467
            NMA: NMA1679(ppx/gppA)
            HPY: HP0278(gppA)
            HPJ: jhp0263
            CJE: Cj0353c
            RCO: RC0392(gppA)
            MLO: mlr8162
            BHA: BH1393
            CAC: CAC0621
            SYN: sll1546(ppx)
            DRA: DRA0185
            AAE: aq_891(ppx)
            TMA: TM0195
            SSO: SSO1193
            SCE: YHR201C(PPX1)
            SPO: SPAC2F3.11(spac2f3.11)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.11
            ExPASy - ENZYME nomenclature database: 3.6.1.11
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.11
            BRENDA, the Enzyme Database: 3.6.1.11
///
ENTRY       EC 3.6.1.12
NAME        dCTP pyrophosphatase
            Deoxycytidine-triphosphatase
            dCTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     dCTP nucleotidohydrolase
REACTION    dCTP + H2O = dCMP + Pyrophosphate;
            dCDP + H2O = dCMP + Orthophosphate
SUBSTRATE   dCTP
            H2O
            dCDP
PRODUCT     dCMP
            Pyrophosphate
            Orthophosphate
COMMENT     Also hydrolyses dCDP to dCMP and orthophosphate.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.12
            ExPASy - ENZYME nomenclature database: 3.6.1.12
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.12
            BRENDA, the Enzyme Database: 3.6.1.12
///
ENTRY       EC 3.6.1.13
NAME        ADPribose pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ADPribose ribophosphohydrolase
REACTION    ADPribose + H2O = AMP + D-Ribose 5-phosphate
SUBSTRATE   ADPribose
            H2O
PRODUCT     AMP
            D-Ribose 5-phosphate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3034(yqiE)
            ECE: Z4391(yqiE)
            ECS: ECs3922
            HIN: HI0398
            PMU: PM1020
            VCH: VC2435
            PAE: PA4971
            BSU: BG11762(nudF)
            BHA: BH1524
            SAU: SA1330
            SAV: SAV1488
            LLA: L133761(ytfB)
            SPY: SPy0444
            TMA: TM1181
            MJA: MJ1149(mutT)
            SCE: YBR111C(YSA1)
            CEL: W02G9.1
            HSA: 11164(NUDT5)
STRUCTURES  PDB: 1G0S  1G9Q  1GA7  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.13
            ExPASy - ENZYME nomenclature database: 3.6.1.13
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.13
            BRENDA, the Enzyme Database: 3.6.1.13
///
ENTRY       EC 3.6.1.14
NAME        Adenosine-tetraphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Adenosine-tetraphosphate phosphohydrolase
REACTION    Adenosine 5'-tetraphosphate + H2O = ATP + Orthophosphate
SUBSTRATE   Adenosine 5'-tetraphosphate
            H2O
            Inosine 5'-tetraphosphate
            Inosine tripolyphosphate
PRODUCT     ATP
            Orthophosphate
            ITP
COMMENT     Also acts on inosine tetraphosphate and tripolyphosphate
            but shows little or no activity with other nucleotides or
            polyphosphates.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.14
            ExPASy - ENZYME nomenclature database: 3.6.1.14
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.14
            BRENDA, the Enzyme Database: 3.6.1.14
///
ENTRY       EC 3.6.1.15
NAME        Nucleoside-triphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Unspecific diphosphate phosphohydrolase
REACTION    NTP + H2O = NDP + Orthophosphate
SUBSTRATE   NTP
            NDP
            Thiamine diphosphate
            FAD
            H2O
PRODUCT     NDP
            NMP
            Thiamine monophosphate
            FMN
            Orthophosphate
COMMENT     Also hydrolyses other nucleoside triphosphates, diphosphates,
            thiamine diphosphate and FAD
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00730  Thiamine metabolism
GENES       MJA: MJ0226
MOTIF       PS: PS01238  [LIVM]-x-G-x(2)-E-G-x-[FY]-x-[FW]-[LIVA]-[TAG]-x-N-[HY]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.15
            ExPASy - ENZYME nomenclature database: 3.6.1.15
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.15
            BRENDA, the Enzyme Database: 3.6.1.15
///
ENTRY       EC 3.6.1.16
NAME        CDPglycerol pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     CDPglycerol phosphoglycerohydrolase
REACTION    CDPglycerol + H2O = CMP + sn-Glycerol 3-phosphate
SUBSTRATE   CDPglycerol
            H2O
PRODUCT     CMP
            sn-Glycerol 3-phosphate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       CEL: ZK637.5
            HSA: 439(ASNA1)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.16
            ExPASy - ENZYME nomenclature database: 3.6.1.16
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.16
            BRENDA, the Enzyme Database: 3.6.1.16
///
ENTRY       EC 3.6.1.17
NAME        Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
            Bis(5'-guanosyl)-tetraphosphatase
            Bis(5'-adenosyl)-tetraphosphatase
            Diguanosinetetraphosphatase (asymmetrical)
            Dinucleosidetetraphosphatase (asymmetrical)
            Diadenosine P1,P4-tetraphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     P1,P4-Bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
REACTION    P1,P4-Bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP
SUBSTRATE   P1,P4-Bis(5'-guanosyl) tetraphosphate
            H2O
            P1,P4-Bis(5'-xanthosyl) tetraphosphate
PRODUCT     GTP
            GMP
            XTP
            XMP
COMMENT     Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly,
            on bis(5'-adenosyl)-tetraphosphate and
            bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       SPO: APH1(aph1)
            HSA: 318(NUDT2)
MOTIF       PS: PS00892  [NQA]-x(4)-[GSAV]-x-[QF]-x-[LIVM]-x-H-[LIVMFYST]-H-
                         [LIVMFT]-H-[LIVMF](2)-[PSGA]
            PS: PS00893  G-x(5)-E-x(4)-[TAGCV]-[LIVMAC]-x-R-E-[LIVMFGSTA]-x-E-E-
                         x-[GNDTHR]
STRUCTURES  PDB: 1F3Y  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.17
            ExPASy - ENZYME nomenclature database: 3.6.1.17
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.17
            BRENDA, the Enzyme Database: 3.6.1.17
///
ENTRY       EC 3.6.1.18
NAME        FAD pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     FAD nucleotidohydrolase
REACTION    FAD + H2O = AMP + FMN
SUBSTRATE   FAD
            H2O
PRODUCT     AMP
            FMN
COMMENT     The plant enzyme also hydrolyses NAD+ and NADH; the animal enzyme
            hydrolyses NAD and CoA at about half of the rate of hydrolysis of
            FAD. May be identical with EC 3.6.1.9.
PATHWAY     PATH: MAP00740  Riboflavin metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.18
            ExPASy - ENZYME nomenclature database: 3.6.1.18
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.18
            BRENDA, the Enzyme Database: 3.6.1.18
///
ENTRY       EC 3.6.1.19
NAME        Nucleoside-triphosphate pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Nucleoside-triphosphate pyrophosphohydrolase
REACTION    a Nucleoside triphosphate + H2O = a Nucleotide + Pyrophosphate
SUBSTRATE   Nucleoside triphosphate
            H2O
PRODUCT     Nucleotide
            Pyrophosphate
COMMENT     May be identical with EC 3.6.1.9.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00240  Pyrimidine metabolism
GENES       HSA: 3704(ITPA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.19
            ExPASy - ENZYME nomenclature database: 3.6.1.19
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.19
            BRENDA, the Enzyme Database: 3.6.1.19
///
ENTRY       EC 3.6.1.20
NAME        5'-Acylphosphoadenosine hydrolase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     5'-Acylphosphoadenosine acylhydrolase
REACTION    5'-Acylphosphoadenosine + H2O = AMP + a Carboxylate
SUBSTRATE   5'-Acylphosphoadenosine
            H2O
            5'-Acylphosphoinosine
            5'-Acylphosphouridine
PRODUCT     AMP
            Carboxylate
            IMP
            UMP
COMMENT     Also acts on inosine and uridine compounds.
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.20
            ExPASy - ENZYME nomenclature database: 3.6.1.20
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.20
            BRENDA, the Enzyme Database: 3.6.1.20
///
ENTRY       EC 3.6.1.21
NAME        ADPsugar pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ADPsugar sugarphosphohydrolase
REACTION    ADPsugar + H2O = AMP + Sugar 1-phosphate
SUBSTRATE   ADPsugar
            H2O
PRODUCT     AMP
            Sugar 1-phosphate
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00230  Purine metabolism
            PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.21
            ExPASy - ENZYME nomenclature database: 3.6.1.21
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.21
            BRENDA, the Enzyme Database: 3.6.1.21
///
ENTRY       EC 3.6.1.22
NAME        NAD+ pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     NAD+ phosphohydrolase
REACTION    NAD+ + H2O = AMP + NMN
SUBSTRATE   NAD+
            H2O
            NADP+
PRODUCT     AMP
            NMN
            AMP 2'-phosphate
COMMENT     Also acts on NADP+, 3-acetylpyridine and the thionicotinamide
            analogues of NAD+ and NADP+.
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.22
            ExPASy - ENZYME nomenclature database: 3.6.1.22
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.22
            BRENDA, the Enzyme Database: 3.6.1.22
///
ENTRY       EC 3.6.1.23
NAME        dUTP pyrophosphatase
            Deoxyuridine-triphosphatase
            dUTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     dUTP nucleotidohydrolase
REACTION    dUTP + H2O = dUMP + Pyrophosphate
SUBSTRATE   dUTP
            H2O
PRODUCT     dUMP
            Pyrophosphate
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b3640(dut)
            ECE: Z5064(dut)
            ECS: ECs4515
            YPE: YPO0047(dut)
            HIN: HI0954(dut)
            PMU: PM1154(dut)
            XFA: XF0150
            PAE: PA5321(dut)
            BUC: BU560(dut)
            NME: NMB0893
            NMA: NMA1112(dut)
            HPY: HP0865(dut)
            HPJ: jhp0799
            RPR: RP399(dut)
            RCO: RC0546(dut)
            MLO: mll5345
            SME: SMc00461(dnaS)
            CCR: CC3713
            BSU: BG13437(dut) BG13728(yosS)
            LLA: L181168(dut) L42912(pi335) L48154(pi221) L58858(pi120)
            SPY: SPy0235
            SPN: SP0021
            SPR: spr0023(dut)
            CAC: CAC1210(dut) CAC1425
            MTU: Rv2697c(dut)
            MTC: MT2771
            MLE: ML1028(dut)
            CTR: CT292
            CMU: TC0565
            CPN: CPn0059
            CPA: CP0716
            CPJ: dut
            TPA: TP0885
            AAE: aq_220(dut)
            SCE: YBR252W(DUT1)
            SPO: SPAC644.05C(spac644.05c)
            DME: CG4584(BcDNA:LD08534)
            HSA: 1854(DUT)
DISEASE     MIM: 601266  dUTP pyrophosphatase
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
STRUCTURES  PDB: 1F7P  1F7O  1F7N  1F7K  1F7D  1EU5  1F7Q  1DUP  1DUN  1DUD  
                 1DUC  1F7R  1DUT  1EUW  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.23
            ExPASy - ENZYME nomenclature database: 3.6.1.23
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.23
            BRENDA, the Enzyme Database: 3.6.1.23
            SCOP (Structural Classification of Proteins): 3.6.1.23
///
ENTRY       EC 3.6.1.24
NAME        Nucleoside phosphoacylhydrolase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Nucleoside-5'-phosphoacylate acylhydrolase
REACTION    Hydrolyses mixed phospho-anhydride bonds
SUBSTRATE   Nucleoside 5'-phosphoacylate
            H2O
PRODUCT     Nucleoside 5'-phosphate
            Carboxylate
COMMENT     Attacks ribonucleoside 5'-nitrophenylphosphates, but is inactive
            against phosphodiesters.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.24
            ExPASy - ENZYME nomenclature database: 3.6.1.24
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.24
            BRENDA, the Enzyme Database: 3.6.1.24
///
ENTRY       EC 3.6.1.25
NAME        Triphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Triphosphate phosphohydrolase
REACTION    Triphosphate + H2O = Pyrophosphate + Orthophosphate
SUBSTRATE   Triphosphate
            H2O
PRODUCT     Pyrophosphate
            Orthophosphate
PATHWAY     PATH: MAP00271  Methionine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.25
            ExPASy - ENZYME nomenclature database: 3.6.1.25
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.25
            BRENDA, the Enzyme Database: 3.6.1.25
///
ENTRY       EC 3.6.1.26
NAME        CDPdiacylglycerol pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     CDPdiacylglycerol phosphatidylhydrolase
REACTION    CDPdiacylglycerol + H2O = CMP + Phosphatidate
SUBSTRATE   CDPdiacylglycerol
            H2O
PRODUCT     CMP
            Phosphatidate
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b3918(cdh)
            ECE: Z5463(cdh)
            ECS: ECs4843
            YPE: YPO3986(cdh)
            HPY: HP0871(cdh)
            HPJ: jhp0805
            MTU: Rv2289(cdh)
            MTC: MT2346
            MLE: ML1417
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.26
            ExPASy - ENZYME nomenclature database: 3.6.1.26
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.26
            BRENDA, the Enzyme Database: 3.6.1.26
///
ENTRY       EC 3.6.1.27
NAME        Undecaprenyl-diphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Undecaprenyl-diphosphate phosphohydrolase
REACTION    Undecaprenyl diphosphate + H2O = Undecaprenyl phosphate +
            Orthophosphate
SUBSTRATE   Undecaprenyl diphosphate
            H2O
PRODUCT     Undecaprenyl phosphate
            Orthophosphate
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.27
            ExPASy - ENZYME nomenclature database: 3.6.1.27
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.27
            BRENDA, the Enzyme Database: 3.6.1.27
///
ENTRY       EC 3.6.1.28
NAME        Thiamin-triphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Thiamin-triphosphate phosphohydrolase
REACTION    Thiamine triphosphate + H2O = Thiamine diphosphate + Orthophosphate
SUBSTRATE   Thiamine triphosphate
            H2O
PRODUCT     Thiamine diphosphate
            Orthophosphate
PATHWAY     PATH: MAP00730  Thiamine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.28
            ExPASy - ENZYME nomenclature database: 3.6.1.28
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.28
            BRENDA, the Enzyme Database: 3.6.1.28
///
ENTRY       EC 3.6.1.29
NAME        Bis(5'-adenosyl)-triphosphatase
            Dinucleosidetriphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     P1,P2-Bis(5'-adenosyl)-triphosphate adenylohydrolase
REACTION    P1,P2-Bis(5'-adenosyl) triphosphate + H2O = ADP + AMP
SUBSTRATE   P1,P2-Bis(5'-adenosyl) triphosphate
            H2O
PRODUCT     ADP
            AMP
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       HSA: 2272(FHIT)
MOTIF       PS: PS00892  [NQA]-x(4)-[GSAV]-x-[QF]-x-[LIVM]-x-H-[LIVMFYST]-H-
                         [LIVMFT]-H-[LIVMF](2)-[PSGA]
STRUCTURES  PDB: 5FIT  4FIT  1FHI  6FIT  2FHI  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.29
            ExPASy - ENZYME nomenclature database: 3.6.1.29
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.29
            BRENDA, the Enzyme Database: 3.6.1.29
            SCOP (Structural Classification of Proteins): 3.6.1.29
///
ENTRY       EC 3.6.1.30
NAME        m(7)G(5')pppN pyrophosphatase
            Decapase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     7-Methylguanosine-5'-phosphohydrolase
REACTION    7-Methylguanosine 5'-triphospho-5'-polynucleotide + H2O =
            7-Methylguanosine 5'-phosphate + Polynucleotide
SUBSTRATE   7-Methylguanosine 5'-triphospho-5'-polynucleotide
            H2O
PRODUCT     7-Methylguanosine 5'-phosphate
            Polynucleotide
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.30
            ExPASy - ENZYME nomenclature database: 3.6.1.30
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.30
            BRENDA, the Enzyme Database: 3.6.1.30
///
ENTRY       EC 3.6.1.31
NAME        Phosphoribosyl-ATP pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Phosphoribosyl-ATP pyrophosphohydrolase
REACTION    Phosphoribosyl-ATP + H2O = Phosphoribosyl-AMP + Pyrophosphate
SUBSTRATE   Phosphoribosyl-ATP
            H2O
PRODUCT     Phosphoribosyl-AMP
            Pyrophosphate
COFACTOR    H+
COMMENT     The Neurospora crassa enzyme also catalyses the reactions of
            EC 1.1.1.23 and 3.5.4.19.
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2026(hisI)
            ECE: Z3188(hisI)
            ECS: ECs2827
            YPE: YPO1542(hisI)
            HIN: HI0475(hisI)
            PMU: PM1206(hisIE)
            XFA: XF2213
            VCH: VC1139
            PAE: PA5067(hisE)
            BUC: BU106(hisI)
            NME: NMB0603
            NMA: NMA0807(hisE)
            CJE: Cj1604(hisI)
            MLO: mlr5018
            SME: SMc02568(hisE)
            CCR: CC3738
            BSU: BG12603(hisI)
            BHA: BH3577(hisI)
            SAU: SA2464(hisI)
            SAV: SAV2657(hisI)
            LLA: L0072(hisI)
            CAC: CAC0943(his_2)
            MTU: Rv2122c(hisI)
            MTC: MT2182
            MLE: ML1309(hisE)
            SYN: slr0608(hisI)
            DRA: DR0733
            AAE: aq_1968(hisIE)
            TMA: TM1035
            MJA: MJ0302(hisE)
            MTH: MTH1283
            HAL: VNG2596G(hisI)
            SSO: SSO6223(hisE)
            SCE: YCL030C(HIS4)
MOTIF       PS: PS00611  I-D-x(2)-A-G-P-[ST]-E-[LIVS]-[LIVMA](3)-[AC]-x(3)-A-
                         x(4)-[LIVM]-[AV]-[SACL]-[DE]-[LIVMFC]-[LIVM]-[SA]-x(2)-
                         E-H
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.31
            ExPASy - ENZYME nomenclature database: 3.6.1.31
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.31
            BRENDA, the Enzyme Database: 3.6.1.31
///
ENTRY       EC 3.6.1.32
NAME        Myosin ATPase
            Actomyosin
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Myosin ATP phosphohydrolase (actin-translocating)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    Calcium
COMMENT     Involved in muscle contraction. In the absence of actin, myosin
            shows only low ATPase activity, which requires Ca2+.
            Formerly included with EC 3.6.1.3.
PATHWAY     PATH: MAP00230  Purine metabolism
STRUCTURES  PDB: 1BR2  1BR4  1I84  1MMA  1MMD  1MMG  1MMN  1MND  1MNE  1BR1  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.32
            ExPASy - ENZYME nomenclature database: 3.6.1.32
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.32
            BRENDA, the Enzyme Database: 3.6.1.32
            SCOP (Structural Classification of Proteins): 3.6.1.32
///
ENTRY       EC 3.6.1.33
NAME        Dynein ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Dynein ATP phosphohydrolase (tubulin-translocating)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     This protein forms the dynein arms that link the microtubules of
            cilia and induce their relative motion. The intrinsic ATPase
            activity of dynein is much higher than that of myosin, and is only
            increased by 30% by interaction with tubulin.
            Formerly included with EC 3.6.1.3.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.33
            ExPASy - ENZYME nomenclature database: 3.6.1.33
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.33
            BRENDA, the Enzyme Database: 3.6.1.33
///
ENTRY       EC 3.6.1.34
NAME        H+-transporting ATP synthase
            H+-transporting ATPase
            Mitochondrial ATPase
            Coupling facotrs (F0-F1 and C0-F1)
            Chloroplast ATPase
            Bacterial Ca2+/Mg2+ ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (H+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    H+
COMMENT     A group of membrane-bound multi-subunit complexes in
            mitochondria, chloroplasts and bacteria in which ATP hydrolysis
            is coupled with transport of protons. In sealed vesicles the
            ATPase acticity is latent, unless a proton ionophore is available
            to discharge the proton gradient; these enzymes do not form a
            stable phosphoenzyme intermediate. Water-soluble subunit
            complexes (F1-CF1) can be extracted from these membrane-bound
            enzymes, which retain the ATPase activity but not the
            proton-transporting activity. Formerly included with EC 3.6.1.3.
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
            PATH: MAP00193  ATP Synthesis
            PATH: MAP00195  Photosynthesis
            PATH: MAP03070  Type III protein secretion system
            PATH: MAP03110  
GENES       ECO: b1941(fliI) b3731(atpC) b3732(atpD) b3733(atpG) b3734(atpA)
                 b3735(atpH) b3736(atpF) b3737(atpE) b3738(atpB)
            ECE: Z3031(fliI) Z4194 Z5119(escN) Z5229(atpC) Z5230(atpD)
                 Z5231(atpG) Z5232(atpA) Z5233(atpH) Z5234(atpF) Z5235(atpE)
                 Z5236(atpB)
            ECS: ECs2680 ECs3730 ECs4568 ECs4673 ECs4674 ECs4675 ECs4676
                 ECs4677 ECs4678 ECs4679 ECs4680
            YPE: YPO0267 YPO0717(fliI) YPO1827(fliI) YPO4120(atpC)
                 YPO4121(atpD) YPO4122(atpG) YPO4123(atpA) YPO4124(atpH)
                 YPO4125(atpF) YPO4126(atpE) YPO4127(atpB)
            HIN: HI0478(atpC) HI0479(atpD) HI0480(atpG) HI0481(atpA)
                 HI0482(atpH) HI0483(atpF) HI0484(atpE) HI0485(atpB)
            PMU: PM1488(atpB) PM1489(atpE) PM1490(atpF) PM1491(atpH)
                 PM1492(atpA) PM1493(atpG) PM1494(atpD) PM1495(atpC)
            XFA: XF1142 XF1143 XF1144 XF1145 XF1146 XF1147 XF1148 XF1149
            VCH: VC2130 VC2763 VC2764 VC2765 VC2766 VC2767 VC2768 VC2769
                 VC2770
            PAE: PA1104(fliI) PA1697 PA5553(atpC) PA5554(atpD) PA5555(atpG)
                 PA5556 PA5557(atpH) PA5558(atpF) PA5559(atpE) PA5560(atpB)
            BUC: BU002(atpB) BU003(atpE) BU004(atpF) BU005(atpH) BU006(atpA)
                 BU007(atpG) BU008(atpD) BU009(atpC) BU076(fliI)
            NME: NMB1933 NMB1934 NMB1935 NMB1936 NMB1937 NMB1938 NMB1939
                 NMB1940
            NMA: NMA0513(atpB) NMA0514(atpE) NMA0515(atpF) NMA0516(atpH)
                 NMA0517(atpA) NMA0518(atpG) NMA0519(atpD) NMA0520(atpC)
            HPY: HP0828(atpB) HP1131(atpC) HP1132(atpD) HP1133(atpG)
                 HP1134(atpA) HP1135(atpH) HP1136(atpF) HP1137(atpF')
                 HP1212(atpE) HP1420(fliI)
            HPJ: jhp0767 jhp1059 jhp1060 jhp1061 jhp1062 jhp1063 jhp1064
                 jhp1065 jhp1135 jhp1315
            CJE: Cj0102(atpF') Cj0103(atpF) Cj0104(atpH) Cj0105(atpA)
                 Cj0106(atpG) Cj0107(atpD) Cj0108(atpC) Cj0195(fliI)
                 Cj0936(atpE) Cj1204c(atpB)
            RPR: RP020(atpF) RP021(atpX) RP022(atpE) RP023(atpB) RP800(atpC)
                 RP801(atpD) RP802(atpG) RP803(atpA) RP804(atpH)
            RCO: RC0024(atpF) RC0026(atpE) RC0027(atpB) RC1234(atpC)
                 RC1235(atpD) RC1236(atpG) RC1237(atpA) RC1238(atpH)
            MLO: mll4059 mll4060 mll4063 mll4065 mll4066 mlr2909 mlr6342
                 mlr7411 mlr7413 mlr7415 msr7412
            SME: SMc00868(atpF) SMc00869(atpF2) SMc00870(atpE) SMc00871(atpB)
                 SMc02498(atpH) SMc02499(atpA) SMc02500(atpG) SMc02501(atpD)
                 SMc02502(atpC) SMc03025(fliI)
            ATU: AGR_C_1295 AGR_C_1297 AGR_C_1299 AGR_C_1301 AGR_C_4751
                 AGR_C_4754 AGR_C_4756 AGR_C_4757 AGR_C_4759 AGR_C_980
            CCR: CC0365 CC0366 CC0367 CC0368 CC3040 CC3445 CC3447 CC3448
                 CC3449 CC3450
            BSU: BG10243(fliI) BG10815(atpB) BG10816(atpE) BG10817(atpF)
                 BG10818(atpH) BG10819(atpA) BG10820(atpG) BG10821(atpD)
                 BG10822(atpC)
            BHA: BH2455(fliI) BH3753(atpC) BH3754(atpD) BH3755(atpG)
                 BH3756(atpA) BH3757(atpH) BH3758(atpF) BH3759(atpE)
                 BH3760(atpB)
            SAU: SA1904(atpC) SA1905(atpD) SA1906(atpG) SA1907(atpA)
                 SA1908(atpH) SA1909(atpF) SA1910(atpE) SA1911(atpB)
            SAV: SAV2089(atpC) SAV2090(atpD) SAV2091(atpG) SAV2092(atpA)
                 SAV2093(atpH) SAV2094(atpF) SAV2095(atpE) SAV2096(atpB)
            LLA: L10679(atpH) L11208(atpF) L11729(atpB) L5953(atpE)
                 L6563(atpD) L8105(atpG) L8990(atpA)
            SPY: SPy0148(ntpI) SPy0149(ntpK) SPy0150(ntpE) SPy0151(ntpC)
                 SPy0154(ntpA) SPy0155(ntpB) SPy0157(ntpD) SPy0754(atpE)
                 SPy0755(atpB) SPy0756(atpF) SPy0757(atpH) SPy0758(atpA)
                 SPy0759(atpG) SPy0760(atpD) SPy0761(atpC)
            SPN: SP1315 SP1316 SP1317 SP1318 SP1319 SP1320 SP1321 SP1322
                 SP1507 SP1508 SP1509 SP1510 SP1511 SP1512 SP1513 SP1514
            SPR: spr1359(atpC) spr1360(atpD) spr1361(atpG) spr1362(atpA)
                 spr1363(atpH) spr1364(atpF) spr1365(atpB) spr1366(atpE)
            CAC: CAC2159(fliL) CAC2864(atpC) CAC2865(atpD) CAC2866(atpG)
                 CAC2867(atpA) CAC2868(atpH) CAC2869(atpF) CAC2870(atpE)
                 CAC2871(atpB)
            MGE: MG398(atpC) MG399(atpD) MG400(atpG) MG401(atpA) MG402(atpH)
                 MG403(atpF) MG404(atpE) MG405(atpB)
            MPN: C12_orf293o(atpB) D02_orf105(atpE) D02_orf133a(atpC)
                 D02_orf178(atpH) D02_orf207(atpF) D02_orf279(atpG)
                 D02_orf475(atpD) D02_orf518(atpA)
            MPU: MYPU_2350(atpA) MYPU_2360(atpD) MYPU_2650(atpC)
                 MYPU_2660(atpD) MYPU_2670(atpG) MYPU_2680(atpA)
                 MYPU_2690(atpH) MYPU_2700(atpF) MYPU_2710(atpE)
                 MYPU_2720(atpB) MYPU_4490(atpA) MYPU_4500(atpD)
                 MYPU_6990(atpD) MYPU_7000(atpA)
            UUR: UU053(atpA-1) UU054(atpD-1) UU128(atpC) UU129(atpD-2)
                 UU130(atpG) UU132(atpA-2) UU133(atpH-1) UU134(atpH-2)
                 UU135(atpF) UU136(atpE) UU137(atpB)
            MTU: Rv1304(atpB) Rv1305(atpE) Rv1306(atpF) Rv1307(atpH)
                 Rv1308(atpA) Rv1309(atpG) Rv1310(atpD) Rv1311(atpC)
            MTC: MT1344 MT1345 MT1346 MT1347 MT1348 MT1349 MT1350 MT1351
            MLE: ML1139(atpB) ML1140(atpE) ML1141(atpF) ML1142(atpH)
                 ML1143(atpA) ML1144(atpG) ML1145(atpD) ML1146(atpC)
            CTR: CT304 CT305 CT306 CT307 CT308 CT310 CT669 CT717
            CMU: TC0040 TC0090 TC0578 TC0579 TC0580 TC0581 TC0582 TC0584
            CPN: CPn0086 CPn0088 CPn0089 CPn0090 CPn0091 CPn0092 CPn0707
                 CPn0858
            CPA: CP0039 CP0682 CP0683 CP0684 CP0685 CP0686 CP0688 CP1011
            CPJ: atpA atpB atpD atpE atpI atpK fliI yscN
            BBU: BB0090 BB0091 BB0092(atpD) BB0093(atpB) BB0094(atpA) BB0096
                 BB0288(fliI)
            TPA: TP0402 TP0424 TP0426 TP0427 TP0428 TP0429 TP0430 TP0527
                 TP0528 TP0529 TP0530 TP0531 TP0533
            SYN: sll1322(atpB) sll1323(atpG) sll1324(atpF) sll1325(atpH)
                 sll1326(atpA) sll1327(atpG) slr1329(atpD) slr1330(atpC)
                 ssl2615(atpE)
            DRA: DR0695 DR0696 DR0697 DR0698 DR0699 DR0700 DR0701 DR0702
            AAE: aq_1586(atpF1) aq_1587(atpF2) aq_1588(atpH) aq_1595(fliI)
                 aq_177(atpE) aq_179(atpB) aq_203(atpG2) aq_2038(atpD)
                 aq_2041(atpG1) aq_673(atpC) aq_679(atpA)
            TMA: TM0218 TM1609 TM1610 TM1611 TM1612 TM1613 TM1614 TM1615
                 TM1616
            MJA: MJ0216(atpB) MJ0217(atpA) MJ0218(atpF) MJ0219(atpC)
                 MJ0220(atpE) MJ0221 MJ0222 MJ0223 MJ0615(atpD)
            MTH: MTH953 MTH954 MTH955 MTH956 MTH957 MTH958 MTH959 MTH960
                 MTH961
            AFU: AF1158 AF1159(atpI) AF1160(atpK-1) AF1162(atpK-2)
                 AF1163(atpE) AF1164(atpC) AF1165(atpF) AF1166(atpA)
                 AF1167(atpB) AF1168(atpD)
            HAL: VNG2135G(atpD) VNG2138G(atpB) VNG2139G(atpA) VNG2140G(atpF)
                 VNG2141G(atpC) VNG2142G(atpE) VNG2143G(atpK) VNG2144G(atpI)
            TAC: Ta0001 Ta0002 Ta0003 Ta0004 Ta0005 Ta0006 Ta0008
            TVO: TVG0049983 TVG0050546 TVG0051618 TVG0051934 TVG0054274
                 TVG0055637 TVG0056269 TVG0058686
            PHO: PH1972 PH1974 PH1975 PH1976 PH1977 PH1978 PH1980 PH1981
                 PH1983
            PAB: PAB1179 PAB1180(atpI) PAB1181 PAB1182(atpE) PAB1183(atpC)
                 PAB1184(atpF) PAB1186(atpB) PAB2378(atpA) PAB2379(atpD)
            APE: APE0402 APE0404 APE0405 APE0410 APE0673 APE2326
            SSO: SSO0559(atpI) SSO0560(atpF) SSO0561(atpE) SSO0563(atpA)
                 SSO0564(atpB) SSO0566(atpD) SSO0567(atpK)
            SCE: Q0080(ATP8) Q0085(ATP6) Q0130(ATP9) YBL099W(ATP1)
                 YBR039W(ATP3) YBR127C(VMA2) YDL004W(ATP16) YDL185W(TFP1)
                 YDR298C(ATP5) YDR377W(ATP17) YEL027W(CUP5) YEL051W(VMA8)
                 YGR020C(VMA7) YHR026W(PPA1) YHR039C-A(VMA10) YJR121W(ATP2)
                 YKL016C(ATP7) YKL080W(VMA5) YLR295C(ATP14) YLR447C(VMA6)
                 YML081C-A(ATP18) YMR054W(STV1) YOL077W-A(ATP19) YOR270C(VPH1)
                 YOR332W(VMA4) YPL078C(ATP4) YPL234C(TFP3) YPL271W(ATP15)
                 YPR020W(ATP20) YPR036W(VMA13)
            SPO: ATP1(atp1) ATP2(atp2) ATP6(atp6) ATP8(atp8) ATP9(atp9)
                 SPAC11E3.07(spac11e3.07) SPAC16E8.07C(spac16e8.07c)
                 SPAC17A2.03C(spac17a2.03c) SPAC23C4.11(spac23c4.11)
                 SPAC2C4.13(spac2c4.13) SPAC732.01(spac732.01)
                 SPAC7D4.10(spac7d4.10) SPBC1289.05C(spbc1289.05c)
                 SPBC13E7.04(spbc13e7.04) SPBC1604.07(spbc1604.07)
                 SPBC1604.11(spbc1604.11) SPBC1734.13(spbc1734.13)
                 SPBC29A10.13(spbc29a10.13) SPBC31F10.15C(spbc31f10.15c)
                 SPBC3B9.18C(spbc3b9.18c) SPCC1840.06(spcc1840.06)
                 SPCC965.03(spcc965.03) VMA1(vma1) VMA2(vma2) VMA3(vma3)
            ATH: At1g12840(F13K23.9) At1g15700(F7H2.4) At1g19910(F6F9.3)
                 At1g20260(F14O10.13) At1g64070(F22C12.17) At1g64200(F22C12.4)
                 At1g75630(F10A5.17) At1g75980(T4O12.20) At1g76030(T4O12.24)
                 At1g78900(F9K20.5) At2g16510(F1P15.11) At2g21410(F3K23.17)
                 At2g25610(F3N11.6) At2g28520(T17D12.8) At2g33040(F25I18.22)
                 At3g01390(T13O15.3) At3g08560(F17O14.3) At3g28710(MZN14.4)
                 At3g28715(MZN14.21) At3g42050(F4M19.10) At3g52300(T25B15.70)
                 At3g58730(T20N10.80) At4g02620(T10P11.25) At4g04640(T19J18.4)
                 At4g09650(T25P22.90) At4g11150(T22B4.130) At4g23710(F9D16.180)
                 At4g25950(F20B18.60) At4g26710(F10M23.50) At4g32530(L23H3.10)
                 At4g34720(T4L20.300) At4g38510(F20M13.70) At4g38920(F19H22.20)
                 At4g39080(F19H22.180) At5g13450(T22N19.100)
                 At5g47030(MQD22.17) At5g55290(MCO15.24)
            CEL: C06H2.1 C34E10.6 C53B7.4 F02E8.1 F20B6.2 F27C1.7 F32D1.2
                 F35G12.10 F35H10.4 F46F11.5 F49C12.13 F52E1.10 F55H2.2
                 F58F12.1 H28O16.1 K07A12.3 R05D3.6 R53.4 T01H3.1 T14F9.1
                 VW02B12L.1 ZC262.5 ZK637.8b ZK970.4 vha-1 vha-2
            DME: CG1076 CG1088(Vha26) CG11154(ATPsyn-beta) CG11589
                 CG12403(Vha68) CG12602 CG1268 CG12810 CG13167 CG14909
                 CG1709(BcDNA:LD21248) CG17332(VhaSFD) CG17332_1(VhaSFD)
                 CG17369_1(Vha55) CG1746 CG18617 CG2934 CG2968 CG3161 CG3321
                 CG3612(blw) CG3762 CG4307(Oscp) CG4412(ATPsyn-Cf6) CG4624
                 CG4692 CG5075 CG5389 CG6030(ATPsyn-d) CG6105 CG6213(Vha13)
                 CG6737 CG7007 CG7026 CG7211 CG7547 CG7610(ATPsyn-gamma) CG7625
                 CG7678 CG7679 CG8048(Vha44) CG8048_2(Vha44) CG8186
                 CG8189(ATPsyn-b) CG8210(Vha14) CG9013 CG9032
            MMU: 106636(Atp5k) 107653(Atp5g1) 107777(Atp5j) 88116(Atpl)
                 894326(Atp6e)
            HSA: 10312(TCIRG1) 10476(ATP5JD) 10632(ATP5JG) 23545(TJ6)
                 4508(MTATP6) 4509(MTATP8) 498(ATP5A1) 499(ATP5A2) 506(ATP5B)
                 50617(ATP6N1B) 507(ATP5BL1) 508(ATP5BL2) 509(ATP5C1)
                 513(ATP5D) 51382(VATD) 514(ATP5E) 515(ATP5F1) 516(ATP5G1)
                 51606(LOC51606) 517(ATP5G2) 518(ATP5G3) 519(ATP5H) 521(ATP5I)
                 522(ATP5J) 523(ATP6A1) 524(ATP6A2) 525(ATP6B1) 526(ATP6B2)
                 527(ATP6L) 528(ATP6C) 529(ATP6E) 533(ATP6F) 535(ATP6N1A)
                 537(ATP6S1) 539(ATP5O) 8992(ATP6H) 9296(ATP6S14) 9550(ATP6J)
                 9551(ATP5J2)
DISEASE     MIM: 102910  ATP synthase, H+ transporting, mitochondrial F1
                         complex, beta
            MIM: 108729  ATP synthase, H+ transporting, mitochondrial F1
                         complex, gamma
            MIM: 108745  ATPase, H+ transporting, lysosomal, subunit C
            MIM: 108746  ATPase, H+ transporting, lysosomal (vacuolar proton
                         pump) 31kD
            MIM: 164360  ATP synthase, H+ transporting (ATPase, mitochondrial)
            MIM: 192132  ATPase, H+ transporting, lysosomal, beta polypeptide,
                         58kD (vacuolar
            MIM: 600828  ATP synthase, H+ transporting, mitochondrial F1
                         complex, O subunit
            MIM: 602736  ATP synthase, mitochondrial, C subunit-3
            MIM: 603152  ATP synthase, H+ transporting, mitochondrial F0
                         complex, subunit F6
            MIM: 603192  ATP synthase, H+ transporting, mitochondrial F0
                         complex, subunit C,
            MIM: 603193  ATP synthase, H+ transporting, mitochondrial F0
                         complex, subunit C,
MOTIF       PS: PS00152  P-[SAP]-[LIV]-[DNH]-x(3)-S-x-S
            PS: PS00153  [IV]-T-x-E-x(2)-[DE]-x(3)-G-A-x-[SAKR]
            PS: PS00389  [LIVM]-x-[LIVMFYT]-x(3)-[LIVMT]-[DENQK]-x(2)-[LIVM]-x-
                         [GSA]-G-[LIVMFYGA]-x-[LIVM]-[KRHENQ]-x-[GSEN]
            PS: PS00449  [STAGN]-x-[STAG]-[LIVMF]-R-L-x-[SAGV]-N-[LIVMT]
            PS: PS00605  [GSTA]-R-[NQ]-P-x(10)-[LIVMFYW](2)-x(3)-[LIVMFYW]-x-
                         [DE]
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
STRUCTURES  PDB: 1A91  1AQT  1ATY  1B9U  1BMF  1BSH  1ABV  1C0V  1C99  1COW  
                 1BSN  1DFA  1E16  1E1I  1E1Q  1E1R  1E79  1EF0  1EFR  1FS0  
                 1FX0  1H8E  1H8H  1D8S  1J7F  1MAB  1NBM  1QO1  1SKY  1VDE  
                 1HO8  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.34
            ExPASy - ENZYME nomenclature database: 3.6.1.34
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.34
            BRENDA, the Enzyme Database: 3.6.1.34
            SCOP (Structural Classification of Proteins): 3.6.1.34
///
ENTRY       EC 3.6.1.35
NAME        H+-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase(H+-transporting, acyl-phosphate-linked)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    H+
COMMENT     A gorup of enzymes from the plasma membranes of yeast and
            Neurospora. They are closely related to the H+/K+-transporting
            ATPases (EC 3.6.1.36), have a single catalytic sub-unit (100 kDa)
            and form phosphoenyzme intermediates. Formerly included with
            EC 3.6.1.3.
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
GENES       MJA: MJ1226(aha1)
            MTH: MTH481 MTH482
            TAC: Ta1045
            SCE: YGL008C(PMA1) YPL036W(PMA2)
            SPO: PMA1(pma1) PMA2(pma2)
            ATH: At1g17260(F20D23.4) At2g07560(F9A16.7) At2g18960(F19F24.16)
                 At2g24520(F25P17.18) At4g30190(F9N11.40)
MOTIF       PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.35
            ExPASy - ENZYME nomenclature database: 3.6.1.35
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.35
            BRENDA, the Enzyme Database: 3.6.1.35
///
ENTRY       EC 3.6.1.36
NAME        H+/K+-exchanging ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (H+/K+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    H+
            K+
COMMENT     So far characterized only in gastric mucosa. Hydrolysis of ATP
            is coupled with the exchange of H+ and K+ ions. The enzyme is
            functionally homologous with EC 3.6.1.35, 3.6.1.37 and 3.6.1.38,
            but not 3.6.1.34. Formerly included with EC 3.6.1.3.
            (EC 3.6.1.35 H+-transporting ATPase)
            (EC 3.6.1.37 Na+/K+-transporting ATPase)
            (EC 3.6.1.38 Ca2+-transporting ATPase)
PATHWAY     PATH: MAP00190  Oxidative phosphorylation
GENES       SME: SMb21578(atcU2)
            SPR: spr0641(ctpA) spr1410(pacL) spr1911(ctpC)
            SSO: SSO2896
            HSA: 495(ATP4A) 496(ATP4B)
DISEASE     MIM: 137216  ATPase, H+, K+ transporting, alpha
            MIM: 137217  ATPase, H+, K+ transporting, beta
            MIM: 182360  ATPase, Na+K+ transporting, alpha-1 polypeptide-like
            MIM: 277900  ATPase, Cu++ transporting, beta polypeptide
            MIM: 300011  ATPase, Cu++ transporting, alpha polypeptide
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
            PS: PS01047  [LIVNS]-x(2)-[LIVMFA]-x-C-x-[STAGCDNH]-C-x(3)-[LIVFG]-
                         x(3)-[LIV]-x(9,11)-[IVA]-x-[LVFYS]
STRUCTURES  PDB: 1FVQ  1FVS  2AW0  1AW0  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.36
            ExPASy - ENZYME nomenclature database: 3.6.1.36
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.36
            BRENDA, the Enzyme Database: 3.6.1.36
            SCOP (Structural Classification of Proteins): 3.6.1.36
///
ENTRY       EC 3.6.1.37
NAME        Na+/K+-exchanging ATPase
            Sodium pump
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (Na+/K+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    Na+
            K+
INHIBITOR   Ouabain
            GTP-gamma-S
COMMENT     An enzyme from the plasma membrane of animal cells. Hydrolysis
            of ATP is coupled with the exchange of Na+ and K+ ions, and
            is specifically inhibited by ouabain. Formerly included with
            EC 3.6.1.3.
            Also inhibited by GTP-gamma-S (D.L.McGill (1991) Biochemistry
            30, 6727-6734).
GENES       CEL: C01G12.8 C02E7.1 C09H5.2 C17E4.9 F55F3.3 eat-6
            DME: CG17923 CG3701 CG5670 CG5670_1 CG5670_2 CG5670_3 CG9258(Nrv1)
                 CG9261(Nrv2) CG9261_1(Nrv2)
            MMU: 88108(Atp1b1)
            HSA: 23439(ATP1B4) 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 479(ATP12A)
                 481(ATP1B1) 482(ATP1B2) 483(ATP1B3)
DISEASE     MIM: 182310  ATPase, Na+K+ transporting, alpha-1 polypeptide
            MIM: 182330  ATPase, Na+K+ transporting, beta-1 polypeptide
            MIM: 182331  ATPase, Na+K+ transporting, beta-2 polypeptide
            MIM: 182340  ATPase, Na+K+ transporting, alpha-2 polypeptide
            MIM: 182350  ATPase, Na+K+ transporting, alpha-3 polypeptide
            MIM: 601867  ATPase, Na+/K+ transporting, beta 3 polypeptide
MOTIF       PS: PS00152  P-[SAP]-[LIV]-[DNH]-x(3)-S-x-S
            PS: PS00153  [IV]-T-x-E-x(2)-[DE]-x(3)-G-A-x-[SAKR]
            PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
            PS: PS00389  [LIVM]-x-[LIVMFYT]-x(3)-[LIVMT]-[DENQK]-x(2)-[LIVM]-x-
                         [GSA]-G-[LIVMFYGA]-x-[LIVM]-[KRHENQ]-x-[GSEN]
            PS: PS00449  [STAGN]-x-[STAG]-[LIVMF]-R-L-x-[SAGV]-N-[LIVMT]
            PS: PS00605  [GSTA]-R-[NQ]-P-x(10)-[LIVMFYW](2)-x(3)-[LIVMFYW]-x-
                         [DE]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.37
            ExPASy - ENZYME nomenclature database: 3.6.1.37
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.37
            BRENDA, the Enzyme Database: 3.6.1.37
///
ENTRY       EC 3.6.1.38
NAME        Ca2+-transporting ATPase
            Calcium pump
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     ATP phosphohydrolase (Ca2+ -transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COFACTOR    Ca2+
            Vanadate
COMMENT     Hydrolysis of ATP is coupled with the transport of Ca2+ ions.
            The enzyme from the plasma membrane of eucaryotes differs from
            that found in sarcoplasmic reticulum in that it is activated by
            calmodulin, is sensitive to low concentrations of vanadate, and
            is of higher molecular mass (150 kDa). Formerly included with
            EC 3.6.1.3.
GENES       SCE: YAL026C(DRS2) YDR093W(YDR093W) YER166W YGL006W(PMC1)
                 YGL167C(PMR1) YIL048W(NEO1) YMR162C
            SPO: PGAK2(pgak2) SPAC24B11.12C(spac24b11.12c)
                 SPAC6C3.06C(spac6c3.06c)
            ATH: At1g10130(T27I1.16)
            CEL: F36H2.1 K11D9.2a K11D9.2b W09C2.3 W09D10.2 ZK256.1 ZK256.1a
                 ZK256.1b
            DME: CG11111(rdgB) CG2165 CG3725 CG3725_1 CG7651
            HSA: 489(ATP2A3) 490(ATP2B1) 491(ATP2B2) 492(ATP2B3) 493(ATP2B4)
DISEASE     MIM: 108731  ATPase, Ca++ transporting, plasma membrane, 1
            MIM: 108732  ATPase, Ca++ transporting, plasma membrane, 4
            MIM: 108740  ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2
MOTIF       PS: PS00154  D-K-T-G-T-[LIVM]-[TI]
STRUCTURES  PDB: 1CFF  1EUL  1FQU  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.38
            ExPASy - ENZYME nomenclature database: 3.6.1.38
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.38
            BRENDA, the Enzyme Database: 3.6.1.38
            SCOP (Structural Classification of Proteins): 3.6.1.38
///
ENTRY       EC 3.6.1.39
NAME        Thymidine-triphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     dTTP nucleotidohydrolase
REACTION    dTTP + H2O = dTDP + Orthophosphate
SUBSTRATE   dTTP
            H2O
PRODUCT     dTDP
            Orthophosphate
COMMENT     Also acts, more slowly, on dUTP and UTP.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.39
            ExPASy - ENZYME nomenclature database: 3.6.1.39
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.39
            BRENDA, the Enzyme Database: 3.6.1.39
///
ENTRY       EC 3.6.1.40
NAME        Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
            Guanosine pentaphosphate phosphohydrolase
            pppGpp 5'-phosphohydrolase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase
REACTION    Guanosine 3'-diphosphate 5'-triphosphate + H2O =
            Guanosine 3'-diphosphate 5'-diphosphate + Orthophosphate
SUBSTRATE   Guanosine 3'-diphosphate 5'-triphosphate
            H2O
PRODUCT     Guanosine 3'-diphosphate 5'-diphosphate
            Orthophosphate
COMMENT     Also hydrolyses other guanosine 5'-triphosphate deivatives with
            as least one unsubstituted phosphate group on the 3'-position, but
            not GTP, ATP or adenosine 5'-triphosphate,3'-diphosphate.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3779(gppA)
            ECE: Z5289(gppA)
            ECS: ECs4712
            YPE: YPO3870(gppA)
            VCH: VC0304
            HPY: HP0278(gppA)
            HPJ: jhp0263
            CJE: Cj0353c
            RCO: RC0392(gppA)
            AAE: aq_891(ppx)
            TMA: TM0195
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.40
            ExPASy - ENZYME nomenclature database: 3.6.1.40
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.40
            BRENDA, the Enzyme Database: 3.6.1.40
///
ENTRY       EC 3.6.1.41
NAME        Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
            Diadenosinetetraphosphatase (symmetrical)
            Dinucleosidetetraphosphate (symmetrical)
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     P1,P4-Bis(5'-nucleosyl)-tetraphosphate
            nucleotidebisphosphohydrolase
REACTION    P1,P4-Bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP
SUBSTRATE   P1,P4-Bis(5'-adenosyl) tetraphosphate
            H2O
            Bis(5'-guanosyl) tetraphosphate
            Bis(5'-adenosyl) pentaphosphate
PRODUCT     ADP
            GDP
COMMENT     Also acts on bis(5'-guanosyl) tetraphosphate and bis(5'-adenosyl)
            pentaphosphate, and, more slowly, on some other polyphosphates,
            forming a nucleoside bisphosphate as one product in all cases (cf.
            EC 3.6.1.17).
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0049(apaH)
            ECE: Z0058(apaH)
            ECS: ECs0054
            YPE: YPO0490(apaH)
            HIN: HI0551(apaH)
            PMU: PM1210(adaH)
            XFA: XF2150
            VCH: VC0441
            PAE: PA0590
            BUC: BU142(apaH)
            NMA: NMA0860(apaH)
            BSU: BG13145(yjbP)
            BHA: BH2845
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.41
            ExPASy - ENZYME nomenclature database: 3.6.1.41
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.41
            BRENDA, the Enzyme Database: 3.6.1.41
///
ENTRY       EC 3.6.1.42
NAME        Guanosine-diphosphatase
            GDPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GDP phosphohydrolase
REACTION    GDP + H2O = GMP + Orthophosphate
SUBSTRATE   GDP
            H2O
            UDP
PRODUCT     GMP
            Orthophosphate
            UMP
COMMENT     Also acts on UDP but not on other nucleoside diphosphates and
            triphosphate.
GENES       SCE: YEL042W(GDA1)
MOTIF       PS: PS01238  [LIVM]-x-G-x(2)-E-G-x-[FY]-x-[FW]-[LIVA]-[TAG]-x-N-[HY]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.42
            ExPASy - ENZYME nomenclature database: 3.6.1.42
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.42
            BRENDA, the Enzyme Database: 3.6.1.42
///
ENTRY       EC 3.6.1.43
NAME        Dolichyldiphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Dolichyl-diphosphate phosphohydrolase
REACTION    Dolichyl diphosphate + H2O = Dolichyl phosphate + Orthophosphate
SUBSTRATE   Dolichyl diphosphate
            H2O
PRODUCT     Dolichyl phosphate
            Orthophosphate
PATHWAY     PATH: MAP00510  Glycoprotein biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.43
            ExPASy - ENZYME nomenclature database: 3.6.1.43
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.43
            BRENDA, the Enzyme Database: 3.6.1.43
///
ENTRY       EC 3.6.1.44
NAME        Oligosaccharide-diphosphodolichol pyrophosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     Oligosaccharide-diphosphodolichol phosphodolichohydrolase
REACTION    Oligosaccharide-diphosphodolichol + H2O =
            Oligosaccharide phosphate + Dolichyl phosphate
SUBSTRATE   Oligosaccharide-diphosphodolichol
            H2O
PRODUCT     Oligosaccharide phosphate
            Dolichyl phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.44
            ExPASy - ENZYME nomenclature database: 3.6.1.44
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.44
            BRENDA, the Enzyme Database: 3.6.1.44
///
ENTRY       EC 3.6.1.45
NAME        UDP-sugar diphosphatase
            UDP-sugar pyrophosphatase
            Nucleosidediphosphate-sugar pyrophosphatase
            UDP-sugar hydrolase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
REACTION    UDP-sugar + H2O = UMP + Sugar 1-phosphate
SUBSTRATE   UDP-sugar
            H2O
PRODUCT     UMP
            Sugar 1-phosphate
COMMENT     UDP-sugar is the best substrate,although other nucleoside-
            sugar diphosphates are used as substrates with similar KM
            values but much lower maximum velocities. Thus this enzyme
            has a distinct specificity from ADP-sugar pyrophosphatase
            (EC 3.6.1.21).
            Some but not all enzymes of this class also appear to have
            5'-Nucleotidase (EC 3.1.3.5) activity.
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b0480(ushA)
            ECE: Z0599(ushA)
            ECS: ECs0533
            YPE: YPO3090(ushA)
            PMU: PM1193
            VCH: VC2174
            TMA: TM1878
MOTIF       PS: PS00785  [LIVM]-x-[LIVM](2)-[HEA]-[TI]-x-D-x-H-[GSA]-x-[LIVMF]
            PS: PS00786  [FYP]-x(4)-[LIVM]-G-N-H-E-F-[DN]
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.45
            ExPASy - ENZYME nomenclature database: 3.6.1.45
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.45
///
ENTRY       EC 3.6.1.46
NAME        Heterotrimeric G-protein GTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (signalling)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     This group comprises GTP-hydrolysing systems, where GTP and GDP
            alternate in binding. This group includes stimulatory and
            imhibitory G-proteins such as Gs, Gi, Go and Golf, targetting
            adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating
            phospholipase C; transducin activating cGMP phosphodiesterase;
            gustducin activating cAMP phosphodiesterase. Golf is instrumental
            in odour perception, transducin in vision and gustducin in taste
            recognition. At least 16 different alpha subunits (39-52 kDa), 5
            beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.46
            ExPASy - ENZYME nomenclature database: 3.6.1.46
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.46
///
ENTRY       EC 3.6.1.47
NAME        Small monomeric GTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (cell-regulating)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     A family of about 50 enzymes with a molecular mass of 21 kDa that
            are distantly related to the alpha-subunit of heterotrimeric 
            G-protein GTPase (EC 3.6.1.46). They are involved in cell-growth 
            regulation (Ras subfamily), membrane vesicle traffic and uncoating
            (Rab and ARF subfamilies), nuclear protein import (Ran subfamily)
            and organization of the cytoskeleton (Rho and Rac subfamilies).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.47
            ExPASy - ENZYME nomenclature database: 3.6.1.47
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.47
///
ENTRY       EC 3.6.1.48
NAME        Protein-synthesizing GTPase
            Initiation factor (IF)
            Elongation factor (EF)
            Peptide-release or termination factor
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (mRNA-translation-assisting)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     This enzyme comprises a family of proteins involved in prokaryotic
            as well as eukaryotic protein synthesis. In the initiation factor
            complex, it is IF-2b (98 kDa) that binds GTP and subsequently
            hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa)
            that binds GTP. In the elongation phase, the GTP-hydrolysing
            proteins are the EF-Tu polypeptide of the prokaryotic transfer
            factor (43 kDa), the eukaryotic elongation factor EF-1alpha
            (53 kDa),the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 
            (70-110 kDa) and the signal recognition particle that play a role 
            in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and 
            EF1alpha catalyse binding of aminoacyl-tRNA to the ribosomal 
            A-site, while EF-G and EF-2 catalyse the translocation of 
            peptidyl-tRNA from the A-site to the P-site. GTPase activity is 
            also involved in polypeptide release from the ribosome with the 
            aid of the pRFs and eRFs.
GENES       ECO: b3339(tufA) b3340(fusA) b3980(tufB)
            ECE: Z4697(tufA) Z4698(fusA) Z5553(tufB)
            ECS: ECs4190 ECs4191 ECs4903
            YPE: YPO0202(fusA) YPO0203(tufA)
            HIN: HI0578(tufB) HI0579(1fusA) HI0632(tufB)
            PMU: PM1356(fusA) PM1357(tufA) PM1746(tufB)
            XFA: XF2628 XF2629 XF2640
            VCH: VC0321 VC0361 VC0362 VC2342
            PAE: PA2071(fusA2) PA4265(tufA) PA4266(fusA1) PA4277(tufB)
            BUC: BU526(tufB) BU527(fusA)
            NME: NMB0124 NMB0138 NMB0139
            NMA: NMA0134(tufA1) NMA0135(fusA) NMA0149(tufA2)
            HPY: HP1195(fusA) HP1205(tuf)
            HPJ: jhp1118 jhp1128
            CJE: Cj0470(tuf) Cj0493(fusA)
            RPR: RP132(fusA) RP661(tuf)
            RCO: RC0174(fusA) RC1008(tuf)
            MLO: mlr0263 mlr0286 mlr0288 mlr2549
            SME: SMb20049(fusA2) SMc01311(tufA) SMc01312(fusA1) SMc01326(tufB)
            ATU: AGR_C_3557 AGR_C_3558 AGR_C_3583
            CCR: CC1240 CC3199 CC3200
            BSU: BG11056(tufA) BG11939(fus)
            BHA: BH0131(fus) BH0132(tufA)
            SAU: SA0505(fus) SA0506(tufA)
            SAV: SAV0536(fus) SAV0537(eftu)
            LLA: L0368(fusA) L0371(tuf)
            SPY: SPy0273(fus) SPy0611(tufA)
            SPN: SP0273 SP1489
            SPR: spr0250(fusA) spr1343(tufA)
            CAC: CAC1448(tetP/tetQ) CAC3136(tufA) CAC3138(fus)
            MGE: MG089(fusA) MG451(tuf)
            MPN: G07_orf688(fusA) K05_orf394(tuf)
            MPU: MYPU_4050(tufA) MYPU_4280(fus)
            UUR: UU522(tuf) UU523(fusA)
            MTU: Rv0120c(fusA2) Rv0684(fusA) Rv0685(tuf)
            MTC: MT0128 MT0712 MT0713
            MLE: ML1877(tuf) ML1878(fusA)
            CTR: CT322(tuf) CT437(fus)
            CMU: TC0596 TC0721
            CPN: CPn0074 CPn0550
            CPA: CP0202 CP0701
            CPJ: fusA tufA
            BBU: BB0476(tuf) BB0540(fus-1) BB0691(fus-2)
            TPA: TP0187(tuf) TP0450(fusA-1) TP0767(fusA-2)
            SYN: sll0830(fus) sll1098(fusB) sll1099(tufA) slr1463(fusA)
            DRA: DR0307 DR0309 DR0393 DR2050
            AAE: aq_001(fusA) aq_005(tufA1) aq_1928(tufA2)
            TMA: TM1502 TM1503 TM1651
            MJA: MJ0324(tuf) MJ0495 MJ1048(fus)
            MTH: MTH1057 MTH1058 MTH1185
            AFU: AF0937(tuf) AF1894(fus)
            HAL: VNG2649G(eef1a) VNG2654G(eef2)
            TAC: Ta0444 Ta0446
            TVO: TVG1104527 TVG1107082
            PHO: PH1484 PH1899
            PAB: PAB0187(fus) PAB0465(tuf)
            APE: APE1432 APE1844
            SSO: SSO0216(tuF-1) SSO0728(EF-2) SSO2429(tuF-2)
            STO: ST0269 ST0437 ST0557
            SCE: YBR118W(TEF2) YDR385W(EFT2) YJL102W(MEF2) YKR084C(HBS1)
                 YLR069C(MEF1) YOR133W(EFT1) YOR187W(TUF1) YPR080W(TEF1)
            SPO: EF1-B_1(ef1-b) EF1-B_2(ef1-b) EFT1(eft1) EFT2(eft2)
                 SPBC215.12(spbc215.12) SPBC409.22C SPBC660.10(spbc660.10)
                 SPBC9B6.04C(spbc9b6.04c) SPCC553.08C(spcc553.08c)
                 TEF1-E(tef1-e)
            ATH: At4g20360(F9F13.10)
            CEL: C43E11.4 F29C12.4 K07A12.4 K10C3.5 R03G5.1 eft-1 eft-2 eft-3
            DME: CG12736 CG1873(Ef1alpha100E) CG2238(Ef2b) CG4567 CG4638
                 CG4849 CG6050 CG6943 CG8280(Ef1alpha48D)
            HSA: 1915(EEF1A1) 1917(EEF1A2) 1938(EEF2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.48
            ExPASy - ENZYME nomenclature database: 3.6.1.48
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.48
///
ENTRY       EC 3.6.1.49
NAME        Signal-recognition-particle GTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (protein-synthesis-assisting)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     Activity is associated with the signal-recognition particle (a
            protein- and RNA-containing structure involved in endoplasmic-
            reticulum-associated protein synthesis).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.49
            ExPASy - ENZYME nomenclature database: 3.6.1.49
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.49
///
ENTRY       EC 3.6.1.50
NAME        Dynamin GTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (vesicle-releasing)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     An enzyme with a molecular mass of about 100 kDa that is involved
            in endocytosis and is instrumental in pinching off membrane
            vesicles.
GENES       DME: CG18102
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.50
            ExPASy - ENZYME nomenclature database: 3.6.1.50
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.50
///
ENTRY       EC 3.6.1.51
NAME        Tubulin GTPase
CLASS       Hydrolases
            Acting on acid anhydrides
            In phosphorus-containing anhydrides
SYSNAME     GTP phosphohydrolase (microtubule-releasing)
REACTION    GTP + H2O = GDP + Orthophosphate
SUBSTRATE   GTP
            H2O
PRODUCT     GDP
            Orthophosphate
COMMENT     An intrinsic activity of alpha-tubulin involved in tubulin folding,
            division plane formation in prokaryotic cells and others.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.1.51
            ExPASy - ENZYME nomenclature database: 3.6.1.51
            WIT (What Is There) Metabolic Reconstruction: 3.6.1.51
///
ENTRY       EC 3.6.2.1
NAME        Adenylylsulfatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In sulfonyl-containing anhydrides
SYSNAME     Adenylylsulfate sulfohydrolase
REACTION    Adenylylsulfate + H2O = AMP + Sulfate
SUBSTRATE   Adenylylsulfate
            H2O
PRODUCT     AMP
            Sulfate
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.2.1
            ExPASy - ENZYME nomenclature database: 3.6.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.6.2.1
            BRENDA, the Enzyme Database: 3.6.2.1
///
ENTRY       EC 3.6.2.2
NAME        Phosphoadenylylsulfatase
CLASS       Hydrolases
            Acting on acid anhydrides
            In sulfonyl-containing anhydrides
SYSNAME     3'-Phosphoadenylylsulfate sulfohydrolase
REACTION    3'-Phosphoadenylylsulfate + H2O = Adenosine 3',5'-bisphosphate +
            Sulfate
SUBSTRATE   3'-Phosphoadenylylsulfate
            H2O
PRODUCT     Adenosine 3',5'-bisphosphate
            Sulfate
COFACTOR    Manganese
COMMENT     Requires Mn2+.
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.2.2
            ExPASy - ENZYME nomenclature database: 3.6.2.2
            WIT (What Is There) Metabolic Reconstruction: 3.6.2.2
            BRENDA, the Enzyme Database: 3.6.2.2
///
ENTRY       EC 3.6.3.1
NAME        Mg2+-ATPase
            Flippase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (phospholipid-flipping)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. The enzyme apparently has several activities, one
            of them being the movement of phospholipids from one membrane face
            to the other ('flippase').
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.1
            ExPASy - ENZYME nomenclature database: 3.6.3.1
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.1
///
ENTRY       EC 3.6.3.2
NAME        Mg2+-importing ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Mg2+-importing)
REACTION    ATP + H2O + Mg2+(out) = ADP + Orthophosphate + Mg2+(in)
SUBSTRATE   ATP
            H2O
            Mg2+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This enzyme occurs in both Gram-positive and Gram-
            negative bacteria, and three types are known, designated as CorA,
            MgtA and MgtB. The major enzyme is CorA, which also transports Co2+
            and Ni2+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.2
            ExPASy - ENZYME nomenclature database: 3.6.3.2
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.2
///
ENTRY       EC 3.6.3.3
NAME        Cd2+-exporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Cd2+-exporting)
REACTION    ATP + H2O + Cd2+(in) = ADP + Orthophosphate + Cd2+(out)
SUBSTRATE   ATP
            H2O
            Cd2+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This enzyme occurs in protozoa, fungi and plants.
GENES       ECO: b3469(zntA)
            ECE: Z4843(zntA)
            ECS: ECs4318
            HPY: HP0791(cadA)
            HPJ: jhp0727
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.3
            ExPASy - ENZYME nomenclature database: 3.6.3.3
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.3
///
ENTRY       EC 3.6.3.4
NAME        Cu2+-exporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Cu2+-exporting)
REACTION    ATP + H2O + Cu2+(in) = ADP + Orthophosphate + Cu2+(out)
SUBSTRATE   ATP
            H2O
            Cu2+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This bacterial and mammalian enzyme exports Cu2+
            from cells. In humans, it is involved in Menkes disease and
            Wilson's disease.
GENES       ECO: b0484(ybaR)
            ECE: Z0604(ybaR)
            ECS: ECs0537
            HPY: HP1072(copA)
            HPJ: jhp0353
            SME: SMa1013(actP)
            BSU: BG14106(yvgX)
            BHA: BH0557
            SPY: SPy1715(copA)
            CAC: CAC3655
            UUR: UU203(copA)
            MJA: MJ0968(copA)
            AFU: AF0152(copB)
            SCE: YBR295W(PCA1) YDR270W(CCC2)
            CEL: Y76A2A.2
            MMU: 99400(Atp7a)
            HSA: 538(ATP7A) 540(ATP7B)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.4
            ExPASy - ENZYME nomenclature database: 3.6.3.4
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.4
///
ENTRY       EC 3.6.3.5
NAME        Zn2+-exporting ATPase
            Zn(II)-translocating P-type ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Zn2+-exporting)
REACTION    ATP + H2O + Zn2+(in) = ADP + Orthophosphate + Zn2+(out)
SUBSTRATE   ATP
            H2O
            Zn2+
            Cd2+
            Pb2+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This bacterial and animal enzyme also exports Cd2+
            and Pb2+.
GENES       ECO: b3469(zntA)
            ECE: Z4843(zntA)
            ECS: ECs4318
            HPY: HP0791(cadA)
            HPJ: jhp0727
            SYN: slr0798(ziaA)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.5
            ExPASy - ENZYME nomenclature database: 3.6.3.5
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.5
///
ENTRY       EC 3.6.3.6
NAME        H+-exporting ATPase
            Proton-translocating ATPase
            Yeast plasma membrane H+-ATPase
            Yeast plasma membrane ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (H+-exporting)
REACTION    ATP + H2O + H+(in) = ADP + Orthophosphate + H+(out)
SUBSTRATE   ATP
            H2O
            H+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This enzyme occurs in protozoa, fungi and plants,
            and generates an electrochemical potential gradient of protons
            across the plasma membrane.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.6
            ExPASy - ENZYME nomenclature database: 3.6.3.6
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.6
///
ENTRY       EC 3.6.3.7
NAME        Na+-exporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Na+-exporting)
REACTION    ATP + H2O + Na+(in) = ADP + Orthophosphate + Na+(out)
SUBSTRATE   ATP
            H2O
            Na+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This enzyme, which is found in Gram-positive
            bacteria and in yeast, is involved in the efflux of Na+, with one
            ion being exported per ATP hydrolysed.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.7
            ExPASy - ENZYME nomenclature database: 3.6.3.7
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.7
///
ENTRY       EC 3.6.3.8
NAME        Ca2+-transporting ATPase
            Sarcoplasmic reticulum ATPase
            Sarco(endo)plasmic reticulum Ca2+-ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Ca2+-transporting)
REACTION    ATP + H2O + Ca2+(cis) = ADP + Orthophosphate + Ca2+(trans)
SUBSTRATE   ATP
            H2O
            Ca2+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This enzyme family comprises three types of Ca2+-
            transporting enzymes that are found in the plasma membrane, the
            sarcoplasmic reticulum and in yeast. The first and third transport
            one ion per ATP hydrolysed, whereas the second transports two ions.
GENES       HSA: 27032(ATP2C1) 487(ATP2A1) 488(ATP2A2)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.8
            ExPASy - ENZYME nomenclature database: 3.6.3.8
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.8
///
ENTRY       EC 3.6.3.9
NAME        Na+/K+-exchanging ATPase
            Sodium pump
            Na+,K+ pump
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Na+/K+-exchanging)
REACTION    ATP + H2O + Na+(in) + K+(out) = ADP + Orthophosphate + Na+(out) +
            K+(in)
SUBSTRATE   ATP
            H2O
            Na+
            K+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. This is a plasma membrane enzyme, ubiquitous in
            animal cells, that catalyses the efflux of three Na+ and influx of
            two K+ per ATP hydrolysed. It is apparently involved in generating
            the plasma membrane electrical potential.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.9
            ExPASy - ENZYME nomenclature database: 3.6.3.9
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.9
///
ENTRY       EC 3.6.3.10
NAME        H+/K+-exchanging ATPase
            H+-K+-ATPase
            H,K-ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (H+/K+-exchanging)
REACTION    ATP + H2O + H+(in) + K+(out) = ADP + Orthophosphate + H+(out) +
            K+(in)
SUBSTRATE   ATP
            H2O
            H+
            K+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. A gastric mucosal enzyme that catalyses the efflux
            of one H+ and the influx of one K+ per ATP hydrolysed.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.10
            ExPASy - ENZYME nomenclature database: 3.6.3.10
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.10
///
ENTRY       EC 3.6.3.11
NAME        Cl--transporting ATPase
            Cl--translocating ATPase
            Cl--motive ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Cl--importing)
REACTION    ATP + H2O + Cl-(out) = ADP + Orthophosphate + Cl-(in)
SUBSTRATE   ATP
            H2O
            Cl-
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. An animal and plant enzyme involved in the import
            of chloride anions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.11
            ExPASy - ENZYME nomenclature database: 3.6.3.11
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.11
///
ENTRY       EC 3.6.3.12
NAME        K+-transporting ATPase
            K+-translocating Kdp-ATPase
            Multi-subunit K+-transport ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (K+-importing)
REACTION    ATP + H2O + K+(out) = ADP + Orthophosphate + K+(in)
SUBSTRATE   ATP
            H2O
            K+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. A bacterial enzyme of di(heterotetrameric)
            structure that is involved in K+ import. The probable stoichiometry
            is one ion per ATP hydrolysed.
GENES       ECO: b0696(kdpC) b0697(kdpB) b0698(kdpA)
            ECE: Z0843(kdpC) Z0844(kdpB) Z0845(kdpA)
            ECS: ECs0724 ECs0725 ECs0726
            PAE: PA1633 PA1634(kdpB) PA1635(kdpC)
            CJE: Cj0676(kdpA) Cj0677(kdpB) Cj0678(kdpC)
            MLO: mll3129 mll3130 mll3133
            CCR: CC1591 CC1592 CC1593
            SAU: SA0068(kdpA(SCCmec)) SA0069 SA0070(kdpB(SCCmec))
                 SA0071(kdpC(SCCmec)) SA1879(kdpC) SA1880(kdpB) SA1881(kdpA)
            SAV: SAV0066(kdpA) SAV0067(kdpB) SAV0068 SAV2060(kdpC)
                 SAV2061(kdpB) SAV2062(kdpA)
            CAC: CAC3680(kdpC/atkC) CAC3681(kdpB/atkB) CAC3682(kdpA/atkA)
            MTU: Rv1029(kdpA) Rv1030(kdpB) Rv1031(kdpC)
            MTC: MT1058 MT1059 MT1060
            SYN: slr1728(kdpA) slr1729(kdpB) slr1730(kdpC)
            DRA: DRB0083 DRB0086 DRB0087
            HAL: VNG6176G(kdpA) VNG6177G(kdpB) VNG6178G(kdpC)
            TAC: Ta1308 Ta1309 Ta1310
            TVO: TVG0487282 TVG0489285 TVG0489908
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.12
            ExPASy - ENZYME nomenclature database: 3.6.3.12
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.12
///
ENTRY       EC 3.6.3.13
NAME        Aminophospholipid-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (aminophospholipid-transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that undergoes covalent phosphorylation during the
            transport cycle. An animal enzyme that is involved in the export of
            (amino)phospholipids and resembles a 'flippase' (see EC 3.6.3.1) in
            function.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.13
            ExPASy - ENZYME nomenclature database: 3.6.3.13
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.13
///
ENTRY       EC 3.6.3.14
NAME        H+-transporting two-sector ATPase
            ATP synthase
            F1-ATPase
            FoF1-ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (H+-transporting)
REACTION    ATP + H2O + H+(in) = ADP + Orthophosphate + H+(out)
SUBSTRATE   ATP
            H2O
            H+
PRODUCT     ADP
            Orthophosphate
COMMENT     A multisubunit non-phosphorylated ATPase that is involved in the
            transport of ions. Large enzymes of mitochondria, chloroplasts and
            bacteria with a membrane sector (Fo, Vo, Ao) and a cytoplasmic-
            compartment sector (F1, V1, A1). The F-type enzymes of the inner
            mitochondrial and thylakoid membranes act as ATP synthases. All of
            the enzymes included here operate in a rotational mode, where the
            extramembrane sector (containing 3 alpha- and 3 beta-subunits) is
            connected via the delta-subunit to the membrane sector by several
            smaller subunits. Within this complex, the gamma- and epsilon-
            subunits, as well as the 9-12 c subunits rotate by consecutive    
            120; angles and perform parts of ATP synthesis. This movement is
            driven by the H+ electrochemical potential gradient. The V-type
            (in vacuoles and clathrin-coated vesicles) and A-type
            (archebacterial) enzymes have a similar structure but, under 
            physiological conditions, they pump H+ rather than synthesize ATP.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.14
            ExPASy - ENZYME nomenclature database: 3.6.3.14
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.14
///
ENTRY       EC 3.6.3.15
NAME        Na+-transporting two-sector ATPase
            ATP synthase
            Vacuolar-type Na+-ATPase
            Na+-translocating ATPase
            Na+-translocating F1Fo-ATPase
            Vacuolar-type Na+-translocating ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Na+-transporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
            Na+
PRODUCT     ADP
            Orthophosphate
COMMENT     A multisubunit non-phosphorylated ATPase that is involved in the
            transport of ions. An enzyme found in alkaliphilic bacteria that is
            similar to EC 3.6.3.14 (H+-transporting two-sector ATPase) where
            Na+ replaces H+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.15
            ExPASy - ENZYME nomenclature database: 3.6.3.15
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.15
///
ENTRY       EC 3.6.3.16
NAME        Arsenite-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (arsenite-exporting)
REACTION    ATP + H2O + Arsenite(in) = ADP + Orthophosphate + Arsenite(out)
SUBSTRATE   ATP
            H2O
            Arsenite
PRODUCT     ADP
            Orthophosphate
COMMENT     A multisubunit non-phosphorylated ATPase that is involved in the
            transport of ions. A bacterial enzyme that usually contains two
            subunits where one (with 12 membrane-spanning segments) forms the
            'channel' part and the other (occurring in pairs peripherally to
            the membrane) contains the ATP-binding site. Exports arsenite and
            antimonite anions.
STRUCTURES  PDB: 1II9  1IHU  1II0  
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.16
            ExPASy - ENZYME nomenclature database: 3.6.3.16
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.16
///
ENTRY       EC 3.6.3.17
NAME        Monosaccharide-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (monosaccharide-importing)
REACTION    ATP + H2O + Monosaccharide(out) = ADP + Orthophosphate +
            Monosaccharide(in)
SUBSTRATE   ATP
            H2O
            Monosaccharide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Family of bacterial
            enzymes importing ribose, xylose, arabinose, galactose and
            methylgalactoside.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.17
            ExPASy - ENZYME nomenclature database: 3.6.3.17
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.17
///
ENTRY       EC 3.6.3.18
NAME        Oligosaccharide-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (disaccharide-importing)
REACTION    ATP + H2O + Oligosaccharide(out) = ADP + Orthophosphate +
            Oligosaccharide(in)
SUBSTRATE   ATP
            H2O
            Oligosaccharide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports lactose, melibiose and raffinose.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.18
            ExPASy - ENZYME nomenclature database: 3.6.3.18
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.18
///
ENTRY       EC 3.6.3.19
NAME        Maltose-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (maltose-importing)
REACTION    ATP + H2O + Maltose(out) = ADP + Orthophosphate + Maltose(in)
SUBSTRATE   ATP
            H2O
            Maltose
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Comprises bacterial
            enzymes that import maltose and maltose oligosaccharides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.19
            ExPASy - ENZYME nomenclature database: 3.6.3.19
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.19
///
ENTRY       EC 3.6.3.20
NAME        Glycerol-3-phosphate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (glycerol-3-phosphate-importing)
REACTION    ATP + H2O + Glycerol-3-phosphate(out) = ADP + Orthophosphate +
            Glycerol-3-phosphate(in)
SUBSTRATE   ATP
            H2O
            Glycerol-3-phosphate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports phosphorylated glycerol.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.20
            ExPASy - ENZYME nomenclature database: 3.6.3.20
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.20
///
ENTRY       EC 3.6.3.21
NAME        Polar-amino-acid-transporting ATPase
            Histidine permease
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (polar-amino-acid-importing)
REACTION    ATP + H2O + Polar amino acid(out) = ADP + Orthophosphate + Polar
            amino acid(in)
SUBSTRATE   ATP
            H2O
            Polar amino acid
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Comprises bacterial
            enzymes that import His, Arg, Lys, Glu, Gln, Asp, ornithine,
            octopine and nopaline.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.21
            ExPASy - ENZYME nomenclature database: 3.6.3.21
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.21
///
ENTRY       EC 3.6.3.22
NAME        Nonpolar-amino-acid-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (nonpolar-amino-acid-transporting)
REACTION    ATP + H2O + Nonpolar amino acid(out) = ADP + Orthophosphate +
            Nonpolar amino acid(in)
SUBSTRATE   ATP
            H2O
            Nonpolar amino acid
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Comprises bacterial
            enzymes that import Leu, Ile and Val.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.22
            ExPASy - ENZYME nomenclature database: 3.6.3.22
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.22
///
ENTRY       EC 3.6.3.23
NAME        Oligopeptide-transporting ATPase
            Oligopeptide permease
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (oligopeptide-importing)
REACTION    ATP + H2O + Oligopeptide(out) = ADP + Orthophosphate +
            Oligopeptide(in)
SUBSTRATE   ATP
            H2O
            Oligopeptide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports di- and oligopeptides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.23
            ExPASy - ENZYME nomenclature database: 3.6.3.23
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.23
///
ENTRY       EC 3.6.3.24
NAME        Nickel-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (nickel-importing)
REACTION    ATP + H2O + Ni2+(out) = ADP + Orthophosphate + Ni2+(in)
SUBSTRATE   ATP
            H2O
            Ni2+
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports Ni2+.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.24
            ExPASy - ENZYME nomenclature database: 3.6.3.24
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.24
///
ENTRY       EC 3.6.3.25
NAME        Sulfate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (sulfate-importing)
REACTION    ATP + H2O + Sulfate(out) = ADP + Orthophosphate + Sulfate(in)
SUBSTRATE   ATP
            H2O
            Sulfate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports sulfate and thiosulfate anions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.25
            ExPASy - ENZYME nomenclature database: 3.6.3.25
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.25
///
ENTRY       EC 3.6.3.26
NAME        Nitrate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (nitrate-importing)
REACTION    ATP + H2O + Nitrate(out) = ADP + Orthophosphate + Nitrate(in)
SUBSTRATE   ATP
            H2O
            Nitrate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports NO3-, NO2- and OCN-.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.26
            ExPASy - ENZYME nomenclature database: 3.6.3.26
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.26
///
ENTRY       EC 3.6.3.27
NAME        Phosphate-transporting ATPase
            ABC phosphate transporter
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (phosphate-importing)
REACTION    ATP + H2O + Phosphate(out) = ADP + Orthophosphate + Phosphate(in)
SUBSTRATE   ATP
            H2O
            Phosphate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports phosphate anions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.27
            ExPASy - ENZYME nomenclature database: 3.6.3.27
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.27
///
ENTRY       EC 3.6.3.28
NAME        Phosphonate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (phosphonate-transporting)
REACTION    ATP + H2O + Phosphonate(out) = ADP + Orthophosphate
            + Phosphonate(in)
SUBSTRATE   ATP
            H2O
            Phosphonate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports phosphonate and organophosphate anions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.28
            ExPASy - ENZYME nomenclature database: 3.6.3.28
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.28
///
ENTRY       EC 3.6.3.29
NAME        Molybdate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (molybdate-importing)
REACTION    ATP + H2O + Molybdate(out) = ADP + Orthophosphate + Molybdate(in)
SUBSTRATE   ATP
            H2O
            Molybdate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports molybdate anions.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.29
            ExPASy - ENZYME nomenclature database: 3.6.3.29
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.29
///
ENTRY       EC 3.6.3.30
NAME        Fe3+-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (ferric-ion-transporting)
REACTION    ATP + H2O + Fe3+(out) = ADP + Orthophosphate + Fe3+(in)
SUBSTRATE   ATP
            H2O
            Fe3+
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports ferric cations.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.30
            ExPASy - ENZYME nomenclature database: 3.6.3.30
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.30
///
ENTRY       EC 3.6.3.31
NAME        Polyamine-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (polyamine-importing)
REACTION    ATP + H2O + Polyamine(out) = ADP + Orthophosphate + Polyamine(in)
SUBSTRATE   ATP
            H2O
            Polyamine
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports putrescine and spermidine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.31
            ExPASy - ENZYME nomenclature database: 3.6.3.31
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.31
///
ENTRY       EC 3.6.3.32
NAME        Quaternary-amine-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (quaternary-amine-importing)
REACTION    ATP + H2O + Quaternary amine(out) = ADP + Orthophosphate
            + Quaternary amine(in)
SUBSTRATE   ATP
            H2O
            Quaternary amine
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports betaine and glycine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.32
            ExPASy - ENZYME nomenclature database: 3.6.3.32
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.32
///
ENTRY       EC 3.6.3.33
NAME        Vitamin B12-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (vitamin B12-importing)
REACTION    ATP + H2O + Vitamin B12(out) = ADP + Orthophosphate + Vitamin
            B12(in)
SUBSTRATE   ATP
            H2O
            Vitamin B12
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports cobalamin derivatives.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.33
            ExPASy - ENZYME nomenclature database: 3.6.3.33
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.33
///
ENTRY       EC 3.6.3.34
NAME        Iron-chelate-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (iron-chelate-importing)
REACTION    ATP + H2O + Iron chelate(out) = ADP + Orthophosphate + Iron
            chelate(in)
SUBSTRATE   ATP
            H2O
            Iron chelate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and
            other siderophores.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.34
            ExPASy - ENZYME nomenclature database: 3.6.3.34
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.34
///
ENTRY       EC 3.6.3.35
NAME        Manganese-transporting ATPase
            ABC-type manganese permease complex
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (manganese-importing)
REACTION    ATP + H2O + Mn2+(out) = ADP + Orthophosphate + Mn2+(in)
SUBSTRATE   ATP
            H2O
            Mn2+
            Zn2+
            Iron chelate
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports Mn2+, Zn2+ and iron chelates.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.35
            ExPASy - ENZYME nomenclature database: 3.6.3.35
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.35
///
ENTRY       EC 3.6.3.36
NAME        Taurine-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (taurine-importing)
REACTION    ATP + H2O + Taurine(out) = ADP + Orthophosphate + Taurine(in)
SUBSTRATE   ATP
            H2O
            Taurine
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A bacterial enzyme
            that imports taurine.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.36
            ExPASy - ENZYME nomenclature database: 3.6.3.36
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.36
///
ENTRY       EC 3.6.3.37
NAME        Guanine-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (guanine-importing)
REACTION    ATP + H2O + Guanine(out) = ADP + Orthophosphate + Guanine(in)
SUBSTRATE   ATP
            H2O
            Guanine
            Tryptophan
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A eukaryotic enzyme
            that imports guanine and tryptophan (it contains a single ATP-
            binding site).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.37
            ExPASy - ENZYME nomenclature database: 3.6.3.37
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.37
///
ENTRY       EC 3.6.3.38
NAME        Capsular-polysaccharide-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (capsular-polysaccharide-exporting)
REACTION    ATP + H2O + Capsular polysaccharide(in) = ADP + Orthophosphate +
            Capsular polysaccharide(out)
SUBSTRATE   ATP
            H2O
            Capsular polysaccharide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An enzyme that
            exports capsular polysaccharide from Gram-negative bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.38
            ExPASy - ENZYME nomenclature database: 3.6.3.38
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.38
///
ENTRY       EC 3.6.3.39
NAME        Lipopolysaccharide-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (lipopolysaccharide-exporting)
REACTION    ATP + H2O + Lipopolysaccharide(in) = ADP + Orthophosphate +
            Lipopolysaccharide(out)
SUBSTRATE   ATP
            H2O
            Lipopolysaccharide
            Lipo-oligosaccharide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Enzymes of Gram-
            negative bacteria that export lipo-oligosaccharides and
            lipopolysaccharides.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.39
            ExPASy - ENZYME nomenclature database: 3.6.3.39
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.39
///
ENTRY       EC 3.6.3.40
NAME        Teichoic-acid-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (teichoic-acid-exporting)
REACTION    ATP + H2O + Teichoic acid(in) = ADP + Orthophosphate + Teichoic
            acid(out)
SUBSTRATE   ATP
            H2O
            Teichoic acid
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An enzyme found in
            Gram-positive bacteria that exports teichoic acid.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.40
            ExPASy - ENZYME nomenclature database: 3.6.3.40
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.40
///
ENTRY       EC 3.6.3.41
NAME        Heme-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (heme-exporting)
REACTION    ATP + H2O + Heme(in) = ADP + Orthophosphate + Heme(out)
SUBSTRATE   ATP
            H2O
            Heme
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An enzyme found in
            Gram-negative bacteria that exports heme.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.41
            ExPASy - ENZYME nomenclature database: 3.6.3.41
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.41
///
ENTRY       EC 3.6.3.42
NAME        beta-Glucan-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (beta-glucan-exporting)
REACTION    ATP + H2O + beta-Glucan(in) = ADP + Orthophosphate +
            beta-Glucan(out)
SUBSTRATE   ATP
            H2O
            beta-Glucan
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An enzyme found in
            Gram-negative bacteria that exports beta-glucan.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.42
            ExPASy - ENZYME nomenclature database: 3.6.3.42
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.42
///
ENTRY       EC 3.6.3.43
NAME        Peptide-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (peptide-exporting)
REACTION    ATP + H2O + Peptide(in) = ADP + Orthophosphate + Peptide(out)
SUBSTRATE   ATP
            H2O
            Peptide
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A family of enzymes
            that exports alpha-hemolysin, cyclolysin, colicin V and 
            siderophores from Gram-negative bacteria, and bacteriocin, 
            subtilin, competence factor and pediocin from Gram-positive 
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.43
            ExPASy - ENZYME nomenclature database: 3.6.3.43
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.43
///
ENTRY       EC 3.6.3.44
NAME        Xenobiotic-transporting ATPase
            Multidrug-resistance protein
            P-glycoprotein
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (xenobiotic-exporting)
REACTION    ATP + H2O + Xenobiotic(in) = ADP + Orthophosphate +
            Xenobiotic(out)
SUBSTRATE   ATP
            H2O
            Xenobiotic
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. Enzymes of Gram-
            positive bacteria and eukaryotic cells that export a number of
            drugs, with unusual specificity, covering various groups of
            unrelated substances, while ignoring some that are closely related
            structurally. Several distinct enzymes may be present in a single
            eukaryotic cell. Many of them transport glutathione conjugates with
            drugs. Some also show some 'flippase' (Mg2+-ATPase; EC 3.6.3.1)
            activity.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.44
            ExPASy - ENZYME nomenclature database: 3.6.3.44
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.44
///
ENTRY       EC 3.6.3.45
NAME        Steroid-transporting ATPase
            Pleiotropic-drug-resistance protein
            PDR protein
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (steroid-exporting)
REACTION    ATP + H2O + Steroid(in) = ADP + Orthophosphate + Steroid(out)
SUBSTRATE   ATP
            H2O
            Steroid
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A yeast protein that
            exports a variety of xenobiotics, especially steroids.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.45
            ExPASy - ENZYME nomenclature database: 3.6.3.45
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.45
///
ENTRY       EC 3.6.3.46
NAME        Cadmium-transporting ATPase
            Yeast cadmium factor
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (heavy-metal-exporting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
            Cd2+
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A yeast enzyme that
            exports some heavy metals, especially Cd2+, from the cytosol into
            the vacuole.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.46
            ExPASy - ENZYME nomenclature database: 3.6.3.46
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.46
///
ENTRY       EC 3.6.3.47
NAME        Fatty-acyl-CoA-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (fatty-acyl-CoA-transporting)
REACTION    ATP + H2O + Fatty acyl CoA(cis) = ADP + Orthophosphate + Fatty
            acyl CoA(trans)
SUBSTRATE   ATP
            H2O
            Fatty acyl CoA
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An animal and yeast
            enzyme that transports fatty acyl CoA into and out of peroxisomes.
            In humans, it is associated with Zellweger's syndrome.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.47
            ExPASy - ENZYME nomenclature database: 3.6.3.47
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.47
///
ENTRY       EC 3.6.3.48
NAME        alpha-Factor-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (alpha-factor-transporting)
REACTION    ATP + H2O + alpha-Factor(in) = ADP + Orthophosphate +
            alpha-Factor(out)
SUBSTRATE   ATP
            H2O
            alpha-Factor
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. A yeast enzyme that
            exports the alpha-factor sex pheromone.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.48
            ExPASy - ENZYME nomenclature database: 3.6.3.48
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.48
///
ENTRY       EC 3.6.3.49
NAME        Channel-conductance-controlling ATPase
            Cystic-fibrosis membrane-conductance-regulating protein
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (channel-conductance-controlling)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     ABC-type (ATP-binding cassette-type) ATPase, characterised by the
            presence of two similar ATP-binding domains. Does not undergo
            phosphorylation during the transport process. An animal enzyme that
            is active in forming a chloride channel, the absence of which
            brings about cystic fibrosis. It is also involved in the
            functioning of other transmembrane channels.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.49
            ExPASy - ENZYME nomenclature database: 3.6.3.49
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.49
///
ENTRY       EC 3.6.3.50
NAME        Protein-secreting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (protein-secreting)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is
            involved in protein transport. There are several families of
            enzymes included here, e.g. ATP-hydrolysing enzymes of the general
            secretory pathway (Sec or Type II), of the virulence-related
            secretory pathway (Type III) and of the conjugal DNA-protein
            transfer pathway (Type IV). Type II enzymes occur in bacteria,
            archaea and eucarya,whereas type III and type IV enzymes occur in
            bacteria where they form components of a multi-subunit complex.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.50
            ExPASy - ENZYME nomenclature database: 3.6.3.50
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.50
///
ENTRY       EC 3.6.3.51
NAME        Mitochondrial protein-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (mitochondrial protein-importing)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase
            involved in the transport of proteins or preproteins into
            mitochondria using the TIM protein complex. (TIM is the protein
            transport machinery of the inner mitochondrial membrane that
            contains three essential Tim proteins: Tim17 and Tim23 are thought
            to build a preprotein translocation channel while Tim44 interacts
            transiently with the matrix heat-shock protein Hsp70 to form an
            ATP-driven import motor.)
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.51
            ExPASy - ENZYME nomenclature database: 3.6.3.51
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.51
///
ENTRY       EC 3.6.3.52
NAME        Chloroplast protein-transporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (chloroplast protein-importing)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase that is
            involved in protein transport. Involved in the transport of
            proteins or preproteins into chloroplast stroma (several ATPases
            may participate in this process).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.52
            ExPASy - ENZYME nomenclature database: 3.6.3.52
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.52
///
ENTRY       EC 3.6.3.53
NAME        Ag+-exporting ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Catalysing transmembrane movement of substances
SYSNAME     ATP phosphohydrolase (Ag+-exporting)
REACTION    ATP + H2O + Ag+(in) = ADP + Orthophosphate + Ag+(out)
SUBSTRATE   ATP
            H2O
            Ag+
PRODUCT     ADP
            Orthophosphate
COMMENT     A P-type ATPase that exports Ag+ ions from pathogenic
            microorganisms as well as from some animal tissues.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.3.53
            ExPASy - ENZYME nomenclature database: 3.6.3.53
            WIT (What Is There) Metabolic Reconstruction: 3.6.3.53
///
ENTRY       EC 3.6.4.1
NAME        Myosin ATPase
            Actomyosin
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (actin-translocating)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Proteins of the contractile apparatus of muscle and nonmuscle
            cells; myosin molecule consists of two heavy chains (about 200 kDa)
            and two pairs of light chains (15-27 kDa). The head region of the
            heavy chain contains actin- and ATP-binding sites. ATP hydrolysis
            provides energy for actomyosin contraction.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.1
            ExPASy - ENZYME nomenclature database: 3.6.4.1
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.1
///
ENTRY       EC 3.6.4.2
NAME        Dynein ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (tubulin-translocating)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A multisubunit protein complex associated with microtubules.
            Hydrolysis of ATP provides energy for the movement of organelles
            (endosomes, lysosomes, mitochondria) along microtubules to the
            centrosome towards the microtubule's minus end. It also functions
            in the movement of eukaryotic flagella and cilia. It consists of
            two heavy chains (about 500 kDa), three-four intermediate chains
            (about 70 kDa) and four light chains (about 50 kDa).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.2
            ExPASy - ENZYME nomenclature database: 3.6.4.2
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.2
///
ENTRY       EC 3.6.4.3
NAME        Microtubule-severing ATPase
            Katanin
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (tubulin-dimerizing)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Another member of the AAA-ATPase family, active in splitting
            microtubules into tubulin dimers in the centrosome.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.3
            ExPASy - ENZYME nomenclature database: 3.6.4.3
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.3
///
ENTRY       EC 3.6.4.4
NAME        Plus-end-directed kinesin ATPase
            Kinesin
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     Kinesin ATP phosphohydrolase (plus-end-directed)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Microtubular motor protein, involved in organelle movement, in
            mitosis and meiosis. In contrast to dynein, it moves along
            microtubules towards the plus end. Composed of two heavy (alpha) 
            chains (110 kDa) and two or more light (beta) chains (65-75 kDa). 
            Also hydrolyses GTP.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.4
            ExPASy - ENZYME nomenclature database: 3.6.4.4
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.4
///
ENTRY       EC 3.6.4.5
NAME        Minus-end-directed kinesin ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     Kinesin ATP phosphohydrolase (minus-end-directed)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Structurally almost identical to EC 3.6.4.3 (microtubule-severing
            ATPase) but the movement it catalyses is towards the minus end of
            microtubules.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.5
            ExPASy - ENZYME nomenclature database: 3.6.4.5
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.5
///
ENTRY       EC 3.6.4.6
NAME        Vesicle-fusing ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (vesicle-fusing)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     A large family of ATP-hydrolysing enzymes involved in the
            heterotypic fusion of membrane vesicles with target membranes and
            the homotypic fusion of various membrane compartments. They belong
            to the AAA-type (ATPase associated with a variety of cell
            activities) ATPase superfamily. They include peroxin, which
            apparently is involved in Zellweger's syndrome.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.6
            ExPASy - ENZYME nomenclature database: 3.6.4.6
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.6
///
ENTRY       EC 3.6.4.7
NAME        Peroxisome-assembly ATPase
            Peroxisome assembly factor-2
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (peroxisome-assembling)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     An extremely diversified group of enzymes that use the energy of
            ATP hydrolysis to import and assemble peroxisome components into
            the organelle. Their molecular masses range from 25 to 600 kDa.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.7
            ExPASy - ENZYME nomenclature database: 3.6.4.7
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.7
///
ENTRY       EC 3.6.4.8
NAME        Proteasome ATPase
            RP triple-A protein
            RP triphosphatase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (polypeptide-degrading)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-
            end-directed kinesin ATPase), is involved in channel gating and
            polypeptide unfolding before proteolysis in the proteasome. Six
            ATPase subunits are present in the regulatory particle (RP) of 26S
            proteasome.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.8
            ExPASy - ENZYME nomenclature database: 3.6.4.8
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.8
///
ENTRY       EC 3.6.4.9
NAME        Chaperonin ATPase
            Chaperonin
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (polypeptide-unfolding)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     Multisubunit proteins with 2x7 (Type I, in most cells) or 2x8 (Type
            II, in Archaea) ATP-binding sites involved in maintaining an
            unfolded polypeptide structure before folding or to entry into
            mitochondria and chloroplasts. Molecular masses of subunits ranges
            from 10-90 kDa. They are a subclass of molecular chaperones that
            are related to EC 3.6.4.9 (proteasome ATPase).
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.9
            ExPASy - ENZYME nomenclature database: 3.6.4.9
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.9
///
ENTRY       EC 3.6.4.10
NAME        Non-chaperonin molecular chaperone ATPase
            Molecular chaperone Hsc70 ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (polypeptide-polymerizing)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     This is a highly diverse group of enzymes that perform many
            functions that are similar to those of chaperonins. They comprise a
            number of heat-shock-cognate proteins. They are also active in
            clathrin uncoating and in the oligomerization of actin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.10
            ExPASy - ENZYME nomenclature database: 3.6.4.10
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.10
///
ENTRY       EC 3.6.4.11
NAME        Nucleoplasmin ATPase
CLASS       Hydrolases
            Acting on acid anhydrides
            Involved in cellular and subcellular movement
SYSNAME     ATP phosphohydrolase (nucleosome-assembling)
REACTION    ATP + H2O = ADP + Orthophosphate
SUBSTRATE   ATP
            H2O
PRODUCT     ADP
            Orthophosphate
COMMENT     An acidic nuclear protein that is active in the ATP-dependent
            assembly of nucleosome cores, in decondensation of sperm chromatin
            and in other histone-involving processes.
DBLINKS     IUBMB Enzyme Nomenclature: 3.6.4.11
            ExPASy - ENZYME nomenclature database: 3.6.4.11
            WIT (What Is There) Metabolic Reconstruction: 3.6.4.11
///
ENTRY       EC 3.7.1.1
NAME        Oxaloacetase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     Oxaloacetate acetylhydrolase
REACTION    Oxaloacetate + H2O = Oxalate + Acetate
SUBSTRATE   Oxaloacetate
            H2O
PRODUCT     Oxalate
            Acetate
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.1
            ExPASy - ENZYME nomenclature database: 3.7.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.1
            BRENDA, the Enzyme Database: 3.7.1.1
///
ENTRY       EC 3.7.1.2
NAME        Fumarylacetoacetase
            beta-Diketonase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     4-Fumarylacetoacetate fumarylhydrolase
REACTION    4-Fumarylacetoacetate + H2O = Acetoacetate + Fumarate
SUBSTRATE   4-Fumarylacetoacetate
            H2O
            3,5-Dioxo acid
            2,4-DIoxo acid
PRODUCT     Acetoacetate
            Fumarate
COMMENT     Also acts on other 3,5- and 2,4-dioxo acids.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00643  Styrene degradation
GENES       PAE: PA2008(fahA)
            CEL: K10C2.4
            DME: CG14993
            MMU: 95482(Fah)
            HSA: 2184(FAH)
DISEASE     MIM: 276700  Fumarylacetoacetase
STRUCTURES  PDB: 1HYO  1QCN  1QCO  1QQJ  
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.2
            ExPASy - ENZYME nomenclature database: 3.7.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.2
            BRENDA, the Enzyme Database: 3.7.1.2
            SCOP (Structural Classification of Proteins): 3.7.1.2
///
ENTRY       EC 3.7.1.3
NAME        Kynureninase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     L-Kynurenine hydrolase
REACTION    L-Kynurenine + H2O = Anthranilate + L-Alanine
SUBSTRATE   L-Kynurenine
            H2O
            3-Hydroxykynurenine
            (3-Arylcarbonyl)-alanine
PRODUCT     Anthranilate
            L-Alanine
            3-Hydroxyanthranilate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on 3'-hydroxykynurenine
            and some other (3-arylcarbonyl)-alanines.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
GENES       MLO: mll0621
            SCE: YLR231C(YLR231C)
            CEL: C15H9.7
            HSA: 8942(KYNU)
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.3
            ExPASy - ENZYME nomenclature database: 3.7.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.3
            BRENDA, the Enzyme Database: 3.7.1.3
///
ENTRY       EC 3.7.1.4
NAME        Phloretin hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     2',4,4'6'-Tetrahydroxydehydrochalcone 1,3,5-trihydroxy-
            $benzenehydrolase
REACTION    Phloretin + H2O = Phloretate + Phloroglucinol
SUBSTRATE   Phloretin
            H2O
PRODUCT     Phloretate
            Phloroglucinol
COMMENT     Also hysrolyses other C-acylated phenols related to phloretin.
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.4
            ExPASy - ENZYME nomenclature database: 3.7.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.4
            BRENDA, the Enzyme Database: 3.7.1.4
///
ENTRY       EC 3.7.1.5
NAME        Acylpyruvate hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     3-Acylpyruvate acylhydrolase
REACTION    a 3-Acylpyruvate + H2O = a Carboxylate + Pyruvate
SUBSTRATE   3-Acylpyruvate
            H2O
            Formylpyruvate
PRODUCT     Carboxylate
            Pyruvate
COMMENT     Acts on formylpyruvate, 2,4-dioxopentanoate, 2,4-dioxohexanoate
            and 2,4-dioxoheptanoate.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.5
            ExPASy - ENZYME nomenclature database: 3.7.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.5
            BRENDA, the Enzyme Database: 3.7.1.5
///
ENTRY       EC 3.7.1.6
NAME        Acetylpyruvate hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     2,4-Dioxopentanoate acetylhydrolase
REACTION    Acetylpyruvate + H2O = Acetate + Pyruvate
SUBSTRATE   Acetylpyruvate
            H2O
PRODUCT     Acetate
            Pyruvate
COMMENT     Highly specific; does not act on pyruvate, oxaloacetate,
            maleylpyruvate, fumarylpyruvate or acetylacetone.
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.6
            ExPASy - ENZYME nomenclature database: 3.7.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.6
            UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.6
            BRENDA, the Enzyme Database: 3.7.1.6
///
ENTRY       EC 3.7.1.7
NAME        beta-Diketone hydrolase
            Oxidized PVA hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     Nonane-4,6-dione acylhydrolase
REACTION    Nonane-4,6-dione + H2O = Pentan-2-one + Butanoate
SUBSTRATE   Nonane-4,6-dione
            H2O
PRODUCT     Pentan-2-one
            Butanoate
COMMENT     Also acts on the product of the action of EC 1.1.3.18 on polyvinyl
            alcohols; involved in the bacterial degradation of polyvinyl
            alcohol.
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.7
            ExPASy - ENZYME nomenclature database: 3.7.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.7
            BRENDA, the Enzyme Database: 3.7.1.7
///
ENTRY       EC 3.7.1.8
NAME        2,6-Dioxo-6-phenylhexa-3-enoate hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     2,6-Dioxo-6-phenylhexa-3-enoate benzoylhydrolase
REACTION    2,6-Dioxo-6-phenylhexa-3-enoate + H2O = Benzoate +
            2-Oxopent-4-enoate
SUBSTRATE   2,6-Dioxo-6-phenylhexa-3-enoate
            H2O
PRODUCT     Benzoate
            2-Oxopent-4-enoate
COMMENT     Cleaves the products from biphenol, 3-isopropylcatechol and
            3-methylcatechol produced by EC 1.13.11.39 by ring-fission at a
            -CO-C bond. Involved in the breakdown of biphenyl-related
            compounds by Pseudomonas sp.
PATHWAY     PATH: MAP00621  Biphenyl degradation
            PATH: MAP00628  Fluorene degradation
STRUCTURES  PDB: 1C4X  
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.8
            ExPASy - ENZYME nomenclature database: 3.7.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.8
            UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.8
            BRENDA, the Enzyme Database: 3.7.1.8
            SCOP (Structural Classification of Proteins): 3.7.1.8
///
ENTRY       EC 3.7.1.9
NAME        2-Hydroxymuconate-semialdehyde hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     2-Hydroxymuconate-semialdehyde formylhydrolase
REACTION    2-Hydroxymuconate semialdehyde + H2O = Formate + Oxopent-4-enoate;
            2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde + H2O = Formate +
            2-Oxohex-trans-4-enoate
SUBSTRATE   2-Hydroxymuconate semialdehyde
            H2O
            2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde
PRODUCT     Formate
            Oxopent-4-enoate
            2-Oxohex-trans-4-enoate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00624  Xylene degradation
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00627  1,4-Dichlorobenzene degradation
            PATH: MAP00629  Carbazole degradation
            PATH: MAP00643  Styrene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.9
            ExPASy - ENZYME nomenclature database: 3.7.1.9
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.9
            UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.9
            BRENDA, the Enzyme Database: 3.7.1.9
///
ENTRY       EC 3.7.1.10
NAME        Cyclohexane-1,3-dione hydrolase
CLASS       Hydrolases
            Acting on carbon-carbon bonds
            In ketonic substances
SYSNAME     Cyclohexane-1,3-dione acylhydrolase (decyclizing)
REACTION    Cyclohexane-1,3-dione + H2O = 5-Oxohexanoate
SUBSTRATE   Cyclohexane-1,3-dione
            H2O
PRODUCT     5-Oxohexanoate
COMMENT     Highly specific; does not act on other dione derivatives of
            cyclohexane, cyclopentane or cycloheptane.
DBLINKS     IUBMB Enzyme Nomenclature: 3.7.1.10
            ExPASy - ENZYME nomenclature database: 3.7.1.10
            WIT (What Is There) Metabolic Reconstruction: 3.7.1.10
            BRENDA, the Enzyme Database: 3.7.1.10
///
ENTRY       EC 3.8.1.1
NAME        Alkylhalidase
            Halogenase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     Alkyl-halide halidohydrolase
REACTION    Bromochloromethane + H2O = Formaldehyde + Bromide + Chloride
SUBSTRATE   Bromochloromethane
            H2O
PRODUCT     Formaldehyde
            Bromide
            Chloride
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.1
            ExPASy - ENZYME nomenclature database: 3.8.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.1
            BRENDA, the Enzyme Database: 3.8.1.1
///
ENTRY       EC 3.8.1.2
NAME        2-Haloacid dehalogenase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     2-Haloacid halidohydrolase
REACTION    (S)-2-Haloacid + H2O = (R)-2-Hydroxyacid + Halide
SUBSTRATE   (S)-2-Haloacid
            H2O
PRODUCT     (R)-2-Hydroxyacid
            Halide
COMMENT     Acts on acids of short chain lengths, C2 to C4, with
            inversion of configuration at C-2.
GENES       SME: SMa1851
            MJA: MJ1437
            PAB: PAB1316
            SSO: SSO0726 SSO1896 SSO2028 SSO2159
            STO: ST0436
STRUCTURES  PDB: 1ZRN  1AQ6  1JUD  1QH9  1QQ5  1QQ6  1QQ7  1ZRM  
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.2
            ExPASy - ENZYME nomenclature database: 3.8.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.2
            BRENDA, the Enzyme Database: 3.8.1.2
            SCOP (Structural Classification of Proteins): 3.8.1.2
///
ENTRY       EC 3.8.1.3
NAME        Haloacetate dehalogenase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     Haloacetate halidohydrolase
REACTION    Haloacetate + H2O = Glycolate + Halide
SUBSTRATE   Haloacetate
            H2O
PRODUCT     Glycolate
            Halide
PATHWAY     PATH: MAP00631  1,2-Dichloroethane degradation
GENES       SSO: SSO1159
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.3
            ExPASy - ENZYME nomenclature database: 3.8.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.3
            UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.3
            BRENDA, the Enzyme Database: 3.8.1.3
///
ENTRY       EC 3.8.1.4
NAME        Thyroxine deiodinase
            Thyroxine 5-deiodinase
            Diiodothyronine 5'-deiodinase
            Iodothyronine outer ring monodeiodinase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     L-Thyroxine iodohydrolase (reducing)
REACTION    L-Thyroxine + AH2 = 3,5,3'-L-Triiodo-L-thyronine + Iodide +
            A + H+
SUBSTRATE   L-Thyroxine
            AH2
PRODUCT     3,5,3'-L-Triiodo-L-thyronine
            Iodide
            A
            H+
COMMENT     A group of enzymes, removing iodine atoms sequentially
            from thyroxine. Distinct enzymes may exist acting on the
            inner and outer rings of iodinated thyronine.
GENES       HSA: 1733(DIO1) 1734(DIO2) 1735(DIO3)
DISEASE     MIM: 147892  Deiodinase, iodothyronine, type I
            MIM: 601038  Deiodinase, iodothyronine, type 3
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00194  [LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-
                         C-[GATPLVE]-[PHYWSTA]-C-x(6)-[LIVMFYWT]
            PS: PS01205  R-P-L-[IV]-x-[NS]-F-G-S-[CA]-T-C-P-x-F
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.4
            ExPASy - ENZYME nomenclature database: 3.8.1.4
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.4
            BRENDA, the Enzyme Database: 3.8.1.4
///
ENTRY       EC 3.8.1.5
NAME        Haloalkane dehalogenase
            1-Chlorohexane halidohydrolase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     1-Haloalkane halidohydrolase
REACTION    1-Haloalkane + H2O = a Primary alcohol + Halide
SUBSTRATE   1-Haloalkane
            H2O
            Haloalcohol
            Haloalkene
            Haloaromatic compound
PRODUCT     Primary alcohol
            Halide
COMMENT     Acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes
            and some haloaromatic compounds.
PATHWAY     PATH: MAP00631  1,2-Dichloroethane degradation
            PATH: MAP00641  3-Chloroacrylic acid degradation
GENES       CCR: CC1175
            MTU: Rv2296
            MTC: MT2353
STRUCTURES  PDB: 1BE0  1B6G  1HDE  1BEE  1BEZ  1BN6  1BN7  1CIJ  1CQW  1CV2  
                 1D07  1EDB  1EDD  1EDE  2DHC  2DHD  2DHE  2EDA  2EDC  
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.5
            ExPASy - ENZYME nomenclature database: 3.8.1.5
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.5
            UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.5
            BRENDA, the Enzyme Database: 3.8.1.5
            SCOP (Structural Classification of Proteins): 3.8.1.5
///
ENTRY       EC 3.8.1.6
NAME        4-Chlorobenzoate dehalogenase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     4-Chlorobenzoate chlorohydrolase
REACTION    4-Chlorobenzoate + H2O = 4-Hydroxybenzoate + Chloride
SUBSTRATE   4-Chlorobenzoate
            H2O
PRODUCT     4-Hydroxybenzoate
            Chloride
COMMENT     Catalyses the first step in the degradation of chlorobenzoate in
            Pseudomonas.
STRUCTURES  PDB: 1BVQ  1JXZ  1NZY  
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.6
            ExPASy - ENZYME nomenclature database: 3.8.1.6
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.6
            BRENDA, the Enzyme Database: 3.8.1.6
            SCOP (Structural Classification of Proteins): 3.8.1.6
///
ENTRY       EC 3.8.1.7
NAME        4-Chlorobenzoyl-CoA dehalogenase
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
REACTION    4-Chlorobenzoyl-CoA + H2O = 4-Hydroxybenzoyl-CoA + Chloride
SUBSTRATE   4-Chlorobenzoyl-CoA
            H2O
PRODUCT     4-Hydroxybenzoyl-CoA
            Chloride
COMMENT     Specific for dehalogenation at the 4-position.
            Can dehalogenate substrates bearing fluorine, chlorine, bromine and
            iodine in the 4-position.
            This enzyme is part of the bacterial 2,4-dichlorobenzoate
            degradation pathway.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.7
            ExPASy - ENZYME nomenclature database: 3.8.1.7
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.7
            UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.7
///
ENTRY       EC 3.8.1.8
NAME        Atrazine chlorohydrolase
            AtzA
CLASS       Hydrolases
            Acting on halide bonds
            In C-halide compounds
SYSNAME     Atrazine chlorohydrolase
REACTION    Atrazine + H2O = 4-(Ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-
            triazine + HCl
SUBSTRATE   Atrazine
            H2O
PRODUCT     4-(Ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine
            HCl
COMMENT     Involved in the degradation of the herbicide atrazine, 2-chloro-4-
            (ethylamino)-6-(isopropylamino)-1,3,5-triazine, in bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.1.8
            ExPASy - ENZYME nomenclature database: 3.8.1.8
            WIT (What Is There) Metabolic Reconstruction: 3.8.1.8
            UM-BBD (Biocatalysis/Biodegradation Database): 3.8.1.8
///
ENTRY       EC 3.8.2.1
NAME        Transferred to EC 3.1.8.2
            Diisopropyl-fluorophosphatase
CLASS       Hydrolases
            Acting on halide bonds
COMMENT     Transferred entry.
            Now listed as EC 3.1.8.2 - Diisopropyl-fluorophosphatase.
DBLINKS     IUBMB Enzyme Nomenclature: 3.8.2.1
            ExPASy - ENZYME nomenclature database: 3.8.2.1
            WIT (What Is There) Metabolic Reconstruction: 3.8.2.1
///
ENTRY       EC 3.9.1.1
NAME        Phosphoamidase
CLASS       Hydrolases
            Acting on phosphorus-nitrogen bonds
SYSNAME     Phosphamide hydrolase
REACTION    N-Phosphocreatine + H2O = Creatine + Orthophosphate
SUBSTRATE   N-Phosphocreatine
            H2O
PRODUCT     Creatine
            Orthophosphate
COMMENT     Also acts on N-phospho-arginine and other phosphoamides.
            Possibly identical with EC 3.1.3.9 or 3.1.3.16.
DBLINKS     IUBMB Enzyme Nomenclature: 3.9.1.1
            ExPASy - ENZYME nomenclature database: 3.9.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.9.1.1
            BRENDA, the Enzyme Database: 3.9.1.1
///
ENTRY       EC 3.10.1.1
NAME        N-Sulfoglucosamine sulfohydrolase
            Sulfoglucosamine sulfamidase
CLASS       Hydrolases
            Acting on sulfur-nitrogen bonds
SYSNAME     N-Sulfo-D-glucosamine sulfohydrolase
REACTION    N-Sulfo-D-glucosamine + H2O = D-Glucosamine + Sulfate
SUBSTRATE   N-Sulfo-D-glucosamine
            H2O
PRODUCT     D-Glucosamine
            Sulfate
GENES       HSA: 6448(SGSH)
MOTIF       PS: PS00149  G-[YV]-x-[ST]-x(2)-[IVAS]-G-K-x(0,1)-[FYWMK]-[HL]
            PS: PS00523  [SAP]-[LIVMST]-[CS]-[STAC]-P-[STA]-R-x(2)-[LIVMFW](2)-
                         [TAR]-G
DBLINKS     IUBMB Enzyme Nomenclature: 3.10.1.1
            ExPASy - ENZYME nomenclature database: 3.10.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.10.1.1
            BRENDA, the Enzyme Database: 3.10.1.1
///
ENTRY       EC 3.10.1.2
NAME        Cyclamate sulfohydrolase
            Cyclamate sulfamatase
            Cyclamate sulfamidase
CLASS       Hydrolases
            Acting on sulfur-nitrogen bonds
SYSNAME     Cyclohexylsulfamate sulfohydrolase
REACTION    Cyclohexylsulfamate + H2O = Cyclohexylamine + Sulfate
SUBSTRATE   Cyclohexylsulfamate
            H2O
PRODUCT     Cyclohexylamine
            Sulfate
COMMENT     Also readily hydrolyses aliphatic sulfamates with 3 to 8 carbons.
DBLINKS     IUBMB Enzyme Nomenclature: 3.10.1.2
            ExPASy - ENZYME nomenclature database: 3.10.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.10.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 3.10.1.2
            BRENDA, the Enzyme Database: 3.10.1.2
///
ENTRY       EC 3.11.1.1
NAME        Phosphonoacetaldehyde hydrolase
CLASS       Hydrolases
            Acting on carbon-phosphorus bonds
SYSNAME     2-Oxoethylphosphonate phosphonohydrolase
REACTION    Phosphonoacetaldehyde + H2O = Acetaldehyde + Orthophosphate
SUBSTRATE   Phosphonoacetaldehyde
            H2O
PRODUCT     Acetaldehyde
            Orthophosphate
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.11.1.1
            ExPASy - ENZYME nomenclature database: 3.11.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.11.1.1
            BRENDA, the Enzyme Database: 3.11.1.1
///
ENTRY       EC 3.11.1.2
NAME        Phosphonoacetate hydrolase
CLASS       Hydrolases
            Acting on carbon-phosphorus bonds
REACTION    Phosphonoacetate + H2O = Acetate + Phosphate
SUBSTRATE   Phosphonoacetate
            H2O
PRODUCT     Acetate
            Phosphate
COFACTOR    Zinc
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.11.1.2
            ExPASy - ENZYME nomenclature database: 3.11.1.2
            WIT (What Is There) Metabolic Reconstruction: 3.11.1.2
///
ENTRY       EC 3.12.1.1
NAME        Trithionate hydrolase
CLASS       Hydrolases
            Acting on sulfur-sulfur bonds
SYSNAME     Trithionate thiosulfohydrolase
REACTION    Trithionate + H2O = Thiosulfate + Sulfate + 2 H+
SUBSTRATE   Trithionate
            H2O
PRODUCT     Thiosulfate
            Sulfate
            H+
PATHWAY     PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 3.12.1.1
            ExPASy - ENZYME nomenclature database: 3.12.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.12.1.1
            BRENDA, the Enzyme Database: 3.12.1.1
///
ENTRY       EC 4.1.1.1
NAME        Pyruvate decarboxylase
            alpha-Carboxylase
            Pyruvic decarboxylase
            alpha-Ketoacid carboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2-Oxo-acid carboxy-lyase
REACTION    a 2-Oxo acid = an Aldehyde + CO2;
            Pyruvate = Acetaldehyde + CO2
SUBSTRATE   2-Oxo acid
            Pyruvate
PRODUCT     Aldehyde
            CO2
            Acyloin
            Acetaldehyde
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein. Also catalyses acyloin formation.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       SAU: SA0182
            SAV: SAV0183
            MTU: Rv0853c(pdc)
            MTC: MT0876
            MLE: ML2167(pdc)
            SCE: YDL080C(THI3) YGR087C(PDC6) YLR044C(PDC1) YLR134W(PDC5)
            SPO: SPAC13A11.06 SPAC186.09(spac186.09) SPAC1F8.07C(spac1f8.07c)
                 SPAC3G9.11C(spac3g9.11c)
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
STRUCTURES  PDB: 1PVD  1PYD  1QPB  1ZPD  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.1
            ExPASy - ENZYME nomenclature database: 4.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.1
            BRENDA, the Enzyme Database: 4.1.1.1
            SCOP (Structural Classification of Proteins): 4.1.1.1
///
ENTRY       EC 4.1.1.2
NAME        Oxalate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Oxalate carboxy-lyase
REACTION    Oxalate = Formate + CO2
SUBSTRATE   Oxalate
PRODUCT     Formate
            CO2
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.2
            ExPASy - ENZYME nomenclature database: 4.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.2
            BRENDA, the Enzyme Database: 4.1.1.2
///
ENTRY       EC 4.1.1.3
NAME        Oxaloacetate decarboxylase
            Oxaloacetate beta-decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Oxaloacetate carboxy-lyase
REACTION    Oxaloacetate = Pyruvate + CO2
SUBSTRATE   Oxaloacetate
PRODUCT     Pyruvate
            CO2
COFACTOR    Biotin
            Sodium
            Manganese
INHIBITOR   Acetyl-CoA
COMMENT     The enzyme from Klebsiella aerogenes is a biotinyl-protein and
            requires Na+; while linked to phospholipid vesicles it acts as
            a sodium pump. Some animal enzymes require Mn2+.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00620  Pyruvate metabolism
GENES       PMU: PM1421 PM1422 PM1423
            VCH: VC0549 VC0550 VC0551 VC0792 VC0794
            SPY: SPy1174 SPy1191(oadA)
            TPA: TP0056 TP0057
            AAE: aq_1614(oadA)
            TMA: TM0128 TM0880
            AFU: AF1252(oadA) AF2084(oadB) AF2085
            PHO: PH0834
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.3
            ExPASy - ENZYME nomenclature database: 4.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.3
            BRENDA, the Enzyme Database: 4.1.1.3
///
ENTRY       EC 4.1.1.4
NAME        Acetoacetate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Acetoacetate carboxy-lyase
REACTION    Acetoacetate + H+ = Acetone + CO2
SUBSTRATE   Acetoacetate
            H+
PRODUCT     Acetone
            CO2
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.4
            ExPASy - ENZYME nomenclature database: 4.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.4
            BRENDA, the Enzyme Database: 4.1.1.4
///
ENTRY       EC 4.1.1.5
NAME        Acetolactate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     (S)-2-Hydroxy-2-methyl-3-oxobutanoate carboxy-lyase
REACTION    (S)-2-Hydroxy-2-methyl-3-oxobutanoate = (R)-2-Acetoin + CO2
SUBSTRATE   (S)-2-Hydroxy-2-methyl-3-oxobutanoate
PRODUCT     (R)-2-Acetoin
            CO2
PATHWAY     PATH: MAP00650  Butanoate metabolism
            PATH: MAP00660  C5-Branched dibasic acid metabolism
GENES       VCH: VC1589
            BSU: BG10472(alsD)
            SAU: SA2007
            SAV: SAV2192(alsD)
            LLA: L0321(aldB)
            SPN: SP1392
            SPR: spr1249(aldB)
            CAC: CAC2967
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.5
            ExPASy - ENZYME nomenclature database: 4.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.5
            BRENDA, the Enzyme Database: 4.1.1.5
///
ENTRY       EC 4.1.1.6
NAME        Aconitate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     cis-Aconitate carboxy-lyase
REACTION    cis-Aconitate = Itaconate + CO2
SUBSTRATE   cis-Aconitate
PRODUCT     Itaconate
            CO2
COMMENT     cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-
            -1,2,3-tricarboxylate. Itaconic acid is a trivial name for
            2-methylenesuccinic acid.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.6
            ExPASy - ENZYME nomenclature database: 4.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.6
            BRENDA, the Enzyme Database: 4.1.1.6
///
ENTRY       EC 4.1.1.7
NAME        Benzoylformate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Benzoylformate carboxy-lyase
REACTION    Benzoylformate = Benzaldehyde + CO2
SUBSTRATE   Benzoylformate
PRODUCT     Benzaldehyde
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       PAE: PA4901(mdlC)
            TAC: Ta0500 Ta0780
            TVO: TVG0799969 TVG1255890
            SSO: SSO1647(mdlC)
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
STRUCTURES  PDB: 1BFD  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.7
            ExPASy - ENZYME nomenclature database: 4.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.7
            BRENDA, the Enzyme Database: 4.1.1.7
            SCOP (Structural Classification of Proteins): 4.1.1.7
///
ENTRY       EC 4.1.1.8
NAME        Oxalyl-CoA decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Oxalyl-CoA carboxy-lyase
REACTION    Oxalyl-CoA = Formyl-CoA + CO2
SUBSTRATE   Oxalyl-CoA
PRODUCT     Formyl-CoA
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b2373
            ECE: Z3637
            ECS: ECs3253
            MTU: Rv0118c
            MTC: MT0126
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.8
            ExPASy - ENZYME nomenclature database: 4.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.8
            BRENDA, the Enzyme Database: 4.1.1.8
///
ENTRY       EC 4.1.1.9
NAME        Malonyl-CoA decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Malonyl-CoA carboxy-lyase
REACTION    Malonyl-CoA = Acetyl-CoA + CO2
SUBSTRATE   Malonyl-CoA
            Acetyl-CoA
            Malonate
PRODUCT     Acetyl-CoA
            CO2
            Acetate
            Malonyl-CoA
COMMENT     Specific for malonyl-CoA. The enzyme from Pseudomonas ovalis
            also catalyses the reaction of EC 2.8.3.3.
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       ATH: At4g04320(T19B17.4)
            CEL: F35G12.1
            HSA: 23417(MLYCD)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.9
            ExPASy - ENZYME nomenclature database: 4.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.9
            BRENDA, the Enzyme Database: 4.1.1.9
///
ENTRY       EC 4.1.1.10
NAME        Deleted entry
            Aminomalonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
COMMENT     Deleted entry. Now included with EC 4.1.1.12.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.10
            ExPASy - ENZYME nomenclature database: 4.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.10
///
ENTRY       EC 4.1.1.11
NAME        Aspartate 1-decarboxylase
            Aspartate alpha-decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Aspartate 1-carboxy-lyase
REACTION    L-Aspartate = beta-Alanine + CO2
SUBSTRATE   L-Aspartate
PRODUCT     beta-Alanine
            CO2
COMMENT     The E. coli enzyme contains a pyruvoyl group.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00410  beta-Alanine metabolism
GENES       ECO: b0131(panD)
            ECE: Z0142(panD)
            ECS: ECs0135
            YPE: YPO3403(panD)
            XFA: XF0231
            PAE: PA4731
            NME: NMB1282
            NMA: NMA1492(panD)
            HPY: HP0034(panD)
            HPJ: jhp0030
            CJE: Cj0296c(panD)
            MLO: mll5826 mll9093
            CCR: CC2295
            BSU: BG11493(panD)
            BHA: BH1689(panD)
            SAU: SA2390(panD)
            SAV: SAV2581(panD)
            CAC: CAC2916(panD)
            MTU: Rv3601c(panD)
            MTC: MT3706.1
            MLE: ML0231(panD)
            SYN: sll0892(panD)
            DRA: DR0718
            AAE: aq_476(panD)
            TMA: TM0939
STRUCTURES  PDB: 1AW8  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.11
            ExPASy - ENZYME nomenclature database: 4.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.11
            BRENDA, the Enzyme Database: 4.1.1.11
            SCOP (Structural Classification of Proteins): 4.1.1.11
///
ENTRY       EC 4.1.1.12
NAME        Aspartate 4-decarboxylase
            Desulfinase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Aspartate 4-carboxy-lyase
REACTION    L-Aspartate = L-Alanine + CO2
SUBSTRATE   L-Aspartate
            Aminomalonate
            3-Sulfino-L-alanine
PRODUCT     L-Alanine
            CO2
            Glycine
            Sulfite
            L-Alanine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses the decarboxylation
            of aminomalonate (formerly listed as EC 4.1.1.10) and the
            desulfination of 3-sulfino-L-alanine to sulfite and alanine.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00272  Cysteine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.12
            ExPASy - ENZYME nomenclature database: 4.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.12
            BRENDA, the Enzyme Database: 4.1.1.12
///
ENTRY       EC 4.1.1.13
NAME        Deleted entry
            Carbamoylaspartate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.13
            ExPASy - ENZYME nomenclature database: 4.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.13
///
ENTRY       EC 4.1.1.14
NAME        Valine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Valine carboxy-lyase
REACTION    L-Valine = 2-Methylpropanamine + CO2
SUBSTRATE   L-Valine
            L-Leucine
PRODUCT     2-Methylpropanamine
            CO2
            3-Methylbutanamine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on L-leucine.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.14
            ExPASy - ENZYME nomenclature database: 4.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.14
            BRENDA, the Enzyme Database: 4.1.1.14
///
ENTRY       EC 4.1.1.15
NAME        Glutamate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Glutamate 1-carboxy-lyase
REACTION    L-Glutamate = 4-Aminobutanoate + CO2
SUBSTRATE   L-Glutamate
            L-Cysteate
            3-Sulfino-L-alanine
            L-Aspartate
PRODUCT     4-Aminobutanoate
            CO2
            Taurine
            Hypotaurine
            3-Aminopropanoate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The brain enzyme also acts on
            L-cysteate, 3-sulfino-L-alanine  and L-aspartate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00430  Taurine and hypotaurine metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1493(gadB) b3517(gadA)
            ECE: Z2215(gadB) Z4930(gadA)
            ECS: ECs2098
            VCH: VC1149
            LLA: L123581(gadB)
            MTU: Rv3432c(gadB)
            MTC: MT3538
            SYN: sll1641(gad)
            MJA: MJ0050
            MTH: MTH1116
            AFU: AF1323 AF2004 AF2295
            HAL: VNG0327G(gadD)
            PHO: PH0937
            PAB: PAB1578
            APE: APE0020 APE0412 APE2267
            SCE: YMR250W(GAD1)
            ATH: At2g02010(F14H20.8)
            CEL: B0222.4
            DME: CG14994(Gad1) CG5618 CG7811
            MMU: 95632(Gad1) 95634(Gad2)
            HSA: 2571(GAD1) 2572(GAD2) 2573(GAD3)
DISEASE     MIM: 138275  Glutamate decarboxylase-2, pancreas
            MIM: 266100  Glutamate decarboxylase-1, brain, 67kD
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWGH]-[LIVMFYWG]-x(3)-
                         [LIVMFYW]-x-[CA]-x(2)-[LIVMFYWQ]-x(2)-[RK]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.15
            ExPASy - ENZYME nomenclature database: 4.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.15
            BRENDA, the Enzyme Database: 4.1.1.15
///
ENTRY       EC 4.1.1.16
NAME        Hydroxyglutamate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Hydroxy-L-glutamate 1-carboxy-lyase
REACTION    3-Hydroxy-L-glutamate = 4-Amino-3-hydroxybutanoate + CO2
SUBSTRATE   3-Hydroxy-L-glutamate
PRODUCT     4-Amino-3-hydroxybutanoate
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.16
            ExPASy - ENZYME nomenclature database: 4.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.16
            BRENDA, the Enzyme Database: 4.1.1.16
///
ENTRY       EC 4.1.1.17
NAME        Ornithine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Ornithine carboxy-lyase
REACTION    L-Ornithine = Putrescine + CO2
SUBSTRATE   L-Ornithine
PRODUCT     Putrescine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00960  Alkaloid biosynthesis II
GENES       ECO: b0693(speF) b2965(speC)
            ECE: Z0839(speF) Z4310(speC)
            ECS: ECs0721 ECs3841
            YPE: YPO0960(speC)
            HIN: HI0591(speF)
            PMU: PM0806(speF)
            VCH: VCA1063
            PAE: PA4519
            MLO: mll2974
            SME: SMa0680 SMa0682
            CCR: CC0360
            AAE: aq_728(speC)
            TMA: TM1873
            SCE: YKL184W(SPE1)
            SPO: SPE1(spe1)
            CEL: odc-1
            DME: CG8719(Odc2) CG8721(Odc1)
            MMU: 1098220(Daq7) 97402(Odc)
            HSA: 4953(ODC1)
DISEASE     MIM: 165640  Ornithine decarboxylase-1
MOTIF       PS: PS00703  [STAV]-x-S-x-H-K-x(2)-[GSTAN](2)-x-[STA]-Q-[STA](2)
            PS: PS00878  [FY]-[PA]-x-K-[SACV]-[NHCLFW]-x(4)-[LIVMF]-[LIVMTA]-
                         x(2)-[LIVMA]-x(3)-[GTE]
            PS: PS00879  [GSA]-x(2,6)-[LIVMSCP]-x(2)-[LIVMF]-[DNS]-[LIVMCA]-G-G-
                         G-[LIVMFY]-[GSTPCEQ]
STRUCTURES  PDB: 1D7K  1F3T  1ORD  1C4K  2TOD  7ODC  1QU4  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.17
            ExPASy - ENZYME nomenclature database: 4.1.1.17
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.17
            BRENDA, the Enzyme Database: 4.1.1.17
            SCOP (Structural Classification of Proteins): 4.1.1.17
///
ENTRY       EC 4.1.1.18
NAME        Lysine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Lysine carboxy-lyase
REACTION    L-Lysine = Cadaverine + CO2
SUBSTRATE   L-Lysine
            5-Hydroxy-L-lysine
PRODUCT     Cadaverine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
            Also acts on 5-hydroxy-L-lysine.
PATHWAY     PATH: MAP00310  Lysine degradation
            PATH: MAP00960  Alkaloid biosynthesis II
GENES       ECO: b0186(ldcC) b4131(cadA)
            ECE: Z0198(ldcC) Z5734(cadA)
            ECS: ECs0188 ECs5113
            VCH: VC0281
            BHA: BH2640(cad)
            SPN: SP0916
            SPR: spr0816(cad)
            CAC: CAC2338
            SYN: sll1683(cad)
            DRA: DR1426
MOTIF       PS: PS00703  [STAV]-x-S-x-H-K-x(2)-[GSTAN](2)-x-[STA]-Q-[STA](2)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.18
            ExPASy - ENZYME nomenclature database: 4.1.1.18
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.18
            BRENDA, the Enzyme Database: 4.1.1.18
///
ENTRY       EC 4.1.1.19
NAME        Arginine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Arginine carboxy-lyase
REACTION    L-Arginine = Agmatine + CO2
SUBSTRATE   L-Arginine
PRODUCT     Agmatine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b2938(speA) b4117(adi)
            ECE: Z4283(speA) Z5719(adiA)
            ECS: ECs3814 ECs5099
            YPE: YPO0929(speA)
            PMU: PM1382(speA)
            XFA: XF0144
            VCH: VCA0815
            PAE: PA1818 PA4839(speA)
            NME: NMB0468
            NMA: NMA2017(speA)
            HPY: HP0422(speA)
            HPJ: jhp0962
            CJE: Cj0764c(speA)
            SME: SMa0680 SMa0682
            BSU: BG10212(speA)
            MTU: Rv2531c
            MTC: MT2607
            MLE: ML0524(adi)
            SYN: slr0662(speA) slr1312(speA)
            DRA: DR0243
MOTIF       PS: PS00703  [STAV]-x-S-x-H-K-x(2)-[GSTAN](2)-x-[STA]-Q-[STA](2)
            PS: PS00878  [FY]-[PA]-x-K-[SACV]-[NHCLFW]-x(4)-[LIVMF]-[LIVMTA]-
                         x(2)-[LIVMA]-x(3)-[GTE]
            PS: PS00879  [GSA]-x(2,6)-[LIVMSCP]-x(2)-[LIVMF]-[DNS]-[LIVMCA]-G-G-
                         G-[LIVMFY]-[GSTPCEQ]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.19
            ExPASy - ENZYME nomenclature database: 4.1.1.19
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.19
            BRENDA, the Enzyme Database: 4.1.1.19
///
ENTRY       EC 4.1.1.20
NAME        Diaminopimelate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     meso-2,6-Diaminoheptanedioate carboxy-lyase
REACTION    meso-2,6-Diaminoheptanedioate = L-Lysine + CO2
SUBSTRATE   meso-2,6-Diaminoheptanedioate
PRODUCT     L-Lysine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b2838(lysA)
            ECE: Z4156(lysA)
            ECS: ECs3695
            YPE: YPO0796(lysA)
            HIN: HI0727(lysA)
            PMU: PM1424(lysA)
            XFA: XF1116
            VCH: VC0125
            PAE: PA5277(lysA)
            BUC: BU438(lysA)
            NME: NMB1976
            NMA: NMA0468(lysA)
            HPY: HP0290(lysA)
            HPJ: jhp0275
            CJE: Cj0314(lysA)
            MLO: mlr3508
            SME: SMc00723(lysA)
            CCR: CC2213
            BSU: BG10510(lysA)
            BHA: BH1544
            SAU: SA0119 SA1232(lysA)
            SAV: SAV0117 SAV1385(lysA)
            LLA: L0121(lysA)
            SPN: SP1978
            SPR: spr1792(lysA)
            CAC: CAC0608(lisA)
            MTU: Rv1293(lysA)
            MTC: MT1332
            MLE: ML1128(lysA)
            SYN: sll0504(lysA)
            DRA: DR1758
            AAE: aq_1208(lysA)
            TMA: TM1517
            MJA: MJ1097(lysA)
            MTH: MTH1335
            AFU: AF0800(lysA)
            TAC: Ta0788
            TVO: TVG0827631
MOTIF       PS: PS00878  [FY]-[PA]-x-K-[SACV]-[NHCLFW]-x(4)-[LIVMF]-[LIVMTA]-
                         x(2)-[LIVMA]-x(3)-[GTE]
            PS: PS00879  [GSA]-x(2,6)-[LIVMSCP]-x(2)-[LIVMF]-[DNS]-[LIVMCA]-G-G-
                         G-[LIVMFY]-[GSTPCEQ]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.20
            ExPASy - ENZYME nomenclature database: 4.1.1.20
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.20
            BRENDA, the Enzyme Database: 4.1.1.20
///
ENTRY       EC 4.1.1.21
NAME        Phosphoribosylaminoimidazole carboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase
REACTION    1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate =
            1-(5-Phospho-D-ribosyl)-5-aminoimidazole + CO2
SUBSTRATE   1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
PRODUCT     1-(5-Phospho-D-ribosyl)-5-aminoimidazole
            CO2
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b0522(purK) b0523(purE)
            ECE: Z0677(purK) Z0678(purE)
            ECS: ECs0584 ECs0585
            YPE: YPO3076(purE) YPO3077(purK)
            HIN: HI1615(purE) HI1616(purK)
            PMU: PM0619(purE) PM0620(purK)
            XFA: XF2671 XF2672
            VCH: VC0051 VC0052
            PAE: PA5425(purK) PA5426(purE)
            NME: NMB1019 NMB1439
            NMA: NMA1245(purK) NMA1651(purE)
            CJE: Cj0702(purE)
            MLO: mlr3809 mlr3811
            SME: SMc04001(purE) SMc04002(purK)
            CCR: CC3283 CC3284
            BSU: BG10700(purE) BG10701(purK)
            BHA: BH0623(purE) BH0624(purK)
            SAU: SA0916 SA0917(purK)
            SAV: SAV1050(purE) SAV1051(purK)
            LLA: L151330(purK) L152487(purE)
            SPY: SPy0033(purE) SPy0034(purK)
            SPN: SP0053 SP0054
            SPR: spr0053(purE) spr0054(purK)
            CAC: CAC1390(purE)
            MTU: Rv3275c(purE) Rv3276c(purK)
            MTC: MT3375 MT3376
            MLE: ML0735(purK) ML0736(purE)
            SYN: sll0578(purK) sll0901(purE)
            DRA: DR0023 DR0024
            AAE: aq_1178(purE) aq_245(purK)
            TMA: TM0446 TM0447
            MJA: MJ0616(purE)
            MTH: MTH1393(purE)
            AFU: AF1271(purE)
            HAL: VNG0632G(purK) VNG0633G(purE)
            TAC: Ta0303 Ta1107
            TVO: TVG0442698 TVG1359744
            PHO: PH0320
            PAB: PAB1077(purE)
            SSO: SSO1064(purE) SSO1065(purK)
            STO: ST0806 ST0807
            SCE: YOR128C(ADE2)
            SPO: ADE6(ade6)
            CEL: B0286.3
            DME: CG17024
            HSA: 10606(ADE2H1)
MOTIF       PS: PS01057  [LIVMR]-[LIVFY]-P-[LIVM]-E-x-[IV]-[LVCAT]-R-x(3)-[TA]-
                         G-S
            PS: PS01058  [LI]-[IVCAP]-D-x-K-[LIFY]-E-[FI]-G
STRUCTURES  PDB: 1B6S  1D7A  1QCZ  1B6R  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.21
            ExPASy - ENZYME nomenclature database: 4.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.21
            BRENDA, the Enzyme Database: 4.1.1.21
            SCOP (Structural Classification of Proteins): 4.1.1.21
///
ENTRY       EC 4.1.1.22
NAME        Histidine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Histidine carboxy-lyase
REACTION    L-Histidine = Histamine + CO2
SUBSTRATE   L-Histidine
PRODUCT     Histamine
            CO2
COFACTOR    Pyridoxal phosphate
            Pyruvate
COMMENT     A pyridoxal-phosphate protein (in aminal tissues). The bacterial
            enzyme has a pyruvoyl residue as prosthetic group.
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       DME: CG3454(Hdc)
            MMU: 96062(Hdc) 96066(Hdc-s)
            HSA: 3067(HDC)
DISEASE     MIM: 142704  Histidine decarboxylase
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWGH]-[LIVMFYWG]-x(3)-
                         [LIVMFYW]-x-[CA]-x(2)-[LIVMFYWQ]-x(2)-[RK]
STRUCTURES  PDB: 1PYA  1HQ6  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.22
            ExPASy - ENZYME nomenclature database: 4.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.22
            BRENDA, the Enzyme Database: 4.1.1.22
            SCOP (Structural Classification of Proteins): 4.1.1.22
///
ENTRY       EC 4.1.1.23
NAME        Orotidine-5'-phosphate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Orotidine-5'-phosphate carboxy-lyase
REACTION    Orotidine 5'-phosphate = UMP + CO2
SUBSTRATE   Orotidine 5'-phosphate
PRODUCT     UMP
            CO2
COMMENT     The enzyme from higher eucaryotes is identical with EC 2.4.2.10.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b1281(pyrF)
            ECE: Z2525(pyrF)
            ECS: ECs1854
            YPE: YPO2227(pyrF)
            HIN: HI1224(pyrF)
            PMU: PM0797(pyrF)
            XFA: XF0034
            VCH: VC1911
            PAE: PA2876(pyrF)
            BUC: BU270(pyrF)
            NME: NMB0824
            NMA: NMA1033(pyrF)
            HPY: HP0005(pyrF)
            HPJ: jhp0005
            CJE: Cj0381c(pyrF)
            MLO: mll4751
            SME: SMc00412(pyrF)
            CCR: CC0105
            BSU: BG10719(pyrF)
            BHA: BH2533(pyrF)
            SAU: SA1047(pyrF)
            SAV: SAV1191(pyrF)
            LLA: L181692(pyrF)
            SPY: SPy0900(pyrF)
            SPN: SP0701
            SPR: spr0613(pyrF)
            CAC: CAC2652(pyrF)
            MTU: Rv1385(pyrF)
            MTC: MT1429
            MLE: ML0537(pyrF)
            SYN: sll0838(pyrF)
            DRA: DR2200
            AAE: aq_1580(pyrF)
            TMA: TM0332
            MJA: MJ0252
            MTH: MTH129
            AFU: AF0929
            HAL: VNG1673G(pyrF)
            TAC: Ta0073
            TVO: TVG0029151
            PHO: PH0731
            PAB: PAB1505
            APE: APE2348
            SSO: SSO0616(pyrF)
            SCE: YEL021W(URA3)
            SPO: URA4(ura4)
            CEL: T07C4.1
            DME: CG3593(r-l)
            HSA: 7372(UMPS)
DISEASE     MIM: 258900  Uridine monophosphate synthetase (orotate
                         phosphoribosyl transferase
MOTIF       PS: PS00103  [LIVMFYWCTA]-[LIVM]-[LIVMA]-[LIVMFC]-[DE]-D-[LIVMS]-
                         [LIVM]-[STAVD]-[STAR]-[GAC]-x-[STAR]
            PS: PS00156  [LIVMFTA]-[LIVMF]-x-D-x-K-x(2)-D-I-[GP]-x-T-[LIVMTA]
STRUCTURES  PDB: 1DBT  1DQW  1DQX  1DV7  1DVJ  1EIX  1JJK  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.23
            ExPASy - ENZYME nomenclature database: 4.1.1.23
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.23
            BRENDA, the Enzyme Database: 4.1.1.23
            SCOP (Structural Classification of Proteins): 4.1.1.23
///
ENTRY       EC 4.1.1.24
NAME        Aminobenzoate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Aminobenzoate carboxy-lyase
REACTION    4-Aminobenzoate or 2-Aminobenzoate = Aniline + CO2
SUBSTRATE   4-Aminobenzoate
            2-Aminobenzoate
PRODUCT     Aniline
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.24
            ExPASy - ENZYME nomenclature database: 4.1.1.24
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.24
            BRENDA, the Enzyme Database: 4.1.1.24
///
ENTRY       EC 4.1.1.25
NAME        Tyrosine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Tyrosine carboxy-lyase
REACTION    L-Tyrosine = Tyramine + CO2
SUBSTRATE   L-Tyrosine
PRODUCT     Tyramine
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The bacterial enzyme also acts on
            3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00950  Alkaloid biosynthesis I
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWGH]-[LIVMFYWG]-x(3)-
                         [LIVMFYW]-x-[CA]-x(2)-[LIVMFYWQ]-x(2)-[RK]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.25
            ExPASy - ENZYME nomenclature database: 4.1.1.25
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.25
            BRENDA, the Enzyme Database: 4.1.1.25
///
ENTRY       EC 4.1.1.26
NAME        Deleted entry
            DOPA decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
COMMENT     Deleted entry. Now included with EC 4.1.1.28.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.26
            ExPASy - ENZYME nomenclature database: 4.1.1.26
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.26
///
ENTRY       EC 4.1.1.27
NAME        Deleted entry
            Tryptophan decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
COMMENT     Deleted entry. Now included with EC 4.1.1.28.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.27
            ExPASy - ENZYME nomenclature database: 4.1.1.27
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.27
///
ENTRY       EC 4.1.1.28
NAME        Aromatic-L-amino-acid decarboxylase
            Dopa decarboxylase
            Tryptophan decarboxylase
            Hydroxytryptophan decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Aromatic-L-amino-acid decarboxy-lyase
REACTION    L-Tryptophan = Tryptamine + CO2
SUBSTRATE   L-Tryptophan
            5-Hydroxy-L-tryptophan
            Dihydroxy-L-phenylalanine
PRODUCT     Tryptamine
            CO2
COFACTOR    Pyridoxal phosphate
            Pyrroloquinoline quinone
COMMENT     A pyridoxal-phosphate protein. The enzyme acts on L-tryptophan,
            5-hydroxy-L-tryptophan and dihydroxy-L-phenylalanine.
            PQQ: Groen,B.W., van der Meer,R.A., Duine,J.A. FEBS Lett. 1988.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00950  Alkaloid biosynthesis I
GENES       MLO: mll0712
            CEL: F12A10.3 K01C8.3
            DME: CG10501(amd) CG10697(Ddc) CG10697_1(Ddc)
            MMU: 94876(Ddc)
            HSA: 1644(DDC)
DISEASE     MIM: 107930  DOPA decarboxylase (aromatic L-amino acid
                         decarboxylase)
MOTIF       PS: PS00392  S-[LIVMFYW]-x(5)-K-[LIVMFYWGH]-[LIVMFYWG]-x(3)-
                         [LIVMFYW]-x-[CA]-x(2)-[LIVMFYWQ]-x(2)-[RK]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.28
            ExPASy - ENZYME nomenclature database: 4.1.1.28
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.28
            BRENDA, the Enzyme Database: 4.1.1.28
///
ENTRY       EC 4.1.1.29
NAME        Sulfoalanine decarboxylase
            Cysteine-sulfinate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Sulfino-L-alanine carboxy-lyase
REACTION    3-Sulfino-L-alanine = Hypotaurine + CO2
SUBSTRATE   3-Sulfino-L-alanine
            L-Cysteate
PRODUCT     Hypotaurine
            CO2
            Taurine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on L-cysteate.
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.29
            ExPASy - ENZYME nomenclature database: 4.1.1.29
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.29
            BRENDA, the Enzyme Database: 4.1.1.29
///
ENTRY       EC 4.1.1.30
NAME        Pantothenoylcysteine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase
REACTION    N-((R)-Pantothenoyl)-L-cysteine = Pantetheine + CO2
SUBSTRATE   N-((R)-Pantothenoyl)-L-cysteine
PRODUCT     Pantetheine
            CO2
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.30
            ExPASy - ENZYME nomenclature database: 4.1.1.30
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.30
            BRENDA, the Enzyme Database: 4.1.1.30
///
ENTRY       EC 4.1.1.31
NAME        Phosphoenolpyruvate carboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Orthophosphate:oxaloacetate carboxyl-lyase (phosphorylating)
REACTION    Orthophosphate + Oxaloacetate = H2O + Phosphoenolpyruvate + CO2
SUBSTRATE   Orthophosphate
            Oxaloacetate
PRODUCT     H2O
            Phosphoenolpyruvate
            CO2
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b3956(ppc)
            ECE: Z5514(ppc)
            ECS: ECs4885
            YPE: YPO3929(ppc)
            HIN: HI1636(ppc)
            PMU: PM0546(ppc)
            VCH: VC2646
            PAE: PA3687(ppc)
            NME: NMB2061
            NMA: NMA0374(ppc)
            CCR: CC1493
            SPY: SPy0608(ppc)
            SPN: SP1068
            SPR: spr0974(ppc)
            MLE: ML0578(ppc)
            SYN: sll0920(ppc)
            DRA: DR1283
MOTIF       PS: PS00393  [IV]-M-[LIVM]-G-Y-S-D-S-x-K-D-[STAG]-G
            PS: PS00781  [VT]-x-T-A-H-P-T-[EQ]-x(2)-R-[KRH]
STRUCTURES  PDB: 1FIY  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.31
            ExPASy - ENZYME nomenclature database: 4.1.1.31
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.31
            BRENDA, the Enzyme Database: 4.1.1.31
            SCOP (Structural Classification of Proteins): 4.1.1.31
///
ENTRY       EC 4.1.1.32
NAME        Phosphoenolpyruvate carboxykinase (GTP)
            Phosphoenolpyruvate carboxylase
            Phosphopyruvate carboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     GTP:oxaloacetate carboxy-lyase (transphosphorylating)
REACTION    GTP + Oxaloacetate = GDP + Phosphoenolpyruvate + CO2;
            ITP + Oxaloacetate = IDP + Phosphoenolpyruvate + CO2
SUBSTRATE   GTP
            Oxaloacetate
            ITP
PRODUCT     GDP
            Phosphoenolpyruvate
            CO2
COMMENT     ITP can act as phosphate donor.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00620  Pyruvate metabolism
GENES       MTU: Rv0211(pckA)
            MTC: MT0221
            MLE: ML2624(pckA)
            CTR: CT710
            CPN: CPn0851
            CPA: CP1018
            CPJ: pckA
            TPA: TP0122(pckA)
            TAC: Ta0123
            TVO: TVG0204657
            PHO: PH0312
            PAB: PAB1253
            SSO: SSO2537
            STO: ST1058
            CEL: R11A5.4 W05G11.6
            DME: CG10924 CG17725(Pepck)
            MMU: 97501(Pck1)
            HSA: 5105(PCK1) 5106(PCK2)
DISEASE     MIM: 261680  Phosphoenolpyruvate carboxykinase-1 (soluble)
MOTIF       PS: PS00505  F-P-S-A-C-G-K-T-N
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.32
            ExPASy - ENZYME nomenclature database: 4.1.1.32
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.32
            BRENDA, the Enzyme Database: 4.1.1.32
///
ENTRY       EC 4.1.1.33
NAME        Diphosphomevalonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)
REACTION    ATP + (R)-5-Diphosphomevalonate = ADP + Orthophosphate +
            Isopentenyl diphosphate + CO2
SUBSTRATE   ATP
            (R)-5-Diphosphomevalonate
PRODUCT     ADP
            Orthophosphate
            Isopentenyl diphosphate
            CO2
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       SAU: SA0548(mvaD)
            SAV: SAV0580
            LLA: L9089(yeaH)
            SPY: SPy0877(mvaD)
            SPN: SP0382
            SPR: spr0339(mvd1)
            BBU: BB0686
            HAL: VNG0593G(dmd)
            SSO: SSO2989
            STO: ST0977
            SCE: YNR043W(MVD1)
            SPO: SPAC24C9.03(spac24c9.03)
            ATH: At2g38700(T6A23.10) At3g54250(F24B22.210)
            DME: CG8239
            HSA: 4597(MVD)
STRUCTURES  PDB: 1FI4  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.33
            ExPASy - ENZYME nomenclature database: 4.1.1.33
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.33
            BRENDA, the Enzyme Database: 4.1.1.33
///
ENTRY       EC 4.1.1.34
NAME        Dehydro-L-gulonate decarboxylase
            Keto-L-gulonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Dehydro-L-gulonate carboxy-lyase
REACTION    3-Dehydro-L-gulonate = L-Xylulose + CO2
SUBSTRATE   3-Dehydro-L-gulonate
PRODUCT     L-Xylulose
            CO2
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.34
            ExPASy - ENZYME nomenclature database: 4.1.1.34
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.34
            BRENDA, the Enzyme Database: 4.1.1.34
///
ENTRY       EC 4.1.1.35
NAME        UDPglucuronate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     UDP-D-glucuronate carboxy-lyase
REACTION    UDP-D-glucuronate = UDP-D-xylose + CO2
SUBSTRATE   UDP-D-glucuronate
PRODUCT     UDP-D-xylose
            CO2
COFACTOR    NAD+
COMMENT     Requires NAD+.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.35
            ExPASy - ENZYME nomenclature database: 4.1.1.35
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.35
            BRENDA, the Enzyme Database: 4.1.1.35
///
ENTRY       EC 4.1.1.36
NAME        Phosphopantothenoylcysteine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     N-((R)-4-Phosphopantothenoyl)-L-cysteine carboxy-lyase
REACTION    N-((R)-4-Phosphopantothenoyl)-L-cysteine =
            Pantetheine 4'-phosphate + CO2
SUBSTRATE   N-((R)-4-Phosphopantothenoyl)-L-cysteine
PRODUCT     Pantetheine 4'-phosphate
            CO2
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.36
            ExPASy - ENZYME nomenclature database: 4.1.1.36
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.36
            BRENDA, the Enzyme Database: 4.1.1.36
///
ENTRY       EC 4.1.1.37
NAME        Uroporphyrinogen decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Uroporphyrinogen-III carboxy-lyase
REACTION    Uroporphyrinogen III = Coproporphyrinogen + 4 CO2
SUBSTRATE   Uroporphyrinogen III
PRODUCT     Coproporphyrinogen
            CO2
COMMENT     Acts on a number of porphyrinogens.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b3997(hemE)
            ECE: Z5572(hemE)
            ECS: ECs4920
            YPE: YPO3734(hemE)
            PMU: PM1734(uroD)
            XFA: XF1332
            VCH: VC0332
            PAE: PA5034(hemE)
            NME: NMB0781
            NMA: NMA0991(hemE)
            HPY: HP0604(hemE)
            HPJ: jhp0551
            CJE: Cj1243(hemE)
            RPR: RP885(hemE)
            RCO: RC1374(hemE)
            MLO: mll4487
            SME: SMc02794(hemE)
            CCR: CC3763
            BSU: BG10429(hemE)
            BHA: BH1202(hemE)
            SAU: SA1652(hemE)
            SAV: SAV1818(hemE)
            MTU: Rv2678c(hemE)
            MTC: MT2752
            MLE: ML1043(hemE)
            CTR: CT747
            CMU: TC0123
            CPN: CPn0890
            CPA: CP0976
            CPJ: hemE
            SYN: slr0536(hemE)
            DRA: DR1133
            AAE: aq_334(dcuP)
            TAC: Ta0310
            TVO: TVG1357015
            SCE: YDR047W(HEM12)
            SPO: SPCC4B3.05C(spcc4b3.05c)
            ATH: At2g40490(T2P4.16)
            DME: CG1818(Updo)
            MMU: 98916(Urod)
            HSA: 7389(UROD)
DISEASE     MIM: 176100  Uroporphyrinogen decarboxylase
MOTIF       PS: PS00906  [SP]-[IVC]-W-[LIVMFYC]-[LM]-R-Q-[AV]-G-R
            PS: PS00907  [LIMF]-[GAV]-F-[STAGCV]-[STAGC]-x-P-[FW]-T-[LIV]-x(2)-
                         Y-x(2)-[ADE]-[GK]
            PS: PS01039  G-[FYIL]-[DE]-[LIVMT]-[DE]-[LIVMF]-x(3)-[LIVMA]-[VAGC]-
                         x(2)-[LIVMAGN]
STRUCTURES  PDB: 1URO  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.37
            ExPASy - ENZYME nomenclature database: 4.1.1.37
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.37
            BRENDA, the Enzyme Database: 4.1.1.37
            SCOP (Structural Classification of Proteins): 4.1.1.37
///
ENTRY       EC 4.1.1.38
NAME        Phosphoenolpyruvate carboxykinase (pyrophosphate)
            Phosphopyruvate carboxylase
            Phosphoenolpyruvate carboxylase
            PEP carboxyphosphotransferase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Pyrophosphate:oxaloacetate carboxy-lyase (transphosphorylating)
REACTION    Pyrophosphate + Oxaloacetate = Orthophosphate +
            Phosphoenolpyruvate + CO2
SUBSTRATE   Pyrophosphate
            Oxaloacetate
            Pyruvate
PRODUCT     Orthophosphate
            Phosphoenolpyruvate
            CO2
COMMENT     Also catalyses the reaction: phosphoenolpyruvate + orthophosphate
            = pyruvate + pyrophosphate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.38
            ExPASy - ENZYME nomenclature database: 4.1.1.38
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.38
            BRENDA, the Enzyme Database: 4.1.1.38
///
ENTRY       EC 4.1.1.39
NAME        Ribulose-bisphosphate carboxylase
            Ribulosebisphosphate carboxylase/oxygenase
            Rubisco
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Phospho-D-glycerate carboxy-lyase (dimerizing)
REACTION    D-Ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-Phospho-D-glycerate;
            D-Ribulose 1,5-bisphosphate + O2  = 3-Phospho-D-glycerate +
            2-Phosphoglycolate
SUBSTRATE   D-Ribulose 1,5-bisphosphate
            CO2
            H2O
            O2
PRODUCT     3-Phospho-D-glycerate
            2-Phosphoglycolate
COFACTOR    Copper
COMMENT     A copper proein. Will utilize O2 instead of CO2, forming
            3-phospho-D-glycerate and 2-phosphoglycolate.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00710  Carbon fixation
GENES       MLO: mll7006
            SME: SMb20197(cbbS) SMb20198(cbbL) SMb20393(rbcL)
            BSU: BG13282(ykrW)
            SYN: slr0009(rbcL) slr0012(rbcS)
            MJA: MJ1235(rbcL)
            AFU: AF1587(rbcL-1) AF1638(rbcL-2)
            PHO: PH0939
            PAB: PAB1580(rbcL)
            ATH: At1g67090(F1O19.14)
MOTIF       PS: PS00157  G-x-[DN]-F-x-K-x-D-E
STRUCTURES  PDB: 1AA1  1BUR  1BWV  1BXN  1EJ7  1RBA  1RBL  1RBO  1RCO  1RCX  
                 1AUS  1RLD  1RSC  1RUS  1RXO  2RUS  3RUB  4RUB  5RUB  8RUC  
                 9RUB  1RLC  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.39
            ExPASy - ENZYME nomenclature database: 4.1.1.39
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.39
            BRENDA, the Enzyme Database: 4.1.1.39
            SCOP (Structural Classification of Proteins): 4.1.1.39
///
ENTRY       EC 4.1.1.40
NAME        Hydroxypyruvate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Hydroxypyruvate carboxy-lyase
REACTION    Hydroxypyruvate = Glycolaldehyde + CO2
SUBSTRATE   Hydroxypyruvate
PRODUCT     Glycolaldehyde
            CO2
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.40
            ExPASy - ENZYME nomenclature database: 4.1.1.40
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.40
            BRENDA, the Enzyme Database: 4.1.1.40
///
ENTRY       EC 4.1.1.41
NAME        Methylmalonyl-CoA decarboxylase
            Propionyl-CoA carboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     (S)-2-Methyl-3-oxopropanoyl-CoA carboxy-lyase
REACTION    (S)-2-Methyl-3-oxopropanoyl-CoA = Propanoyl-CoA + CO2
SUBSTRATE   (S)-2-Methyl-3-oxopropanoyl-CoA
PRODUCT     Propanoyl-CoA
            CO2
COMMENT     The enzyme from Veillonella alcalescens is a biotinyl-protein,
            requires Na+ and acts as a sodium pump.
PATHWAY     PATH: MAP00640  Propanoate metabolism
GENES       BHA: BH2957(mmdA)
            SPY: SPy1176 SPy1177 SPy1183 SPy1184
            TMA: TM0716 TM0717
            AFU: AF2216(mmdC) AF2217(mmdA)
            HAL: VNG1529G(mmdA)
            PHO: PH1283 PH1284 PH1287
            PAB: PAB1769(mmdA) PAB1771 PAB1772
            SSO: SSO2463(ppcB)
            STO: ST0591
STRUCTURES  PDB: 1EF8  1EF9  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.41
            ExPASy - ENZYME nomenclature database: 4.1.1.41
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.41
            BRENDA, the Enzyme Database: 4.1.1.41
            SCOP (Structural Classification of Proteins): 4.1.1.41
///
ENTRY       EC 4.1.1.42
NAME        Carnitine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Carnitine carboxy-lyase
REACTION    Carnitine = 2-Methylcholine + CO2
SUBSTRATE   Carnitine
PRODUCT     2-Methylcholine
            CO2
COFACTOR    ATP
COMMENT     Requires ATP.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.42
            ExPASy - ENZYME nomenclature database: 4.1.1.42
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.42
            BRENDA, the Enzyme Database: 4.1.1.42
///
ENTRY       EC 4.1.1.43
NAME        Phenylpyruvate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Phenylpyruvate carboxy-lyase
REACTION    Phenylpyruvate = Phenylacetaldehyde + CO2
SUBSTRATE   Phenylpyruvate
            Indolepyruvate
PRODUCT     Phenylacetaldehyde
            CO2
            Indoleacetaldehyde
COMMENT     Also acts on indolepyruvate.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.43
            ExPASy - ENZYME nomenclature database: 4.1.1.43
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.43
            BRENDA, the Enzyme Database: 4.1.1.43
///
ENTRY       EC 4.1.1.44
NAME        4-Carboxymuconolactone decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     4-Carboxymuconolactone carboxy-lyase
REACTION    2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate =
            4,5-Dihydro-5-oxofuran-2-acetate + CO2
SUBSTRATE   2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
PRODUCT     4,5-Dihydro-5-oxofuran-2-acetate
            CO2
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       YPE: YPO1999 YPO3649
            PAE: PA0232(pcaC) PA4486
            MLO: mlr7207
            SME: SMb20578(pcaC)
            CCR: CC2411
            LLA: L35675(pcaC)
            DRA: DR0973 DR1204
            MTH: MTH234
            SSO: SSO2884(pcaC)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.44
            ExPASy - ENZYME nomenclature database: 4.1.1.44
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.44
            BRENDA, the Enzyme Database: 4.1.1.44
///
ENTRY       EC 4.1.1.45
NAME        Aminocarboxymuconate-semialdehyde decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2-Amino-3-(3-oxoprop-2-enyl)-but-2-enedioate carboxy-lyase
REACTION    2-Amino-3-(3-oxoprop-1-enyl)-but-2-enedioate =
            2-Aminomuconate semialdehyde + CO2
SUBSTRATE   2-Amino-3-(3-oxoprop-1-enyl)-but-2-enedioate
PRODUCT     2-Aminomuconate semialdehyde
            CO2
COMMENT     Product rearranges non-enzymically to picolinate.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.45
            ExPASy - ENZYME nomenclature database: 4.1.1.45
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.45
            BRENDA, the Enzyme Database: 4.1.1.45
///
ENTRY       EC 4.1.1.46
NAME        O-Pyrocatechuate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2,3-Dihydroxybenzoate carboxy-lyase
REACTION    2,3-Dihydroxybenzoate = Catechol + CO2
SUBSTRATE   2,3-Dihydroxybenzoate
PRODUCT     Catechol
            CO2
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00629  Carbazole degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.46
            ExPASy - ENZYME nomenclature database: 4.1.1.46
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.46
            BRENDA, the Enzyme Database: 4.1.1.46
///
ENTRY       EC 4.1.1.47
NAME        Tartronate-semialdehyde synthase
            Tartronate semialdehyde carboxylase
            Glyoxylate carbo-ligase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Glyoxylate carboxy-lyase (dimerizing)
REACTION    2 Glyoxylate = Tartronate semialdehyde + CO2
SUBSTRATE   Glyoxylate
PRODUCT     Tartronate semialdehyde
            CO2
COFACTOR    FAD
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b0507(gcl)
            ECE: Z0661(gcl)
            ECS: ECs0568
            PAE: PA1502(gcl)
            MLO: mlr0251
            SME: SMb20681(gcl)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.47
            ExPASy - ENZYME nomenclature database: 4.1.1.47
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.47
            BRENDA, the Enzyme Database: 4.1.1.47
///
ENTRY       EC 4.1.1.48
NAME        Indole-3-glycerol-phosphate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate
            carboxy-lyase(cyclizing)
REACTION    1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate =
            1-(Indol-3-yl)glycerol 3-phosphate + CO2 + H2O
SUBSTRATE   1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
PRODUCT     1-(Indol-3-yl)glycerol 3-phosphate
            CO2
            H2O
COFACTOR    Pyruvate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein together with one or more other components of the system
            for the biosynthesis of tryptophan (EC 2.4.2.18, 4.1.3.27,
            4.2.1.20, 5.3.1.24).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1262(trpC)
            ECE: Z2549(trpC)
            ECS: ECs1834
            YPE: YPO2205(trpC)
            HIN: HI1389.1(trpC)
            PMU: PM0580(trpC)
            XFA: XF0213
            VCH: VC1171
            PAE: PA0651(trpC)
            BUC: BU279(trpC)
            NME: NMB0275
            NMA: NMA2212(trpC)
            HPY: HP1279(trpC)
            HPJ: jhp1200
            CJE: Cj0498(trpC)
            MLO: mlr0615
            SME: SMc00236(trpC)
            CCR: CC1899
            BSU: BG11038(trpC)
            BHA: BH1661(trpC)
            SAU: SA1202(trpC)
            SAV: SAV1355(trpC)
            LLA: L0051(trpC)
            SPN: SP1814
            SPR: spr1634(trpC)
            CAC: CAC3160(trpC)
            MTU: Rv1611(trpC)
            MTC: MT1646
            MLE: ML1271(trpC)
            SYN: slr0546(trpC)
            DRA: DR1426
            AAE: aq_1787(trpC)
            TMA: TM0140
            MJA: MJ0918(trpC)
            MTH: MTH1657(trpC)
            AFU: AF1604(trpD)
            HAL: VNG0305G(trpC)
            TAC: Ta0808
            TVO: TVG1077942
            PAB: PAB2043
            APE: APE2546
            SSO: SSO0895(trpC)
            STO: ST1226
            SCE: YKL211C(TRP3)
            ATH: At2g04400(T1O3.19)
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00614  [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[STAHKR]-S-P-
                         [ST]-x(3)-[LIVMFYST]
STRUCTURES  PDB: 1A53  1JUK  1JUL  1PII  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.48
            ExPASy - ENZYME nomenclature database: 4.1.1.48
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.48
            BRENDA, the Enzyme Database: 4.1.1.48
            SCOP (Structural Classification of Proteins): 4.1.1.48
///
ENTRY       EC 4.1.1.49
NAME        Phosphoenolpyruvate carboxykinase (ATP)
            Phosphopyruvate carboxylase (ATP)
            Phosphoenolpyruvate carboxylase
            Phosphoenolpyruvate carboxykinase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     ATP:oxaloacetate carboxy-lyase (transphosphorylating)
REACTION    ATP + Oxaloacetate = ADP + Phosphoenolpyruvate + CO2
SUBSTRATE   ATP
            Oxaloacetate
PRODUCT     ADP
            Phosphoenolpyruvate
            CO2
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b3403(pckA)
            ECE: Z4758(pckA)
            ECS: ECs4245
            YPE: YPO0138(pckA)
            HIN: HI0809(pckA)
            PMU: PM1542(pckA)
            VCH: VC2738
            PAE: PA5192(pckA)
            CJE: Cj0932c(pckA)
            MLO: mlr5096
            SME: SMc02562(pckA)
            BSU: BG11841(pckA)
            BHA: BH3302(pckA)
            SAU: SA1609(pckA)
            SAV: SAV1777(pckA)
            DRA: DR0977
            SCE: YKR097W(PCK1)
MOTIF       PS: PS00532  L-I-G-D-D-E-H-x-W-x-[DE]-x-G-[IV]-x-N
STRUCTURES  PDB: 1AYL  1OEN  1AQ2  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.49
            ExPASy - ENZYME nomenclature database: 4.1.1.49
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.49
            BRENDA, the Enzyme Database: 4.1.1.49
            SCOP (Structural Classification of Proteins): 4.1.1.49
///
ENTRY       EC 4.1.1.50
NAME        Adenosylmethionine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     S-Adenosyl-L-methionine carboxy-lyase
REACTION    S-Adenosyl-L-methionine =
            (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
SUBSTRATE   S-Adenosyl-L-methionine
PRODUCT     (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
            CO2
COFACTOR    Pyruvate
COMMENT     The E. coli enzyme contains a pyruvoyl group.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b0120(speD)
            ECE: Z0130(speD)
            ECS: ECs0124
            YPE: YPO3412(speD)
            XFA: XF1539
            PAE: PA0654(speD)
            BUC: BU208(speD)
            BSU: BG13832(speD)
            BHA: BH3148
            CAC: CAC2601
            SCE: YOL052C(SPE2)
            CEL: F47G4.7
            DME: CG5029(SamDC)
            HSA: 262(AMD1) 263(AMDP1)
DISEASE     MIM: 180980  S-adenosylmethionine decarboxylase-1
MOTIF       PS: PS01336  [SA]-[FY]-[LIV]-L-[STN]-E-S-S-[LIVMF]-F-[LIV]
STRUCTURES  PDB: 1I79  1I7B  1I7C  1I7M  1JEN  1I72  1JL0  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.50
            ExPASy - ENZYME nomenclature database: 4.1.1.50
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.50
            BRENDA, the Enzyme Database: 4.1.1.50
            SCOP (Structural Classification of Proteins): 4.1.1.50
///
ENTRY       EC 4.1.1.51
NAME        3-Hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase
REACTION    3-Hydroxy-2-methylpyridine-4,5-dicarboxylate =
            3-Hydroxy-2-methylpyridine-5-carboxylate + CO2
SUBSTRATE   3-Hydroxy-2-methylpyridine-4,5-dicarboxylate
PRODUCT     3-Hydroxy-2-methylpyridine-5-carboxylate
            CO2
PATHWAY     PATH: MAP00750  Vitamin B6 metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.51
            ExPASy - ENZYME nomenclature database: 4.1.1.51
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.51
            BRENDA, the Enzyme Database: 4.1.1.51
///
ENTRY       EC 4.1.1.52
NAME        6-Methylsalicylate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     6-Methylsalicylate carboxy-lyase
REACTION    6-Methylsalicylate = 3-Cresol + CO2
SUBSTRATE   6-Methylsalicylate
PRODUCT     3-Cresol
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.52
            ExPASy - ENZYME nomenclature database: 4.1.1.52
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.52
            BRENDA, the Enzyme Database: 4.1.1.52
///
ENTRY       EC 4.1.1.53
NAME        Phenylalanine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Phenylalanine carboxy-lyase
REACTION    L-Phenylalanine = Phenethylamine + CO2
SUBSTRATE   L-Phenylalanine
            L-Tyrosine
            L-Tryptophan
PRODUCT     Phenethylamine
            CO2
            Tyramine
            Tryptamine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on tyrosine and other
            aromatic amino acids.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.53
            ExPASy - ENZYME nomenclature database: 4.1.1.53
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.53
            BRENDA, the Enzyme Database: 4.1.1.53
///
ENTRY       EC 4.1.1.54
NAME        Dihydroxyfumarate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Dihydroxyfumarate carboxy-lyase
REACTION    Dihydroxyfumarate = Tartronate semialdehyde + CO2
SUBSTRATE   Dihydroxyfumarate
PRODUCT     Tartronate semialdehyde
            CO2
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.54
            ExPASy - ENZYME nomenclature database: 4.1.1.54
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.54
            BRENDA, the Enzyme Database: 4.1.1.54
///
ENTRY       EC 4.1.1.55
NAME        4,5-Dihydroxyphthalate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     4,5-Dihydroxyphthalate carboxy-lyase
REACTION    4,5-Dihydroxyphthalate = 3,4-Dihydroxybenzoate + CO2
SUBSTRATE   4,5-Dihydroxyphthalate
PRODUCT     3,4-Dihydroxybenzoate
            CO2
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.55
            ExPASy - ENZYME nomenclature database: 4.1.1.55
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.55
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.55
            BRENDA, the Enzyme Database: 4.1.1.55
///
ENTRY       EC 4.1.1.56
NAME        3-Oxolaurate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3-Oxododecanoate carboxy-lyase
REACTION    3-Oxododecanoate = 2-Undecanone + CO2
SUBSTRATE   3-Oxododecanoate
PRODUCT     2-Undecanone
            CO2
COMMENT     Also decarboxylates other C14 to C16 oxo acids.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.56
            ExPASy - ENZYME nomenclature database: 4.1.1.56
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.56
            BRENDA, the Enzyme Database: 4.1.1.56
///
ENTRY       EC 4.1.1.57
NAME        Methionine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     L-Methionine carboxy-lyase
REACTION    L-Methionine = 3-Methylthiopropanamine + CO2
SUBSTRATE   L-Methionine
PRODUCT     3-Methylthiopropanamine
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.57
            ExPASy - ENZYME nomenclature database: 4.1.1.57
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.57
            BRENDA, the Enzyme Database: 4.1.1.57
///
ENTRY       EC 4.1.1.58
NAME        Orsellinate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Orsellinate carboxy-lyase
REACTION    2,4-Dihydroxy-6-methylbenzoate = Orcinol + CO2
SUBSTRATE   2,4-Dihydroxy-6-methylbenzoate
PRODUCT     Orcinol
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.58
            ExPASy - ENZYME nomenclature database: 4.1.1.58
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.58
            BRENDA, the Enzyme Database: 4.1.1.58
///
ENTRY       EC 4.1.1.59
NAME        Gallate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Gallate carboxy-lyase
REACTION    3,4,5-Trihydroxybenzoate = Pyrogallol + CO2
SUBSTRATE   3,4,5-Trihydroxybenzoate
PRODUCT     Pyrogallol
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.59
            ExPASy - ENZYME nomenclature database: 4.1.1.59
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.59
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.59
            BRENDA, the Enzyme Database: 4.1.1.59
///
ENTRY       EC 4.1.1.60
NAME        Stipitatonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Stipitatonate carboxy-lyase (decyclizing)
REACTION    Stipitatonate = Stipitatate + CO2
SUBSTRATE   Stipitatonate
PRODUCT     Stipitatate
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.60
            ExPASy - ENZYME nomenclature database: 4.1.1.60
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.60
            BRENDA, the Enzyme Database: 4.1.1.60
///
ENTRY       EC 4.1.1.61
NAME        4-Hydroxybenzoate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     4-Hydroxybenzoate carboxy-lyase
REACTION    4-Hydroxybenzoate = Phenol + CO2
SUBSTRATE   4-Hydroxybenzoate
PRODUCT     Phenol
            CO2
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.61
            ExPASy - ENZYME nomenclature database: 4.1.1.61
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.61
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.61
            BRENDA, the Enzyme Database: 4.1.1.61
///
ENTRY       EC 4.1.1.62
NAME        Gentisate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Gentisate carboxy-lyase
REACTION    2,5-Dihydroxybenzoate = Hydroquinone + CO2
SUBSTRATE   2,5-Dihydroxybenzoate
PRODUCT     Hydroquinone
            CO2
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.62
            ExPASy - ENZYME nomenclature database: 4.1.1.62
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.62
            BRENDA, the Enzyme Database: 4.1.1.62
///
ENTRY       EC 4.1.1.63
NAME        Protocatechuate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Protocatechuate carboxy-lyase
REACTION    3,4-Dihydroxybenzoate = Catechol + CO2
SUBSTRATE   3,4-Dihydroxybenzoate
PRODUCT     Catechol
            CO2
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.63
            ExPASy - ENZYME nomenclature database: 4.1.1.63
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.63
            BRENDA, the Enzyme Database: 4.1.1.63
///
ENTRY       EC 4.1.1.64
NAME        2,2-Dialkylglycine decarboxylase (pyruvate)
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2,2-Dialkylglycine carboxylyase(amino-transferring)
REACTION    2,2-Dialkylglycine + Pyruvate = Dialkyl ketone + CO2 + L-Alanine
SUBSTRATE   2,2-Dialkylglycine
            Pyruvate
            2-Amino-2-methylpropanoate
            2-Amino-2-methylbutanoate
            1-Aminocyclopentanecarboxylate
PRODUCT     Dialkyl ketone
            CO2
            L-Alanine
            Acetone
            Methyl ethyl ketone
            Cyclopentanone
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Acts on 2-amino-2-methylpropanoate
            (i.e. 2-methylalanine), 2-amino-2-methylbutanoate and
            1-aminocyclopentanecarboxylate.
GENES       SPO: SPAC1039.07C(spac1039.07c)
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
STRUCTURES  PDB: 1D7S  1D7U  1D7V  1DGD  1DGE  1DKA  2DKB  1D7R  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.64
            ExPASy - ENZYME nomenclature database: 4.1.1.64
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.64
            BRENDA, the Enzyme Database: 4.1.1.64
            SCOP (Structural Classification of Proteins): 4.1.1.64
///
ENTRY       EC 4.1.1.65
NAME        Phosphatidylserine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Phsophatidyl-L-serine carboxy-lyase
REACTION    Phosphatidyl-L-serine = Phosphatidylethanolamine + CO2
SUBSTRATE   Phosphatidyl-L-serine
PRODUCT     Phosphatidylethanolamine
            CO2
COFACTOR    Pyridoxal phosphate
            Pyruvate
COMMENT     A pyridoxal-phosphate protein. In E.coli the prosthetic group
            is a pyruvoyl group.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b4160(psd)
            ECE: Z5766
            ECS: ECs5139
            YPE: YPO0364(psd)
            HIN: HI0160(psd)
            PMU: PM1899(psd)
            XFA: XF1365
            VCH: VC0339
            PAE: PA4957(psd)
            HPY: HP1357(psd)
            HPJ: jhp1275
            CJE: Cj0847(psd)
            RPR: RP241
            RCO: RC0325(psd)
            MLO: mlr7821
            BSU: BG11013(psd)
            BHA: BH1311(psd)
            CAC: CAC0031(psdD) CAC0799(psd)
            MTU: Rv0437c(psd)
            MTC: MT0453
            MLE: ML0311
            CTR: CT699
            CMU: TC0072
            CPN: CPn0839
            CPA: CP1030
            CPJ: psdD
            MJA: MJ0817
            MTH: MTH1026
            AFU: AF2045(psd2)
            HAL: VNG2255C
            SCE: YGR170W(PSD2) YNL169C(PSD1)
            SPO: SPAC25B8.03(spac25b8.03) SPBC16E9.18
            CEL: B0361.5
            HSA: 23761(PISD)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.65
            ExPASy - ENZYME nomenclature database: 4.1.1.65
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.65
            BRENDA, the Enzyme Database: 4.1.1.65
///
ENTRY       EC 4.1.1.66
NAME        Uracil-5-carboxylate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Uracil-5-carboxylate carboxy-lyase
REACTION    Uracil 5-carboxylate = Uracil + CO2
SUBSTRATE   Uracil 5-carboxylate
PRODUCT     Uracil
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.66
            ExPASy - ENZYME nomenclature database: 4.1.1.66
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.66
            BRENDA, the Enzyme Database: 4.1.1.66
///
ENTRY       EC 4.1.1.67
NAME        UDPgalacturonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     UDP-D-galacturonate carboxy-lyase
REACTION    UDP-D-galacturonate = UDP-L-arabinose + CO2
SUBSTRATE   UDP-D-galacturonate
PRODUCT     UDP-L-arabinose
            CO2
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.67
            ExPASy - ENZYME nomenclature database: 4.1.1.67
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.67
            BRENDA, the Enzyme Database: 4.1.1.67
///
ENTRY       EC 4.1.1.68
NAME        5-Oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     5-Oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase
REACTION    5-Oxopent-3-ene-1,2,5-tricarboxylate = 2-Oxohept-3-enedioate + CO2
SUBSTRATE   5-Oxopent-3-ene-1,2,5-tricarboxylate
PRODUCT     2-Oxohept-3-enedioate
            CO2
PATHWAY     PATH: MAP00350  Tyrosine metabolism
GENES       PMU: PM1528(hpaG_1) PM1529(hpaG_2)
            PAE: PA4121 PA4122
            DRA: DRA0226
STRUCTURES  PDB: 1I7O  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.68
            ExPASy - ENZYME nomenclature database: 4.1.1.68
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.68
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.68
            BRENDA, the Enzyme Database: 4.1.1.68
///
ENTRY       EC 4.1.1.69
NAME        3,4-Dihydroxyphthalate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     3,4-Dihydroxyphthalate carboxy-lyase
REACTION    3,4-Dihydroxyphthalate = 3,4-Dihydroxybenzoate + CO2
SUBSTRATE   3,4-Dihydroxyphthalate
PRODUCT     3,4-Dihydroxybenzoate
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.69
            ExPASy - ENZYME nomenclature database: 4.1.1.69
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.69
            BRENDA, the Enzyme Database: 4.1.1.69
///
ENTRY       EC 4.1.1.70
NAME        Glutaconyl-CoA decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     Pent-2-enoyl-CoA carboxy-lyase
REACTION    Pent-2-enoyl-CoA = But-2-enoyl-CoA + CO2
SUBSTRATE   Pent-2-enoyl-CoA
PRODUCT     But-2-enoyl-CoA
            CO2
COMMENT     The enzyme from Acidaminococcus fermentans is a biotinyl-protein,
            requires Na+, and acts as a sodium pump.
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.70
            ExPASy - ENZYME nomenclature database: 4.1.1.70
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.70
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.1.70
            BRENDA, the Enzyme Database: 4.1.1.70
///
ENTRY       EC 4.1.1.71
NAME        2-Oxoglutarate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     2-Oxoglutarate carboxy-lyase
REACTION    2-Oxoglutarate = Succinate semialdehyde + CO2
SUBSTRATE   2-Oxoglutarate
PRODUCT     Succinate semialdehyde
            CO2
COFACTOR    Thiamine diphosphate
COMMENT     Requires thiamine diphosphate. Highly specific.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.71
            ExPASy - ENZYME nomenclature database: 4.1.1.71
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.71
            BRENDA, the Enzyme Database: 4.1.1.71
///
ENTRY       EC 4.1.1.72
NAME        Branched-chain-2-oxoacid decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     (3S)-3-Methyl-2-oxopentanoate carboxy-lyase
REACTION    (3S)-3-Methyl-2-oxopentanoate = 2-Methylbutanal + CO2
SUBSTRATE   (3S)-3-Methyl-2-oxopentanoate
PRODUCT     2-Methylbutanal
            CO2
COMMENT     Acts on a number of 2-oxo acids, with a high affinity towards
            branched-chain substrates. The aldehyde formed may be enzyme-
            bound, and may be an intermediate in the bacterial system for
            biosynthesis of branched-chain fatty acids.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.72
            ExPASy - ENZYME nomenclature database: 4.1.1.72
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.72
            BRENDA, the Enzyme Database: 4.1.1.72
///
ENTRY       EC 4.1.1.73
NAME        Tartrate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
SYSNAME     (R,R)-Tartrate carboxy-lyase
REACTION    (R,R)-Tartaric acid = D-Glycerate + CO2
SUBSTRATE   (R,R)-Tartaric acid
PRODUCT     D-Glycerate
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.73
            ExPASy - ENZYME nomenclature database: 4.1.1.73
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.73
            BRENDA, the Enzyme Database: 4.1.1.73
///
ENTRY       EC 4.1.1.74
NAME        Indole-3-pyruvate decarboxylase
            Indolepyruvate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
REACTION    Indole-3-pyruvate = Indole-3-acetaldehyde + CO2
SUBSTRATE   Indole-3-pyruvate
PRODUCT     Indole-3-acetaldehyde
            CO2
COMMENT     More specific than EC 4.1.1.1
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.74
            ExPASy - ENZYME nomenclature database: 4.1.1.74
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.74
///
ENTRY       EC 4.1.1.75
NAME        5-Guanidino-2-oxopentanoate decarboxylase
            2-Oxo-5-guanidinopentanoate decarboxylase
            2-Oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
REACTION    5-Guanidino-2-oxo-pentanoate = 4-Guanidinobutanoate + CO2
SUBSTRATE   5-Guanidino-2-oxo-pentanoate
PRODUCT     4-Guanidinobutanoate
            CO2
COFACTOR    Thiamin pyrophosphate
            Divalent cation
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.75
            ExPASy - ENZYME nomenclature database: 4.1.1.75
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.75
///
ENTRY       EC 4.1.1.76
NAME        Arylmalonate decarboxylase
            AMDase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
REACTION    2-Aryl-2-methylmalonate = 2-Arylpropionate + CO2
SUBSTRATE   2-Aryl-2-methylmalonate
PRODUCT     2-Arylpropionate
            CO2
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.76
            ExPASy - ENZYME nomenclature database: 4.1.1.76
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.76
///
ENTRY       EC 4.1.1.77
NAME        4-Oxalocrotonate decarboxylase
CLASS       Lyases
            Carbon-carbon lyases
            Carboxy-lyases
REACTION    4-Oxalocrotonate = 2-Oxopent-4-enoate + CO2
SUBSTRATE   4-Oxalocrotonate
PRODUCT     2-Oxopent-4-enoate
            CO2
COMMENT     Involved in the meta-cleavage pathway for the degradation of
            phenols, cresols and catechols.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00624  Xylene degradation
            PATH: MAP00628  Fluorene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.1.77
            ExPASy - ENZYME nomenclature database: 4.1.1.77
            WIT (What Is There) Metabolic Reconstruction: 4.1.1.77
///
ENTRY       EC 4.1.2.1
NAME        Deleted entry
            Hydroxyoxobutyrate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry. Now included with EC 4.1.3.16.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.1
            ExPASy - ENZYME nomenclature database: 4.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.1
///
ENTRY       EC 4.1.2.2
NAME        Ketotetrose-phosphate aldolase
            Phosphoketotetrose aldolase
            Erythrulose-1-phosphate synthetase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     Erythrulose-1-phosphate formaldehyde-lyase
REACTION    Erythrulose 1-phosphate = Glycerone phosphate + Formaldehyde
SUBSTRATE   Erythrulose 1-phosphate
PRODUCT     Glycerone phosphate
            Formaldehyde
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.2
            ExPASy - ENZYME nomenclature database: 4.1.2.2
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.2
            BRENDA, the Enzyme Database: 4.1.2.2
///
ENTRY       EC 4.1.2.3
NAME        Deleted entry
            Pentosealdolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.3
            ExPASy - ENZYME nomenclature database: 4.1.2.3
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.3
///
ENTRY       EC 4.1.2.4
NAME        Deoxyribose-phosphate aldolase
            Phosphodeoxyriboaldolase
            Deoxyriboaldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Deoxy-D-ribose-5-phosphate acetaldehyde-lyase
REACTION    2-Deoxy-D-ribose 5-phosphate = D-Glyceraldehyde 3-phosphate +
            Acetaldehyde
SUBSTRATE   2-Deoxy-D-ribose 5-phosphate
PRODUCT     D-Glyceraldehyde 3-phosphate
            Acetaldehyde
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b4381(deoC)
            ECE: Z5983(deoC)
            ECS: ECs5340
            YPE: YPO0436(deoC) YPO132(deoC) YPO3622
            HIN: HI1116(deoC)
            PMU: PM1343(deoC)
            VCH: VC2350
            MLO: mll4784
            SME: SMb21300(deoC)
            BSU: BG10983(dra)
            BHA: BH1352(dra)
            SAU: SA0133(dra) SA1939
            SAV: SAV0132(dra) SAV2123(dra)
            LLA: L63310(deoC)
            SPY: SPy1867(deoC)
            SPN: SP0843
            SPR: spr0745(deoC)
            CAC: CAC1545(deoC)
            MGE: MG050(deoC)
            MPN: D09_orf224(deoC)
            MPU: MYPU_3140(deoC)
            UUR: UU585(deoC)
            MTU: Rv0478(deoC)
            MTC: MT0496
            MLE: ML2451(deoC)
            TPA: TP0264
            SYN: sll1776(deoC)
            DRA: DR1205
            AAE: aq_148(deoC)
            TMA: TM1559
            MTH: MTH818
            HAL: VNG1859G(deoC)
            TAC: Ta0684
            TVO: TVG0183359
            APE: APE2437
            CEL: F09E5.3
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.4
            ExPASy - ENZYME nomenclature database: 4.1.2.4
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.4
            BRENDA, the Enzyme Database: 4.1.2.4
///
ENTRY       EC 4.1.2.5
NAME        Threonine aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     L-Threonine acetaldehyde-lyase
REACTION    L-Threonine = Glycine + Acetaldehyde
SUBSTRATE   L-Threonine
PRODUCT     Glycine
            Acetaldehyde
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       SME: SMb21134 SMc04029
            SCE: YEL046C(GLY1)
            SPO: SPAC23H3.09C(spac23h3.09c)
STRUCTURES  PDB: 1JG8  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.5
            ExPASy - ENZYME nomenclature database: 4.1.2.5
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.5
            BRENDA, the Enzyme Database: 4.1.2.5
///
ENTRY       EC 4.1.2.6
NAME        Deleted entry
            Allothreonine aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry. (reaction due to EC 2.1.2.1.)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.6
            ExPASy - ENZYME nomenclature database: 4.1.2.6
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.6
///
ENTRY       EC 4.1.2.7
NAME        Deleted entry
            Ketose-1-phosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry. Now included with EC 4.1.2.13.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.7
            ExPASy - ENZYME nomenclature database: 4.1.2.7
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.7
///
ENTRY       EC 4.1.2.8
NAME        Deleted entry
            Indoleglycerolphosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry. (a side-reaction of EC 4.2.1.20.)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.8
            ExPASy - ENZYME nomenclature database: 4.1.2.8
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.8
///
ENTRY       EC 4.1.2.9
NAME        Phosphoketolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     D-Xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase
REACTION    D-Xylulose 5-phosphate + Orthophosphate = Acetyl phosphate +
            D-Glyceraldehyde 3-phosphate + H2O
SUBSTRATE   D-Xylulose 5-phosphate
            Orthophosphate
PRODUCT     Acetyl phosphate
            D-Glyceraldehyde 3-phosphate
            H2O
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00680  Methane metabolism
            PATH: MAP00710  Carbon fixation
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.9
            ExPASy - ENZYME nomenclature database: 4.1.2.9
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.9
            BRENDA, the Enzyme Database: 4.1.2.9
///
ENTRY       EC 4.1.2.10
NAME        Mandelonitrile lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     Mandelonitrile benzaldehyde-lyase
REACTION    Mandelonitrile = Hydrogen cyanide + Benzaldehyde
SUBSTRATE   Mandelonitrile
PRODUCT     Hydrogen cyanide
            Benzaldehyde
COFACTOR    Flavin
COMMENT     A flavoprotein.
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
MOTIF       PS: PS00623  [GA]-[RKNC]-x-[LIV]-G(2)-[GST](2)-x-[LIVM]-N-x(3)-
                         [FYWA]-x(2)-[PAG]-x(5)-[DNESH]
            PS: PS00624  [GS]-[PSTA]-x(2)-[ST]-[PS]-x-[LIVM](2)-x(2)-S-G-[LIVM]-
                         G
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.10
            ExPASy - ENZYME nomenclature database: 4.1.2.10
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.10
            BRENDA, the Enzyme Database: 4.1.2.10
///
ENTRY       EC 4.1.2.11
NAME        Hydroxymandelonitrile lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     4-Hydroxymandelonitrile hydroxybenzaldehyde-lyase
REACTION    4-Hydroxymandelonitrile = Hydrogen cyanide + 4-Hydroxybenzaldehyde
SUBSTRATE   4-Hydroxymandelonitrile
PRODUCT     Hydrogen cyanide
            4-Hydroxybenzaldehyde
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
MOTIF       PS: PS00131  [LIVM]-x-[GTA]-E-S-Y-[AG]-[GS]
            PS: PS00560  [LIVF]-x(2)-[LIVSTA]-x-[IVPST]-x-[GSDNQL]-[SAGV]-[SG]-
                         H-x-[IVAQ]-P-x(3)-[PSA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.11
            ExPASy - ENZYME nomenclature database: 4.1.2.11
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.11
            BRENDA, the Enzyme Database: 4.1.2.11
///
ENTRY       EC 4.1.2.12
NAME        Ketopantoaldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     4-Dehydropantoate formaldehyde-lyase
REACTION    2-Hydroxy-2-isopropylbutanedioate = 3-Methyl-2-oxobutanoate +
            Formaldehyde
SUBSTRATE   2-Hydroxy-2-isopropylbutanedioate
PRODUCT     3-Methyl-2-oxobutanoate
            Formaldehyde
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.12
            ExPASy - ENZYME nomenclature database: 4.1.2.12
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.12
            BRENDA, the Enzyme Database: 4.1.2.12
///
ENTRY       EC 4.1.2.13
NAME        Fructose-bisphosphate aldolase
            Aldolase
            Fructose-1,6-bisphosphate triosephosphate-lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     D-Fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase
REACTION    D-Fructose 1,6-bisphosphate = Glycerone phosphate +
            D-Glyceraldehyde 3-phosphate;
            Sedoheptulose 1,7-bisphosphate = Glycerone phosphate +
            D-Erythrose 4-phosphate
SUBSTRATE   D-Fructose 1,6-bisphosphate
            (3S,4R)-Ketose 1-phosphate
            Sedoheptulose 1,7-bisphosphate
PRODUCT     Glycerone phosphate
            D-Glyceraldehyde 3-phosphate
            D-Erythrose 4-phosphate
COFACTOR    Zinc
COMMENT     Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial
            enzymes are zinc proteins.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00031  Inositol metabolism
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b2097(dhnA) b2925(fba)
            ECE: Z3260 Z4263(fba) Z5687
            ECS: ECs2900 ECs3796 ECs5069
            YPE: YPO0920(fbaA)
            HIN: HI0524(fba)
            PMU: PM1373(fbaA) PM1861(fba)
            XFA: XF0826
            VCH: VC0478
            PAE: PA0555(fda)
            BUC: BU451(fba)
            NME: NMB1869
            NMA: NMA0587(fba)
            HPY: HP0176(fba)
            HPJ: jhp0162
            CJE: Cj0597(fba)
            MLO: mll7273 mlr3754
            SME: SMb20199(cbbA) SMb21192(cbbA2) SMc03983(fbaB)
            CCR: CC3250
            BSU: BG10412(fbaA) BG11125(iolJ)
            BHA: BH2314 BH3786(fbaA)
            SAU: SA1927(fbaA) SA2399
            SAV: SAV2112(fbaA) SAV2590
            LLA: L0009(fbaA)
            SPY: SPy1889(fba)
            SPN: SP0605
            SPR: spr0530(fba)
            CAC: CAC0827
            MGE: MG023(fba)
            MPN: B01_orf288(fba)
            MPU: MYPU_1100(fba) MYPU_3600(fba)
            UUR: UU596(tsr)
            MTU: Rv0363c(fba)
            MTC: MT0379
            MLE: ML0286(fba)
            CTR: CT215
            CMU: TC0487
            CPN: CPn0281
            CPA: CP0477
            CPJ: dhnA
            BBU: BB0445(fba)
            TPA: TP0662
            SYN: sll0018(cbbA) slr0943(fda)
            DRA: DR1589
            AAE: aq_1390(fba)
            TMA: TM0273
            MJA: MJ0109
            AFU: AF2372(suhB)
            PHO: PH1897
            PAB: PAB0189(imp1)
            SCE: YKL060C(FBA1)
            SPO: FBA1(fba1)
            ATH: At4g26520(M3E9.50)
            CEL: F01F1.12 T05D4.1
            DME: CG6058(Ald) CG6058_1(Ald)
            MMU: 87995(Aldo2)
            HSA: 226(ALDOA) 229(ALDOB) 230(ALDOC)
DISEASE     MIM: 103850  Aldolase A, fructose-bisphosphatase
            MIM: 103870  Aldolase C, fructose-bisphosphatase
            MIM: 229600  Aldolase B, fructose-bisphosphatase
MOTIF       PS: PS00158  [LIVM]-x-[LIVMFYW]-E-G-x-[LS]-L-K-P-[SN]
            PS: PS00602  [FYVMT]-x(1,3)-[LIVMH]-[APNT]-[LIVM]-x(1,2)-[LIVM]-H-x-
                         D-H-[GACH]
            PS: PS00806  [LIVM]-E-x-E-[LIVM]-G-x(2)-[GM]-[GSTA]-x-E
STRUCTURES  PDB: 1ADO  1ALD  1B57  1DOS  1EPX  1EWD  1A5C  1EWG  1EX5  1F2J  
                 1FBA  1FDJ  1QO5  1ZEN  2ALD  4ALD  6ALD  1EWE  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.13
            ExPASy - ENZYME nomenclature database: 4.1.2.13
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.13
            BRENDA, the Enzyme Database: 4.1.2.13
            SCOP (Structural Classification of Proteins): 4.1.2.13
///
ENTRY       EC 4.1.2.14
NAME        2-Dehydro-3-deoxyphosphogluconate aldolase
            Phospho-2-keto-3-deoxygluconate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-
            -3-phosphate-lyase
REACTION    2-Dehydro-3-deoxy-D-gluconate 6-phosphate = Pyruvate +
            D-Glyceraldehyde 3-phosphate
SUBSTRATE   2-Dehydro-3-deoxy-D-gluconate 6-phosphate
            2-Oxobutanoate
PRODUCT     Pyruvate
            D-Glyceraldehyde 3-phosphate
COMMENT     Also acts on 2-oxobutanoate.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b1850(eda)
            ECE: Z2902(eda)
            ECS: ECs2560
            HIN: HI0047(eda)
            PMU: PM0947(eda)
            XFA: XF1061
            VCH: VC0285
            PAE: PA3131 PA3181
            NME: NMB1394
            NMA: NMA1611(eda)
            HPY: HP1099(eda)
            HPJ: jhp1025
            MLO: mlr2994
            SME: SMc02043(eda1) SMc03153(eda2)
            CCR: CC0784 CC1495
            BSU: BG11396(kdgA)
            BHA: BH3723(kdgA)
            LLA: L0022(kdgA)
            SPY: SPy0639(kgdA)
            SPN: SP0317
            SPR: spr0287(kdgA)
            CAC: CAC0394(kdgA) CAC2973(kdgA)
            TPA: TP0568
            SYN: sll0107(eda)
            TMA: TM0066
MOTIF       PS: PS00159  G-[LIVM]-x(3)-E-[LIV]-T-[LF]-R
            PS: PS00160  G-x(3)-[LIVMF]-K-[LF]-F-P-[SA]-x(3)-G
STRUCTURES  PDB: 1EUA  1EUN  1FQ0  1FWR  1KGA  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.14
            ExPASy - ENZYME nomenclature database: 4.1.2.14
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.14
            BRENDA, the Enzyme Database: 4.1.2.14
            SCOP (Structural Classification of Proteins): 4.1.2.14
///
ENTRY       EC 4.1.2.15
NAME        2-Dehydro-3-deoxyphosphoheptonate aldolase
            Phospho-2-keto-3-deoxyheptonate aldolase
            DHAP synthase
            KDPH synthetase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-arabino-heptonate-7-phosphate d-erythrose-
            -4-phosphate-lyase (pyruvate-phosphorylating)
REACTION    2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + 
            Orthophosphate = Phosphoenolpyruvate + D-Erythrose 4-phosphate + 
            H2O
SUBSTRATE   2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
            Orthophosphate
PRODUCT     Phosphoenolpyruvate
            D-Erythrose 4-phosphate
            H2O
COFACTOR    Cadmium
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b0754(aroG) b1704(aroH) b2601(aroF)
            ECE: Z0924(aroG) Z2733(aroH) Z3893(aroF)
            ECS: ECs0782 ECs2411 ECs3464
            YPE: YPO1130(aroG) YPO2411(aroH) YPO3286(aroF)
            HIN: HI1547(aroG)
            PMU: PM0563(aroG) PM0665(aroF)
            XFA: XF0026
            VCH: VC0695 VC1507
            PAE: PA1750 PA2843 PA2943
            BUC: BU124(aroH)
            NME: NMB0307
            NMA: NMA2180(aroG)
            HPY: HP0134(dhs1)
            HPJ: jhp0122
            CJE: Cj0716
            MLO: mll0826 mll4988
            SME: SMc00155(aroF)
            CCR: CC1397 CC2300
            BSU: BG10375(aroA)
            BHA: BH3242(aroA)
            SAU: SA1558
            SAV: SAV1724
            LLA: L0063(aroF) L0064(aroH)
            SPN: SP1701
            SPR: spr1542(aroF) spr1543(aroG)
            CAC: CAC0892
            MTU: Rv2178c
            MTC: MT2234
            MLE: ML0896(aroG)
            CTR: CT382
            CMU: TC0661
            CPN: CPn0484
            CPA: CP0270
            CPJ: aroG
            SYN: sll0934(ccmA)
            DRA: DR1001 DR1817
            AAE: aq_1121
            TMA: TM0343
            TAC: Ta0247
            TVO: TVG1422507
            PAB: PAB0297(aroG)
            APE: APE0581
            SSO: SSO0304(aroG)
            SCE: YBR249C(ARO4) YDR035W(ARO3)
            SPO: SPAC24H6.10C(spac24h6.10c) SPAP8A3.07C(spap8a3.07c)
            ATH: At4g33510(F17M5.270) At4g39980(T5J17.150)
STRUCTURES  PDB: 1QR7  1GG1  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.15
            ExPASy - ENZYME nomenclature database: 4.1.2.15
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.15
            BRENDA, the Enzyme Database: 4.1.2.15
            SCOP (Structural Classification of Proteins): 4.1.2.15
///
ENTRY       EC 4.1.2.16
NAME        2-Dehydro-3-deoxyphosphooctonate aldolase
            Phospho-2-keto-3-deoxyoctonate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-
            -lyase (pyruvate-phosphorylating)
REACTION    2-Dehydro-3-deoxy-D-octonate 8-phosphate + Orthophosphate =
            Phosphoenolpyruvate + D-Arabinose 5-phosphate + H2O
SUBSTRATE   2-Dehydro-3-deoxy-D-octonate 8-phosphate
            Orthophosphate
PRODUCT     Phosphoenolpyruvate
            D-Arabinose 5-phosphate
            H2O
PATHWAY     PATH: MAP00540  Lipopolysaccharide biosynthesis
GENES       ECO: b1215(kdsA)
            ECE: Z1986(kdsA)
            ECS: ECs1720
            YPE: YPO2021(kdsA)
            HIN: HI1557(kdsA)
            PMU: PM0558(kdsA)
            XFA: XF1289
            VCH: VC2175
            PAE: PA3636(kdsA)
            NME: NMB1283
            NMA: NMA1493(kdsA)
            HPY: HP0003(kdsA)
            HPJ: jhp0003
            CJE: Cj0384c(kdsA)
            RPR: RP062(kdsA)
            RCO: RC0090(kdsA)
            MLO: mlr0374
            SME: SMc01027(kdsA)
            CCR: CC1429
            CTR: CT655
            CMU: TC0025
            CPN: CPn0721
            CPA: CP0025
            CPJ: kdsA
            AAE: aq_085(kdsA)
STRUCTURES  PDB: 1D9E  1FWN  1FWS  1FWT  1FWW  1FX6  1FXP  1FXQ  1FY6  1G7U  
                 1GG0  1G7V  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.16
            ExPASy - ENZYME nomenclature database: 4.1.2.16
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.16
            BRENDA, the Enzyme Database: 4.1.2.16
            SCOP (Structural Classification of Proteins): 4.1.2.16
///
ENTRY       EC 4.1.2.17
NAME        L-Fuculose-phosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     L-Fuculose-1-phosphate lactaldehyde-lyase
REACTION    L-Fuculose 1-phosphate = Glycerone phosphate + (S)-Lactaldehyde
SUBSTRATE   L-Fuculose 1-phosphate
PRODUCT     Glycerone phosphate
            (S)-Lactaldehyde
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2800(fucA)
            ECE: Z4117(fucA)
            ECS: ECs3660
            HIN: HI0611(fucA)
            SME: SMc01621(fucA1)
            SPN: SP2166
            SPR: spr1972(fucA)
            MTU: Rv0727c(fucA)
            MTC: MT0752
            AAE: aq_1658(fucA1) aq_1979(fucA2)
            MJA: MJ1418(fucA)
            MTH: MTH1406
            AFU: AF0480(fucA)
            HAL: VNG1201G(fucA)
            TVO: TVG1526682
            PHO: PH0191
            PAB: PAB0117(fucA)
            APE: APE1657
STRUCTURES  PDB: 1DZV  1DZU  1DZX  1DZY  1DZZ  1E46  1E47  1E48  1DZW  1E4A  
                 1E4B  1E4C  1FUA  2FUA  3FUA  4FUA  1E49  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.17
            ExPASy - ENZYME nomenclature database: 4.1.2.17
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.17
            BRENDA, the Enzyme Database: 4.1.2.17
            SCOP (Structural Classification of Proteins): 4.1.2.17
///
ENTRY       EC 4.1.2.18
NAME        2-Dehydro-3-deoxy-L-pentonate aldolase
            2-Keto-3-deoxy-L-pentonate aldolase
            2-Keto-3-deoxy-L-arabonate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-L-pentanoate glycolaldehyde
REACTION    2-Dehydro-3-deoxy-L-pentanoate = Pyruvate + Glycolaldehyde
SUBSTRATE   2-Dehydro-3-deoxy-L-pentanoate
PRODUCT     Pyruvate
            Glycolaldehyde
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.18
            ExPASy - ENZYME nomenclature database: 4.1.2.18
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.18
            BRENDA, the Enzyme Database: 4.1.2.18
///
ENTRY       EC 4.1.2.19
NAME        Rhamnulose-1-phosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     L-Rhamnulose-1-phosphate lactaldehyde-lyase
REACTION    L-Rhamnulose 1-phosphate = Glycerone phosphate + (S)-Lactaldehyde
SUBSTRATE   L-Rhamnulose 1-phosphate
PRODUCT     Glycerone phosphate
            (S)-Lactaldehyde
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b3902(rhaD)
            ECE: Z5446(rhaD)
            ECS: ECs4829
            YPE: YPO0328(rhaD)
            TMA: TM1072
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.19
            ExPASy - ENZYME nomenclature database: 4.1.2.19
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.19
            BRENDA, the Enzyme Database: 4.1.2.19
///
ENTRY       EC 4.1.2.20
NAME        2-Dehydro-3-deoxyglucarate aldolase
            2-Keto-3-deoxyglucarate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase
REACTION    2-Dehydro-3-deoxy-D-glucarate = Pyruvate + Tartronate semialdehyde
SUBSTRATE   2-Dehydro-3-deoxy-D-glucarate
PRODUCT     Pyruvate
            Tartronate semialdehyde
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
STRUCTURES  PDB: 1DXF  1DXE  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.20
            ExPASy - ENZYME nomenclature database: 4.1.2.20
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.20
            BRENDA, the Enzyme Database: 4.1.2.20
            SCOP (Structural Classification of Proteins): 4.1.2.20
///
ENTRY       EC 4.1.2.21
NAME        2-Dehydro-3-deoxyphosphogalactonate aldolase
            6-Phospho-2-dehydro-3-deoxygalactonate aldolase
            6-Phospho-2-keto-3-deoxygalactonate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-
            $phosphate-lyase
REACTION    2-Dehydro-3-deoxy-D-galactonate 6-phosphate = Pyruvate +
            D-Glyceraldehyde 3-phosphate
SUBSTRATE   2-Dehydro-3-deoxy-D-galactonate 6-phosphate
PRODUCT     Pyruvate
            D-Glyceraldehyde 3-phosphate
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       ECO: b3692(dgoA)
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
            PS: PS00909  [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-
                         [LIVM]-E-[DENQ]-P
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.21
            ExPASy - ENZYME nomenclature database: 4.1.2.21
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.21
            BRENDA, the Enzyme Database: 4.1.2.21
///
ENTRY       EC 4.1.2.22
NAME        Fructose-6-phosphate phosphoketolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     D-Fructose-6-phosphate D-erythrose-4-phosphate-lyase
REACTION    D-Fructose 6-phosphate + Orthophosphate = Acetyl phosphate +
            D-Erythrose 4-phosphate + H2O
SUBSTRATE   D-Fructose 6-phosphate
            Orthophosphate
            D-Xylulose 5-phosphate
PRODUCT     Acetyl phosphate
            D-Erythrose 4-phosphate
            H2O
COMMENT     Also acts on D-xylulose 5-phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.22
            ExPASy - ENZYME nomenclature database: 4.1.2.22
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.22
            BRENDA, the Enzyme Database: 4.1.2.22
///
ENTRY       EC 4.1.2.23
NAME        3-Deoxy-D-manno-octulosonate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     3-Deoxy-D-manno-octulosonate D-arabinose-lyase
REACTION    3-Deoxy-D-manno-octulosonate = Pyruvate + D-Arabinose
SUBSTRATE   3-Deoxy-D-manno-octulosonate
PRODUCT     Pyruvate
            D-Arabinose
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.23
            ExPASy - ENZYME nomenclature database: 4.1.2.23
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.23
            BRENDA, the Enzyme Database: 4.1.2.23
///
ENTRY       EC 4.1.2.24
NAME        Dimethylaniline-N-oxide aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     N,N-Dimethylaniline-N-oxide formaldehyde-lyase
REACTION    N,N-Dimethylaniline N-oxide = N-Methylaniline + Formaldehyde
SUBSTRATE   N,N-Dimethylaniline N-oxide
PRODUCT     N-Methylaniline
            Formaldehyde
COMMENT     Acts on various N,N-dialkylarylamide.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.24
            ExPASy - ENZYME nomenclature database: 4.1.2.24
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.24
            BRENDA, the Enzyme Database: 4.1.2.24
///
ENTRY       EC 4.1.2.25
NAME        Dihydroneopterin aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-
            $7,8-dihydropteridine glycolaldehyde-lyase
REACTION    2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-
            $7,8-dihydropteridine = Glycolaldehyde +
            2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
SUBSTRATE   2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-
            $7,8-dihydropteridine
PRODUCT     Glycolaldehyde
            2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b3058(folB)
            ECE: Z4411(ygiG)
            ECS: ECs3941
            YPE: YPO0648(folB)
            HIN: HI0265
            PMU: PM1697(folB)
            XFA: XF0436
            VCH: VC0524
            PAE: PA0582(folB)
            NME: NMB1063
            NMA: NMA1262(folB)
            HPY: HP1510
            HPJ: jhp1403
            MLO: mll0787
            SME: SMc00463(folB)
            CCR: CC0416
            BSU: BG10141(folA)
            BHA: BH0094(folA)
            SAU: SA0473(folB)
            SAV: SAV0505(folB)
            LLA: L165490(folB)
            SPY: SPy1099(folQ)
            SPN: SP0292
            SPR: spr0269(sulD)
            CAC: CAC2927(folA/folK)
            MTU: Rv3607c(folX)
            MLE: ML0225(folB)
            CTR: CT614
            CMU: TC0904
            CPN: CPn0757
            CPA: CP1115
            CPJ: folX
            SYN: slr1626(folB)
            DRA: DR0169
            SCE: YNL256W(FOL1)
            ATH: At5g62980(MJH22.3)
MOTIF       PS: PS00792  [LIVM]-x-[AG]-[LIVMF](2)-N-x-T-x-D-S-F-x-D-x-[SG]
            PS: PS00793  [GE]-[SA]-x-[LIVM](2)-D-[LIVM]-G-[GP]-x(2)-[STA]-x-P
            PS: PS00794  [KRHD]-x-[GA]-[PSAE]-R-x(2)-D-[LIV]-D-[LIVM](2)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.25
            ExPASy - ENZYME nomenclature database: 4.1.2.25
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.25
            BRENDA, the Enzyme Database: 4.1.2.25
///
ENTRY       EC 4.1.2.26
NAME        Phenylserine aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     L-threo-3-Phenylserine benzaldehyde-lyase
REACTION    L-threo-3-Phenylserine = Glycine + Benzaldehyde
SUBSTRATE   L-threo-3-Phenylserine
PRODUCT     Glycine
            Benzaldehyde
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.26
            ExPASy - ENZYME nomenclature database: 4.1.2.26
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.26
            BRENDA, the Enzyme Database: 4.1.2.26
///
ENTRY       EC 4.1.2.27
NAME        Sphinganine-1-phosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     Sphinganine-1-phosphate pamlmitaldehyde-lyase
REACTION    Sphinganine 1-phosphate = Phosphoethanolamine + Palmitaldehyde
SUBSTRATE   Sphinganine 1-phosphate
PRODUCT     Phosphoethanolamine
            Palmitaldehyde
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.27
            ExPASy - ENZYME nomenclature database: 4.1.2.27
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.27
            BRENDA, the Enzyme Database: 4.1.2.27
///
ENTRY       EC 4.1.2.28
NAME        2-Dehydro-3-deoxy-D-pentonate aldolase
            2-Keto-3-deoxy-D-pentonate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Dehydro-3-deoxy-D-pentanoate glycoaldehyde-lyase
REACTION    2-Dehydro-3-deoxy-D-pentanoate = Pyruvate + Glycolaldehyde
SUBSTRATE   2-Dehydro-3-deoxy-D-pentanoate
PRODUCT     Pyruvate
            Glycolaldehyde
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.28
            ExPASy - ENZYME nomenclature database: 4.1.2.28
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.28
            BRENDA, the Enzyme Database: 4.1.2.28
///
ENTRY       EC 4.1.2.29
NAME        5-Dehydro-2-deoxyphosphogluconate aldolase
            Phospho-5-dehydro-2-deoxygluconate aldolase
            Phospho-5-keto-2-deoxygluconate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     5-Dehydro-2-deoxy-D-glyconate-6-phosphate malonate-semialdehyde-
            $lyase
REACTION    5-Dehydro-2-deoxy-D-gluconate 6-phosphate = Glycerone phosphate +
            Malonate semialdehyde
SUBSTRATE   5-Dehydro-2-deoxy-D-gluconate 6-phosphate
PRODUCT     Glycerone phosphate
            Malonate semialdehyde
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.29
            ExPASy - ENZYME nomenclature database: 4.1.2.29
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.29
            BRENDA, the Enzyme Database: 4.1.2.29
///
ENTRY       EC 4.1.2.30
NAME        17alpha-Hydroxyprogesterone aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     17alpha-Hydroxyprogesterone acetaldehyde-lyase
REACTION    17alpha-Hydroxyprogesterone = 4-Androstene-3,17-dione +
            Acetaldehyde
SUBSTRATE   17alpha-Hydroxyprogesterone
PRODUCT     4-Androstene-3,17-dione
            Acetaldehyde
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.30
            ExPASy - ENZYME nomenclature database: 4.1.2.30
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.30
            BRENDA, the Enzyme Database: 4.1.2.30
///
ENTRY       EC 4.1.2.31
NAME        Deleted entry
            2-Oxo-4-hydroxyglutarate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
COMMENT     Deleted entry. Now included with EC 4.1.3.16.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.31
            ExPASy - ENZYME nomenclature database: 4.1.2.31
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.31
///
ENTRY       EC 4.1.2.32
NAME        Trimethylamine-oxide aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     Trimethylamine-N-oxide formaldehyde-lyase
REACTION    (CH3)3NO = Dimethylamine + Formaldehyde
SUBSTRATE   Trimethylamine N-oxide
PRODUCT     Dimethylamine
            Formaldehyde
PATHWAY     PATH: MAP00680  Methane metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.32
            ExPASy - ENZYME nomenclature database: 4.1.2.32
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.32
            BRENDA, the Enzyme Database: 4.1.2.32
///
ENTRY       EC 4.1.2.33
NAME        Fucosterol-epoxide lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     (24R,24'R)-Fucosterol-epoxide acetaldehyde-lyase
REACTION    (24R,24'R)-Fucosterol epoxide = Desmosterol + Acetaldehyde
SUBSTRATE   (24R,24'R)-Fucosterol epoxide
PRODUCT     Desmosterol
            Acetaldehyde
COMMENT     The insect enzyme is involved in the conversion of sitosterol into
            cholesterol.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.33
            ExPASy - ENZYME nomenclature database: 4.1.2.33
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.33
            BRENDA, the Enzyme Database: 4.1.2.33
///
ENTRY       EC 4.1.2.34
NAME        4-(2-Carboxyphenyl)-2-oxobut-3-enoate aldolase
            2'-Carboxybenzalpyruvate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     (3E)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-
            $lyase
REACTION    (3E)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate = 2-Carboxybenzaldehyde
            + Pyruvate
SUBSTRATE   (3E)-4-(2-Carboxyphenyl)-2-oxobut-3-enoate
PRODUCT     2-Carboxybenzaldehyde
            Pyruvate
COMMENT     Involved with EC 1.13.11.38, in the metabolism of phenanthrene in
            bacteria.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.34
            ExPASy - ENZYME nomenclature database: 4.1.2.34
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.34
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.2.34
            BRENDA, the Enzyme Database: 4.1.2.34
///
ENTRY       EC 4.1.2.35
NAME        Propioin synthase
            4-Hydroxy-3-hexanone aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     4-Hydroxy-3-hexanone propanal-lyase
REACTION    2 Propanal = 4-Hydroxyhexan-3-one
SUBSTRATE   Propanal
PRODUCT     4-Hydroxyhexan-3-one
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.35
            ExPASy - ENZYME nomenclature database: 4.1.2.35
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.35
            BRENDA, the Enzyme Database: 4.1.2.35
///
ENTRY       EC 4.1.2.36
NAME        Lactate aldolase
            Lactate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     (S)-Lactate acetaldehyde-lyase
REACTION    (S)-Lactate = Formate + Acetaldehyde
SUBSTRATE   (S)-Lactate
PRODUCT     Formate
            Acetaldehyde
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.36
            ExPASy - ENZYME nomenclature database: 4.1.2.36
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.36
            BRENDA, the Enzyme Database: 4.1.2.36
///
ENTRY       EC 4.1.2.37
NAME        Acetone-cyanohydrin lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     Acetone-cyanohydrin acetone-lyase
REACTION    Acetone cyanohydrin = Hydrogen cyanide + Acetone
SUBSTRATE   Acetone cyanohydrin
PRODUCT     Hydrogen cyanide
            Acetone
COMMENT     Not identical with EC 4.1.2.10 or 4.1.2.11.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.37
            ExPASy - ENZYME nomenclature database: 4.1.2.37
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.37
            BRENDA, the Enzyme Database: 4.1.2.37
///
ENTRY       EC 4.1.2.38
NAME        Benzoin aldolase
            Benzaldehyde lyase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
SYSNAME     2-Hydroxy-1,2-diphenylethanone benzaldehyde-lyase
REACTION    Benzoin = 2 Benzaldehyde
SUBSTRATE   Benzoin
PRODUCT     Benzaldehyde
COFACTOR    Thiamine diphosphate
COMMENT     A thiamine-diphosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.38
            ExPASy - ENZYME nomenclature database: 4.1.2.38
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.38
            BRENDA, the Enzyme Database: 4.1.2.38
///
ENTRY       EC 4.1.2.39
NAME        (S)-Hydroxynitrilase
            (S)-Hydroxynitrile lyase
            (S)-Oxynitrilase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
REACTION    (S)-2-Hydroxyisobutyronitrile = Hydrogen cyanide + Acetone
SUBSTRATE   (S)-2-Hydroxyisobutyronitrile
PRODUCT     Hydrogen cyanide
            Acetone
COMMENT     Accepts aliphatic and aromatic Hydroxynitriles. Unlike
            EC 4.1.2.11 which aliphatic and aromatic Hydroxynitriles.
            S-2-Hydroxyisoburyronitrile (Acetone cyanohydrin) is
            liberated by Glycosidase action on Linamarin.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.39
            ExPASy - ENZYME nomenclature database: 4.1.2.39
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.39
///
ENTRY       EC 4.1.2.40
NAME        Tagatose-bisphosphate aldolase
            D-Tagatose-1,6-bisphosphate aldolase
            Tagatose 1,6-diphosphate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Aldehyde-lyases
REACTION    D-Tagatose 1,6-bisphosphate = Glycerone phosphate +
            D-Glyceraldehyde 3-phosphate
SUBSTRATE   D-Tagatose 1,6-bisphosphate
PRODUCT     Glycerone phosphate
            D-Glyceraldehyde 3-phosphate
COMMENT     Enzyme activity is stimulated by certain divalent cations.
            Involved in the tagatose 6-phosphate pathway of lactose catabolism
            in bacteria.
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       MLO: mlr3411
            SAU: SA1994(lacD)
            SAV: SAV2178(lacD)
            SPY: SPy1704(lacD.1) SPy1919(lacD.2)
            SPN: SP1190
            SPR: spr1073(lacD)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.2.40
            ExPASy - ENZYME nomenclature database: 4.1.2.40
            WIT (What Is There) Metabolic Reconstruction: 4.1.2.40
///
ENTRY       EC 4.1.3.1
NAME        Isocitrate lyase
            Isocitrase
            Isocitritase
            Isocitratase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Isocitrate glyoxylate-lyase
REACTION    Isocitrate = Succinate + Glyoxylate
SUBSTRATE   Isocitrate
            (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
PRODUCT     Succinate
            Glyoxylate
COMMENT     The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-
            1,2,3-tricarboxylate.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b4015(aceA)
            ECE: Z5601(aceA)
            ECS: ECs4933
            YPE: YPO3725(aceA)
            VCH: VC0736
            PAE: PA2634
            MLO: mll6527
            SME: SMc00768(aceA)
            CCR: CC1764
            BHA: BH2677
            MTU: Rv0467(aceA) Rv1915(aceAa) Rv1916(aceAb)
            MTC: MT0483 MT1966
            MLE: ML1985(aceA)
            DRA: DR0828
            SSO: SSO1333(aceA/icl)
            SCE: YER065C(ICL1) YPR006C(ICL2)
            SPO: SPBC1683.11C(spbc1683.11c)
MOTIF       PS: PS00161  K-[KR]-C-G-H-[LMQR]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1DQU  1F61  1F8I  1F8M  1IGW  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.1
            ExPASy - ENZYME nomenclature database: 4.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.1
            BRENDA, the Enzyme Database: 4.1.3.1
            SCOP (Structural Classification of Proteins): 4.1.3.1
///
ENTRY       EC 4.1.3.2
NAME        Malate synthase
            Malate condensing enzyme
            Glyoxylate transacetylase
            Malate synthetase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     L-Malate glyoxylate-lyase (CoA-acetylating)
REACTION    L-Malate + CoA = Acetyl-CoA + H2O + Glyoxylate
SUBSTRATE   L-Malate
            CoA
PRODUCT     Acetyl-CoA
            H2O
            Glyoxylate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b2976(glcB) b4014(aceB)
            ECE: Z5600(aceB)
            ECS: ECs4932
            YPE: YPO3726(aceB)
            VCH: VC0734
            PAE: PA0482(glcB)
            MLO: mlr4664
            SME: SMc02581(glcB)
            ATU: AGR_C_78
            CCR: CC1765
            BHA: BH2133
            MTU: Rv1837c(glcB)
            MTC: MT1885
            MLE: ML2069(glcB)
            DRA: DR1155 DRA0277
            SSO: SSO1334(aceB/mas)
            SCE: YIR031C(DAL7) YNL117W(MLS1)
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00510  [KR]-[DENQ]-H-x(2)-G-L-N-x-G-x-W-D-Y-[LIVM]-F
STRUCTURES  PDB: 1D8C  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.2
            ExPASy - ENZYME nomenclature database: 4.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.2
            BRENDA, the Enzyme Database: 4.1.3.2
            SCOP (Structural Classification of Proteins): 4.1.3.2
///
ENTRY       EC 4.1.3.3
NAME        N-Acetylneuraminate lyase
            N-Acetylneuraminic acid aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     N-Acetylneuraminate pyruvate-lyase
REACTION    N-Acetylneuraminate = N-Acetyl-D-mannosamine + Pyruvate
SUBSTRATE   N-Acetylneuraminate
            N-Glycoloyl-neuraminate
            O-Acetylated sialic acid
PRODUCT     N-Acetyl-D-mannosamine
            Pyruvate
COMMENT     Also acts on N-glycoloyl-neuraminate and on O-acetylated sialic
            acids, other than O4-acetylated derivatives.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3225(nanA)
            ECE: Z4583(nanA)
            ECS: ECs4098
            YPE: YPO3024(nanA)
            HIN: HI0142(nanA)
            PMU: PM1715(nanA)
            VCH: VC1776
            SAU: SA0304(nanA)
            SAV: SAV0305(nanA)
            SPY: SPy0257(nanH)
            SPN: SP1676
            SPR: spr1186(npl-truncation) spr1520(npl-truncation)
MOTIF       PS: PS00665  [GSA]-[LIVM]-[LIVMFY]-x(2)-G-[ST]-[TG]-G-E-[GASNF]-
                         x(6)-[EQ]
            PS: PS00666  Y-[DNS]-[LIVMFA]-P-x(2)-[ST]-x(3)-[LIVMF]-x(13,14)-
                         [LIVM]-x-[SGA]-[LIVMF]-K-[DEQAF]-[STAC]
STRUCTURES  PDB: 1NAL  1FDZ  1FDY  1F7B  1F74  1F5Z  1F6K  1F6P  1F73  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.3
            ExPASy - ENZYME nomenclature database: 4.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.3
            BRENDA, the Enzyme Database: 4.1.3.3
            SCOP (Structural Classification of Proteins): 4.1.3.3
///
ENTRY       EC 4.1.3.4
NAME        Hydroxymethylglutaryl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetate-lyase
REACTION    (S)-3-Hydroxy-3-methylglutaryl-CoA = Acetyl-CoA + Acetoacetate
SUBSTRATE   (S)-3-Hydroxy-3-methylglutaryl-CoA
PRODUCT     Acetyl-CoA
            Acetoacetate
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00650  Butanoate metabolism
GENES       PAE: PA2011
            SME: SMb21125(hmgL)
            CCR: CC0467
            BSU: BG13458(yngG)
            BHA: BH1134
            ATH: At2g26800(F12C20.16)
            DME: CG10399
            MMU: 96158(Hmgcl)
            HSA: 3155(HMGCL)
DISEASE     MIM: 246450  3-hydroxy-3-methylglutaryl-Coenzyme A lyase
MOTIF       PS: PS01062  S-V-A-G-L-G-G-C-P-Y
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.4
            ExPASy - ENZYME nomenclature database: 4.1.3.4
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.4
            BRENDA, the Enzyme Database: 4.1.3.4
///
ENTRY       EC 4.1.3.5
NAME        Hydroxymethylglutaryl-CoA synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase
            (CoA-acetylating)
REACTION    (S)-3-Hydroxy-3-methylglutaryl-CoA + CoA = Acetyl-CoA +
            H2O + Acetoacetyl-CoA
SUBSTRATE   (S)-3-Hydroxy-3-methylglutaryl-CoA
            CoA
PRODUCT     Acetyl-CoA
            H2O
            Acetoacetyl-CoA
PATHWAY     PATH: MAP00072  Synthesis and degradation of ketone bodies
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00650  Butanoate metabolism
GENES       SAU: SA2334(mvaS)
            SAV: SAV2529
            LLA: L13187(hmcM)
            SPY: SPy0881(mvaS.2)
            SPN: SP1727
            BBU: BB0683
            HAL: VNG1615G(mvaB)
            SCE: YML126C(HMGS)
            SPO: HCS(hcs)
            ATH: At4g11820(T26M18.30)
            CEL: F25B4.6
            DME: CG4311_1
            MMU: 101939(Hmgcs2)
            HSA: 3157(HMGCS1) 3158(HMGCS2)
DISEASE     MIM: 142940  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            MIM: 600234  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
MOTIF       PS: PS01226  N-x-[DN]-[IV]-E-G-[IV]-D-x(2)-N-A-C-[FY]-x-G
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.5
            ExPASy - ENZYME nomenclature database: 4.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.5
            BRENDA, the Enzyme Database: 4.1.3.5
///
ENTRY       EC 4.1.3.6
NAME        Citrate lyase
            Citrase
            Citratase
            Citritase
            Citridesmolase
            Citrate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     [Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate)]
REACTION    Citrate = Acetate + Oxaloacetate
SUBSTRATE   Citrate
PRODUCT     Acetate
            Oxaloacetate
COMMENT     The enzyme can be dissociated into components, two of which are
            identical with EC 2.8.3.10 and 4.1.3.34.  EC 3.1.2.16 deacetylates
            and inactivates the enzyme.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b0615(citF) b0616(citE)
            ECE: Z0759(citF) Z0760(citE)
            ECS: ECs0654 ECs0655
            HIN: HI0022(citF) HI0023(citE)
            VCH: VC0798 VC0799
            PAE: PA0883
            MLO: mll6008 mlr0906 mlr4422
            SME: SMc03793(citE)
            CCR: CC3659
            LLA: L0040(citE) L0041(citF)
            SPY: SPy1186(citD) SPy1188(citE) SPy1189(citF)
            MTU: Rv2498c(citE)
            MTC: MT2573
            DRA: DR1240 DR2206
            HAL: VNG0627G(citE)
            APE: APE0311
            SSO: SSO1254(citE)
            CEL: C01G10.7
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.6
            ExPASy - ENZYME nomenclature database: 4.1.3.6
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.6
            BRENDA, the Enzyme Database: 4.1.3.6
///
ENTRY       EC 4.1.3.7
NAME        Citrate (si)-synthase
            Condensing enzyme
            Citrate condensing enzyme
            Citrogenase
            Oxaloacetate transacetase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -> acetyl-CoA)
REACTION    Citrate + CoA = Acetyl-CoA + H2O + Oxaloacetate
SUBSTRATE   Citrate
            CoA
PRODUCT     Acetyl-CoA
            H2O
            Oxaloacetate
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b0720(gltA)
            ECE: Z0873(gltA)
            ECS: ECs0745
            YPE: YPO1108(gltA)
            PMU: PM0276(gltA)
            XFA: XF1535
            VCH: VC2092
            PAE: PA1580(gltA)
            NME: NMB0954
            NMA: NMA1148(gltA)
            HPY: HP0026(gltA)
            HPJ: jhp0022
            CJE: Cj1682c(gltA)
            RPR: RP844(gltA)
            RCO: RC1308(gltA)
            MLO: mll3842 mlr0629 mlr3843
            SME: SMc02087(gltA)
            CCR: CC1906 CC3642
            BSU: BG10854(citA) BG10855(citZ) BG11322(mmgD)
            BHA: BH3160(citZ) BH3924(mmgD)
            SAU: SA1518(citZ)
            SAV: SAV1681(citZ)
            LLA: L67186(gltA)
            MTU: Rv0889c(citA) Rv0896(gltA2) Rv1131(gltA1)
            MTC: MT0912 MT0920 MT1163
            MLE: ML2130(gltA2)
            SYN: sll0401(gltA)
            DRA: DR0757
            AAE: aq_150(gltA)
            TMA: TM0290
            MTH: MTH1726 MTH962
            AFU: AF1340(citZ)
            HAL: VNG2102G(citZ)
            TAC: Ta0169 Ta0819
            TVO: TVG0252956
            APE: APE1713
            SSO: SSO2589
            STO: ST0587
            SCE: YCR005C(CIT2) YNR001C(CIT1) YPR001W(CIT3)
            SPO: SPAC6C3.04(spac6c3.04)
            ATH: At2g44350(F4I1.22)
            DME: CG3861
            MMU: 88529
            HSA: 1431
DISEASE     MIM: 118950  Citrate synthase, mitochondrial
MOTIF       PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00480  G-[FYA]-[GA]-H-x-[IV]-x(1,2)-[RKT]-x(2)-D-[PS]-R
STRUCTURES  PDB: 1AL6  2CTS  1CSS  1CTS  6CSC  1AJ8  5CTS  1AMZ  1CSC  1CSH  
                 1CSI  1CSR  2CSC  6CTS  3CSC  3CTS  4CSC  4CTS  5CSC  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.7
            ExPASy - ENZYME nomenclature database: 4.1.3.7
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.7
            BRENDA, the Enzyme Database: 4.1.3.7
            SCOP (Structural Classification of Proteins): 4.1.3.7
///
ENTRY       EC 4.1.3.8
NAME        ATP citrate (pro-S)-lyase
            Citrate cleavage enzyme
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     ATP:citrate oxaloacetate-lyase ((pro-3S)-CH2COO- ->acetyl-CoA)
            (ATP-dephosphorylating)
REACTION    ATP + Citrate + CoA = ADP + Orthophosphate + Acetyl-CoA +
            Oxaloacetate
SUBSTRATE   ATP
            Citrate
            CoA
PRODUCT     ADP
            Orthophosphate
            Acetyl-CoA
            Oxaloacetate
COMMENT     The enzyme can be dissociated into components, two of which are
            identical with EC 4.1.3.34 and 6.2.1.18.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
GENES       SPO: SPAC22A12.16(spac22a12.16)
            CEL: B0365.1 D1005.1
            DME: CG8322(ATPCL)
            HSA: 47(ACLY)
DISEASE     MIM: 108728  ATP citrate lyase
MOTIF       PS: PS00399  G-x(2)-A-x(4,7)-[RQT]-[LIVMF]-G-H-[AS]-[GH]
            PS: PS01216  S-[KR]-S-G-[GT]-[LIVM]-[GST]-x-[EQ]-x(8,10)-G-x(4)-
                         [LIVM]-[GA]-[LIVM]-G-G-D
            PS: PS01217  G-x-[IV]-x(2)-[LIVMF]-x-[NA]-G-[GA]-G-[LMA]-[STAV]-
                         x(4)-D-x-[LIVM]-x(3)-G-[GREA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.8
            ExPASy - ENZYME nomenclature database: 4.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.8
            BRENDA, the Enzyme Database: 4.1.3.8
///
ENTRY       EC 4.1.3.9
NAME        2-Hydroxyglutarate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2-Hydroxyglutarate glyoxylate-lyase (CoA-propanoylating)
REACTION    2-Hydroxyglutarate + CoA = Propanoyl-CoA + H2O + Glyoxylate
SUBSTRATE   2-Hydroxyglutarate
            CoA
PRODUCT     Propanoyl-CoA
            H2O
            Glyoxylate
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.9
            ExPASy - ENZYME nomenclature database: 4.1.3.9
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.9
            BRENDA, the Enzyme Database: 4.1.3.9
///
ENTRY       EC 4.1.3.10
NAME        3-Ethylmalate synthase
            2-Ethyl-3-hydroxybutanedioate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Ethylmalate glyoxylate-lyase (CoA-butanoylating)
REACTION    3-Ethylmalate + CoA = Butanoyl-CoA + H2O + Glyoxylate
SUBSTRATE   3-Ethylmalate
            CoA
PRODUCT     Butanoyl-CoA
            H2O
            Glyoxylate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.10
            ExPASy - ENZYME nomenclature database: 4.1.3.10
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.10
            BRENDA, the Enzyme Database: 4.1.3.10
///
ENTRY       EC 4.1.3.11
NAME        3-Propylmalate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Propylmalate glyoxylate-lyase (CoA-pentanoylating)
REACTION    3-Propylmalate + CoA = Pentanoyl-CoA + H2O + Glyoxylate
SUBSTRATE   3-Propylmalate
            CoA
PRODUCT     Pentanoyl-CoA
            H2O
            Glyoxylate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.11
            ExPASy - ENZYME nomenclature database: 4.1.3.11
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.11
            BRENDA, the Enzyme Database: 4.1.3.11
///
ENTRY       EC 4.1.3.12
NAME        2-Isopropylmalate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-
            lyase (CoA-acetylating)
REACTION    3-Carboxy-3-hydroxy-4-methylpentanoate + CoA = Acetyl-CoA +
            3-Methyl-2-oxobutanoate + H2O
SUBSTRATE   3-Carboxy-3-hydroxy-4-methylpentanoate
            CoA
PRODUCT     Acetyl-CoA
            3-Methyl-2-oxobutanoate
            H2O
COFACTOR    K+
COMMENT     Requires K+.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0074(leuA)
            ECE: Z0083(leuA)
            ECS: ECs0078
            YPE: YPO0533(leuA)
            HIN: HI0986(leuA)
            PMU: PM1962(leuA)
            XFA: XF1818
            VCH: VC2490
            PAE: PA1217 PA3792(leuA)
            BUC: BUpL04(leuA)
            NME: NMB1070
            NMA: NMA1270(leuA)
            CJE: Cj1719c(leuA)
            MLO: mlr2792
            SME: SMc02546(leuA2) SMc02717(leuA1)
            CCR: CC1541
            BSU: BG11948(leuA)
            BHA: BH3058(leuA)
            SAU: SA1862(leuA)
            SAV: SAV2042(leuA)
            SPN: SP1258
            SPR: spr1136(leuA-truncation) spr1137(leuA-truncation)
            CAC: CAC0273 CAC3174(leuA)
            MTU: Rv3710(leuA)
            MTC: MT3813
            MLE: ML2324(leuA)
            SYN: sll1564(leuA) slr0186(leuA)
            DRA: DR1482
            AAE: aq_2090(leuA2) aq_356(leuA1)
            TMA: TM0552 TM0553
            MJA: MJ0503 MJ1195 MJ1392
            MTH: MTH1481 MTH1630 MTH723
            AFU: AF0219(leuA-2) AF0957(leuA-1)
            TVO: TVG0959514
            PHO: PH1727
            PAB: PAB0286(leuA-2) PAB0890(leuA-1) PAB0894(leuA-3)
            SSO: SSO0127(leuA-1) SSO2407(leuA-3)
            STO: ST0538
            SCE: YNL104C(LEU4)
            SPO: SPBC3E7.16C
MOTIF       PS: PS00815  L-R-[DE]-G-x-Q-x(10)-K
            PS: PS00816  [LIVMFW]-x(2)-H-x-H-[DN]-D-x-G-x-[GAS]-x-[GASLI]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.12
            ExPASy - ENZYME nomenclature database: 4.1.3.12
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.12
            BRENDA, the Enzyme Database: 4.1.3.12
///
ENTRY       EC 4.1.3.13
NAME        Oxalomalate lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Oxalomalate glyoxylate-lyase
REACTION    3-Oxalomalate = Oxaloacetate + Glyoxylate
SUBSTRATE   3-Oxalomalate
PRODUCT     Oxaloacetate
            Glyoxylate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.13
            ExPASy - ENZYME nomenclature database: 4.1.3.13
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.13
            BRENDA, the Enzyme Database: 4.1.3.13
///
ENTRY       EC 4.1.3.14
NAME        3-Hydroxyaspartate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     erythro-3-Hydroxy-L-aspartate glyoxylate-lyase
REACTION    erythro-3-Hydroxy-L-aspartate = Glycine + Glyoxylate
SUBSTRATE   erythro-3-Hydroxy-L-aspartate
PRODUCT     Glycine
            Glyoxylate
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.14
            ExPASy - ENZYME nomenclature database: 4.1.3.14
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.14
            BRENDA, the Enzyme Database: 4.1.3.14
///
ENTRY       EC 4.1.3.15
NAME        2-Hydroxy-3-oxoadipate synthase
            2-Hydroxy-3-oxoadipate synthetase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2-Hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating)
REACTION    2-Hydroxy-3-oxoadipate + CO2 = 2-Oxoglutarate + Glyoxylate
SUBSTRATE   2-Hydroxy-3-oxoadipate
            CO2
PRODUCT     2-Oxoglutarate
            Glyoxylate
COFACTOR    Thiamine diphosphate
COMMENT     The bacterial enzyme requires thiamine diphosphate. Reaction goes
            in the reverse direction; the product decarboxylates to 5-hydroxy-
            -4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate.
            Acetaldehyde can replace glyoxylate.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.15
            ExPASy - ENZYME nomenclature database: 4.1.3.15
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.15
            BRENDA, the Enzyme Database: 4.1.3.15
///
ENTRY       EC 4.1.3.16
NAME        4-Hydroxy-2-oxoglutarate aldolase
            2-Oxo-4-hydroxyglutarate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     4-Hydroxy-2-oxoglutarate glyoxylate-lyase
REACTION    4-Hydroxy-2-oxoglutarate = Pyruvate + Glyoxylate
SUBSTRATE   4-Hydroxy-2-oxoglutarate
PRODUCT     Pyruvate
            Glyoxylate
COMMENT     Acts on both stereoisomers. Previously listed also as EC 4.1.2.31.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b1850(eda)
            ECE: Z2902(eda)
            ECS: ECs2560
            YPE: YPO2067(eda)
            HIN: HI0047(eda)
            PMU: PM0947(eda)
            XFA: XF1061
            VCH: VC0285
            PAE: PA3131 PA3181
            NME: NMB1394
            NMA: NMA1611(eda)
            HPY: HP1099(eda)
            HPJ: jhp1025
            MLO: mlr2994
            SME: SMc02043(eda1) SMc03153(eda2)
            CCR: CC0784 CC1495
            BSU: BG11396(kdgA)
            BHA: BH3723(kdgA)
            LLA: L0022(kdgA)
            SPY: SPy0639(kgdA)
            SPN: SP0317
            SPR: spr0287(kdgA)
            CAC: CAC0394(kdgA) CAC2973(kdgA)
            TPA: TP0568
            SYN: sll0107(eda)
            TMA: TM0066
MOTIF       PS: PS00159  G-[LIVM]-x(3)-E-[LIV]-T-[LF]-R
            PS: PS00160  G-x(3)-[LIVMF]-K-[LF]-F-P-[SA]-x(3)-G
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.16
            ExPASy - ENZYME nomenclature database: 4.1.3.16
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.16
            BRENDA, the Enzyme Database: 4.1.3.16
///
ENTRY       EC 4.1.3.17
NAME        4-Hydroxy-4-methyl-2-oxoglutarate aldolase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     4-Hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase
REACTION    4-Hydroxy-4-methyl-2-oxoglutarate = 2 Pyruvate
SUBSTRATE   4-Hydroxy-4-methyl-2-oxoglutarate
            4-Hydroxy-4-methyl-2-oxoadipate
            4-Carboxy-4-hydroxy-2-oxoadipate
PRODUCT     Pyruvate
COMMENT     Also acts on 4-hydroxy-4-methyl-2-oxoadipate and 4-carboxy-4-
            -hydroxy-2-oxoadipate.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.17
            ExPASy - ENZYME nomenclature database: 4.1.3.17
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.17
            BRENDA, the Enzyme Database: 4.1.3.17
///
ENTRY       EC 4.1.3.18
NAME        Acetolactate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Acetolactate pyruvate-lyase (carboxylating)
REACTION    2-Acetolactate + CO2 = 2 Pyruvate
SUBSTRATE   2-Acetolactate
            CO2
            2-Oxobutanoate
            Pyruvate
PRODUCT     Pyruvate
            2-Aceto-2-hydroxybutanoate
            2-(alpha-Hydroxyethyl)thiamine diphosphate
INHIBITOR   Sulphometuron methyl
            Chlorsulfuron
            Imazaquin
            Ubiquinone-0
COFACTOR    FAD
            Thiamin diphosphate
COMMENT     A flavoprotein. Requires thiamine diphosphate; also catalyses the
            formation of 2-aceto-2-hydroxybutanoate. Reaction proceeds via
            2-(alpha-Hydroxyethyl)thiamine diphosphate. Inhibited by sulphonyl-
            -ureas and imidazolinones herbicides.  Sequence and functional
            similarity to pyruvate oxidase (EC 1.2.3.3); Nature, 1988, 331,
            360-362. Evolved from a common ancestor.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00650  Butanoate metabolism
            PATH: MAP00660  C5-Branched dibasic acid metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b0077(ilvI) b0078(ilvH) b3670(ilvN) b3671(ilvB) b3767(ilvG)
                 b3769(ilvM)
            ECE: Z0087(ilvI) Z0088(ilvH) Z5164(ilvN) Z5165(ilvB) Z5279(ilvG)
                 Z5280(ilvM)
            ECS: ECs0081 ECs0082 ECs4611 ECs4612 ECs4702 ECs4703
            YPE: YPO0539(ilvI) YPO0540(ilvH) YPO2293(ilvB) YPO2294(ilvN)
                 YPO3900(ilvM) YPO3901(ilvG)
            HIN: HI0737(ilvG) HI1584(ilvH) HI1585(ilvI)
            PMU: PM0869(ilvH) PM0870(ilvI) PM1627(ilvM) PM1628(ilvG)
            XFA: XF1820 XF1821
            VCH: VC0030 VC0031 VC1590 VC2482 VC2483
            PAE: PA4180 PA4695(ilvH) PA4696(ilvI)
            BUC: BU225(ilvH) BU226(ilvI)
            NME: NMB1576 NMB1577
            NMA: NMA1765(ilvH) NMA1766(ilvI)
            CJE: Cj0574(ilvI) Cj0575(ilvH)
            MLO: mll1432 mll1433 mll3567 mlr5207 mlr6648 mlr7164
            SME: SMa0958(atrC) SMa2211(ilvB2) SMb21530(ilvB2) SMc01430(ilvH)
                 SMc01431(ilvI) SMc02263(ilvB1) SMc04455(ilvG)
            CCR: CC2100 CC2101
            BSU: BG10471(alsS) BG10670(ilvB) BG10671(ilvN)
            BHA: BH3060(ilvN) BH3061 BH3873
            SAU: SA1859(ilvB) SA2008(alsS)
            SAV: SAV2039(ilvB) SAV2193(alsS)
            LLA: L0078(ilvB) L0079(ilvN) L210(als)
            SPN: SP0445 SP0446
            SPR: spr0401(ilvB) spr0402(ilvN)
            CAC: CAC3169(ilvB) CAC3176(ilvN) CAC3652(alsS)
            MTU: Rv1820(ilvG) Rv3002c(ilvN) Rv3003c(ilvB) Rv3470c(ilvB2)
                 Rv3509c(ilvX)
            MTC: MT1868 MT3082 MT3083 MT3576
            MLE: ML0354(ilvX) ML1695(ilvN) ML1696(ilvB) ML2083(ilvG)
            SYN: sll0065(ilvN) sll1981(ilvB) slr2088(ilvG)
            DRA: DR1516
            AAE: aq_1851(ilvH) aq_451(ilvB)
            TMA: TM0548 TM0549
            MJA: MJ0161(ilvN) MJ0277(ilvB) MJ0663
            MTH: MTH1443 MTH1444 MTH1602 MTH476
            AFU: AF1672 AF1719(ilvN) AF1720(ilvB-1) AF1780(ilvB-2)
                 AF2015(ilvB-3) AF2100(ilvB-4)
            TAC: Ta0691
            PAB: PAB0888(ilvB)
            APE: APE2509
            SSO: SSO0579(ilvB-2)
            SCE: YCL009C(ILV6) YMR108W(ILV2)
            SPO: ILV1(ilv1) SPBC14C8.04(spbc14c8.04)
            CEL: T26C12.1
            DME: CG11208
MOTIF       PS: PS00187  [LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-
                         [GSA]-[GSAC]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.18
            ExPASy - ENZYME nomenclature database: 4.1.3.18
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.18
            BRENDA, the Enzyme Database: 4.1.3.18
///
ENTRY       EC 4.1.3.19
NAME        N-Acetylneuraminate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     N-Acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating)
REACTION    N-Acetylneuraminate + Orthophosphate = N-Acetyl-D-mannosamine +
            Phosphoenolpyruvate + H2O
SUBSTRATE   N-Acetylneuraminate
            Orthophosphate
PRODUCT     N-Acetyl-D-mannosamine
            Phosphoenolpyruvate
            H2O
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.19
            ExPASy - ENZYME nomenclature database: 4.1.3.19
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.19
            BRENDA, the Enzyme Database: 4.1.3.19
///
ENTRY       EC 4.1.3.20
NAME        N-Acylneuraminate-9-phosphate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     N-Acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-
            $phosphorylating)
REACTION    N-Acylneuraminate 9-phosphate + Orthophosphate =
            N-Acyl-D-mannosamine 6-phosphate + Phosphoenolpyruvate + H2O
SUBSTRATE   N-Acylneuraminate 9-phosphate
            Orthophosphate
PRODUCT     N-Acyl-D-mannosamine 6-phosphate
            Phosphoenolpyruvate
            H2O
COMMENT     Acts on N-glycoloyl and N-acetyl-derivatives.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.20
            ExPASy - ENZYME nomenclature database: 4.1.3.20
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.20
            BRENDA, the Enzyme Database: 4.1.3.20
///
ENTRY       EC 4.1.3.21
NAME        Homocitrate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2-Hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase
            (CoA-acetylating)
REACTION    2-Hydroxybutane-1,2,4-tricarboxylate + CoA =
            Acetyl-CoA + H2O + 2-Oxoglutarate
SUBSTRATE   2-Hydroxybutane-1,2,4-tricarboxylate
            CoA
PRODUCT     Acetyl-CoA
            H2O
            2-Oxoglutarate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00620  Pyruvate metabolism
GENES       DRA: DR1238
            SCE: YDL131W(LYS21) YDL182W(LYS20)
            SPO: SPBC1105.02C(spbc1105.02c)
MOTIF       PS: PS00815  L-R-[DE]-G-x-Q-x(10)-K
            PS: PS00816  [LIVMFW]-x(2)-H-x-H-[DN]-D-x-G-x-[GAS]-x-[GASLI]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.21
            ExPASy - ENZYME nomenclature database: 4.1.3.21
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.21
            BRENDA, the Enzyme Database: 4.1.3.21
///
ENTRY       EC 4.1.3.22
NAME        Citramalate lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (3S)-Citramalate pyruvate-lyas
REACTION    Citramalate = Acetate + Pyruvate
SUBSTRATE   Citramalate
PRODUCT     Acetate
            Pyruvate
COMMENT     This enzyme can be dissociated into components, two of which are
            identical with EC 2.8.3.11 and 4.1.3.25.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.22
            ExPASy - ENZYME nomenclature database: 4.1.3.22
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.22
            BRENDA, the Enzyme Database: 4.1.3.22
///
ENTRY       EC 4.1.3.23
NAME        Decylcitrate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (2A,3S)-2-Hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase
            $ (CoA-acylating)
REACTION    (2A,3S)-2-Hydroxytridecane-1,2,3-tricarboxylate + CoA =
            Lauroyl-CoA + H2O + Oxaloacetate
SUBSTRATE   (2A,3S)-2-Hydroxytridecane-1,2,3-tricarboxylate
            CoA
PRODUCT     Lauroyl-CoA
            H2O
            Oxaloacetate
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.23
            ExPASy - ENZYME nomenclature database: 4.1.3.23
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.23
            BRENDA, the Enzyme Database: 4.1.3.23
///
ENTRY       EC 4.1.3.24
NAME        Malyl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (3S)-3-Carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase
REACTION    (3S)-3-Carboxy-3-hydroxypropanoyl-CoA = Acetyl-CoA + Glyoxylate
SUBSTRATE   (3S)-3-Carboxy-3-hydroxypropanoyl-CoA
PRODUCT     Acetyl-CoA
            Glyoxylate
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.24
            ExPASy - ENZYME nomenclature database: 4.1.3.24
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.24
            BRENDA, the Enzyme Database: 4.1.3.24
///
ENTRY       EC 4.1.3.25
NAME        Citramalyl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (3S)-Citramalyl-CoA pyruvate-lyase
REACTION    (3S)-Citramalyl-CoA  = Acetyl-CoA + Pyruvate
SUBSTRATE   (3S)-Citramalyl-CoA
PRODUCT     Acetyl-CoA
            Pyruvate
COMMENT     This enzyme is a component of EC 4.1.3.22. Also acts on
            (3S)-citramalyl thioacyl-carrier protein.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.25
            ExPASy - ENZYME nomenclature database: 4.1.3.25
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.25
            BRENDA, the Enzyme Database: 4.1.3.25
///
ENTRY       EC 4.1.3.26
NAME        3-Hydroxy-3-isohexenylglutaryl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Hydroxy3-isohexenylglutaryl-CoA isopenenylacetoacetyl-CoA-
            $lyase
REACTION    3-Hydroxy-3-(4-methylpent-3-en-1-yl)-glutaryl-CoA =
            7-Methyl-3-oxooctanoyl-CoA + Acetate
SUBSTRATE   3-Hydroxy-3-(4-methylpent-3-en-1-yl)-glutaryl-CoA
PRODUCT     7-Methyl-3-oxooctanoyl-CoA
            Acetate
COMMENT     Also acts on the hydroxy derivative of farnesoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.26
            ExPASy - ENZYME nomenclature database: 4.1.3.26
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.26
            BRENDA, the Enzyme Database: 4.1.3.26
///
ENTRY       EC 4.1.3.27
NAME        Anthranilate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Chorismate pyruvate-lyase (amino-accepting)
REACTION    Chorismate + L-Glutamine = Anthranilate + Pyruvate + L-Glutamate
SUBSTRATE   Chorismate
            L-Glutamine
            NH3
PRODUCT     Anthranilate
            Pyruvate
            L-Glutamate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein together with one or more other components of the system
            for biosymthesis of tryptophan (EC 2.4.2.18, 4.1.1.48, 4.2.1.20,
            5.3.1.24). The native enzyme in the complex uses either glutamine
            or, less efficiently, NH3. The enzyme separated from the complex
            uses NH3 only.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1263(trpD) b1264(trpE)
            ECE: Z2546(trpE_1) Z2547(trpE_2) Z2548(trpD)
            ECS: ECs1835 ECs1836
            YPE: YPO2207(trpG) YPO2208(trpE)
            HIN: HI1171(trpG) HI1387(trpE) HI1388(trpD)
            PMU: PM0583(trpG_1) PM0584(trpE) PM1463(trpG_2)
            XFA: XF0210 XF0211 XF0674 XF1914 XF1915
            VCH: VC1173 VC1174
            PAE: PA0609(trpE) PA0649(trpG) PA1001(phnA) PA1002(phnB)
            BUC: BUpT01(trpE) BUpT02(trpG) BUpT03(trpE2) BUpT04(trpG2)
            NME: NMB0966 NMB1021
            NMA: NMA1163(trpG) NMA1247(trpE)
            HPY: HP1281(trpD) HP1282(trpE)
            HPJ: jhp1202 jhp1203
            CJE: Cj0345(trpE) Cj0346(trpD)
            MLO: mlr2774
            SME: SMc02725(trpE)
            CCR: CC1895 CC1897
            BSU: BG10287(trpE)
            BHA: BH1659(trpE)
            SAU: SA0668 SA1199 SA1200(trpG)
            SAV: SAV0700 SAV1352(trpE) SAV1353(trpG)
            LLA: L0053(trpG) L0054(trpE)
            SPY: SPy1991(trpG)
            SPN: SP1816 SP1817
            SPR: spr1636(trpG) spr1637(trpE)
            CAC: CAC3162(pabA) CAC3163(parB)
            MTU: Rv1609(trpE) Rv2386c(trpE2)
            MTC: MT1644
            MLE: ML1269(trpE)
            SYN: slr0055(trpG) slr0738(trpE) slr1979(trpE)
            DRA: DR0196 DR1766 DR1791
            AAE: aq_549(trpG) aq_582(trpE)
            TMA: TM0141 TM0142
            MJA: MJ0238(trpG) MJ1075(trpE)
            MTH: MTH1655(trpE) MTH1656(trpG)
            AFU: AF1602(trpG) AF1603(trpE)
            HAL: VNG1646G(trpG1) VNG1647G(trpE1)
            TAC: Ta0806 Ta0807
            TVO: TVG1078652 TVG1079200
            PAB: PAB2045(trpE) PAB2046(trpG)
            APE: APE2553 APE2555
            SSO: SSO0893(trpE) SSO0894(trpGD)
            STO: ST1228 ST1229
            SCE: YER090W(TRP2) YKL211C(TRP3)
            SPO: SPCC1442.09(spcc1442.09) TRP1(trp1)
            ATH: At2g29690(T27A16.21)
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00614  [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[STAHKR]-S-P-
                         [ST]-x(3)-[LIVMFYST]
STRUCTURES  PDB: 1CSM  1I7S  1I1Q  1I7Q  1QDL  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.27
            ExPASy - ENZYME nomenclature database: 4.1.3.27
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.27
            BRENDA, the Enzyme Database: 4.1.3.27
            SCOP (Structural Classification of Proteins): 4.1.3.27
///
ENTRY       EC 4.1.3.28
NAME        Citrate (re)-synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     Citrate oxaloacetate-lyase ((pro-3R)-CH2COO- -->acetyl-CoA)
REACTION    Citrate + CoA = Acetyl-CoA + H2O + Oxaloacetate
SUBSTRATE   Citrate
            CoA
PRODUCT     Acetyl-CoA
            H2O
            Oxaloacetate
COMMENT     The stereospecificity of this enzyme is opposite to that of
            EC 4.1.3.7.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.28
            ExPASy - ENZYME nomenclature database: 4.1.3.28
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.28
            BRENDA, the Enzyme Database: 4.1.3.28
///
ENTRY       EC 4.1.3.29
NAME        Decylhomocitrate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     3-Hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase
            $(CoA-acylating)
REACTION    3-Hydroxytetradecane-1,3,4-tricarboxylate + CoA = Dodecanoyl-CoA +
            H2O + 2-Oxoglutarate
SUBSTRATE   3-Hydroxytetradecane-1,3,4-tricarboxylate
            CoA
PRODUCT     Dodecanoyl-CoA
            H2O
            2-Oxoglutarate
COMMENT     In the reverse reaction decanoyl-CoA can act instead of
            dodecanoyl-CoA but 2-oxoglutarate cannot be replaced by
            oxaloacetate or pyruvate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.29
            ExPASy - ENZYME nomenclature database: 4.1.3.29
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.29
            BRENDA, the Enzyme Database: 4.1.3.29
///
ENTRY       EC 4.1.3.30
NAME        Methylisocitrate lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
REACTION    (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate = Pyruvate +
            Succinate
SUBSTRATE   (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
PRODUCT     Pyruvate
            Succinate
COMMENT     This enzyme acts on threo-Ds-2-methylisocitrate but not on
            threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate.
PATHWAY     PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.30
            ExPASy - ENZYME nomenclature database: 4.1.3.30
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.30
            BRENDA, the Enzyme Database: 4.1.3.30
///
ENTRY       EC 4.1.3.31
NAME        2-Methylcitrate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2-Methylcitrate oxaloacetate-lyase
REACTION    2-Methylcitrate + CoA = Propanoyl-CoA + H2O + Oxaloacetate
SUBSTRATE   2-Methylcitrate
            CoA
PRODUCT     Propanoyl-CoA
            H2O
            Oxaloacetate
COMMENT     The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and
            petanoyl-CoA. The relative rate of condensation of acetyl-CoA and
            oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate but
            the enzyme has been separated from EC 4.1.3.7.  Oxaloacetate
            cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
PATHWAY     PATH: MAP00640  Propanoate metabolism
GENES       ECO: b0333(prpC)
            ECE: Z0428(prpC)
            ECS: ECs0386
            VCH: VC1337
            PAE: PA0795(prpC)
            NME: NMB0431
            NMA: NMA2054(prpC)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.31
            ExPASy - ENZYME nomenclature database: 4.1.3.31
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.31
            BRENDA, the Enzyme Database: 4.1.3.31
///
ENTRY       EC 4.1.3.32
NAME        2,3-Dimethylmalate lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     2,3-Dimethylmalate pyruvate-lyase
REACTION    2,3-Dimethylmalate = Propanoate + Pyruvate
SUBSTRATE   2,3-Dimethylmalate
PRODUCT     Propanoate
            Pyruvate
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.32
            ExPASy - ENZYME nomenclature database: 4.1.3.32
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.32
            BRENDA, the Enzyme Database: 4.1.3.32
///
ENTRY       EC 4.1.3.33
NAME        2-Ethylmalate synthase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (R)-2-Ethylmalate 2-oxobutanoyl-lyase (CoA-acylating)
REACTION    (R)-2-Ethylmalate + CoA = Acetyl-CoA + H2O + 2-Oxobutanoate
SUBSTRATE   (R)-2-Ethylmalate
            CoA
            (R)-2-(n-Propyl)-malate
PRODUCT     Acetyl-CoA
            H2O
            2-Oxobutanoate
COMMENT     Also acts on (R)-2-(n-propyl)-malate. Formerly wrongly included
            with EC 4.1.3.10.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.33
            ExPASy - ENZYME nomenclature database: 4.1.3.33
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.33
            BRENDA, the Enzyme Database: 4.1.3.33
///
ENTRY       EC 4.1.3.34
NAME        Citryl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (3S)-Citryl-CoA oxaloacetate-lyase
REACTION    (3S)-Citryl-CoA = Acetyl-CoA + Oxaloacetate
SUBSTRATE   (3S)-Citryl-CoA
PRODUCT     Acetyl-CoA
            Oxaloacetate
COMMENT     The enzyme is a component of EC 4.1.3.6 and 4.1.3.8. Also acts on
            (3S)-citryl thioacyl-carrier protein.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
GENES       ECO: b0616(citE)
            ECE: Z0760(citE)
            ECS: ECs0655
            HIN: HI0023(citE)
            VCH: VC0798
            SME: SMc03793(citE)
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.34
            ExPASy - ENZYME nomenclature database: 4.1.3.34
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.34
            BRENDA, the Enzyme Database: 4.1.3.34
///
ENTRY       EC 4.1.3.35
NAME        (1-Hydroxycyclohexan-1-yl)acetyl-CoA lyase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     (1-Hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase
REACTION    (1-Hydroxycyclohexan-1-yl)acetyl-CoA = Acetyl-CoA + Cyclohexanone
SUBSTRATE   (1-Hydroxycyclohexan-1-yl)acetyl-CoA
PRODUCT     Acetyl-CoA
            Cyclohexanone
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.35
            ExPASy - ENZYME nomenclature database: 4.1.3.35
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.35
            BRENDA, the Enzyme Database: 4.1.3.35
///
ENTRY       EC 4.1.3.36
NAME        Naphthoate synthase
            Dihydroxynaphthoic acid synthetase
            Dhna synthetase
CLASS       Lyases
            Carbon-carbon lyases
            Oxo-acid-lyases
SYSNAME     O-Succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase
REACTION    O-Succinylbenzoyl-CoA = 1,4-Dihydroxy-2-naphthoate + CoA
SUBSTRATE   O-Succinylbenzoyl-CoA
PRODUCT     1,4-Dihydroxy-2-naphthoate
            CoA
COMMENT     Highly specific.
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b2262(menB)
            ECE: Z3522(menB)
            ECS: ECs3150
            YPE: YPO2525(menB)
            HIN: HI0968(menB)
            PMU: PM1096(menB)
            VCH: VC1973
            BSU: BG10686(menB)
            SAU: SA0898(menB)
            SAV: SAV1032(memB)
            LLA: L0171(menB)
            MTU: Rv0548c(menB)
            MTC: MT0573
            MLE: ML2263(menB)
            SYN: sll1127(menB)
            AFU: AF1191(menB)
            HAL: VNG1079G(menB)
MOTIF       PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.3.36
            ExPASy - ENZYME nomenclature database: 4.1.3.36
            WIT (What Is There) Metabolic Reconstruction: 4.1.3.36
            BRENDA, the Enzyme Database: 4.1.3.36
///
ENTRY       EC 4.1.99.1
NAME        Tryptophanase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     L-Tryotophan indole-lyase (deaminating)
REACTION    L-Tryptophan + H2O = Indole + Pyruvate + NH3
SUBSTRATE   L-Tryptophan
            H2O
PRODUCT     Indole
            Pyruvate
            NH3
COFACTOR    Pyridoxal phosphate
            K+
COMMENT     A pyridoxal-phosphate protein, requiring K+. Also catalyses
            2,3-elimination and beta-replacement reactions of some indole-
            substituted tryptophan analogs of L-cysteine, L-serine and other
            3-substituted amino acids.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b3708(tnaA)
            ECE: Z5203(tnaA)
            ECS: ECs4645
            PMU: PM0811 PM1420(tnaA)
            VCH: VCA0161
            HAL: VNG2373G(tnaA)
            APE: APE1275
MOTIF       PS: PS00853  Y-x-D-x(3)-M-S-[GA]-K-K-D-x-[LIVM](2)-x-[LIVM]-G-G
STRUCTURES  PDB: 1AX4  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.1
            ExPASy - ENZYME nomenclature database: 4.1.99.1
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.1
            BRENDA, the Enzyme Database: 4.1.99.1
            SCOP (Structural Classification of Proteins): 4.1.99.1
///
ENTRY       EC 4.1.99.2
NAME        Tyrosine phenol-lyase
            beta-Tyrosinase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     L-Tyrosine phenol-lyase (deaminating)
REACTION    L-Tyrosine + H2O = Phenol + Pyruvate + NH3
SUBSTRATE   L-Tyrosine
            H2O
PRODUCT     Phenol
            Pyruvate
            NH3
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal phosphate protein. The enzyme also slowly catalyses
            pyruvate formation from D-tyrosine, S-methyl-L-cysteine,
            L-cysteine, L-serine and D-serine.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00910  Nitrogen metabolism
MOTIF       PS: PS00853  Y-x-D-x(3)-M-S-[GA]-K-K-D-x-[LIVM](2)-x-[LIVM]-G-G
STRUCTURES  PDB: 1TPL  2TPL  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.2
            ExPASy - ENZYME nomenclature database: 4.1.99.2
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.2
            BRENDA, the Enzyme Database: 4.1.99.2
            SCOP (Structural Classification of Proteins): 4.1.99.2
///
ENTRY       EC 4.1.99.3
NAME        Deoxyribodipyrimidine photo-lyase
            Photoreactivating enzyme
            DNA photolyase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     Deoxyribocyclobutadipyrimidine pyrimidine-lyase
REACTION    Cyclobutadipyrimidine (in DNA) = 2 Pyrimidine (in DNA)
SUBSTRATE   Cyclobutadipyrimidine
PRODUCT     Pyrimidine
COFACTOR    FAD
COMMENT     A Flavoprotein (FAD), containing a second chromophore group. The
            enzyme catalyses the reactivation by light of irradiated DNA. A
            similar reactivation of irradiated RNA is probably due to a
            separate enzyme.
GENES       ECO: b0708(phrB)
            ECE: Z0859(phrB)
            ECS: ECs0733
            YPE: YPO2695(phrB)
            VCH: VCA0057
            PAE: PA4660(phr)
            BUC: BU300(phrB)
            NMA: NMA2198(phr)
            MLO: mll8094
            CCR: CC1428
            SAU: SA0646
            SAV: SAV0678
            SPY: SPy1505(phr)
            SYN: sll1629(phr) slr0854(phr)
            MTH: MTH904
            HAL: VNG1335G(phr2)
            SSO: SSO2472(phrB)
            STO: ST0889
            SCE: YOR386W(PHR1)
            DME: CG11205(phr)
MOTIF       PS: PS00394  T-G-x-P-[LIVM](2)-D-A-x-M-[RA]-x-[LIVM]
            PS: PS00691  [DN]-R-x-R-[LIVM](2)-x-[STA](2)-F-[LIVMFA]-x-K-x-L-
                         x(2,3)-W-[KRQ]
            PS: PS01083  F-x-E-E-x-[LIVM](2)-R-R-E-L-x(2)-N-F
            PS: PS01084  G-x-H-D-x(2)-W-x-E-R-x-[LIVM]-F-G-K-[LIVM]-R-[FY]-M-N
STRUCTURES  PDB: 1DNP  1QNF  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.3
            ExPASy - ENZYME nomenclature database: 4.1.99.3
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.3
            BRENDA, the Enzyme Database: 4.1.99.3
            SCOP (Structural Classification of Proteins): 4.1.99.3
///
ENTRY       EC 4.1.99.4
NAME        1-Aminocyclopropane-1-carboxylate deaminase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     1-Aminocyclopropane-1-carboxylate endolyase (deaminating)
REACTION    1-Aminocyclopropane-1-carboxylate + H2O = 2-Oxobutanoate + NH3
SUBSTRATE   1-Aminocyclopropane-1-carboxylate
            H2O
PRODUCT     2-Oxobutanoate
            NH3
COFACTOR    Pyridoxal phosphate
PATHWAY     PATH: MAP00640  Propanoate metabolism
GENES       ECO: b1919(yedO)
            ECE: Z3008(yedO)
            ECS: ECs2657 ECs2658
            YPE: YPO1845(YedO)
            MLO: mlr5932
            CCR: CC2032
            TMA: TM0225
            PHO: PH0054
            PAB: PAB2303
            SPO: SPAC922.03(spac922.03)
STRUCTURES  PDB: 1F2D  
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.4
            ExPASy - ENZYME nomenclature database: 4.1.99.4
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.4
            UM-BBD (Biocatalysis/Biodegradation Database): 4.1.99.4
            BRENDA, the Enzyme Database: 4.1.99.4
            SCOP (Structural Classification of Proteins): 4.1.99.4
///
ENTRY       EC 4.1.99.5
NAME        Octadecanal decarbonylase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     Octadecanal alkane-lyase
REACTION    Octadecanal = Heptadecane + CO
SUBSTRATE   Octadecanal
PRODUCT     Heptadecane
            CO
INHIBITOR   Metal chelating agent
COMMENT     Involved in the biosynthesis of alkanes in Pisum sativum from
            fatty acids of chain length C18 to C32. Inhibited by metal
            chelating agents.
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.5
            ExPASy - ENZYME nomenclature database: 4.1.99.5
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.5
            BRENDA, the Enzyme Database: 4.1.99.5
///
ENTRY       EC 4.1.99.6
NAME        Trichodiene synthase
            Sesquiterpene cyclase
CLASS       Lyases
            Carbon-carbon lyases
            Other carbon-carbon lyases
SYSNAME     trans,trans-Farnesyl-diphosphate sesquiterpenoid-lyase
REACTION    trans,trans-Farnesyl diphosphate = Trichodiene + Pyrophosphate
SUBSTRATE   trans,trans-Farnesyl diphosphate
PRODUCT     Trichodiene
            Pyrophosphate
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.1.99.6
            ExPASy - ENZYME nomenclature database: 4.1.99.6
            WIT (What Is There) Metabolic Reconstruction: 4.1.99.6
            BRENDA, the Enzyme Database: 4.1.99.6
///
ENTRY       EC 4.2.1.1
NAME        Carbonate dehydratase
            Carbonic anhydrase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Carbonate hydro-lyase
REACTION    H2CO3 = CO2 + H2O
SUBSTRATE   H2CO3
PRODUCT     CO2
            H2O
COFACTOR    Zinc
COMMENT     A zinc protein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0126(yadF) b0339(cynT)
            ECE: Z0137(yadF) Z0435(cynT)
            ECS: ECs0130 ECs0392
            HIN: HI1301
            PMU: PM0575 PM1905
            XFA: XF0880
            VCH: VC0586 VCA0274
            PAE: PA0102 PA2053(cynT) PA4676
            HPY: HP0004(icfA) HP1186
            HPJ: jhp0004 jhp1112
            CJE: Cj0237(cynT)
            MLO: mll6384 mlr4135
            SME: SMa0045(cah) SMc04083(cynT)
            CCR: CC3569
            BHA: BH0360(cah)
            CAC: CAC2482
            MTU: Rv3588c
            MTC: MT3694
            MLE: ML1919
            SYN: slr0051(icfA) slr1347(icfA)
            DRA: DR2238
            MTH: MTH1582
            HAL: VNG0841G(icfA)
            SPO: SPBP8B7.05C(spbp8b7.05c)
            ATH: At3g01500(F4P13.5)
            CEL: D1022.8 F54D8.4 K05G3.3 R01E6.3 R173.1 T13C5.5 T28F2.3
            DME: CG11284 CG11967 CG12309 CG3669 CG3940 CG5379 CG6074 CG6906
                 CG7820(CAH1) CG9235
            MMU: 101946(Car5) 88253(Cals) 88268(Car1) 88269(Car2) 88270(Car3)
            HSA: 11238(CA5B) 23632(CA14) 759(CA1) 760(CA2) 761(CA3) 762(CA4)
                 763(CA5A) 765(CA6) 766(CA7) 767(CA8) 768(CA9) 770(CA11)
                 771(CA12)
DISEASE     MIM: 114750  Carbonic anhydrase III
            MIM: 114760  Carbonic anhydrase IV
            MIM: 114761  Carbonic anhydrase V (mitochondrial)
            MIM: 114770  Carbonic anhydrase VII
            MIM: 114780  Carbonic anhydrase VI
            MIM: 114800  Carbonic anhydrase I
            MIM: 114815  Carbonic anhydrase VIII
            MIM: 259730  Carbonic anhydrase II
            MIM: 300230  Carbonic anhydrase VB, mitochondrial
            MIM: 603179  Carbonic anhydrase IX
            MIM: 603263  Carbonic anhydrase XII
            MIM: 604832  Carbonic anhydrase XIV
MOTIF       PS: PS00162  S-E-[HN]-x-[LIVM]-x(4)-[FYH]-x(2)-E-[LIVMGA]-H-
                         [LIVMFA](2)
            PS: PS00704  C-[SA]-D-S-R-[LIVM]-x-[AP]
            PS: PS00705  [EQ]-Y-A-[LIVM]-x(2)-[LIVM]-x(4)-[LIVMF](3)-x-G-H-x(2)-
                         C-G
STRUCTURES  PDB: 12CA  1A42  1AM6  1AVN  1AZM  1BCD  1BIC  1BN1  1BN3  1BN4  
                 1BNM  1BNN  1BNQ  1BNT  1BNU  1BNV  1BNW  1BV3  1BZM  1CA2  
                 1CA3  1CAH  1CAI  1CAJ  1CAK  1CAL  1CAM  1CAN  1CAO  1CAY  
                 1CAZ  1CCS  1CCT  1CCU  1CIL  1CIM  1CIN  1CNB  1CNC  1CNG  
                 1CNH  1CNI  1CNJ  1CNK  1CNW  1CNX  1CNY  1CRA  1CRM  1CVA  
                 1CVB  1CVC  1CVD  1CVE  1CVF  1CVH  1CZM  1DCA  1DCB  1DDZ  
                 1DMX  1DMY  1EKJ  1F2W  1FLJ  1FQL  1FQM  1FQN  1FQR  1FR4  
                 1FR7  1FSN  1FSQ  1FSR  1G0E  1G0F  1G1D  1G3Z  1G45  1G46  
                 1G48  1G4J  1G4O  1G52  1G53  1G54  1G5C  1G6V  1H4N  1H9N  
                 1H9Q  1HCA  1HCB  1HEA  1HEB  1HEC  1HED  1HUG  1HUH  1HVA  
                 1I6O  1I6P  1I8Z  1I90  1I91  1I9L  1I9M  1I9N  1I9O  1I9P  
                 1I9Q  1IF4  1IF5  1IF6  1IF7  1IF8  1IF9  1J9W  1JCZ  1JD0  
                 1JV0  1KOP  1KOQ  1MUA  1OKL  1OKM  1OKN  1RAY  1RAZ  1RZA  
                 1RZB  1RZC  1RZD  1RZE  1THJ  1UGA  1UGB  1UGC  1UGD  1UGE  
                 1UGF  1UGG  1URT  1YDA  1YDB  1YDC  1YDD  1ZNC  1ZSA  1ZSB  
                 1ZSC  2CA2  2CAB  2CBA  2CBB  2CBC  2CBD  2CBE  2H4N  2ZNC  
                 3CA2  3ZNC  4CA2  4CAC  5CA2  5CAC  6CA2  7CA2  8CA2  9CA2  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.1
            ExPASy - ENZYME nomenclature database: 4.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.1
            BRENDA, the Enzyme Database: 4.2.1.1
            SCOP (Structural Classification of Proteins): 4.2.1.1
///
ENTRY       EC 4.2.1.2
NAME        Fumarate hydratase
            Fumarase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (S)-Malate hydro-lyase
REACTION    (S)-Malate = Fumarate + H2O
SUBSTRATE   (S)-Malate
PRODUCT     Fumarate
            H2O
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b1611(fumC) b1612(fumA) b4122(fumB)
            ECE: Z0887 Z2614(fumC) Z2615(fumA) Z5724(fumB)
            ECS: ECs0757 ECs2317 ECs2318 ECs5104
            YPE: YPO2264(fumC) YPO3335(fumA)
            HIN: HI1398(fumC)
            PMU: PM0823(fumC)
            XFA: XF1554 XF1855
            VCH: VC1304 VC1573
            PAE: PA0854(fumC2) PA4333 PA4470(fumC1)
            NME: NMB1458 NMB1613
            NMA: NMA1670(fumC) NMA1812(fumA)
            HPY: HP1325(fumC)
            HPJ: jhp1245
            CJE: Cj1364c(fumC)
            RPR: RP665(fumC)
            RCO: RC1012(fumC)
            MLO: mll8172 mlr6099
            SME: SMc00149(fumC)
            CCR: CC2109
            BSU: BG10384(citG)
            BHA: BH0894 BH1445(citB)
            SAU: SA1669(citG)
            SAV: SAV1835(citG)
            CAC: CAC3090 CAC3091
            MTU: Rv1098c(fum)
            MTC: MT1130
            MLE: ML1947(fum)
            CTR: CT855
            CMU: TC0244
            CPN: CPn1013
            CPA: CP0840
            CPJ: fumC
            SYN: slr0018(fumC)
            DRA: DR2627
            AAE: aq_1679(fumX) aq_1780(fumB)
            TMA: TM0540 TM0541
            MJA: MJ0617 MJ1294
            MTH: MTH1115 MTH1735 MTH1910 MTH963
            AFU: AF1098(fum-1) AF1099(fum-2)
            HAL: VNG1356G(fumC)
            TAC: Ta0258
            TVO: TVG1409429
            PHO: PH1683 PH1684
            PAB: PAB2030(fum-1) PAB2031(fum-2)
            APE: APE1816
            SSO: SSO1077
            SCE: YPL262W(FUM1)
            SPO: SPCC18.18C(spcc18.18c)
            ATH: At2g47510(T30B22.15)
            CEL: H14A12.2
            DME: CG4095 CG6140
            HSA: 2271
DISEASE     MIM: 136850  Fumarate hydratase
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
STRUCTURES  PDB: 2FUS  1YFM  1FUR  1FUQ  1FUP  1FUO  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.2
            ExPASy - ENZYME nomenclature database: 4.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.2
            BRENDA, the Enzyme Database: 4.2.1.2
            SCOP (Structural Classification of Proteins): 4.2.1.2
///
ENTRY       EC 4.2.1.3
NAME        Aconitate hydratase
            Aconitase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Citrate(isocitrate) hydro-lyase
REACTION    Citrate = Isocitrate
SUBSTRATE   Citrate
            cis-Aconitate
            H2O
            Isocitrate
PRODUCT     cis-Aconitate
            H2O
COFACTOR    Iron
            Sulfur
COMMENT     An iron-sulfur protein. cis-Aconitate is used to designate the
            isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. Also converts
            isocitrate into cis-aconitate.
            (Proc.Natl.Acad.Sci.USA (1991) 88, 10109-10113)
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b0118(acnB) b1276(acnA)
            ECE: Z0128(acnB) Z2532(acnA)
            ECS: ECs0122 ECs1849
            YPE: YPO2221(acnA) YPO3415(acnB)
            PMU: PM0204(acnB)
            XFA: XF0290 XF0292
            VCH: VC0604 VC1338
            PAE: PA0794 PA1562(acnA) PA1787(acnB)
            NME: NMB0433 NMB1572
            NMA: NMA1761(acnB) NMA2052(acnA)
            HPY: HP0779(acnB)
            HPJ: jhp0716
            CJE: Cj0835c(acnB)
            RPR: RP799(acnA)
            RCO: RC1233(acnA)
            MLO: mlr4335
            SME: SMc03846(acnA)
            CCR: CC3667
            BSU: BG10478(citB)
            BHA: BH2299(citB)
            SAU: SA1184(citB)
            SAV: SAV1335(citB)
            LLA: L68478(citB)
            CAC: CAC0971(citB)
            MTU: Rv1475c(acn)
            MTC: MT1522
            MLE: ML1814(acn)
            SYN: slr0665(acnB)
            DRA: DR1720
            AAE: aq_1784(aco)
            HAL: VNG2574G(can)
            TAC: Ta0112
            TVO: TVG0196114
            APE: APE1618
            SSO: SSO1095
            STO: ST0833
            SCE: YJL200C YLR304C(ACO1)
            SPO: SPAC24C9.06C(spac24c9.06c)
            ATH: At2g05710(T3P4.5)
            CEL: F54H12.1 ZK455.1
            DME: CG4706 CG4900(Irp-1A) CG6342(Irp-1B) CG9244(Acon)
            MMU: 87879(Aco1)
            HSA: 48(ACO1) 50(ACO2)
DISEASE     MIM: 100850  Aconitase, mitochondrial
            MIM: 100880  Aconitase, soluble
MOTIF       PS: PS00450  [LIVM]-x(2)-[GSACIVM]-x-[LIV]-[GTIV]-[STP]-C-x(0,1)-T-
                         N-[GSTANI]-x(4)-[LIVMA]
            PS: PS01244  G-x(2)-[LIVWPQ]-x(3)-[GAC]-C-[GSTAM]-[LIMPTA]-C-[LIMV]-
                         [GA]
STRUCTURES  PDB: 1NIS  1FGH  8ACN  7ACN  6ACN  5ACN  1NIT  1ACO  1AMI  1C97  
                 1C96  1B0M  1B0K  1B0J  1AMJ  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.3
            ExPASy - ENZYME nomenclature database: 4.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.3
            BRENDA, the Enzyme Database: 4.2.1.3
            SCOP (Structural Classification of Proteins): 4.2.1.3
///
ENTRY       EC 4.2.1.4
NAME        Citrate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Citrate hydro-lyase
REACTION    Citrate = cis-Aconitate + H2O
SUBSTRATE   Citrate
PRODUCT     cis-Aconitate
            H2O
COMMENT     cis-Acnonitate is used to designate the isomer (Z)-prop-1-ene-
            -1,2,3-tricarboxylate. Does not act on isocitrate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.4
            ExPASy - ENZYME nomenclature database: 4.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.4
            BRENDA, the Enzyme Database: 4.2.1.4
///
ENTRY       EC 4.2.1.5
NAME        Arabinonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Arabinonate hydro-lyase
REACTION    D-Arabinonate = 2-Dehydro-3-deoxy-D-arabinonate + H2O
SUBSTRATE   D-Arabinonate
PRODUCT     2-Dehydro-3-deoxy-D-arabinonate
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.5
            ExPASy - ENZYME nomenclature database: 4.2.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.5
            BRENDA, the Enzyme Database: 4.2.1.5
///
ENTRY       EC 4.2.1.6
NAME        Galactonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Galactonate hydro-lyase
REACTION    D-Galactonate = 2-Dehydro-3-deoxy-D-galactonate + H2O
SUBSTRATE   D-Galactonate
PRODUCT     2-Dehydro-3-deoxy-D-galactonate
            H2O
COMMENT     Functional similarity to mandelate racemase (EC 5.1.2.2) and
            muconate cycloisomerase (EC 5.5.1.1); Biochemistry, 1990,
            29, 9856-9862; Nature, 1990, 347, 692-694. They abstract the
            alpha-proton of carboxylic acids.
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       ECO: b3692(dgoA)
            SME: SMb20510(dgoA)
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
            PS: PS00909  [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-
                         [LIVM]-E-[DENQ]-P
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.6
            ExPASy - ENZYME nomenclature database: 4.2.1.6
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.6
            BRENDA, the Enzyme Database: 4.2.1.6
///
ENTRY       EC 4.2.1.7
NAME        Altronate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Altronate hydro-lyase
REACTION    D-Altronate = 2-Dehydro-3-deoxy-D-gluconate + H2O
SUBSTRATE   D-Altronate
PRODUCT     2-Dehydro-3-deoxy-D-gluconate
            H2O
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b3091(uxaA)
            ECE: Z4444(uxaA)
            ECS: ECs3973
            YPE: YPO0581(uxaA)
            CJE: Cj0482(uxaA') Cj0483(uxaA')
            MLO: mlr3330
            SME: SMc02776
            CCR: CC1488
            BSU: BG13213(uxaA)
            BHA: BH0490
            CAC: CAC0696
            TAC: Ta1392 Ta1393
            SSO: SSO1259(garD) SSO1260
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.7
            ExPASy - ENZYME nomenclature database: 4.2.1.7
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.7
            BRENDA, the Enzyme Database: 4.2.1.7
///
ENTRY       EC 4.2.1.8
NAME        Mannonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Mannonate hydro-lyase
REACTION    D-Mannonate = 2-Dehydro-3-deoxy-D-gluconate + H2O
SUBSTRATE   D-Mannonate
PRODUCT     2-Dehydro-3-deoxy-D-gluconate
            H2O
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b4322(uxuA)
            ECE: Z5920(uxuA)
            ECS: ECs5281
            YPE: YPO1283(uxuA)
            HIN: HI0055(uxuA)
            MLO: mlr6866
            SME: SMb20446(uxuA)
            BSU: BG13208(uxuA)
            BHA: BH0706 BH1063
            LLA: L0020(uxuA)
            CAC: CAC1332(uxuA)
            TMA: TM0069
            TAC: Ta0753
            TVO: TVG0075057
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.8
            ExPASy - ENZYME nomenclature database: 4.2.1.8
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.8
            BRENDA, the Enzyme Database: 4.2.1.8
///
ENTRY       EC 4.2.1.9
NAME        Dihydroxy-acid dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2,3-Dihydroxy-acid hydro-lyase
REACTION    2,3-Dihydroxy-3-methylbutanoate = 3-Methyl-2-oxobutanoate + H2O
SUBSTRATE   2,3-Dihydroxy-3-methylbutanoate
PRODUCT     3-Methyl-2-oxobutanoate
            H2O
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b3771(ilvD)
            ECE: Z5282(ilvD)
            ECS: ECs4705
            YPE: YPO3897(ilvD)
            HIN: HI0738(ilvD)
            PMU: PM1625(ilvD)
            XFA: XF0099
            VCH: VC0028
            PAE: PA0353(ilvD)
            BUC: BU600(ilvD)
            NME: NMB1150 NMB1188
            NMA: NMA1361(ilvD)
            CJE: Cj0013(ilvD)
            MLO: mll1102 mll7192 mlr5361 mlr5404
            SME: SMa0235 SMb20115(ilvD4) SMb20890(ilvD5) SMc00884(ilvD1)
                 SMc04045(ilvD2) SMc04144(ilvD3)
            ATU: AGR_L_1769
            CCR: CC0819 CC3044
            BSU: BG11532(ilvD)
            BHA: BH3062(ilvD)
            SAU: SA1858(ilvD)
            SAV: SAV2038(ilvD)
            LLA: L0077(ilvD)
            SPN: SP2126
            SPR: spr1935(ilvD)
            CAC: CAC3170(ilvD)
            MTU: Rv0189c(ilvD)
            MTC: MT0199
            MLE: ML2608(ilvD)
            SYN: slr0452(ilvD)
            DRA: DR1132
            AAE: aq_837(ilvD)
            TMA: TM0551
            MJA: MJ1276(ilvD)
            MTH: MTH1449
            AFU: AF1014(ilvD)
            PAB: PAB0895(ilvD)
            APE: APE0013
            SSO: SSO3107(ilvD)
            SCE: YJR016C(ILV3)
            SPO: SPAC17G8.06C(spac17g8.06c)
MOTIF       PS: PS00886  C-D-K-x(2)-P-[GA]-x(3)-[GA]
            PS: PS00887  [SGAL]-[LI]-[LIVM]-T-D-[GA]-R-[LIVMF]-S-[GA]-[GAV]-[ST]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.9
            ExPASy - ENZYME nomenclature database: 4.2.1.9
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.9
            BRENDA, the Enzyme Database: 4.2.1.9
///
ENTRY       EC 4.2.1.10
NAME        3-Dehydroquinate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Dehydroquinate hydro-lyase
REACTION    3-Dehydroquinate = 3-Dehydroshikimate + H2O
SUBSTRATE   3-Dehydroquinate
PRODUCT     3-Dehydroshikimate
            H2O
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1693(aroD)
            ECE: Z2721(aroD)
            ECS: ECs2400
            YPE: YPO3660(aroQ)
            HIN: HI0970(aroQ)
            PMU: PM1093(aroD)
            XFA: XF0047
            VCH: VC0297
            PAE: PA0245(aroQ2) PA4846(aroQ1)
            BUC: BU399(aroD)
            NME: NMB1446
            NMA: NMA1659(aroD)
            HPY: HP1038(aroQ)
            HPJ: jhp0386
            CJE: Cj0066c(aroQ)
            MLO: mll0207
            SME: SMc01343(aroQ)
            CCR: CC1882
            BSU: BG10538(aroC) BG11707(yqhS)
            BHA: BH2801
            SAU: SA0756
            SAV: SAV0813
            LLA: L0062(aroD)
            SPY: SPy0809(aroD)
            SPN: SP1377
            SPR: spr1235(aroD)
            CAC: CAC0899
            MTU: Rv2537c(aroD)
            MTC: MT2612
            MLE: ML0519(aroD)
            CTR: CT370
            CMU: TC0649
            CPN: CPn1035
            CPA: CP0817
            CPJ: aroE
            SYN: sll1112(aroQ)
            DRA: DR0778
            AAE: aq_021(aroD)
            TMA: TM0349
            MJA: MJ1454(aroD)
            MTH: MTH566
            AFU: AF0228(aroD)
            TVO: TVG0199907
            PAB: PAB0299(aroD)
            APE: APE0577
            SSO: SSO0311(aroD)
            SCE: YDR127W(ARO1)
MOTIF       PS: PS00104  [LIVF]-x(2)-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-x-R-
                         x-[LIVMFYAT]-x-[GSTAP]
            PS: PS00885  [KR]-x-[KH]-E-[CST]-[DNE]-R-[LIVM]-x-[GSTAV]-[LIVMCT]-
                         x(3)-[LIVMF]-x(2)-[LIVMFCGAN]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-
                         H-[DN]
            PS: PS01029  [LIVM]-[NQH]-G-P-N-[LV]-x(2)-L-G-x-R-[QED]-x(3)-[FY]-G
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMFG]
STRUCTURES  PDB: 2DHQ  1QFE  1D0I  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.10
            ExPASy - ENZYME nomenclature database: 4.2.1.10
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.10
            BRENDA, the Enzyme Database: 4.2.1.10
            SCOP (Structural Classification of Proteins): 4.2.1.10
///
ENTRY       EC 4.2.1.11
NAME        Phosphopyruvate hydratase
            Enolase
            2-Phosphoglycerate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Phospho-D-glucerate hydro-lyase
REACTION    2-Phospho-D-glycerate = Phosphoenolpyruvate + H2O;
            3-Phospho-D-erythronate =
            Phosphoenol-4-deoxy-3-tetrulosonate + H2O
SUBSTRATE   2-Phospho-D-glycerate
            3-Phospho-D-erythronate
PRODUCT     Phosphoenolpyruvate
            H2O
            Phosphoenol-4-deoxy-3-tetrulosonate
INHIBITOR   Phosphonoacetohydroxamate
COMMENT     Also acts on 3-phospho-D-erythronate.
            Ki of phosphonoacetohydroxamate is 15 picoM as the trianion with
            saturation Mg++ ion (Biochemistry, 1984, 23, 2779).  Crystal
            structure of the inhibitor complex (Biochemistry, 1994, 33,
            6295-6300).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2779(eno)
            ECE: Z4094(eno)
            ECS: ECs3639
            YPE: YPO3376(eno)
            HIN: HI0932(eno)
            PMU: PM1871(eno)
            XFA: XF1291
            VCH: VC2447
            PAE: PA3635(eno)
            BUC: BU417(eno)
            NME: NMB1285
            NMA: NMA1495(eno)
            HPY: HP0154(eno)
            HPJ: jhp0142
            CJE: Cj1672c(eno)
            MLO: mlr0378
            SME: SMc01028(eno)
            CCR: CC1724
            BSU: BG10899(eno)
            BHA: BH3556(eno)
            SAU: SA0731(eno)
            SAV: SAV0763(eno)
            LLA: L0007(enoA) L0008(enoB)
            SPY: SPy0731(eno)
            SPN: SP1128
            SPR: spr1036(eno)
            CAC: CAC0713(eno)
            MGE: MG407(eno)
            MPN: C12_orf456(eno)
            MPU: MYPU_5180(eno)
            UUR: UU184(eno)
            MTU: Rv1023(eno)
            MTC: MT1051
            MLE: ML0255(eno)
            CTR: CT587
            CMU: TC0876
            CPN: CPn0800
            CPA: CP1071
            CPJ: eno
            BBU: BB0337(eno)
            TPA: TP0817
            SYN: slr0752(eno)
            DRA: DR2637
            AAE: aq_484(eno)
            TMA: TM0877
            MJA: MJ0232(eno)
            MTH: MTH43
            AFU: AF1132(eno)
            HAL: VNG1142G(eno)
            TAC: Ta0882
            TVO: TVG1033459
            PHO: PH1942
            PAB: PAB1126(eno)
            APE: APE2458
            SSO: SSO0913
            STO: ST1212
            SCE: YGR254W(ENO1) YHR174W(ENO2) YMR323W(YMR323W)
            SPO: ENO1(eno1) SPO05
            ATH: At2g36530(F1O11.16)
            CEL: T21B10.2
            DME: CG17654(Eno)
            MMU: 95393(Eno1) 95395(Eno3)
            HSA: 2023(ENO1) 2026(ENO2) 2027(ENO3) 26237(ENO1B)
DISEASE     MIM: 131360  Enolase-2, gamma, neuronal
            MIM: 131370  Enolase-3, beta, muscle
            MIM: 172430  Enolase-1, alpha
MOTIF       PS: PS00164  [LIV](3)-K-x-N-Q-I-G-[ST]-[LIV]-[ST]-[DE]-[STA]
STRUCTURES  PDB: 7ENL  1ELS  1NEL  1EBG  5ENL  4ENL  1EBH  3ENL  2ONE  1PDZ  
                 1PDY  1ONE  6ENL  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.11
            ExPASy - ENZYME nomenclature database: 4.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.11
            BRENDA, the Enzyme Database: 4.2.1.11
            SCOP (Structural Classification of Proteins): 4.2.1.11
///
ENTRY       EC 4.2.1.12
NAME        Phosphogluconate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     6-Phospho-D-gluconate hydro-lyase
REACTION    6-Phospho-D-gluconate =
            2-Dehydro-3-deoxy-6-phospho-D-gluconate + H2O
SUBSTRATE   6-Phospho-D-gluconate
PRODUCT     2-Dehydro-3-deoxy-6-phospho-D-gluconate
            H2O
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
GENES       ECO: b1851(edd)
            ECE: Z2903(edd)
            ECS: ECs2561
            YPE: YPO2533(edd)
            XFA: XF1062
            VCH: VC0288
            PAE: PA3194(edd)
            NME: NMB1393
            NMA: NMA1610(edd)
            HPY: HP1100(edd)
            HPJ: jhp1026
            MLO: mll6512
            SME: SMc03068(edd)
            CCR: CC2055
MOTIF       PS: PS00886  C-D-K-x(2)-P-[GA]-x(3)-[GA]
            PS: PS00887  [SGAL]-[LI]-[LIVM]-T-D-[GA]-R-[LIVMF]-S-[GA]-[GAV]-[ST]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.12
            ExPASy - ENZYME nomenclature database: 4.2.1.12
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.12
            BRENDA, the Enzyme Database: 4.2.1.12
///
ENTRY       EC 4.2.1.13
NAME        L-Serine dehydratase
            Serine deaminase
            L-Hydroxyaminoacid dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Serine hydro-lyase (deaminating)
REACTION    L-Serine + H2O = Pyruvate + NH3 + H2O
SUBSTRATE   L-Serine
            H2O
PRODUCT     Pyruvate
            NH3
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. This reaction is also carried out
            by EC 4.2.1.16 from a number of sources
            (EC 4.2.1.16 Threonine dehydratase)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00272  Cysteine metabolism
GENES       ECO: b1814(sdaA) b2797(sdaB) b3111(yhaP) b3112(yhaQ)
            ECE: Z2857(sdaA) Z4114(sdaB) Z4464
            ECS: ECs2523 ECs3657 ECs3992
            YPE: YPO1771(sdaA)
            HIN: HI0288(sdaA)
            PMU: PM0036(sdaA)
            VCH: VC1300 VCA0666
            PAE: PA2443(sdaA) PA5379(sdaB)
            NME: NMB0211
            NMA: NMA0057(sdaA)
            HPY: HP0132(sdaA)
            HPJ: jhp0120
            CJE: Cj1624c(sdaA)
            MLO: mll0670
            SME: SMc01256(sda)
            CCR: CC3108
            BSU: BG13397(sdaAB) BG13398(sdaAA)
            BHA: BH2496 BH2497
            SAU: SA2318 SA2319
            SAV: SAV2513 SAV2514
            LLA: L43452(sdaB) L44083(sdaA)
            SPY: SPy2189(sdhB) SPy2190(sdhA)
            SPN: SP0105 SP0106
            SPR: spr0094(sdaA) spr0095(sdaB)
            CAC: CAC0673 CAC0674
            MTU: Rv0069c(sdaA)
            MTC: MT0075
            MLE: ML1755(sdaA)
            DRA: DR0377 DR0497
            SCE: YCL064C(CHA1) YIL167W(YIL167W) YIL168W(SDL1)
            HSA: 10993(SDS)
MOTIF       PS: PS00165  [DESH]-x(4,5)-[STVG]-x-[AS]-[FYI]-K-[DLIFSA]-[RVMF]-
                         [GA]-[LIVMGA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.13
            ExPASy - ENZYME nomenclature database: 4.2.1.13
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.13
            BRENDA, the Enzyme Database: 4.2.1.13
///
ENTRY       EC 4.2.1.14
NAME        D-Serine dehydratase
            D-Hydroxyaminoacid dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Serine hydro-lyase(deaminating)
REACTION    D-Serine + H2O = Pyruvate + NH3 + H2O
SUBSTRATE   D-Serine
            H2O
            D-Threonine
PRODUCT     Pyruvate
            NH3
            H2O
            2-Oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts, slowly, on  D-threonine
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b2366(dsdA)
            ECE: Z3628(dsdA)
            ECS: ECs3245
            VCH: VCA0875
            PAE: PA3357(dsdA)
            BSU: BG11747(dsdA)
            BHA: BH1762(dsdA)
MOTIF       PS: PS00165  [DESH]-x(4,5)-[STVG]-x-[AS]-[FYI]-K-[DLIFSA]-[RVMF]-
                         [GA]-[LIVMGA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.14
            ExPASy - ENZYME nomenclature database: 4.2.1.14
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.14
            BRENDA, the Enzyme Database: 4.2.1.14
///
ENTRY       EC 4.2.1.15
NAME        Deleted entry
            Homoserine dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Deleted entry. Identical with EC 4.4.1.1.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.15
            ExPASy - ENZYME nomenclature database: 4.2.1.15
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.15
///
ENTRY       EC 4.2.1.16
NAME        Threonine dehydratase
            Threonine deaminase
            L-Serine dehydratase
            Serine deaminase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Threonine hydro-lyase (deaminating)
REACTION    L-Threonine + H2O = 2-Oxobutanoate + NH3 + H2O
SUBSTRATE   L-Threonine
            L-Serine
            H2O
PRODUCT     2-Oxobutanoate
            2-Oxopropanoate
            NH3
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     The enzyme from many sources is a pyridoxal-phosphate protein;
            that from P.putida is not. The enzyme from a number of sources
            also acts on L-serine. (cf. EC 4.2.1.13 L-Serine dehydratase)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
GENES       ECO: b3117(tdcB) b3772(ilvA)
            ECE: Z4469(tdcB) Z5283(ilvA)
            ECS: ECs3997 ECs4706
            YPE: YPO3896(ilvA) YPO4089
            HIN: HI0738.1(ilvA)
            PMU: PM1624(ilvA)
            XFA: XF1819
            VCH: VC0027
            PAE: PA0331(ilvA1) PA1326(ilvA2)
            NME: NMB0878
            NMA: NMA1096(ilvA)
            CJE: Cj0828c(ilvA)
            RPR: RP449(tdcB)
            RCO: RC0628(tdcB)
            MLO: mll4597 mll7611 mlr0162 mlr3510 mlr7138
            SME: SMb20432 SMc00936(ilvA)
            CCR: CC3105 CC3635
            BSU: BG10673(ilvA)
            BHA: BH1711(ilvA)
            SAU: SA1271 SA1866(ilvA)
            SAV: SAV1427 SAV2046(ilvA)
            LLA: L0081(ilvA)
            SPN: SP0450
            SPR: spr0406(ilvA)
            MTU: Rv1559(ilvA)
            MTC: MT1610
            MLE: ML1209(ilvA)
            SYN: slr2072(ilvA)
            DRA: DR0567
            TMA: TM0356
            HAL: VNG2100G(iluA)
            TAC: Ta0113
            TVO: TVG0197397
            APE: APE1498
            SSO: SSO0248(tdcB)
            STO: ST0295
            SCE: YCL064C(CHA1) YER086W(ILV1)
            SPO: SPBC1677.03C(spbc1677.03c) SPCC330.15C
            CEL: K01C8.1 T01H8.2
            DME: CG8129 CG8129_1
MOTIF       PS: PS00165  [DESH]-x(4,5)-[STVG]-x-[AS]-[FYI]-K-[DLIFSA]-[RVMF]-
                         [GA]-[LIVMGA]
STRUCTURES  PDB: 1TDJ  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.16
            ExPASy - ENZYME nomenclature database: 4.2.1.16
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.16
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.16
            BRENDA, the Enzyme Database: 4.2.1.16
            SCOP (Structural Classification of Proteins): 4.2.1.16
///
ENTRY       EC 4.2.1.17
NAME        Enoyl-CoA hydratase
            Enoyl hydrase
            Unsaturated acyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3S)-3-Hydroxyacyl-CoA hydro-lyase
REACTION    (3S)-3-Hydroxyacyl-CoA = trans-2,3-Dehydroacyl-CoA + H2O;
            (3R)-3-Hydroxyacyl-CoA = cis-2,3-Dehydroacyl-CoA + H2O
SUBSTRATE   (3S)-3-Hydroxyacyl-CoA
            (3R)-3-Hydroxyacyl-CoA
            2-Methylprop-2-enoyl-CoA
            2-Methylbut-2-enoyl-CoA
            3-Methylbut-2-enoyl-CoA
PRODUCT     trans-2,3-Dehydroacyl-CoA
            cis-2,3-Dehydroacyl-CoA
            H2O
            3-Hydroxy-2-methylpropanoyl-CoA
            (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
            trans-3-Methylglutaconyl-CoA
COMMENT     Acts in the reverse direction. With cis-compounds, yields
            (3R)-3-hydroxyacyl-CoA. (cf. EC 4.2.1.74 Long-chain-enoyl-CoA
            hydratase)
PATHWAY     PATH: MAP00062  Fatty acid biosynthesis (path 2)
            PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00310  Lysine degradation
            PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       ECO: b1393(paaF) b1394(paaG) b2341 b3846(fadB)
            ECE: Z3604 Z5367(fadB)
            ECS: ECs3224 ECs4774
            YPE: YPO2747(faoA) YPO3766(fadB)
            VCH: VC1047 VC2758
            PAE: PA0744 PA0745 PA1021 PA1240 PA1629 PA1737 PA1748 PA1821
                 PA2013 PA2767 PA2841 PA2890 PA3014(faoA) PA3426 PA3591 PA4330
                 PA4980
            RPR: RP560(fadB)
            MLO: mll1009 mll4199 mll5431 mll5584 mlr5044 mlr5629 mlr8461
            SME: SMb20752 SMb21126(eccH2) SMb21633(paaG) SMc00976 SMc01153
                 SMc01641 SMc02227(fadB) SMc04398
            CCR: CC0006 CC0076 CC0353 CC0397 CC0947 CC1723 CC1814 CC2169
                 CC2575 CC3189
            BSU: BG12331(ysiB) BG13457(yngF) BG14024(yusL)
            BHA: BH0201(phaA) BH0202(phaB) BH0207 BH1135 BH1849 BH1996 BH2582
                 BH3101 BH3488 BH3824
            SAU: SA0224
            SAV: SAV0225(fadB)
            SPY: SPy1758(phaB)
            SPN: SP0415
            SPR: spr0375(phaB)
            MTU: Rv0632c(echA3) Rv0675(echA5) Rv0860(fadB) Rv0905(echA6)
                 Rv0971c(echA7) Rv1070c(echA8) Rv1472(echA12) Rv2486(echA14)
                 Rv2679(echA15) Rv2831(echA16) Rv3039c(echA17) Rv3516(echA19)
                 Rv3550(echA20)
            MTC: MT0660 MT0704 MT0883 MT0928 MT0999.1 MT1100 MT1518 MT2560
                 MT2753 MT2897 MT3124 MT3617 MT3654
            MLE: ML1241 ML1724 ML2118(echA6) ML2161(fadB) ML2402
            DRA: DR0114 DR0184 DR1487 DR2510
            AFU: AF0017(hbd-1) AF0285(hbd-2) AF0435(fad-1) AF0685(fad-2)
                 AF0963(fad-3) AF1122(hbd-5) AF1641(fad-4) AF2273(hbd-10)
                 AF2429(fad-5)
            HAL: VNG0428G(fad2) VNG1313G(hbd2) VNG2032G(fad1)
            TAC: Ta0061 Ta0121 Ta0291 Ta0440
            TVO: TVG0015475 TVG0203661 TVG0968612 TVG1375310
            APE: APE0056 APE0591 APE1484
            SSO: SSO0050(paaF-1) SSO0654(paaF-2) SSO1311(paaF-3)
                 SSO2017(paaF-4) SSO2514 SSO2535(paaF-5) SSO2623(paaF-6)
                 SSO2624(paaF-7)
            STO: ST0069 ST0095
            CEL: C29F3.1 F38H4.8 F43H9.1 F56B3.5 T05G5.6 T08B2.7
            DME: CG4389(BcDNA:GH12558)
            HSA: 1892(ECHS1) 1962(EHHADH) 3030(HADHA)
DISEASE     MIM: 600890  Hydroxyacyl-Coenzyme A
                         dehydrogenase/3-ketoacyl-Coenzyme A thiolase/
MOTIF       PS: PS00067  [DNE]-x(2)-[GA]-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-
                         [LIVMFY](2)-x(5)-[LIVMFYCT]-[LIVMFY]-x(2)-[GV]
            PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1DUB  2DUB  1DCI  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.17
            ExPASy - ENZYME nomenclature database: 4.2.1.17
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.17
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.17
            BRENDA, the Enzyme Database: 4.2.1.17
            SCOP (Structural Classification of Proteins): 4.2.1.17
///
ENTRY       EC 4.2.1.18
NAME        Methylglutaconyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (S)-3-Hydroxy-3-methylglutaryl-CoA hydro-lyase
REACTION    (S)-3-Hydroxy-3-methylglutaryl-CoA =
            trans-3-Methylglutaconyl-CoA + H2O
SUBSTRATE   (S)-3-Hydroxy-3-methylglutaryl-CoA
PRODUCT     trans-3-Methylglutaconyl-CoA
            H2O
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.18
            ExPASy - ENZYME nomenclature database: 4.2.1.18
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.18
            BRENDA, the Enzyme Database: 4.2.1.18
///
ENTRY       EC 4.2.1.19
NAME        Imidazoleglycerol-phosphate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate hydro-lyase
REACTION    D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate =
            3-(Imidazol-4-yl)-2-oxopropyl phosphate + H2O
SUBSTRATE   D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate
PRODUCT     3-(Imidazol-4-yl)-2-oxopropyl phosphate
            H2O
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2022(hisB)
            ECE: Z3184(hisB)
            ECS: ECs2823
            YPE: YPO1546(hisB)
            HIN: HI0471(hisB)
            PMU: PM1200(hisB)
            XFA: XF2217
            VCH: VC1135
            PAE: PA5143(hisB)
            BUC: BU102(hisB)
            NME: NMB1583
            NMA: NMA1772(hisB)
            CJE: Cj1599(hisB)
            MLO: mlr5008
            SME: SMc02574(hisB)
            CCR: CC3734
            BSU: BG12598(hisB)
            BHA: BH3581(hisB)
            SAU: SA2468(hisB)
            SAV: SAV2661(hisB)
            LLA: L0068(hisB)
            CAC: CAC0938(hisB)
            MTU: Rv1601(hisB)
            MTC: MT1637
            MLE: ML1259(hisB)
            SYN: sll0084(hisB) slr0500(hisB)
            DRA: DR0424
            AAE: aq_039(hisB)
            TMA: TM1039
            MJA: MJ0698(hisB)
            MTH: MTH1467(hisB)
            AFU: AF0985(hisB)
            HAL: VNG2295G(hisB)
            SSO: SSO0596(hisB)
            SCE: YOR202W(HIS3)
            SPO: HIS5(his5)
            ATH: At4g14910(dl3495c)
MOTIF       PS: PS00954  [LIVMY]-[DE]-x-H-H-x(2)-E-x(2)-[GCA]-[LIVM]-[STAVC]-
                         [LIVM]
            PS: PS00955  G-x-[DNI]-x-H-H-x(2)-E-[STAGC]-x-[VMFY]-K
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.19
            ExPASy - ENZYME nomenclature database: 4.2.1.19
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.19
            BRENDA, the Enzyme Database: 4.2.1.19
///
ENTRY       EC 4.2.1.20
NAME        Tryptophan synthase
            Tryptophan desmolase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Serine hydro-lyase (adding indoleglycerol-phosphate)
REACTION    L-Serine + 1-(Indol-3-yl)glycerol 3-phosphate =
            L-Tryptophan + Glyceraldehyde 3-phosphate + H2O
SUBSTRATE   L-Serine
            1-(Indol-3-yl)glycerol 3-phosphate
            Indole
PRODUCT     L-Tryptophan
            Glyceraldehyde 3-phosphate
            H2O
            Indole
INHIBITOR   1-(Indol-3-yl)propanol 3-phosphate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses the conversion of
            serine and indole into tryptophan and water and of indoleglycerol
            phosphate into indole and glyceraldehyde phosphate (the latter
            reaction formerly listed as EC 4.1.2.8). In some organisms, this
            enzyme is part of a multifunctional protein together with one or
            more other components of the system for biosynthesis of tryptophan
            (EC 2.4.2.18, 4.1.1.48, 4.1.3.27, 5.3.1.24).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1260(trpA) b1261(trpB)
            ECE: Z2550(trpB) Z2551(trpA)
            ECS: ECs1832 ECs1833
            YPE: YPO2203(trpA) YPO2204(trpB)
            HIN: HI1431(trpB) HI1432(trpA)
            PMU: PM0577(trpA) PM0578(trpB)
            XFA: XF1375 XF1376
            VCH: VC1169 VC1170
            PAE: PA0035 PA0036(trpB)
            BUC: BU277(trpA) BU278(trpB)
            NME: NMB0678 NMB0699
            NMA: NMA0879(trpA) NMA0904(trpB)
            HPY: HP1277(tpra) HP1278(trpB)
            HPJ: jhp1198 jhp1199
            CJE: Cj0348(trpB) Cj0349(trpA)
            MLO: mlr5071 mlr5073
            SME: SMc02765(trpA) SMc02766(trpB)
            CCR: CC3543 CC3544
            BSU: BG10290(trpB) BG10291(trpA)
            BHA: BH1663(trpB) BH1664(trpA)
            SAU: SA1204(trpB) SA1205(trpA)
            SAV: SAV1357(trpB) SAV1358(trpA)
            LLA: L0048(trpA) L0049(trpB)
            SPN: SP1811 SP1812
            SPR: spr1631(trpA) spr1632(trpB)
            CAC: CAC3157(trpA) CAC3158(trpB)
            MTU: Rv1612(trpB) Rv1613(trpA)
            MTC: MT1647 MT1648
            MLE: ML1272(trpB) ML1273(trpA)
            CTR: CT170 CT171
            SYN: slr0543(trpB) slr0966(trpA)
            DRA: DR0941 DR0942
            AAE: aq_1410(trpB2) aq_1548(trpA) aq_706(trpB1)
            TMA: TM0137 TM0138 TM0539
            MJA: MJ1037(trpB) MJ1038(trpA)
            MTH: MTH1476 MTH1659(trpB) MTH1660(trpA)
            AFU: AF1240(trpB-1) AF1599(trpA) AF1600(trpB-2)
            HAL: VNG0307G(trpB) VNG0308G(trpA)
            TAC: Ta0669 Ta0803
            TVO: TVG0983765 TVG1081798
            PHO: PH1583
            PAB: PAB1970(trpB-2) PAB2048(trpB-1) PAB2049(trpA)
            APE: APE2316 APE2548 APE2550
            SSO: SSO0888(trpB) SSO0889(trpA) SSO1145(trpB-like)
            STO: ST1232 ST1233
            SCE: YGL026C(TRP5)
            SPO: SPAC19A8.15(spac19a8.15)
            ATH: At4g27070(T24A18.20)
MOTIF       PS: PS00167  [LIVM]-E-[LIVM]-G-x(2)-[FYC]-[ST]-[DE]-[PA]-[LIVMYG]-
                         [SGALIM]-[DE]-G
            PS: PS00168  [LIVMYA]-x-[HP]-x-G-[STA]-H-K-x-N-x(2)-[LIVM]-x-Q
STRUCTURES  PDB: 1QOP  1QOQ  1TTP  1CW2  1GEQ  2TSY  2TYS  2WSY  1FUY  1UBS  
                 2TRS  1CX9  1BKS  1C29  1TTQ  1A50  1C9D  1A5A  1A5B  1A5S  
                 1BEU  1C8V  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.20
            ExPASy - ENZYME nomenclature database: 4.2.1.20
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.20
            BRENDA, the Enzyme Database: 4.2.1.20
            SCOP (Structural Classification of Proteins): 4.2.1.20
///
ENTRY       EC 4.2.1.21
NAME        Deleted entry
            Cystathionine beta-synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Deleted entry. Now EC 4.2.1.22.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.21
            ExPASy - ENZYME nomenclature database: 4.2.1.21
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.21
///
ENTRY       EC 4.2.1.22
NAME        Cystathionine beta-synthase
            Serine sulfhydrase
            beta-Thionase
            Methylcysteine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Serine hydro-lyase (adding homocysteine)
REACTION    L-Serine + L-Homocysteine = Cystathionine + H2O
SUBSTRATE   L-Serine
            L-Homocysteine
            L-Cysteine
            Cysteine thioether
            beta-Substituted alpha-L-amino acid
PRODUCT     Cystathionine
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses
            beta-replacement reactions between L-serine, L-cysteine, cysteine
            thioethers or some other beta-substituted alpha-L-amino acids and
            a variety of mercaptans.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00271  Methionine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
GENES       XFA: XF0603
            PAE: PA0399
            MLO: mll4505
            MTU: Rv1077(cysM2)
            MTC: MT1108
            MLE: ML2396(cysM2)
            APE: APE1223
            SCE: YGR155W(CYS4)
            CEL: ZC373.1
            DME: CG1753
            MMU: 88285(Cbs)
            HSA: 875(CBS)
DISEASE     MIM: 236200  Cystathionine beta-synthase
MOTIF       PS: PS00901  K-x-E-x(3)-[PA]-[STAGC]-x-S-[IVAP]-K-x-R-x-[STAG]-x(2)-
                         [LIVM]
STRUCTURES  PDB: 1JBQ  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.22
            ExPASy - ENZYME nomenclature database: 4.2.1.22
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.22
            BRENDA, the Enzyme Database: 4.2.1.22
///
ENTRY       EC 4.2.1.23
NAME        Deleted entry
            Methylcysteine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Deleted entry. (a side-reaction of EC 4.2.1.22.)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.23
            ExPASy - ENZYME nomenclature database: 4.2.1.23
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.23
///
ENTRY       EC 4.2.1.24
NAME        Porphobilinogen synthase
            Aminolevulinate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     5-Aminolevulinate hydro-lyase(adding 5-aminolevulinate and
            cyclizing)
REACTION    2 5-Aminolevulinate = Porphobilinogen + 2 H2O
SUBSTRATE   5-Aminolevulinate
PRODUCT     Porphobilinogen
            H2O
COFACTOR    Metal
COMMENT     The fungal enzyme is a metalloprotein.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b0369(hemB)
            ECE: Z0468(hemB)
            ECS: ECs0423
            YPE: YPO3771(hemB)
            PMU: PM1692(hemB)
            XFA: XF2306
            VCH: VC0105
            PAE: PA5243(hemB)
            NME: NMB0801
            NMA: NMA1011(hemB)
            HPY: HP0163(hemB)
            HPJ: jhp0150
            CJE: Cj0995c(hemB)
            RPR: RP539(hemB)
            RCO: RC0798(hemB)
            MLO: mll8390
            SME: SMc01766(hemB)
            CCR: CC1347
            BSU: BG10344(hemB)
            BHA: BH3044(hemB)
            SAU: SA1492(hemB)
            SAV: SAV1652(hemB)
            CAC: CAC0100(hemB)
            MTU: Rv0512(hemB)
            MTC: MT0533
            MLE: ML2419(hemB)
            CTR: CT633
            CMU: TC0001
            CPN: CPn0744
            CPA: CP0001
            CPJ: hemB
            SYN: sll1994(hemB)
            DRA: DR2160
            AAE: aq_2109(hemB)
            MJA: MJ0643(hemB)
            MTH: MTH744
            AFU: AF1974(hemB)
            HAL: VNG2322G(hem2)
            TAC: Ta0955
            TVO: TVG1155064
            APE: APE2300
            SSO: SSO0181
            STO: ST0214
            SCE: YGL040C(HEM2)
            SPO: HEM2(hem2)
            DME: CG10335
            MMU: 96853
            HSA: 210(ALAD)
DISEASE     MIM: 125270  Aminolevulinate, delta-, dehydratase
MOTIF       PS: PS00169  G-x-D-x-[LIVM](2)-[IV]-K-P-[GSA]-x(2)-Y
STRUCTURES  PDB: 1GJP  1YLV  1QNV  1QML  1I8J  1H7R  1E51  1B4K  1B4E  1AW5  
                 1H7N  1EB3  1H7O  1H7P  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.24
            ExPASy - ENZYME nomenclature database: 4.2.1.24
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.24
            BRENDA, the Enzyme Database: 4.2.1.24
            SCOP (Structural Classification of Proteins): 4.2.1.24
///
ENTRY       EC 4.2.1.25
NAME        L-Arabinonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Arabinonate hydro-lyase
REACTION    L-Arabinonate = 2-Dehydro-3-deoxy-L-arabinonate + H2O
SUBSTRATE   L-Arabinonate
PRODUCT     2-Dehydro-3-deoxy-L-arabinonate
            H2O
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.25
            ExPASy - ENZYME nomenclature database: 4.2.1.25
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.25
            BRENDA, the Enzyme Database: 4.2.1.25
///
ENTRY       EC 4.2.1.26
NAME        Aminodeoxygluconate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Amino-2-deoxy-D-gluconate hydro-lyase (deaminating)
REACTION    2-Amino-2-deoxy-D-gluconate + H2O =
            2-Dehydro-3-deoxy-D-gluconate + NH3 + H2O
SUBSTRATE   2-Amino-2-deoxy-D-gluconate
            H2O
PRODUCT     2-Dehydro-3-deoxy-D-gluconate
            NH3
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.26
            ExPASy - ENZYME nomenclature database: 4.2.1.26
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.26
            BRENDA, the Enzyme Database: 4.2.1.26
///
ENTRY       EC 4.2.1.27
NAME        Malonate-semialdehyde dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Oxopropanoate hydro-lyase
REACTION    3-Oxopropanoate = Propynoate + H2O
SUBSTRATE   3-Oxopropanoate
PRODUCT     Propynoate
            H2O
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.27
            ExPASy - ENZYME nomenclature database: 4.2.1.27
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.27
            BRENDA, the Enzyme Database: 4.2.1.27
///
ENTRY       EC 4.2.1.28
NAME        Propanediol dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Propane-1,2-diol hydro-lyase
REACTION    Propane-1,2-diol = Propanal + H2O
SUBSTRATE   Propane-1,2-diol
            Ethylene glycol
PRODUCT     Propanal
            H2O
            Acetaldehyde
COFACTOR    Cobamide
COMMENT     Requires a cobamide coenzyme. Also dehydrates ethylene glycol to
            acetaldehyde.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
STRUCTURES  PDB: 1EGV  1EGM  1EEX  1DIO  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.28
            ExPASy - ENZYME nomenclature database: 4.2.1.28
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.28
            BRENDA, the Enzyme Database: 4.2.1.28
            SCOP (Structural Classification of Proteins): 4.2.1.28
///
ENTRY       EC 4.2.1.29
NAME        Indoleacetaldoxime dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Indoleacetaldoxime hydro-lyase
REACTION    3-Indoleacetaldoxime = 3-Indoleacetonitrile + H2O
SUBSTRATE   3-Indoleacetaldoxime
PRODUCT     3-Indoleacetonitrile
            H2O
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.29
            ExPASy - ENZYME nomenclature database: 4.2.1.29
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.29
            BRENDA, the Enzyme Database: 4.2.1.29
///
ENTRY       EC 4.2.1.30
NAME        Glycerol dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Glycerol hydro-lyase
REACTION    Glycerol = 3-Hydroxypropanal + H2O
SUBSTRATE   Glycerol
PRODUCT     3-Hydroxypropanal
            H2O
COFACTOR    Cobamide
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
GENES       MLO: mll6722
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.30
            ExPASy - ENZYME nomenclature database: 4.2.1.30
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.30
            BRENDA, the Enzyme Database: 4.2.1.30
///
ENTRY       EC 4.2.1.31
NAME        Maleate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (R)-Malate hydro-lyase
REACTION    (R)-Malate = Maleic acid + H2O
SUBSTRATE   (R)-Malate
PRODUCT     Maleic acid
            H2O
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.31
            ExPASy - ENZYME nomenclature database: 4.2.1.31
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.31
            BRENDA, the Enzyme Database: 4.2.1.31
///
ENTRY       EC 4.2.1.32
NAME        L(+)-Tartrate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (R,R)-Tartrate hydro-lyase
REACTION    (R,R)-Tartaric acid = Oxaloacetate + H2O
SUBSTRATE   (R,R)-Tartaric acid
PRODUCT     Oxaloacetate
            H2O
COFACTOR    Iron
            Thiol
COMMENT     The enzyme exists in an inactive low-molecular form, which is
            converted into active enzyme in the presence of Fe2+ and thiol.
            cf. EC 4.2.1.81.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
GENES       ECO: b3061(ttdA) b3062(ttdB)
            ECE: Z4414(ttdA) Z4415(ttdB)
            ECS: ECs3944 ECs3945
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.32
            ExPASy - ENZYME nomenclature database: 4.2.1.32
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.32
            BRENDA, the Enzyme Database: 4.2.1.32
///
ENTRY       EC 4.2.1.33
NAME        3-Isopropylmalate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Isopropylmalate hydro-lyase
REACTION    3-Isopropylmalate = 2-Isopropylmaleate + H2O
SUBSTRATE   2-Isopropylmalate
            2-Isopropylmaleate
            H2O
PRODUCT     2-Isopropylmaleate
            H2O
            3-Isopropylmalate
            3-Hydroxy-4-methyl-3-carboxypentanoate
COMMENT     The enzyme also hydrates the product to 3-hydroxy-4-methyl-
            3-carboxypentanoate thus bringing about an interconversion
            between the two isomers.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
GENES       ECO: b0071(leuD) b0072(leuC)
            ECE: Z0080(leuD) Z0081(leuC)
            ECS: ECs0075 ECs0076
            YPE: YPO0530(leuD) YPO0531(leuC)
            HIN: HI0988(leuC) HI0989(leuD)
            PMU: PM1959(leuD) PM1960(leuC)
            XFA: XF2374 XF2375
            VCH: VC2492 VC2493
            PAE: PA3120(leuD) PA3121(leuC)
            BUC: BUpL06(leuC) BUpL07(leuD)
            NME: NMB1034 NMB1036
            NMA: NMA1450(leuC) NMA1452(leuD)
            CJE: Cj1716c(leuD) Cj1717c(leuC)
            MLO: mll4272 mll4408
            SME: SMc03795(leuD) SMc03823(leuC)
            CCR: CC0195 CC0196
            BSU: BG11949(leuC) BG11950(leuD)
            BHA: BH3055(leuD) BH3056(leuC)
            SAU: SA1864(leuC) SA1865(leuD)
            SAV: SAV2044(leuC) SAV2045(leuD)
            LLA: L0075(leuC) L0076(leuD)
            SPN: SP1255
            SPR: spr1133(leuD-truncation)
            CAC: CAC3172(leuD) CAC3173(leuC)
            MTU: Rv2987c(leuD) Rv2988c(leuC)
            MTC: MT3065 MT3066
            MLE: ML1684(leuD) ML1685(leuC)
            SYN: sll1444(leuD) sll1470(leuC)
            DRA: DR1610 DR1614 DR1778 DR1784
            AAE: aq_1398(leuD) aq_940(leuC)
            TMA: TM0291 TM0292 TM0554 TM0555
            MJA: MJ0499(leuC) MJ1003(leuC) MJ1271(leuD) MJ1277(leuD)
            MTH: MTH1386 MTH1387 MTH1631 MTH829
            AFU: AF0629(leuD-1) AF1761(leuD-2) AF1963 AF2199(leuC)
            PHO: PH1724 PH1726
            PAB: PAB0287(leuC-2) PAB0288(leuD-2) PAB0891(leuC-1)
                 PAB0892(leuD-1)
            SSO: SSO2470(leuD) SSO2471(leuC)
            STO: ST0599 ST0600
            SCE: YGL009C(LEU1)
            SPO: LEU2(leu2)
MOTIF       PS: PS00450  [LIVM]-x(2)-[GSACIVM]-x-[LIV]-[GTIV]-[STP]-C-x(0,1)-T-
                         N-[GSTANI]-x(4)-[LIVMA]
            PS: PS01244  G-x(2)-[LIVWPQ]-x(3)-[GAC]-C-[GSTAM]-[LIMPTA]-C-[LIMV]-
                         [GA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.33
            ExPASy - ENZYME nomenclature database: 4.2.1.33
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.33
            BRENDA, the Enzyme Database: 4.2.1.33
///
ENTRY       EC 4.2.1.34
NAME        (S)-2-Methylmalate dehydratase
            Mesaconate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (S)-2-Methylmalate hydro-lyase
REACTION    (S)-2-Methylmalate = 2-Methylfumarate + H2O
SUBSTRATE   (S)-2-Methylmalate
            Fumarate
PRODUCT     2-Methylfumarate
            H2O
            (S)-Malate
COMMENT     Also hydrates fumarate to (S)-malate
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.34
            ExPASy - ENZYME nomenclature database: 4.2.1.34
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.34
            BRENDA, the Enzyme Database: 4.2.1.34
///
ENTRY       EC 4.2.1.35
NAME        (R)-2-Methylmalate dehydratase
            Citraconate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (R)-2-Methylmalate hydro-lyase
REACTION    (R)-2-Methylmalate = 2-Methylmaleate + H2O
SUBSTRATE   (R)-2-Methylmalate
PRODUCT     2-Methylmaleate
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.35
            ExPASy - ENZYME nomenclature database: 4.2.1.35
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.35
            BRENDA, the Enzyme Database: 4.2.1.35
///
ENTRY       EC 4.2.1.36
NAME        Homoaconitate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Hydroxybutane-1,2,4-tricarboxylate hydro-lyase
REACTION    2-Hydroxybutane-1,2,4-tricarboxylate =
            But-1-ene-1,2,4-tricarboxylate + H2O
SUBSTRATE   2-Hydroxybutane-1,2,4-tricarboxylate
            1-Hydroxybutane-1,2,4-tricarboxylate
PRODUCT     But-1-ene-1,2,4-tricarboxylate
            H2O
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       SCE: YDR234W(LYS4)
            SPO: SPAC343.16(spac343.16)
MOTIF       PS: PS00450  [LIVM]-x(2)-[GSACIVM]-x-[LIV]-[GTIV]-[STP]-C-x(0,1)-T-
                         N-[GSTANI]-x(4)-[LIVMA]
            PS: PS01244  G-x(2)-[LIVWPQ]-x(3)-[GAC]-C-[GSTAM]-[LIMPTA]-C-[LIMV]-
                         [GA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.36
            ExPASy - ENZYME nomenclature database: 4.2.1.36
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.36
            BRENDA, the Enzyme Database: 4.2.1.36
///
ENTRY       EC 4.2.1.37
NAME        Transferred to EC 3.3.2.4
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Transferred entry. Now EC 3.3.2.4 - trans-Epoxysuccinate
            hydrolase.
STRUCTURES  PDB: 1DWO  1DWP  1DWQ  1E89  1E8D  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.37
            ExPASy - ENZYME nomenclature database: 4.2.1.37
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.37
            SCOP (Structural Classification of Proteins): 4.2.1.37
///
ENTRY       EC 4.2.1.38
NAME        erythro-3-Hydroxyaspartate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     erythro-3-Hydroxy-Ls-aspartate hydro-lyase (deaminating)
REACTION    erythro-3-Hydroxy-L-aspartate + H2O = Oxaloacetate + NH3 + H2O
SUBSTRATE   erythro-3-Hydroxy-L-aspartate
            H2O
PRODUCT     Oxaloacetate
            NH3
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.38
            ExPASy - ENZYME nomenclature database: 4.2.1.38
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.38
            BRENDA, the Enzyme Database: 4.2.1.38
///
ENTRY       EC 4.2.1.39
NAME        Gluconate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Gluconate hydro-lyase
REACTION    D-Gluconate = 2-Dehydro-3-deoxy-D-gluconate + H2O
SUBSTRATE   D-Gluconate
PRODUCT     2-Dehydro-3-deoxy-D-gluconate
            H2O
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
STRUCTURES  PDB: 1QJ4  1YAS  2YAS  3YAS  4YAS  5YAS  6YAS  7YAS  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.39
            ExPASy - ENZYME nomenclature database: 4.2.1.39
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.39
            BRENDA, the Enzyme Database: 4.2.1.39
            SCOP (Structural Classification of Proteins): 4.2.1.39
///
ENTRY       EC 4.2.1.40
NAME        Glucarate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Glucarate hydro-lyase
REACTION    D-Glucarate = 5-Dehydro-4-deoxy-D-glucarate + H2O
SUBSTRATE   D-Glucarate
PRODUCT     5-Dehydro-4-deoxy-D-glucarate
            H2O
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
GENES       ECO: b2787(ygcX) b2788(ygcY)
            ECE: Z4102(ygcX) Z4103(ygcY) Z4104
            ECS: ECs3647 ECs3648
            BSU: BG11161(ycbF)
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
STRUCTURES  PDB: 1BQG  1EC7  1EC8  1EC9  1ECQ  1JCT  1JDF  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.40
            ExPASy - ENZYME nomenclature database: 4.2.1.40
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.40
            BRENDA, the Enzyme Database: 4.2.1.40
            SCOP (Structural Classification of Proteins): 4.2.1.40
///
ENTRY       EC 4.2.1.41
NAME        5-Dehydro-4-deoxyglucarate dehydratase
            5-Keto-4-deoxyglucarate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     5-Dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)
REACTION    5-Dehydro-4-deoxy-D-glucarate = 2,5-Dioxopentanoate + H2O + CO2
SUBSTRATE   5-Dehydro-4-deoxy-D-glucarate
PRODUCT     2,5-Dioxopentanoate
            H2O
            CO2
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
GENES       SME: SMa1440
            BSU: BG11158(ycbC)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.41
            ExPASy - ENZYME nomenclature database: 4.2.1.41
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.41
            BRENDA, the Enzyme Database: 4.2.1.41
///
ENTRY       EC 4.2.1.42
NAME        Galactarate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Galactarate hydro-lyase
REACTION    D-Galactarate = 5-Dehydro-4-deoxy-D-glucarate + H2O
SUBSTRATE   D-Galactarate
PRODUCT     5-Dehydro-4-deoxy-D-glucarate
            H2O
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
GENES       ECO: b3128(yhaG)
            ECE: Z4480(yhaG)
            ECS: ECs4006
            BSU: BG11163(ycbH)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.42
            ExPASy - ENZYME nomenclature database: 4.2.1.42
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.42
            BRENDA, the Enzyme Database: 4.2.1.42
///
ENTRY       EC 4.2.1.43
NAME        2-Dehydro-3-deoxy-L-arabinonate dehydratase
            2-Keto-3-deoxy-L-arabinonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Dehydro-3-deoxy-L-arabinonate hydro-lyase
REACTION    2-Dehydro-3-deoxy-L-arabinonate = 2,5-Dioxopentanoate + H2O
SUBSTRATE   2-Dehydro-3-deoxy-L-arabinonate
PRODUCT     2,5-Dioxopentanoate
            H2O
PATHWAY     PATH: MAP00053  Ascorbate and aldarate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.43
            ExPASy - ENZYME nomenclature database: 4.2.1.43
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.43
            BRENDA, the Enzyme Database: 4.2.1.43
///
ENTRY       EC 4.2.1.44
NAME        myo-Inosose-2 dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2,4,6/3,5-Pentahydroxycyclohexanone hydro-lyase
REACTION    2,4,6/3,5-Pentahydroxycyclohexanone =
            3,5/4-Trihydroxycyclohexa-1,2-dione + H2O
SUBSTRATE   2,4,6/3,5-Pentahydroxycyclohexanone
PRODUCT     3,5/4-Trihydroxycyclohexa-1,2-dione
            H2O
COFACTOR    Cobalt
            Manganese
COMMENT     Requires Co2+ or Mn2+.
PATHWAY     PATH: MAP00562  Inositol phosphate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.44
            ExPASy - ENZYME nomenclature database: 4.2.1.44
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.44
            BRENDA, the Enzyme Database: 4.2.1.44
///
ENTRY       EC 4.2.1.45
NAME        CDPglucose 4,6-dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     CDPglucose 4,6-hydro-lyase
REACTION    CDPglucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O
SUBSTRATE   CDPglucose
PRODUCT     CDP-4-dehydro-6-deoxy-D-glucose
            H2O
COFACTOR    NAD+
COMMENT     Requires bound NAD+.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       SME: SMb21417(ddhB)
            BSU: BG12978(yfnG)
            SYN: slr0984(rfbG)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.45
            ExPASy - ENZYME nomenclature database: 4.2.1.45
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.45
            BRENDA, the Enzyme Database: 4.2.1.45
///
ENTRY       EC 4.2.1.46
NAME        dTDPglucose 4,6-dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     dTDPglucose 4,6-hydro-lyase
REACTION    dTDPglucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O
SUBSTRATE   dTDPglucose
PRODUCT     dTDP-4-dehydro-6-deoxy-D-glucose
            H2O
COFACTOR    NAD+
COMMENT     Requires bound NAD+.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
            PATH: MAP00522  Erythromycin biosynthesis
GENES       ECO: b2041(rfbB) b3788(rffG)
            ECE: Z5299(rffG)
            ECS: ECs4721
            HIN: HI0873(rffG)
            PMU: PM1030(rffG)
            XFA: XF0255 XF0611
            PAE: PA5161(rmlB)
            NME: NMB0063 NMB0079
            NMA: NMA0189(rfbB2) NMA0204(rfbB)
            MLO: mll7879 mlr7552
            SME: SMb20239(rmlB) SMb20458 SMb21326(expA9)
            CCR: CC3629
            BSU: BG10618(spsJ)
            BHA: BH3364(spsJ)
            LLA: L199221(rmlB)
            SPY: SPy0936(cpsFQ)
            SPR: spr0322(cpsN)
            CAC: CAC2332(spsJ)
            MTU: Rv3464(rmlB) Rv3784(epiB)
            MTC: MT3570
            MLE: ML1964(rmlB)
            SYN: slr0809(rfbB) slr0836(rfbB)
            DRA: DRA0041
            MJA: MJ1055
            MTH: MTH1789 MTH373
            AFU: AF0324(rfbB)
            TVO: TVG0950610
            PHO: PH0414
            PAB: PAB0785(rfbB)
            APE: APE1180
            SSO: SSO0830(rfbB-1) SSO1734(rfbB-2) SSO1781(rfbB-3)
            CEL: D2096.4 F53B1.4
            DME: CG7979
            HSA: 23483(TDPGD)
STRUCTURES  PDB: 1BXK  1G1A  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.46
            ExPASy - ENZYME nomenclature database: 4.2.1.46
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.46
            BRENDA, the Enzyme Database: 4.2.1.46
            SCOP (Structural Classification of Proteins): 4.2.1.46
///
ENTRY       EC 4.2.1.47
NAME        GDPmannose 4,6-dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     GDPmannose 4,6-hydro-lyase
REACTION    GDPmannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O
SUBSTRATE   GDPmannose
PRODUCT     GDP-4-dehydro-6-deoxy-D-mannose
            H2O
COFACTOR    NAD+
COMMENT     The bacterial enzyme requires bound NAD+.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2053(gmd)
            ECE: Z3198 Z3217(gmd)
            ECS: ECs2839 ECs2858
            YPE: YPO3102(gmd)
            XFA: XF0609
            VCH: VC0243
            PAE: PA5453(gmd)
            HPY: HP0044(rfbD)
            HPJ: jhp0038
            MLO: mlr5849
            CCR: CC1010
            CAC: CAC2180
            MTU: Rv0112(gca) Rv1511(gmdA)
            MTC: MT0121 MT1561
            SYN: sll1212(rfbD)
            AAE: aq_1082(rfbD)
            CEL: C53B4.7 F56H6.5
            DME: CG8890
            HSA: 2762(GMDS)
STRUCTURES  PDB: 1DB3  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.47
            ExPASy - ENZYME nomenclature database: 4.2.1.47
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.47
            BRENDA, the Enzyme Database: 4.2.1.47
            SCOP (Structural Classification of Proteins): 4.2.1.47
///
ENTRY       EC 4.2.1.48
NAME        D-Glutamate cyclase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Glutamate hydro-lyase (cyclizing)
REACTION    D-Glutamate = 5-Oxo-D-proline + H2O
SUBSTRATE   D-Glutamate
PRODUCT     5-Oxo-D-proline
            H2O
COMMENT     Also acts on various derivatives of D-glutamate.
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.48
            ExPASy - ENZYME nomenclature database: 4.2.1.48
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.48
            BRENDA, the Enzyme Database: 4.2.1.48
///
ENTRY       EC 4.2.1.49
NAME        Urocanate hydratase
            Urocanase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     4,5-Dihydro-4-oxo-5-imidazolepropanoate hydro-lyase
REACTION    4,5-Dihydro-4-oxo-5-imidazolepropanoate = Urocanate + H2O
SUBSTRATE   4,5-Dihydro-4-oxo-5-imidazolepropanoate
PRODUCT     Urocanate
            H2O
COFACTOR    2-Oxobutanoate
COMMENT     Contains bound 2-oxobutanoate
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       YPE: YPO4017(hutU)
            VCH: VC1203
            PAE: PA5100(hutU)
            MLO: mlr8323
            SME: SMb21163(hutU)
            CCR: CC0957
            BSU: BG10668(hutU)
            BHA: BH1983(hutU)
            SAU: SA2122(hutU)
            SAV: SAV2316(hutU)
            SPY: SPy2082(hutU)
            DRA: DRA0151
            HAL: VNG1208G(hutU)
            TAC: Ta0239
            TVO: TVG1428912
MOTIF       PS: PS01233  F-Q-G-L-P-x-R-I-C-W
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.49
            ExPASy - ENZYME nomenclature database: 4.2.1.49
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.49
            BRENDA, the Enzyme Database: 4.2.1.49
///
ENTRY       EC 4.2.1.50
NAME        Pyrazolylalanine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Serine hydro-lyase (adding pyrazole)
REACTION    L-Serine + Pyrazole = 3-(Pyrazol-1-yl)-L-alanine + H2O
SUBSTRATE   L-Serine
            Pyrazole
PRODUCT     3-(Pyrazol-1-yl)-L-alanine
            H2O
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.50
            ExPASy - ENZYME nomenclature database: 4.2.1.50
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.50
            BRENDA, the Enzyme Database: 4.2.1.50
///
ENTRY       EC 4.2.1.51
NAME        Prephenate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Prephenate hydro-lyase (decarboxylating)
REACTION    Prephenate = Phenylpyruvate + H2O + CO2
SUBSTRATE   Prephenate
            Chorismate
PRODUCT     Phenylpyruvate
            H2O
            CO2
            Prephenate
COMMENT     This enzyme in the enteric bacteria also possesses chorismate
            mutase activity and converts chorismate into prephenate.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2599(pheA)
            ECE: Z3891(pheA)
            ECS: ECs3462
            YPE: YPO3281(pheA)
            HIN: HI1145(pheA)
            PMU: PM0150(pheA)
            XFA: XF2325
            VCH: VC0705
            PAE: PA3166(pheA)
            BUC: BU392(pheA)
            NME: NMB0446
            NMA: NMA2039(pheA)
            CJE: Cj0316(pheA)
            MLO: mlr5498
            SME: SMc02899(pheA)
            CCR: CC2933
            BSU: BG10914(pheA)
            BHA: BH1215(pheA)
            SAU: SA1731
            SAV: SAV1900(pheA)
            LLA: L0055(pheA)
            SPN: SP1369
            SPR: spr1227(pheA)
            CAC: CAC0217(pheA)
            MTU: Rv3838c(pheA)
            MTC: MT3946
            MLE: ML0078(pheA)
            SYN: sll1662(pheA)
            DRA: DR1147
            AAE: aq_951(pheA)
            TMA: TM0155
            MJA: MJ0637(pheA)
            MTH: MTH1220
            AFU: AF0227(pheA)
            HAL: VNG2222G(pheA)
            TAC: Ta0915
            TVO: TVG0891777
            SSO: SSO0246(pheA)
            STO: ST0294
            SCE: YNL316C(PHA2)
MOTIF       PS: PS00857  [FY]-x-[LIVM]-x(2)-[LIVM]-x(5)-[DN]-x(5)-T-R-F-[LIVMW]-
                         x-[LIVM]
            PS: PS00858  [LIVM]-[ST]-[KR]-[LIVM]-E-[ST]-R-P
            PS: PS01039  G-[FYIL]-[DE]-[LIVMT]-[DE]-[LIVMF]-x(3)-[LIVMA]-[VAGC]-
                         x(2)-[LIVMAGN]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.51
            ExPASy - ENZYME nomenclature database: 4.2.1.51
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.51
            BRENDA, the Enzyme Database: 4.2.1.51
///
ENTRY       EC 4.2.1.52
NAME        Dihydrodipicolinate synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Aspartate-4-semialdehyde hydro-lyase
            (adding pyruvate and cyclizing)
REACTION    L-Aspartate 4-semialdehyde + Pyruvate = 2,3-Dihydrodipicolinate +
            2 H2O
SUBSTRATE   L-Aspartate 4-semialdehyde
            Pyruvate
PRODUCT     2,3-Dihydrodipicolinate
            H2O
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b2478(dapA)
            ECE: Z3737(dapA)
            ECS: ECs3340
            YPE: YPO3062(dapA)
            HIN: HI0255(dapA)
            PMU: PM1051(dapA)
            XFA: XF0963
            VCH: VC2157
            PAE: PA0223 PA1010 PA1254
            BUC: BU096(dapA)
            NME: NMB0929
            NMA: NMA1124(dapA)
            HPY: HP1013(dapA)
            HPJ: jhp0410
            CJE: Cj0806(dapA)
            RPR: RP429(dapA)
            RCO: RC0595(dapA)
            MLO: mll3981 mll6376 mll6811 mlr6292 mlr7746
            SME: SMb20140(dapA2) SMb21508(dapA3) SMc02404(dapA1)
            CCR: CC1195
            BSU: BG10785(dapA)
            BHA: BH1742 BH2399(dapA)
            SAU: SA1227(dapA)
            SAV: SAV1380(dapA)
            LLA: L0093(dapA)
            SPN: SP1014
            SPR: spr0919(dapA)
            CAC: CAC2378(dapA) CAC3600(dapA)
            MTU: Rv2753c(dapA)
            MTC: MT2823
            MLE: ML1513(dapA)
            CTR: CT361
            CMU: TC0640
            CPN: CPn1050
            CPA: CP0802
            CPJ: dapA
            SYN: slr0550(dapA)
            AAE: aq_1143(dapA)
            TMA: TM1521
            MJA: MJ0244(dapA)
            MTH: MTH801
            AFU: AF0910(dapA)
            HAL: VNG0444G(dapA)
            TAC: Ta1157
            TVO: TVG1289977
            PHO: PH0847
            PAB: PAB0832(dapA)
            APE: APE1023
            SSO: SSO2274(dapA-1) SSO3035(dapA-2) SSO3072(dapA-3)
MOTIF       PS: PS00665  [GSA]-[LIVM]-[LIVMFY]-x(2)-G-[ST]-[TG]-G-E-[GASNF]-
                         x(6)-[EQ]
            PS: PS00666  Y-[DNS]-[LIVMFA]-P-x(2)-[ST]-x(3)-[LIVMF]-x(13,14)-
                         [LIVM]-x-[SGA]-[LIVMF]-K-[DEQAF]-[STAC]
STRUCTURES  PDB: 1DHP  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.52
            ExPASy - ENZYME nomenclature database: 4.2.1.52
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.52
            BRENDA, the Enzyme Database: 4.2.1.52
            SCOP (Structural Classification of Proteins): 4.2.1.52
///
ENTRY       EC 4.2.1.53
NAME        Oleate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (R)-10-Hydroxystearate 10-hydro-lyase
REACTION    (R)-10-Hydroxystearate = Oleate + H2O
SUBSTRATE   (R)-10-Hydroxystearate
PRODUCT     Oleate
            H2O
COMMENT     Acts on a number of 10-hydroxy acids.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.53
            ExPASy - ENZYME nomenclature database: 4.2.1.53
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.53
            BRENDA, the Enzyme Database: 4.2.1.53
///
ENTRY       EC 4.2.1.54
NAME        Lactoyl-CoA dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Lactoyl-CoA hydro-lyase
REACTION    Lactoyl-CoA = Acryloyl-CoA + H2O
SUBSTRATE   Lactoyl-CoA
PRODUCT     Acryloyl-CoA
            H2O
PATHWAY     PATH: MAP00640  Propanoate metabolism
            PATH: MAP00643  Styrene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.54
            ExPASy - ENZYME nomenclature database: 4.2.1.54
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.54
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.54
            BRENDA, the Enzyme Database: 4.2.1.54
///
ENTRY       EC 4.2.1.55
NAME        3-Hydroxbutyryl-CoA dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3R)-3-Hydroxybutanoyl-CoA hydro-lyase
REACTION    (3R)-3-Hydroxybutanoyl-CoA = Crotonoyl-CoA + H2O
SUBSTRATE   (3R)-3-Hydroxybutanoyl-CoA
PRODUCT     Crotonoyl-CoA
            H2O
COMMENT     Also acts on crotonoyl thioesters of pantetheine and acyl-carrier
            protein.
PATHWAY     PATH: MAP00650  Butanoate metabolism
GENES       CAC: CAC2712(crt)
            DRA: DR1151
MOTIF       PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.55
            ExPASy - ENZYME nomenclature database: 4.2.1.55
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.55
            BRENDA, the Enzyme Database: 4.2.1.55
///
ENTRY       EC 4.2.1.56
NAME        Itaconyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Citramalyl-CoA hydro-lyase
REACTION    Citramalyl-CoA = Itaconyl-CoA + H2O
SUBSTRATE   Citramalyl-CoA
PRODUCT     Itaconyl-CoA
            H2O
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.56
            ExPASy - ENZYME nomenclature database: 4.2.1.56
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.56
            BRENDA, the Enzyme Database: 4.2.1.56
///
ENTRY       EC 4.2.1.57
NAME        Isohexenylglutaconyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase
REACTION    3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA =
            3-(4-Methylpent-3-en-1-yl)-pent-2-enedioyl-CoA + H2O
SUBSTRATE   3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA
            Dimethylacryloyl-CoA
            Farnesoyl-CoA
PRODUCT     3-(4-Methylpent-3-en-1-yl)-pent-2-enedioyl-CoA
            H2O
COMMENT     Also acts on dimethylacryloyl-CoA and farnesoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.57
            ExPASy - ENZYME nomenclature database: 4.2.1.57
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.57
            BRENDA, the Enzyme Database: 4.2.1.57
///
ENTRY       EC 4.2.1.58
NAME        Crotonoyl-[acyl-carrier-protein] hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3R)-3-Hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase
REACTION    (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] =
            But-2-enoyl-[acyl-carrier protein] + H2O
SUBSTRATE   (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
PRODUCT     But-2-enoyl-[acyl-carrier protein]
            H2O
COMMENT     Is specific for short chain-length 3-hydroxyacyl-[acyl-carrier
            protein] derivatives (C4 to C8).
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.58
            ExPASy - ENZYME nomenclature database: 4.2.1.58
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.58
            BRENDA, the Enzyme Database: 4.2.1.58
///
ENTRY       EC 4.2.1.59
NAME        3-Hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3R)-3-Hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase
REACTION    (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein] =
            2-Octanoyl-[acyl-carrier protein] + H2O
SUBSTRATE   (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
PRODUCT     2-Octanoyl-[acyl-carrier protein]
            H2O
COMMENT     Is specific for 3-hydroxyacyl-[acyl-carrier protein] derivatives
            (C6 to C12).
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.59
            ExPASy - ENZYME nomenclature database: 4.2.1.59
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.59
            BRENDA, the Enzyme Database: 4.2.1.59
///
ENTRY       EC 4.2.1.60
NAME        3-Hydroxydecanoyl-[acyl-carrier-protein] dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3R)-3-Hydroxydecanoyl-[acyl-carrier-protein] hydro-lyase
REACTION    (3R)-3-Hydroxydecanoyl-[acyl-carrier protein] =
            2-Decanoyl-[acyl-carrier protein] or
            3-Decanoyl-[acyl-carrier protein] + H2O
SUBSTRATE   (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
PRODUCT     2-Decanoyl-[acyl-carrier protein]
            3-Decanoyl-[acyl-carrier protein]
            H2O
COMMENT     Specific for C10 chain length.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b0954(fabA)
            ECE: Z1304(fabA)
            ECS: ECs1038
            YPE: YPO1430(fabA)
            HIN: HI1325(fabA)
            PMU: PM0484(fabA)
            XFA: XF0572
            VCH: VC1483
            PAE: PA1610(fabA)
            MLO: mll5569
            SME: SMc00328(fabA)
            CCR: CC3720
STRUCTURES  PDB: 1MKA  1MKB  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.60
            ExPASy - ENZYME nomenclature database: 4.2.1.60
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.60
            BRENDA, the Enzyme Database: 4.2.1.60
            SCOP (Structural Classification of Proteins): 4.2.1.60
///
ENTRY       EC 4.2.1.61
NAME        3-Hydroxypalmitoyl-[acyl-carrier-protein] dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (3R)-3-Hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase
REACTION    (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein] =
            2-Hexadecenoyl-[acyl-carrier protein] + H2O
SUBSTRATE   (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
PRODUCT     2-Hexadecenoyl-[acyl-carrier protein]
            H2O
COMMENT     Is specific for 3-hydroxyacyl-[acyl-carrier protein] derivatives
            (C12 to C16) and has the highest activity on the C16 derivative.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       SCE: YKL182W(FAS1)
            SPO: SPAC926.09C(spac926.09c)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00606  G-x(4)-[LIVMFAP]-x(2)-[AGC]-C-[STA](2)-[STAG]-x(3)-
                         [LIVMF]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.61
            ExPASy - ENZYME nomenclature database: 4.2.1.61
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.61
            BRENDA, the Enzyme Database: 4.2.1.61
///
ENTRY       EC 4.2.1.62
NAME        5alpha-Hydroxysteroid dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     5alpha-Ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase
REACTION    5alpha-Ergosta-7,22-diene-3beta,5-diol = Ergosterol + H2O
SUBSTRATE   5alpha-Ergosta-7,22-diene-3beta,5-diol
PRODUCT     Ergosterol
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.62
            ExPASy - ENZYME nomenclature database: 4.2.1.62
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.62
            BRENDA, the Enzyme Database: 4.2.1.62
///
ENTRY       EC 4.2.1.63
NAME        Transferred to EC 3.3.2.3
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Transferred entry. Now EC 3.3.2.3 - Epoxide hydrolase.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.63
            ExPASy - ENZYME nomenclature database: 4.2.1.63
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.63
///
ENTRY       EC 4.2.1.64
NAME        Transferred to EC 3.3.2.3
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
COMMENT     Transferred entry. Now EC 3.3.2.3 - Epoxide hydrolase.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.64
            ExPASy - ENZYME nomenclature database: 4.2.1.64
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.64
///
ENTRY       EC 4.2.1.65
NAME        3-Cyanoalanine hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Asparagine hydro-lyase
REACTION    L-Asparagine = 3-Cyano-L-alanine + H2O
SUBSTRATE   L-Asparagine
PRODUCT     3-Cyano-L-alanine
            H2O
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.65
            ExPASy - ENZYME nomenclature database: 4.2.1.65
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.65
            BRENDA, the Enzyme Database: 4.2.1.65
///
ENTRY       EC 4.2.1.66
NAME        Cyanide hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Formamide hydro-lyase
REACTION    Formamide = Hydrogen cyanide + H2O
SUBSTRATE   Formamide
PRODUCT     Hydrogen cyanide
            H2O
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
MOTIF       PS: PS00920  G-x(2)-[LIVMFY](2)-x-[IF]-x-E-x(2)-[LIVM]-x-G-Y-P
            PS: PS00921  G-[GAQ]-x(2)-C-[WA]-E-[NH]-x(2)-[PST]-[LIVMFYS]-x-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.66
            ExPASy - ENZYME nomenclature database: 4.2.1.66
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.66
            BRENDA, the Enzyme Database: 4.2.1.66
///
ENTRY       EC 4.2.1.67
NAME        D-Fuconate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Fuconate hydro-lyase
REACTION    D-Fuconate = 2-Dehydro-2-deoxy-D-fuconate + H2O
SUBSTRATE   D-Fuconate
            L-Arabinonate
PRODUCT     2-Dehydro-2-deoxy-D-fuconate
            H2O
            2-Dehydro-3-deoxy-L-arabinonate
COMMENT     Also acts on L-arainonate.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.67
            ExPASy - ENZYME nomenclature database: 4.2.1.67
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.67
            BRENDA, the Enzyme Database: 4.2.1.67
///
ENTRY       EC 4.2.1.68
NAME        L-Fuconate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Fuconate hydro-lyase
REACTION    L-Fuconate = 2-Dehydro-3-deoxy-L-fuconate + H2O
SUBSTRATE   L-Fuconate
PRODUCT     2-Dehydro-3-deoxy-L-fuconate
            H2O
COMMENT     Also acts, slowly, on D-arabinonate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.68
            ExPASy - ENZYME nomenclature database: 4.2.1.68
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.68
            BRENDA, the Enzyme Database: 4.2.1.68
///
ENTRY       EC 4.2.1.69
NAME        Cyanamide hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Urea hydro-lyase
REACTION    Urea = Cyanamide + H2O
SUBSTRATE   Urea
PRODUCT     Cyanamide
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.69
            ExPASy - ENZYME nomenclature database: 4.2.1.69
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.69
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.69
            BRENDA, the Enzyme Database: 4.2.1.69
///
ENTRY       EC 4.2.1.70
NAME        Pseudouridylate synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Uracil hydro-lyase (adding D-ribose 5-phosphate)
REACTION    Uracil + D-Ribose 5-phosphate = Pseudouridine 5'-phosphate + H2O
SUBSTRATE   Uracil
            D-Ribose 5-phosphate
PRODUCT     Pseudouridine 5'-phosphate
            H2O
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b0058(rluA) b1086(rluC) b2183(rsuA) b2318(truA) b2594(rluD)
                 b3166(truB)
            ECE: Z0066(yabO) Z1725(yceC) Z3442(rsuA) Z3580(truA) Z3888(sfhB)
                 Z4527(truB)
            ECS: ECs0062 ECs1464 ECs3075 ECs3202 ECs3457 ECs4047
            YPE: YPO0497(rluA) YPO1266(rsuA) YPO1591(rluC) YPO2766(truA)
                 YPO3277(rluD) YPO3494(truB)
            HIN: HI0176(rluD) HI0412(rluC) HI0617(rluA) HI1243 HI1289(truB)
                 HI1644(truA)
            PMU: PM0003(rsuA_1) PM0637(truA) PM0756(truB) PM0992(rluC)
                 PM1719(sfB) PM1836(rsuA_2)
            XFA: XF0237 XF0939 XF1200 XF1373 XF2606
            VCH: VC0645 VC0709 VC0999 VC1635 VC2028 VC2505 VCA0104
            PAE: PA0733 PA2975(rluC) PA3114(truA) PA3246(rluA) PA4544(rluD)
                 PA4742(truB)
            BUC: BU199(truA) BU348(rluC) BU375(truB) BU401(rluD)
            NME: NMB0198 NMB0704 NMB1298 NMB1374 NMB2036
            NMA: NMA0070(rluC) NMA0402(truA) NMA0908(rluD) NMA1508
                 NMA1588(truB)
            HPY: HP0361(trua)
            HPJ: jhp1019
            CJE: Cj0022c Cj0708 Cj0827(truA) Cj1102(truB) Cj1280c Cj1709c
            RPR: RP258 RP501(truB) RP502 RP857(truA)
            RCO: RC0344(rluC) RC0665(truB) RC0807(rluB) RC1328(truA)
            MLO: mlr0334 mlr3740 mlr5558
            SME: SMc00321(truB) SMc00647(rluD) SMc01099(truA) SMc01275(rluC)
            ATU: AGR_C_127
            CCR: CC0036 CC0278 CC0453 CC1284 CC1980
            BSU: BG10271(truB) BG10530(rluB) BG11992(truA)
            BHA: BH0167(truA) BH1576(rluB) BH2410(truB) BH3273
            SAU: SA1114(truB) SA1324(rluB) SA1574 SA2018(truA)
            SAV: SAV1259(truB) SAV1482(rluB) SAV1739 SAV2205(truA)
            LLA: L0328(truB) L0331(truA) L109527(rsuA) L25787(rluD)
            SPY: SPy1251(truB) SPy1337(rsuA) SPy1901(truA)
            SPN: SP0280 SP1212 SP1599 SP1874
            SPR: spr0256(rsuA) spr1092(truB) spr1451(truA)
            CAC: CAC1015 CAC1805(truB) CAC2676 CAC3099(truA)
            MGE: MG182(trua)
            MPN: GT9_orf243(hisT)
            MPU: MYPU_1170(rluC) MYPU_2980(rluD) MYPU_3370(rluB)
                 MYPU_5500(truB)
            UUR: UU113(sfhB) UU313(rluD) UU354(truB) UU536(hisT)
            MTU: Rv1540 Rv2793c Rv3455c(truA)
            MTC: MT1592 MT2862.1 MT3562
            MLE: ML1200 ML1546(truB) ML1955(truA)
            CTR: CT094 CT463 CT658 CT723
            CMU: TC0029 TC0096 TC0369 TC0748
            CPN: CPn0319 CPn0580 CPn0719 CPn0864
            CPA: CP0027 CP0168 CP0438 CP1005
            CPJ: sfhB truA truB yjbC
            BBU: BB0012(hisT) BB0018 BB0803(truB)
            TPA: TP0830 TP0889
            SYN: sll1820(truA) slr0457(truB)
            DRA: DR0896 DR0961 DR1323 DR1789 DR2290
            AAE: aq_554 aq_705(truB) aq_749(truA)
            TMA: TM0264 TM0856 TM0940 TM1574
            MJA: MJ0148(cbf5) MJ1675(truA)
            MTH: MTH32 MTH840
            AFU: AF0238(cbf5) AF1730(truA)
            HAL: VNG1729G(sus) VNG2003G(truA)
            TAC: Ta0932
            TVO: TVG1128771
            PHO: PH1242 PH1644
            PAB: PAB0356(trub) PAB1701(truA)
            APE: APE0989 APE0990
            SSO: SSO0393(truB) SSO5761(truB)
            STO: ST0402 STS055
            SCE: YFL001W(DEG1) YGL063W(PUS2) YNL292W(PUS4) YPL212C(PUS1)
            SPO: SPAC25B8.05(spac25b8.05)
            ATH: At2g30320(T9D9.13)
            CEL: E02H1.3
            DME: CG3045
MOTIF       PS: PS01129  [LIVCA]-[NHYT]-R-[LI]-D-x(2)-T-[STA]-G-[LIVAGC]-
                         [LIVMF](2)-[LIVMFGC]-[SGTACV]
            PS: PS01149  G-R-L-D-x(2)-[STA]-x-G-[LIVFA]-[LIVMF](3)-[ST]-[DNST]
STRUCTURES  PDB: 1DJ0  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.70
            ExPASy - ENZYME nomenclature database: 4.2.1.70
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.70
            BRENDA, the Enzyme Database: 4.2.1.70
            SCOP (Structural Classification of Proteins): 4.2.1.70
///
ENTRY       EC 4.2.1.71
NAME        Acetylenecarboxylate hydratase
            Acetylenemonocarboxylate hydratase
            Alkynoate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3-Hydroxypropenoate hydro-lyase
REACTION    3-Hydroxypropenoate = Propynoate + H2O
SUBSTRATE   3-Hydroxypropenoate
            Acetoacetate
PRODUCT     Propynoate
            H2O
            3-Gutynoate
COMMENT     The reaction is effectively irreversible, favouring the tautomers
            of malonic semialdehyde. Also acts on 3-butynoate (in the reverse
            direction), forming acetoacetate.
PATHWAY     PATH: MAP00640  Propanoate metabolism
            PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.71
            ExPASy - ENZYME nomenclature database: 4.2.1.71
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.71
            BRENDA, the Enzyme Database: 4.2.1.71
///
ENTRY       EC 4.2.1.72
NAME        Acetylenedicarboxylate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Hydroxyethylenedicarboxylate hydro-lyase
REACTION    2-Hydroxyethylenedicarboxylate = Acetylenedicarboxylate + H2O
SUBSTRATE   2-Hydroxyethylenedicarboxylate
PRODUCT     Acetylenedicarboxylate
            H2O
COMMENT     Hydrates acetylenedicarboxylate to pyruvate + CO2.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.72
            ExPASy - ENZYME nomenclature database: 4.2.1.72
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.72
            BRENDA, the Enzyme Database: 4.2.1.72
///
ENTRY       EC 4.2.1.73
NAME        Protoaphin-aglucone dehydratase (cyclizing)
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Protoaphin-aglucone hydro-lyase (cyclizing)
REACTION    Protoaphin aglucone = Xanthoaphin + H2O
SUBSTRATE   Protoaphin aglucone
PRODUCT     Xanthoaphin
            H2O
COMMENT     The product is converted non-enzymically to erythroaphin, an aphid
            pigment.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.73
            ExPASy - ENZYME nomenclature database: 4.2.1.73
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.73
            BRENDA, the Enzyme Database: 4.2.1.73
///
ENTRY       EC 4.2.1.74
NAME        Long-chain-enoyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase
REACTION    (3S)-3-Hydroxyacyl-CoA = trans-2-Enoyl-CoA + H2O
SUBSTRATE   (3S)-3-Hydroxyacyl-CoA
PRODUCT     trans-2-Enoyl-CoA
            H2O
COMMENT     Acts in the reverse direction. The best substrate is oct-3-enoyl-
            -CoA. Unlike EC 4.2.1.17 does not act on crotonoyl-CoA.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.74
            ExPASy - ENZYME nomenclature database: 4.2.1.74
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.74
            BRENDA, the Enzyme Database: 4.2.1.74
///
ENTRY       EC 4.2.1.75
NAME        Uroporphyrinogen-III synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Hydroxymethylbilane hydro-lyase(cyclizing)
REACTION    Hydroxymethylbilane = Uroporphyrinogen III + H2O
SUBSTRATE   Hydroxymethylbilane
PRODUCT     Uroporphyrinogen III
            H2O
COMMENT     In the presence of EC 4.3.1.8, forms uroporphyrinogen III from
            Porphobillinogen. (EC 4.3.1.8 Porphobillinogen deaminase)
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b3804(hemD)
            ECE: Z5318(hemD)
            ECS: ECs4734
            YPE: YPO3850(hemD)
            PMU: PM1813(hemX)
            XFA: XF1799
            VCH: VC0119
            PAE: PA5259(hemD)
            NME: NMB0777
            NMA: NMA0988
            HPY: HP1224(hemD)
            HPJ: jhp1145
            SME: SMc03232(hemD)
            BSU: BG10343(hemD)
            BHA: BH3045(hemD)
            SAU: SA1493(hemD)
            SAV: SAV1653
            MTU: Rv0511(cysG)
            MTC: MT0532
            MLE: ML2420(hemD)
            SYN: sll0166(hemD)
            DRA: DR0786 DRA0011
            MJA: MJ0994(hemD)
            MTH: MTH166
            AFU: AF0116(hemD)
            HAL: VNG2332G(cysG)
            SSO: SSO0184
            STO: ST0218
            SCE: YOR278W(HEM4)
            SPO: UPS(ups)
            DME: CG1885 CG9589
            HSA: 7390(UROS)
DISEASE     MIM: 263700  Uroporphyrinogen III synthase
MOTIF       PS: PS00839  [LIVM]-[GS]-[STAL]-G-P-G-x(3)-[LIVMFY]-[LIVM]-T-[LIVM]-
                         [KRHQG]-[AG]
            PS: PS00840  V-x(2)-[LI]-x(2)-G-D-x(3)-[FYW]-[GS]-x(8)-[LIVF]-
                         x(5,6)-[LIVMFYWPAC]-x-[LIVMY]-x-P-G
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.75
            ExPASy - ENZYME nomenclature database: 4.2.1.75
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.75
            BRENDA, the Enzyme Database: 4.2.1.75
///
ENTRY       EC 4.2.1.76
NAME        UDPglucose 4,6-dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     UDPglucose 4,6-hydro-lyase
REACTION    UDPglucose = UDP-4-dehydro-6-deoxy-D-glucose + H2O
SUBSTRATE   UDPglucose
PRODUCT     UDP-4-dehydro-6-deoxy-D-glucose
            H2O
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.76
            ExPASy - ENZYME nomenclature database: 4.2.1.76
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.76
            BRENDA, the Enzyme Database: 4.2.1.76
///
ENTRY       EC 4.2.1.77
NAME        trans-L-3-Hydroxyproline dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     trans-L-3-Hydroxyproline hydro-lyase
REACTION    trans-L-3-Hydroxyproline = delta1-Pyrroline 2-carboxylate
SUBSTRATE   trans-L-3-Hydroxyproline
PRODUCT     delta1-Pyrroline 2-carboxylate
COMMENT     Highly specific. 2,3-Dehydroproline is an intermediate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.77
            ExPASy - ENZYME nomenclature database: 4.2.1.77
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.77
            BRENDA, the Enzyme Database: 4.2.1.77
///
ENTRY       EC 4.2.1.78
NAME        (S)-Norlaudanosoline synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     3,4-Dihydroxyphenylacetaldehyde hydro-lyase (adding dopamine)
REACTION    2-(3,4-Dihydroxyphenyl)ethylamine +
            3,4-Dihydroxyphenylacetaldehyde = (S)-Norlaudanosoline + H2O
SUBSTRATE   2-(3,4-Dihydroxyphenyl)ethylamine
            3,4-Dihydroxyphenylacetaldehyde
PRODUCT     (S)-Norlaudanosoline
            H2O
COMMENT     The product is the precursor of the benzylisoquinoline alkaloids.
PATHWAY     PATH: MAP00950  Alkaloid biosynthesis I
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.78
            ExPASy - ENZYME nomenclature database: 4.2.1.78
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.78
            BRENDA, the Enzyme Database: 4.2.1.78
///
ENTRY       EC 4.2.1.79
NAME        2-Methylcitrate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Hydroxybutane-1,2,3-tricarboxylate hydro-lyase
REACTION    2-Hydroxybutane-1,2,3-tricarboxylate =
            (Z)-But-2-ene-1,2,3-tricarboxylate + H2O
SUBSTRATE   2-Hydroxybutane-1,2,3-tricarboxylate
PRODUCT     (Z)-But-2-ene-1,2,3-tricarboxylate
            H2O
COMMENT     Not identical with EC 4.2.1.4.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.79
            ExPASy - ENZYME nomenclature database: 4.2.1.79
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.79
            BRENDA, the Enzyme Database: 4.2.1.79
///
ENTRY       EC 4.2.1.80
NAME        2-Oxopent-4-enoate hydratase
            2-Keto-4-pentenoate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     4-Hydroxy-2-oxopentanoate hydro-lyase
REACTION    4-Hydroxy-2-oxopentanoate = 2-Oxopent-4-enoate + H2O
SUBSTRATE   4-Hydroxy-2-oxopentanoate
PRODUCT     2-Oxopent-4-enoate
            H2O
COMMENT     Also acts, more slowly, on cis-2-oxohex-4-enoate, but not on the
            trans-isomer.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00621  Biphenyl degradation
            PATH: MAP00622  Toluene degradation
            PATH: MAP00626  Nitorobenzene degradation
            PATH: MAP00627  1,4-Dichlorobenzene degradation
            PATH: MAP00628  Fluorene degradation
            PATH: MAP00629  Carbazole degradation
            PATH: MAP00642  Ethylbenzene degradation
            PATH: MAP00643  Styrene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.80
            ExPASy - ENZYME nomenclature database: 4.2.1.80
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.80
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.80
            BRENDA, the Enzyme Database: 4.2.1.80
///
ENTRY       EC 4.2.1.81
NAME        D(-)-Tartrate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (S,S)-Tartrate hydro-lyase
REACTION    (S,S)-Tartaric acid = Oxaloacetate + H2O
SUBSTRATE   (S,S)-Tartaric acid
PRODUCT     Oxaloacetate
            H2O
COFACTOR    Iron
            Manganese
COMMENT     Requires Fe2+ or Mn2+. cf. EC 4.2.1.32.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.81
            ExPASy - ENZYME nomenclature database: 4.2.1.81
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.81
            BRENDA, the Enzyme Database: 4.2.1.81
///
ENTRY       EC 4.2.1.82
NAME        Xylonate dehydratase
            D-xylo-Aldonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     D-Xylonate hydro-lyase
REACTION    D-Xylonate = 2-Dehydro-3-deoxy-D-xylonate + H2O
SUBSTRATE   D-Xylonate
PRODUCT     2-Dehydro-3-deoxy-D-xylonate
            H2O
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.82
            ExPASy - ENZYME nomenclature database: 4.2.1.82
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.82
            BRENDA, the Enzyme Database: 4.2.1.82
///
ENTRY       EC 4.2.1.83
NAME        4-Oxalmesaconate hydratase
            4-Carboxy-2-oxohexenedioate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase
REACTION    2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate =
            (E)-4-Oxobut-1-ene-1,2,4-tricarboxylate + H2O
SUBSTRATE   2-Hydroxy-4-oxobutane-1,2,4-tricarboxylate
PRODUCT     (E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.83
            ExPASy - ENZYME nomenclature database: 4.2.1.83
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.83
            BRENDA, the Enzyme Database: 4.2.1.83
///
ENTRY       EC 4.2.1.84
NAME        Nitrile hydratase
            Nitrilase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Nitrile hydro-lyase
REACTION    an Aliphatic amide = a Nitrile + H2O
SUBSTRATE   Aliphatic amide
            Alkylnitrile
            Acrylonitrile
            H2O
            4-Cyanopyridine
            2-Cyanopyridine
            Cyanopyrazine
PRODUCT     Nitrile
            H2O
            Alkylamide
            Acrylamide
            Isonicotineamide
            Picolinamide
            Pyrazinamide
INHIBITOR   Phenylhydrazine
            Semicarbazide
            Isobutyronitrile
COFACTOR    Iron
            Cobalt
            Pyrroloquinoline quinone
COMMENT     Acts on short-chain aliphatic nitriles, converting them into the
            corresponding acid amides. Does not act on these amides or on
            aromatic nitriles. (cf. EC 3.5.5.1)
            Enzyme from Pseudomonas and Brevibacterium contains non-heme iron
            (low-spin Fe-III) and PQQ, but enzyme from Rhodococcus contains
            cobalt and PQQ.  Cobalt enzyme acts on aromatic nitriles, but
            iron enzyme does not.
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00643  Styrene degradation
GENES       SME: SMc01423(nthB) SMc01424(nthA)
STRUCTURES  PDB: 1AHJ  2AHJ  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.84
            ExPASy - ENZYME nomenclature database: 4.2.1.84
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.84
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.84
            BRENDA, the Enzyme Database: 4.2.1.84
            SCOP (Structural Classification of Proteins): 4.2.1.84
///
ENTRY       EC 4.2.1.85
NAME        Dimethylmaleate hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (2R,3S)-2,3-Dimethylmalate hydro-lyase
REACTION    (2R,3S)-2,3-Dimethylmalate = Dimethylmaleate + H2O
SUBSTRATE   (2R,3S)-2,3-Dimethylmalate
PRODUCT     Dimethylmaleate
            H2O
COFACTOR    Iron
COMMENT     Requires Fe2+. Inhibited by oxygen.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.85
            ExPASy - ENZYME nomenclature database: 4.2.1.85
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.85
            BRENDA, the Enzyme Database: 4.2.1.85
///
ENTRY       EC 4.2.1.86
NAME        16-Dehydroprogesterone hydratase
            16alpha-Hydroxyprogesterone dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     16alpha-Hydroxyprogesterone hydro-lyase
REACTION    16alpha-Hydroxyprogesterone = 16-Dehydroprogesterone + H2O
SUBSTRATE   16alpha-Hydroxyprogesterone
PRODUCT     16-Dehydroprogesterone
            H2O
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.86
            ExPASy - ENZYME nomenclature database: 4.2.1.86
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.86
            BRENDA, the Enzyme Database: 4.2.1.86
///
ENTRY       EC 4.2.1.87
NAME        Octopamine dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Octopamine hydro-lyase (deaminating)
REACTION    1-(4-Hydroxyphenyl)-2-aminoethanol =
            (4-Hydroxyphenyl)acetaldehyde + NH3 + H2O
SUBSTRATE   1-(4-Hydroxyphenyl)-2-aminoethanol
PRODUCT     (4-Hydroxyphenyl)acetaldehyde
            NH3
            H2O
COMMENT     The enzyme-catalysed reaction is believed to be dehydration to an
            enamine, which is spontaneously hydrolysed to an aldehyde and
            ammonia.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.87
            ExPASy - ENZYME nomenclature database: 4.2.1.87
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.87
            BRENDA, the Enzyme Database: 4.2.1.87
///
ENTRY       EC 4.2.1.88
NAME        Synephrine dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     1-(4-Hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase
            $ (methylamine-forming)
REACTION    1-(4-Hydroxyphenyl)-2-(methylamine)ethanol =
            (4-Hydroxyphenyl)acetaldehyde + Methylamine
SUBSTRATE   1-(4-Hydroxyphenyl)-2-(methylamine)ethanol
PRODUCT     (4-Hydroxyphenyl)acetaldehyde
            Methylamine
COMMENT     Removal of H2O from (+/-)-synephrine produces a 2,3-enamine,
            which hydrolyses to the products shown in the reaction above.
            The enzyme from Arthrobacter synephrinum is highly specific.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.88
            ExPASy - ENZYME nomenclature database: 4.2.1.88
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.88
            BRENDA, the Enzyme Database: 4.2.1.88
///
ENTRY       EC 4.2.1.89
NAME        Carnitine dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Carnitine hydro-lyase
REACTION    L-Carnitine = 4-(Trimethylammonio)but-2-enoate + H2O
SUBSTRATE   L-Carnitine
PRODUCT     4-(Trimethylammonio)but-2-enoate
            H2O
GENES       ECO: b0038(caiB)
            ECE: Z0044(caiB)
            ECS: ECs0041
            AFU: AF0020(caiB-1) AF0990(caiB-2)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.89
            ExPASy - ENZYME nomenclature database: 4.2.1.89
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.89
            BRENDA, the Enzyme Database: 4.2.1.89
///
ENTRY       EC 4.2.1.90
NAME        L-Rhamnonate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Rhamnonate hydro-lyase
REACTION    L-Rhamnonate = 2-Dehydro-3-deoxy-L-rhamnonate + H2O
SUBSTRATE   L-Rhamnonate
PRODUCT     2-Dehydro-3-deoxy-L-rhamnonate
            H2O
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.90
            ExPASy - ENZYME nomenclature database: 4.2.1.90
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.90
            BRENDA, the Enzyme Database: 4.2.1.90
///
ENTRY       EC 4.2.1.91
NAME        Carboxycyclohexadienyl dehydratase
            Arogenate dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     L-Arogenate hydro-lyase (decarboxylating)
REACTION    L-Arogenate = L-Phenylalanine + H2O + CO2
SUBSTRATE   L-Arogenate
            Prephenate
            D-Prephenyllactate
PRODUCT     L-Phenylalanine
            H2O
            CO2
            Phenylpyruvate
COMMENT     Also acts on prephenate and D-prephenyllactate. cf. EC 4.2.1.51.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.91
            ExPASy - ENZYME nomenclature database: 4.2.1.91
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.91
            BRENDA, the Enzyme Database: 4.2.1.91
///
ENTRY       EC 4.2.1.92
NAME        Hydroperoxide dehydratase
            Hydroperoxide isomerase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (9Z,11E,14Z)-(13S)-Hydroperoxyoctadeca-(9,11,14)-trienoate
            $ 12,13-hydro-lyase
REACTION    (9Z,11E,14Z)-(13S)-Hydroperoxyoctadeca-(9,11,14)-trienoate =
            (9Z)-(13S)-12,13-Epoxyoctadeca-9,11-dienoate + H2O
SUBSTRATE   (9Z,11E,14Z)-(13S)-Hydroperoxyoctadeca-(9,11,14)-trienoate
PRODUCT     (9Z)-(13S)-12,13-Epoxyoctadeca-9,11-dienoate
            H2O
COMMENT     Acts on a number of unsaturated fatty-acid hydroperoxides,
            forming the corresponding allene oxides.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.92
            ExPASy - ENZYME nomenclature database: 4.2.1.92
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.92
            BRENDA, the Enzyme Database: 4.2.1.92
///
ENTRY       EC 4.2.1.93
NAME        ATP-dependent H(4)NAD(P)OH dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     (6S)-beta-6-Hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-
            $dinucleotide hydro-lyase (ATP-hydrolysing)
REACTION    ATP + (6S)-6-beta-Hydroxy-1,4,5,6-tetrahydronicotinamide-adenine
            $ dinucleotide = ADP + Orthophosphate + NADH
SUBSTRATE   ATP
            (6S)-6-beta-Hydroxy-1,4,5,6-tetrahydronicotinamide-adenine
            $ dinucleotide
            (6S)-6-beta-Hydroxy-1,4,5,6-tetrahydronicotinamide-adenine
            $ dinucleotide 2'-phosphate
PRODUCT     ADP
            Orthophosphate
            NADH
            NADPH
COMMENT     Also acts on hydrated NADPH.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.93
            ExPASy - ENZYME nomenclature database: 4.2.1.93
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.93
            BRENDA, the Enzyme Database: 4.2.1.93
///
ENTRY       EC 4.2.1.94
NAME        Scytalone dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Scytalone 7,8-hydro-lyase
REACTION    Scytalone = 1,3,8-Trihydroxynaphthalene + H2O
SUBSTRATE   Scytalone
PRODUCT     1,3,8-Trihydroxynaphthalene
            H2O
COMMENT     Involved with EC 1.3.1.50 in the biosynthesis of melanin in
            pathogenic fungi.
STRUCTURES  PDB: 1STD  2STD  3STD  4STD  5STD  6STD  7STD  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.94
            ExPASy - ENZYME nomenclature database: 4.2.1.94
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.94
            BRENDA, the Enzyme Database: 4.2.1.94
            SCOP (Structural Classification of Proteins): 4.2.1.94
///
ENTRY       EC 4.2.1.95
NAME        Kievitone hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Kievitone-hydrate hydro-lyase
REACTION    Kievitone hydrate = Kievitone + H2O
SUBSTRATE   Kievitone hydrate
PRODUCT     Kievitone
            H2O
COMMENT     The enzyme from Fusarium sp. hydrates the methylbutenyl sidechain
            of the isoflavonoid phytoalexins, thus reducing their toxicity.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.95
            ExPASy - ENZYME nomenclature database: 4.2.1.95
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.95
            BRENDA, the Enzyme Database: 4.2.1.95
///
ENTRY       EC 4.2.1.96
NAME        Tetrahydrobiopterin dehydratase
            Pterin-4-alpha-carbinolamide dehydratase
            4-alpha-Hydroxy-tetrahydropterin dehydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
REACTION    2-Amino-4-oxo-4-alpha-hydroxy-6-(erythro-1',2',3'-Tri-
            $hydroxypropyl)-5,6,7,8-tetrahydroxypterin = 2-Amino-4-oxo-
            $6-(1',2',3'-trihydroxypropyl)-diquinoid-7,8-dihydroxypterin
            + H2O
SUBSTRATE   2-Amino-4-oxo-4-alpha-hydroxy-6-(erythro-1',2',3'-Tri-
            $hydroxypropyl)-5,6,7,8-tetrahydroxypterin
PRODUCT     2-Amino-4-oxo-6-(1',2',3'-trihydroxypropyl)-diquinoid-
            $7,8-dihydroxypterin
            H2O
COMMENT     Catalyses the dehydratation of 4-alpha-Hydroxy-tetrahydro-
            pterines.
GENES       VCH: VCA0827
            PAE: PA0871(phhB)
            MLO: mlr4350
            SME: SMc03834(pcbD)
            CCR: CC0245
            MTC: MT1196
            MLE: ML1503A
            SYN: ssl2296(dcoH)
            AAE: aq_049(phhB)
            HAL: VNG1773G(cad)
            SSO: SSO2187
            DME: CG1963(Pcd)
            HSA: 5092(PCBD)
DISEASE     MIM: 126090  Pterin-4a-carbinolamine dehydratase (dimerization
                         cofactor of hepatic
STRUCTURES  PDB: 1DCO  1DCP  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.96
            ExPASy - ENZYME nomenclature database: 4.2.1.96
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.96
            SCOP (Structural Classification of Proteins): 4.2.1.96
///
ENTRY       EC 4.2.1.97
NAME        Phaseollidin hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
REACTION    Phaseollidin hydrate = Phaseollidin + H2O
SUBSTRATE   Phaseollidin hydrate
PRODUCT     Phaseollidin
            H2O
COMMENT     The enzyme from F.solani which is distinct from Kievitone
            hydratase (EC 4.2.1.95) hydrates the methylbutenyl side-
            chain of the Isoflavonoid phytoalexin, Pheseollidin.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.97
            ExPASy - ENZYME nomenclature database: 4.2.1.97
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.97
///
ENTRY       EC 4.2.1.98
NAME        16-alpha-Hydroxyprogesterone dehydratase
            Hydroxyprogesterone dehydroxylase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
REACTION    16-alpha-Hydroxyprogesterone = 16,17-Didehydroprogesterone + H2O;
            16-alpha-Hydroxypregnenolone = 16,17-Didehydropregnenolone + H2O;
SUBSTRATE   16-alpha-Hydroxyprogesterone
            16-alpha-Hydroxypregnenolone
PRODUCT     16,17-Didehydroprogesterone
            H2O
            16,17-Didehydropregnenolone
COMMENT     16-alpha-hydroxypregnenolone is also a substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.98
            ExPASy - ENZYME nomenclature database: 4.2.1.98
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.98
///
ENTRY       EC 4.2.1.99
NAME        2-Methylisocitrate dehydratase
            (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate hydro-lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
REACTION    (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate =
            (Z)-But-2-ene-1,2,3-tricarboxylate + H2O
SUBSTRATE   (2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
PRODUCT     (Z)-But-2-ene-1,2,3-tricarboxylate
            H2O
COMMENT     The enzyme from the fungus Yarrowia lipolytica does not act on
            isocitrate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.99
            ExPASy - ENZYME nomenclature database: 4.2.1.99
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.99
///
ENTRY       EC 4.2.1.100
NAME        Cyclohexa-1,5-dienecarbonyl-CoA hydratase
            Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase
            Dienoyl-CoA hydratase
CLASS       Lyases
            Carbon-oxygen lyases
            Hydro-lyases
SYSNAME     Cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase
REACTION    Cyclohexa-1,5-dienecarbonyl-CoA + H2O = 6-Hydroxycyclohex-1-
            enecarbonyl-CoA
SUBSTRATE   Cyclohexa-1,5-dienecarbonyl-CoA
            H2O
PRODUCT     6-Hydroxycyclohex-1-enecarbonyl-CoA
COMMENT     The second enzyme of the central benzoyl-CoA pathway of anaerobic
            metabolism in Thauera aromatica.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.1.100
            ExPASy - ENZYME nomenclature database: 4.2.1.100
            WIT (What Is There) Metabolic Reconstruction: 4.2.1.100
            UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.100
///
ENTRY       EC 4.2.2.1
NAME        Hyaluronate lyase
            Hyaluronidase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Hyaluronate lyase
REACTION    Hyaluronate =
            n 3-(4-Deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
SUBSTRATE   Hyaluronate
            Chondroitin
PRODUCT     3-(4-Deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine
COMMENT     Also acts on chondroitin. Formerly EC 4.2.99.1.
GENES       SAU: SA2003(hysA)
            SAV: SAV2188(hysA)
            SPN: SP0314
            SPR: spr0286(hysA)
MOTIF       PS: PS00343  L-P-x-T-G-[STGAVDE]
STRUCTURES  PDB: 1C82  1EGU  1F9G  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.1
            ExPASy - ENZYME nomenclature database: 4.2.2.1
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.1
            BRENDA, the Enzyme Database: 4.2.2.1
            SCOP (Structural Classification of Proteins): 4.2.2.1
///
ENTRY       EC 4.2.2.2
NAME        Pectate lyase
            Pectate transeliminase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Poly(1,4-alpha-D-galacturonide)lyase
REACTION    Eliminative cleavage of pectate to give oligosaccharides with
            4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing
            ends.
SUBSTRATE   Pectate
            Polygalacturonide
PRODUCT     Oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl group
COMMENT     Also acts on other polygalacturonides. Does not act on pectin.
            Formerly EC 4.2.99.3.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       YPE: YPO3994(pelY)
            SME: SMb21239
            BSU: BG10840(pel)
            BHA: BH0698
            TMA: TM0433
STRUCTURES  PDB: 2PEC  2BSP  1AIR  1BN8  1EE6  1PCL  1PLU  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.2
            ExPASy - ENZYME nomenclature database: 4.2.2.2
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.2
            BRENDA, the Enzyme Database: 4.2.2.2
            SCOP (Structural Classification of Proteins): 4.2.2.2
///
ENTRY       EC 4.2.2.3
NAME        Poly(beta-D-mannuronate) lyase
            Alginate lyase I
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Poly(beta-D-1,4-mannuronide) lyase
REACTION    Eliminative cleavage of polysaccharides containing
            beta-D-mannuronate residues to give oligosaccharides with
            4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their
            ends
SUBSTRATE   (beta-D-Mannuronate)n
PRODUCT     4-Deoxy-alpha-L-erythro-hex-4-enopyranuronoside
COMMENT     Formerly EC 4.2.99.4.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       PAE: PA3547(algL)
STRUCTURES  PDB: 1HV6  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.3
            ExPASy - ENZYME nomenclature database: 4.2.2.3
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.3
            BRENDA, the Enzyme Database: 4.2.2.3
///
ENTRY       EC 4.2.2.4
NAME        Chondroitin ABC lyase
            Chondroitinase
            Chondroitin ABC eliminase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Chondroitin ABC lyase
REACTION    Eliminative degradation of polysaccharides containing
            1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or
            1,3-alpha-L-iduronosyl linkage to disaccharides containing
            4-deoxy-beta-D-gluc-4-enuronosyl groups
SUBSTRATE   Chondroitin 4-sulfate
            Chondroitin 6-sulfate
            Dermatan sulfate
COMMENT     Acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan
            sulfate, and slowly on hyaluronate. Formerly EC 4.2.99.6.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.4
            ExPASy - ENZYME nomenclature database: 4.2.2.4
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.4
            BRENDA, the Enzyme Database: 4.2.2.4
///
ENTRY       EC 4.2.2.5
NAME        Chondroitin AC lyase
            Chondroitinase
            Chondroitin sulfate lyase
            Chondroitin AC eliminase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Chondroitin AC lyase
REACTION    Eliminative degradation of polysaccharides containing
            1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to
            disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
SUBSTRATE   Chondroitin 4-sulfate
            Chondroitin 6-sulfate
COMMENT     Acts on chondroitin 4-sulfate and chondroitin 6-sulfate but less
            well on hyaluronate. Formerly EC 4.2.99.6.
STRUCTURES  PDB: 1HMU  1CB8  1HM2  1HM3  1HMW  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.5
            ExPASy - ENZYME nomenclature database: 4.2.2.5
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.5
            BRENDA, the Enzyme Database: 4.2.2.5
            SCOP (Structural Classification of Proteins): 4.2.2.5
///
ENTRY       EC 4.2.2.6
NAME        Oligogalacturonide lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Oligogalacturonide lyase
REACTION    4-(4-Deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate =
            2 5-Dehydro-4-deoxy-D-glucuronate
SUBSTRATE   4-(4-Deoxy-beta-D-gluc-4-enuronosyl)-D-galacturonate
PRODUCT     5-Dehydro-4-deoxy-D-glucuronate
COMMENT     Catalyses eliminative removal of unsaturated terminal residues
            also from oligosaccharides of D-galacturonate.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       YPE: YPO1713(ogl)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.6
            ExPASy - ENZYME nomenclature database: 4.2.2.6
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.6
            BRENDA, the Enzyme Database: 4.2.2.6
///
ENTRY       EC 4.2.2.7
NAME        Heparin lyase
            Heparin eliminase
            Heparinase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Heparin lyase
REACTION    Eliminative cleavage of polysaccharides containing 1,4-linked
            D-glucuronate or L-iduronate residues and 1,4-alpha-linked
            2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give
            oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl
            groups at their non-reducing ends.
SUBSTRATE   Heparin
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.7
            ExPASy - ENZYME nomenclature database: 4.2.2.7
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.7
            BRENDA, the Enzyme Database: 4.2.2.7
///
ENTRY       EC 4.2.2.8
NAME        Heparitin-sulfate lyase
            Heparin-sulfate eliminase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Heparin-sulfate lyase
REACTION    Elimination of sulfate; appears to act on linkages between
            N-acetyl-D-glucosamine and uronate. Product is an unsaturated
            sugar.
SUBSTRATE   Heparan sulfate
COMMENT     Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated
            glucosamine linkages.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.8
            ExPASy - ENZYME nomenclature database: 4.2.2.8
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.8
            BRENDA, the Enzyme Database: 4.2.2.8
///
ENTRY       EC 4.2.2.9
NAME        Exopolygalacturonate lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Poly(1,4-alpha-D-galacturonide) exo-lyase
REACTION    Eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-
            -enuronosyl)-D-galacturonate from the reducing end of
            de-esterified pectin
SUBSTRATE   De-esterified pectin
PRODUCT     4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate
GENES       YPE: YPO1723(pelW)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.9
            ExPASy - ENZYME nomenclature database: 4.2.2.9
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.9
            BRENDA, the Enzyme Database: 4.2.2.9
///
ENTRY       EC 4.2.2.10
NAME        Pectin lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Poly(methoxygalacturonide)lyase
REACTION    Eliminative cleavage of pectin to give oligosaccharides with
            terminal 4-deoxy-6-methyl-alpha-D-galact-4-enuronosyl groups
SUBSTRATE   Pectin
PRODUCT     Oligosaccharides with terminal 4-deoxy-6-methyl-alpha-D-galact-
            $4-enuronosyl groups
COMMENT     Does not act on de-esterified pectin.
GENES       BSU: BG12643(pelB)
STRUCTURES  PDB: 1QCX  1IDK  1IDJ  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.10
            ExPASy - ENZYME nomenclature database: 4.2.2.10
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.10
            BRENDA, the Enzyme Database: 4.2.2.10
            SCOP (Structural Classification of Proteins): 4.2.2.10
///
ENTRY       EC 4.2.2.11
NAME        Poly(alpha-L-guluronate) lyase
            Alginase II
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Poly(alpha-L-1,4-guluronide) exo-lyase
REACTION    Eliminative cleavage of polysaccharides containing a terminal
            alpha-L-guluronate group, to give oligosaccharides with
            4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their
            non-reducing ends.
SUBSTRATE   Poly(alpha-L-1,4-guluronate)
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.11
            ExPASy - ENZYME nomenclature database: 4.2.2.11
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.11
            BRENDA, the Enzyme Database: 4.2.2.11
///
ENTRY       EC 4.2.2.12
NAME        Xanthan lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     Xanthan lyase
REACTION    Eliminative cleavage of the terminal beta-D-mannosyl-
            -beta-D-1,4-glucuronosyl linkage of the side-chain of the
            polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-
            -4-enuronosyl group at the terminus of the side-chain.
SUBSTRATE   Xanthan
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.12
            ExPASy - ENZYME nomenclature database: 4.2.2.12
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.12
            BRENDA, the Enzyme Database: 4.2.2.12
///
ENTRY       EC 4.2.2.13
NAME        Poly(beta-D-Mannuronate) lyase
            Poly(MANA) alginate lyase
            Alginate lyase I
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
REACTION    Eliminative cleavage of Polysaccharides containing beta-D-
            $Mannuronate residues to give Olugosaccharides with 4-Deoxy-
            $alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.13
            ExPASy - ENZYME nomenclature database: 4.2.2.13
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.13
///
ENTRY       EC 4.2.2.14
NAME        Glucuronan lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Acting on polysaccharides
SYSNAME     (1,4)-beta-D-Glucuronan lyase
REACTION    Eliminative cleavage of (1,4)-beta-D-glucuronans to give
            oligosaccharides with 4-deoxy-beta-Dgluc-4-enuronosyl groups at
            their non-reducing ends. Complete degradation of glucuronans 
            results in the formation of tetrasaccharides.
SUBSTRATE   (1,4)-beta-D-Glucuronan
PRODUCT     Tetrasaccharide
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.2.14
            ExPASy - ENZYME nomenclature database: 4.2.2.14
            WIT (What Is There) Metabolic Reconstruction: 4.2.2.14
///
ENTRY       EC 4.2.99.1
NAME        Transferred to EC 4.2.2.1
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Transferred entry. Now EC 4.2.2.1 - Hyaluronate lyase.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.1
            ExPASy - ENZYME nomenclature database: 4.2.99.1
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.1
///
ENTRY       EC 4.2.99.2
NAME        Threonine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O-Phospho-L-homoserine phospho-lyase (adding water)
REACTION    O-Phospho-L-homoserine + H2O = L-Threonine + Orthophosphate
SUBSTRATE   O-Phospho-L-homoserine
            H2O
PRODUCT     L-Threonine
            Orthophosphate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00750  Vitamin B6 metabolism
GENES       ECO: b0004(thrC)
            ECE: Z0004(thrC)
            ECS: ECs0004
            YPE: YPO0461(thrC)
            HIN: HI0087(thrC)
            PMU: PM0115(thrC)
            XFA: XF2223
            VCH: VC2362
            PAE: PA3735(thrC)
            BUC: BU192(thrC)
            NME: NMB1046
            NMA: NMA1440(thrC)
            HPY: HP0098(thrC)
            HPJ: jhp0090
            CJE: Cj0812(thrC)
            MLO: mll7517 mll9542
            SME: SMc00077(thrC1)
            CCR: CC3399
            BSU: BG10461(thrC)
            BHA: BH3421(thrC)
            SAU: SA1165(thrC)
            SAV: SAV1314(thrC)
            LLA: L0092(thrC)
            SPN: SP2066
            SPR: spr1878(thrC)
            CAC: CAC0999(thrC)
            MTU: Rv1295(thrC)
            MTC: MT1334
            MLE: ML1130(thrC)
            SYN: sll1172(thrC) sll1688(thrC)
            DRA: DRA0360
            AAE: aq_425(thrC2) aq_608(thrC1)
            TMA: TM0546
            MJA: MJ1465(thrC)
            MTH: MTH253
            AFU: AF0551(thrC-1) AF1316(thrC-2)
            HAL: VNG0541G(thrC2) VNG2108G(thrC3) VNG2430G(thrC1)
            TAC: Ta0026 Ta0495
            TVO: TVG0071521 TVG0766521
            PHO: PH0857 PH1406 PH1627
            PAB: PAB0369(thrC-2) PAB1677(thrC-2) PAB1869(thrC-2)
            APE: APE1488 APE2286
            SSO: SSO0493(thrC-1) SSO0878(thrC-2)
            STO: ST0960 ST1240
            SCE: YCR053W(THR4)
            SPO: THRC(thrC)
MOTIF       PS: PS00165  [DESH]-x(4,5)-[STVG]-x-[AS]-[FYI]-K-[DLIFSA]-[RVMF]-
                         [GA]-[LIVMGA]
STRUCTURES  PDB: 1E5X  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.2
            ExPASy - ENZYME nomenclature database: 4.2.99.2
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.2
            BRENDA, the Enzyme Database: 4.2.99.2
///
ENTRY       EC 4.2.99.3
NAME        Transferred to EC 4.2.2.2
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Transferred entry. Now EC 4.2.2.2 - Pectate lyase.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.3
            ExPASy - ENZYME nomenclature database: 4.2.99.3
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.3
///
ENTRY       EC 4.2.99.4
NAME        Transferred to EC 4.2.2.3
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Transferred entry. Now EC 4.2.2.3 - Alginate lyase.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.4
            ExPASy - ENZYME nomenclature database: 4.2.99.4
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.4
///
ENTRY       EC 4.2.99.5
NAME        Deleted entry
            Polyglucuronide lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.5
            ExPASy - ENZYME nomenclature database: 4.2.99.5
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.5
///
ENTRY       EC 4.2.99.6
NAME        Deleted entry
            Chondroitin sulfate lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Deleted entry. Now included with EC 4.2.2.4 and 4.2.2.5.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.6
            ExPASy - ENZYME nomenclature database: 4.2.99.6
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.6
///
ENTRY       EC 4.2.99.7
NAME        Ethanolamine-phosphate phospho-lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     Ethanolamine-phosphate phospho-lyase (deaminating)
REACTION    Ethanolamine phosphate + H2O = Acetaldehyde + NH3 + Orthophosphate
SUBSTRATE   Ethanolamine phosphate
            H2O
            D-1-Aminopropan-2-ol O-phosphate
            L-1-Aminopropan-2-ol O-phosphate
PRODUCT     Acetaldehyde
            NH3
            Orthophosphate
            Acetone
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also acts on D(or L)-1-aminopropan-
            -2-ol O-phosphate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.7
            ExPASy - ENZYME nomenclature database: 4.2.99.7
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.7
            BRENDA, the Enzyme Database: 4.2.99.7
///
ENTRY       EC 4.2.99.8
NAME        Cysteine synthase
            O-Acetylserine (thiol)-lyase
            O-Acetylserine sulfhydrylase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O3-Acetyl-L-serine acetate-lyase (adding hydrogen sulfide)
REACTION    O3-Acetyl-L-serine + Hydrogen sulfide = L-Cysteine + Acetate
SUBSTRATE   O3-Acetyl-L-serine
            Hydrogen sulfide
            Alkyl thiol
            Nitrile
            Pyrazole
            Heterocyclic compound
PRODUCT     L-Cysteine
            Acetate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Some alkyl thiols, cyanide,
            pyrazole and some other heterocyclic compounds can act as
            acceptors. Not identical with EC 4.2.99.14-16.
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b2414(cysK) b2421(cysM)
            ECE: Z3680(cysK) Z3686(cysM)
            ECS: ECs3286 ECs3292
            YPE: YPO2992(cysK) YPO3011(cysM)
            HIN: HI1103(cysK)
            PMU: PM1693(cysK)
            XFA: XF0128 XF0831
            VCH: VC0537 VC0968
            PAE: PA0932(cysM) PA1061 PA2104 PA2709(cysK)
            BUC: BU066(cysK)
            NME: NMB0763
            NMA: NMA0974(cysK)
            HPY: HP0107(cysK)
            HPJ: jhp0099
            CJE: Cj0912c(cysM)
            MLO: mll4616 mlr0353 mlr4651
            SME: SMc00421(cysK1) SMc01174(cysK2)
            CCR: CC1426 CC3625
            BSU: BG10136(cysK) BG12290(yrhA) BG13872(ytkP)
            BHA: BH0088(cysK) BH3271
            SAU: SA0418(cysM) SA0471(cysK)
            SAV: SAV0447 SAV0503(cysK)
            LLA: L0088(cysM) L0089(cysK)
            SPY: SPy1618(cysM)
            SPN: SP2210
            SPR: spr2015(cycK)
            CAC: CAC0931 CAC2235(cysK)
            MTU: Rv0848(cysM3) Rv1336(cysM) Rv2334(cysK) Rv3684
            MTC: MT1377 MT2397
            MLE: ML0839(cysK)
            SYN: sll0712(cysM) slr1842(cysK)
            DRA: DR0789
            AAE: aq_1556(cysM)
            TMA: TM0665
            HAL: VNG0606G(yrhA) VNG1301G(cysK)
            TAC: Ta0535
            TVO: TVG0578372
            PAB: PAB0250
            APE: APE1586
            SSO: SSO0360(cysM)
            SCE: YGR012W YLR303W(MET17)
            SPO: SPAC3A12.17C(spac3a12.17c) SPBC36.04(spbc36.04)
            ATH: At2g43750(F18O19.37) At4g14880(dl3480c)
            CEL: C17G1.7 F59A7.9 K10H10.2 R08E5.2
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
            PS: PS00901  K-x-E-x(3)-[PA]-[STAGC]-x-S-[IVAP]-K-x-R-x-[STAG]-x(2)-
                         [LIVM]
STRUCTURES  PDB: 1OAS  1FCJ  1D6S  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.8
            ExPASy - ENZYME nomenclature database: 4.2.99.8
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.8
            BRENDA, the Enzyme Database: 4.2.99.8
            SCOP (Structural Classification of Proteins): 4.2.99.8
///
ENTRY       EC 4.2.99.9
NAME        O-Succinylhomoserine (thiol)-lyase
            Cystathionine gamma-synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O-Succinyl-L-homoserine succinate-lyase (adding cysteine)
REACTION    O-Succinyl-L-homoserine + L-Cysteine = Cystathionine + Succinate
SUBSTRATE   O-Succinyl-L-homoserine
            L-Cysteine
            Hydrogen sulfide
            Methanethiol
PRODUCT     Cystathionine
            Succinate
            L-Homocysteine
            Methionine
            2-Oxobutanoate
            NH3
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide
            and methanethiol as replacing agents, producing homocysteine and
            methionine respectively. In the absence of thiol, can also
            catalyse beta,gamma-elimination to form 2-oxobutanoate,
            succinate and ammonia.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b3939(metB)
            ECE: Z5494(metB)
            ECS: ECs4868
            YPE: YPO0115(metB)
            HIN: HI0086(metB)
            PMU: PM0995(metB)
            XFA: XF0864
            VCH: VC2683
            NME: NMB0802
            NMA: NMA1012
            HPY: HP0106(metB)
            HPJ: jhp0098
            SME: SMc02595(metB)
            BSU: BG13162(yjcI)
            BHA: BH0542 BH1627(metB)
            SAU: SA0347 SA0419(metB)
            SAV: SAV0348
            LLA: L0102(metB1) L0181(metB2)
            SPN: SP1525
            SPR: spr1377(metB)
            CAC: CAC0390 CAC0930(metB)
            MTU: Rv0391(metZ) Rv1079(metB)
            MTC: MT0402 MT1110
            MLE: ML2394(metB)
            TMA: TM1270
            HAL: VNG1172G(metB)
            TAC: Ta0531
            TVO: TVG1061416
            PAB: PAB0605(metB)
            APE: APE2068
            SSO: SSO2368(metB)
            STO: ST0506
            SCE: YJR130C YML082W(YML082W)
            SPO: SPBC15D4.09C(spbc15d4.09c)
            ATH: At3g01120(T4P13.19)
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
STRUCTURES  PDB: 1I48  1QGN  1I43  1CS1  1I41  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.9
            ExPASy - ENZYME nomenclature database: 4.2.99.9
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.9
            BRENDA, the Enzyme Database: 4.2.99.9
            SCOP (Structural Classification of Proteins): 4.2.99.9
///
ENTRY       EC 4.2.99.10
NAME        O-Acetylhomoserine (thiol)-lyase
            Methionine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O-Acetyl-L-homoserine acetate-lyase (adding methanethiol)
REACTION    O-Acetyl-L-homoserine + Methanethiol = L-Methionine + Acetate
SUBSTRATE   O-Acetyl-L-homoserine
            Methanethiol
            Thiol
            H2S
PRODUCT     L-Methionine
            Acetate
            L-Homocysteine
            Thioether
COMMENT     Also reacts with other thiols and H2S, producing homocysteine or
            thioethers. The name methionine synthase is more commonly applied
            to EC 2.1.1.13. An enzyme from baker's yeast also catalyses the
            reaction of EC 4.2.99.8, but more slowly.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
GENES       PAE: PA5025(metY)
            CJE: Cj1727c(metY)
            BHA: BH2603
            LLA: L75975(cysD)
            SPR: spr1095(metY-truncation) spr1096(metY-truncation)
            CAC: CAC0102 CAC2783(cysD)
            DRA: DR0873 DR2186
            TMA: TM0882
            HAL: VNG2421G(hal)
            SCE: YLR303W(MET17)
            SPO: SPBC428.11(spbc428.11)
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.10
            ExPASy - ENZYME nomenclature database: 4.2.99.10
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.10
            BRENDA, the Enzyme Database: 4.2.99.10
///
ENTRY       EC 4.2.99.11
NAME        Methylglyoxal synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     Glycerone-phosphate phospho-lyase
REACTION    Glycerone phosphate = Methylglyoxal + Orthophosphate
SUBSTRATE   Glycerone phosphate
PRODUCT     Methylglyoxal
            Orthophosphate
COMMENT     Does not act on D-glyceraldehyde 3-phosphate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b0963(mgsA)
            ECE: Z1314(mgsA)
            ECS: ECs1047
            YPE: YPO1441(mgsA)
            HIN: HI1234(mgsa)
            PMU: PM0394(mgsA)
            VCH: VCA0711
            SME: SMc02834(mgsA)
            ATU: AGR_C_311
            BSU: BG11211(mgsA)
            BHA: BH1681(mgsA)
            CAC: CAC1604
            TMA: TM1185
MOTIF       PS: PS01335  S-G-P-[LIVM]-G-G-D-x-Q
STRUCTURES  PDB: 1IK4  1EGH  1B93  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.11
            ExPASy - ENZYME nomenclature database: 4.2.99.11
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.11
            BRENDA, the Enzyme Database: 4.2.99.11
            SCOP (Structural Classification of Proteins): 4.2.99.11
///
ENTRY       EC 4.2.99.12
NAME        Carboxymethyloxysuccinate lyase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     Carboxymethyloxysuccinate glycolate-lyase
REACTION    Carboxymethyloxysuccinate = Fumarate + Glycolate
SUBSTRATE   Carboxymethyloxysuccinate
PRODUCT     Fumarate
            Glycolate
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.12
            ExPASy - ENZYME nomenclature database: 4.2.99.12
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.12
            BRENDA, the Enzyme Database: 4.2.99.12
///
ENTRY       EC 4.2.99.13
NAME        beta-(9-Cytokinin)-alanine synthase
            Lupinic acid synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O-Acetyl-L-serine acetate-lyase (adding N6-substituted adenine)
REACTION    O-Acetyl-L-serine + Zeatin = Lupinate + Acetate
SUBSTRATE   O-Acetyl-L-serine
            Zeatin
PRODUCT     Lupinate
            Acetate
COMMENT     Zeatin (N6-[(E)-4-hydroxy-3-methylbut-2-enylamino] purine) can be
            replaced by a number of N6-substituted purines with cytokinin
            activity, forming the corresponding 3-(purin-9-yl)-L-alanine.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.13
            ExPASy - ENZYME nomenclature database: 4.2.99.13
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.13
            BRENDA, the Enzyme Database: 4.2.99.13
///
ENTRY       EC 4.2.99.14
NAME        beta-Pyrazolylalanine synthase (acetylserine)
            BPA-synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O3-Acetyl-L-serine acetate-lyase (adding pyrazole)
REACTION    O3-Acetyl-L-serine + Pyrazole = 3-(Pyrazol-1-yl)-L-alanine +
            Acetate
SUBSTRATE   O3-Acetyl-L-serine
            Pyrazole
PRODUCT     3-(Pyrazol-1-yl)-L-alanine
            Acetate
COMMENT     The enzyme is highly specific for acetylserine and pyrazole. Not
            identical with EC 4.2.99.15.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.14
            ExPASy - ENZYME nomenclature database: 4.2.99.14
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.14
            BRENDA, the Enzyme Database: 4.2.99.14
///
ENTRY       EC 4.2.99.15
NAME        L-Mimosine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O3-Acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-
            $1-yl)
REACTION    O3-Acetyl-L-serine + 3,4-Dihydroxypyridin =
            3-(3,4-Dihydroxypyridin-1-yl)-L-alanine + Acetate
SUBSTRATE   O3-Acetyl-L-serine
            3,4-Dihydroxypyridin
PRODUCT     3-(3,4-Dihydroxypyridin-1-yl)-L-alanine
            Acetate
COMMENT     Brings about the biosynthesis of L-minosine in Mimosa and
            Leucaena sp. Not identical with EC 4.2.99.14.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.15
            ExPASy - ENZYME nomenclature database: 4.2.99.15
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.15
            BRENDA, the Enzyme Database: 4.2.99.15
///
ENTRY       EC 4.2.99.16
NAME        Uracilylalanine synthase
            Willardiine synthase
            Isowillardiine synthase
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     O3-Acetyl-L-serine acetate-lyase (adding uracil)
REACTION    O3-Acetyl-L-serine + Uracil = 3-(Uracil-1-yl)-L-alanine + Acetate
SUBSTRATE   O3-Acetyl-L-serine
            Uracil
PRODUCT     3-(Uracil-1-yl)-L-alanine
            Acetate
COMMENT     Both L-willardiine and L-isowillardiine are produced in the
            reaction. Not identical with EC 4.2.99.8.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.16
            ExPASy - ENZYME nomenclature database: 4.2.99.16
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.16
            BRENDA, the Enzyme Database: 4.2.99.16
///
ENTRY       EC 4.2.99.17
NAME        Deleted entry
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
COMMENT     Deleted entry. Listed as EC 4.2.99.14.
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.17
            ExPASy - ENZYME nomenclature database: 4.2.99.17
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.17
///
ENTRY       EC 4.2.99.18
NAME        DNA-(apurinic or apyrimidinic site) lyase
            AP lyase
            AP endonuclease Class I
            Endodeoxyribonuclease (apurinic or apyrimidinic)
            Deoxyribonuclease (apurinic or apyrimidinic)
            E. coli endonuclease III
            Phage-T4 UV endonuclease
            Micrococcus luteus UV endonuclease
CLASS       Lyases
            Carbon-oxygen lyases
            Other carbon-oxygen lyases
SYSNAME     DNA-(apurinic or apyrimidinic site) 5'-phosphomonoesterase-lyase
REACTION    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is
            broken by a beta-elimination reaction, leaving a 3'-terminal
            unsaturated sugar and a product with a terminal 5'-phosphate.
SUBSTRATE   DNA
            Apurinic site in DNA
            Apyrimidinic site in DNA
PRODUCT     DNA
COMMENT     'Nicking' of the phosphodiester bond is due to a lyase-type
            reaction, not hydrolysis. This group of enzymes was previously
            listed as endonuclease, under the number EC 3.1.25.2.
GENES       ECO: b1633(nth)
            ECE: Z2644(nth)
            ECS: ECs2342
            YPE: YPO2239(nth)
            HIN: HI1689(nth)
            PMU: PM0381(nth)
            XFA: XF0647
            VCH: VC1011
            PAE: PA3495(nth)
            BUC: BU119(nth)
            NME: NMB0533
            NMA: NMA0711(nth)
            HPY: HP0585(nth) HP0602
            HPJ: jhp0532 jhp0549
            CJE: Cj0595c(nth) Cj1083c
            RPR: RP746(nth)
            RCO: RC1149(nth)
            MLO: mll3176
            SME: SMc02843(nth)
            ATU: AGR_L_820
            CCR: CC2272 CC3731
            BSU: BG10956(nth)
            BHA: BH1698(nth)
            SAU: SA0565 SA1285(nth)
            SAV: SAV0598 SAV1440(nth)
            LLA: L0253(nth)
            SPY: SPy0929(nth)
            SPN: SP1279
            SPR: spr1157(nth)
            CAC: CAC0689(ntH)
            MTU: Rv3674c(nth)
            MTC: MT3775
            MLE: ML2301(nth)
            CTR: CT697
            CMU: TC0069
            CPN: CPn0837
            CPA: CP1032
            CPJ: nth
            BBU: BB0745(nth)
            TPA: TP0775
            SYN: slr1822(nth)
            DRA: DR0289 DR0928 DR2438
            AAE: aq_172(mutY2) aq_282(mutY1) aq_496(mutY3)
            TMA: TM0366 TM0382
            MJA: MJ0613(nth1) MJ1434(nth2)
            MTH: MTH746 MTH764
            AFU: AF1692(nth)
            HAL: VNG0592G(nthA2)
            TAC: Ta0321 Ta0790
            TVO: TVG0824522 TVG1336820
            PHO: PH1498
            PAB: PAB0459(nth)
            APE: APE0150
            SSO: SSO0116(ntH-1) SSO2484(ntH-2)
            STO: ST0964
            SCE: YAL015C(NTG1) YBL019W(APN2) YKL114C(APN1)
            SPO: APN1(apn1) NTH1(nth1)
            ATH: At2g41460(T26J13.5)
            CEL: R10E4.5 T05H10.2(apn-1)
            DME: CG3178(Rrp1) CG7490(RpP0)
            MMU: 88042(Apex)
            HSA: 328(APEX)
DISEASE     MIM: 107748  APEX nuclease (multifunctional DNA repair enzyme)
MOTIF       PS: PS00726  [APF]-D-[LIVMF](2)-x-[LIVM]-Q-E-x-K
            PS: PS00727  D-[ST]-[FY]-R-[KH]-x(7,8)-[FYW]-[ST]-[FYW](2)
            PS: PS00728  N-x-G-x-R-[LIVM]-D-[LIVMFYH]-x-[LV]-x-S
            PS: PS00729  H-[GSAD]-x-Y-[LIF]-[LIMN]-N-[LIVMFCAP]-[AGC]
            PS: PS00730  [GSAR]-[LIVMF]-C-[LIVMFY]-D-T-C-H
            PS: PS00731  [LIVMFW]-H-x-N-[DE]-[SA]-x(4)-[GN]-x(3)-D-x-H
            PS: PS00764  C-x(3)-[KRSN]-P-[KRAGL]-C-x(2)-C-x(5)-C
            PS: PS01155  [GST]-x-[LIVMF]-P-x(5)-[LIVMW]-x(2,3)-[LI]-[PAS]-G-
                         [IV]-[GA]-x(3)-[GAC]-x(3)-[LIVM]-x(2)-[GSALV]-
                         [LIVMFYW]-[GANK]
STRUCTURES  PDB: 1CQH  1CQG  1DE9  1DEW  1HD7  2ABK  1BIX  1DE8  1E9N  
DBLINKS     IUBMB Enzyme Nomenclature: 4.2.99.18
            ExPASy - ENZYME nomenclature database: 4.2.99.18
            WIT (What Is There) Metabolic Reconstruction: 4.2.99.18
            BRENDA, the Enzyme Database: 4.2.99.18
            SCOP (Structural Classification of Proteins): 4.2.99.18
///
ENTRY       EC 4.3.1.1
NAME        Aspartate ammonia-lyase
            Aspartase
            Fumaric aminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-Aspartate ammonia-lyase
REACTION    L-Aspartate = Fumarate + NH3
SUBSTRATE   L-Aspartate
PRODUCT     Fumarate
            NH3
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b4139(aspA)
            ECE: Z5744(aspA)
            ECS: ECs5120
            YPE: YPO0348(aspA)
            HIN: HI0534(aspA)
            PMU: PM1103(aspA)
            VCH: VC2698
            PAE: PA5429
            NME: NMB1029
            NMA: NMA1459(aspA)
            HPY: HP0649(aspA)
            HPJ: jhp0594
            CJE: Cj0087(aspA)
            BSU: BG10301(ansB)
            BHA: BH1426(ansB)
            CAC: CAC0274(ansB) CAC1652(aspA)
            TMA: TM0444
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
STRUCTURES  PDB: 1JSW  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.1
            ExPASy - ENZYME nomenclature database: 4.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.1
            BRENDA, the Enzyme Database: 4.3.1.1
            SCOP (Structural Classification of Proteins): 4.3.1.1
///
ENTRY       EC 4.3.1.2
NAME        Methylaspartate ammonia-lyase
            beta-Methylaspartase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-threo-3-Methylaspartate ammonia-lyase
REACTION    L-threo-3-Methylaspartate = Mesaconate + NH3
SUBSTRATE   L-threo-3-Methylaspartate
PRODUCT     Mesaconate
            NH3
COFACTOR    Cobamide
COMMENT     A cobalamin protein.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.2
            ExPASy - ENZYME nomenclature database: 4.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.2
            BRENDA, the Enzyme Database: 4.3.1.2
///
ENTRY       EC 4.3.1.3
NAME        Histidine ammonia-lyase
            Histidase
            Histidinase
            Histidine alpha-deaminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-Histidine ammonia-lyase
REACTION    L-Histidine = Urocanate + NH3
SUBSTRATE   L-Histidine
PRODUCT     Urocanate
            NH3
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       YPE: YPO4016(hutH)
            VCH: VC1202
            PAE: PA5093 PA5098(hutH)
            MLO: mll0151 mlr8321
            SME: SMa0306 SMb21165(hutH1) SMc00669(hutH2)
            CCR: CC0959
            BSU: BG10667(hutH)
            BHA: BH1982(hutH)
            SAU: SA0008(hutH)
            SAV: SAV0008(hutH)
            SPY: SPy2089(hutH)
            DRA: DRA0147
            HAL: VNG1212G(hutH)
            TAC: Ta0242
            TVO: TVG1425265
            CEL: F47B10.2
            MMU: 96010(Hal)
            HSA: 3034(HAL)
DISEASE     MIM: 235800  Histidine ammonia-lyase (histidase)
MOTIF       PS: PS00488  G-[STG]-[LIVM]-[STG]-[AC]-S-G-[DH]-L-x-P-L-[SA]-x(2)-
                         [SA]
STRUCTURES  PDB: 1B8F  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.3
            ExPASy - ENZYME nomenclature database: 4.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.3
            BRENDA, the Enzyme Database: 4.3.1.3
            SCOP (Structural Classification of Proteins): 4.3.1.3
///
ENTRY       EC 4.3.1.4
NAME        Formiminotetrahydrofolate cyclodeaminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     5-Formiminotetrahydrofolate ammonia-lyase (cyclizing)
REACTION    5-Formiminotetrahydrofolate = 5,10-Methenyltetrahydrofolate + NH3
SUBSTRATE   5-Formiminotetrahydrofolate
PRODUCT     5,10-Methenyltetrahydrofolate
            NH3
COMMENT     In eukaryotes occurs as a bifunctional enzyme also having
            glutamate formiminotransferase (EC 2.1.2.5) activity.
PATHWAY     PATH: MAP00670  One carbon pool by folate
GENES       SPY: SPy2083
            TMA: TM0843
            TAC: Ta1476
            TVO: TVG0092631
            HSA: 10841(FTCD)
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.4
            ExPASy - ENZYME nomenclature database: 4.3.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.4
            BRENDA, the Enzyme Database: 4.3.1.4
///
ENTRY       EC 4.3.1.5
NAME        Phenylalanine ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-Phenylalanine ammonia-lyase
REACTION    L-Phenylalanine = trans-Cinnamate + NH3
SUBSTRATE   L-Phenylalanine
            L-Tyrosine
PRODUCT     trans-Cinnamate
            NH3
            trans-4-Hydroxycinnamate
COMMENT     This enzyme may also act on L-tyrosine.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00910  Nitrogen metabolism
            PATH: MAP00960  Alkaloid biosynthesis II
GENES       ATH: At2g37040(T1J8.22) At3g10340(F14P13.6)
MOTIF       PS: PS00488  G-[STG]-[LIVM]-[STG]-[AC]-S-G-[DH]-L-x-P-L-[SA]-x(2)-
                         [SA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.5
            ExPASy - ENZYME nomenclature database: 4.3.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.5
            BRENDA, the Enzyme Database: 4.3.1.5
///
ENTRY       EC 4.3.1.6
NAME        beta-Alanyl-CoA ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     beta-Alanyl-CoA cmmonia-lyase
REACTION    beta-Alanyl-CoA = Acrylyl-CoA + NH3
SUBSTRATE   beta-Alanyl-CoA
PRODUCT     Acrylyl-CoA
            NH3
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.6
            ExPASy - ENZYME nomenclature database: 4.3.1.6
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.6
            BRENDA, the Enzyme Database: 4.3.1.6
///
ENTRY       EC 4.3.1.7
NAME        Ethanolamine ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     Ethanolamine ammonia-lyase
REACTION    Ethanolamine = Acetaldehyde + NH3
SUBSTRATE   Ethanolamine
PRODUCT     Acetaldehyde
            NH3
COFACTOR    Cobamide
COMMENT     A cobalamin protein.
GENES       ECO: b2440(eutC) b2441(eutB)
            ECE: Z3705(eutC) Z3706(eutB)
            ECS: ECs3311 ECs3312
            PAE: PA4024(eutB)
            CAC: CAC2717 CAC2718
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.7
            ExPASy - ENZYME nomenclature database: 4.3.1.7
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.7
            BRENDA, the Enzyme Database: 4.3.1.7
///
ENTRY       EC 4.3.1.8
NAME        Hydroxymethylbilane synthase
            Porphobilinogen deaminase
            Pre-uroporphyrinogen synthase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     Porphobilinogen ammonia-lyase (polymerizing)
REACTION    4 Porphobilinogen + H2O = Hydroxymethylbilane + 4 NH3
SUBSTRATE   Porphobilinogen
            H2O
PRODUCT     Hydroxymethylbilane
            NH3
COMMENT     In the presence of a second enzyme, EC 4.2.1.75 (uroporphirinogen-
            -III synthase), often called cosynthase, the product is cyclized
            to form uroporphyrinogen-III.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b3805(hemC)
            ECE: Z5319(hemC)
            ECS: ECs4735
            YPE: YPO3849(hemC)
            PMU: PM1812(pbg)
            XFA: XF1627
            VCH: VC0120
            PAE: PA5260(hemC)
            BUC: BU591(hemC)
            NME: NMB0539
            NMA: NMA0718(hemC)
            HPY: HP0237(hemC)
            HPJ: jhp0222
            CJE: Cj0545(hemC)
            RPR: RP466(hemC)
            RCO: RC0706(hemC)
            MLO: mll4223
            SME: SMc03231(hemC)
            CCR: CC0072
            BSU: BG10342(hemC)
            BHA: BH3046(hemC)
            SAU: SA1494(hemC)
            SAV: SAV1655(hemC)
            CAC: CAC0097(hemC)
            MTU: Rv0510(hemC)
            MTC: MT0531
            MLE: ML2421(hemC)
            CTR: CT299
            CMU: TC0572
            CPN: CPn0052
            CPA: CP0723
            CPJ: hemC
            SYN: slr1887(hemC)
            DRA: DR2352
            AAE: aq_263(hemC)
            MJA: MJ0569(hemC)
            MTH: MTH874
            AFU: AF1242(hemC)
            HAL: VNG2330G(hem3)
            TAC: Ta0572
            TVO: TVG0625731
            APE: APE2298
            SSO: SSO0183
            STO: ST0217
            SCE: YDL205C(HEM3)
            SPO: SPAC24B11.13
            DME: CG9165
            MMU: 96112(Hmbs)
            HSA: 3145(HMBS)
DISEASE     MIM: 176000  Hydroxymethylbilane synthase
MOTIF       PS: PS00533  E-[KR]-x-[LIVMFA]-x(3)-[LIVMFA]-x-[GSA]-[GSAN]-C-x-
                         [IVTAC]-P-[LIVMF]-[GSA]
STRUCTURES  PDB: 1AH5  1PDA  1YPN  2YPN  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.8
            ExPASy - ENZYME nomenclature database: 4.3.1.8
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.8
            BRENDA, the Enzyme Database: 4.3.1.8
            SCOP (Structural Classification of Proteins): 4.3.1.8
///
ENTRY       EC 4.3.1.9
NAME        Glucosaminate ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     D-Glucosaminate ammonia-lyase (isomerizing)
REACTION    D-Glucosaminate = 2-Dehydro-3-deoxy-D-gluconate + NH3
SUBSTRATE   D-Glucosaminate
PRODUCT     2-Dehydro-3-deoxy-D-gluconate
            NH3
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.9
            ExPASy - ENZYME nomenclature database: 4.3.1.9
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.9
            BRENDA, the Enzyme Database: 4.3.1.9
///
ENTRY       EC 4.3.1.10
NAME        Serine-sulfate ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-Serine-O-sulfate ammonia-lyase (pyruvate-forming)
REACTION    L-Serine O-sulfate + H2O = Pyruvate + NH3 + Sulfate
SUBSTRATE   L-Serine O-sulfate
            H2O
PRODUCT     Pyruvate
            NH3
            Sulfate
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.10
            ExPASy - ENZYME nomenclature database: 4.3.1.10
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.10
            BRENDA, the Enzyme Database: 4.3.1.10
///
ENTRY       EC 4.3.1.11
NAME        Dihydroxyphenylalanine ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     3,4-Dihydroxy-L-phenylalanine ammonia-lyase
REACTION    3,4-Dihydroxy-L-phenylalanine = trans-Caffeate + NH3
SUBSTRATE   3,4-Dihydroxy-L-phenylalanine
PRODUCT     trans-Caffeate
            NH3
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.11
            ExPASy - ENZYME nomenclature database: 4.3.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.11
            BRENDA, the Enzyme Database: 4.3.1.11
///
ENTRY       EC 4.3.1.12
NAME        Ornithine cyclodeaminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     L-Ornithine ammonia-lyase(cyclizing)
REACTION    L-Ornithine = L-Proline + NH3
SUBSTRATE   L-Ornithine
PRODUCT     L-Proline
            NH3
COFACTOR    NAD+
COMMENT     Requires NAD+.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
GENES       MLO: mll6776
            SME: SMb21494(ocd)
            SAU: SA0113
            SAV: SAV0111
            MTH: MTH1495
            AFU: AF1665(arcB)
            HAL: VNG2224G(ocd1)
            SSO: SSO0378(ocd-like1)
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.12
            ExPASy - ENZYME nomenclature database: 4.3.1.12
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.12
            BRENDA, the Enzyme Database: 4.3.1.12
///
ENTRY       EC 4.3.1.13
NAME        Carbamoyl-serine ammonia-lyase
            O-Carbamoyl-L-serine deaminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
SYSNAME     O-Carbamoyl-L-serine ammonia-lyase (pyruvate-forming)
REACTION    O-Carbamoyl-L-serine + H2O = Pyruvate + 2 NH3 + CO2
SUBSTRATE   O-Carbamoyl-L-serine
            H2O
PRODUCT     Pyruvate
            NH3
            CO2
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.13
            ExPASy - ENZYME nomenclature database: 4.3.1.13
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.13
            BRENDA, the Enzyme Database: 4.3.1.13
///
ENTRY       EC 4.3.1.14
NAME        3-Aminobutyryl-CoA ammonia-lyase
            L-3-Aminobutyryl-CoA deaminase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
REACTION    L-3-Aminobutyryl-CoA = Crotonoyl-CoA + NH3
SUBSTRATE   L-3-Aminobutyryl-CoA
PRODUCT     Crotonoyl-CoA
            NH3
COMMENT     Hydroxylamide can replace Ammonia as a substitute.
            Crotonoyl pantehteine can replace Crotonoyl-CoA but is
            a poorer substrate.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.14
            ExPASy - ENZYME nomenclature database: 4.3.1.14
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.14
///
ENTRY       EC 4.3.1.15
NAME        Diaminopropionate ammonia-lyase
            Diaminopropionatase
            Alpha,beta-diaminopropionate ammonia-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Ammonia-lyases
REACTION    2,3-Diaminopropionate + H2O = Pyruvate + 2 NH3;
            Serine = Pyruvate + NH3
SUBSTRATE   2,3-Diaminopropionate
            H2O
            Serine
PRODUCT     Pyruvate
            NH3
COFACTOR    Pyridoxal phosphate
COMMENT     Active towards both D- and L-diaminopropionate.
            D- and L-Serine are poor substrates.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.1.15
            ExPASy - ENZYME nomenclature database: 4.3.1.15
            WIT (What Is There) Metabolic Reconstruction: 4.3.1.15
///
ENTRY       EC 4.3.2.1
NAME        Argininosuccinate lyase
            Arginosuccinase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amidine-lyases
SYSNAME     N-(L-Argininosuccinate) arginie-lyase
REACTION    N-(L-Arginino)succinate = Fumarate + L-Arginine
SUBSTRATE   N-(L-Arginino)succinate
PRODUCT     Fumarate
            L-Arginine
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b3960(argH)
            ECE: Z5518(argH)
            ECS: ECs4889
            YPE: YPO3924(argH)
            HIN: HI0811(argH)
            PMU: PM1120(argH)
            XFA: XF1003
            VCH: VC2641
            PAE: PA5263(argH)
            BUC: BU051(argH)
            NME: NMB0637
            NMA: NMA0847(argH)
            CJE: Cj0931c(argH)
            MLO: mlr3506
            SME: SMb21094(argH2) SMc00725(argH1)
            CCR: CC2211
            BSU: BG12571(argH)
            BHA: BH3186(argH)
            SAU: SA0821(argH)
            SAV: SAV0947(argH)
            LLA: L0114(argH)
            SPR: spr0103(argH)
            CAC: CAC0974(argH)
            MTU: Rv1659(argH)
            MTC: MT1697
            MLE: ML1413(argH)
            SYN: slr1133(argH)
            DRA: DR0678
            AAE: aq_1372(argH)
            MJA: MJ0791(argH)
            MTH: MTH269
            AFU: AF0883(argH)
            HAL: VNG2436G(argH)
            TAC: Ta0649
            TVO: TVG0980504
            SSO: SSO0639(argH)
            SCE: YHR018C(ARG4)
            SPO: ARG7(arg7) ARGX(argX) SPAC22F3.01
            DME: CG9510
            MMU: 88084(Asl)
            HSA: 435(ASL)
DISEASE     MIM: 207900  Argininosuccinate lyase
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
STRUCTURES  PDB: 1AOS  1AUW  1DCN  1HY0  1HY1  1I0A  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.2.1
            ExPASy - ENZYME nomenclature database: 4.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 4.3.2.1
            BRENDA, the Enzyme Database: 4.3.2.1
            SCOP (Structural Classification of Proteins): 4.3.2.1
///
ENTRY       EC 4.3.2.2
NAME        Adenylsuccinate lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amidine-lyases
SYSNAME     N6-(1,2-Dicarboxyethyl)AMP AMP-lyase
REACTION    N6-(1,2-Dicarboxyethyl)-AMP = Fumarate + AMP
SUBSTRATE   N6-(1,2-Dicarboxyethyl)-AMP
            1-(5'-Phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole
PRODUCT     Fumarate
            AMP
            1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
COMMENT     Also acts on 1-(5'-phosphoribosyl)-4-(N-succinocarboxamide)-
            5-aminoimidazole.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
GENES       ECO: b1131(purB)
            ECE: Z1860(purB)
            ECS: ECs1603
            YPE: YPO1636(purB)
            HIN: HI0639(purB)
            PMU: PM1851(purB)
            XFA: XF1553
            VCH: VC1126
            PAE: PA2629(purB) PA3516 PA3517
            BUC: BU263(purB)
            NME: NMB0284
            NMA: NMA2203(purB)
            HPY: HP1112(purB)
            HPJ: jhp1039
            CJE: Cj0023(purB) Cj1394
            MLO: mll0079
            SME: SMc00508(purB)
            CCR: CC2487
            BSU: BG10702(purB)
            BHA: BH0625(purB)
            SAU: SA1724(purB)
            SAV: SAV1893(purB)
            LLA: L88187(purB)
            SPY: SPy0036(purB)
            SPN: SP0056
            SPR: spr0056(purB)
            CAC: CAC1821(purB)
            MTU: Rv0777(purB)
            MTC: MT0801
            MLE: ML2230(purB)
            SYN: sll0421(purB)
            DRA: DR2178
            AAE: aq_597(purB)
            TMA: TM1095
            MJA: MJ0929(purB)
            MTH: MTH1537
            AFU: AF2242(purB)
            HAL: VNG0415G(purB)
            TAC: Ta0523
            TVO: TVG1053296
            PHO: PH0852
            PAB: PAB0829(purB)
            SSO: SSO0240(purB)
            STO: ST0288
            SCE: YLR359W(ADE13)
            SPO: ADE8(ade8)
            CEL: R06C7.5
            DME: CG3590
            HSA: 158(ADSL)
DISEASE     MIM: 103050  Adenylosuccinate lyase
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
STRUCTURES  PDB: 1C3C  1C3U  1DOF  1F1O  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.2.2
            ExPASy - ENZYME nomenclature database: 4.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 4.3.2.2
            BRENDA, the Enzyme Database: 4.3.2.2
            SCOP (Structural Classification of Proteins): 4.3.2.2
///
ENTRY       EC 4.3.2.3
NAME        Ureidoglycolate lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amidine-lyases
SYSNAME     (-)-Ureidoglycolate urea-lyase
REACTION    (-)-Ureidoglycolate = Glyoxylate + Urea
SUBSTRATE   (-)-Ureidoglycolate
PRODUCT     Glyoxylate
            Urea
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.2.3
            ExPASy - ENZYME nomenclature database: 4.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 4.3.2.3
            BRENDA, the Enzyme Database: 4.3.2.3
///
ENTRY       EC 4.3.2.4
NAME        Purine imidazole-ring cyclase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amidine-lyases
SYSNAME     DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing)
REACTION    DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O
SUBSTRATE   DNA 4,6-diamino-5-formamidopyrimidine
PRODUCT     DNA adenine
            H2O
COMMENT     Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine
            residues. Brings about the reclosure of the imidazole rings of
            purine residues damaged by gamma-rays.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.2.4
            ExPASy - ENZYME nomenclature database: 4.3.2.4
            WIT (What Is There) Metabolic Reconstruction: 4.3.2.4
            BRENDA, the Enzyme Database: 4.3.2.4
///
ENTRY       EC 4.3.2.5
NAME        Peptidylamidoglycolate lyase
            alpha-Hydroxyglycine amidating dealkylase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amidine-lyases
SYSNAME     Peptidylamidoglycolate peptidylamide-lyase
REACTION    Peptidylamidoglycolate = Peptidyl amide + Glyoxylate
SUBSTRATE   Peptidylamidoglycolate
PRODUCT     Peptidyl amide
            Glyoxylate
COMMENT     The enzyme acts on the product of the reaction catalysed by
            EC 1.14.17.3, thus removing a terminal glycine residue and leaving
            a des-glycine peptide amide.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.2.5
            ExPASy - ENZYME nomenclature database: 4.3.2.5
            WIT (What Is There) Metabolic Reconstruction: 4.3.2.5
            BRENDA, the Enzyme Database: 4.3.2.5
///
ENTRY       EC 4.3.3.1
NAME        3-Ketovalidoxylamine C-N-lyase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amine-lyases
SYSNAME     4-Nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase
REACTION    4-Nitrophenyl-3-ketovalidamine = 4-Nitroaniline +
            5-D-(5/6)-5-C-(Hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
SUBSTRATE   4-Nitrophenyl-3-ketovalidamine
PRODUCT     4-Nitroaniline
            5-D-(5/6)-5-C-(Hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one
COFACTOR    Calcium
COMMENT     Requires Ca2+. Eliminates 4-nitroaniline from 4-nitrophenyl-
            -3-ketovalidamine or 4-nitrophenol from 4-nitrophenyl-
            alpha-D-3-dehydroglucoside. Involved in the degradation of the
            fungicide validamycin A by Flavobacterium saccharophilum.
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.3.1
            ExPASy - ENZYME nomenclature database: 4.3.3.1
            WIT (What Is There) Metabolic Reconstruction: 4.3.3.1
            BRENDA, the Enzyme Database: 4.3.3.1
///
ENTRY       EC 4.3.3.2
NAME        Strictosidine synthase
CLASS       Lyases
            Carbon-nitrogen lyases
            Amine-lyases
SYSNAME     3-alpha(S)-Strictosidine tryptamine-lyase
REACTION    3-alpha(S)-Strictosidine = Tryptamine + Secologanin
SUBSTRATE   3-alpha(S)-Strictosidine
PRODUCT     Tryptamine
            Secologanin
COMMENT     Catalyses a reaction between the aldehyde group of secologanin and
            the amino group of tryptamine. Involved in the biosynthesis of the
            monoterpenoid indole alkaloids.
PATHWAY     PATH: MAP00900  Terpenoid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.3.2
            ExPASy - ENZYME nomenclature database: 4.3.3.2
            WIT (What Is There) Metabolic Reconstruction: 4.3.3.2
            BRENDA, the Enzyme Database: 4.3.3.2
///
ENTRY       EC 4.3.99.1
NAME        Cyanate lyase
            Cyanate hydrolase
CLASS       Lyases
            Carbon-nitrogen lyases
            Other Carbon-nitrogen lyases
SYSNAME     Cyanate C-N-lyase
REACTION    Cyanate + Bicarbonate = CO2 + Carbamate
SUBSTRATE   Cyanate
            Bicarbonate
PRODUCT     CO2
            Carbamate
COMMENT     Formerly EC 3.5.5.3.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0340(cynS)
            ECE: Z0436(cynS)
            ECS: ECs0393
            PAE: PA2052(cynS)
            SYN: slr0899(cynS)
            AAE: aq_212(cynS)
            STO: ST1023
STRUCTURES  PDB: 1DW9  1DWK  
DBLINKS     IUBMB Enzyme Nomenclature: 4.3.99.1
            ExPASy - ENZYME nomenclature database: 4.3.99.1
            WIT (What Is There) Metabolic Reconstruction: 4.3.99.1
            UM-BBD (Biocatalysis/Biodegradation Database): 4.3.99.1
            BRENDA, the Enzyme Database: 4.3.99.1
            SCOP (Structural Classification of Proteins): 4.3.99.1
///
ENTRY       EC 4.4.1.1
NAME        Cystathionine gamma-lyase
            Homoserine deaminase
            Homoserine dehydratase
            Cystine desulfhydrase
            Cysteine desulfhydrase
            gamma-Cystathionase
            Cystathionase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Cystathione Lysteine-lyase (deaminating)
REACTION    L-Cystathionine + H2O = L-Cysteine + NH3 + 2-Oxobutanoate
SUBSTRATE   L-Cystathionine
            L-Homoserine
            L-Cystine
            L-Cysteine
            H2O
PRODUCT     L-Cysteine
            2-Oxobutanoate
            Thiocysteine
            Pyruvate
            H2S
            NH3
COFACTOR    Pyridoxal phosphate
EFFECTOR    Cysteine
COMMENT     A multifunctional pyridoxal-phosphate protein. Also catalyses
            elimination reactions of L-homoserine to form H2O, NH3, and
            2-oxobutanoate and of L-cystine, producing thiocysteine, pyruvate
            and NH3 and of L-cysteine producing pyruvate, NH3, and H2S.
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       PAE: PA0400
            MLO: mll4503
            BSU: BG12291(yrhB)
            BHA: BH1736
            HAL: VNG0796G(cgs)
            TAC: Ta0080
            TVO: TVG0183353
            PHO: PH1093
            APE: APE1226
            SCE: YAL012W(CYS3)
            CEL: C12C8.2 F22B8.6 ZK1127.10
            DME: CG5345(Eip55E)
            HSA: 1491(CTH)
DISEASE     MIM: 219500  Cystathionase
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.1
            ExPASy - ENZYME nomenclature database: 4.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.1
            BRENDA, the Enzyme Database: 4.4.1.1
///
ENTRY       EC 4.4.1.2
NAME        Homocysteine desulfhydrase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Homocysteine hydrogen-sulfide-lyase (deaminating)
REACTION    L-Homocysteine + H2O = Sulfide + NH3 + 2-Oxobutanoate
SUBSTRATE   L-Homocysteine
            H2O
PRODUCT     Sulfide
            NH3
            2-Oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00910  Nitrogen metabolism
            PATH: MAP00920  Sulfur metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.2
            ExPASy - ENZYME nomenclature database: 4.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.2
            BRENDA, the Enzyme Database: 4.4.1.2
///
ENTRY       EC 4.4.1.3
NAME        Dimethylpropiothetin dethiomethylase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     S,S-Dimethyl-beta-propiothetin dimethyl-sulfide-lyase
REACTION    S,S-Dimethyl-beta-propiothetin = Dimethyl sulfide + Acrylate
SUBSTRATE   S,S-Dimethyl-beta-propiothetin
PRODUCT     Dimethyl sulfide
            Acrylate
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.3
            ExPASy - ENZYME nomenclature database: 4.4.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.3
            BRENDA, the Enzyme Database: 4.4.1.3
///
ENTRY       EC 4.4.1.4
NAME        Alliin lyase
            Alliinase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Alliin alkyl-sulfenate-lyase
REACTION    an S-Alkyl-L-cysteine S-oxide = an Alkyl sulfenate +
            2-Aminoacrylate
SUBSTRATE   S-Alkyl-L-cysteine S-oxide
PRODUCT     Alkyl sulfenate
            2-Aminoacrylate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.4
            ExPASy - ENZYME nomenclature database: 4.4.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.4
            BRENDA, the Enzyme Database: 4.4.1.4
///
ENTRY       EC 4.4.1.5
NAME        Lactoylglutathione lyase
            Methylglyoxalase
            Aldoketomutase
            Ketone-aldehyde mutase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
REACTION    (R)-S-Lactoylglutathione = Glutathione + Methylglyoxal
SUBSTRATE   (R)-S-Lactoylglutathione
            3-Phosphoglycerol-glutathione
PRODUCT     Glutathione
            Methylglyoxal
INHIBITOR   S-(N-Hydroxy-N-methylcarbamoyl)glutathione
COMMENT     Also acts on 3-phosphoglycerol-glutathione.
            Inhibited by S-(N-hydroxy-N-methylcarbamoyl)glutathione (
            J.Biol.Chem.  267(35), 24933-24936 (1992) ).
PATHWAY     PATH: MAP00620  Pyruvate metabolism
GENES       ECO: b1651(gloA)
            ECE: Z2669(gloA)
            ECS: ECs2360
            YPE: YPO2381(gloA)
            HIN: HI0323(gloa)
            PMU: PM0987(gloA)
            XFA: XF1399
            VCH: VC1010
            PAE: PA0710(gloA2) PA3524(gloA1) PA5111(gloA3)
            NME: NMB0340
            NMA: NMA2147(gloA)
            MLO: mll0167
            SME: SMc00290(gloA)
            CCR: CC1315
            SPY: SPy0511(gloA)
            SPN: SP0962
            SPR: spr0864(lguL)
            SYN: slr0381(gloA)
            MTH: MTH758
            PAB: PAB2438
            SSO: SSO2426
            STO: ST0554
            SCE: YML004C(GLO1)
            SPO: SPBC21D10.03C
            DME: CG1707
            MMU: 95742(Glo1)
            HSA: 2739(GLO1)
DISEASE     MIM: 138750  Glyoxalase I
MOTIF       PS: PS00934  [HQ]-[IVT]-x-[LIVFY]-x-[IV]-x(5)-[STA]-x(2)-F-[YM]-
                         x(2,3)-[LMF]-G-[LMF]
            PS: PS00935  G-[NTKQ]-x(0,5)-[GA]-[LVFY]-[GH]-H-[IVF]-[CGA]-x-
                         [STAGLE]-x(2)-[DNC]
STRUCTURES  PDB: 1QIP  1QIN  1FRO  1FA8  1BH5  1F9Z  1FA5  1FA6  1FA7  
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.5
            ExPASy - ENZYME nomenclature database: 4.4.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.5
            BRENDA, the Enzyme Database: 4.4.1.5
            SCOP (Structural Classification of Proteins): 4.4.1.5
///
ENTRY       EC 4.4.1.6
NAME        S-Alkylcysteine lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     S-Alkyl-L-cysteine alkylthiol-lyase (deaminating)
REACTION    an S-Alkyl-L-cysteine + H2O = an Alkyl thiol + NH3 + Pyruvate
SUBSTRATE   S-Alkyl-L-cysteine
            H2O
PRODUCT     Alkyl thiol
            NH3
            Pyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Decomposes S-alkyl-L-cysteines by
            alpha,beta-elimination. Possibly identical, in yeast, with
            EC 4.4.1.8.
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.6
            ExPASy - ENZYME nomenclature database: 4.4.1.6
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.6
            BRENDA, the Enzyme Database: 4.4.1.6
///
ENTRY       EC 4.4.1.7
NAME        Deleted entry
            S-(Hydroxyalkyl)glutathione lyase
CLASS       Lyases
            Carbon-sulfur lyases
COMMENT     Deleted entry. Now included with EC 2.5.1.18.
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.7
            ExPASy - ENZYME nomenclature database: 4.4.1.7
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.7
///
ENTRY       EC 4.4.1.8
NAME        Cystathionine beta-lyase
            beta-Cystathionase
            Cystine lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Cystathione L-homocysteine-lyase (deaminating)
REACTION    Cystathionine + H2O = L-Homocysteine + NH3 + Pyruvate
SUBSTRATE   Cystathionine
            L-Cystine
            H2O
PRODUCT     L-Homocysteine
            NH3
            Pyruvate
            Cysteine persulfide
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The enzyme from some sources also
            acts on L-cystine, forming pyruvate, ammonia and cysteine
            persulfide, and a number of related compounds. Possibly identical,
            in yeast, with EC 4.4.1.6
            (EC 4.4.1.6 S-Alkylcysteine lyase)
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
            PATH: MAP00920  Sulfur metabolism
GENES       ECO: b3008(metC)
            ECE: Z4361(metC)
            ECS: ECs3892
            YPE: YPO0278(metC)
            HIN: HI0122(metC)
            PMU: PM0738(metC_1) PM0794(metC_2)
            VCH: VC1671
            CJE: Cj1392(metC') Cj1393(metC')
            MLO: mll8145 mll9139
            SME: SMc02117(metC)
            CCR: CC1424
            BSU: BG13163(yjcJ)
            BHA: BH1628(metC)
            SAU: SA0346
            SAV: SAV0347
            SPY: SPy0172(metB)
            CAC: CAC0391
            MTU: Rv3340(metC)
            MTC: MT3443
            SCE: YFR055W
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
STRUCTURES  PDB: 1IBJ  1CL2  1CL1  
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.8
            ExPASy - ENZYME nomenclature database: 4.4.1.8
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.8
            BRENDA, the Enzyme Database: 4.4.1.8
            SCOP (Structural Classification of Proteins): 4.4.1.8
///
ENTRY       EC 4.4.1.9
NAME        L-3-Cyanoalanine synthase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Cysteine hydrogen-sulfide-lyase (adding HCN)
REACTION    L-Cysteine + HCN = Sulfide + 3-Cyano-L-alanine
SUBSTRATE   L-Cysteine
            HCN
PRODUCT     Sulfide
            3-Cyano-L-alanine
PATHWAY     PATH: MAP00460  Cyanoamino acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.9
            ExPASy - ENZYME nomenclature database: 4.4.1.9
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.9
            BRENDA, the Enzyme Database: 4.4.1.9
///
ENTRY       EC 4.4.1.10
NAME        Cysteine lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Cysteine hydrogen-sulfide-lyase (adding sulfite)
REACTION    L-Cysteine + Sulfite = L-Cysteate + Sulfide
SUBSTRATE   L-Cysteine
            Sulfite
PRODUCT     L-Cysteate
            Sulfide
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Can use a second molecule of
            cysteine (producing lanthionine) or other alkyl thiols as
            replacing agents.
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.10
            ExPASy - ENZYME nomenclature database: 4.4.1.10
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.10
            BRENDA, the Enzyme Database: 4.4.1.10
///
ENTRY       EC 4.4.1.11
NAME        Methionine gamma-lyase
            L-Methioninase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Methionine methanethiol-lyase (deaminating)
REACTION    L-Methionine = Methanethiol + NH3 + 2-Oxobutanoate
SUBSTRATE   L-Methionine
PRODUCT     Methanethiol
            NH3
            2-Oxobutanoate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
GENES       SME: SMc01666(mdeA)
            CCR: CC3168
            BHA: BH0799
MOTIF       PS: PS00868  [DQ]-[LIVMF]-x(3)-[STAGC]-[STAGCI]-T-K-[FYWQ]-[LIVMF]-
                         x-G-[HQ]-[SGNH]
STRUCTURES  PDB: 1E5F  1E5E  
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.11
            ExPASy - ENZYME nomenclature database: 4.4.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.11
            UM-BBD (Biocatalysis/Biodegradation Database): 4.4.1.11
            BRENDA, the Enzyme Database: 4.4.1.11
///
ENTRY       EC 4.4.1.12
NAME        Sulfoacetaldehyde lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Sulfoacetaldehyde sulfo-lyase
REACTION    Sulfoacetaldehyde + H2O = Sulfite + Acetate
SUBSTRATE   Sulfoacetaldehyde
            H2O
PRODUCT     Sulfite
            Acetate
COFACTOR    Thiamine diphosphate
COMMENT     Requires thiamine diphosphate.
PATHWAY     PATH: MAP00430  Taurine and hypotaurine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.12
            ExPASy - ENZYME nomenclature database: 4.4.1.12
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.12
            BRENDA, the Enzyme Database: 4.4.1.12
///
ENTRY       EC 4.4.1.13
NAME        Cysteine-S-conjugate beta-lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Cysteine-S-conjugate thiol-lyase (deaminating)
REACTION    RS-CH2-CH(NH3+)COO- = RSH + NH3 + Pyruvate
SUBSTRATE   RS-CH2-CH(NH3+)COO-
PRODUCT     RSH
            NH3
            Pyruvate
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. In the reaction, RH may represent
            aromatic compounds such as 4-bromobenzene and 2,4-dinitrobenzene.
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.13
            ExPASy - ENZYME nomenclature database: 4.4.1.13
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.13
            BRENDA, the Enzyme Database: 4.4.1.13
///
ENTRY       EC 4.4.1.14
NAME        1-Aminocyclopropane-1-carboxylate synthase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     S-Adenosyl-L-methionine methylthioadenosine-lyase
REACTION    S-Adenosyl-L-methionine = 1-Aminocyclopropane-1-carboxylate +
            Methylthioadenosine
SUBSTRATE   S-Adenosyl-L-methionine
PRODUCT     1-Aminocyclopropane-1-carboxylate
            Methylthioadenosine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. The enzyme catalyses an
            alpha,gamma-elimination.
PATHWAY     PATH: MAP00640  Propanoate metabolism
GENES       ATH: At1g01480(F22L4.4) At2g22810(T20K9.2) At4g11280(F8L21.70)
                 At5g65800(MPA24.15)
MOTIF       PS: PS00105  [GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-
                         [GNAR]-x-R-[LIVMA]-[GA]
STRUCTURES  PDB: 1IAY  1B8G  1IAX  
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.14
            ExPASy - ENZYME nomenclature database: 4.4.1.14
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.14
            BRENDA, the Enzyme Database: 4.4.1.14
            SCOP (Structural Classification of Proteins): 4.4.1.14
///
ENTRY       EC 4.4.1.15
NAME        D-Cysteine desulfhydrase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     D-Cysteine sulfide-lyase (deaminating)
REACTION    D-Cysteine + H2O = Sulfide + NH3 + Pyruvate
SUBSTRATE   D-Cysteine
            H2O
PRODUCT     Sulfide
            NH3
            Pyruvate
PATHWAY     PATH: MAP00272  Cysteine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.15
            ExPASy - ENZYME nomenclature database: 4.4.1.15
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.15
            BRENDA, the Enzyme Database: 4.4.1.15
///
ENTRY       EC 4.4.1.16
NAME        Selenocysteine lyase
            Selenocysteine reductase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     L-Selenocysteine reductase
REACTION    L-Selenocysteine + Reduced acceptor = Selenide + L-Alanine +
            Acceptor
SUBSTRATE   L-Selenocysteine
            Reduced acceptor
            Dithiothreitol
            2-Mercaptoethanol
PRODUCT     Selenide
            L-Alanine
            Acceptor
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Dithiothreitol or 2-mercaptoethanol
            can act as reducing agent in the reaction. The enzyme does not act
            on cysteine, serine or chloroalanine.
PATHWAY     PATH: MAP00450  Selenoamino acid metabolism
GENES       ECO: b1680
            ECE: Z2708
            ECS: ECs2387
STRUCTURES  PDB: 1JF9  
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.16
            ExPASy - ENZYME nomenclature database: 4.4.1.16
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.16
            BRENDA, the Enzyme Database: 4.4.1.16
///
ENTRY       EC 4.4.1.17
NAME        Holocytochrome-c synthase
            Cytochrome c heme-lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Holocytochrome-c apocytochrome-c-lyase
REACTION    Holocytochrome c = Apocytochrome c + Heme
SUBSTRATE   Holocytochrome c
PRODUCT     Apocytochrome c
            Heme
COMMENT     In the reverse direction, the enzyme catalyses the attachment of
            heme to two cysteine residues in the protein, forming thioether
            links.
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       SCE: YAL039C(CYC3)
            SPO: SPAC24C9.02C(spac24c9.02c) SPBC26H8.12(spbc26h8.12)
            CEL: T06D8.6
            DME: CG6022
            HSA: 3052(HCCS)
DISEASE     MIM: 300056  Holocytochrome c synthase (cytochrome c heme-lyase)
MOTIF       PS: PS00821  H-N-x(2)-N-E-x(2)-W-[NQKR]-x(4)-W-E
            PS: PS00822  P-F-D-R-H-D-W
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.17
            ExPASy - ENZYME nomenclature database: 4.4.1.17
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.17
            BRENDA, the Enzyme Database: 4.4.1.17
///
ENTRY       EC 4.4.1.18
NAME        Prenylcysteine lyase
CLASS       Lyases
            Carbon-sulfur lyases
SYSNAME     Prenyl-L-cysteine:L-cysteine-lyase
REACTION    a Prenyl-L-cysteine + H2O = a Prenol + L-Cysteine
SUBSTRATE   Prenyl-L-cysteine
            H2O
PRODUCT     Prenol
            L-Cysteine
COMMENT     Cleaves the thioether bond of prenyl-L-cysteines, such as
            farnesylcysteine and geranylgeranylcysteine. N-Acetyl-
            prenylcysteine and prenylcysteinyl peptides are not substrates. May
            represent the final step in the degradation of prenylated proteins
            in mammalian tissues. In contrast to the monooxygenases (EC
            1.14.13.-), neither O2 nor NADPH are required.
GENES       HSA: 51449(PCL1)
DBLINKS     IUBMB Enzyme Nomenclature: 4.4.1.18
            ExPASy - ENZYME nomenclature database: 4.4.1.18
            WIT (What Is There) Metabolic Reconstruction: 4.4.1.18
///
ENTRY       EC 4.5.1.1
NAME        DDT-dehydrochlorinase
CLASS       Lyases
            Carbon-halide lyases
SYSNAME     1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane
            $ chloride-lyase
REACTION    1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane =
            1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene + HCl
SUBSTRATE   1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane
PRODUCT     1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene
            HCl
PATHWAY     PATH: MAP00351  1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
DBLINKS     IUBMB Enzyme Nomenclature: 4.5.1.1
            ExPASy - ENZYME nomenclature database: 4.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.5.1.1
            UM-BBD (Biocatalysis/Biodegradation Database): 4.5.1.1
            BRENDA, the Enzyme Database: 4.5.1.1
///
ENTRY       EC 4.5.1.2
NAME        3-Chloro-D-alanine dehydrochlorinase
CLASS       Lyases
            Carbon-halide lyases
SYSNAME     3-Chloro-D-alanine chloride-lyase (deaminating)
REACTION    3-Chloro-D-alanine + H2O = Pyruvate + Chloride + NH3
SUBSTRATE   3-Chloro-D-alanine
            H2O
            H2S
PRODUCT     Pyruvate
            Chloride
            NH3
            D-Cysteine
            HCl
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein. Also catalyses beta-replacement
            reactions, e.g. converts 3-chloro-D-alanine and H2S into
            D-Cysteine and HCl.
DBLINKS     IUBMB Enzyme Nomenclature: 4.5.1.2
            ExPASy - ENZYME nomenclature database: 4.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.5.1.2
            BRENDA, the Enzyme Database: 4.5.1.2
///
ENTRY       EC 4.5.1.3
NAME        Dichloromethane dehalogenase
CLASS       Lyases
            Carbon-halide lyases
SYSNAME     Dichloromethane chloride-lyase (chloride-hydrolysing)
REACTION    Dichloromethane + H2O = Formaldehyde + 2 Chloride
SUBSTRATE   Dichloromethane
            H2O
PRODUCT     Formaldehyde
            Chloride
COFACTOR    Glutathione
COMMENT     Requires glutathione.
DBLINKS     IUBMB Enzyme Nomenclature: 4.5.1.3
            ExPASy - ENZYME nomenclature database: 4.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.5.1.3
            UM-BBD (Biocatalysis/Biodegradation Database): 4.5.1.3
            BRENDA, the Enzyme Database: 4.5.1.3
///
ENTRY       EC 4.5.1.4
NAME        L-2-Amino-4-chloropent-4-enoate dehydrochlorinase
CLASS       Lyases
            Carbon-halide lyases
SYSNAME     L-2-Amino-4-chloropent-4-enoate chloride-lyase (deaminating)
REACTION    L-2-Amino-4-chloropent-4-enoate + H2O = 2-Oxopent-4-enoate +
            Chloride + NH3
SUBSTRATE   L-2-Amino-4-chloropent-4-enoate
            H2O
PRODUCT     2-Oxopent-4-enoate
            Chloride
            NH3
DBLINKS     IUBMB Enzyme Nomenclature: 4.5.1.4
            ExPASy - ENZYME nomenclature database: 4.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.5.1.4
            BRENDA, the Enzyme Database: 4.5.1.4
///
ENTRY       EC 4.5.1.5
NAME        S-Carboxymethylcysteine synthase
CLASS       Lyases
            Carbon-halide lyases
SYSNAME     3-Chloro-L-alanine chloride-lyase (adding thioglycolate)
REACTION    3-Chloro-L-alanine + Thioglycolate = S-Carboxymethyl-L-cysteine +
            Chloride
SUBSTRATE   3-Chloro-L-alanine
            Thioglycolate
PRODUCT     S-Carboxymethyl-L-cysteine
            Chloride
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 4.5.1.5
            ExPASy - ENZYME nomenclature database: 4.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.5.1.5
            BRENDA, the Enzyme Database: 4.5.1.5
///
ENTRY       EC 4.6.1.1
NAME        Adenylate cyclase
            Adenylylcyclase
            Adenyl cyclase
            3',5'-Cyclic AMP synthetase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     ATP pyrophosphate-lyase (cyclizing)
REACTION    ATP = 3',5'-Cyclic AMP + Pyrophosphate
SUBSTRATE   ATP
            dATP
PRODUCT     3',5'-Cyclic AMP
            3',5'-Cyclic dAMP
            Pyrophosphate
COFACTOR    Pyruvate
EFFECTOR    NAD+
COMMENT     Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate.
            Activated by NAD+ in the presence of EC 2.4.2.31.
            (EC 2.4.2.31 NAD(P)+-arginine ADP-ribosyltransferase)
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b3806(cyaA)
            ECE: Z5322(cyaA)
            ECS: ECs4736
            YPE: YPO1178(cyaB) YPO3848(cyaA)
            HIN: HI0604(cyaA)
            PMU: PM1811(cyaA)
            VCH: VC0122
            PAE: PA5272(cyaA)
            SME: SMa1046 SMa1103 SMa1583(cyaF5) SMb20300(cyaF7)
                 SMb20539(cyaF6) SMb20707(cyaG2) SMb20776(cyaK) SMc00339(cyaA)
                 SMc00621(cyaB) SMc01818(cyaC) SMc02176(cyaD1) SMc02285(cyaE)
                 SMc03099(cyaF1) SMc03937(cyaG1) SMc03985(cyaF2) SMc04172(cyaH)
                 SMc04307(cyaD2) SMc04343(cyaJ)
            MTU: Rv1318c Rv1319c Rv1320c
            MTC: MT1359 MT1360 MT1361 MT1362
            TPA: TP0485
            SYN: sll1161(cya3) slr1991(cya1)
            SCE: YJL005W(CYR1)
            SPO: CYR1(cyr1)
            CEL: F17C8.1
            DME: CG10564(Ac78C) CG12243 CG1506(Ac3) CG17174 CG17176 CG17178
                 CG5712 CG5983 CG7978(Ac76E) CG8970 CG9210(Ac13E) CG9533(rut)
            MMU: 87917(Adcy6)
            HSA: 107(ADCY1) 108(ADCY2) 109(ADCY3) 110(ADCY4) 111(ADCY5)
                 112(ADCY6) 113(ADCY7) 114(ADCY8) 115(ADCY9)
DISEASE     MIM: 103070  Adenylyl cyclase-8, brain
            MIM: 103071  Adenylyl cyclase-2, brain
            MIM: 103072  Adenylate cyclase-1, brain
            MIM: 600385  Adenylate cyclase-7
            MIM: 603302  Adenylate cyclase-9
MOTIF       PS: PS00330  D-x-[LI]-x(4)-G-x-D-x-[LI]-x-G-G-x(3)-D
            PS: PS00452  G-V-[LIVM]-x(0,1)-G-x(5)-[FY]-x-[LIVM]-[FYW]-[GS]-
                         [DNTHKW]-[DNT]-[IV]-[DNTA]-x(5)-[DE]
            PS: PS01092  E-Y-F-G-[SA](2)-L-W-x-L-Y-K
            PS: PS01093  Y-R-N-x-W-[NS]-E-[LIVM]-R-T-L-H-F-x-G
STRUCTURES  PDB: 1AB8  1AWK  1AWM  1AZS  1CJK  1CJT  1CJU  1CJV  1CS4  1CUL  
                 1FX2  1FX4  
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.1
            ExPASy - ENZYME nomenclature database: 4.6.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.1
            BRENDA, the Enzyme Database: 4.6.1.1
            SCOP (Structural Classification of Proteins): 4.6.1.1
///
ENTRY       EC 4.6.1.2
NAME        Guanylate cyclase
            Guanylyl cyclase
            Guanyl cyclase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     GTP pyrophosphate-lyase (cyclizing)
REACTION    GTP = 3',5'-Cyclic GMP + Pyrophosphate
SUBSTRATE   GTP
            ITP
            dGTP
PRODUCT     3',5'-Cyclic GMP
            Pyrophosphate
            3',5'-Cyclic IMP
            3',5'-Cyclic dGMP
COMMENT     Also acts on ITP and dGTP.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       SYN: sll0646(cya2)
            CEL: AH6.1(gcy-1) B0024.6(gcy-6) C06B3.8(gcy-32) C17F4.6
                 C30G4.3(gcy-11) C49H3.1 C49H3.2(gcy-8) F21H7.9 F22E5.3
                 F23H12.6(gcy-13) F52E1.4(gcy-7) R134.1(gcy-3) R134.2(gcy-2)
                 T03D8.5 T26C12.4 W03F11.2 ZC412.2(gcy-14) ZK455.2(gcy-9)
                 ZK896.8 ZK970.5(gcy-4) ZK970.6(gcy-5)
            DME: CG10738 CG1470(Gycbeta100B) CG1912(Gycalpha99B)
                 CG6275(Gyc32E) CG8742(Gyc76C) CG9763(pyd)
            MMU: 105123(Gucy2e) 97371(Npr1)
            HSA: 2974(GUCY1B2) 2977(GUCY1A2) 2982(GUCY1A3) 2983(GUCY1B3)
                 2984(GUCY2C) 2986(GUCY2F) 3000(GUCY2D) 4881(NPR1) 4882(NPR2)
DISEASE     MIM: 108960  Natriuretic peptide receptor A/guanylate cyclase A
            MIM: 108961  Natriuretic peptide receptor B/guanylate cyclase B
            MIM: 139396  Guanylate cyclase 1, soluble, alpha 3
            MIM: 139397  Guanylate cyclase 1, soluble, beta 3
            MIM: 300041  Guanylate cyclase 2F
            MIM: 600179  Guanylate cyclase 2D, membrane, retina-specific
            MIM: 601244  Guanylate cyclase 1, soluble, alpha 2
            MIM: 601330  Guanylate cyclase 2C (heat stable enterotoxin
                         receptor)
MOTIF       PS: PS00452  G-V-[LIVM]-x(0,1)-G-x(5)-[FY]-x-[LIVM]-[FYW]-[GS]-
                         [DNTHKW]-[DNT]-[IV]-[DNTA]-x(5)-[DE]
            PS: PS00458  G-P-x-C-x-Y-x-A-A-x-V-x-R-x(3)-H-W
            PS: PS50011  Protein kinase domain profile
STRUCTURES  PDB: 1AWL  1AWN  1DP4  1JBA  
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.2
            ExPASy - ENZYME nomenclature database: 4.6.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.2
            BRENDA, the Enzyme Database: 4.6.1.2
            SCOP (Structural Classification of Proteins): 4.6.1.2
///
ENTRY       EC 4.6.1.3
NAME        3-Dehydroquinate synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     3-Deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase
            (cyclyzing)
REACTION    2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate = 
            3-Dehydroquinate + Orthophosphate
SUBSTRATE   2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate
PRODUCT     3-Dehydroquinate
            Orthophosphate
COFACTOR    Cobalt
COMMENT     Requires Co2+. The hydrogen atoms on C-7 of the substrate are
            retained on C-2 of the product.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b3389(aroB)
            ECE: Z4742(aroB)
            ECS: ECs4231
            YPE: YPO0152(aroB)
            HIN: HI0208(aroB)
            PMU: PM1223(aroB)
            XFA: XF1334
            VCH: VC2628
            PAE: PA5038(aroB)
            BUC: BU538(aroB)
            NME: NMB1814
            NMA: NMA0647(aroB)
            HPY: HP0283(aroB)
            HPJ: jhp0268
            CJE: Cj1008c(aroB)
            MLO: mll3571
            SME: SMc00696(aroB)
            CCR: CC3009
            BSU: BG10285(aroB)
            BHA: BH1657(aroB)
            SAU: SA1298(aroB)
            SAV: SAV1454(aroB)
            LLA: L0060(aroB)
            SPY: SPy1577(aroB)
            SPN: SP1375
            SPR: spr1233(aroB)
            CAC: CAC0894(aroB)
            MTU: Rv2538c(aroB)
            MTC: MT2613
            MLE: ML0518(aroB)
            CTR: CT369
            CMU: TC0648
            CPN: CPn1036
            CPA: CP0816
            CPJ: aroB
            SYN: slr2130(aroB)
            DRA: DR0777
            TMA: TM0348
            TAC: Ta0285
            TVO: TVG1384310
            PAB: PAB0298(aroB)
            APE: APE0579
            SSO: SSO0305(aroB)
            SCE: YDR127W(ARO1)
            SPO: ARO1(aro1)
            ATH: At5g66120(K2A18.20)
MOTIF       PS: PS00104  [LIVF]-x(2)-[GANQK]-[NLG]-[SA]-[GA]-[TAI]-[STAGV]-x-R-
                         x-[LIVMFYAT]-x-[GSTAP]
            PS: PS00885  [KR]-x-[KH]-E-[CST]-[DNE]-R-[LIVM]-x-[GSTAV]-[LIVMCT]-
                         x(3)-[LIVMF]-x(2)-[LIVMFCGAN]-G
            PS: PS01028  D-[LIVM]-[DE]-[LIVMN]-x(18,20)-[LIVM](2)-x-[SC]-[NHY]-
                         H-[DN]
            PS: PS01128  [KR]-x(2)-E-x(3)-[LIVMF]-x(8,12)-[LIVMF](2)-[SA]-x-
                         G(3)-x-[LIVMFG]
STRUCTURES  PDB: 1DQS  
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.3
            ExPASy - ENZYME nomenclature database: 4.6.1.3
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.3
            BRENDA, the Enzyme Database: 4.6.1.3
            SCOP (Structural Classification of Proteins): 4.6.1.3
///
ENTRY       EC 4.6.1.4
NAME        Chorismate synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     5-O-(1-Carboxyvinyl)-3-phosphoshikimate phosphate-lyase
REACTION    5-O-(1-Carboxyvinyl)-3-phosphoshikimate = Chorismate +
            Orthophosphate
SUBSTRATE   5-O-(1-Carboxyvinyl)-3-phosphoshikimate
PRODUCT     Chorismate
            Orthophosphate
COMMENT     Shikimate is numbered so that the double-bond is between C-1 and
            C-2, but some earlier papers numbered the ring in the reverse
            direction.
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2329(aroC)
            ECE: Z3592(aroC)
            ECS: ECs3213
            YPE: YPO2751(aroC)
            HIN: HI0196(aroC)
            PMU: PM0359(aroC)
            XFA: XF1369
            VCH: VC2116
            PAE: PA1681(aroC)
            BUC: BU097(aroC)
            NME: NMB1680
            NMA: NMA1939(aroC)
            HPY: HP0663(aroC)
            HPJ: jhp0608
            CJE: Cj1634c(aroC)
            MLO: mlr7461
            SME: SMc00007(aroC)
            CCR: CC3154
            BSU: BG10284(aroF)
            BHA: BH1656(aroF)
            SAU: SA1299(aroC)
            SAV: SAV1455(aroC)
            LLA: L0059(aroC)
            SPN: SP1374
            SPR: spr1232(aroC)
            CAC: CAC0896(aroC)
            MTU: Rv2540c(aroF)
            MTC: MT2615
            MLE: ML0516(aroF)
            CTR: CT368
            CMU: TC0647
            CPN: CPn1037
            CPA: CP0815
            CPJ: aroC
            SYN: sll1747(aroC)
            DRA: DR0775
            AAE: aq_081(aroC)
            TMA: TM0347
            MJA: MJ1175(aroC)
            MTH: MTH748
            AFU: AF0670(aroC)
            HAL: VNG1230G(aroC)
            TAC: Ta0824
            TVO: TVG0743399
            PAB: PAB0307(aroC)
            APE: APE0564
            SSO: SSO0307(aroC)
            SCE: YGL148W(ARO2)
            SPO: SPCC1223.14
MOTIF       PS: PS00787  G-[DES]-S-H-[GC]-x(2)-[LIVM]-[GTIV]-x-[LIVT]-[LIV]-
                         [DEST]-G-x-[PV]
            PS: PS00788  [GE]-x(2)-S-[AG]-R-x-[ST]-x(3)-[VT]-x(2)-[GA]-[STAVY]-
                         [LIVMF]
            PS: PS00789  R-[SH]-D-[PSV]-[CSAV]-x(4)-[SGAIV]-x-[IVGSTAP]-[LIVM]-
                         x-E-[STAH]-[LIVMA]
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.4
            ExPASy - ENZYME nomenclature database: 4.6.1.4
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.4
            BRENDA, the Enzyme Database: 4.6.1.4
///
ENTRY       EC 4.6.1.5
NAME        Pentalenene synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     2-trans,6-trans-Farnesyldiphosphate pyrophosphate-lyase
            $ (cyclyzing, pentalenene-forming)
REACTION    2-trans,6-trans-Farnesyl diphosphate = Pentalenene + Pyrophosphate
SUBSTRATE   2-trans,6-trans-Farnesyl diphosphate
PRODUCT     Pentalenene
            Pyrophosphate
COMMENT     The initial step in the reaction is probably a cyclization of
            farnesyl diphosphate to form humulene. The enzyme is involved in
            the biosynthesis of pentalenolactone and related antibiotics.
STRUCTURES  PDB: 1PS1  
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.5
            ExPASy - ENZYME nomenclature database: 4.6.1.5
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.5
            BRENDA, the Enzyme Database: 4.6.1.5
            SCOP (Structural Classification of Proteins): 4.6.1.5
///
ENTRY       EC 4.6.1.6
NAME        Cytidylate cyclase
            3'5'-Cyclic-CMP synthase
            Cytidylyl cyclase
            Cytidyl cyclase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     CTP pyriphosphate-lyase (cyclizing)
REACTION    CTP = 3',5'-Cyclic CMP + Pyrophosphate
SUBSTRATE   CTP
PRODUCT     3',5'-Cyclic CMP
            Pyrophosphate
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.6
            ExPASy - ENZYME nomenclature database: 4.6.1.6
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.6
            BRENDA, the Enzyme Database: 4.6.1.6
///
ENTRY       EC 4.6.1.7
NAME        Casbene synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     Geranylgeranyl-diphosphate pyrophosphate-lyase (cyclizing)
REACTION    Geranylgeranyl diphosphate = Casbene + Pyrophosphate
SUBSTRATE   Geranylgeranyl diphosphate
PRODUCT     Casbene
            Pyrophosphate
COMMENT     The enzyme from castor bean (Ricinus communis) produces the
            antifungal diterpene casbene.
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.7
            ExPASy - ENZYME nomenclature database: 4.6.1.7
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.7
            BRENDA, the Enzyme Database: 4.6.1.7
///
ENTRY       EC 4.6.1.8
NAME        (-)-endo-Fenchol synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     Geranyl-diphosphate pyrophosphate-lyase (cyclizing,
            $ (-)-endo-fenchol-forming)
REACTION    Geranyl diphosphate = (-)-endo-Fenchol + Pyrophosphate
SUBSTRATE   Geranyl diphosphate
PRODUCT     (-)-endo-Fenchol
            Pyrophosphate
COMMENT     (3R)-Linalyl diphosphate is an intermediate in the reaction.
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.8
            ExPASy - ENZYME nomenclature database: 4.6.1.8
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.8
            BRENDA, the Enzyme Database: 4.6.1.8
///
ENTRY       EC 4.6.1.9
NAME        Sabinene-hydrate synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
SYSNAME     Geranyl-diphosphate pyrophosphate-lyase (cyclizing,
            $ sabinene-hydrate-forming)
REACTION    Geranyl diphosphate = Sabinene hydrate + Pyrophosphate
SUBSTRATE   Geranyl diphosphate
PRODUCT     Sabinene hydrate
            Pyrophosphate
COMMENT     Both cis- and trans- isomers of sabinene hydrate are formed.
            (3R)-Linalyl diphosphate is an intermediate in the reaction.
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.9
            ExPASy - ENZYME nomenclature database: 4.6.1.9
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.9
            BRENDA, the Enzyme Database: 4.6.1.9
///
ENTRY       EC 4.6.1.10
NAME        6-Pyruvoyl tetrahydrobiopterin synthase
            PTPS
CLASS       Lyases
            Phosphorus-oxygen lyases
            Elimination of pyrophosphate from nucleoside triphosphates
REACTION    2-Amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-
            $dihydroxypteridine triphosphate = 2-Amino-4-oxo-6-(1',2'-
            $dioxoprolyl)-7,8-dihydroxypteridine + Triphosphate
SUBSTRATE   2-Amino-4-oxo-6-(erythro-1',2',3'-trihydroxypropyl)-7,8-
            $dihydroxypteridine triphosphate
PRODUCT     2-Amino-4-oxo-6-(1',2'-dioxoprolyl)-7,8-dihydroxypteridine
            Triphosphate
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2765(ygcM)
            ECE: Z4075(ygcM)
            ECS: ECs3620
            YPE: YPO3373(ygcM)
            XFA: XF0193
            VCH: VC1299
            PAE: PA2666
            MLO: mll5797 mll8751
            SME: SMb20939(exsC)
            CCR: CC3158
            BSU: BG13313(ykvK)
            BHA: BH2243
            SAU: SA0666
            SAV: SAV0698
            SYN: slr0078
            TMA: TM0038
            AFU: AF0440
            HAL: VNG1024C
            PHO: PH0634
            PAB: PAB1445
            CEL: B0041.6
            DME: CG16784
            HSA: 5805(PTS)
DISEASE     MIM: 261640  6-pyruvoyltetrahydropterin synthase
MOTIF       PS: PS00987  C-N-N-x(2)-G-H-G-H-N-Y
            PS: PS00988  D-H-K-N-L-D-x-D
STRUCTURES  PDB: 1B6Z  1GTQ  1B66  
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.10
            ExPASy - ENZYME nomenclature database: 4.6.1.10
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.10
            SCOP (Structural Classification of Proteins): 4.6.1.10
///
ENTRY       EC 4.6.1.11
NAME        (+)-delta-Cadinene synthase
            D-Cadinene synthase
CLASS       Lyases
            Phosphorus-oxygen lyases
            Elimination of pyrophosphate from nucleoside triphosphates
REACTION    2-trans,6-trans-Farnesyl diphosphate = (+)-delta-Cadinene +
            Diphosphate
SUBSTRATE   2-trans,6-trans-Farnesyl diphosphate
PRODUCT     (+)-delta-Cadinene
            Diphosphate
COFACTOR    Magnesium
COMMENT     The sesquiterpenoid (+)-delta-cadinene is an intermediate in
            phytoalexin biosynthesis.
DBLINKS     IUBMB Enzyme Nomenclature: 4.6.1.11
            ExPASy - ENZYME nomenclature database: 4.6.1.11
            WIT (What Is There) Metabolic Reconstruction: 4.6.1.11
///
ENTRY       EC 4.99.1.1
NAME        Ferrochelatase
CLASS       Lyases
            Other lyases
SYSNAME     Protoheme ferro-lyase
REACTION    Protoporphyrin + Fe2+ = Protoheme + 2 H+
SUBSTRATE   Protoporphyrin
            Fe2+
PRODUCT     Protoheme
            H+
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b0475(hemH)
            ECE: Z0592(hemH)
            ECS: ECs0528
            YPE: YPO3117(hemH)
            HIN: HI1160(hemH)
            PMU: PM0789(hemH)
            XFA: XF0566
            VCH: VC0987
            PAE: PA4655(hemH)
            NME: NMB0718
            NMA: NMA0927(hemH)
            HPY: HP0376(hemH)
            HPJ: jhp1005
            CJE: Cj0503c(hemH)
            RPR: RP884(hemH)
            RCO: RC1373(hemH)
            MLO: mlr3019
            SME: SMc04019(hemH)
            CCR: CC3762
            BSU: BG10430(hemH)
            BHA: BH1203(hemH)
            SAU: SA1651(hemH)
            SAV: SAV1817(hemH)
            LLA: L0194(hemH)
            SPN: SP1009
            SPR: spr0914(hemH)
            MTU: Rv1485(hemZ)
            MTC: MT1532
            MLE: ML1805(hemZ)
            CTR: CT485
            CMU: TC0772
            CPN: CPn0603
            CPA: CP0144
            CPJ: hemZ
            SYN: slr0839(hemH)
            DRA: DR1131
            AAE: aq_948(hemH)
            TAC: Ta0311
            TVO: TVG1357926
            SCE: YOR176W(HEM15)
            SPO: SPCC320.09(spcc320.09)
            ATH: At2g30390(T6B20.24)
            DME: CG2098(ferrochelatase)
            MMU: 95513(Fech)
            HSA: 2235(FECH)
DISEASE     MIM: 177000  Ferrochelatase
MOTIF       PS: PS00534  [LIVMF](2)-x-[ST]-x-H-[GS]-[LIVM]-P-x(4,5)-[DENQKR]-x-
                         G-[DP]-x(1,2)-Y
STRUCTURES  PDB: 1AK1  1C1H  1C9E  1DOZ  1FJI  1HRK  
DBLINKS     IUBMB Enzyme Nomenclature: 4.99.1.1
            ExPASy - ENZYME nomenclature database: 4.99.1.1
            WIT (What Is There) Metabolic Reconstruction: 4.99.1.1
            BRENDA, the Enzyme Database: 4.99.1.1
            SCOP (Structural Classification of Proteins): 4.99.1.1
///
ENTRY       EC 4.99.1.2
NAME        Alkylmercury lyase
CLASS       Lyases
            Other lyases
SYSNAME     Alkylmercury mercuric-lyase
REACTION    RHg+ + H+ = RH + Hg2+
SUBSTRATE   RHg+
            H+
            Alkylmercury
            Arylmercury
PRODUCT     RH
            Hg2+
            Mercaptide
COMMENT     Acts on CH3Hg+ and a number of other alkylmercury and arylmercury
            compounds in the presence of cysteine or other thiols, liberating
            mercury as a mercaptide.
DBLINKS     IUBMB Enzyme Nomenclature: 4.99.1.2
            ExPASy - ENZYME nomenclature database: 4.99.1.2
            WIT (What Is There) Metabolic Reconstruction: 4.99.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 4.99.1.2
            BRENDA, the Enzyme Database: 4.99.1.2
///
ENTRY       EC 5.1.1.1
NAME        Alanine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Alanine racemase
REACTION    L-Alanine = D-Alanine
SUBSTRATE   L-Alanine
PRODUCT     D-Alanine
COFACTOR    Pyridoxal phosphate
INHIBITOR   3-Fluoro-D-alanine
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00473  D-Alanine metabolism
GENES       ECO: b1190(dadX) b4053(alr)
            ECE: Z1953(dadX) Z5651(alr)
            ECS: ECs1685 ECs5035
            YPE: YPO0321(alr) YPO1687
            HIN: HI1575(alr)
            PMU: PM0413(alr)
            XFA: XF0852
            VCH: VC0372 VC1312
            PAE: PA4930(alr) PA5302(dadX)
            NME: NMB1651
            NMA: NMA1906(alr)
            HPY: HP0941(alr)
            HPJ: jhp0876
            CJE: Cj0905c(alr)
            RPR: RP095(alr)
            RCO: RC0128(alr)
            MLO: mll3997 mll6211 mlr9371
            SME: SMc00557(alr)
            CCR: CC1661
            BSU: BG10950(alr) BG12267(yncD)
            BHA: BH0520
            SAU: SA1231 SA1874(alr)
            SAV: SAV1384 SAV2055(alr)
            LLA: L0103(dal)
            SPY: SPy1802(alr)
            SPN: SP1698
            SPR: spr1540(alr)
            CAC: CAC0492 CAC3331
            MTU: Rv3423c(alr)
            MTC: MT3532
            MLE: ML0375(alr)
            BBU: BB0160(alr)
            TPA: TP0681
            SYN: slr0827(alr)
            DRA: DR1086
            AAE: aq_1827(alr)
            SPO: SPCC965.08C(spcc965.08c)
MOTIF       PS: PS00395  [SAC]-[IV]-x-K-A-[DN]-[GA]-Y-G-[HAIL]-G
STRUCTURES  PDB: 1BD0  1SFT  2SFP  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.1
            ExPASy - ENZYME nomenclature database: 5.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.1
            BRENDA, the Enzyme Database: 5.1.1.1
            SCOP (Structural Classification of Proteins): 5.1.1.1
///
ENTRY       EC 5.1.1.2
NAME        Methionine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Methionine racemase
REACTION    L-Methionine = D-Methionine
SUBSTRATE   L-Methionine
PRODUCT     D-Methionine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.2
            ExPASy - ENZYME nomenclature database: 5.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.2
            BRENDA, the Enzyme Database: 5.1.1.2
///
ENTRY       EC 5.1.1.3
NAME        Glutamate racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Glutamate racemase
REACTION    L-Glutamate = D-Glutamate
SUBSTRATE   L-Glutamate
PRODUCT     D-Glutamate
COMMENT     Some enzymes require pyridoxal-phosphate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
GENES       ECO: b3967(murI)
            ECE: Z5528(murI)
            ECS: ECs4898
            YPE: YPO3909(murI)
            HIN: HI1739.2(murI)
            PMU: PM0917(murI)
            VCH: VC0158
            PAE: PA4662(murI)
            BUC: BU554(murI)
            NME: NMB0458
            NMA: NMA2026(glr)
            HPY: HP0549(muri)
            HPJ: jhp0496
            CJE: Cj1652c(murI)
            MLO: mlr0039
            SME: SMc00483(murI)
            CCR: CC3703
            BSU: BG11964(murI) BG12306(yrpC)
            BHA: BH3071
            SAU: SA0997(murI)
            SAV: SAV1133(murI)
            LLA: L0120(murI)
            SPY: SPy0361(glr)
            SPN: SP1881
            SPR: spr1696(murI)
            CAC: CAC3250
            MTU: Rv1338(murI)
            MTC: MT1379
            MLE: ML1172(murI)
            BBU: BB0100(murI)
            TPA: TP0406
            SYN: slr1746(murI)
            DRA: DR1586
            AAE: aq_325(murI)
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
            PS: PS00923  [IVA]-[LIVM]-x-C-x(0,1)-N-[ST]-[MSA]-[STH]-[LIVFYSTANK]
            PS: PS00924  [LIVM](2)-x-[AG]-C-T-[DEH]-[LIVMFY]-[PNGRS]-x-[LIVM]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
STRUCTURES  PDB: 1B74  1B73  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.3
            ExPASy - ENZYME nomenclature database: 5.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.3
            BRENDA, the Enzyme Database: 5.1.1.3
            SCOP (Structural Classification of Proteins): 5.1.1.3
///
ENTRY       EC 5.1.1.4
NAME        Proline racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Proline racemase
REACTION    L-Proline = D-Proline
SUBSTRATE   L-Proline
PRODUCT     D-Proline
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.4
            ExPASy - ENZYME nomenclature database: 5.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.4
            BRENDA, the Enzyme Database: 5.1.1.4
///
ENTRY       EC 5.1.1.5
NAME        Lysine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Lysine racemase
REACTION    L-Lysine = D-Lysine
SUBSTRATE   L-Lysine
PRODUCT     D-Lysine
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.5
            ExPASy - ENZYME nomenclature database: 5.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.5
            BRENDA, the Enzyme Database: 5.1.1.5
///
ENTRY       EC 5.1.1.6
NAME        Threonine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Threonine racemase
REACTION    L-Threonine = D-Threonine
SUBSTRATE   L-Threonine
PRODUCT     D-Threonine
COMMENT     Inverts both chiral centres.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.6
            ExPASy - ENZYME nomenclature database: 5.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.6
            BRENDA, the Enzyme Database: 5.1.1.6
///
ENTRY       EC 5.1.1.7
NAME        Diaminopimerate epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     LL-2,6-Diaminoheptanedioate 2-epimerase
REACTION    LL-2,6-Diaminoheptanedioate = meso-2,6-Diaminoheptanedioate
SUBSTRATE   LL-2,6-Diaminoheptanedioate
PRODUCT     meso-2,6-Diaminoheptanedioate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
GENES       ECO: b3809(dapF)
            ECE: Z5326(dapF)
            ECS: ECs4739
            YPE: YPO3845(dapF)
            HIN: HI0750(dapF)
            PMU: PM1703(dapF)
            XFA: XF1481
            VCH: VC0126
            PAE: PA5278(dapF)
            BUC: BU589(dapF)
            NME: NMB0760
            NMA: NMA0972(dapF)
            HPY: HP0566(dapF)
            HPJ: jhp0513
            CJE: Cj1531(dapF)
            RPR: RP415(dapF)
            RCO: RC0579(dapF)
            MLO: mlr4318
            SME: SMc03856(dapF)
            CCR: CC3686
            BSU: BG14048(dapF)
            BHA: BH3412
            CAC: CAC2624(dapF)
            MTU: Rv2726c(dapF)
            MTC: MT2798
            MLE: ML0996(dapF)
            CTR: CT430
            CMU: TC0714
            CPN: CPn0519
            CPA: CP0234
            CPJ: dapF
            SYN: slr1665(dapF)
            AAE: aq_1838(dapF)
            TMA: TM1522
            MJA: MJ1119(dapF)
            MTH: MTH1334
            AFU: AF0747(dapF)
MOTIF       PS: PS01326  N-x-D-G-S-x(4)-C-G-N-[GA]-x-R
STRUCTURES  PDB: 1BWZ  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.7
            ExPASy - ENZYME nomenclature database: 5.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.7
            BRENDA, the Enzyme Database: 5.1.1.7
            SCOP (Structural Classification of Proteins): 5.1.1.7
///
ENTRY       EC 5.1.1.8
NAME        4-Hydroxyproline epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     4-Hydroxyproline 2-epimerase
REACTION    trans-4-Hydroxy-L-proline = cis-4-Hydroxy-D-proline
SUBSTRATE   trans-4-Hydroxy-L-proline
            trans-4-Hydroxy-D-proline
PRODUCT     cis-4-Hydroxy-D-proline
            cis-4-Hydroxy-L-proline
COMMENT     Also interconverts trans-4-hydroxy-D-proline and cis-4-hydroxy-
            -L-proline.
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.8
            ExPASy - ENZYME nomenclature database: 5.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.8
            BRENDA, the Enzyme Database: 5.1.1.8
///
ENTRY       EC 5.1.1.9
NAME        Arginine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Arginine racemase
REACTION    L-Arginine = D-Arginine
SUBSTRATE   L-Arginine
PRODUCT     D-Arginine
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.9
            ExPASy - ENZYME nomenclature database: 5.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.9
            BRENDA, the Enzyme Database: 5.1.1.9
///
ENTRY       EC 5.1.1.10
NAME        Amino-acid racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Amino-acid racemase
REACTION    an L-Amino acid = a D-Amino acid
SUBSTRATE   L-Amino acid
PRODUCT     D-Amino acid
COFACTOR    Pyridoxal phosphate
COMMENT     A pyridoxal-phosphate protein.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00272  Cysteine metabolism
            PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00472  D-Arginine and D-ornithine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.10
            ExPASy - ENZYME nomenclature database: 5.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.10
            BRENDA, the Enzyme Database: 5.1.1.10
///
ENTRY       EC 5.1.1.11
NAME        Phenylalanine racemase (ATP-hydrolysing)
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Phenylalanine racemase (ATP-hydrolysing)
REACTION    ATP + L-Phenylalanine = AMP + Pyrophosphate + D-Phenylalanine
SUBSTRATE   ATP
            L-Phenylalanine
PRODUCT     AMP
            Pyrophosphate
            D-Phenylalanine
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
STRUCTURES  PDB: 1AMU  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.11
            ExPASy - ENZYME nomenclature database: 5.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.11
            BRENDA, the Enzyme Database: 5.1.1.11
            SCOP (Structural Classification of Proteins): 5.1.1.11
///
ENTRY       EC 5.1.1.12
NAME        Ornithine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Ornithine racemase
REACTION    L-Ornithine = D-Ornithine
SUBSTRATE   L-Ornithine
PRODUCT     D-Ornithine
PATHWAY     PATH: MAP00472  D-Arginine and D-ornithine metabolism
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.12
            ExPASy - ENZYME nomenclature database: 5.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.12
            BRENDA, the Enzyme Database: 5.1.1.12
///
ENTRY       EC 5.1.1.13
NAME        Aspartate racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Aspartate racemase
REACTION    L-Aspartate = D-Aspartate
SUBSTRATE   L-Aspartate
            L-Alanine
PRODUCT     D-Aspartate
            D-Alanine
COMMENT     Also acts, at half the rate, on L-alanine.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
GENES       YPE: YPO2758
            LLA: L92665(racD)
            AFU: AF1422
MOTIF       PS: PS00012  [DEQGSTALMKRH]-[LIVMFYSTAC]-[GNQ]-[LIVMFYAG]-[DNEKHS]-
                         S-[LIVMST]-{PCFY}-[STAGCPQLIVMF]-[LIVMATN]-
                         [DENQGTAKRHLM]-[LIVMWSTA]-[LIVGSTACR]-x(2)-[LIVMFA]
            PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
            PS: PS00923  [IVA]-[LIVM]-x-C-x(0,1)-N-[ST]-[MSA]-[STH]-[LIVFYSTANK]
            PS: PS00924  [LIVM](2)-x-[AG]-C-T-[DEH]-[LIVMFY]-[PNGRS]-x-[LIVM]
            PS: PS50075  Acyl carrier protein phosphopantetheine domain profile
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.13
            ExPASy - ENZYME nomenclature database: 5.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.13
            BRENDA, the Enzyme Database: 5.1.1.13
///
ENTRY       EC 5.1.1.14
NAME        Nocardicin-A epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
SYSNAME     Nocardicin-A epimerase
REACTION    Isonocardicin A = Nocardicin A
SUBSTRATE   Isonocardicin A
PRODUCT     Nocardicin A
COMMENT     The (9'S) configuration of isonocardicin A is converted into the
            (9'R) configuration.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.14
            ExPASy - ENZYME nomenclature database: 5.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.14
            BRENDA, the Enzyme Database: 5.1.1.14
///
ENTRY       EC 5.1.1.15
NAME        2-Amino-hexano-6-lactam racemase
            alpha-Amino-epsilon-caprolactam racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
REACTION    L-2-Amino-hexano-6-lactam = D-2-Amino-hexano-6-lactam
SUBSTRATE   L-2-Amino-hexano-6-lactam
PRODUCT     D-2-Amino-hexano-6-lactam
COMMENT     Also interconverts 2-Aminopentano-5-lactam (alpha-Amino-
            delta-Valerolactam) and 2-Amino-3-mercapto-hexano-6-lactam(
            alpha-Amino-beta-thio-epsilon-caprolactam).
            It does not catalyses the interconversion of alpha-Amino
            acids but has some transaminase activity with them.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.15
            ExPASy - ENZYME nomenclature database: 5.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.15
///
ENTRY       EC 5.1.1.16
NAME        Protein-serine epimerase
            Protein-serine racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on amino acids and derivatives
REACTION    [Protein]-L-serine = [Protein]-D-serine
SUBSTRATE   [Protein]-L-serine
PRODUCT     [Protein]-D-serine
COMMENT     The enzyme specifically interconverts the configuration of Ser-46
            of the peptide omega-agatoxin-KT, found in the venom of the funnel
            web spider, Agelenopsis aperta, but not that of the other serine
            residue, Ser-28.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.1.16
            ExPASy - ENZYME nomenclature database: 5.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 5.1.1.16
///
ENTRY       EC 5.1.2.1
NAME        Lactate racemase
            Lacticoracemase
            Hydroxyacid racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     Lactate racemase
REACTION    (S)-Lactate = (R)-Lactate
SUBSTRATE   (S)-Lactate
PRODUCT     (R)-Lactate
PATHWAY     PATH: MAP00620  Pyruvate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.1
            ExPASy - ENZYME nomenclature database: 5.1.2.1
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.1
            BRENDA, the Enzyme Database: 5.1.2.1
///
ENTRY       EC 5.1.2.2
NAME        Mandelate racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     Mandelate racemase
REACTION    (S)-Mandelate = (R)-Mandelate
SUBSTRATE   (S)-Mandelate
PRODUCT     (R)-Mandelate
COFACTOR    Magnesium
            Manganese
COMMENT     Sequence and three-dimensional structure are similarity to
            muconate cycloisomerase (EC 5.5.1.1); Biochemistry, 1990, 29,
            9856-9862; Nature, 1990, 347, 692-694. Both enzymes are
            functionally related to abstract the alpha-proton of carboxylic
            acids.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       MLO: mll7149
            SME: SMb21107(manR)
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
            PS: PS00909  [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-
                         [LIVM]-E-[DENQ]-P
STRUCTURES  PDB: 1DTN  1MDL  1MDR  1MNS  1MRA  2MNR  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.2
            ExPASy - ENZYME nomenclature database: 5.1.2.2
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.2
            UM-BBD (Biocatalysis/Biodegradation Database): 5.1.2.2
            BRENDA, the Enzyme Database: 5.1.2.2
            SCOP (Structural Classification of Proteins): 5.1.2.2
///
ENTRY       EC 5.1.2.3
NAME        3-Hydroxybutyryl-CoA epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     3-Hydroxybutanoyl-CoA 3-epimerase
REACTION    (S)-3-Hydroxybutanoyl-CoA = (R)-3-Hydroxybutanoyl-CoA
SUBSTRATE   (S)-3-Hydroxybutanoyl-CoA
PRODUCT     (R)-3-Hydroxybutanoyl-CoA
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00650  Butanoate metabolism
GENES       SME: SMc02227(fadB)
MOTIF       PS: PS00067  [DNE]-x(2)-[GA]-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-
                         [LIVMFY](2)-x(5)-[LIVMFYCT]-[LIVMFY]-x(2)-[GV]
            PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.3
            ExPASy - ENZYME nomenclature database: 5.1.2.3
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.3
            BRENDA, the Enzyme Database: 5.1.2.3
///
ENTRY       EC 5.1.2.4
NAME        Acetoin racemase
            Acetylmethylcarbinol racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     Acetoin racemase
REACTION    (S)-Acetoin = (R)-Acetoin
SUBSTRATE   (S)-Acetoin
PRODUCT     (R)-Acetoin
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.4
            ExPASy - ENZYME nomenclature database: 5.1.2.4
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.4
            BRENDA, the Enzyme Database: 5.1.2.4
///
ENTRY       EC 5.1.2.5
NAME        Tartrate epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     Tartrate epimerase
REACTION    (R,R)-Tartaric acid = meso-Tartaric acid
SUBSTRATE   (R,R)-Tartaric acid
PRODUCT     meso-Tartaric acid
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.5
            ExPASy - ENZYME nomenclature database: 5.1.2.5
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.5
            BRENDA, the Enzyme Database: 5.1.2.5
///
ENTRY       EC 5.1.2.6
NAME        Isocitrate epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on hydroxy acids and derivatives
SYSNAME     (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate 1-epimerase
REACTION    (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate =
            (1S,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
SUBSTRATE   (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
PRODUCT     (1S,2S)-1-Hydroxypropane-1,2,3-tricarboxylate
COMMENT     (1R,2S)-1-Hydroxypropane-1,2,3-tricarboxylate is the commonly
            occurring isomer of isocitrate.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.2.6
            ExPASy - ENZYME nomenclature database: 5.1.2.6
            WIT (What Is There) Metabolic Reconstruction: 5.1.2.6
            BRENDA, the Enzyme Database: 5.1.2.6
///
ENTRY       EC 5.1.3.1
NAME        Ribulose-phosphate 3-epimerase
            Phosphoribulose epimerase
            Erythrose-4-phosphate epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     D-Ribulose-5-phosphate 3-epimerase
REACTION    D-Ribulose 5-phosphate = D-Xylulose 5-phosphate
SUBSTRATE   D-Ribulose 5-phosphate
            D-Erythrose 4-phosphate
PRODUCT     D-Xylulose 5-phosphate
            D-Erythrulose 4-phosphate
            D-Threose 4-phosphate
COMMENT     The enzyme also converts D-erythrose 4-phosphate into
            D-erythrulose 4-phosphate and D-threose 4-phosphate.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00710  Carbon fixation
GENES       ECO: b3386(rpe)
            ECE: Z4739(rpe)
            ECS: ECs4228
            YPE: YPO0155(rpe)
            HIN: HI0566(rpe)
            PMU: PM1619(dod_2)
            XFA: XF0208
            VCH: VC2625
            PAE: PA0607(rpe)
            BUC: BU537(rpe)
            NME: NMB1244
            NMA: NMA1413(rpe)
            HPY: HP1386(rpe)
            HPJ: jhp1439
            CJE: Cj0451(rep)
            MLO: mlr4760
            SME: SMb20195(ppe) SMc00511(rpe)
            CCR: CC0101
            BSU: BG13393(rpe)
            BHA: BH2502
            SAU: SA1065(cfxE)
            SAV: SAV1209(cfxE)
            LLA: L0047(rpe)
            SPY: SPy0264(rpe)
            SPN: SP1983
            SPR: spr1797(rpe)
            CAC: CAC1730
            MGE: MG112
            MPN: K04_orf215(cfxE)
            MPU: MYPU_6830(rpe)
            UUR: UU456(rpe)
            MTU: Rv1408(rpe)
            MTC: MT1452
            MLE: ML0554(rpe)
            CTR: CT121
            CMU: TC0397
            CPN: CPn0185
            CPA: CP0583
            CPJ: rpe
            TPA: TP0945
            SYN: sll0807(rpe)
            DRA: DR1401
            AAE: aq_968(cbbE2)
            TMA: TM1718
            MJA: MJ0680(rpe)
            TAC: Ta1315
            TVO: TVG0278338
            SCE: YJL121C(RPE1)
            SPO: SPAC31G5.05C(spac31g5.05c)
            CEL: F08F8.4
            HSA: 6120(RPE)
MOTIF       PS: PS01085  [LIVMF]-H-[LIVMFY]-D-[LIVM]-x-D-x(1,2)-[FY]-[LIVM]-x-N-
                         x-[STAV]
            PS: PS01086  [LIVMA]-x-[LIVM]-M-[ST]-[VS]-x-P-x(3)-G-Q-x-[FM]-x(6)-
                         [NKR]-[LIVMC]
STRUCTURES  PDB: 1RPX  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.1
            ExPASy - ENZYME nomenclature database: 5.1.3.1
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.1
            BRENDA, the Enzyme Database: 5.1.3.1
            SCOP (Structural Classification of Proteins): 5.1.3.1
///
ENTRY       EC 5.1.3.2
NAME        UDPglucose 4-epimerase
            UDPgalactose 4-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDPglucose 4-epimerase
REACTION    UDPglucose = UDPgalactose
SUBSTRATE   UDPglucose
            UDP-2-deoxyglucose
PRODUCT     UDPgalactose
COFACTOR    NAD+
COMMENT     Requires NAD+. Also acts on UDP-2-deoxyglucose.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b0759(galE)
            ECE: Z0929(galE)
            ECS: ECs0787
            YPE: YPO1139(galE)
            HIN: HI0351(galE)
            PMU: PM0286(galE)
            VCH: VCA0774
            PAE: PA1384(galE) PA4068
            NME: NMB0064
            NMA: NMA0190(galE2') NMA0203(galE)
            HPY: HP0360
            HPJ: jhp1020
            CJE: Cj1131c(galE)
            MLO: mll1234 mll7878 mlr5697 mlr6767
            SME: SMb20459 SMb20942(exoB) SMc00430 SMc02252(galE)
            CCR: CC0092 CC2383
            BSU: BG11837(galE)
            BHA: BH1108(galE) BH2891 BH3379 BH3649
            SAU: SA0123
            SAV: SAV0122(galE)
            LLA: L0024(galE) L12335(ycbD)
            SPN: SP1607 SP1828
            SPR: spr1460(galE) spr1647(galE) spr1683(galE-truncation)
            CAC: CAC0794 CAC1429(galE) CAC2334 CAC2960(GalE)
            MGE: MG118(galE)
            MPN: A65_orf338(galE)
            MTU: Rv0501(galE1) Rv0536(galE2) Rv3468c(rmlB3) Rv3634c(rmlB2)
            MTC: MT0522 MT0560 MT3574 MT3736
            MLE: ML0204(rmlB2) ML2428
            SYN: sll0244(galE) slr1067(galE) slr1078(galE)
            DRA: DR0711 DR2202
            AAE: aq_1069(galE)
            TMA: TM0509
            MJA: MJ0211
            MTH: MTH375 MTH380 MTH631
            AFU: AF0361(galE-1) AF2016(galE-2)
            HAL: VNG0063G(galE2) VNG0065G(gmd) VNG0752G(galE1)
            TAC: Ta0011
            TVO: TVG0060866
            PHO: PH0378 PH1742
            PAB: PAB1299(galE-2) PAB2145(galE-1)
            SSO: SSO0166(galE-2) SSO0809(galE-2)
            STO: ST0187
            SCE: YBR019C(GAL10)
            SPO: SPBC365.14C(spbc365.14c)
            CEL: C47B2.6
            DME: CG12030
            HSA: 2582(GALE)
DISEASE     MIM: 230350  UDP galactose-4-epimerase
MOTIF       PS: PS00545  [NS]-x-T-N-H-x-Y-[FW]-N-[LI]
STRUCTURES  PDB: 1HZJ  1I3N  1KVQ  2UDP  1XEL  1A9Y  1A9Z  1EK5  1EK6  1UDC  
                 1I3K  1I3L  1I3M  1UDB  1UDA  1KVR  1KVS  1KVT  1KVU  1NAH  
                 1NAI  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.2
            ExPASy - ENZYME nomenclature database: 5.1.3.2
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.2
            BRENDA, the Enzyme Database: 5.1.3.2
            SCOP (Structural Classification of Proteins): 5.1.3.2
///
ENTRY       EC 5.1.3.3
NAME        Aldose 1-epimerase
            Mutarotase
            Aldose mutarotase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     Aldose 1-epimerase
REACTION    alpha-D-Glucose = beta-D-Glucose
SUBSTRATE   alpha-D-Glucose
            alpha-L-Arabinose
            alpha-D-Xylose
            alpha-D-Galactose
            alpha-Maltose
            alpha-Lactose
PRODUCT     beta-D-Glucose
            beta-L-Arabinose
            beta-D-Xylose
            beta-D-Galactose
            beta-Maltose
            beta-Lactose
COMMENT     Also acts on L-arabinose, D-xylose, D-galactose, maltose and
            lactose
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       ECO: b0756(galM)
            ECE: Z0926(galM)
            ECS: ECs0784
            YPE: YPO1135(galM)
            HIN: HI0818(galM)
            PMU: PM1034(galM)
            VCH: VC1594
            NME: NMB0389
            NMA: NMA2099(galM)
            MLO: mll1167
            SME: SMc03798(galM)
            CCR: CC1418
            BHA: BH2755
            SAU: SA2129
            SAV: SAV2323
            LLA: L0029(galM) L0232(xylM)
            SPN: SP0066
            SPR: spr0065(galM)
            CAC: CAC1349(galM)
            TMA: TM0282
            SCE: YBR019C(GAL10)
            CEL: C01B4.6
            DME: CG10467 CG10996 CG4988
MOTIF       PS: PS00545  [NS]-x-T-N-H-x-Y-[FW]-N-[LI]
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.3
            ExPASy - ENZYME nomenclature database: 5.1.3.3
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.3
            BRENDA, the Enzyme Database: 5.1.3.3
///
ENTRY       EC 5.1.3.4
NAME        L-Ribulose-phosphate 4-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     L-Ribulose-5-phosphate 4-epimerase
REACTION    L-Ribulose 5-phosphate = D-Xylulose 5-phosphate
SUBSTRATE   L-Ribulose 5-phosphate
PRODUCT     D-Xylulose 5-phosphate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b0061(araD)
            ECE: Z0069(araD)
            ECS: ECs0065
            YPE: YPO2230(araD) YPO3326(araD)
            HIN: HI1025(araD)
            PMU: PM1244(araD)
            VCH: VCA0244
            BSU: BG11906(araD)
            BHA: BH1871(araD)
            SPY: SPy0179(araD)
            SPN: SP2033
            SPR: spr1844(araD)
            CAC: CAC1341(araD)
            MPN: P02_orf242(araD)
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.4
            ExPASy - ENZYME nomenclature database: 5.1.3.4
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.4
            BRENDA, the Enzyme Database: 5.1.3.4
///
ENTRY       EC 5.1.3.5
NAME        UDParabinose 4-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDP-L-arabinose 4-epimerase
REACTION    UDP-L-arabinose = UDP-D-xylose
SUBSTRATE   UDP-L-arabinose
PRODUCT     UDP-D-xylose
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.5
            ExPASy - ENZYME nomenclature database: 5.1.3.5
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.5
            BRENDA, the Enzyme Database: 5.1.3.5
///
ENTRY       EC 5.1.3.6
NAME        UDPglucuronate 4-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDPglucuronate 4-epimerase
REACTION    UDPglucuronate = UDP-D-galacturonate
SUBSTRATE   UDPglucuronate
PRODUCT     UDP-D-galacturonate
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.6
            ExPASy - ENZYME nomenclature database: 5.1.3.6
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.6
            BRENDA, the Enzyme Database: 5.1.3.6
///
ENTRY       EC 5.1.3.7
NAME        UDP-N-acetylglucosamine 4-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDP-N-acetyl-D-glucosamine 4-epimerase
REACTION    UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine
SUBSTRATE   UDP-N-acetyl-D-glucosamine
PRODUCT     UDP-N-acetyl-D-galactosamine
PATHWAY     PATH: MAP00530  Aminosugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.7
            ExPASy - ENZYME nomenclature database: 5.1.3.7
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.7
            BRENDA, the Enzyme Database: 5.1.3.7
///
ENTRY       EC 5.1.3.8
NAME        N-Acylglucosamine 2-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     N-Acyl-D-glucosamine 2-epimerase
REACTION    N-Acyl-D-glucosamine = N-Acyl-D-mannosamine
SUBSTRATE   N-Acyl-D-glucosamine
PRODUCT     N-Acyl-D-mannosamine
COFACTOR    ATP
COMMENT     Requires catalytic amount of ATP.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       HSA: 5973(RENBP)
STRUCTURES  PDB: 1FP3  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.8
            ExPASy - ENZYME nomenclature database: 5.1.3.8
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.8
            BRENDA, the Enzyme Database: 5.1.3.8
            SCOP (Structural Classification of Proteins): 5.1.3.8
///
ENTRY       EC 5.1.3.9
NAME        N-Acylglucosamine-6-phosphate 2-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     N-Acyl-D-glucosamine-6-phosphate 2-epimerase
REACTION    N-Acyl-D-glucosamine 6-phosphate = N-Acyl-D-mannosamine 6-phosphate
SUBSTRATE   N-Acyl-D-glucosamine 6-phosphate
PRODUCT     N-Acyl-D-mannosamine 6-phosphate
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       MPU: MYPU_3630
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.9
            ExPASy - ENZYME nomenclature database: 5.1.3.9
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.9
            BRENDA, the Enzyme Database: 5.1.3.9
///
ENTRY       EC 5.1.3.10
NAME        CDPabequose epimerase
            CDPparatose epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     CDP-D-abequose 2-epimerase
REACTION    CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose
SUBSTRATE   CDP-3,6-dideoxy-D-glucose
PRODUCT     CDP-3,6-dideoxy-D-mannose
COFACTOR    NAD+
COMMENT     Requires NAD+.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.10
            ExPASy - ENZYME nomenclature database: 5.1.3.10
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.10
            BRENDA, the Enzyme Database: 5.1.3.10
///
ENTRY       EC 5.1.3.11
NAME        Cellobiose epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     Cellobiose 2-epimerase
REACTION    Cellobiose = D-Glucosyl-D-mannose
SUBSTRATE   Cellobiose
PRODUCT     D-Glucosyl-D-mannose
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.11
            ExPASy - ENZYME nomenclature database: 5.1.3.11
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.11
            BRENDA, the Enzyme Database: 5.1.3.11
///
ENTRY       EC 5.1.3.12
NAME        UDPglucuronate 5'-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDPglucuronate 5'-epimerase
REACTION    UDPglucuronate = UDP-L-iduronate
SUBSTRATE   UDPglucuronate
PRODUCT     UDP-L-iduronate
COFACTOR    NAD+
COMMENT     Requires NAD+.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.12
            ExPASy - ENZYME nomenclature database: 5.1.3.12
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.12
            BRENDA, the Enzyme Database: 5.1.3.12
///
ENTRY       EC 5.1.3.13
NAME        dTDP-4-dehydrorhamnose 3,5-epimerase
            dTDP-L-rhamnose synthetase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase
REACTION    dTDP-4-dehydro-6-deoxy-D-glucose =
            dTDP-4-dehydro-6-deoxy-L-mannose
SUBSTRATE   dTDP-4-dehydro-6-deoxy-D-glucose
PRODUCT     dTDP-4-dehydro-6-deoxy-L-mannose
COMMENT     The enzyme occurs in a complex with EC 1.1.1.113.
PATHWAY     PATH: MAP00520  Nucleotide sugars metabolism
GENES       ECO: b2038(rfbC)
            XFA: XF0257
            PAE: PA5164(rmlC)
            NME: NMB0081
            NMA: NMA0187(rfbC2) NMA0206(rfbC)
            CJE: Cj1430c
            MLO: mlr7551
            SME: SMb21325(expA8) SMb21428(rmlC)
            CCR: CC3633
            BSU: BG14195(spsL)
            BHA: BH3366(spsK)
            LLA: L198323(cpsM)
            SPY: SPy0935(cpsFP)
            SPR: spr0321(cps2M)
            CAC: CAC2331
            MTU: Rv3465(rmlC)
            MTC: MT3571
            MLE: ML1965(rmlC)
            SYN: slr0985(rfbC) slr1933(rfbC)
            DRA: DRA0043
            MTH: MTH1790
            TVO: TVG0949657
            PHO: PH0416
            PAB: PAB0787(rfbC)
            APE: APE1178
            SSO: SSO0833(rfbC-1) SSO1923(rfbC-2)
            CEL: C14F11.6
STRUCTURES  PDB: 1DZT  1DZR  1EP0  1EPZ  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.13
            ExPASy - ENZYME nomenclature database: 5.1.3.13
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.13
            BRENDA, the Enzyme Database: 5.1.3.13
            SCOP (Structural Classification of Proteins): 5.1.3.13
///
ENTRY       EC 5.1.3.14
NAME        UDP-N-acetylglucosamine 2-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDP-N-acetyl-D-glucosamine 2-epimerase
REACTION    UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine
SUBSTRATE   UDP-N-acetyl-D-glucosamine
PRODUCT     UDP-N-acetyl-D-mannosamine
COMMENT     The enzyme hydrolyses the product to UDP and N-acetyl-
            D-mannosamine.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b3786(wecB)
            ECE: Z5297(wecB)
            ECS: ECs4719
            YPE: YPO3864(rffE)
            PMU: PM1009(wbjD)
            VCH: VC0917
            PAE: PA3148(wbpI)
            NMA: NMA0199(sacA)
            RPR: RP334(rffE)
            RCO: RC0458(rffE)
            BSU: BG10403(yvyH)
            SAU: SA1913(mnaA)
            SAV: SAV2098(mnaA)
            LLA: L98310(ymjF)
            SPN: SP0357 SP0360
            CAC: CAC2874 CAC3064
            SYN: slr0624
            DRA: DR1561
            TMA: TM0610 TM1034
            MJA: MJ1504(wbpI)
            MTH: MTH837
            PHO: PH1617
            PAB: PAB0379(wlbD)
            HSA: 10020(GNE)
DISEASE     MIM: 603824  UDP-N-acetylglucosamine
                         2-epimerase/N-acetylmannosamine kinase
STRUCTURES  PDB: 1F6D  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.14
            ExPASy - ENZYME nomenclature database: 5.1.3.14
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.14
            BRENDA, the Enzyme Database: 5.1.3.14
            SCOP (Structural Classification of Proteins): 5.1.3.14
///
ENTRY       EC 5.1.3.15
NAME        Glucose-6-phosphate 1-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     D-Glucose-6-phosphate 1-epimerase
REACTION    alpha-D-Glucose 6-phosphate = beta-D-Glucose 6-phosphate
SUBSTRATE   alpha-D-Glucose 6-phosphate
PRODUCT     beta-D-Glucose 6-phosphate
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.15
            ExPASy - ENZYME nomenclature database: 5.1.3.15
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.15
            BRENDA, the Enzyme Database: 5.1.3.15
///
ENTRY       EC 5.1.3.16
NAME        UDPglucosamine epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     UDPglucosamine 4-epimerase
REACTION    UDPglucosamine = UDPgalactosamine
SUBSTRATE   UDPglucosamine
PRODUCT     UDPgalactosamine
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.16
            ExPASy - ENZYME nomenclature database: 5.1.3.16
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.16
            BRENDA, the Enzyme Database: 5.1.3.16
///
ENTRY       EC 5.1.3.17
NAME        Heparosan-N-sulfate-glucuronate 5-epimerase
            Heparosan epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     Poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl]
            $ glucurono-5-epimerase
REACTION    Heparosan-N-sulfate D-glucuronate = Heparosan-N-sulfate L-iduronate
SUBSTRATE   Heparosan-N-sulfate D-glucuronate
PRODUCT     Heparosan-N-sulfate L-iduronate
COMMENT     Acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine
            units in the heparin precursor, Not identical with EC 5.1.3.19.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.17
            ExPASy - ENZYME nomenclature database: 5.1.3.17
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.17
            BRENDA, the Enzyme Database: 5.1.3.17
///
ENTRY       EC 5.1.3.18
NAME        GDPmannose 3,5-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     GDPmannose 3,5-epimerase
REACTION    GDPmannose = GDP-L-galactose
SUBSTRATE   GDPmannose
PRODUCT     GDP-L-galactose
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.18
            ExPASy - ENZYME nomenclature database: 5.1.3.18
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.18
            BRENDA, the Enzyme Database: 5.1.3.18
///
ENTRY       EC 5.1.3.19
NAME        Chondroitin-glucuronate 5-epimerase
            Polyglucuronate 5-epimerase
            Dermatan-sulfate 5-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
SYSNAME     Chondroitin-D-glucuronate 5-epimerase
REACTION    Chondroitin-D-glucuronate = Dermatan L-iduronate
SUBSTRATE   Chondroitin-D-glucuronate
PRODUCT     Dermatan L-iduronate
COMMENT     Not identical with EC 5.1.3.17.
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.19
            ExPASy - ENZYME nomenclature database: 5.1.3.19
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.19
            BRENDA, the Enzyme Database: 5.1.3.19
///
ENTRY       EC 5.1.3.20
NAME        ADP-glyceromanno-heptose 6-epimerase
            ADP-L-glycero-D-manno-heptose 6-epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on carbohydrates and derivatives
REACTION    ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose
SUBSTRATE   ADP-D-glycero-D-manno-heptose
PRODUCT     ADP-L-glycero-D-manno-heptose
COFACTOR    NAD
GENES       ECO: b3619(rfaD)
            ECE: Z5046(rfaD)
            ECS: ECs4497
            YPE: YPO0058(rfaD)
            HIN: HI1114(rfaD)
            PMU: PM1342(rfaD)
            VCH: VC0240
            PAE: PA3337(rfaD)
            NME: NMB0828
            NMA: NMA1037(rfaD)
            HPY: HP0859(rfaD)
            HPJ: jhp0793
            CJE: Cj1151c(waaD)
            MLO: mlr2565
            CCR: CC1430
            AAE: aq_344(rfaD)
STRUCTURES  PDB: 1EQ2  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.3.20
            ExPASy - ENZYME nomenclature database: 5.1.3.20
            WIT (What Is There) Metabolic Reconstruction: 5.1.3.20
            SCOP (Structural Classification of Proteins): 5.1.3.20
///
ENTRY       EC 5.1.99.1
NAME        Methylmalonyl-CoA epimerase
            Methylmalonyl-CoA racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on other compounds
SYSNAME     2-Methyl-3-oxopropanoyl-CoA 2-epimerase
REACTION    (R)-2-Methyl-3-oxopropanoyl-CoA = (S)-2-Methyl-3-oxopropanoyl-CoA
SUBSTRATE   (R)-2-Methyl-3-oxopropanoyl-CoA
PRODUCT     (S)-2-Methyl-3-oxopropanoyl-CoA
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00640  Propanoate metabolism
STRUCTURES  PDB: 1JC4  1JC5  
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.99.1
            ExPASy - ENZYME nomenclature database: 5.1.99.1
            WIT (What Is There) Metabolic Reconstruction: 5.1.99.1
            BRENDA, the Enzyme Database: 5.1.99.1
///
ENTRY       EC 5.1.99.2
NAME        16-Hydroxysteroid epimerase
CLASS       Isomerases
            Racemases and epimerases
            Acting on other compounds
SYSNAME     16-Hydroxysteroid 16-epimerase
REACTION    16alpha-Hydroxysteroid = 16beta-Hydroxysteroid
SUBSTRATE   16alpha-Hydroxysteroid
PRODUCT     16beta-Hydroxysteroid
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.99.2
            ExPASy - ENZYME nomenclature database: 5.1.99.2
            WIT (What Is There) Metabolic Reconstruction: 5.1.99.2
            BRENDA, the Enzyme Database: 5.1.99.2
///
ENTRY       EC 5.1.99.3
NAME        Allantoin racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on other compounds
SYSNAME     Allantoin racemase
REACTION    (S)(+)-Allantoin = (R)(-)-Allantoin
SUBSTRATE   (S)(+)-Allantoin
PRODUCT     (R)(-)-Allantoin
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.99.3
            ExPASy - ENZYME nomenclature database: 5.1.99.3
            WIT (What Is There) Metabolic Reconstruction: 5.1.99.3
            BRENDA, the Enzyme Database: 5.1.99.3
///
ENTRY       EC 5.1.99.4
NAME        alpha-Methylacyl-CoA racemase
CLASS       Isomerases
            Racemases and epimerases
            Acting on other compounds
REACTION    (2S)-2-Methylacyl-CoA = (2R)-2-Methylacyl-CoA
SUBSTRATE   (2S)-2-Methylacyl-CoA
PRODUCT     (2R)-2-Methylacyl-CoA
COMMENT     Alpha-Methyl-branched acyl-CoA derivatives with chain
            lengths of more than C(10) serve as substrates.
            Also active towards some aromatic compounds (e.g. Ibuprofen)
            and Bile acid intermediates, such as Trihydroxycoprostanoyl-
            CoA. Not active towards free acids.
GENES       HSA: 23600(AMACR)
DISEASE     MIM: 604489  Alpha-methylacyl-CoA racemase
DBLINKS     IUBMB Enzyme Nomenclature: 5.1.99.4
            ExPASy - ENZYME nomenclature database: 5.1.99.4
            WIT (What Is There) Metabolic Reconstruction: 5.1.99.4
///
ENTRY       EC 5.2.1.1
NAME        Maleate isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     Maleate cis-trans-isomerase
REACTION    Maleic acid = Fumarate
SUBSTRATE   Maleic acid
PRODUCT     Fumarate
PATHWAY     PATH: MAP00650  Butanoate metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       SSO: SSO2939(maiA)
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.1
            ExPASy - ENZYME nomenclature database: 5.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.1
            BRENDA, the Enzyme Database: 5.2.1.1
///
ENTRY       EC 5.2.1.2
NAME        Maleylacetoacetate isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     4-Maleylacetoacetate cis-trans-isomerase
REACTION    4-Maleylacetoacetate = 4-Fumarylacetoacetate
SUBSTRATE   4-Maleylacetoacetate
PRODUCT     4-Fumarylacetoacetate
COMMENT     Also acts on maleylpyruvate.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00643  Styrene degradation
GENES       VCH: VC1347
            PAE: PA2007(maiA)
            SME: SMc03206(maiA)
            CEL: D1053.1
            DME: CG9362 CG9363
            HSA: 2954(GSTZ1)
STRUCTURES  PDB: 1FW1  
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.2
            ExPASy - ENZYME nomenclature database: 5.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.2
            UM-BBD (Biocatalysis/Biodegradation Database): 5.2.1.2
            BRENDA, the Enzyme Database: 5.2.1.2
///
ENTRY       EC 5.2.1.3
NAME        Retinal isomerase
            Retinene isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     all-trans-Retinal 11-cis-trans-isomerase
REACTION    all-trans-Retinal = 11-cis-Retinal
SUBSTRATE   all-trans-Retinal
PRODUCT     11-cis-Retinal
COMMENT     Light shifts the reaction towards the cis-isomer.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.3
            ExPASy - ENZYME nomenclature database: 5.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.3
            BRENDA, the Enzyme Database: 5.2.1.3
///
ENTRY       EC 5.2.1.4
NAME        Maleylpyruvate isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     3-Maleylpyruvate cis-trans-isomerase
REACTION    3-Maleylpyruvate = 3-Fumarylpyruvate
SUBSTRATE   3-Maleylpyruvate
PRODUCT     3-Fumarylpyruvate
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.4
            ExPASy - ENZYME nomenclature database: 5.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.4
            BRENDA, the Enzyme Database: 5.2.1.4
///
ENTRY       EC 5.2.1.5
NAME        Linoleate isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     Linolate delta12-cis-delta11-trans-isomerase
REACTION    9-cis,12-cis-Octadecadienoate = 9-cis,11-trans-Octadecadienoate
SUBSTRATE   9-cis,12-cis-Octadecadienoate
PRODUCT     9-cis,11-trans-Octadecadienoate
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.5
            ExPASy - ENZYME nomenclature database: 5.2.1.5
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.5
            BRENDA, the Enzyme Database: 5.2.1.5
///
ENTRY       EC 5.2.1.6
NAME        Furylfuramide isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase
REACTION    (E)-2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide =
            (Z)-2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide
SUBSTRATE   (E)-2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide
PRODUCT     (Z)-2-(2-Furyl)-3-(5-nitro-2-furyl)acrylamide
COFACTOR    NADH
COMMENT     Requires NADH.
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.6
            ExPASy - ENZYME nomenclature database: 5.2.1.6
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.6
            BRENDA, the Enzyme Database: 5.2.1.6
///
ENTRY       EC 5.2.1.7
NAME        Retinol isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     all-trans-Retinol 11-cis-trans-isomerase
REACTION    all-trans-Retinol = 11-cis-Retinol
SUBSTRATE   all-trans-Retinol
PRODUCT     11-cis-Retinol
COMMENT     Converts all-trans-retinol to 11-cis-retinol in the dark, thus
            reversing the effect of EC 5.2.1.3.
PATHWAY     PATH: MAP00830  Retinol metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.7
            ExPASy - ENZYME nomenclature database: 5.2.1.7
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.7
            BRENDA, the Enzyme Database: 5.2.1.7
///
ENTRY       EC 5.2.1.8
NAME        Peptidylprolyl isomerase
            Cyclophilin
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     Peptidylproline cis-trans-isomerase
REACTION    Peptidylproline (omega=180) = Peptidylproline (omega=0)
SUBSTRATE   Peptidylproline (omega=180)
PRODUCT     Peptidylproline (omega=0)
INHIBITOR   FK506
COMMENT     Catalyses one step in the refolding of urea-denatured ribonuclease
            A. The enzyme is identical with the protein which binds the
            immunosuppressive drug cyclosporin.
GENES       ECO: b0028(slpA) b0053(surA) b0441(ppiD) b0525(ppiB) b3347(fkpA)
                 b3349(slyD) b3363(ppiA) b3775(ppiC) b4207(fklB)
            ECE: Z0033(slpA) Z0062(surA) Z0548(ybaU) Z0680(ppiB) Z4705(fkpA)
                 Z4707(slyD) Z4724(ppiA) Z5286(ppiC) Z5818(fklB)
            ECS: ECs0031 ECs0058 ECs0495 ECs0587 ECs4198 ECs4200 ECs4214
                 ECs4709 ECs5185
            YPE: YPO0167(ppiA) YPO0193(slyD) YPO0195(fkpA) YPO0476a(fkpB)
                 YPO0494(surA) YPO3074(ppiB) YPO3153(ppiD) YPO3532(fklB)
                 YPO3873(ppiC)
            HIN: HI0079(ppiB) HI0458(surA) HI0574 HI0699(slyD) HI1004
            PMU: PM0943 PM0944(ppiB) PM1208(surA) PM1349(slyD) PM1567(fkpA)
                 PM1898 PM1979
            XFA: XF0644 XF0652 XF0838 XF1191 XF1212 XF1605
            VCH: VC0354 VC0445 VC0684 VC1849 VC1918 VC2299 VC2568 VC2604
                 VCA0661 VCA0953
            PAE: PA0594(surA) PA0699 PA0837(slyD) PA1793(ppiB) PA1805(ppiD)
                 PA1996(ppiC1) PA3227(ppiA) PA3262 PA3717 PA3871 PA4176(ppiC2)
                 PA4558 PA4572(fklB) PA5254
            BUC: BU140(surA) BU478(ppiD) BU533(fkpA)
            NME: NMB0027 NMB0281 NMB0791 NMB1238 NMB1262 NMB1522 NMB1567
            NMA: NMA0273(fbp) NMA0281 NMA1002(ppiB) NMA1407 NMA1469(ppiA)
                 NMA1722 NMA1756
            HPY: HP1123(slyD) HP1441(ppi)
            HPJ: jhp1052 jhp1334
            CJE: Cj0115(slyD) Cj1171c(ppi)
            MLO: mll0727 mll0728 mlr0613
            SME: SMc00234(ppiD) SMc01208(ppiB) SMc01700(ppiA)
            CCR: CC0979 CC1584 CC1688
            BSU: BG10512(ppiB)
            BHA: BH1545
            SAU: SA0815
            SAV: SAV0941
            LLA: L113864(ppiB) L168484(ppiA)
            SPY: SPy0457
            SPN: SP0771
            SPR: spr0679(ppiA)
            CAC: CAC2769(ppiB)
            MTU: Rv0009(ppiA) Rv2582(ppiB)
            MTC: MT0011 MT2659
            MLE: ML0011(ppiA) ML0492(ppiB)
            CTR: CT541
            CMU: TC0828
            CPN: CPn0661
            CPA: CP0086
            CPJ: mip
            TPA: TP0349 TP0862 TP0947
            SYN: sll0227(ppiB) slr1251(cyp) slr1761(ytfC)
            DRA: DR0237 DR1063 DR1839 DR1893 DR2464 DR2542
            AAE: aq_1694
            MJA: MJ0278 MJ0825(slyD)
            MTH: MTH1125 MTH1338
            AFU: AF1989(slyD)
            HAL: VNG1294G(slyD) VNG1914G(ppiA)
            TAC: Ta1011
            TVO: TVG0566451
            PHO: PH1399
            PAB: PAB1864(slyD)
            APE: APE0517
            SSO: SSO0758
            STO: ST0345
            SCE: YCR069W(SCC3) YDR155C(CPH1) YDR304C(CYP5) YDR519W(FKB2)
                 YHR057C(CYP2) YJR032W(CPR7) YLR216C(CPR6) YLR449W(FPR4)
                 YML074C(NPI46) YML078W(CPR3) YNL135C(FPR1) YNR028W(CPR8)
            SPO: FKBP39(fkbp39) PPI1(ppi1) SPAC21E11.05C(spac21e11.05c)
                 SPAC27F1.06C(spac27f1.06c) SPAC57A10.03(spac57a10.03)
                 SPBC16H5.05C(spbc16h5.05c) SPBC1709.04C(spbc1709.04c)
                 SPBC839.17C(spbc839.17c) SPBP8B7.25(spbp8b7.25)
                 SPCC553.04(spcc553.04)
            ATH: At2g29960(F23F1.12) At2g43560(T1O24.38) At4g34870(F11I11.110)
                 At4g38740(T9A14.20)
            CEL: B0252.4(cyp-10) C05C8.3 C34D4.12 C50F2.6 D1009.2(cyp-8)
                 F31D4.3 F36H1.1 F42G9.2(cyp-6) Y17G7B.9 Y75B12B.2 Y75B12B.5
                 cyp-11 cyp-4 cyp-7 cyp-9
            DME: CG10907 CG11001(FK506-bp2) CG11777 CG13892 CG14715
                 CG17051(dod) CG17266 CG2852 CG3966(ninaA) CG4535 CG4886(cyp33)
                 CG6226(FK506-bp1) CG7747 CG7768 CG9847(Fkbp13) CG9916(Cyp1)
            MMU: 104670(Fkbp5) 95541(Fkbp1)
            HSA: 10105(PPIF) 10450(PPIE) 10465(PPIH) 1574(CYP3A) 2280(FKBP1A)
                 2281(FKBP1B) 2286(FKBP2) 2287(FKBP3) 2288(FKBP4) 2289(FKBP5)
                 23759(PPIL2) 51303(LOC51303) 51645(PPIL1) 5300(PIN1)
                 5478(PPIA) 5479(PPIB) 5480(PPIC) 5481(PPID) 8468(FKBP6)
DISEASE     MIM: 123840  Peptidylprolyl isomerase A (cyclophilin A)
            MIM: 186945  FK506-binding protein-1A, 12kD
            MIM: 186946  FK506-binding protein-2, 13kD
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00170  [FY]-x(2)-[STCNLV]-x-F-H-[RH]-[LIVMN]-[LIVM]-x(2)-F-
                         [LIVM]-x-Q-[AG]-G
            PS: PS00453  [LIVMC]-x-[YF]-x-[GVL]-x(1,2)-[LFT]-x(2)-G-x(3)-[DE]-
                         [STAEQK]-[STAN]
            PS: PS00454  [LIVMFY]-x(2)-[GA]-x(3,4)-[LIVMF]-x(2)-[LIVMFHK]-x(2)-
                         G-x(4)-[LIVMF]-x(3)-[PSGAQ]-x(2)-[AG]-[FY]-G
            PS: PS01096  F-[GSADEI]-x-[LVAQ]-A-x(3)-[ST]-x(3,4)-[STQ]-x(3,5)-
                         [GER]-G-x-[LIVM]-[GS]
            PS: PS01159  W-x(9,11)-[VFY]-[FYW]-x(6,7)-[GSTNE]-[GSTQCR]-[FYW]-
                         x(2)-P
            PS: PS50020  WW/rsp5/WWP domain profile
            PS: PS50059  FKBP-type peptidyl-prolyl cis-
                         trans isomerase domain profile
            PS: PS50072  Cyclophilin-type peptidyl-prolyl cis-
                         trans isomerase profile
STRUCTURES  PDB: 1A33  1A7X  1AK4  1AWQ  1AWR  1AWS  1AWT  1AWU  1AWV  1B6C  
                 1BCK  1BKF  1BL4  1C5F  1CWF  1CWH  1CWI  1CWJ  1CWK  1CWL  
                 1CWM  1CWO  1D6O  1D7H  1D7I  1D7J  1DYW  1EYM  1F8A  1FAP  
                 1FD9  1FGL  1FKJ  1FKK  1FKL  1I6C  1I8G  1I8H  1IHG  1IIP  
                 1LOP  1NSG  1OCA  1PBK  1PIN  1QNG  1QNH  1RMH  1TCO  2FAP  
                 2NUL  2RMA  2RMB  3FAP  4FAP  
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.8
            ExPASy - ENZYME nomenclature database: 5.2.1.8
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.8
            BRENDA, the Enzyme Database: 5.2.1.8
            SCOP (Structural Classification of Proteins): 5.2.1.8
///
ENTRY       EC 5.2.1.9
NAME        Farnesol 2-isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     2-trans,6-trans-Farnesol 2-cis-trans-isomerase
REACTION    2-trans,6-trans-Farnesol = 2-cis,6-trans-Farnesol
SUBSTRATE   2-trans,6-trans-Farnesol
PRODUCT     2-cis,6-trans-Farnesol
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.9
            ExPASy - ENZYME nomenclature database: 5.2.1.9
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.9
            BRENDA, the Enzyme Database: 5.2.1.9
///
ENTRY       EC 5.2.1.10
NAME        2-Chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     2-Chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase
REACTION    cis-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide =
            trans-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide
SUBSTRATE   cis-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide
PRODUCT     trans-2-Chloro-4-carboxymethylenebut-2-en-1,4-olide
PATHWAY     PATH: MAP00627  1,4-Dichlorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.10
            ExPASy - ENZYME nomenclature database: 5.2.1.10
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.10
            BRENDA, the Enzyme Database: 5.2.1.10
///
ENTRY       EC 5.2.1.11
NAME        4-Hydroxyphenylacetaldehyde-oxime isomerase
CLASS       Isomerases
            cis-trans-Isomerases
SYSNAME     4-Hydroxyphenylacetaldehyde-oxime (E)-(Z)-isomerase
REACTION    (E)-4-Hydroxyphenylacetaldehyde-oxime =
            (Z)-4-Hydroxyphenylacetaldehyde-oxime
SUBSTRATE   (E)-4-Hydroxyphenylacetaldehyde-oxime
PRODUCT     (Z)-4-Hydroxyphenylacetaldehyde-oxime
COFACTOR    Thiol
COMMENT     Activated by thiols. Involved in the biosynthesis of the
            cyanogenic glucoside dhurrin in sorghum.
DBLINKS     IUBMB Enzyme Nomenclature: 5.2.1.11
            ExPASy - ENZYME nomenclature database: 5.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 5.2.1.11
            BRENDA, the Enzyme Database: 5.2.1.11
///
ENTRY       EC 5.3.1.1
NAME        Triose-phosphate isomerase
            Phosphotriose isomerase
            Triosephosphate mutase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Glyceraldehyde-3-phosphate ketol-isomerase
REACTION    D-Glyceraldehyde 3-phosphate = Glycerone phosphate
SUBSTRATE   D-Glyceraldehyde 3-phosphate
PRODUCT     Glycerone phosphate
INHIBITOR   2-Phosphoglycolate
            Phosphoglycolohydroxamate
COMMENT     2-Phosphoglycolate and phosphoglycolohydroxamate are transition
            state analogue/inhibitor. Crystal structures of the inhibitor
            complexes (Biochemistry, 1990, 29, 6619-6625; 1991, 30, 5821-5826;
            1994, 33, 2830-2837).
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00031  Inositol metabolism
            PATH: MAP00051  Fructose and mannose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00710  Carbon fixation
GENES       ECO: b3919(tpiA)
            ECE: Z5464(tpiA)
            ECS: ECs4844
            YPE: YPO0085(tpiA)
            HIN: HI0678(tpiA)
            PMU: PM1311(tpiA_1) PM1640(tpiA_2)
            XFA: XF0303
            VCH: VC2670
            PAE: PA4748(tpiA)
            BUC: BU307(tpiA)
            NME: NMB1887
            NMA: NMA0570(tpi)
            HPY: HP0194(tpia)
            HPJ: jhp0180
            CJE: Cj1401c(tpiA)
            MLO: mll0610 mlr7275
            SME: SMc01023(tpiA1) SMc01614(tpiA2)
            CCR: CC1893
            BSU: BG10897(tpi)
            BHA: BH3558(tpi)
            SAU: SA0729(tpi)
            SAV: SAV0761(tpi)
            LLA: L0006(tpiA)
            SPY: SPy0613(tpi)
            SPN: SP1574
            SPR: spr1432(tpi)
            CAC: CAC0711(tpi)
            MGE: MG431(tpia)
            MPN: C12_orf244(tim)
            MPU: MYPU_4580(tim)
            UUR: UU181(tpiA)
            MTU: Rv1438(tpi)
            MTC: MT1482
            MLE: ML0572(tpi)
            CTR: CT328
            CMU: TC0604
            CPN: CPn1063
            CPA: CP0786
            CPJ: tpiS
            BBU: BB0055(tpiA)
            TPA: TP0537
            SYN: slr0783(tpiA)
            DRA: DR1339
            AAE: aq_360(timA)
            TMA: TM0689
            MJA: MJ1528(tpiA)
            MTH: MTH1041
            AFU: AF1304(tpiA)
            HAL: VNG1027G(tpiA)
            TAC: Ta0313
            TVO: TVG1351870
            PHO: PH1884
            PAB: PAB1208(tpiA)
            APE: APE1538
            SSO: SSO2592(tpiA)
            SCE: YDR050C(TPI1)
            SPO: TPI1(tpi1)
            CEL: Y17G7B.7
            DME: CG2171(Tpi)
            MMU: 98797(Tpi)
            HSA: 7167(TPI1)
DISEASE     MIM: 190450  Triosephosphate isomerase-1
MOTIF       PS: PS00171  [AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]
STRUCTURES  PDB: 1AG1  1AMK  1AW1  1AW2  1B9B  1BTM  1CI1  1DKW  1HG3  1HTI  
                 1I45  1IF2  1IIG  1IIH  1ML1  1MSS  1MTM  1QDS  1TCD  1TIM  
                 1TMH  1TPB  1TPC  1TPD  1TPE  1TPF  1TPH  1TPU  1TPV  1TPW  
                 1TRD  1TRE  1TRI  1TSI  1TTI  1TTJ  1YDV  1YPI  2BTM  2YPI  
                 3TIM  3YPI  4TIM  5TIM  6TIM  7TIM  8TIM  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.1
            ExPASy - ENZYME nomenclature database: 5.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.1
            BRENDA, the Enzyme Database: 5.3.1.1
            SCOP (Structural Classification of Proteins): 5.3.1.1
///
ENTRY       EC 5.3.1.2
NAME        Deleted entry
            Erythrose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.2
            ExPASy - ENZYME nomenclature database: 5.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.2
///
ENTRY       EC 5.3.1.3
NAME        Arabinose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Arabinose ketol-isomerase
REACTION    D-Arabinose = D-Ribulose
SUBSTRATE   D-Arabinose
            L-Fucose
PRODUCT     D-Ribulose
COMMENT     Also acts on L-fucose and, more slowly, on L-galactose and
            D-altrose.
STRUCTURES  PDB: 1FUI  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.3
            ExPASy - ENZYME nomenclature database: 5.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.3
            BRENDA, the Enzyme Database: 5.3.1.3
            SCOP (Structural Classification of Proteins): 5.3.1.3
///
ENTRY       EC 5.3.1.4
NAME        L-Arabinose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     L-Arabinose ketol-isomerase
REACTION    L-Arabinose = L-Ribulose
SUBSTRATE   L-Arabinose
PRODUCT     L-Ribulose
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b0062(araA)
            ECE: Z0070(araA)
            ECS: ECs0066
            YPE: YPO2253(araA)
            BSU: BG11904(araA)
            BHA: BH1873(araA)
            CAC: CAC1342(araA) CAC1346(araA)
            TMA: TM0276
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.4
            ExPASy - ENZYME nomenclature database: 5.3.1.4
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.4
            BRENDA, the Enzyme Database: 5.3.1.4
///
ENTRY       EC 5.3.1.5
NAME        Xylose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Xylose ketol-isomerase
REACTION    D-Xylose = D-Xylulose;
            D-Glucose = D-Fructose
SUBSTRATE   D-Xylose
            D-Glucose
PRODUCT     D-Xylulose
            D-Fructose
COMMENT     Some enzymes also convert D-glucose to D-fructose.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
            PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b3565(xylA)
            ECE: Z4990(xylA)
            ECS: ECs4448
            YPE: YPO4038(xylA)
            HIN: HI1112(xylA)
            MLO: mlr5036 mlr5709
            SME: SMc03163(xylA)
            BSU: BG10806(xylA)
            BHA: BH2757(xylA)
            LLA: L0230(xylA)
            TMA: TM1071 TM1667
MOTIF       PS: PS00172  [LI]-E-P-K-P-x(2)-P
            PS: PS00173  [FL]-H-D-x-D-[LIV]-x-[PD]-x-[GDE]
STRUCTURES  PDB: 1XIJ  1XLC  9XIM  9XIA  8XIM  8XIA  7XIM  6XIM  6XIA  5XIN  
                 5XIM  5XIA  1A0C  1A0D  1A0E  1BHW  1BXB  1BXC  1CLK  1DID  
                 1DIE  1DXI  1QT1  1XIA  1XIB  1XIC  1XID  1XIE  1XIF  1XIG  
                 1XIH  1XII  4XIS  1XIM  1XIN  1XIS  1XLA  1XLB  4XIM  1XLD  
                 1XLE  1XLF  1XLG  1XLH  1XLI  1XLJ  1XLK  1XLL  1XLM  1XYA  
                 1XYB  1XYC  1XYL  1XYM  2GYI  2XIM  2XIN  2XIS  3XIM  3XIN  
                 3XIS  4XIA  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.5
            ExPASy - ENZYME nomenclature database: 5.3.1.5
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.5
            BRENDA, the Enzyme Database: 5.3.1.5
            SCOP (Structural Classification of Proteins): 5.3.1.5
///
ENTRY       EC 5.3.1.6
NAME        Ribose-5-phosphate epimerase
            Phosphopentoisomerase
            Phosphoriboisomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Ribose-5-phosphate ketol-isomerase
REACTION    D-Ribose 5-phosphate = D-Ribulose 5-phosphate
SUBSTRATE   D-Ribose 5-phosphate
            D-Ribose 5-diphosphate
            D-Ribose 5-triphosphate
PRODUCT     D-Ribulose 5-phosphate
COMMENT     Also acts on D-ribose 5-diphosphate and D-ribose 5-triphosphate.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00710  Carbon fixation
GENES       ECO: b2914(rpiA) b4090(rpiB)
            ECE: Z4252(rpiA)
            ECS: ECs3785
            YPE: YPO0915(rpiA) YPO1292(rpiA) YPO3353(rpiB)
            HIN: HI0464(rpiA)
            PMU: PM1645(rpiA_1) PM1670(rpiA_2)
            XFA: XF2015
            VCH: VC2480
            PAE: PA0330(rpiA)
            BUC: BU411(rpiA)
            NME: NMB1511
            NMA: NMA1711(rpiA)
            HPY: HP0574
            HPJ: jhp0521
            CJE: Cj0925(rpiB)
            RPR: RP299(lacA)
            RCO: RC0402(lacA)
            MLO: mll0526
            SME: SMc00152(rpiA) SMc01613(rpiB)
            CCR: CC2303
            BSU: BG10942(ywlF)
            BHA: BH3767
            SAU: SA2127
            SAV: SAV2321
            LLA: L0045(rpiA)
            SPY: SPy0889(rpiA)
            SPN: SP0828
            SPR: spr0731(rpiA)
            CAC: CAC0726 CAC1431(rpiA) CAC2880
            MGE: MG396(rpiB)
            MPN: D02_orf152(rpiB)
            MPU: MYPU_6120
            UUR: UU006(lacA)
            MTU: Rv2465c(rpi)
            MTC: MT2540
            MLE: ML1484
            CTR: CT213
            CMU: TC0485
            CPN: CPn0141
            CPA: CP0631
            CPJ: rpiA
            BBU: BB0657(rpi)
            TPA: TP0616
            SYN: slr0194(rpiA) ssl2153(rpiB)
            DRA: DR0845
            AAE: aq_1138(rpiB)
            TMA: TM1080
            MJA: MJ1603
            MTH: MTH608
            AFU: AF0943(rpi)
            HAL: VNG2272G(rpi)
            TAC: Ta0878
            TVO: TVG0723257
            PHO: PH1375
            PAB: PAB0522(rpi)
            APE: APE0665
            SSO: SSO0978(rpiA)
            STO: ST1302
            SCE: YOR095C(RKI1)
            SPO: SPAC144.12(spac144.12)
            CEL: B0280.3
            DME: CG9872
            MMU: 103254(Rpia)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.6
            ExPASy - ENZYME nomenclature database: 5.3.1.6
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.6
            BRENDA, the Enzyme Database: 5.3.1.6
///
ENTRY       EC 5.3.1.7
NAME        Mannose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Mannose ketol-isomerase
REACTION    D-Mannose = D-Fructose
SUBSTRATE   D-Mannose
            D-Lyxose
            D-Rhamnose
PRODUCT     D-Fructose
COMMENT     Also acts on D-lyxose and D-rhamnose.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.7
            ExPASy - ENZYME nomenclature database: 5.3.1.7
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.7
            BRENDA, the Enzyme Database: 5.3.1.7
///
ENTRY       EC 5.3.1.8
NAME        Mannose-6-phosphate isomerase
            Phosphomannose isomerase
            Phosphohexomutase
            Phosphohexoisomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Mannose-6-phosphate ketol-isomerase
REACTION    D-Mannose 6-phosphate = D-Fructose 6-phosphate
SUBSTRATE   D-Mannose 6-phosphate
PRODUCT     D-Fructose 6-phosphate
COFACTOR    Zinc
COMMENT     A zinc protein.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b1613(manA)
            ECE: Z2616(manA)
            ECS: ECs2319
            YPE: YPO2263(manA)
            PMU: PM0829(pmi)
            VCH: VC0269 VC1827
            SME: SMc03111(pmi)
            BSU: BG10454(pmi) BG12196(ydhS) BG13177(manA)
            BHA: BH3916
            SAU: SA1945 SA2435(pmi)
            SAV: SAV2129 SAV2626(pmi)
            LLA: L179409(pmi)
            SPY: SPy1810(pmi)
            SPN: SP0736
            SPR: spr0647(pmi)
            CAC: CAC2918(pmi)
            MPU: MYPU_7250(pmi)
            MTU: Rv3255c(manA)
            MTC: MT3353
            MLE: ML0765(manA)
            BBU: BB0407(manA)
            DRA: DRA0048
            TMA: TM0736
            AFU: AF0035
            SCE: YER003C(PMI40)
            SPO: SPBC2G2.16(spbc2g2.16)
            CEL: C05C8.7 ZK632.4
            DME: CG8417
            MMU: 97075(Mpi1)
            HSA: 4351(MPI)
DISEASE     MIM: 154550  Mannosephosphate isomerase (phosphomannose isomerase
                         1)
MOTIF       PS: PS00965  Y-x-D-x-N-H-K-P-E
            PS: PS00966  H-A-Y-[LIVM]-x-G-x(2)-[LIVM]-E-x-M-A-x-S-D-N-x-[LIVM]-
                         R-A-G-x-T-P-K
STRUCTURES  PDB: 1PMI  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.8
            ExPASy - ENZYME nomenclature database: 5.3.1.8
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.8
            BRENDA, the Enzyme Database: 5.3.1.8
            SCOP (Structural Classification of Proteins): 5.3.1.8
///
ENTRY       EC 5.3.1.9
NAME        Glucose-6-phosphate isomerase
            Phosphohexose isomerase
            Phosphohexomutase
            Oxoisomerase
            Hexosephosphate isomerase
            Phosphosaccharomutase
            Phosphoglucoisomerase
            Phosphohexoisomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Glucose-6-phosphate ketol-isomerase
REACTION    D-Glucose 6-phosphate = D-Fructose 6-phosphate;
            alpha-D-Glucose 6-phosphate = beta-D-Glucose 6-phosphate
SUBSTRATE   D-Glucose 6-phosphate
            alpha-D-Glucose 6-phosphate
PRODUCT     D-Fructose 6-phosphate
            beta-D-Glucose 6-phosphate
COMMENT     Also catalyses the anomerization of D-glucose 6-phosphate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b4025(pgi)
            ECE: Z5623(pgi)
            ECS: ECs5008
            YPE: YPO3718(pgi)
            HIN: HI1576(pgi)
            PMU: PM0416(pgi)
            XFA: XF0232
            VCH: VC0374
            PAE: PA4732(pgi)
            BUC: BU573(pgi)
            NME: NMB0334 NMB1388
            NMA: NMA1604(pgi1) NMA2154(pgi2)
            HPY: HP1166(pgi)
            HPJ: jhp1093
            CJE: Cj1535c(pgi)
            MLO: mlr5411
            SME: SMc02163(pgi)
            CCR: CC0222
            BSU: BG12366(pgi)
            BHA: BH3343(pgi)
            SAU: SA0823(pgi)
            SAV: SAV0949(gpiA)
            LLA: L0012(pgiA)
            SPY: SPy0215(pgi)
            SPN: SP2070
            SPR: spr1882(gpi)
            CAC: CAC2680(pgi)
            MGE: MG111(pgi)
            MPN: K04_orf430(pgiB)
            MPU: MYPU_1310(pgiB)
            MTU: Rv0946c(pgi)
            MTC: MT0972
            MLE: ML0150(pgi)
            CTR: CT378
            CMU: TC0657
            CPN: CPn1025
            CPA: CP0827
            CPJ: pgi
            BBU: BB0730(pgi)
            TPA: TP0475
            SYN: slr1349(pgi)
            DRA: DR1742
            AAE: aq_750(pgi)
            TMA: TM1385
            MJA: MJ1605
            HAL: VNG1992G(pgi)
            SCE: YBR196C(PGI1)
            SPO: PGI1(pgi1)
            DME: CG8251(Pgi)
            MMU: 95797(Gpi1) 95798(Gpi1-r) 95799(Gpi1-s) 95800(Gpi1-t)
            HSA: 2821(GPI)
DISEASE     MIM: 172400  Glucose phosphate isomerase; neuroleukin
MOTIF       PS: PS00174  [GS]-x-[LIVM]-[LIVMFYW]-x(4)-[FY]-[DN]-Q-x-G-V-[EQ]-
                         x(2)-K
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
            PS: PS00765  [DENS]-x-[LIVM]-G-G-R-[FY]-S-[LIVMTP]-x-[STA]-[PSAC]-
                         [LIVMA]-G
STRUCTURES  PDB: 1C7R  1DQR  1G98  1HOX  1IAT  1PGI  2PGI  1C7Q  1B0Z  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.9
            ExPASy - ENZYME nomenclature database: 5.3.1.9
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.9
            BRENDA, the Enzyme Database: 5.3.1.9
            SCOP (Structural Classification of Proteins): 5.3.1.9
///
ENTRY       EC 5.3.1.10
NAME        Glucosamine-6-phosphate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Glucosamine-6-phosphate ketol-isomerase(deaminating)
REACTION    D-Glucosamine 6-phosphate + H2O = D-Fructose 6-phosphate + NH3
SUBSTRATE   D-Glucosamine 6-phosphate
            H2O
PRODUCT     D-Fructose 6-phosphate
            NH3
EFFECTOR    N-Acetyl-D-glucosamine 6-phosphate
COMMENT     N-Acetyl-D-glucosamine 6-phosphate, which is not broken down,
            activates the enzyme.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       YPE: YPO2627(nagB)
MOTIF       PS: PS01161  [LIVM]-x(3)-G-x-[LITC]-x-[LIV]-x-[LIVM]-x-G-[LIVM]-G-x-
                         [DEN]-G-H
STRUCTURES  PDB: 1CD5  1D9T  1HOT  1HOR  1DEA  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.10
            ExPASy - ENZYME nomenclature database: 5.3.1.10
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.10
            BRENDA, the Enzyme Database: 5.3.1.10
            SCOP (Structural Classification of Proteins): 5.3.1.10
///
ENTRY       EC 5.3.1.11
NAME        Deleted entry
            Acetylglucosaminephosphate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.11
            ExPASy - ENZYME nomenclature database: 5.3.1.11
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.11
///
ENTRY       EC 5.3.1.12
NAME        Glucuronate isomerase
            Uronic isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Glucuronate ketol-isomerase
REACTION    D-Glucuronate = D-Fructuronate;
            D-Galacturonate = D-Tagaturonate
SUBSTRATE   D-Glucuronate
            D-Galacturonate
PRODUCT     D-Fructuronate
            D-Tagaturonate
COMMENT     Also converts D-galacturonate to D-tagaturonate.
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b3092(uxaC)
            ECE: Z4445(uxaC)
            ECS: ECs3974
            YPE: YPO0579(uxaC)
            SME: SMb21354(uxaC)
            CCR: CC1490
            BSU: BG13204(uxaC)
            BHA: BH0705
            LLA: L0019(uxaC)
            CAC: CAC0692(uxaC)
            TMA: TM0064
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.12
            ExPASy - ENZYME nomenclature database: 5.3.1.12
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.12
            BRENDA, the Enzyme Database: 5.3.1.12
///
ENTRY       EC 5.3.1.13
NAME        Arabinose-5-phosphate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Arabinose-5-phosphate ketol-isomerase
REACTION    D-Arabinose 5-phosphate = D-Ribulose 5-phosphate
SUBSTRATE   D-Arabinose 5-phosphate
PRODUCT     D-Ribulose 5-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.13
            ExPASy - ENZYME nomenclature database: 5.3.1.13
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.13
            BRENDA, the Enzyme Database: 5.3.1.13
///
ENTRY       EC 5.3.1.14
NAME        L-Rhamnose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     L-Rhamnose ketol-isomerase
REACTION    L-Rhamnose = L-Rhamnulose
SUBSTRATE   L-Rhamnose
PRODUCT     L-Rhamnulose
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b3903(rhaA)
            ECE: Z5447(rhaA)
            ECS: ECs4830
            YPE: YPO0329(rhaA)
            BSU: BG12387(yulE)
            BHA: BH1552
STRUCTURES  PDB: 1DE6  1DE5  1D8W  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.14
            ExPASy - ENZYME nomenclature database: 5.3.1.14
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.14
            BRENDA, the Enzyme Database: 5.3.1.14
            SCOP (Structural Classification of Proteins): 5.3.1.14
///
ENTRY       EC 5.3.1.15
NAME        D-Lyxose ketol-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Lyxose ketol-isomerase
REACTION    D-Lyxose = D-Xylulose
SUBSTRATE   D-Lyxose
PRODUCT     D-Xylulose
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
STRUCTURES  PDB: 1QO2  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.15
            ExPASy - ENZYME nomenclature database: 5.3.1.15
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.15
            BRENDA, the Enzyme Database: 5.3.1.15
            SCOP (Structural Classification of Proteins): 5.3.1.15
///
ENTRY       EC 5.3.1.16
NAME        N-(5'-Phospho-D-ribosylformimino)-5-amino-1-
            $(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     N-(5'-Phospho-D-ribosylformimino)-5-amino-1-
            $(5''-phosphoribosyl)-4-imidazolecarboxamide ketol-isomerase
REACTION    N-(5'-Phospho-D-ribosylformimino)-5-amino-1-
            $(5''-phospho-D-ribosyl)-4-imidazolecarboxamide =
            N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-
            $(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
SUBSTRATE   N-(5'-Phospho-D-ribosylformimino)-5-amino-1-
            $(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
PRODUCT     N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-
            $(5''-phospho-D-ribosyl)-4-imidazolecarboxamide
PATHWAY     PATH: MAP00340  Histidine metabolism
GENES       ECO: b2024(hisA)
            ECE: Z3186(hisA)
            ECS: ECs2825
            YPE: YPO1544(hisA)
            HIN: HI0473(hisA)
            PMU: PM1203(hisA)
            XFA: XF2215
            VCH: VC1137
            PAE: PA5141(hisA)
            BUC: BU104(hisA)
            NME: NMB0629
            NMA: NMA0839(hisA)
            CJE: Cj1601(hisA)
            MLO: mlr5014
            SME: SMc02570(hisA)
            CCR: CC3736
            BSU: BG12597(hisA)
            BHA: BH3579(hisA)
            SAU: SA2466
            SAV: SAV2659(hisA)
            LLA: L0070(hisA)
            CAC: CAC0940(hisA)
            MTU: Rv1603(hisA)
            MTC: MT1639
            MLE: ML1261(hisA)
            SYN: slr0652(hisA)
            DRA: DR2495
            AAE: aq_1303(hisA)
            TMA: TM1037
            MJA: MJ0703 MJ1532(hisA)
            MTH: MTH669 MTH843
            AFU: AF0713(hisA-1) AF0986(hisA-2)
            HAL: VNG2294G(hisA)
            SSO: SSO0594(hisA)
            SCE: YIL020C(HIS6)
            SPO: SPAC3F10.09(spac3f10.09)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.16
            ExPASy - ENZYME nomenclature database: 5.3.1.16
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.16
            BRENDA, the Enzyme Database: 5.3.1.16
///
ENTRY       EC 5.3.1.17
NAME        4-Deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     4-Deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
REACTION    4-Deoxy-L-threo-5-hexosulose uronate =
            3-Deoxy-D-glycero-2,5-dexodiulosonate
SUBSTRATE   4-Deoxy-L-threo-5-hexosulose uronate
PRODUCT     3-Deoxy-D-glycero-2,5-dexodiulosonate
PATHWAY     PATH: MAP00040  Pentose and glucuronate interconversions
GENES       ECO: b2843(kduI)
            ECE: Z4163(kduI)
            ECS: ECs3700
            YPE: YPO1725(kduI)
            SME: SMb21349
            CCR: CC1491
            BSU: BG11401(kduI)
            BHA: BH2166(kduI)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.17
            ExPASy - ENZYME nomenclature database: 5.3.1.17
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.17
            BRENDA, the Enzyme Database: 5.3.1.17
///
ENTRY       EC 5.3.1.18
NAME        Deleted entry
            Glucose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
COMMENT     Deleted entry. (reaction due to EC 5.3.1.9, in presence of
            arsenate, or EC 5.3.1.5.)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.18
            ExPASy - ENZYME nomenclature database: 5.3.1.18
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.18
///
ENTRY       EC 5.3.1.19
NAME        Transferred to EC 2.6.1.16
            Glutamine--fructose-6-phosphate transaminase (isomerizing)
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
COMMENT     Transferred entry.
            Now EC 2.6.1.16 -
            Glutamine--fructose-6-phosphate transaminase (isomerizing).
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.19
            ExPASy - ENZYME nomenclature database: 5.3.1.19
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.19
///
ENTRY       EC 5.3.1.20
NAME        Ribose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     D-Ribose ketol-isomerase
REACTION    D-Ribose = D-Ribulose
SUBSTRATE   D-Ribose
            L-Lyxose
            L-Rhamnose
PRODUCT     D-Ribulose
COMMENT     Also acts on L-lyxose and L-rhamnose.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.20
            ExPASy - ENZYME nomenclature database: 5.3.1.20
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.20
            BRENDA, the Enzyme Database: 5.3.1.20
///
ENTRY       EC 5.3.1.21
NAME        Corticosteroid side-chain-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     11-Deoxycorticosterone ketol-isomerase
REACTION    11-Deoxycorticosterone = 20-Hydroxy-3-oxopregn-4-en-21-al
SUBSTRATE   11-Deoxycorticosterone
PRODUCT     20-Hydroxy-3-oxopregn-4-en-21-al
COMMENT     An epimerization at C20 and C21 is probably catalysed by the
            same enzyme.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.21
            ExPASy - ENZYME nomenclature database: 5.3.1.21
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.21
            BRENDA, the Enzyme Database: 5.3.1.21
///
ENTRY       EC 5.3.1.22
NAME        Hydroxypyruvate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     Hydroxypyruvate ketol-isomerase
REACTION    Hydroxypyruvate = 2-Hydroxy-3-oxopropanoate
SUBSTRATE   Hydroxypyruvate
PRODUCT     2-Hydroxy-3-oxopropanoate
GENES       ECO: b0508(GIP)
            SME: SMb20680(hyi)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.22
            ExPASy - ENZYME nomenclature database: 5.3.1.22
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.22
            BRENDA, the Enzyme Database: 5.3.1.22
///
ENTRY       EC 5.3.1.23
NAME        5-Methylthioribose-1-phosphate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     5-Methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase
REACTION    5-Methylthio-5-deoxy-D-ribose 1-phosphate =
            5-Methylthio-5-deoxy-D-ribulose 1-phosphate
SUBSTRATE   5-Methylthio-5-deoxy-D-ribose 1-phosphate
PRODUCT     5-Methylthio-5-deoxy-D-ribulose 1-phosphate
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.23
            ExPASy - ENZYME nomenclature database: 5.3.1.23
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.23
            BRENDA, the Enzyme Database: 5.3.1.23
///
ENTRY       EC 5.3.1.24
NAME        Phosphoribosylanthranilate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
SYSNAME     N-(5-Phospho-beta-D-ribosyl)anthranilate ketol-isomerase
REACTION    N-(5-Phospho-beta-D-ribosyl)anthranilate =
            1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
SUBSTRATE   N-(5-Phospho-beta-D-ribosyl)anthranilate
PRODUCT     1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
COMMENT     In some organisms, this enzyme is part of a multifunctional
            protein, together with one or more other components of the system
            for the biosynthesis of tryptophan (EC 2.4.2.18, 4.1.1.48,
            4.1.3.27, 4.2.1.20).
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b1262(trpC)
            ECE: Z2549(trpC)
            ECS: ECs1834
            HIN: HI1389.1(trpC)
            PMU: PM0580(trpC)
            XFA: XF1374
            VCH: VC1171
            PAE: PA3113(trpF)
            BUC: BU279(trpC)
            NME: NMB0688
            NMA: NMA0890(trpF)
            HPY: HP1279(trpC)
            HPJ: jhp1200
            CJE: Cj0347(trpF)
            MLO: mlr5070
            SME: SMc02767(trpF)
            CCR: CC3545
            BSU: BG10289(trpF)
            BHA: BH1662(trpF)
            SAU: SA1203(trpF)
            SAV: SAV1356(trpF)
            LLA: L0050(trpF)
            SPN: SP1813
            SPR: spr1633(trpF)
            CAC: CAC3159(trpF)
            CTR: CT327
            CMU: TC0603
            SYN: sll0356(trpF)
            DRA: DR0123
            AAE: aq_2076(trpF)
            TMA: TM0139
            MJA: MJ0451(tprF)
            MTH: MTH1658(trpF)
            AFU: AF1601(trpF)
            HAL: VNG1648G(trpF)
            TAC: Ta0805
            TVO: TVG1080245
            PAB: PAB2047(trpF)
            APE: APE2547
            SSO: SSO0892(trpF)
            STO: ST1230
            SCE: YDR007W(TRP1)
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00614  [LIVMFY]-[LIVMC]-x-E-[LIVMFYC]-K-[KRSP]-[STAHKR]-S-P-
                         [ST]-x(3)-[LIVMFYST]
STRUCTURES  PDB: 1PII  1NSJ  1DL3  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.24
            ExPASy - ENZYME nomenclature database: 5.3.1.24
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.24
            BRENDA, the Enzyme Database: 5.3.1.24
            SCOP (Structural Classification of Proteins): 5.3.1.24
///
ENTRY       EC 5.3.1.25
NAME        L-Fucose isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
REACTION    L-Fucose = L-Fuculose
SUBSTRATE   L-Fucose
PRODUCT     L-Fuculose
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2802(fucI)
            ECE: Z4119(fucI)
            ECS: ECs3662
            HIN: HI0614(fucI)
            SPN: SP2158
            SPR: spr1964(fucI)
            TMA: TM0307
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.25
            ExPASy - ENZYME nomenclature database: 5.3.1.25
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.25
///
ENTRY       EC 5.3.1.26
NAME        Galactose-6-phosphate isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting aldoses and ketoses
REACTION    D-Galactose 6-phosphate = D-Tagatose 6-phosphate
SUBSTRATE   D-Galactose 6-phosphate
PRODUCT     D-Tagatose 6-phosphate
COMMENT     Involved in the tagatose 6-phosphate pathway of lactose catabolism
            in bacteria.
PATHWAY     PATH: MAP00052  Galactose metabolism
GENES       SAU: SA1996(lacB) SA1997(lacA)
            SAV: SAV2180(lacB) SAV2181(lacA)
            SPY: SPy1707(lacB.1) SPy1708(lacA.1) SPy1922(lacB.2)
                 SPy1923(lacA.2)
            SPN: SP1192 SP1193
            SPR: spr1075(lacB) spr1076(lacA)
            CAC: CAC2953(lacB) CAC2954(lacA)
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.1.26
            ExPASy - ENZYME nomenclature database: 5.3.1.26
            WIT (What Is There) Metabolic Reconstruction: 5.3.1.26
///
ENTRY       EC 5.3.2.1
NAME        Phenylpyruvate tautomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting keto- and enol-groups
SYSNAME     Phenylpyruvate keto-enol-isomerase
REACTION    keto-Phenylpyruvate = enol-Phenylpyruvate;
            4-Hydroxyphenylpyruvate = 2-Hydroxy-3-(4-hydroxyphenyl)propenoate
SUBSTRATE   keto-Phenylpyruvate
            4-Hydroxyphenylpyruvate
PRODUCT     enol-Phenylpyruvate
            2-Hydroxy-3-(4-hydroxyphenyl)propenoate
COMMENT     Also acts on other arylpyruvate.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.2.1
            ExPASy - ENZYME nomenclature database: 5.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.2.1
            BRENDA, the Enzyme Database: 5.3.2.1
///
ENTRY       EC 5.3.2.2
NAME        Oxaloacetate tautomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Interconverting keto- and enol-groups
SYSNAME     Oxaloacetate keto-enol-isomerase
REACTION    Oxaloacetate = enol-Oxaloacetate
SUBSTRATE   Oxaloacetate
PRODUCT     enol-Oxaloacetate
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.2.2
            ExPASy - ENZYME nomenclature database: 5.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 5.3.2.2
            BRENDA, the Enzyme Database: 5.3.2.2
///
ENTRY       EC 5.3.3.1
NAME        Steroid delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     3-Oxosteroid delta5-delat4-isomerase
REACTION    a 3-Oxo-delta5-steroid = a 3-Oxo-delta4-steroid
SUBSTRATE   3-Oxo-delta5-steroid
PRODUCT     3-Oxo-delta4-steroid
COMMENT     May be at least three distinct enzymes.
PATHWAY     PATH: MAP00140  C21-Steroid hormone metabolism
            PATH: MAP00150  Androgen and estrogen metabolism
GENES       SCE: YGL001C(ERG26)
            SPO: SPBC3F6.02C(spbc3f6.02c)
            MMU: 96233(Hsd3b1)
            HSA: 3283(HSD3B1) 3284(HSD3B2)
DISEASE     MIM: 109715  Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                         steroid
            MIM: 201810  Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and
                         steroid
STRUCTURES  PDB: 1BUQ  1C7H  1DMM  1DMN  1DMQ  1E97  1ISK  1OPY  4TSU  8CHO  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.1
            ExPASy - ENZYME nomenclature database: 5.3.3.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.1
            BRENDA, the Enzyme Database: 5.3.3.1
            SCOP (Structural Classification of Proteins): 5.3.3.1
///
ENTRY       EC 5.3.3.2
NAME        Isopentenyl-diphosphate delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Isopentenyl-diphosphate delta3-delta2-isomerase
REACTION    Isopentenyl diphosphate = Dimethylallyl diphosphate
SUBSTRATE   Isopentenyl diphosphate
PRODUCT     Dimethylallyl diphosphate
PATHWAY     PATH: MAP00100  Sterol biosynthesis
            PATH: MAP00900  Terpenoid biosynthesis
GENES       ECO: b2889
            ECE: Z4227
            ECS: ECs3761
            BSU: BG11440(ypgA)
            SAU: SA2136(fni)
            SAV: SAV2331
            LLA: L11083(yebB)
            SPY: SPy0879
            SPN: SP0384
            SPR: spr0341(fni)
            MTU: Rv1745c
            MTC: MT1787
            BBU: BB0684
            SYN: sll1556
            DRA: DR1087
            MJA: MJ0862
            MTH: MTH48
            AFU: AF2287
            HAL: VNG1818G(idi) VNG6081G(crt_1) VNG6445G(crt_2)
            TAC: Ta0102
            TVO: TVG0186390
            PHO: PH1202
            PAB: PAB1662
            APE: APE1765
            SSO: SSO0063
            SCE: YPL117C(IDI1)
            SPO: IDI1(idi1)
            ATH: At3g02780(F13E7.28) At5g16440(MQK4.17)
            DME: CG5919
            HSA: 3422(IDI1)
STRUCTURES  PDB: 1HX3  1HZT  1I9A  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.2
            ExPASy - ENZYME nomenclature database: 5.3.3.2
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.2
            BRENDA, the Enzyme Database: 5.3.3.2
///
ENTRY       EC 5.3.3.3
NAME        Vinylacetyl-CoA delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Vinylacetyl-CoA delta3-delta2-isomerase
REACTION    Vinylacetyl-CoA = Crotonoyl-CoA
SUBSTRATE   Vinylacetyl-CoA
            3-Methyl-vinylacetyl-CoA
PRODUCT     Crotonoyl-CoA
COMMENT     Also acts on 3-methyl-vinylacetyl-CoA.
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.3
            ExPASy - ENZYME nomenclature database: 5.3.3.3
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.3
            BRENDA, the Enzyme Database: 5.3.3.3
///
ENTRY       EC 5.3.3.4
NAME        Muconolactone delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     5-Oxo-2,5-dihydrofuran-2-acetate delta3-delat2-isomerase
REACTION    2-Oxo-2,5-dihydrofuran-5-acetate =
            2-Oxo-2,3-dihydrofuran-5-acetate
SUBSTRATE   2-Oxo-2,5-dihydrofuran-5-acetate
PRODUCT     2-Oxo-2,3-dihydrofuran-5-acetate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
STRUCTURES  PDB: 1MLI  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.4
            ExPASy - ENZYME nomenclature database: 5.3.3.4
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.4
            BRENDA, the Enzyme Database: 5.3.3.4
            SCOP (Structural Classification of Proteins): 5.3.3.4
///
ENTRY       EC 5.3.3.5
NAME        Cholestenol delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     delta7-Cholestenol delta7-delta8-isomerase
REACTION    5alpha-Cholest-7-en-3beta-ol = 5alpha-Cholest-8-en-3beta-ol
SUBSTRATE   5alpha-Cholest-7-en-3beta-ol
PRODUCT     5alpha-Cholest-8-en-3beta-ol
PATHWAY     PATH: MAP00100  Sterol biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.5
            ExPASy - ENZYME nomenclature database: 5.3.3.5
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.5
            BRENDA, the Enzyme Database: 5.3.3.5
///
ENTRY       EC 5.3.3.6
NAME        Methylitaconate delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Methylitaconate delta2-delta3-isomerase
REACTION    Methylitaconate = Dimethylmaleate
SUBSTRATE   Methylitaconate
PRODUCT     Dimethylmaleate
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.6
            ExPASy - ENZYME nomenclature database: 5.3.3.6
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.6
            BRENDA, the Enzyme Database: 5.3.3.6
///
ENTRY       EC 5.3.3.7
NAME        Aconitate delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Aconitate delta2-delta3-isomerase
REACTION    trans-Aconitate = cis-Aconitate
SUBSTRATE   trans-Aconitate
PRODUCT     cis-Aconitate
COMMENT     cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-
            1,2,3-tricarboxylate. This isomerization could take place either
            in a direct cis-trans iterconversion or by an allelic
            rearrangement; the enzyme has been shown to catalyse the latter
            change.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.7
            ExPASy - ENZYME nomenclature database: 5.3.3.7
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.7
            BRENDA, the Enzyme Database: 5.3.3.7
///
ENTRY       EC 5.3.3.8
NAME        Dodecenoyl-CoA delta-isomerase
            delta3-cis-delta2-trans-Enoyl-CoA isomerase
            Acetylene-allene isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Dodecenoyl-CoA delta3-cis-delta2-trans-isomerase
REACTION    3-cis-Dodecenoyl-CoA = 2-trans-Dodecenoyl-CoA
SUBSTRATE   3-cis-Dodecenoyl-CoA
            3-Acetylenic fatty acyl thioesters
            (+)-2,3-Dienoyl fatty acyl thioesters
PRODUCT     2-trans-Dodecenoyl-CoA
COMMENT     Also catalyses the interconversion of 3-acetylenic fatty acyl
            thioesters and (+)-2,3-dienoyl fatty acyl thioesters, with fatty
            acid chain lengths C6 to C12.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       DME: CG4592 CG4594 CG4598
            HSA: 10455(PECI) 1632(DCI)
DISEASE     MIM: 261515  Enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A
                         dehydrogenase
            MIM: 600305  Dodecenoyl-Coenzyme A delta isomerase (3,2
                         trans-enoyl-Coenzyme A
MOTIF       PS: PS00067  [DNE]-x(2)-[GA]-F-[LIVMFY]-x-[NT]-R-x(3)-[PA]-
                         [LIVMFY](2)-x(5)-[LIVMFYCT]-[LIVMFY]-x(2)-[GV]
            PS: PS00166  [LIVM]-[STA]-x-[LIVM]-[DENQRHSTA]-G-x(3)-[AG](3)-x(4)-
                         [LIVMST]-x-[CSTA]-[DQHP]-[LIVMFY]
            PS: PS00342  [STAGCN]-[RKH]-[LIVMAFY]>
STRUCTURES  PDB: 1HNU  1HNO  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.8
            ExPASy - ENZYME nomenclature database: 5.3.3.8
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.8
            BRENDA, the Enzyme Database: 5.3.3.8
///
ENTRY       EC 5.3.3.9
NAME        Prostaglandin-A1 delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate
            $ delta10-delta11-isomerase
REACTION    (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate =
            (13E)-(15S)-15-Hydroxy-9-oxoprosta-11,13-dienoate
SUBSTRATE   (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate
PRODUCT     (13E)-(15S)-15-Hydroxy-9-oxoprosta-11,13-dienoate
COMMENT     Interconverts prostaglandin A1 and prostaglandin C1.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.9
            ExPASy - ENZYME nomenclature database: 5.3.3.9
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.9
            BRENDA, the Enzyme Database: 5.3.3.9
///
ENTRY       EC 5.3.3.10
NAME        5-Carboxymethyl-2-hydroxymuconate delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     5-Carboxymethyl-2-hydroxymuconate delta2,delta4-2-oxo,
            $delta3-isomerase
REACTION    5-Carboxymethyl-2-hydroxymuconate =
            5-Carboxy-2-oxohept-3-enedioate
SUBSTRATE   5-Carboxymethyl-2-hydroxymuconate
PRODUCT     5-Carboxy-2-oxohept-3-enedioate
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
GENES       YPE: YPO1765(hpaF)
            PMU: PM1532(hpaF)
            VCH: VC2669
            PAE: PA4125(hpcD)
            DRA: DRA0227
STRUCTURES  PDB: 1I7O  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.10
            ExPASy - ENZYME nomenclature database: 5.3.3.10
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.10
            UM-BBD (Biocatalysis/Biodegradation Database): 5.3.3.10
            BRENDA, the Enzyme Database: 5.3.3.10
///
ENTRY       EC 5.3.3.11
NAME        Isopiperitenone delta-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Isopiperitenone delta8-delta4-isomerase
REACTION    Isopiperitenone = Piperitenone
SUBSTRATE   Isopiperitenone
PRODUCT     Piperitenone
COMMENT     Involved in the biosynthesis of menthol and related monoterpenes
            in peppermint (Mentha peperita) leaves.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.11
            ExPASy - ENZYME nomenclature database: 5.3.3.11
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.11
            BRENDA, the Enzyme Database: 5.3.3.11
///
ENTRY       EC 5.3.3.12
NAME        Dopachrome delta-isomerase
            Dopachrome tautomerase
            Dopachrome conversion factor
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing C=C bonds
SYSNAME     Dopachrome delta7-delta2-isomerase
REACTION    L-Dopachrome = 5,6-Dihydroxyindole-2-carboxylate
SUBSTRATE   L-Dopachrome
PRODUCT     5,6-Dihydroxyindole-2-carboxylate
GENES       HSA: 1638(DCT)
DISEASE     MIM: 191275  Dopachrome tautomerase (dopachrome delta-isomerase;
                         tyrosinase-related
MOTIF       PS: PS00497  H-x(4,5)-F-[LIVMFTP]-x-[FW]-H-R-x(2)-[LVM]-x(3)-E
            PS: PS00498  D-P-x-F-[LIVMFYW]-x(2)-H-x(3)-D
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.3.12
            ExPASy - ENZYME nomenclature database: 5.3.3.12
            WIT (What Is There) Metabolic Reconstruction: 5.3.3.12
            BRENDA, the Enzyme Database: 5.3.3.12
///
ENTRY       EC 5.3.4.1
NAME        Protein disulfide-isomerase
            S-S rearrangase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Transposing S-S bonds
SYSNAME     Protein disulfide-isomerase
REACTION    Catalyses the rearrangement of -S-S- bonds in proteins
SUBSTRATE   Protein Cys-Cys
PRODUCT     Protein Cys-Cys
COMMENT     Needs reducing agents or partly-reduced enzyme; the reaction
            depends on sulfhydryl-disulfide interchange.
GENES       ECO: b2893(dsbC)
            ECE: Z4231(dsbC)
            AAE: aq_1740 aq_1811(trxA2)
            MTH: MTH1745
            SCE: YCL043C(PDI1) YDR518W(EUG1) YIL005W YOR288C(MPD1)
            SPO: SPAC17H9.14C(spac17h9.14c) SPAC1F5.02(spac1f5.02)
            CEL: B0403.4 C07A12.4 C14B9.2 H06O01.1
            DME: CG5809(BG:DS09218.4) CG6988(Pdi) CG8983 CG9302
            MMU: 97464(P4hb)
            HSA: 10130 10954(PDIR) 11008(PDI) 2923(GRP58) 5034(P4HB)
                 9601(ERP70)
DISEASE     MIM: 176790  Procollagen-proline, 2-oxoglutarate-4-dioxygenase,
                         beta polypeptide;
MOTIF       PS: PS00014  [KRHQSA]-[DENQ]-E-L>
            PS: PS00194  [LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-
                         C-[GATPLVE]-[PHYWSTA]-C-x(6)-[LIVMFYWT]
STRUCTURES  PDB: 1BJX  1EEJ  1MEK  2BJX  
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.4.1
            ExPASy - ENZYME nomenclature database: 5.3.4.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.4.1
            BRENDA, the Enzyme Database: 5.3.4.1
            SCOP (Structural Classification of Proteins): 5.3.4.1
///
ENTRY       EC 5.3.99.1
NAME        Deleted entry
            Hydroperoxide isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
COMMENT     Deleted entry. Reaction due to combined action of EC 4.2.1.92
            and 5.3.99.6.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.1
            ExPASy - ENZYME nomenclature database: 5.3.99.1
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.1
            BRENDA, the Enzyme Database: 5.3.99.1
///
ENTRY       EC 5.3.99.2
NAME        Prostaglandin-D synthase
            Prostaglandin-H2 D-isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (5,13)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-
            dienoate D-isomerase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate =
            (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate
            Glutathione
PRODUCT     (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate
COMMENT     Brings about the opening of the epidioxy bridge. Some enzymes
            require glutathione.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 99261(Ptgds)
            HSA: 27306(PGDS) 5730(PTGDS)
DISEASE     MIM: 176803  Prostaglandin D2 synthase (21kD, brain)
MOTIF       PS: PS00213  [DENG]-x-[DENQGSTARK]-x(0,2)-[DENQARK]-[LIVFY]-{CP}-G-
                         {C}-W-[FYWLRH]-x-[LIVMTA]
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.2
            ExPASy - ENZYME nomenclature database: 5.3.99.2
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.2
            BRENDA, the Enzyme Database: 5.3.99.2
///
ENTRY       EC 5.3.99.3
NAME        Prostaglandin-E synthase
            Prostaglandin-H2 E-isomerase
            Endoperoxide isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate E-isomerase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate =
            (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate
PRODUCT     (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
COFACTOR    Glutathione
COMMENT     Brings about the opening of the epidioxy bridge. Requires
            glutathione.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.3
            ExPASy - ENZYME nomenclature database: 5.3.99.3
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.3
            BRENDA, the Enzyme Database: 5.3.99.3
///
ENTRY       EC 5.3.99.4
NAME        Prostaglandin-I synthase
            Prostacyclin synthase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate 6-isomerase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate =
            (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-
            $5,13-dienoate
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate
PRODUCT     (5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-
            $5,13-dienoate
COFACTOR    Heme
COMMENT     Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
            A heme-thiol protein.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       HSA: 5740(PTGIS)
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.4
            ExPASy - ENZYME nomenclature database: 5.3.99.4
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.4
            BRENDA, the Enzyme Database: 5.3.99.4
///
ENTRY       EC 5.3.99.5
NAME        Thromboxane-A synthase
            Thromboxane synthase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-
            thromboxane-A2-isomerase
REACTION    (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate =
            (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-
            $dienoate
SUBSTRATE   (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-
            $5,13-dienoate
            Prostaglandin H2
PRODUCT     (5Z,13E)-(15S)-9alpha,11alpha-Epoxy-15-hydroxythromboxa-5,13-
            $dienoate
            Thromboxane A2
COFACTOR    Heme
COMMENT     Converts prostaglandin H2 into thromboxane A2.
            A heme-thiolate protein.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
GENES       MMU: 98497(Tbxas1)
            HSA: 6916(TBXAS1)
DISEASE     MIM: 274180  Thromboxane A synthase 1, platelet
MOTIF       PS: PS00086  [FW]-[SGNH]-x-[GD]-x-[RKHPT]-x-C-[LIVMFAP]-[GAD]
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.5
            ExPASy - ENZYME nomenclature database: 5.3.99.5
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.5
            BRENDA, the Enzyme Database: 5.3.99.5
///
ENTRY       EC 5.3.99.6
NAME        Allene-oxide cyclase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     (9Z)-(13S)-12,13-Epoxyoctadeca-9,11,15-trienoate isomerase
REACTION    (9Z)-(13S)-12,13-Epoxyoctadeca-9,11,15-trienoate =
            (15Z)-12-Oxophyto-10,15-dienoate
SUBSTRATE   (9Z)-(13S)-12,13-Epoxyoctadeca-9,11,15-trienoate
PRODUCT     (15Z)-12-Oxophyto-10,15-dienoate
COMMENT     Allene oxides formed by the action of EC 4.2.1.92 are converted
            into cyclopentenone deirvatives.
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.6
            ExPASy - ENZYME nomenclature database: 5.3.99.6
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.6
            BRENDA, the Enzyme Database: 5.3.99.6
///
ENTRY       EC 5.3.99.7
NAME        Styrene-oxide isomerase
CLASS       Isomerases
            Intramolecular oxidoreductases
            Other intramolecular oxidoreductases
SYSNAME     Styrene-oxide isomerase
REACTION    Styrene oxide = Phenylacetaldehyde
SUBSTRATE   Styrene oxide
PRODUCT     Phenylacetaldehyde
COMMENT     Highly specific.
PATHWAY     PATH: MAP00643  Styrene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.3.99.7
            ExPASy - ENZYME nomenclature database: 5.3.99.7
            WIT (What Is There) Metabolic Reconstruction: 5.3.99.7
            UM-BBD (Biocatalysis/Biodegradation Database): 5.3.99.7
            BRENDA, the Enzyme Database: 5.3.99.7
///
ENTRY       EC 5.4.1.1
NAME        Lysolecithin acylmutase
            Lysolecithin migratase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring acyl groups
SYSNAME     Lysolecithin 2,3-acylmutase
REACTION    2-Lysolecithin = 3-Lysolecithin
SUBSTRATE   2-Lysolecithin
PRODUCT     3-Lysolecithin
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.1.1
            ExPASy - ENZYME nomenclature database: 5.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.4.1.1
            BRENDA, the Enzyme Database: 5.4.1.1
///
ENTRY       EC 5.4.1.2
NAME        Precorrin-8X methylmutase
            Precorrin isomerase
            Hydrogenobyrinic acid-binding protein
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring acyl groups
REACTION    Precorrin 8X = Hydrogenobyrinate
SUBSTRATE   Precorrin 8X
PRODUCT     Hydrogenobyrinate
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       PAE: PA2905(cobH)
            MLO: mlr1379
            SME: SMc03192(cobH)
            CAC: CAC1376(cbiC/cobH)
            MTU: Rv2065(cobH)
            MTC: MT2125
            SYN: sll0916(cbiC)
            MJA: MJ0930(cbiC)
            MTH: MTH227
            AFU: AF0724(cbiH)
            HAL: VNG1567G(cbiC)
            TAC: Ta0654
            TVO: TVG0974537
            SSO: SSO2308(cbiC)
STRUCTURES  PDB: 1F2V  1I1H  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.1.2
            ExPASy - ENZYME nomenclature database: 5.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.4.1.2
///
ENTRY       EC 5.4.2.1
NAME        Phosphoglycerate mutase
            Phosphoglycerate phosphomutase
            Phosphoglyceromutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     D-Phosphoglycerate 2,3-phosphomutase
REACTION    2-Phospho-D-glycerate = 3-Phospho-D-glycerate;
            3-Phospho-D-glyceroyl phosphate = 2,3-Bisphospho-D-glycerate
SUBSTRATE   2-Phospho-D-glycerate
            3-Phospho-D-glyceroyl phosphate
PRODUCT     3-Phospho-D-glycerate
            2,3-Bisphospho-D-glycerate
COMMENT     The enzymes from mammals and from yeast are phosphorylated
            by (2R)-2,3-bisphosphoglycerate, which is also an intermediate
            (see introduction to section 5.4.2). With the rabbit muscle
            enzyme, dissociation of bisphosphate from the enzyme is much
            slower than the overall isomerization. These enzymes also
            catalyse, slowly, the reactions of EC 5.4.2.4; they were
            formerly listed as EC 2.7.5.3. Enzymes from wheat, rice, insects
            and some fungi, however, have maximum activity in the absence of
            2,3-bisphosphoglycerate, and were formerly listed under the
            present number as phosphoglycerate phosphomutase.
            (EC 5.4.2.4 Bisphosphoglycerate mutase)
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       ECO: b0755(gpmA) b3612(yibO) b4395(gpmB)
            ECE: Z0925(gpmA) Z5039(yibO) Z5997(gpmB)
            ECS: ECs0783 ECs4490 ECs5353
            YPE: YPO0064 YPO0455(gpmB) YPO1133(gpmA)
            HIN: HI0757(gpmA)
            PMU: PM1506(gpmA)
            XFA: XF1893
            VCH: VC0336
            PAE: PA5131(pgm)
            BUC: BU304(gpmA)
            NME: NMB1604
            NMA: NMA1801(gpm)
            HPY: HP0974(pgm)
            HPJ: jhp0908
            CJE: Cj0434(pgm)
            MLO: mlr0406 mlr4643
            SME: SMc02838(gpmA)
            CCR: CC1351 CC2261
            BSU: BG10898(pgm) BG13062(yhfR)
            BHA: BH3557(pgm)
            SAU: SA0361 SA0730(pgm) SA2204
            SAV: SAV0762(pgm) SAV2400
            LLA: L0011(pmg) L174407(yjhF)
            SPY: SPy1429(gpmA) SPy1766
            SPN: SP0240 SP0984 SP1655
            SPR: spr0219(gpmB) spr0887(gpmB) spr1499(gpmA)
            CAC: CAC0712(pgm) CAC2741(gpmA) CAC2755 CAC3021
            MGE: MG430(pgm)
            MPN: C12_orf508(pgm)
            MPU: MYPU_4590(pgm)
            UUR: UU182(pgm)
            MTU: Rv0489(gpm) Rv2419c
            MTC: MT0508 MT2492
            MLE: ML1452 ML2441(gpm)
            CTR: CT722
            CMU: TC0095
            CPN: CPn0863
            CPA: CP1006
            CPJ: pgmA
            BBU: BB0658(gpmA)
            TPA: TP0168
            SYN: slr1124(gpmB) slr1945(yibO)
            DRA: DR0278 DR1097 DR1393
            AAE: aq_1744(gpmA) aq_1990(pgmA)
            TMA: TM1374
            HAL: VNG1887G(gpm)
            SCE: YDL021W(GPM2) YKL152C(GPM1) YOL056W(GPM3)
            SPO: GPM1(gpm1)
            CEL: F57B10.3
            DME: CG1721(Pglym78) CG17645 CG17645_1 CG7059
            MMU: 97552(Pgam1)
            HSA: 5223(PGAM1) 5224(PGAM2) 669(BPGM)
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
STRUCTURES  PDB: 1BQ3  1BQ4  1E58  1EJJ  1EQJ  1FZT  1QHF  4PGM  5PGM  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.1
            ExPASy - ENZYME nomenclature database: 5.4.2.1
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.1
            BRENDA, the Enzyme Database: 5.4.2.1
            SCOP (Structural Classification of Proteins): 5.4.2.1
///
ENTRY       EC 5.4.2.2
NAME        Phosphoglucomutase
            Glucose phosphomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     alpha-D-Glucose 1,6-phosphomutase
REACTION    alpha-D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate;
            alpha-D-Hexose 1-phosphate = alpha-D-Hexose 6-phosphate;
            alpha-D-Ribose 1-phosphate = alpha-D-Ribose 5-phosphate
SUBSTRATE   alpha-D-Glucose 1-phosphate
            alpha-D-Hexose 1-phosphate
            alpha-D-Ribose 1-phosphate
PRODUCT     alpha-D-Glucose 6-phosphate
            alpha-D-Hexose 6-phosphate
            alpha-D-Ribose 5-phosphate
COFACTOR    alpha-D-Glucose 1,6-bisphosphate
COMMENT     Maximum activity is only obtained in the presence of alpha-D-
            glucose 1,6-bisphosphate. This bisphosphate is an intermediate
            in the reaction, being formed by transfer of a phosphate residue
            from the enzyme to the substrate, but the dissociation of
            bisphosphate from the enzyme complex is much slower than the
            overall isomerization. The enzyme also, more slowly, catalyses
            the interconversion of 1-phosphate and 6-phosphate isomers of
            many other alpha-D-hexoses, and the interconversion of alpha-D-
            ribose 1-phosphate and 5-phosphate. Formerly EC 2.7.5.1.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00052  Galactose metabolism
            PATH: MAP00500  Starch and sucrose metabolism
            PATH: MAP00521  Streptomycin biosynthesis
            PATH: MAP00522  Erythromycin biosynthesis
            PATH: MAP00530  Aminosugars metabolism
GENES       ECO: b0688(pgm) b3176(glmM)
            ECE: Z0837(pgm)
            ECS: ECs0719
            YPE: YPO2686(pgm)
            VCH: VC2095
            NME: NMB0790
            NMA: NMA1001(pgm)
            MLO: mll3879 mlr7590
            SME: SMb21081(manB) SMc03925(pgm)
            ATU: AGR_L_1564
            CCR: CC0085 CC0117
            BSU: BG12704(glmM)
            BHA: BH0267
            SAU: SA1965(glmM(femD))
            SAV: SAV2148(glmM)
            LLA: L35068(femD)
            SPY: SPy1038
            SPN: SP1559
            CAC: CAC0484
            MTU: Rv3068c(pgmA)
            MTC: MT3153
            CTR: CT815
            CMU: TC0202
            CPN: CPn0967
            CPA: CP0893
            CPJ: pgm
            BBU: BB0004(femD)
            TPA: TP0413
            SYN: sll0726(pgm)
            SCE: YKL127W(PGM1) YMR105C(PGM2)
            SPO: SPBC32F12.10(spbc32f12.10)
            ATH: At1g23190(T26J12.5) At1g70730(F5A18.9)
            CEL: R05F9.6
            DME: CG5165
            MMU: 97564(Pgm1) 97565(Pgm2)
            HSA: 5236(PGM1) 5237(PGM2) 5238(PGM3)
DISEASE     MIM: 171900  Phosphoglucomutase-1
MOTIF       PS: PS00710  [GSA]-[LIVMF]-x-[LIVM]-[ST]-[PGA]-S-H-[NIC]-P
STRUCTURES  PDB: 1JDY  1LXT  1VKL  3PMG  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.2
            ExPASy - ENZYME nomenclature database: 5.4.2.2
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.2
            BRENDA, the Enzyme Database: 5.4.2.2
            SCOP (Structural Classification of Proteins): 5.4.2.2
///
ENTRY       EC 5.4.2.3
NAME        Phosphoacetylglucosamine mutase
            Acetylglucosamine phosphomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     N-Acetyl-D-glucosamine 1,6-phosphomutase
REACTION    N-Acetyl-D-glucosamine 1-phosphate =
            N-Acetyl-D-glucosamine 6-phosphate
SUBSTRATE   N-Acetyl-D-glucosamine 1-phosphate
PRODUCT     N-Acetyl-D-glucosamine 6-phosphate
EFFECTOR    N-Acetyl-D-glucosamine 1,6-bisphosphate
COMMENT     The enzyme is activated by N-acetyl-D-glucosamine
            1,6-bisphosphate.  Formerly EC 2.7.5.2.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
GENES       SPR: spr1417(glmM)
            SCE: YEL058W(PCM1)
            SPO: SPAC13C5.05C(spac13c5.05c)
            CEL: F21D5.1
            HSA: 26089(AGM1)
MOTIF       PS: PS00710  [GSA]-[LIVMF]-x-[LIVM]-[ST]-[PGA]-S-H-[NIC]-P
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.3
            ExPASy - ENZYME nomenclature database: 5.4.2.3
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.3
            BRENDA, the Enzyme Database: 5.4.2.3
///
ENTRY       EC 5.4.2.4
NAME        Bisphosphoglycerate mutase
            Diphosphoglycerate mutase
            Glycerate phosphomutase
            Bisphosphoglycerate synthase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     3-Phospho-D-glycerate 1,2-phosphomutase
REACTION    3-Phospho-D-glyceroyl phosphate = 2,3-Bisphospho-D-glycerate;
            2,3-Bisphospho-D-glycerate + H2O = 3-Phospho-D-glycerate +
            Orthophosphate;
            2-Phospho-D-glycerate = 3-Phospho-D-glycerate
SUBSTRATE   3-Phospho-D-glyceroyl phosphate
            2,3-Bisphospho-D-glycerate
            H2O
            2-Phospho-D-glycerate
PRODUCT     2,3-Bisphospho-D-glycerate
            3-Phospho-D-glycerate
            Orthophosphate
COMMENT     In the direction shown, this enzyme is phosphorylated by
            3-phosphoglyceroyl phosphate to give phosphoenzyme and
            3-phosphoglycerate. The latter is rephosphorylated by the enzyme
            to yield 2,3-bisphosphoglycerate, but this reaction is slowed by
            dissociation of 3-phosphoglycerate from the enzyme, which is
            therefore more active in the persence of added 3-phosphoglycerate.
            This enzyme also catalyses, slowly, the reactions of EC 3.1.3.13
            and 5.4.2.1.
            Formerly EC 2.7.5.4.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
GENES       HSA: 5223(PGAM1) 5224(PGAM2) 669(BPGM)
DISEASE     MIM: 172250  Phosphoglycerate mutase A, nonmuscle form
            MIM: 222800  2,3-bisphosphoglycerate mutase
            MIM: 261670  Phosphoglycerate mutase, muscle form
MOTIF       PS: PS00175  [LIVM]-x-R-H-G-[EQ]-x(3)-N
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.4
            ExPASy - ENZYME nomenclature database: 5.4.2.4
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.4
            BRENDA, the Enzyme Database: 5.4.2.4
///
ENTRY       EC 5.4.2.5
NAME        Phosphoglucomutase (glucose-cofactor)
            Glucose phosphomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     alpha-D-Glucose 1,6-phosphomutase (glucose-cofactor)
REACTION    alpha-D-Glucose 1-phosphate = alpha-D-Glucose 6-phosphate
SUBSTRATE   alpha-D-Glucose 1-phosphate
PRODUCT     alpha-D-Glucose 6-phosphate
EFFECTOR    D-Glucose
COMMENT     The enzyme is activated by D-glucose, which probably acts as an
            acceptor for a phosphate residue from the substrate, thus being
            istself converted into the product. Formerly EC 2.7.5.5.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.5
            ExPASy - ENZYME nomenclature database: 5.4.2.5
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.5
            BRENDA, the Enzyme Database: 5.4.2.5
///
ENTRY       EC 5.4.2.6
NAME        beta-Phosphoglucomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     beta-D-Glucose 1,6-phosphomutase
REACTION    beta-D-Glucose 1-phosphate = beta-D-Glucose 6-phosphate
SUBSTRATE   beta-D-Glucose 1-phosphate
PRODUCT     beta-D-Glucose 6-phosphate
COMMENT     No cofactor requirement has been demonstrated.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
GENES       ECO: b1317(ycjU)
            ECE: Z2465(ycjU)
            ECS: ECs1896
            NME: NMB0391
            NMA: NMA2093(pgm2) NMA2097(pgm1)
            BSU: BG12422(yvdM)
            BHA: BH3864
            LLA: L0001(pgmB)
            CAC: CAC2614
            MPU: MYPU_6350(pgmB)
            SYN: sll1138
            TMA: TM1254
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.6
            ExPASy - ENZYME nomenclature database: 5.4.2.6
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.6
            BRENDA, the Enzyme Database: 5.4.2.6
///
ENTRY       EC 5.4.2.7
NAME        Phosphopentomutase
            Phosphodeoxyribomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     D-Ribose 1,5-phosphomutase
REACTION    D-Ribose 1-phosphate = D-Ribose 5-phosphate;
            2-Deoxy-D-ribose 1-phosphate = 2-Deoxy-D-ribose 5-phosphate
SUBSTRATE   D-Ribose 1-phosphate
            2-Deoxy-D-ribose 1-phosphate
PRODUCT     D-Ribose 5-phosphate
            2-Deoxy-D-ribose 5-phosphate
COFACTOR    D-Ribose 1,5-bisphosphate
            2-Deoxy-D-ribose 1,5-bisphosphate
            alpha-D-Glucose 1,6-bisphosphate
COMMENT     Also converts 2-deoxy-D-ribose 1-phosphate into 5-phosphate.
            D-Ribose 1,5-bisphosphate, 2-deoxy-D-ribose 1,5-bisphosphate,
            or alpha-D-glucose 1,6-bisphosphate can act as cofactor. Formerly
            EC 2.7.5.6.
PATHWAY     PATH: MAP00030  Pentose phosphate cycle
            PATH: MAP00230  Purine metabolism
GENES       ECO: b4383(deoB)
            ECE: Z5985(deoB)
            ECS: ECs5342
            YPE: YPO0439(deoB)
            VCH: VC2348
            BUC: BU542(deoB)
            HPY: HP1179(deoB)
            HPJ: jhp1105
            MLO: mll5587
            SME: SMc04119(deoB)
            ATU: AGR_C_219
            BSU: BG11331(drm)
            BHA: BH1530
            SAU: SA0134(drm)
            SAV: SAV0133(drm)
            LLA: L154925(deoB)
            SPY: SPy0890(deoB)
            SPN: SP0829
            SPR: spr0732(deoB)
            CAC: CAC2065(deoB)
            MPU: MYPU_2770(deoB)
            DRA: DR2135
            TMA: TM0167
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.7
            ExPASy - ENZYME nomenclature database: 5.4.2.7
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.7
            BRENDA, the Enzyme Database: 5.4.2.7
///
ENTRY       EC 5.4.2.8
NAME        Phosphomannomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     D-Mannose 1,6-phosphomutase
REACTION    D-Mannose 1-phosphate = D-Mannose 6-phosphate
SUBSTRATE   D-Mannose 1-phosphate
PRODUCT     D-Mannose 6-phosphate
COFACTOR    D-Mannose 1,6-bisphosphate
            D-Glucose 1,6-bisphosphate
COMMENT     D-Mannose 1,6-bisphosphate or D-glucose 1,6-bisphosphate can
            act as cofactor. Formerly EC 2.7.5.7.
PATHWAY     PATH: MAP00051  Fructose and mannose metabolism
GENES       ECO: b2048(manB)
            ECE: Z3194(manB) Z3212(cpsG)
            ECS: ECs2835 ECs2853
            YPE: YPO2479(manB)
            HIN: HI0740
            PMU: PM1074(yhxB)
            XFA: XF0151 XF0260
            VCH: VC0242 VC0611 VCA1041
            PAE: PA5322(algC)
            HPY: HP1275
            HPJ: jhp1196
            CJE: Cj1407c
            RPR: RP509(exoC)
            RCO: RC0657(exoC)
            MLO: mlr5801
            BSU: BG10189(yhxB)
            BHA: BH1106
            SAU: SA2279
            SAV: SAV2475
            SPY: SPy1224(pgmA) SPy1503
            SPN: SP1498
            SPR: spr1351(pgm)
            CAC: CAC2337 CAC2981
            MGE: MG053(manb)
            MPN: D09_orf554(manB)
            UUR: UU530(cpsG)
            MTU: Rv3257c(pmmA) Rv3308(pmmB) Rv3441c(mrsA)
            MTC: MT3355 MT3407 MT3546
            MLE: ML0366(mrsA) ML0706(pmmB) ML0763(pmmA)
            CTR: CT295
            CPN: CPn0056
            CPA: CP0719
            CPJ: mrsA
            BBU: BB0835(cpsG)
            TPA: TP0642
            SYN: sll1496 slr1334
            DRA: DRA0047
            AAE: aq_501(pmu) aq_718(mpg)
            TMA: TM0769
            MJA: MJ0399(manB) MJ1100
            MTH: MTH1584 MTH1590 MTH1758
            AFU: AF0458(pmm)
            HAL: VNG0905G(pmu2) VNG2206G(pmu1) VNG2276G(pmm)
            TAC: Ta0568
            TVO: TVG0612677
            PHO: PH0923 PH1210
            PAB: PAB0819(pmm) PAB1666
            APE: APE0317 APE2433
            SSO: SSO0207(pmM)
            STO: ST0242
            SCE: YFL045C(SEC53) YMR278W
            SPO: PMM1(pmm1) SPCC1840.05C(spcc1840.05c)
            ATH: At2g45790(F4I18.19)
            CEL: F52B11.2 Y43F4B.5
            DME: CG10195 CG10202 CG10688 CG8073
            HSA: 5372(PMM1) 5373(PMM2)
DISEASE     MIM: 601785  Phosphomannomutase 2
            MIM: 601786  Phosphomannomutase 1
MOTIF       PS: PS00710  [GSA]-[LIVMF]-x-[LIVM]-[ST]-[PGA]-S-H-[NIC]-P
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.8
            ExPASy - ENZYME nomenclature database: 5.4.2.8
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.8
            BRENDA, the Enzyme Database: 5.4.2.8
///
ENTRY       EC 5.4.2.9
NAME        Phosphoenolpyruvate mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Phosphotransferases (phosphomutases)
SYSNAME     Phosphoenolpyruvate 2,3-phosphonomutase
REACTION    Phosphoenolpyruvate = 3-Phosphonopyruvate
SUBSTRATE   Phosphoenolpyruvate
PRODUCT     3-Phosphonopyruvate
COMMENT     Involved in the biosynthesis of the C-P bond, although the
            equilibrium greatly favours phosphoenolpyruvate.
PATHWAY     PATH: MAP00440  Aminophosphonate metabolism
GENES       MLO: mlr5882 mlr9115
STRUCTURES  PDB: 1PYM  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.2.9
            ExPASy - ENZYME nomenclature database: 5.4.2.9
            WIT (What Is There) Metabolic Reconstruction: 5.4.2.9
            BRENDA, the Enzyme Database: 5.4.2.9
            SCOP (Structural Classification of Proteins): 5.4.2.9
///
ENTRY       EC 5.4.3.1
NAME        Deleted entry
            Ornithine 4,5-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
COMMENT     Deleted entry. This reaction was due to a mixture of EC 5.1.1.12
            and 5.4.3.5.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.1
            ExPASy - ENZYME nomenclature database: 5.4.3.1
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.1
///
ENTRY       EC 5.4.3.2
NAME        Lysine 2,3-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     L-Lysine 2,3-aminomutase
REACTION    L-Lysine = (3S)-3,6-Diaminohexanoate
SUBSTRATE   L-Lysine
PRODUCT     (3S)-3,6-Diaminohexanoate
COFACTOR    S-Adenosyl-L-methionine
            Pyridoxal phosphate
COMMENT     Activity is stimulated by S-adenosyl-L-methionine and Pyridoxal
            phosphate.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.2
            ExPASy - ENZYME nomenclature database: 5.4.3.2
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.2
            BRENDA, the Enzyme Database: 5.4.3.2
///
ENTRY       EC 5.4.3.3
NAME        beta-Lysine 5,6-aminomutase
            beta-Lysine mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     (3S)-3,6-Diaminohexanoate 5,6-aminomutase
REACTION    (3S)-3,6-Diaminohexanoate = (3S,5S)-3,5-Diaminohexanoate
SUBSTRATE   (3S)-3,6-Diaminohexanoate
PRODUCT     (3S,5S)-3,5-Diaminohexanoate
COFACTOR    Cobamide coenzyme
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.3
            ExPASy - ENZYME nomenclature database: 5.4.3.3
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.3
            BRENDA, the Enzyme Database: 5.4.3.3
///
ENTRY       EC 5.4.3.4
NAME        D-Lysine 5,6-aminomutase
            D-alpha-Lysine mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     D-2,6-Diaminohexanoate 5,6-aminomutase
REACTION    D-Lysine = 2,5-Diaminohexanoate
SUBSTRATE   D-Lysine
PRODUCT     2,5-Diaminohexanoate
            (3S,5S)-3,5-Diaminohexanoate
COFACTOR    Cobamide coenzyme
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.4
            ExPASy - ENZYME nomenclature database: 5.4.3.4
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.4
            BRENDA, the Enzyme Database: 5.4.3.4
///
ENTRY       EC 5.4.3.5
NAME        D-Ornithine 4,5-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     D-Ornithine 4,5-aminomutase
REACTION    D-Ornithine = D-threo-2,4-Diaminopentanoate
SUBSTRATE   D-Ornithine
PRODUCT     D-threo-2,4-Diaminopentanoate
COFACTOR    Pyridoxal phosphate
            Cobamide coenzyme
            Dithiothreitol
COMMENT     A pyridoxal phosphate protein, which requires a cobamide coenzyme
            and dithiothreitol for activity.
PATHWAY     PATH: MAP00472  D-Arginine and D-ornithine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.5
            ExPASy - ENZYME nomenclature database: 5.4.3.5
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.5
            BRENDA, the Enzyme Database: 5.4.3.5
///
ENTRY       EC 5.4.3.6
NAME        Tyrosine 2,3-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     L-Tyrosine 2,3-aminomutase
REACTION    L-Tyrosine = 3-Amino-3-(4-hydroxyphenyl)propanoate
SUBSTRATE   L-Tyrosine
PRODUCT     3-Amino-3-(4-hydroxyphenyl)propanoate
COFACTOR    ATP
COMMENT     Requires ATP.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.6
            ExPASy - ENZYME nomenclature database: 5.4.3.6
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.6
            BRENDA, the Enzyme Database: 5.4.3.6
///
ENTRY       EC 5.4.3.7
NAME        Leucine 2,3-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     (2S)-alpha-Leucine 2,3-aminomutase
REACTION    (2S)-alpha-Leucine = (3R)-beta-Leucine
SUBSTRATE   (2S)-alpha-Leucine
PRODUCT     (3R)-beta-Leucine
COFACTOR    Cobamide coenzyme
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.7
            ExPASy - ENZYME nomenclature database: 5.4.3.7
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.7
            BRENDA, the Enzyme Database: 5.4.3.7
///
ENTRY       EC 5.4.3.8
NAME        Glutamate-1-semialdehyde 2,1-aminomutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring amino groups
SYSNAME     (S)-4-Amino-5-oxopentanoate 4,5-aminomutase
REACTION    (S)-4-Amino-5-oxopentanoate = 5-Aminolevulinate
SUBSTRATE   (S)-4-Amino-5-oxopentanoate
PRODUCT     5-Aminolevulinate
COFACTOR    Pyridoxal phosphate
PATHWAY     PATH: MAP00860  Porphyrin and chlorophyll metabolism
GENES       ECO: b0154(hemL)
            ECE: Z0165(hemL)
            ECS: ECs0158
            YPE: YPO3389(hemL)
            PMU: PM0462(hemL)
            XFA: XF2302
            VCH: VC0626
            PAE: PA3977(hemL) PA4088 PA5523
            NME: NMB1864
            NMA: NMA0592(hemL)
            HPY: HP0306(hemL)
            HPJ: jhp0291
            CJE: Cj0853c(hemL)
            MLO: mll5149
            SME: SMa0956(atrB)
            CCR: CC3139
            BSU: BG10345(hemL) BG11943(gsaB)
            BHA: BH0943(gsaB) BH2941 BH3043(hemL)
            SAU: SA1491(hemL) SA1681(gsaB)
            SAV: SAV1651(hemL) SAV1849(gsaB)
            CAC: CAC0099(hemL)
            MTU: Rv0524(hemL)
            MTC: MT0546
            MLE: ML2414(hemL)
            CTR: CT210
            CMU: TC0482
            CPN: CPn0138
            CPA: CP0634
            CPJ: hemL
            SYN: sll0017(hemL)
            DRA: DR0555
            AAE: aq_816(gsa)
            MJA: MJ0603(hemL)
            MTH: MTH228
            AFU: AF1241(hemL)
            HAL: VNG2326G(hemL)
            TAC: Ta0571
            TVO: TVG0626624
            APE: APE2130 APE2299
            SSO: SSO0182(hemL)
            STO: ST0215
MOTIF       PS: PS00600  [LIVMFYWC](2)-x-D-E-[IVA]-x(2)-G-[LIVMFAGC]-x(0,1)-
                         [RSACLI]-x-[GSAD]-x(12,16)-D-[LIVMFC]-[LIVMFYSTA]-x(2)-
                         [GSA]-K-x(3)-[GSTADNV]-[GSAC]
STRUCTURES  PDB: 2GSA  3GSB  4GSA  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.3.8
            ExPASy - ENZYME nomenclature database: 5.4.3.8
            WIT (What Is There) Metabolic Reconstruction: 5.4.3.8
            BRENDA, the Enzyme Database: 5.4.3.8
            SCOP (Structural Classification of Proteins): 5.4.3.8
///
ENTRY       EC 5.4.99.1
NAME        Methylaspartate mutase
            Glutamate mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     L-threo-3-Methylaspartate carboxy-aminomethylmutase
REACTION    L-threo-3-Methylaspartate = L-Glutamate
SUBSTRATE   L-threo-3-Methylaspartate
PRODUCT     L-Glutamate
COFACTOR    Cobamide coenzyme
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
STRUCTURES  PDB: 1B1A  1BE1  1CB7  1CCW  1ID8  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.1
            ExPASy - ENZYME nomenclature database: 5.4.99.1
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.1
            BRENDA, the Enzyme Database: 5.4.99.1
            SCOP (Structural Classification of Proteins): 5.4.99.1
///
ENTRY       EC 5.4.99.2
NAME        Methylmalonyl-CoA mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     (R)-2-Methyl-3-oxopropanoyl-CoA CoA-carbonylmutase
REACTION    (R)-2-Methyl-3-oxopropanoyl-CoA = Succinyl-CoA
SUBSTRATE   (R)-2-Methyl-3-oxopropanoyl-CoA
PRODUCT     Succinyl-CoA
COFACTOR    Cobamide
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00640  Propanoate metabolism
GENES       ECO: b2917(sbm)
            ECE: Z4254(sbm)
            ECS: ECs3787
            MLO: mll7619 mll7621
            SME: SMb20757(bhbA)
            CCR: CC2373 CC2374
            BHA: BH2955(mutA) BH2956(mutB)
            MTU: Rv1492(mutA) Rv1493(mutB)
            MTC: MT1539 MT1540
            MLE: ML1799(mutB) ML1800(mutA)
            DRA: DR1084 DR1189 DR2032
            AFU: AF2215(mcmA1) AF2219(mcmA2)
            HAL: VNG0481G(mcmA1) VNG0673G(mcmA2)
            TAC: Ta0462 Ta0463
            TVO: TVG0789597 TVG0790006
            PHO: PH0275 PH1306
            PAB: PAB1800(mcmA1) PAB2187(mcmA2)
            APE: APE1686 APE1687
            SSO: SSO2266(mcmA2) SSO2425(mcmA1)
            STO: ST0552
            CEL: ZK1058.1
            MMU: 97239(Mut)
            HSA: 4594(MUT)
DISEASE     MIM: 251000  Methylmalonyl Coenzyme A mutase
MOTIF       PS: PS00544  R-I-A-R-N-[TQ]-x(2)-[LIVMFY](2)-x-[EQH]-E-x(4)-[KRN]-
                         x(2)-D-P-x-[GSA]-G-S
STRUCTURES  PDB: 1E1C  1REQ  2REQ  3REQ  4REQ  5REQ  6REQ  7REQ  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.2
            ExPASy - ENZYME nomenclature database: 5.4.99.2
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.2
            BRENDA, the Enzyme Database: 5.4.99.2
            SCOP (Structural Classification of Proteins): 5.4.99.2
///
ENTRY       EC 5.4.99.3
NAME        2-Acetolactate mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     2-Acetolactate methylmutase
REACTION    2-Acetolactate = 3-Hydroxy-3-methyl-2-oxobutanoate
SUBSTRATE   2-Acetolactate
            2-Aceto-2-hydroxybutanoate
PRODUCT     3-Hydroxy-3-methyl-2-oxobutanoate
            3-Hydroxy-3-methyl-2-oxopentanoate
COFACTOR    Ascorbic acid
COMMENT     Requires ascorbic acid; also converts 2-aceto-2-hydroxybutanoate
            to 3-hydroxy-3-methyl-2-oxopentanoate.
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.3
            ExPASy - ENZYME nomenclature database: 5.4.99.3
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.3
            BRENDA, the Enzyme Database: 5.4.99.3
///
ENTRY       EC 5.4.99.4
NAME        2-Methyleneglutarate mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     2-Methyleneglutarate carboxy-methylenemethylmutase
REACTION    2-Methyleneglutarate = 2-Methylene-3-methylsuccinate
SUBSTRATE   2-Methyleneglutarate
PRODUCT     2-Methylene-3-methylsuccinate
COFACTOR    Cobamide coenzyme
COMMENT     Requires a cobamide coenzyme.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.4
            ExPASy - ENZYME nomenclature database: 5.4.99.4
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.4
            BRENDA, the Enzyme Database: 5.4.99.4
///
ENTRY       EC 5.4.99.5
NAME        Chorismate mutase
            Hydroxyphenylpyruvate synthase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     Chorismate pyruvatemutase
REACTION    Chorismate = Prephenate
SUBSTRATE   Chorismate
PRODUCT     Prephenate
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
GENES       ECO: b2599(pheA) b2600(tyrA)
            ECE: Z3891(pheA) Z3892(tyrA)
            ECS: ECs3462 ECs3463
            YPE: YPO3281(pheA) YPO3285(tyrA)
            HIN: HI1145(pheA) HI1290(tyrA)
            PMU: PM0150(pheA) PM0664(tyrA)
            XFA: XF2325
            VCH: VC0696 VC0705
            PAE: PA3166(pheA)
            BUC: BU392(pheA)
            NME: NMB0446
            NMA: NMA2039(pheA)
            CJE: Cj0316(pheA)
            MLO: mlr5498
            SME: SMc03858(pheAa)
            BSU: BG10286(aroH) BG10375(aroA) BG10913(pheB)
            BHA: BH1214(pheB) BH1658(aroH) BH3242(aroA)
            SAU: SA1469 SA1558 SA1731
            SAV: SAV1630(pheB) SAV1724 SAV1900(pheA)
            LLA: L64445(ywiC)
            SPY: SPy0722
            SPN: SP1296
            CAC: CAC0892 CAC1234(pheB)
            SYN: sll0109(aroH) sll0934(ccmA)
            DRA: DR1001
            AAE: aq_951(pheA)
            TMA: TM0155 TM0343
            MJA: MJ0246
            MTH: MTH804
            AFU: AF0227(pheA)
            HAL: VNG1244C
            APE: APE0562
            SSO: SSO0246(pheA) SSO0304(aroG)
            STO: ST0294
            SCE: YPR060C(ARO7)
            SPO: SPAC16E8.04C(spac16e8.04c) SPBC30D10.16(spbc30d10.16)
MOTIF       PS: PS00857  [FY]-x-[LIVM]-x(2)-[LIVM]-x(5)-[DN]-x(5)-T-R-F-[LIVMW]-
                         x-[LIVM]
            PS: PS00858  [LIVM]-[ST]-[KR]-[LIVM]-E-[ST]-R-P
STRUCTURES  PDB: 1COM  1DBF  1FNJ  1FNK  2CHS  2CHT  2CSM  3CSM  4CSM  5CSM  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.5
            ExPASy - ENZYME nomenclature database: 5.4.99.5
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.5
            BRENDA, the Enzyme Database: 5.4.99.5
            SCOP (Structural Classification of Proteins): 5.4.99.5
///
ENTRY       EC 5.4.99.6
NAME        Isochorismate synthase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     Isochorismate hydroxymutase
REACTION    Chorismate = Isochorismate
SUBSTRATE   Chorismate
PRODUCT     Isochorismate
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b0593(entC) b2265(menF)
            ECE: Z0735(entC) Z3525(menF)
            ECS: ECs0632 ECs3153
            YPE: YPO2528(menF)
            HIN: HI0285(menF)
            PMU: PM0053(menF)
            VCH: VC0773 VC1976
            PAE: PA4231(pchA)
            BSU: BG10682(menF) BG11242(dhbC)
            SAU: SA0895
            SAV: SAV1029(menF)
            LLA: L0168(menF)
            MTU: Rv3215(entC)
            MTC: MT3311
            MLE: ML0808(entC)
            SYN: slr0817(entC)
            HAL: VNG1083G(menF)
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.6
            ExPASy - ENZYME nomenclature database: 5.4.99.6
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.6
            BRENDA, the Enzyme Database: 5.4.99.6
///
ENTRY       EC 5.4.99.7
NAME        Lanosterol synthase
            2,3-Epoxysqualene lanosterol-cyclase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     (S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
REACTION    (S)-2,3-Epoxysqualene = Lanosterol
SUBSTRATE   (S)-2,3-Epoxysqualene
PRODUCT     Lanosterol
INHIBITOR   29-MOS
COMMENT     29-MOS is a suicide inhibitor, in which 20-methyl group of 
            (S)-2,3-Epoxysqualene is replaced to 20-vinyl group. This group 
            alkylates aspartate residue of the enzyme.  Reaction proceeds via 
            protosteryl cation intermediate.
PATHWAY     PATH: MAP00100  Sterol biosynthesis
GENES       SCE: YHR072W(ERG7)
            SPO: ERG7(erg7)
            HSA: 4047(LSS)
DISEASE     MIM: 600909  Lanosterol synthase
MOTIF       PS: PS01074  [DE]-G-S-W-x-G-x-W-[GA]-[LIVM]-x-[FY]-x-Y-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.7
            ExPASy - ENZYME nomenclature database: 5.4.99.7
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.7
            BRENDA, the Enzyme Database: 5.4.99.7
///
ENTRY       EC 5.4.99.8
NAME        Cycloartenol synthase
            2,3-Epoxysqualene cycloartenol-cyclase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     (S)-2,3-Epoxysqualene mutase (cyclizing, cycloartenol-forming)
REACTION    (S)-2,3-Epoxysqualene = Cycloartenol
SUBSTRATE   (S)-2,3-Epoxysqualene
PRODUCT     Cycloartenol
PATHWAY     PATH: MAP00100  Sterol biosynthesis
MOTIF       PS: PS01074  [DE]-G-S-W-x-G-x-W-[GA]-[LIVM]-x-[FY]-x-Y-[GA]
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.8
            ExPASy - ENZYME nomenclature database: 5.4.99.8
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.8
            BRENDA, the Enzyme Database: 5.4.99.8
///
ENTRY       EC 5.4.99.9
NAME        UDPgalactopyranose mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     UDP-D-galactopyranose furanomutase
REACTION    UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose
SUBSTRATE   UDP-D-galactopyranose
PRODUCT     UDP-D-galacto-1,4-furanose
GENES       ECO: b2036(glf)
            CJE: Cj1439c(glf)
            SPR: spr0319(cps2P)
            CAC: CAC2169
            MGE: MG137(glf)
            MPN: A65_orf399(yefE)
            MTU: Rv3809c(glf)
            MTC: MT3916
            MLE: ML0092(glf)
            DRA: DRA0367
            MTH: MTH344
STRUCTURES  PDB: 1I8T  
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.9
            ExPASy - ENZYME nomenclature database: 5.4.99.9
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.9
            BRENDA, the Enzyme Database: 5.4.99.9
///
ENTRY       EC 5.4.99.10
NAME        Deleted entry
            Isomaltulose synthase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
COMMENT     Deleted entry. Now included with EC 5.4.99.11,
            Isomaltulose synthase.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.10
            ExPASy - ENZYME nomenclature database: 5.4.99.10
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.10
            BRENDA, the Enzyme Database: 5.4.99.10
///
ENTRY       EC 5.4.99.11
NAME        Isomaltulose synthase
            Sucrose glucosylmutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     Sucrose glucosylmutase
REACTION    Sucrose = 6-O-alpha-D-Glucopyranosyl-D-fructofuranose
SUBSTRATE   Sucrose
PRODUCT     6-O-alpha-D-Glucopyranosyl-D-fructofuranose
            Isomaltose
COMMENT     The enzyme simultaneously produces isomaltulose
            (6-O-alpha-D-glucopyranosyl-D-fructose) and smaller amounts of
            trehalulose (1-O-alpha-D-glucopyranosyl-beta-D-fructose)
            from sucrose.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.11
            ExPASy - ENZYME nomenclature database: 5.4.99.11
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.11
            BRENDA, the Enzyme Database: 5.4.99.11
///
ENTRY       EC 5.4.99.12
NAME        tRNA-pseudouridine synthase I
            tRNA-uridine isomerase
            tRNA pseudouridylate synthase I
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     tRNA-uridine uracilmutase
REACTION    tRNA uridine = tRNA pseudouridine
SUBSTRATE   tRNA uridine
PRODUCT     tRNA pseudouridine
COMMENT     The uridylate residues at positions 38, 39 and 40 of nearly all
            tRNAs are isomerized to pseudouridine.
GENES       MLO: mll4852
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.12
            ExPASy - ENZYME nomenclature database: 5.4.99.12
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.12
            BRENDA, the Enzyme Database: 5.4.99.12
///
ENTRY       EC 5.4.99.13
NAME        Isobutyryl-CoA mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     2-Methylpropanoyl-CoA CoA-carbonylmutase
REACTION    2-Methylpropanoyl-CoA = Butanoyl-CoA
SUBSTRATE   2-Methylpropanoyl-CoA
PRODUCT     Butanoyl-CoA
COFACTOR    Cobamide coenzyme
COMMENT     Requires cobamide coenzyme.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.13
            ExPASy - ENZYME nomenclature database: 5.4.99.13
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.13
            BRENDA, the Enzyme Database: 5.4.99.13
///
ENTRY       EC 5.4.99.14
NAME        4-Carboxymethyl-4-methylbutenolide mutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
SYSNAME     4-Carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase
REACTION    4-Carboxymethyl-4-methylbut-2-en-1,4-olide =
            4-Carboxymethyl-3-methylbut-2-en-1,4-olide
SUBSTRATE   4-Carboxymethyl-4-methylbut-2-en-1,4-olide
PRODUCT     4-Carboxymethyl-3-methylbut-2-en-1,4-olide
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.14
            ExPASy - ENZYME nomenclature database: 5.4.99.14
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.14
            BRENDA, the Enzyme Database: 5.4.99.14
///
ENTRY       EC 5.4.99.15
NAME        (1,4)-alpha-D-Glucan 1-alpha-D-glucosylmutase
            Malto-oligosyltrehalose synthase
            Maltodextrin alpha-D-glucosyltransferase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
REACTION    (1,4-alpha-D-Glucosyl)n =
            1-alpha-D-{(1,4)-alpha-D-Glucosyl}(n-1)-alpha-D-glucopyranoside
SUBSTRATE   (1,4-alpha-D-Glucosyl)n
PRODUCT     1-alpha-D-{(1,4)-alpha-D-Glucosyl}(n-1)-alpha-D-glucopyranoside
COMMENT     Acts on (1,4)-alpha-D-glucans containing three or more (1,4)-alpha-
            linked D-glucose units.
            Not active towards maltose.
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.15
            ExPASy - ENZYME nomenclature database: 5.4.99.15
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.15
///
ENTRY       EC 5.4.99.16
NAME        Maltose alpha-D-glucosyltransferase
            Trehalose synthase
            Maltose glucosylmutase
CLASS       Isomerases
            Intramolecular transferases (mutases)
            Transferring other groups
REACTION    Maltose = alpha,alpha-Trehalose
SUBSTRATE   Maltose
PRODUCT     alpha,alpha-Trehalose
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.4.99.16
            ExPASy - ENZYME nomenclature database: 5.4.99.16
            WIT (What Is There) Metabolic Reconstruction: 5.4.99.16
///
ENTRY       EC 5.5.1.1
NAME        Muconate cycloisomerase
            Muconate cycloisomerase I
            Muconate lactonizing enzyme
CLASS       Isomerases
            Intramolecular lyases
            These catalyse reactions in which a group can be regarded as
            eliminated from one part of a molecule, leaving a double bond,
            while remaining covalently attached to the molecule.
SYSNAME     2,5-Dihydro-5-oxofuran-2-acetate lyase (decyclizing)
REACTION    2,5-Dihydro-5-oxofuran-2-acetate = cis,cis-Hexadienedioate;
            4-Methylmuconolactone = 3-Methyl-cis,cis-hexadienedioate
SUBSTRATE   2,5-Dihydro-5-oxofuran-2-acetate
            4-Methylmuconolactone
PRODUCT     cis,cis-Hexadienedioate
            3-Methyl-cis,cis-hexadienedioate
            cis,trans-Hexadienedioate
COFACTOR    Manganese
COMMENT     Requires Mn2+. Also acts, (in the reverse reaction), on 3-methyl-
            -cis,cis-hexadienedioate and, very slowly, on cis,trans-
            -hexadienedioate. Not identical with EC 5.5.1.7 or 5.5.1.11.
            Sequence and three-dimensional structure are similarity to
            mandelate racemase (EC 5.1.2.2); Biochemistry, 1990, 29, 9856-
            -9862; Nature, 1990, 347, 692-694. Both enzymes are functionally
            related to abstract the alpha-proton of carboxylic acids.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00624  Xylene degradation
            PATH: MAP00627  1,4-Dichlorobenzene degradation
GENES       SME: SMa1461
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
            PS: PS00909  [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-
                         [LIVM]-E-[DENQ]-P
STRUCTURES  PDB: 1BKH  1F9C  1MUC  2MUC  3MUC  
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.1
            ExPASy - ENZYME nomenclature database: 5.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.1
            UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.1
            BRENDA, the Enzyme Database: 5.5.1.1
            SCOP (Structural Classification of Proteins): 5.5.1.1
///
ENTRY       EC 5.5.1.2
NAME        3-Carboxy-cis,cis-muconate cycloisomerase
CLASS       Isomerases
            Intramolecular lyases
            These catalyse reactions in which a group can be regarded as
            eliminated from one part of a molecule, leaving a double bond,
            while remaining covalently attached to the molecule.
SYSNAME     2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
REACTION    2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate =
            cis,cis-Butadiene-1,2,4-tricarboxylate
SUBSTRATE   2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
PRODUCT     cis,cis-Butadiene-1,2,4-tricarboxylate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
GENES       PAE: PA0230(pcaB)
            MLO: mlr7211
            SME: SMb20575(pcaB)
            CCR: CC2410
            SPO: SPBC8E4.05C(spbc8e4.05c)
MOTIF       PS: PS00163  G-S-x(2)-M-x(2)-K-x-N
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.2
            ExPASy - ENZYME nomenclature database: 5.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.2
            BRENDA, the Enzyme Database: 5.5.1.2
///
ENTRY       EC 5.5.1.3
NAME        Tetrahydroxypteridine cycloisomerase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     Tetrahydroxypteridine lyase (isomerizing)
REACTION    Tetrahydroxypteridine = Xanthine-8-carboxylate
SUBSTRATE   Tetrahydroxypteridine
PRODUCT     Xanthine-8-carboxylate
COFACTOR    NAD+
COMMENT     Requires NAD+.
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.3
            ExPASy - ENZYME nomenclature database: 5.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.3
            BRENDA, the Enzyme Database: 5.5.1.3
///
ENTRY       EC 5.5.1.4
NAME        myo-Inositol-1-phosphate synthase
CLASS       Isomerases
            Intramolecular lyases
            These catalyse reactions in which a group can be regarded as
            eliminated from one part of a molecule, leaving a double bond,
            while remaining covalently attached to the molecule.
SYSNAME     1L-myo-Inositol-1-phosphate lyase (isomerizing)
REACTION    D-Glucose 6-phosphate = 1L-myo-Inositol 1-phosphate
SUBSTRATE   D-Glucose 6-phosphate
PRODUCT     1L-myo-Inositol 1-phosphate
COFACTOR    NAD+
COMMENT     Requires NAD+.
PATHWAY     PATH: MAP00521  Streptomycin biosynthesis
            PATH: MAP00562  Inositol phosphate metabolism
GENES       TMA: TM1419
            AFU: AF1794(ino1)
            APE: APE1517
            SCE: YJL153C(INO1)
            ATH: At4g39800(T19P19.190)
            CEL: VF13D12L.1
            DME: CG11143
            HSA: 51477(ISYNA1)
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.4
            ExPASy - ENZYME nomenclature database: 5.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.4
            BRENDA, the Enzyme Database: 5.5.1.4
///
ENTRY       EC 5.5.1.5
NAME        Carboxy-cis,cis-muconate cyclase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
REACTION    3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate =
            3-Carboxy-cis,cis-muconate
SUBSTRATE   3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
PRODUCT     3-Carboxy-cis,cis-muconate
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.5
            ExPASy - ENZYME nomenclature database: 5.5.1.5
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.5
            BRENDA, the Enzyme Database: 5.5.1.5
///
ENTRY       EC 5.5.1.6
NAME        Chalcone isomerase
CLASS       Isomerases
            Intramolecular lyases
            These catalyse reactions in which a group can be regarded as
            eliminated from one part of a molecule, leaving a double bond,
            while remaining covalently attached to the molecule.
SYSNAME     Flavanone lyase (decyclizing)
REACTION    a Chalcone = a Flavanone
SUBSTRATE   Chalcone
PRODUCT     Flavanone
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
STRUCTURES  PDB: 1EYP  1EYQ  
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.6
            ExPASy - ENZYME nomenclature database: 5.5.1.6
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.6
            BRENDA, the Enzyme Database: 5.5.1.6
            SCOP (Structural Classification of Proteins): 5.5.1.6
///
ENTRY       EC 5.5.1.7
NAME        Chloromuconate cycloisomerase
            Muconate cycloisomerase II
CLASS       Isomerases
            Intramolecular lyases
            These catalyse reactions in which a group can be regarded as
            eliminated from one part of a molecule, leaving a double bond,
            while remaining covalently attached to the molecule.
SYSNAME     2-Chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
REACTION    2-Chloro-2,5-dihydro-5-oxofuran-2-acetate =
            3-Chloro-cis,cis-muconate
SUBSTRATE   2-Chloro-2,5-dihydro-5-oxofuran-2-acetate
PRODUCT     3-Chloro-cis,cis-muconate
            cis-4-Carboxymethylenebut-2-en-4-olide
            2-Chloro-cis,cis-muconate
COFACTOR    Manganese
COMMENT     Requires Mn2+. The product of cycloisomerization of 3-chloro-
            cis,cis-muconate spontaneously eliminates chloride to produce
            cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse
            direction) on 2-chloro-cis,cis-muconate. Not identical with
            EC 5.5.1.1 or 5.5.1.11.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
            PATH: MAP00627  1,4-Dichlorobenzene degradation
GENES       AFU: AF2099(clcB)
MOTIF       PS: PS00908  [AT]-x-[SAGCN]-[SAGC]-[LIVM]-[DEQ]-x-A-[LA]-x-[DE]-
                         [LIA]-x-[GA]-[KRQ]-x(4)-[PSA]-[LIV]-x(2)-L-[LIVMF]-G
            PS: PS00909  [LIVF]-x(2)-D-x-[NH]-x(7)-[ACL]-x(6)-[LIVMF]-x(7)-
                         [LIVM]-E-[DENQ]-P
STRUCTURES  PDB: 1CHR  2CHR  
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.7
            ExPASy - ENZYME nomenclature database: 5.5.1.7
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.7
            UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.7
            BRENDA, the Enzyme Database: 5.5.1.7
            SCOP (Structural Classification of Proteins): 5.5.1.7
///
ENTRY       EC 5.5.1.8
NAME        Geranyl-diphosphate cyclase
            Bornyl pyrophosphate synthase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     (+)-Bornyl-diphosphate lyase (decyclizing)
REACTION    Geranyl diphosphate = (+)-Bornyl-diphosphate
SUBSTRATE   Geranyl diphosphate
PRODUCT     (+)-Bornyl-diphosphate
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.8
            ExPASy - ENZYME nomenclature database: 5.5.1.8
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.8
            BRENDA, the Enzyme Database: 5.5.1.8
///
ENTRY       EC 5.5.1.9
NAME        Cycloeucalenol cycloisomerase
            Cycloeucalenol--obtusifoliol isomerase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     Cycloeucalenol lyase (cyclopropane-decyclizing)
REACTION    Cycloeucalenol = Obtusifoliol
SUBSTRATE   Cycloeucalenol
PRODUCT     Obtusifoliol
COMMENT     Opens the cyclopropane ring of a number of related 4alpha-methyl-
            -9beta-19-cyclosterols, but not those with a 4beta-methyl group,
            with fromation of an 8(9) double bond. Involved in the synthesis
            of plant sterols.
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.9
            ExPASy - ENZYME nomenclature database: 5.5.1.9
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.9
            BRENDA, the Enzyme Database: 5.5.1.9
///
ENTRY       EC 5.5.1.10
NAME        alpha-Pinene-oxide decyclase
            alpha-Pinene oxide lyase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     alpha-Pinene-oxide lyase (decyclizing)
REACTION    alpha-Pinene-oxide = (Z)-2-Methyl-5-isopropylhexa-2,5-dienal
SUBSTRATE   alpha-Pinene-oxide
PRODUCT     (Z)-2-Methyl-5-isopropylhexa-2,5-dienal
COMMENT     Both rings of pinene are cleaved in the reaction.
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.10
            ExPASy - ENZYME nomenclature database: 5.5.1.10
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.10
            UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.10
            BRENDA, the Enzyme Database: 5.5.1.10
///
ENTRY       EC 5.5.1.11
NAME        Dichloromuconate cycloisomerase
CLASS       Isomerases
            Intramolecular lyases
SYSNAME     2,4-Dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
REACTION    2,4-Dichloro-2,5-dihydro-5-oxofuran-2-acetate =
            2,4-Dichloro-cis,cis-muconate
SUBSTRATE   2,4-Dichloro-2,5-dihydro-5-oxofuran-2-acetate
PRODUCT     2,4-Dichloro-cis,cis-muconate
COFACTOR    Manganese
COMMENT     Requires Mn2+. The product of cyclisomerization of dichloro-
            -cis,cis-muconatre spontaneously eliminates chloride to produce
            reverse direction, on cis,cis-muconate and its monochloro-
            -derivatives, but with lower affinity. Not identical with
            EC 5.5.1.1 or 5.5.1.7.
PATHWAY     PATH: MAP00627  1,4-Dichlorobenzene degradation
DBLINKS     IUBMB Enzyme Nomenclature: 5.5.1.11
            ExPASy - ENZYME nomenclature database: 5.5.1.11
            WIT (What Is There) Metabolic Reconstruction: 5.5.1.11
            UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.11
            BRENDA, the Enzyme Database: 5.5.1.11
///
ENTRY       EC 5.99.1.1
NAME        Thiocyanate isomerase
CLASS       Isomerases
            Other isomerases
SYSNAME     Benzyl-thiocyanate isomerase
REACTION    Benzyl isothiocyanate = Benzyl thiocyanate
SUBSTRATE   Benzyl isothiocyanate
PRODUCT     Benzyl thiocyanate
DBLINKS     IUBMB Enzyme Nomenclature: 5.99.1.1
            ExPASy - ENZYME nomenclature database: 5.99.1.1
            WIT (What Is There) Metabolic Reconstruction: 5.99.1.1
            BRENDA, the Enzyme Database: 5.99.1.1
///
ENTRY       EC 5.99.1.2
NAME        DNA topoisomerase
            Type I DNA topoisomerase
            Untwisting enzyme
            Relaxing enzyme
            Nicking-closing enzyme
            Swivelase
            omega-Protein
CLASS       Isomerases
            Other isomerases
SYSNAME     DNA topoisomerase
REACTION    ATP-independent breakage of single-stranded DNA, followed by
            passage and rejoining
SUBSTRATE   Single-stranded DNA
PRODUCT     Single-stranded DNA
INHIBITOR   Camptothecin
COMMENT     These enzymes bring about the conversion of one topological isomer
            of DNA into another, e.g. the relaxation of superhelical turns in
            DNA, the interconversion of simple and knotted rings of single-
            stranded DNA, and the intertwisting of single-stranded rings of
            complementary sequences (cf. EC 5.99.1.3)
            (EC 5.99.1.3 DNA topoisomerase (ATP-hydrolysing))
GENES       ECO: b1274(topA) b1763(topB)
            ECE: Z2536(topA) Z2796(topB)
            ECS: ECs1846 ECs2469
            YPE: YPO2165(topB) YPO2218(topA)
            HIN: HI0444(topB) HI1365(topA)
            PMU: PM0207(topB) PM0615(topA)
            XFA: XF0920 XF1776 XF2059
            VCH: VC1730 VC2043
            PAE: PA3011(topA)
            BUC: BU284(topA)
            NME: NMB0118
            NMA: NMA0156(topA)
            HPY: HP0116(topA) HP0440(topA)
            HPJ: jhp0108 jhp0919 jhp0931
            CJE: Cj1686c(topA)
            RPR: RP326(topA)
            RCO: RC0449(topA)
            MLO: mlr0839
            SME: SMb21445 SMc01364(topA)
            CCR: CC2451
            BSU: BG11007(topA) BG11979(topB)
            BHA: BH2467(topA) BH3387(topB)
            SAU: SA1093 SA2051(topB)
            SAV: SAV1238 SAV2240(topB)
            LLA: L0298(topA)
            SPY: SPy1164(topA)
            SPN: SP1263
            SPR: spr1141(topA)
            CAC: CAC1785(topA) CAC2947(topB) CAC3567(topB)
            MGE: MG122(topA)
            MPN: A65_orf711(topA)
            MPU: MYPU_4710(topA)
            UUR: UU590(topA)
            MTU: Rv3646c(topA)
            MTC: MT3749
            MLE: ML0200(topA)
            CTR: CT643
            CMU: TC0012
            CPN: CPn0769
            CPA: CP1103
            CPJ: topA
            BBU: BB0828(topA)
            TPA: TP0394
            SYN: slr2058(topA)
            DRA: DR1374
            AAE: aq_657(topA)
            TMA: TM0258
            MJA: MJ1652(topA)
            MTH: MTH1624
            AFU: AF1806(topA)
            HAL: VNG0349G(topA)
            TAC: Ta0063
            TVO: TVG0017184
            PHO: PH0622
            PAB: PAB1430(topA)
            APE: APE1794
            SSO: SSO0907(topA)
            STO: ST1216
            SCE: YLR234W(TOP3) YOL006C(TOP1)
            SPO: TOP1(top1) TOP3(top3)
            ATH: At2g32000(F22D22.25) At5g55300(MTE17.1) At5g55310(MTE17.2)
                 At5g63920(MBM17.2)
            CEL: M01E5.5a
            DME: CG3458(Top3beta) CG6146(Top1)
            MMU: 98788(Top1)
            HSA: 7150(TOP1) 7156(TOP3A) 8940(TOP3B)
DISEASE     MIM: 126420  Topoisomerase (DNA) I
MOTIF       PS: PS00176  [DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM]
            PS: PS00396  [EQ]-x-L-Y-[DEQST]-x(3,12)-[LIV]-[ST]-Y-x-R-[ST]-[DEQS]
STRUCTURES  PDB: 1A31  1A35  1A36  1A41  1CY0  1CY1  1CY2  1CY4  1CY6  1CY7  
                 1CY8  1CY9  1CYY  1D6M  1ECL  1EJ9  1I7D  1OIS  1VCC  1YUA  
DBLINKS     IUBMB Enzyme Nomenclature: 5.99.1.2
            ExPASy - ENZYME nomenclature database: 5.99.1.2
            WIT (What Is There) Metabolic Reconstruction: 5.99.1.2
            BRENDA, the Enzyme Database: 5.99.1.2
            SCOP (Structural Classification of Proteins): 5.99.1.2
///
ENTRY       EC 5.99.1.3
NAME        DNA topoisomerase (ATP-hydrolysing)
            Type II DNA topoisomerase
            DNA-gyrase
CLASS       Isomerases
            Other isomerases
SYSNAME     DNA topoisomerase (ATP-hydrolysing)
REACTION    ATP-dependent breakage, passage and rejoining of double-stranded
            DNA
SUBSTRATE   Double-stranded DNA
            ATP
PRODUCT     Double-stranded DNA
            ADP
            Orthophosphate
INHIBITOR   Novobiocin
            GRI22222X
            Coumermycin A1
            Nalidixic acid
            Ciprofloxacin
COMMENT     The enzyme can introduce negative superhelical turns into
            double-stranded circular DNA. One unit has nicking-closing
            activity, and another catalyses super-twisting and hydrolysis of
            ATP (cf. EC 5.99.1.2 DNA topoisomerase).
            Inhibited by two groups of antibiotics, the coumarins and the
            quinolones.  The coumarins (e.g. novobiocin, coumermycin A1)
            act at the B subunit (Proc.Nat.Acad.Sci.U.S.A. 1978, 75,
            4838-4842).  The quinolones (e.g. nalidixic acid, ciprofloxacin)
            act on the A subunit.  GRI22222X and cyclothialidine are a new
            class of inhibitor (Antimicrob.Agents Chemother. 1994, 37,
            2656-2661).
GENES       ECO: b2231(gyrA) b3699(gyrB)
            ECE: Z3484(gyrA) Z5190(gyrB)
            ECS: ECs3114 ECs4634
            YPE: YPO1216(gyrA) YPO4094(gyrB)
            HIN: HI0567(gyrB) HI1264(gyrA)
            PMU: PM0841(gyrA) PM1476(gyrB)
            XFA: XF0005 XF2552
            VCH: VC0015 VC1258
            PAE: PA0004(gyrB) PA3168(gyrA)
            BUC: BU010(gyrB) BU180(gyrA)
            NME: NMB0212 NMB1384
            NMA: NMA0056(gyrB) NMA1599(gyrA)
            HPY: HP0501(gyrB) HP0701(gyrA)
            HPJ: jhp0453 jhp0641
            CJE: Cj0003(gyrB) Cj1027c(gyrA)
            RPR: RP206(gyrA) RP227(gyrB1) RP580(gyrB2)
            RCO: RC0273(gyrA) RC0309(gyrB1) RC0884(gyrB2)
            MLO: mll0732 mll5188 mlr0901
            SME: SMc01231(gyrA) SMc02782(gyrB)
            CCR: CC0160 CC1580
            BSU: BG10070(gyrB) BG10071(gyrA)
            BHA: BH0006(gyrB) BH0007(gyrA)
            SAU: SA0005(gyrB) SA0006(gyrA)
            SAV: SAV0005(gyrB) SAV0006(gyrA)
            LLA: L0282(gyrA) L0283(gyrB)
            SPY: SPy0727(gyrB) SPy1152(gyrA)
            SPN: SP0806 SP1219
            SPR: spr0715(gyrB) spr1099(gyrA)
            CAC: CAC0006(gyrB) CAC0007(gyrA) CAC1627(gyrB) CAC1628(gyrA)
            MGE: MG003(gyrB) MG004(gyrA)
            MPN: K05_orf650(gyrB) K05_orf839o(gyrA)
            MPU: MYPU_1470(gyrA) MYPU_7390(gyrB)
            UUR: UU081(gyrB) UU082(gyrA)
            MTU: Rv0005(gyrB) Rv0006(gyrA)
            MTC: MT0005 MT0006
            MLE: ML0005(gyrB) ML0006(gyrA)
            CTR: CT189 CT190 CT660 CT661
            CMU: TC0031 TC0032 TC0461 TC0462
            CPN: CPn0274 CPn0275 CPn0715 CPn0716
            CPA: CP0030 CP0031 CP0484 CP0485
            CPJ: gyrA_1 gyrA_2 gyrB_1 gyrB_2
            BBU: BB0435(gyrA) BB0436(gyrB)
            TPA: TP0005 TP1006
            SYN: sll1941(gyrA) sll2005(gyrB) slr0417(gyrA)
            DRA: DR0906 DR1913
            AAE: aq_1026(gyrB) aq_1159(topG1) aq_886(topG2) aq_980(gyrA)
            TMA: TM0173 TM0833 TM1084
            MJA: MJ0369(top6A) MJ1028(top6B) MJ1512(rgy)
            MTH: MTH1007 MTH1008
            AFU: AF0465(gyrA) AF0530(gyrB) AF0652(top6B) AF0940(top6A)
                 AF1024(top-RG)
            HAL: VNG0884G(top6A) VNG0885G(top6B) VNG0887G(gyrB) VNG0889G(gyrA)
            TAC: Ta1054 Ta1055
            TVO: TVG0531155 TVG0533545
            PHO: PH0800 PH1563 PH1564
            PAB: PAB0407(top6B) PAB2411(top6A) PAB2423(top-RG)
            APE: APE0703 APE0706 APE1340 APE1376
            SSO: SSO0420(topR-1) SSO0963(topR-2) SSO0968(top6B) SSO0969(top6A)
            STO: ST0374 ST1290 ST1294 ST1295
            SCE: YHL022C(SPO11) YNL088W(TOP2)
            SPO: REC12(rec12) SPBC1A4.03C
            ATH: At1g64020(F22C12.27) At3g13170(MJG19.19) At3g23890(F14O13.32)
            CEL: F31E8.6 F32A11.4 F32A11.5 K12D12.1 R05D3.1 T05E11.4 ZK1127.7
            DME: CG10223(Top2) CG7753(mei-W68)
            MMU: 98790(Top2a)
            HSA: 23626(SPO11) 7153(TOP2A) 7155(TOP2B)
DISEASE     MIM: 126430  Topoisomerase (DNA) II, alpha, 170kD
            MIM: 126431  Topoisomerase (DNA) II, beta, 180kD
MOTIF       PS: PS00177  [LIVMA]-x-E-G-[DN]-S-A-x-[STAG]
            PS: PS00881  [DNEG]-x-[LIVFA]-[LIVMY]-[LVAST]-H-N-[STC]
STRUCTURES  PDB: 1AB4  1AJ6  1BJT  1D3Y  1EI1  
DBLINKS     IUBMB Enzyme Nomenclature: 5.99.1.3
            ExPASy - ENZYME nomenclature database: 5.99.1.3
            WIT (What Is There) Metabolic Reconstruction: 5.99.1.3
            BRENDA, the Enzyme Database: 5.99.1.3
            SCOP (Structural Classification of Proteins): 5.99.1.3
///
ENTRY       EC 6.1.1.1
NAME        Tyrosine--tRNA ligase
            Tyrosyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Tyrosine:tRNA(Tyr) ligase (AMP-forming)
REACTION    ATP + L-Tyrosine + tRNA(Tyr) = AMP + Pyrophosphate +
            L-Tyrosyl-tRNA(Tyr)
SUBSTRATE   ATP
            L-Tyrosine
            tRNA(Tyr)
PRODUCT     AMP
            Pyrophosphate
            L-Tyrosyl-tRNA(Tyr)
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b1637(tyrS)
            ECE: Z2650(tyrS)
            ECS: ECs2346
            YPE: YPO2369(tyrS)
            HIN: HI1610(tyrS)
            PMU: PM0755(tyrS)
            XFA: XF0169
            VCH: VC0465 VC0631
            PAE: PA0668(tyrZ) PA4138(tyrS)
            BUC: BU121(tyrS)
            NME: NMB1835
            NMA: NMA0620(tyrS)
            HPY: HP0774(tyrS)
            HPJ: jhp0711
            CJE: Cj1271c(tyrS)
            RPR: RP556(tyrS)
            RCO: RC0823(tyrS)
            MLO: mll0007
            SME: SMc00526(tyrS)
            CCR: CC1870
            BSU: BG10371(tyrS) BG10555(tyrZ)
            BHA: BH3228(tyrZ)
            SAU: SA1550(tyrS)
            SAV: SAV1715(tyrS)
            LLA: L0359(tyrS)
            SPY: SPy0096(tyrS)
            SPN: SP2100
            SPR: spr1910(tyrS)
            CAC: CAC0637(tyrS) CAC0780(tyrZ)
            MGE: MG455(tyrS)
            MPN: K05_orf399(tyrS)
            MPU: MYPU_4850(tyrS)
            UUR: UU117(tyrS)
            MTU: Rv1689(tyrS)
            MTC: MT1728
            MLE: ML1352(tyrS)
            CTR: CT062
            CMU: TC0332
            CPN: CPn0361
            CPA: CP0397
            CPJ: tyrS
            BBU: BB0370(tyrS)
            TPA: TP0834
            SYN: slr1031(tyrS) ssr1720(tyrS)
            DRA: DR2634
            AAE: aq_1751(tyrS)
            TMA: TM0478
            MJA: MJ0389(tyrS)
            MTH: MTH1767
            AFU: AF0776(tyrS)
            HAL: VNG2237G(tyrS)
            TAC: Ta0512
            TVO: TVG1042450
            PHO: PH1011
            PAB: PAB1728(tyrS)
            APE: APE2074
            SSO: SSO0078(tyrS)
            SCE: YGR185C(TYS1) YPL097W(MSY1)
            SPO: SPCC1672.05C(spcc1672.05c) SPCC576.06C(spcc576.06c)
            CEL: K08F11.4
            DME: CG16912 CG4561
            HSA: 8565(YARS)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1TYA  1TYB  1TYC  1TYD  2TS1  3TS1  4TS1  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.1
            ExPASy - ENZYME nomenclature database: 6.1.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.1
            BRENDA, the Enzyme Database: 6.1.1.1
            SCOP (Structural Classification of Proteins): 6.1.1.1
///
ENTRY       EC 6.1.1.2
NAME        Tryptophan--tRNA ligase
            Tryptophanyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Tryptophan:tRAN(Trp) ligase (AMP-forming)
REACTION    ATP + L-Tryptophan + tRNA(Trp) = AMP + Pyrophosphate +
            L-Tryptophanyl-tRNA(Trp)
SUBSTRATE   ATP
            L-Tryptophan
            tRNA(Trp)
PRODUCT     AMP
            Pyrophosphate
            L-Tryptophanyl-tRNA(Trp)
PATHWAY     PATH: MAP00380  Tryptophan metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b3384(trpS)
            ECE: Z4737(trpS)
            ECS: ECs4226
            YPE: YPO0157(trpS)
            HIN: HI0637(trpS)
            PMU: PM1621(trpS)
            XFA: XF0428
            VCH: VC2623
            PAE: PA4439(trpS)
            BUC: BU536(trpS)
            NME: NMB1471
            NMA: NMA1682(trpS)
            HPY: HP1253(trpS)
            HPJ: jhp1174
            CJE: Cj0388(trpS)
            RPR: RP468(trpS)
            RCO: RC0710(trpS)
            MLO: mll5317
            SME: SMc01121(trpS)
            CCR: CC0064
            BSU: BG10799(trpS)
            BHA: BH2200 BH2870(trpS)
            SAU: SA0855(trpS)
            SAV: SAV0983(trpS)
            LLA: L0358(trpS)
            SPY: SPy2207(trsA)
            SPN: SP2229
            SPR: spr2034(trpS)
            CAC: CAC0626(trpS)
            MGE: MG126(trpS)
            MPN: A65_orf346(trpS)
            MPU: MYPU_7450(trpS)
            UUR: UU175(trpS)
            MTU: Rv3336c(trpS)
            MTC: MT3440
            MLE: ML0686(trpS)
            CTR: CT585
            CMU: TC0874
            CPN: CPn0802
            CPA: CP1069
            CPJ: trpS
            BBU: BB0005(trsA)
            TPA: TP0632
            SYN: slr1884(trpS)
            DRA: DR0558 DR1093
            AAE: aq_992(trpS)
            TMA: TM0492
            MJA: MJ1415(trpS)
            MTH: MTH251
            AFU: AF1694(trpS)
            HAL: VNG2208G(trpS1) VNG2232G(trpS2)
            TAC: Ta1211
            TVO: TVG1316213
            PHO: PH1921
            PAB: PAB1111(trpS)
            APE: APE2461
            SSO: SSO0452(trpS)
            STO: ST0169
            SCE: YDR268W(MSW1) YOL097C(WRS1)
            SPO: SPAC2F7.13C(spac2f7.13c) SPAC3G9.13C(spac3g9.13c)
            ATH: At3g04600(F7O18.7)
            CEL: C34E10.4
            DME: CG7441 CG9735
            HSA: 10352(WARS2) 7453(WARS)
DISEASE     MIM: 191050  Tryptophanyl-tRNA synthetase
            MIM: 604733  Tryptophanyl-tRNA synthetase 2
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
            PS: PS00762  [QY]-G-[DNEA]-x-[LIV]-[KR]-x(2)-K-x(2)-[KRNG]-[AS]-
                         x(4)-[LIV]-[DENK]-x(2)-[IV]-x(2)-L-x(3)-K
STRUCTURES  PDB: 1D2R  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.2
            ExPASy - ENZYME nomenclature database: 6.1.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.2
            BRENDA, the Enzyme Database: 6.1.1.2
            SCOP (Structural Classification of Proteins): 6.1.1.2
///
ENTRY       EC 6.1.1.3
NAME        Threonine--tRNA ligase
            Threonyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Threonine:tRNA(Thr) ligase (AMP-forming)
REACTION    ATP + L-Threonine + tRNA(Thr) = AMP + Pyrophosphate +
            L-Threonyl-tRNA(Thr)
SUBSTRATE   ATP
            L-Threonine
            tRNA(Thr)
PRODUCT     AMP
            Pyrophosphate
            L-Threonyl-tRNA(Thr)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b1719(thrS)
            ECE: Z2748(thrS)
            ECS: ECs2426
            YPE: YPO2433(thrS)
            HIN: HI1367(thrS)
            PMU: PM0593(thrS)
            XFA: XF0736
            VCH: VCA0287
            PAE: PA2744(thrS)
            BUC: BU125(thrS)
            NME: NMB0720
            NMA: NMA0929(thrS)
            HPY: HP0123(thrS)
            HPJ: jhp0113
            CJE: Cj0206(thrS)
            RPR: RP221(thrS)
            RCO: RC0296(thrS)
            MLO: mll0914
            SME: SMc01010(thrS)
            CCR: CC0464
            BSU: BG10362(thrS) BG10421(thrZ)
            BHA: BH3141(thrS)
            SAU: SA1506(thrS)
            SAV: SAV1669(thrS)
            LLA: L0357(thrS)
            SPY: SPy0517(thrS)
            SPN: SP1631
            SPR: spr1472(thrS)
            CAC: CAC2362(thrS)
            MGE: MG375(thrs)
            MPN: G12_orf564(thrS)
            MPU: MYPU_7460(thrS)
            UUR: UU534(thrS)
            MTU: Rv2614c(thrS)
            MTC: MT2689
            MLE: ML0456(thrS)
            CTR: CT581
            CMU: TC0870
            CPN: CPn0806
            CPA: CP1065
            CPJ: thrS
            BBU: BB0720(thrZ)
            TPA: TP0837
            SYN: sll0078(thrS)
            DRA: DR2081
            AAE: aq_1667(thrS)
            TMA: TM0740
            MJA: MJ1197(thrS)
            MTH: MTH1455
            AFU: AF0548(thrS)
            HAL: VNG1835G(thrS)
            TAC: Ta0330
            TVO: TVG1345067
            PHO: PH0699
            PAB: PAB1490(thrS)
            APE: APE0117 APE0809
            SSO: SSO2486(thrS)
            STO: ST0966
            SCE: YIL078W(THS1) YKL194C(MST1)
            SPO: SPAC24C9.09(spac24c9.09) THS1(ths1)
            ATH: At5g26830(F2P16.7)
            CEL: C47D12.6
            DME: CG5353
            HSA: 6897(TARS)
DISEASE     MIM: 187790  Threonyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
STRUCTURES  PDB: 1QF6  1EVK  1EVL  1FYF  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.3
            ExPASy - ENZYME nomenclature database: 6.1.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.3
            BRENDA, the Enzyme Database: 6.1.1.3
            SCOP (Structural Classification of Proteins): 6.1.1.3
///
ENTRY       EC 6.1.1.4
NAME        Leucine--tRNA ligase
            Leucyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Leucine-tRNA(Leu) ligase (AMP-forming)
REACTION    ATP + L-Leucine + tRNA(Leu) = AMP + Pyrophosphate +
            L-Leucyl-tRNA(Leu)
SUBSTRATE   ATP
            L-Leucine
            tRNA(Leu)
PRODUCT     AMP
            Pyrophosphate
            L-Leucyl-tRNA(Leu)
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0642(leuS)
            ECE: Z0789(leuS)
            ECS: ECs0680
            YPE: YPO2610(leuS)
            HIN: HI0921(leuS)
            PMU: PM1214(leuS)
            XFA: XF2176
            VCH: VC0956
            PAE: PA3987(leuS)
            BUC: BU444(leuS)
            NME: NMB1897
            NMA: NMA0559(leuS)
            HPY: HP1547(leuS)
            HPJ: jhp1452
            CJE: Cj1091c(leuS)
            RPR: RP421(leuS)
            RCO: RC0585(leuS)
            MLO: mll4077
            SME: SMc02804(leuS)
            CCR: CC3749
            BSU: BG10676(leuS)
            BHA: BH3281(leuS)
            SAU: SA1579(leuS)
            SAV: SAV1744(leuS)
            LLA: L0352(leuS)
            SPY: SPy0173(leuS)
            SPN: SP0254
            SPR: spr0235(leuS)
            CAC: CAC0646(leuS)
            MGE: MG266(leuS)
            MPN: F11_orf793o(leuS)
            MPU: MYPU_0930(leuS)
            UUR: UU371(leuS)
            MTU: Rv0041(leuS)
            MTC: MT0047
            MLE: ML0032(leuS)
            CTR: CT209
            CMU: TC0481
            CPN: CPn0153
            CPA: CP0618
            CPJ: leuS
            BBU: BB0251(leuS)
            TPA: TP0586
            SYN: sll1074(leuS)
            DRA: DR2174
            AAE: aq_1770(leuS') aq_351(leuS)
            TMA: TM0168
            MJA: MJ0633(leuS)
            MTH: MTH1508
            AFU: AF2421(leuS)
            HAL: VNG2223G(leuS)
            TAC: Ta0777
            TVO: TVG0775903
            PHO: PH0965
            PAB: PAB1782(leuS)
            APE: APE1015
            SSO: SSO0504(leuS-1) SSO0589(leuS-2)
            STO: ST0625
            SCE: YLR382C(NAM2) YPL160W(CDC60)
            SPO: SPAC26F1.13C(spac26f1.13c) SPAC4G8.09(spac4g8.09)
            CEL: R74.1 ZK524.3
            DME: CG3229 CG7479
            HSA: 23395(KIAA0028) 3926(LARS)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.4
            ExPASy - ENZYME nomenclature database: 6.1.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.4
            BRENDA, the Enzyme Database: 6.1.1.4
///
ENTRY       EC 6.1.1.5
NAME        Isoleucine--tRNA ligase
            Isoleucyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Isoleucine:tRNA(Ile) ligase (AMP-forming)
REACTION    ATP + L-Isoleucine + tRNA(Ile) = AMP + Pyrophosphate +
            L-Isoleucyl-tRNA(Ile)
SUBSTRATE   ATP
            L-Isoleucine
            tRNA(Ile)
PRODUCT     AMP
            Pyrophosphate
            L-Isoleucyl-tRNA(Ile)
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0026(ileS)
            ECE: Z0030(ileS)
            ECS: ECs0029
            YPE: YPO0475(ileS)
            HIN: HI0962(ileS)
            PMU: PM1662(ileS)
            XFA: XF2418
            VCH: VC0682
            PAE: PA4560(ileS)
            BUC: BU149(ileS)
            NME: NMB1833
            NMA: NMA0622(ileS)
            HPY: HP1422(ileS)
            HPJ: jhp1317
            CJE: Cj1061c(ileS)
            RPR: RP617(ileS)
            RCO: RC0953(ileS)
            MLO: mlr8250
            SME: SMc00908(ileS)
            CCR: CC0701
            BSU: BG11792(ileS)
            BHA: BH2545(ileS)
            SAU: SA1036(ileS)
            SAV: SAV1181(ileS)
            LLA: L0350(ileS)
            SPY: SPy1513(ileS)
            SPN: SP1659
            SPR: spr1502(ileS)
            CAC: CAC3038(ileS)
            MGE: MG345(ileS)
            MPN: G12_orf861(ileS)
            MPU: MYPU_6670(ileS)
            UUR: UU410(ileS)
            MTU: Rv1536(ileS)
            MTC: MT1587
            MLE: ML1195(ileS)
            CTR: CT019
            CMU: TC0288
            CPN: CPn0109
            CPA: CP0665
            CPJ: ileS
            BBU: BB0833(ileS)
            TPA: TP0452
            SYN: sll1362(ileS)
            DRA: DR1335
            AAE: aq_305(ileS)
            TMA: TM1361
            MJA: MJ0947(ileS)
            MTH: MTH1375(ileS)
            AFU: AF0633(ileS)
            HAL: VNG2190G(ileS)
            TAC: Ta0879
            TVO: TVG0867938
            PHO: PH1065
            PAB: PAB0616(ileS)
            APE: APE0374
            SSO: SSO0722(ileS)
            STO: ST0431
            SCE: YBL076C(ILS1) YPL040C(ISM1)
            SPO: SPBC8D2.06(spbc8d2.06) SPCC18B5.08C(spcc18b5.08c)
            ATH: At5g49030(K19E20.18)
            CEL: C25A1.7a R11A8.6
            DME: CG11471 CG5414
            HSA: 3376(IARS)
DISEASE     MIM: 600709  Isoleucine-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1QU3  1QU2  1FFY  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.5
            ExPASy - ENZYME nomenclature database: 6.1.1.5
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.5
            BRENDA, the Enzyme Database: 6.1.1.5
            SCOP (Structural Classification of Proteins): 6.1.1.5
///
ENTRY       EC 6.1.1.6
NAME        Lysine--tRNA ligase
            Lysyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Lysine:tRNA(Lys) ligase (AMP-forming)
REACTION    ATP + L-Lysine + tRNA(Lys) = AMP + Pyrophosphate +
            L-Lysyl-tRNA(Lys)
SUBSTRATE   ATP
            L-Lysine
            tRNA(Lys)
PRODUCT     AMP
            Pyrophosphate
            L-Lysyl-tRNA(Lys)
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b2890(lysS) b4129(lysU) b4155(yjeA)
            ECE: Z4228(lysS) Z5732(lysU) Z5763(yjeA)
            ECS: ECs3762 ECs5111 ECs5136
            YPE: YPO0362(poxA) YPO0888(lysS)
            HIN: HI0836(genX) HI1211(lysS)
            PMU: PM0189(lysU_1) PM0202(lysU_2)
            XFA: XF1112 XF2555
            VCH: VC0664 VC2655
            PAE: PA3700(lysS)
            BUC: BU437(lysS) BU582(yjeA)
            NME: NMB1425
            NMA: NMA1638(lysS)
            HPY: HP0182(lysS)
            HPJ: jhp0170
            CJE: Cj0401(lysS)
            RPR: RP371(lysS)
            RCO: RC0505(lysS)
            MLO: mll5634 mlr8260
            SME: SMc00356(genX) SMc03173(lysS)
            CCR: CC0084
            BSU: BG10144(lysS)
            BHA: BH0098(lysS)
            SAU: SA0475(lysS)
            SAV: SAV0507(lysS)
            LLA: L0347(lysS)
            SPY: SPy0595(lysS)
            SPN: SP0713
            SPR: spr0626(lysS)
            CAC: CAC3197(lysS)
            MGE: MG136(lysS)
            MPN: A65_orf489(lysS)
            MPU: MYPU_3900(lysS) MYPU_4020(lysS)
            UUR: UU062(lysS)
            MTU: Rv1640c(lysX) Rv3598c(lysS)
            MTC: MT1678 MT3705
            MLE: ML0233(lysS) ML1393(lysX)
            CTR: CT781
            CMU: TC0163
            CPN: CPn0931
            CPA: CP0932
            CPJ: lysS
            BBU: BB0659
            TPA: TP0644 TP1040
            SYN: slr1550(lysS)
            DRA: DR0372
            AAE: aq_1202(lysU) aq_763(genX)
            TMA: TM1705
            MJA: MJ0539(lysS)
            MTH: MTH1542
            AFU: AF1216(lysS)
            HAL: VNG2017G(lysS)
            TAC: Ta1163
            TVO: TVG1282914
            PHO: PH0224
            PAB: PAB0139(lysS)
            APE: APE0161
            SSO: SSO0090(lysS)
            SCE: YDR037W(KRS1) YNL073W(MSK1)
            SPO: SPBC17G9.03C(spbc17g9.03c) SPCC18.08(spcc18.08)
            CEL: T02G5.9
            DME: CG12141
            HSA: 3735(KARS)
DISEASE     MIM: 601421  Lysyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
            PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
STRUCTURES  PDB: 1LYL  1BBU  1BBW  1E1O  1E1T  1E22  1KRT  1KRS  1E24  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.6
            ExPASy - ENZYME nomenclature database: 6.1.1.6
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.6
            BRENDA, the Enzyme Database: 6.1.1.6
            SCOP (Structural Classification of Proteins): 6.1.1.6
///
ENTRY       EC 6.1.1.7
NAME        Alanine--tRNA ligase
            Alanyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Alanine:tRNA(Ala) ligase (AMP-forming)
REACTION    ATP + L-Alanine + tRNA(Ala) = AMP + Pyrophosphate +
            L-Alanyl-tRNA(Ala)
SUBSTRATE   ATP
            L-Alanine
            tRNA(Ala)
PRODUCT     AMP
            Pyrophosphate
            L-Alanyl-tRNA(Ala)
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b2697(alaS)
            ECE: Z3999(alaS)
            ECS: ECs3554
            YPE: YPO3305(alaS)
            HIN: HI0814(alaS)
            PMU: PM1287(alaS)
            XFA: XF0124
            VCH: VC0545
            PAE: PA0903(alaS)
            BUC: BU403(alaS)
            NME: NMB1595
            NMA: NMA1788(alaS)
            HPY: HP1241(alaS)
            HPJ: jhp1162
            CJE: Cj0506(alaS)
            RPR: RP856(alaS)
            RCO: RC1327(alaS)
            MLO: mlr0032
            SME: SMc00475(alaS)
            CCR: CC2529
            BSU: BG12563(alaS)
            BHA: BH1267(alaS)
            SAU: SA1446(alaS)
            SAV: SAV1606(alaS)
            LLA: L0343(alaS)
            SPY: SPy1389(alaS)
            SPN: SP1383
            SPR: spr1240(alaS)
            CAC: CAC1678(alaS)
            MGE: MG292(alaS)
            MPN: A05_orf900(alaS)
            MPU: MYPU_5570(alaS)
            UUR: UU369(alaS)
            MTU: Rv2555c(alaS)
            MTC: MT2632
            MLE: ML0512(alaS)
            CTR: CT749
            CMU: TC0125
            CPN: CPn0892
            CPA: CP0974
            CPJ: alaS
            BBU: BB0220(alaS)
            TPA: TP1017
            SYN: sll0362(alaS)
            DRA: DR2300
            AAE: aq_1293(alaS)
            TMA: TM1396
            MJA: MJ0564(alaS)
            MTH: MTH1683
            AFU: AF2255(alaS)
            HAL: VNG2283G(alaS)
            TAC: Ta0499 Ta0849
            TVO: TVG0850702
            PHO: PH0297 PH1969
            PAB: PAB1245(alaS)
            APE: APE0903 APE2166
            SSO: SSO0341(alaS) SSO0450(alaS-like1)
            STO: ST0167 ST1364
            SCE: YOR335C(ALA1)
            SPO: SPAC23C11.09(spac23c11.09)
            CEL: F28H1.3 W02B12.6
            DME: CG13391(Aats-ala) CG4633(Aats-ala-m)
            HSA: 16(AARS)
DISEASE     MIM: 601065  Alanyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.7
            ExPASy - ENZYME nomenclature database: 6.1.1.7
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.7
            BRENDA, the Enzyme Database: 6.1.1.7
///
ENTRY       EC 6.1.1.8
NAME        Deleted entry
            D-Alanine-sRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
COMMENT     Deleted entry.
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.8
            ExPASy - ENZYME nomenclature database: 6.1.1.8
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.8
///
ENTRY       EC 6.1.1.9
NAME        Valine--tRNA ligase
            Valyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Valine:tRNA(Val) ligase (AMP-forming)
REACTION    ATP + L-Valine + tRNA(Val) = AMP + Pyrophosphate +
            L-Valyl-tRNA(Val)
SUBSTRATE   ATP
            L-Valine
            tRNA(Val)
PRODUCT     AMP
            Pyrophosphate
            L-Valyl-tRNA(Val)
PATHWAY     PATH: MAP00290  Valine, leucine and isoleucine biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b4258(valS)
            ECE: Z5870(valS)
            ECS: ECs5235
            YPE: YPO3443(valS)
            HIN: HI1391(valS)
            PMU: PM0818(valS)
            XFA: XF0134
            VCH: VC2503
            PAE: PA3834(valS)
            BUC: BU366(valS)
            NME: NMB0174
            NMA: NMA0094(valS)
            HPY: HP1153(valS)
            HPJ: jhp1080
            CJE: Cj0775c(valS)
            RPR: RP687(valS)
            RCO: RC1053(valS)
            MLO: mll1104
            SME: SMc02080(valS)
            CCR: CC1320
            BSU: BG10321(valS)
            BHA: BH3038(valS)
            SAU: SA1488(valS)
            SAV: SAV1647(valS)
            LLA: L0351(valS)
            SPY: SPy1568(valS)
            SPN: SP0568
            SPR: spr0492(valS)
            CAC: CAC2399(vals)
            MGE: MG334(valS)
            MPN: P01_orf838(valS)
            MPU: MYPU_2570(valS)
            UUR: UU267(valS)
            MTU: Rv2448c(valS)
            MTC: MT2524
            MLE: ML1472(valS)
            CTR: CT302
            CMU: TC0576
            CPN: CPn0094
            CPA: CP0680
            CPJ: valS
            BBU: BB0738(valS)
            TPA: TP1035(valS)
            SYN: slr0557(valS)
            DRA: DR0148
            AAE: aq_1413(valS)
            TMA: TM1817
            MJA: MJ1007(valS)
            MTH: MTH767
            AFU: AF2224(valS)
            HAL: VNG2547G(valS)
            TAC: Ta0040
            TVO: TVG0034869
            PHO: PH0314
            PAB: PAB1255(valS)
            APE: APE1805
            SSO: SSO0899(valS)
            STO: ST1224
            SCE: YGR094W(VAS1)
            SPO: SPAC4A8.08C(spac4a8.08c) SPBC1709.02C
            CEL: ZC513.4
            DME: CG4062 CG5660
            HSA: 7406(VARS1) 7407(VARS2)
DISEASE     MIM: 192150  Valyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1GAX  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.9
            ExPASy - ENZYME nomenclature database: 6.1.1.9
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.9
            BRENDA, the Enzyme Database: 6.1.1.9
            SCOP (Structural Classification of Proteins): 6.1.1.9
///
ENTRY       EC 6.1.1.10
NAME        Methionine--tRNA ligase
            Methionyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Methione:tRNA(Met) ligase (AMP-forming)
REACTION    ATP + L-Methionine + tRNA(Met) = AMP + Pyrophosphate +
            L-Methionyl-tRNA(Met)
SUBSTRATE   ATP
            L-Methionine
            tRNA(Met)
PRODUCT     AMP
            Pyrophosphate
            L-Methionyl-tRNA(Met)
PATHWAY     PATH: MAP00271  Methionine metabolism
            PATH: MAP00450  Selenoamino acid metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b2114(metG)
            ECE: Z3282(metG)
            ECS: ECs2920
            YPE: YPO1522(metG)
            HIN: HI1276(metG)
            PMU: PM0303(metG)
            XFA: XF0549
            VCH: VC1036
            PAE: PA3482(metG)
            BUC: BU109(metG)
            NME: NMB0030
            NMA: NMA0275(metG)
            HPY: HP0417(metS)
            HPJ: jhp0967
            CJE: Cj0838c(metS)
            RPR: RP683(metS)
            RCO: RC1046(metS)
            MLO: mll0419
            SME: SMc01192(metS)
            CCR: CC1480
            BSU: BG10101(metS)
            BHA: BH0053(metS)
            SAU: SA0448(metS)
            SAV: SAV0477(metS)
            LLA: L0353(metS)
            SPY: SPy0422(metS)
            SPN: SP0788
            SPR: spr0696(metS)
            CAC: CAC2991(metS)
            MGE: MG021(metS)
            MPN: B01_orf512(metS)
            MPU: MYPU_4900(metS)
            UUR: UU197(metS)
            MTU: Rv1007c(metS)
            MTC: MT1036
            MLE: ML0238(metS)
            CTR: CT032
            CMU: TC0301
            CPN: CPn0122
            CPA: CP0651
            CPJ: metG
            BBU: BB0587(metG)
            TPA: TP0798
            SYN: slr0649(metS)
            DRA: DR1433
            AAE: aq_1257(metG) aq_422(metG')
            TMA: TM1085
            MJA: MJ1263(metS)
            MTH: MTH587
            AFU: AF1453(metS)
            HAL: VNG0326G(metS)
            TAC: Ta1162
            TVO: TVG1284612
            PHO: PH0993
            PAB: PAB2364(metS)
            APE: APE0675 APE1129
            SSO: SSO0558(metS) SSO0627(metS-like)
            SCE: YGR171C(MSM1) YGR264C(MES1)
            SPO: SPAC27E2.06C(spac27e2.06c) SPBC17A3.04C
            CEL: F58B3.5
            DME: CG8684
            HSA: 4141(MARS)
DISEASE     MIM: 156560  Methioninyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1QQT  1MED  1MEA  1A8H  1F4L  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.10
            ExPASy - ENZYME nomenclature database: 6.1.1.10
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.10
            BRENDA, the Enzyme Database: 6.1.1.10
            SCOP (Structural Classification of Proteins): 6.1.1.10
///
ENTRY       EC 6.1.1.11
NAME        Serine--tRNA ligase
            Seryl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Serine:tRNA(Ser) ligase (AMP-forming)
REACTION    ATP + L-Serine + tRNA(Ser) = AMP + Pyrophosphate +
            L-Seryl-tRNA(Ser)
SUBSTRATE   ATP
            L-Serine
            tRNA(Ser)
PRODUCT     AMP
            Pyrophosphate
            L-Seryl-tRNA(Ser)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0893(serS)
            ECE: Z1239(serS)
            ECS: ECs0978
            YPE: YPO1379(serS)
            HIN: HI0110(serS)
            PMU: PM0258(serS)
            XFA: XF2286
            VCH: VC1110
            PAE: PA2612(serS)
            BUC: BU313(serS)
            NME: NMB1684
            NMA: NMA1943(serS)
            HPY: HP1480(serS)
            HPJ: jhp1373
            CJE: Cj0389(serS)
            RPR: RP783(serS)
            RCO: RC1216(serS)
            MLO: mll1081
            SME: SMc02064(serS)
            CCR: CC1999
            BSU: BG10077(serS)
            BHA: BH0024(serS)
            SAU: SA0009(serS)
            SAV: SAV0009(serS)
            LLA: L150515(serS)
            SPY: SPy1742(serS)
            SPN: SP0411
            SPR: spr0372(serS)
            CAC: CAC0017(serS) CAC0021(serS)
            MGE: MG005(serS)
            MPN: D12_orf420(serS)
            MPU: MYPU_0340(serS)
            UUR: UU106(serS)
            MTU: Rv3834c(serS)
            MTC: MT3942
            MLE: ML0082(serS)
            CTR: CT729
            CMU: TC0102
            CPN: CPn0870
            CPA: CP0999
            CPJ: serS
            BBU: BB0226(serS)
            TPA: TP0647
            SYN: slr1703(serS)
            DRA: DR1276
            AAE: aq_298(serS)
            TMA: TM1379
            MJA: MJ1077(serS)
            MTH: MTH1122
            AFU: AF2035(serS)
            HAL: VNG2072G(serS)
            TAC: Ta0468
            TVO: TVG1039759
            PHO: PH0710
            PAB: PAB0881(serS)
            APE: APE1976
            SSO: SSO0602(serS)
            SCE: YDR023W(SES1) YHR011W
            SPO: SPAC25B8.06C(spac25b8.06c) SPAC29A4.15(spac29a4.15)
            ATH: At5g27470(F21A20.180)
            CEL: C47E12.1 W03B1.4
            DME: CG17259 CG4938(Aats-ser)
            MMU: 102809(Sars)
            HSA: 6301(SARS)
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
STRUCTURES  PDB: 1SRY  1SET  1SES  1SER  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.11
            ExPASy - ENZYME nomenclature database: 6.1.1.11
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.11
            BRENDA, the Enzyme Database: 6.1.1.11
            SCOP (Structural Classification of Proteins): 6.1.1.11
///
ENTRY       EC 6.1.1.12
NAME        Aspartate--tRNA ligase
            Aspartyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Aspartate:tRNA(Asp) ligase (AMP-forming)
REACTION    ATP + L-Aspartate + tRNA(Asp) = AMP + Pyrophosphate +
            L-Aspartyl-tRNA(Asp)
SUBSTRATE   ATP
            L-Aspartate
            tRNA(Asp)
PRODUCT     AMP
            Pyrophosphate
            L-Aspartyl-tRNA(Asp)
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b1866(aspS)
            ECE: Z2919(aspS)
            ECS: ECs2576
            YPE: YPO2053(aspS)
            HIN: HI0317(aspS)
            PMU: PM0983(aspS)
            XFA: XF1856
            VCH: VC1166
            PAE: PA0963(aspS)
            BUC: BU316(aspS)
            NME: NMB0466
            NMA: NMA2019(aspS)
            HPY: HP0617(aspS)
            HPJ: jhp0560
            CJE: Cj0640c(aspS)
            RPR: RP145(aspS)
            RCO: RC0187(aspS)
            MLO: mlr8358
            SME: SMc01756(aspS)
            CCR: CC1892
            BSU: BG12572(aspS)
            BHA: BH1252(aspS)
            SAU: SA1456(aspS)
            SAV: SAV1617(aspS)
            LLA: L0346(aspS)
            SPY: SPy2156(aspS)
            SPN: SP2114
            SPR: spr1924(aspS)
            CAC: CAC2269(aspS) CAC2979(aspS) CAC3564(asnS)
            MGE: MG036(aspS)
            MPN: D09_orf557(aspS)
            MPU: MYPU_3320(aspS)
            UUR: UU286(aspS)
            MTU: Rv2572c(aspS)
            MTC: MT2648
            MLE: ML0501(aspS)
            CTR: CT542
            CMU: TC0829
            CPN: CPn0662
            CPA: CP0085
            CPJ: aspS
            BBU: BB0446(aspS)
            TPA: TP0985
            SYN: slr1720(aspS)
            DRA: DR1055 DR1347
            AAE: aq_1677(aspS)
            TMA: TM1441
            MJA: MJ1555(aspS)
            MTH: MTH226
            AFU: AF0920(aspS)
            HAL: VNG0461G(aspS)
            TAC: Ta0946
            TVO: TVG1147365
            PHO: PH1020
            PAB: PAB0646(aspS)
            APE: APE2192
            SSO: SSO0173(aspS)
            STO: ST0205
            SCE: YLL018C(DPS1) YPL104W(MSD1)
            SPO: SPCC1223.07C(spcc1223.07c) SPCC736.06(spcc736.06)
            ATH: At4g33760(T16L1.250)
            CEL: B0464.1 F10C2.6
            DME: CG17938 CG3821(Aats-asp)
            HSA: 1615(DARS)
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
STRUCTURES  PDB: 1EQR  1EOV  1EFW  1C0A  1B8A  1ASZ  1ASY  1G51  1IL2  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.12
            ExPASy - ENZYME nomenclature database: 6.1.1.12
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.12
            BRENDA, the Enzyme Database: 6.1.1.12
            SCOP (Structural Classification of Proteins): 6.1.1.12
///
ENTRY       EC 6.1.1.13
NAME        D-Alanine--poly(phosphoribitol) ligase
            D-Alanyl-poly(phosphoribitol) synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     D-Alanine:poly(phosphoribitol) ligase (AMP-forming)
REACTION    ATP + D-Alanine + Poly(ribitol phosphate) = AMP + Pyrophosphate +
            O-D-Alanyl-poly(ribitol phosphate)
SUBSTRATE   ATP
            D-Alanine
            Poly(ribitol phosphate)
PRODUCT     AMP
            Pyrophosphate
            O-D-Alanyl-poly(ribitol phosphate)
COMMENT     Involved in the synthesis of teichoic acids.
PATHWAY     PATH: MAP00473  D-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.13
            ExPASy - ENZYME nomenclature database: 6.1.1.13
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.13
            BRENDA, the Enzyme Database: 6.1.1.13
///
ENTRY       EC 6.1.1.14
NAME        Glycine--tRNA ligase
            Glycyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     Glycine:tRNA(Gly) ligase (AMP-forming)
REACTION    ATP + Glycine + tRNA(Gly) = AMP + Pyrophosphate +
            Glycyl-tRNA(Gly)
SUBSTRATE   ATP
            Glycine
            tRNA(Gly)
PRODUCT     AMP
            Pyrophosphate
            Glycyl-tRNA(Gly)
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b3559(glyS) b3560(glyQ)
            ECE: Z4983(glyS) Z4984(glyQ)
            ECS: ECs4442 ECs4443
            YPE: YPO4071(glyS) YPO4072(glyQ)
            HIN: HI0924(glyS) HI0927(glyQ)
            PMU: PM1098(glyQ) PM1102(glyS)
            XFA: XF1959 XF1960
            VCH: VC0020 VC0021
            PAE: PA0008(glyS) PA0009(glyQ)
            BUC: BU135(glyS) BU136(glyQ)
            NME: NMB1930 NMB1932
            NMA: NMA0521(glyQ) NMA0523(glyS)
            HPY: HP0960(glyQ) HP0972(glyS)
            HPJ: jhp0894 jhp0906
            CJE: Cj0704(glyQ) Cj1234(glyS)
            RPR: RP849(glyS) RP850(glyQ)
            RCO: RC1316(glyS) RC1317(glyQ)
            MLO: mlr7434 mlr7435
            SME: SMc00851(glyS) SMc00855(glyQ)
            CCR: CC1341 CC1342
            BSU: BG11657(glyQ) BG11658(glyS)
            BHA: BH1370(glyQ) BH1371(glyS)
            SAU: SA1394(glyS)
            SAV: SAV1554(glyS)
            LLA: L0360(glyT) L101560(glyS)
            SPY: SPy1688(glyS) SPy1689(glyQ)
            SPN: SP1474 SP1475
            SPR: spr1328(glyS) spr1329(glyQ)
            CAC: CAC3195
            MGE: MG251(glys)
            MPN: H91_orf449(glyS)
            MPU: MYPU_4510(glyS)
            UUR: UU493(glyS)
            MTU: Rv2357c(glyS)
            MTC: MT2426
            MLE: ML0826(glyS)
            CTR: CT796
            CMU: TC0178
            CPN: CPn0946
            CPA: CP0913
            CPJ: glyQ
            BBU: BB0371(glyS)
            TPA: TP0672
            SYN: slr0220(glyS) slr0638(glyQ)
            DRA: DR2059
            AAE: aq_2141(glyS) aq_945(glyQ)
            TMA: TM0216 TM0217
            MJA: MJ0228(glyS)
            MTH: MTH1846
            AFU: AF0916(glyS)
            HAL: VNG2352G(glyS)
            TAC: Ta0206
            TVO: TVG1462161
            PHO: PH1614
            PAB: PAB0380(glyS)
            APE: APE1639
            SSO: SSO0444(glyS)
            STO: ST0353
            SCE: YBR121C(GRS1) YPR081C
            SPO: SPAC3F10.03(spac3f10.03)
            CEL: T10F2.1
            DME: CG6778
            HSA: 2617(GARS)
DISEASE     MIM: 600287  Glycyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  [QY]-G-[DNEA]-x-[LIV]-[KR]-x(2)-K-x(2)-[KRNG]-[AS]-
                         x(4)-[LIV]-[DENK]-x(2)-[IV]-x(2)-L-x(3)-K
STRUCTURES  PDB: 1ATI  1B76  1GGM  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.14
            ExPASy - ENZYME nomenclature database: 6.1.1.14
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.14
            BRENDA, the Enzyme Database: 6.1.1.14
            SCOP (Structural Classification of Proteins): 6.1.1.14
///
ENTRY       EC 6.1.1.15
NAME        Proline--tRNA ligase
            Prolyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Proline:tRNA(Pro) ligase (AMP-forming)
REACTION    ATP + L-Proline + tRNA(Pro) = AMP + Pyrophosphate +
            L-Prolyl-tRNA(Pro)
SUBSTRATE   ATP
            L-Proline
            tRNA(Pro)
PRODUCT     AMP
            Pyrophosphate
            L-Prolyl-tRNA(Pro)
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0194(proS)
            ECE: Z0206(proS)
            ECS: ECs0196
            YPE: YPO1068(proS)
            HIN: HI0729(proS)
            PMU: PM1370(proS)
            XFA: XF0445
            VCH: VC0875
            PAE: PA0956(proS)
            BUC: BU239(proS)
            NME: NMB1339
            NMA: NMA1553(proS)
            HPY: HP0238(proS)
            HPJ: jhp0223
            CJE: Cj0543(proS)
            RPR: RP384(proS)
            RCO: RC0528(proS)
            MLO: mll1344
            SME: SMc01934(proS)
            CCR: CC1931
            BSU: BG12659(proS)
            BHA: BH2419(proS)
            SAU: SA1106(proS)
            SAV: SAV1251(proS)
            LLA: L0356(proS)
            SPY: SPy1962(proS)
            SPN: SP0264
            SPR: spr0243(proS)
            CAC: CAC3178(proS)
            MGE: MG283(proS)
            MPN: F11_orf483(proS)
            MPU: MYPU_1830(proS)
            UUR: UU452(proS)
            MTU: Rv2845c(proS)
            MTC: MT2911
            MLE: proS(proS)
            CTR: CT393
            CMU: TC0672
            CPN: CPn0500
            CPA: CP0254
            CPJ: proS
            BBU: BB0402(proS)
            TPA: TP0160
            SYN: sll1425(proS)
            DRA: DR1266
            AAE: aq_365(proS)
            TMA: TM0514
            MJA: MJ1238(proS)
            MTH: MTH611
            AFU: AF1609(proS)
            HAL: VNG0403G(proS)
            TAC: Ta0937
            TVO: TVG1138861
            PHO: PH1006
            PAB: PAB1724(proS)
            APE: APE2328
            SSO: SSO0569(proS)
            SCE: YER087W YHR020W
            SPO: SPBC19C7.06(spbc19c7.06) SPBC24C6.03(spbc24c6.03)
            CEL: T20H4.3 T27F6.5
            DME: CG12186 CG5394(Aats-glupro)
            HSA: 2058(EPRS)
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
            PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  [QY]-G-[DNEA]-x-[LIV]-[KR]-x(2)-K-x(2)-[KRNG]-[AS]-
                         x(4)-[LIV]-[DENK]-x(2)-[IV]-x(2)-L-x(3)-K
STRUCTURES  PDB: 1HC7  1H4Q  1H4S  1H4T  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.15
            ExPASy - ENZYME nomenclature database: 6.1.1.15
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.15
            BRENDA, the Enzyme Database: 6.1.1.15
///
ENTRY       EC 6.1.1.16
NAME        Cysteine--tRNA ligase
            Cysteinyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Cysteine:tRNA(Cys) ligase (AMP-forming)
REACTION    ATP + L-Cysteine + tRNA(Cys) = AMP + Pyrophosphate +
            L-Cysteinyl-tRNA(Cys)
SUBSTRATE   ATP
            L-Cysteine
            tRNA(Cys)
PRODUCT     AMP
            Pyrophosphate
            L-Cysteinyl-tRNA(Cys)
PATHWAY     PATH: MAP00272  Cysteine metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0526(cysS)
            ECE: Z0681(cysS)
            ECS: ECs0588
            YPE: YPO3073(cysS)
            HIN: HI0078(cysS)
            PMU: PM0945(cysS)
            XFA: XF0995
            VCH: VC1848
            PAE: PA1795(cysS)
            BUC: BU487(cysS)
            NME: NMB2083
            NMA: NMA0347(cysS)
            HPY: HP0886(cysS)
            HPJ: jhp0818
            CJE: Cj0802(cysS)
            RPR: RP085(cysS)
            RCO: RC0111(cysS)
            MLO: mlr7799
            SME: SMc02551(cysS)
            CCR: CC0460
            BSU: BG10156(cysS)
            BHA: BH0111(cysS)
            SAU: SA0488(cysS)
            SAV: SAV0520(cysS)
            LLA: L0348(cysS)
            SPY: SPy1941(cysS)
            SPN: SP0591
            SPR: spr0519(cysS)
            CAC: CAC3177(cysS)
            MGE: MG253(cysS)
            MPN: H91_orf437(cysS)
            MPU: MYPU_1770(cysS)
            UUR: UU123(cysS)
            MTU: Rv2130c(cysS2) Rv3580c(cysS)
            MTC: MT2188 MT3686
            MLE: ML0323(cysS) ML1302(cysS2)
            CTR: CT782
            CMU: TC0164
            CPN: CPn0932
            CPA: CP0931
            CPJ: cysS
            BBU: BB0599(cysS)
            TPA: TP0091
            SYN: slr0958(cysS)
            DRA: DR0705 DR1670
            AAE: aq_1068(cysS)
            TMA: TM0719 TM1410
            MJA: MJ1238(proS) MJ1477
            AFU: AF0411(cysS)
            HAL: VNG1097G(cysS)
            TAC: Ta1147
            TVO: TVG1307912
            PHO: PH0636
            PAB: PAB0931(cysS)
            APE: APE1592
            SSO: SSO2280(cysS)
            SCE: YNL247W
            SPO: SPAC30.10C(spac30.10c)
            ATH: At2g31170(F16D14.1) At5g38830(K15E6.3)
            CEL: Y23H5A.1 Y23H5A.7
            DME: CG8257 CG8431(BcDNA:LD21177)
            HSA: 833(CARS)
DISEASE     MIM: 123859  Cysteinyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.16
            ExPASy - ENZYME nomenclature database: 6.1.1.16
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.16
            BRENDA, the Enzyme Database: 6.1.1.16
///
ENTRY       EC 6.1.1.17
NAME        Glutamate--tRNA ligase
            Glutamyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Glutamate:tRNA(Glu) ligase (AMP-forming)
REACTION    ATP + L-Glutamate + tRNA(Glu) = AMP + Pyrophosphate +
            L-Glutamyl-tRNA(Glu)
SUBSTRATE   ATP
            L-Glutamate
            tRNA(Glu)
PRODUCT     AMP
            Pyrophosphate
            L-Glutamyl-tRNA(Glu)
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00860  Porphyrin and chlorophyll metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b2400(gltX)
            ECE: Z3665(gltX)
            ECS: ECs3278
            YPE: YPO2984(gltX)
            HIN: HI0274(gltX)
            PMU: PM1115(gltX_2)
            XFA: XF0822
            VCH: VC2214
            PAE: PA3134(gltX)
            BUC: BU070(gltX)
            NME: NMB0003
            NMA: NMA0250(gltX)
            HPY: HP0476(gltX) HP0643(gltX)
            HPJ: jhp0428 jhp0588
            CJE: Cj0845c(gltX) Cj1288c(gltX2)
            RPR: RP325(gltX1) RP623(gltX2)
            RCO: RC0448(gltX1) RC0966(gltX2)
            MLO: mll0813 mlr0628
            SME: SMc03172(gltX)
            CCR: CC1905
            BSU: BG10154(gltX)
            BHA: BH0109(gltX)
            SAU: SA0486(gltX)
            SAV: SAV0518(gltX)
            LLA: L0349(gltX)
            SPY: SPy0239(gltX)
            SPN: SP2069
            SPR: spr1881(gltX)
            CAC: CAC0990(gltX)
            MGE: MG462(gltX)
            MPN: K05_orf484(gltX)
            MPU: MYPU_6810(gltX) MYPU_6820(gltX)
            UUR: UU599(gltX)
            MTU: Rv2992c(gltS)
            MTC: MT3070
            MLE: ML1688(gltS)
            CTR: CT445
            CMU: TC0730
            CPN: CPn0560
            CPA: CP0190
            CPJ: gltX
            BBU: BB0372(gltX)
            TPA: TP0673
            SYN: sll0179(gltX)
            DRA: DR0485
            AAE: aq_1221(gltX)
            TMA: TM1351 TM1875
            MJA: MJ1377(gltX)
            MTH: MTH51(gltX)
            AFU: AF0260(gltX)
            HAL: VNG1153G(gltS)
            TAC: Ta0942
            TVO: TVG1143889
            PHO: PH1686
            PAB: PAB0323(gltX)
            APE: APE2317
            SSO: SSO0093(gltX)
            SCE: YGL245W YOL033W(MSE1)
            SPO: SPAC17A5.15C(spac17a5.15c)
            CEL: T07A9.2 ZC434.5
            DME: CG4573 CG5394(Aats-glupro)
            HSA: 2058(EPRS)
DISEASE     MIM: 138295  Glutamyl-prolyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
            PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  [QY]-G-[DNEA]-x-[LIV]-[KR]-x(2)-K-x(2)-[KRNG]-[AS]-
                         x(4)-[LIV]-[DENK]-x(2)-[IV]-x(2)-L-x(3)-K
STRUCTURES  PDB: 1G59  1FYJ  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.17
            ExPASy - ENZYME nomenclature database: 6.1.1.17
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.17
            BRENDA, the Enzyme Database: 6.1.1.17
///
ENTRY       EC 6.1.1.18
NAME        Glutamine--tRNA ligase
            Glutaminyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Glutamine:tRNA(Gln) ligase (AMP-forming)
REACTION    ATP + L-Glutamine + tRNA(Gln) = AMP + Pyrophosphate +
            L-Glutaminyl-tRNA(Gln)
SUBSTRATE   ATP
            L-Glutamine
            tRNA(Gln)
PRODUCT     AMP
            Pyrophosphate
            L-Glutaminyl-tRNA(Gln)
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0680(glnS)
            ECE: Z0827(glnS)
            ECS: ECs0710
            YPE: YPO2630(glnS)
            HIN: HI1354(glnS)
            PMU: PM0528(glnS)
            XFA: XF1338
            VCH: VC0997
            PAE: PA1794(glnS)
            BUC: BU415(glnS)
            NME: NMB1560
            NMA: NMA1748(glnS)
            DRA: DR2611
            SCE: YOR168W(GLN4)
            SPO: SPBC342.02(spbc342.02)
            CEL: Y41E3.4
            DME: CG10506(BcDNA:GH11673)
            HSA: 5859(QARS)
DISEASE     MIM: 603727  Glutaminyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1QTQ  1GTR  1EUQ  1EUY  1QRU  1QRT  1QRS  1GTS  1EXD  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.18
            ExPASy - ENZYME nomenclature database: 6.1.1.18
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.18
            BRENDA, the Enzyme Database: 6.1.1.18
            SCOP (Structural Classification of Proteins): 6.1.1.18
///
ENTRY       EC 6.1.1.19
NAME        Arginine--tRNA ligase
            Arginyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Arginine:tRNA(Arg) ligase (AMP-forming)
REACTION    ATP + L-Arginine + tRNA(Arg) = AMP + Pyrophosphate +
            L-Arginyl-tRNA(Arg)
SUBSTRATE   ATP
            L-Arginine
            tRNA(Arg)
PRODUCT     AMP
            Pyrophosphate
            L-Arginyl-tRNA(Arg)
PATHWAY     PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b1876(argS)
            ECE: Z2929(argS)
            ECS: ECs2586
            YPE: YPO2046(argS)
            HIN: HI1583(argS)
            PMU: PM0551(argS)
            XFA: XF0147
            VCH: VC2074
            PAE: PA5051(argS)
            BUC: BU242(argS)
            NME: NMB1506
            NMA: NMA1707(argS)
            HPY: HP0319(argS)
            HPJ: jhp0302
            CJE: Cj1175c(argS)
            RPR: RP065(argS)
            RCO: RC0095(argS)
            MLO: mll1091
            SME: SMc02073(argS)
            CCR: CC3359
            BSU: BG11341(argS)
            BHA: BH0834 BH3808(argS)
            SAU: SA0564(argS)
            SAV: SAV0597(argS)
            LLA: L0344(argS)
            SPY: SPy2151(argS)
            SPN: SP2078
            SPR: spr1890(argS)
            CAC: CAC1041(argS)
            MGE: MG378(argS)
            MPN: H03_orf537(argS)
            MPU: MYPU_2430(argS)
            UUR: UU278(argS)
            MTU: Rv1292(argS)
            MTC: MT1331
            MLE: ML1127(argS)
            CTR: CT454
            CMU: TC0739
            CPN: CPn0570
            CPA: CP0179
            CPJ: argS
            BBU: BB0594(argS)
            TPA: TP0831(argS)
            SYN: sll0502(argS)
            DRA: DR2568
            AAE: aq_923(argS)
            TMA: TM1093
            MJA: MJ0237(argS)
            MTH: MTH1447
            AFU: AF0894(argS)
            HAL: VNG6312G(argS)
            TAC: Ta0281
            TVO: TVG1388781
            PHO: PH1478
            PAB: PAB0469(argS)
            APE: APE1756
            SSO: SSO0857(argS)
            STO: ST1258
            SCE: YDR341C YHR091C(MSR1)
            SPO: SPBC25B2.09C(spbc25b2.09c)
            ATH: At1g66530(F28G11.14) At4g26300(T25K17.110)
            CEL: C29H12.1 F26F4.10
            DME: CG10092 CG9020
            HSA: 5917(RARS)
DISEASE     MIM: 107820  Arginyl-tRNA synthetase
MOTIF       PS: PS00178  P-x(0,2)-[GSTAN]-[DENQGAPK]-x-[LIVMFP]-[HT]-[LIVMYAC]-
                         G-[HNTG]-[LIVMFYSTAGPC]
STRUCTURES  PDB: 1F7V  1F7U  1BS2  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.19
            ExPASy - ENZYME nomenclature database: 6.1.1.19
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.19
            BRENDA, the Enzyme Database: 6.1.1.19
            SCOP (Structural Classification of Proteins): 6.1.1.19
///
ENTRY       EC 6.1.1.20
NAME        Phenylalanine--tRNA ligase
            Phenylalanyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)
REACTION    ATP + L-Phenylalanine + tRNA(Phe) = AMP + Pyrophosphate +
            L-Phenylalanyl-tRNA(Phe)
SUBSTRATE   ATP
            L-Phenylalanine
            tRNA(Phe)
PRODUCT     AMP
            Pyrophosphate
            L-Phenylalanyl-tRNA(Phe)
PATHWAY     PATH: MAP00400  Phenylalanine, tyrosine and tryptophan biosynthesis
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b1713(pheT) b1714(pheS)
            ECE: Z2742(pheT) Z2743(pheS)
            ECS: ECs2420 ECs2421
            YPE: YPO2428(pheT) YPO2429(pheS)
            HIN: HI1311(pheS) HI1312(pheT)
            PMU: PM0629(pheT) PM0631(pheS)
            XFA: XF0741 XF0742
            VCH: VC1219 VC1220
            PAE: PA2739(pheT) PA2740(pheS)
            BUC: BU129(pheS) BU130(pheT)
            NME: NMB0724 NMB0728
            NMA: NMA0933(pheS) NMA0937(pheT)
            HPY: HP0402(pheT) HP0403(pheS)
            HPJ: jhp0978 jhp0979
            CJE: Cj0896c(pheT) Cj0897c(pheS)
            RPR: RP417(pheS) RP418(pheT)
            RCO: RC0581(pheS) RC0582(pheT)
            MLO: mll5053 mll5055
            SME: SMc00365(pheS) SMc00366(pheT)
            CCR: CC1043 CC1044
            BSU: BG10874(pheS) BG10875(pheT)
            BHA: BH3110(pheT) BH3111(pheS)
            SAU: SA0985(pheS) SA0986(pheT)
            SAV: SAV1119(pheS) SAV1120(pheT)
            LLA: L0354(pheS) L0355(pheT)
            SPY: SPy0768(pheS) SPy0769(pheT)
            SPN: SP0579 SP0581
            SPR: spr0507(pheS) spr0509(pheT)
            CAC: CAC2356(pheT) CAC2357(pheS)
            MGE: MG194(pheS) MG195(pheT)
            MPN: C09_orf341(pheS) C09_orf805(pheT)
            MPU: MYPU_3470(pheT) MYPU_3480(pheS)
            UUR: UU457(pheT) UU458(pheS)
            MTU: Rv1649(pheS) Rv1650(pheT)
            MTC: MT1687 MT1688
            MLE: ML1401(pheS) ML1402(pheT)
            CTR: CT475 CT836
            CMU: TC0224 TC0760
            CPN: CPn0594 CPn0993
            CPA: CP0154 CP0862
            CPJ: pheS pheT
            BBU: BB0513(pheS) BB0514(pheT)
            TPA: TP0015 TP0973
            SYN: sll0454(pheS) sll1553(pheT)
            DRA: DR2354 DR2357
            AAE: aq_1730(pheT) aq_953(pheS)
            TMA: TM0821 TM0822
            MJA: MJ0487 MJ1108(pheT) MJ1660
            MTH: MTH1501 MTH742 MTH770
            AFU: AF1424(pheT) AF1955(pheS)
            HAL: VNG2504G(pheS) VNG2505G(pheY)
            TAC: Ta0551 Ta0639
            TVO: TVG0596849 TVG1092683
            PHO: PH0657 PH0658
            PAB: PAB2426(pheS) PAB2427(pheT)
            APE: APE2302 APE2305
            SSO: SSO0100(pheS) SSO0101(pheT)
            SCE: YFL022C(FRS2) YLR060W(FRS1) YPR047W(MSF1)
            SPO: SPAC23A1.12C(spac23a1.12c) SPAC3G9.06(spac3g9.06)
                 SPCC736.03C(spcc736.03c)
            CEL: F22B5.9 T08B2.9
            DME: CG13348(Aats-phe) CG2263 CG5706
            HSA: 10056(PheHB) 10667(FARS1) 2193(FARSL)
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
STRUCTURES  PDB: 1B7Y  1PYS  1EIY  1B70  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.20
            ExPASy - ENZYME nomenclature database: 6.1.1.20
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.20
            BRENDA, the Enzyme Database: 6.1.1.20
            SCOP (Structural Classification of Proteins): 6.1.1.20
///
ENTRY       EC 6.1.1.21
NAME        Histidine--tRNA ligase
            Histidyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Histidine:tRNA(His) ligase (AMP-forming)
REACTION    ATP + L-Histidine + tRNA(His) = AMP + Pyrophosphate +
            L-Histidyl-tRNA(His)
SUBSTRATE   ATP
            L-Histidine
            tRNA(His)
PRODUCT     AMP
            Pyrophosphate
            L-Histidyl-tRNA(His)
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b2514(hisS)
            ECE: Z3777(hisS)
            ECS: ECs3376
            YPE: YPO2878(hisS)
            HIN: HI0369(hisS)
            PMU: PM2011(hisS)
            XFA: XF2222
            VCH: VC0760
            PAE: PA3802(hisS)
            BUC: BU288(hisS)
            NME: NMB0854(hisS)
            NMA: NMA1065(hisS)
            HPY: HP1190(hisS)
            HPJ: jhp1115
            CJE: Cj0765c(hisS)
            RPR: RP308(hisS)
            RCO: RC0412(hisS)
            MLO: mlr6928
            SME: SMc00919(hisS)
            CCR: CC3513
            BSU: BG12605(hisS)
            BHA: BH1251(hisS)
            SAU: SA1457(hisS)
            SAV: SAV1618(hisS)
            LLA: L0342(hisS)
            SPY: SPy2157(hisS)
            SPN: SP2121
            SPR: spr1931(hisS)
            CAC: CAC2740(hisS)
            MGE: MG035(hisS)
            MPN: B01_orf414o(hisS)
            MPU: MYPU_3330(hisS)
            UUR: UU285(hisS)
            MTU: Rv2580c(hisS)
            MTC: MT2657
            MLE: ML0494(hisS)
            CTR: CT543
            CMU: TC0830
            CPN: CPn0663
            CPA: CP0084
            CPJ: hisS
            BBU: BB0135(hisS)
            TPA: TP0641
            SYN: slr0357(hisS)
            DRA: DR1349(hisS)
            AAE: aq_122(hisS)
            TMA: TM1043 TM1090
            MJA: MJ1000(hisS)
            MTH: MTH244
            AFU: AF1642(hisS)
            HAL: VNG2005G(hisS)
            TAC: Ta0099
            TVO: TVG0164058
            PHO: PH0290
            PAB: PAB1100(hisS)
            APE: APE0662
            SSO: SSO0279(hisS)
            STO: ST0323
            SCE: YPR033C(HTS1)
            SPO: SPBC2G2.12(spbc2g2.12)
            CEL: T11G6.1
            DME: CG6335
            HSA: 3035(HARS)
DISEASE     MIM: 142810  Histidyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
            PS: PS00762  [QY]-G-[DNEA]-x-[LIV]-[KR]-x(2)-K-x(2)-[KRNG]-[AS]-
                         x(4)-[LIV]-[DENK]-x(2)-[IV]-x(2)-L-x(3)-K
STRUCTURES  PDB: 1KMN  1KMM  1HTT  1H4V  1ADY  1ADJ  1QE0  
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.21
            ExPASy - ENZYME nomenclature database: 6.1.1.21
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.21
            BRENDA, the Enzyme Database: 6.1.1.21
            SCOP (Structural Classification of Proteins): 6.1.1.21
///
ENTRY       EC 6.1.1.22
NAME        Asparagine--tRNA ligase
            Asparaginyl-tRNA synthetase
CLASS       Ligases
            Forming carbon-oxygen bonds
            Ligases forming aminoacyl-tRNA and related compounds
SYSNAME     L-Asparagine:tRNA(Asn) ligase (AMP-forming)
REACTION    ATP + L-Asparagine + tRNA(Asn) = AMP + Pyrophosphate +
            L-Asparaginyl-tRNA(Asn)
SUBSTRATE   ATP
            L-Asparagine
            tRNA(Asn)
PRODUCT     AMP
            Pyrophosphate
            L-Asparaginyl-tRNA(Asn)
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00970  Aminoacyl-tRNA biosynthesis
GENES       ECO: b0930(asnS)
            ECE: Z1278(asnS)
            ECS: ECs1013
            YPE: YPO1412(asnS)
            HIN: HI1302(asnS)
            PMU: PM0643(asnS)
            XFA: XF2563
            VCH: VC1297
            BUC: BU360(asnS)
            BSU: BG10958(asnS)
            BHA: BH1696(asnS)
            SAU: SA1287(asnS)
            SAV: SAV1442(asnS)
            LLA: L0345(asnS)
            SPY: SPy0651(asnS)
            SPN: SP1542
            SPR: spr1397(asnS)
            CAC: CAC3260(asnS)
            MGE: MG113(asnS)
            MPN: K04_orf455o(asnS)
            MPU: MYPU_7710(asnS)
            UUR: UU365(asnS)
            BBU: BB0101(asnS)
            TPA: TP0609
            SYN: sll0495(asnS)
            TAC: Ta0519
            TVO: TVG1050051
            PHO: PH0241
            PAB: PAB2203(ASNRS)
            SCE: YCR024C YHR019C(DED81)
            SPO: SPBC1198.10C(spbc1198.10c) SPBC1773.10C(spbc1773.10c)
            CEL: F22D6.3
            DME: CG10687(BcDNA:GH06451) CG6796
            HSA: 4677(NARS)
DISEASE     MIM: 108410  Asparaginyl-tRNA synthetase
MOTIF       PS: PS00179  [FYH]-R-x-[DE]-x(4,12)-[RH]-x(3)-F-x(3)-[DE]
            PS: PS00339  [GSTALVF]-{DENQHRKP}-[GSTA]-[LIVMF]-[DE]-R-[LIVMF]-x-
                         [LIVMSTAG]-[LIVMFY]
DBLINKS     IUBMB Enzyme Nomenclature: 6.1.1.22
            ExPASy - ENZYME nomenclature database: 6.1.1.22
            WIT (What Is There) Metabolic Reconstruction: 6.1.1.22
            BRENDA, the Enzyme Database: 6.1.1.22
///
ENTRY       EC 6.2.1.1
NAME        Acetate--CoA ligase
            Acetyl-CoA synthetase
            Acetyl activating enzyme
            Acetate thiokinase
            Acyl-activating enzyme
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acetate:CoA ligase (AMP-forming)
REACTION    ATP + Acetate + CoA = AMP + Pyrophosphate + Acetyl-CoA
SUBSTRATE   ATP
            Acetate
            CoA
            Propanoate
            Propenoate
PRODUCT     AMP
            Pyrophosphate
            Acetyl-CoA
            Propanoyl-CoA
            Propenoyl-CoA
COMMENT     Also acts on propanoate and propenoate.
PATHWAY     PATH: MAP00010  Glycolysis / Gluconeogenesis
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b4069(acs)
            ECE: Z5668(acs)
            ECS: ECs5051
            YPE: YPO0253(acs)
            PMU: PM0692(acsA)
            XFA: XF2255
            VCH: VC0298 VCA0829
            PAE: PA0887(acsA) PA1997 PA4733(acsB)
            HPY: HP1045(acoE)
            CJE: Cj1537c(acs)
            MLO: mll6017 mlr4089
            SME: SMc04093(acsA1)
            CCR: CC3581
            BSU: BG10370(acsA) BG13834(ytcI)
            BHA: BH1137 BH3201 BH3234(acsA)
            SAU: SA1554(acsA) SA2402
            SAV: SAV1720(acsA) SAV2593
            MTU: Rv3667(acs)
            MTC: MT3768
            SYN: sll0542(acs)
            DRA: DR0460 DR2471
            AAE: aq_2103(acs') aq_2104(acs)
            MTH: MTH1603 MTH1604 MTH216 MTH217 MTH701 MTH702
            AFU: AF0197(acs-1) AF0366(acs-2) AF0677(acs-3) AF0975(acs-4)
                 AF0976(acs-5) AF1287(acs-6) AF2389
            HAL: VNG0484G(acs1) VNG0997G(acs2)
            TAC: Ta0229 Ta0421 Ta0769 Ta1508
            TVO: TVG0130538 TVG1206092 TVG1328971 TVG1331499
            APE: APE1346 APE2604 APES074
            SSO: SSO1340(acsA-2) SSO1342(acsA-2) SSO1903(acsA-3)
                 SSO2041(acsA-5) SSO2059(acsA-6) SSO2070(acsA-7)
                 SSO2216(acsA-8) SSO2863(acsA-9) SSO3203(acsA-10)
            STO: ST0050 ST0730 ST0783 ST1190
            SCE: YAL054C(ACS1) YLR153C(ACS2)
            SPO: SPCC417.14C
            CEL: C36A4.9 K03A1.5
            DME: CG9390(AcCoAS) CG9390_1(AcCoAS)
            HSA: 54988(FLJ20581)
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.1
            ExPASy - ENZYME nomenclature database: 6.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.1
            BRENDA, the Enzyme Database: 6.2.1.1
///
ENTRY       EC 6.2.1.2
NAME        Butyrate--CoA ligase
            Butyryl-CoA synthetase
            Fatty acid thiokinase (medium chain)
            Acyl-activating enzyme
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Butanoate:CoA ligase (AMP-forming)
REACTION    ATP + an Acid + CoA = AMP + Pyrophosphate + an Acyl-CoA
SUBSTRATE   ATP
            Acid
            CoA
PRODUCT     AMP
            Pyrophosphate
            Acyl-CoA
COMMENT     Acts on acids from C4 to C11 and on the corresponding
            3-hydroxy- and 2,3- or 3,4-unsaturated acids.
PATHWAY     PATH: MAP00650  Butanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.2
            ExPASy - ENZYME nomenclature database: 6.2.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.2
            BRENDA, the Enzyme Database: 6.2.1.2
///
ENTRY       EC 6.2.1.3
NAME        Long-chain-fatty-acid--CoA ligase
            Acyl-CoA synthetase
            Fatty acid thiokinase (long chain)
            Acyl-activating enzyme
            Palmitoyl-CoA synthase
            Lignoceroyl-CoA synthase
            Arachidonyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acid:CoA ligase (AMP-forming)
REACTION    ATP + a Long-chain carboxylic acid + CoA = AMP + Pyrophosphate +
            an Acyl-CoA
SUBSTRATE   ATP
            Long-chain carboxylic acid
            Fatty acid
            CoA
PRODUCT     AMP
            Pyrophosphate
            Acyl-CoA
COFACTOR    Magnesium
COMMENT     Acts on a wide range of long-chain saturated and unsaturated
            fatty acids, but the enzymes from different tissues show some
            variation in specificity. The liver enzyme acts on acids from
            C6 to C20; that from brain shows high activity up to C24.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       ECO: b1805(fadD)
            ECE: Z2848(fadD)
            ECS: ECs2514
            YPE: YPO2074(fadD)
            HIN: HI0002 HI0390.1(fadD)
            PMU: PM0707(fadD_1) PM0925(fadD_2)
            VCH: VC1985 VC2484
            PAE: PA2557 PA3299(fadD1) PA3300(fadD2)
            NME: NMB1276 NMB1555
            NMA: NMA1482 NMA1743(fadD)
            MLO: mll5415 mlr6932
            SME: SMc02162(fadD)
            CCR: CC0966 CC1321
            BSU: BG11946(lcfA) BG13057(yhfL) BG13064(yhfT) BG13460(yngI)
            BHA: BH1131 BH2006 BH3103 BH3104
            SAU: SA0226
            SAV: SAV0227(fadD)
            MTU: Rv0214(fadD4) Rv0404(fadD30) Rv1521(fadD25) Rv2187(fadD15)
                 Rv2505c(fadD35) Rv3561(fadD3)
            MTC: MT0224 MT0417 MT1572 MT2242 MT2580 MT3666
            MLE: ML0887
            BBU: BB0137 BB0593
            SYN: slr1609
            DRA: DR1692 DRA0309
            AAE: aq_999(fadD)
            MTH: MTH657
            AFU: AF0089(fadD-1) AF0200(fadD-2) AF0687(fadD-3) AF0840(fadD-4)
                 AF1029(fadD-5) AF1510(fadD-6) AF1772(fadD-7) AF1932(fadD-8)
                 AF2368(fadD-9)
            HAL: VNG1073G(lfl1) VNG2071G(lfl2)
            APE: APE1307 APE1310 APE2284
            SSO: SSO0369(fadD-1) SSO2523(fadD-2) SSO3064(fadD-3)
            STO: ST1112
            SCE: YER015W(FAA2) YIL009W(FAA3) YMR246W(FAA4) YOR317W(FAA1)
            SPO: SPBC18H10.02(spbc18h10.02)
            CEL: C46F4.2 F28F8.2 F37C12.7 F41C3.3 F47G6.2 R09E10.3 R09E10.4
                 T08B1.6 Y76A2B.3 ZK1127.2
            DME: CG12512 CG3961 CG4500(BG:DS05899.1) CG4501(BG:DS01514.2)
            HSA: 2179(FACL1) 2180(FACL2) 2181(FACL3) 2182(FACL4) 51703(FACL5)
DISEASE     MIM: 152426  Fatty-acid-Coenzyme A ligase, long-chain 2
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.3
            ExPASy - ENZYME nomenclature database: 6.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.3
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.3
            BRENDA, the Enzyme Database: 6.2.1.3
///
ENTRY       EC 6.2.1.4
NAME        Succinate--CoA ligase (GDP-forming)
            Succinyl-CoA synthetase (GDP-forming)
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Succinate:CoA ligase (GDP-forming)
REACTION    GTP + Succinate + CoA = GDP + Orthophosphate + Succinyl-CoA;
            ITP + Succinate + CoA = IDP + Orthophosphate + Succinyl-CoA;
            GTP + Itaconate + CoA = GDP + Orthophosphate + Itaconyl-CoA;
            ITP + Itaconate + CoA = IDP + Orthophosphate + Itaconyl-CoA
SUBSTRATE   GTP
            Succinate
            CoA
            Itaconate
            ITP
PRODUCT     GDP
            Orthophosphate
            Succinyl-CoA
            Itaconyl-CoA
            IDP
COMMENT     Itaconate can act instead of succinate and ITP instead of GTP.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00640  Propanoate metabolism
GENES       SCE: YGR244C(LSC2) YOR142W(LSC1)
            SPO: SPAC16E8.17C(spac16e8.17c) SPCC1620.08(spcc1620.08)
            CEL: C05G5.4 C50F7.4 F47B10.1
            DME: CG10622 CG1065(Scsalpha) CG11963 CG6255
            HSA: 8802(SUCLG1) 8803(SUCLA2)
MOTIF       PS: PS00399  G-x(2)-A-x(4,7)-[RQT]-[LIVMF]-G-H-[AS]-[GH]
            PS: PS01216  S-[KR]-S-G-[GT]-[LIVM]-[GST]-x-[EQ]-x(8,10)-G-x(4)-
                         [LIVM]-[GA]-[LIVM]-G-G-D
            PS: PS01217  G-x-[IV]-x(2)-[LIVMF]-x-[NA]-G-[GA]-G-[LMA]-[STAV]-
                         x(4)-D-x-[LIVM]-x(3)-G-[GREA]
STRUCTURES  PDB: 1EUC  1EUD  
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.4
            ExPASy - ENZYME nomenclature database: 6.2.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.4
            BRENDA, the Enzyme Database: 6.2.1.4
            SCOP (Structural Classification of Proteins): 6.2.1.4
///
ENTRY       EC 6.2.1.5
NAME        Succinate--CoA ligase (ADP-forming)
            Succinyl-CoA synthetase (ADP-forming)
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Succinate:CoA ligase (ADP-forming)
REACTION    ATP + Succinate + CoA = ADP + Orthophosphate + Succinyl-CoA
SUBSTRATE   ATP
            Succinate
            CoA
PRODUCT     ADP
            Orthophosphate
            Succinyl-CoA
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00640  Propanoate metabolism
            PATH: MAP00660  C5-Branched dibasic acid metabolism
            PATH: MAP00720  Reductive carboxylate cycle (CO2 fixation)
GENES       ECO: b0728(sucC) b0729(sucD)
            ECE: Z0882(sucC) Z0883(sucD)
            ECS: ECs0753 ECs0754
            YPE: YPO1115(sucC) YPO1116(sucD)
            HIN: HI1196(sucC) HI1197(sucD)
            PMU: PM0280(sucC) PM0281(sucD)
            XFA: XF2547 XF2548
            VCH: VC2084 VC2085
            PAE: PA1588(sucC) PA1589(sucD)
            NME: NMB0959 NMB0960
            NMA: NMA1153(sucC) NMA1154(sucD)
            CJE: Cj0533(sucC) Cj0534(sucD)
            RPR: RP432(sucD) RP433(sucC)
            RCO: RC0598(sucD) RC0599(sucC)
            MLO: mll4303 mll4306 mlr1324 mlr1326
            SME: SMc02480(sucC) SMc02481(sucD)
            CCR: CC0337 CC0338
            BSU: BG12680(sucC) BG12681(sucD)
            BHA: BH2469(sucD) BH2470(sucC)
            SAU: SA1088(sucC) SA1089(sucD)
            SAV: SAV1232(sucC) SAV1233(sucD)
            MTU: Rv0951(sucC) Rv0952(sucD)
            MTC: MT0978 MT0979
            MLE: ML0155(sucC) ML0156(sucD)
            CTR: CT821 CT822
            CMU: TC0208 TC0209
            CPN: CPn0973 CPn0974
            CPA: CP0885 CP0886
            CPJ: sucC sucD
            SYN: sll1023(sucC) sll1557(sucD)
            DRA: DR1247 DR1248
            AAE: aq_1306(sucC1) aq_1620(sucC2) aq_1622(sucD2) aq_1888(sucD1)
            MJA: MJ0210(sucC) MJ1246(sucD)
            MTH: MTH1036 MTH563
            AFU: AF1539(sucD-1) AF1540(sucC-1) AF2185(sucD-2) AF2186(sucC-2)
            HAL: VNG1541G(sucC) VNG1542G(sucD)
            TAC: Ta1331 Ta1332
            TVO: TVG0284189 TVG0285047
            APE: APE1065 APE1072
            SSO: SSO2482(sucD) SSO2483(sucC)
            STO: ST0962 ST0963
MOTIF       PS: PS00399  G-x(2)-A-x(4,7)-[RQT]-[LIVMF]-G-H-[AS]-[GH]
            PS: PS01216  S-[KR]-S-G-[GT]-[LIVM]-[GST]-x-[EQ]-x(8,10)-G-x(4)-
                         [LIVM]-[GA]-[LIVM]-G-G-D
            PS: PS01217  G-x-[IV]-x(2)-[LIVMF]-x-[NA]-G-[GA]-G-[LMA]-[STAV]-
                         x(4)-D-x-[LIVM]-x(3)-G-[GREA]
STRUCTURES  PDB: 1CQI  1CQJ  1SCU  2SCU  
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.5
            ExPASy - ENZYME nomenclature database: 6.2.1.5
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.5
            BRENDA, the Enzyme Database: 6.2.1.5
            SCOP (Structural Classification of Proteins): 6.2.1.5
///
ENTRY       EC 6.2.1.6
NAME        Glutarate--CoA ligase
            Glutaryl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Glutarate:CoA ligase (ADP-forming)
REACTION    ATP + Glutarate + CoA = ADP + Orthophosphate + Glutaryl-CoA
SUBSTRATE   ATP
            Glutarate
            CoA
            GTP
            ITP
PRODUCT     ADP
            Orthophosphate
            Glutaryl-CoA
            GDP
            IDP
COMMENT     GTP or ITP can act instead of ATP.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
            PATH: MAP00310  Lysine degradation
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.6
            ExPASy - ENZYME nomenclature database: 6.2.1.6
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.6
            BRENDA, the Enzyme Database: 6.2.1.6
///
ENTRY       EC 6.2.1.7
NAME        Cholate--CoA ligase
            Choloyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Cholate:CoA ligase (AMP-forming)
REACTION    ATP + Cholate + CoA = AMP + Pyrophosphate + Choloyl-CoA
SUBSTRATE   ATP
            Cholate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Choloyl-CoA
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.7
            ExPASy - ENZYME nomenclature database: 6.2.1.7
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.7
            BRENDA, the Enzyme Database: 6.2.1.7
///
ENTRY       EC 6.2.1.8
NAME        Oxalate--CoA ligase
            Oxalyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Oxalate:CoA ligase (AMP-forming)
REACTION    ATP + Oxalate + CoA = AMP + Pyrophosphate + Oxalyl-CoA
SUBSTRATE   ATP
            Oxalate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Oxalyl-CoA
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.8
            ExPASy - ENZYME nomenclature database: 6.2.1.8
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.8
            BRENDA, the Enzyme Database: 6.2.1.8
///
ENTRY       EC 6.2.1.9
NAME        Malate--CoA ligase
            Malyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Malate:CoA ligase (ADP-forming)
REACTION    ATP + Malate + CoA = ADP + Orthophosphate + L-Malyl-CoA
SUBSTRATE   ATP
            Malate
            CoA
PRODUCT     ADP
            Orthophosphate
            L-Malyl-CoA
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
MOTIF       PS: PS00399  G-x(2)-A-x(4,7)-[RQT]-[LIVMF]-G-H-[AS]-[GH]
            PS: PS01216  S-[KR]-S-G-[GT]-[LIVM]-[GST]-x-[EQ]-x(8,10)-G-x(4)-
                         [LIVM]-[GA]-[LIVM]-G-G-D
            PS: PS01217  G-x-[IV]-x(2)-[LIVMF]-x-[NA]-G-[GA]-G-[LMA]-[STAV]-
                         x(4)-D-x-[LIVM]-x(3)-G-[GREA]
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.9
            ExPASy - ENZYME nomenclature database: 6.2.1.9
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.9
            BRENDA, the Enzyme Database: 6.2.1.9
///
ENTRY       EC 6.2.1.10
NAME        Acid--CoA ligase (GDP-forming)
            Acyl-CoA synthetase (GDP-forming)
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acid:CoA ligase (GDP-forming)
REACTION    GTP + an Acid + CoA = GDP + Orthophosphate + an Acyl-CoA
SUBSTRATE   GTP
            Acid
            CoA
PRODUCT     GDP
            Orthophosphate
            Acyl-CoA
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.10
            ExPASy - ENZYME nomenclature database: 6.2.1.10
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.10
            BRENDA, the Enzyme Database: 6.2.1.10
///
ENTRY       EC 6.2.1.11
NAME        Biotin--CoA ligase
            Biotinyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Biotin:CoA ligase (AMP-forming)
REACTION    ATP + Biotin + CoA = AMP + Pyrophosphate + Biotinyl-CoA
SUBSTRATE   ATP
            Biotin
            CoA
PRODUCT     AMP
            Pyrophosphate
            Biotinyl-CoA
PATHWAY     PATH: MAP00780  Biotin metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.11
            ExPASy - ENZYME nomenclature database: 6.2.1.11
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.11
            BRENDA, the Enzyme Database: 6.2.1.11
///
ENTRY       EC 6.2.1.12
NAME        4-Coumarate--CoA ligase
            4-Coumaroyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     4-Coumarate:CoA ligase (AMP-forming)
REACTION    ATP + 4-Coumarate + CoA = AMP + Pyrophosphate + 4-Coumaroyl-CoA
SUBSTRATE   ATP
            4-Coumarate
            CoA
PRODUCT     AMP
            Pyrophosphate
            4-Coumaroyl-CoA
PATHWAY     PATH: MAP00940  Flavonoids, stilbene and lignin biosynthesis
GENES       CEL: AH10.1 C01G6.7 F11A3.1
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.12
            ExPASy - ENZYME nomenclature database: 6.2.1.12
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.12
            BRENDA, the Enzyme Database: 6.2.1.12
///
ENTRY       EC 6.2.1.13
NAME        Acetate--CoA ligase (ADP-forming)
            Acetyl-CoA synthetase (ADP-forming)
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acetate:CoA ligase (ADP-forming)
REACTION    ATP + Acetate + CoA = ADP + Orthophosphate + Acetyl-CoA
SUBSTRATE   ATP
            Acetate
            CoA
            Propanoate
PRODUCT     ADP
            Orthophosphate
            Acetyl-CoA
            Propanoyl-CoA
COMMENT     Also acts on propanoate and, very slowly, on butanoate.
PATHWAY     PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.13
            ExPASy - ENZYME nomenclature database: 6.2.1.13
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.13
            BRENDA, the Enzyme Database: 6.2.1.13
///
ENTRY       EC 6.2.1.14
NAME        6-Carboxyhexanoate--CoA ligase
            6-Carboxyhexanoyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     6-Carboxyhyxanoate:CoA ligase (AMP-forming)
REACTION    ATP + 6-Carboxyhexanoate + CoA = AMP + Pyrophosphate +
            6-Carboxyhexanoyl-CoA
SUBSTRATE   ATP
            6-Carboxyhexanoate
            CoA
PRODUCT     AMP
            Pyrophosphate
            6-Carboxyhexanoyl-CoA
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       BSU: BG11529(bioW)
            SAU: SA2211
            SAV: SAV2407(bioW)
            AAE: aq_1659(bioW)
            MJA: MJ1297(bioW)
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.14
            ExPASy - ENZYME nomenclature database: 6.2.1.14
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.14
            BRENDA, the Enzyme Database: 6.2.1.14
///
ENTRY       EC 6.2.1.15
NAME        Arachidonate--CoA ligase
            Arachidonoyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Arachidonate:CoA ligase (AMP-forming)
REACTION    ATP + Arachidonate + CoA = AMP + Pyrophosphate + Arachidonyl-CoA
SUBSTRATE   ATP
            Arachidonate
            CoA
            8,11,14-Eicosatrienoate
PRODUCT     AMP
            Pyrophosphate
            Arachidonyl-CoA
            8,11,14-Eicosatrienoyl-CoA
COMMENT     Not identical with EC 6.2.1.3. 8,11,14-Eicosatrienoate, but not the
            other long-chain fatty acids, can act in place of arachidonate.
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.15
            ExPASy - ENZYME nomenclature database: 6.2.1.15
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.15
            BRENDA, the Enzyme Database: 6.2.1.15
///
ENTRY       EC 6.2.1.16
NAME        Acetoacetate--CoA ligase
            Acetoacetyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acetoacetate:CoA ligase (AMP-forming)
REACTION    ATP + Acetoacetate + CoA = AMP + Pyrophosphate + Acetoacetyl-CoA
SUBSTRATE   ATP
            Acetoacetate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Acetoacetyl-CoA
COMMENT     Also acts, more slowly, on L-3-hydroxybutanoate.
PATHWAY     PATH: MAP00650  Butanoate metabolism
GENES       MLO: mlr6539
            SME: SMc00774(acsA2)
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.16
            ExPASy - ENZYME nomenclature database: 6.2.1.16
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.16
            BRENDA, the Enzyme Database: 6.2.1.16
///
ENTRY       EC 6.2.1.17
NAME        Propionate--CoA ligase
            Propionyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Propanoate:CoA ligase (AMP-forming)
REACTION    ATP + Propanoate + CoA = AMP + Pyrophosphate + Propanoyl-CoA
SUBSTRATE   ATP
            Propanoate
            CoA
            Propenoate
PRODUCT     AMP
            Pyrophosphate
            Propanoyl-CoA
            Propenoyl-CoA
COMMENT     Propenoate can act instead of propanoate. Not identical with
            EC 6.2.1.1 or 6.2.1.2.
PATHWAY     PATH: MAP00640  Propanoate metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.17
            ExPASy - ENZYME nomenclature database: 6.2.1.17
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.17
            BRENDA, the Enzyme Database: 6.2.1.17
///
ENTRY       EC 6.2.1.18
NAME        Citrate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Citrate:CoA ligase (ADP-forming)
REACTION    ATP + Citrate + CoA = ADP + Orthophosphate + (3S)-Citryl-CoA
SUBSTRATE   ATP
            Citrate
            CoA
PRODUCT     ADP
            Orthophosphate
            (3S)-Citryl-CoA
COMMENT     The enzyme is a component of EC 4.1.3.8.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.18
            ExPASy - ENZYME nomenclature database: 6.2.1.18
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.18
            BRENDA, the Enzyme Database: 6.2.1.18
///
ENTRY       EC 6.2.1.19
NAME        Long-chain-fatty-acid--luciferin-component ligase
            Acyl-protein synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Long-chain-fatty-acid:protein ligase (AMP-forming)
REACTION    ATP + an Acid + Protein = AMP + Pyrophosphate +
            an Acyl-protein thiolester
SUBSTRATE   ATP
            Acid
            Protein
PRODUCT     AMP
            Pyrophosphate
            Acyl-protein thiolester
COMMENT     Together with EC 1.2.1.50 forms a fatty acid reductase system
            which produces the substrate of EC 1.14.14.3, thus being a
            component of the bacterial luciferase system.
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.19
            ExPASy - ENZYME nomenclature database: 6.2.1.19
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.19
            BRENDA, the Enzyme Database: 6.2.1.19
///
ENTRY       EC 6.2.1.20
NAME        Long-chain-fatty-acid--[acyl-carrier-protein] ligase
            Acyl-[acyl-carrier-protein] synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming)
REACTION    ATP + an Acid + [Acyl-carrier protein] = AMP + Pyrophosphate +
            Acyl-[acyl-carrier protein]
SUBSTRATE   ATP
            Acid
            Acyl-carrier protein
PRODUCT     AMP
            Pyrophosphate
            Acyl-[acyl-carrier protein]
COMMENT     Not identical with EC 6.2.1.3.
PATHWAY     PATH: MAP00071  Fatty acid metabolism
GENES       ECO: b2836(aas)
            ECE: Z4154(aas)
            ECS: ECs3693
            RPR: RP620(aas)
            MLO: mlr5451
            AAE: aq_2058(aas)
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.20
            ExPASy - ENZYME nomenclature database: 6.2.1.20
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.20
            BRENDA, the Enzyme Database: 6.2.1.20
///
ENTRY       EC 6.2.1.21
NAME        Phenylacetate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Phenylacetate:CoA ligase
REACTION    ATP + Phenylacetate + CoA = AMP + Pyrophosphate + Phenylacetyl-CoA;
            ATP + Phenylacetate + CoA = ADP + Orthophosphate + Phenylacetyl-CoA
SUBSTRATE   ATP
            Phenylacetate
            CoA
            Phenoxyacetate
PRODUCT     AMP
            Pyrophosphate
            ADP
            Orthophosphate
            Phenylacetyl-CoA
            Phenoxyacetyl-CoA
COMMENT     Phenoxyacetate can replace phenylacetate.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.21
            ExPASy - ENZYME nomenclature database: 6.2.1.21
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.21
            BRENDA, the Enzyme Database: 6.2.1.21
///
ENTRY       EC 6.2.1.22
NAME        Citrate (pro-3S)-lyase ligase
            Citrate lyase ligase
            Citrate lyase synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)
REACTION    ATP + Acetate + Citrate (pro-3S)-lyase (thiol form) = AMP +
            Pyrophosphate + Citrate (pro-3S)-lyase (acetyl form)
SUBSTRATE   ATP
            Acetate
            Citrate (pro-3S)-lyase (thiol form)
PRODUCT     AMP
            Pyrophosphate
            Citrate (pro-3S)-lyase (acetyl form)
COMMENT     Converts the inactive thiol form of EC 4.1.3.6 into the active
            form.
GENES       ECO: b0618(citC)
            ECE: Z0762(citC)
            ECS: ECs0657
            HIN: HI0025(citC)
            VCH: VC0796
            LLA: L0038(citC)
            SPY: SPy1192(citC)
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.22
            ExPASy - ENZYME nomenclature database: 6.2.1.22
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.22
            BRENDA, the Enzyme Database: 6.2.1.22
///
ENTRY       EC 6.2.1.23
NAME        Dicarboxylate--CoA ligase
            Carboxylyl-CoA synthetase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     omega-Dicarboxylate:CoA ligase (AMP-forming)
REACTION    ATP + an alpha(omega)-Dicarboxylic acid = AMP + Pyrophosphate +
            an omega-Carboxyacyl-CoA
SUBSTRATE   ATP
            alpha(omega)-Dicarboxylic acid
            Dodecanedioic acid
PRODUCT     AMP
            Pyrophosphate
            omega-Carboxyacyl-CoA
COMMENT     Acts on dicarboxylic acids of chain length C5 to C16; the best
            substrate is dodecanedioic acid.
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.23
            ExPASy - ENZYME nomenclature database: 6.2.1.23
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.23
            BRENDA, the Enzyme Database: 6.2.1.23
///
ENTRY       EC 6.2.1.24
NAME        Phytanate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Phytanate:CoA ligase (AMP-forming)
REACTION    ATP + Phytanate + CoA = AMP + Pyrophosphate + Phytanoyl-CoA
SUBSTRATE   ATP
            Phytanate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Phytanoyl-CoA
COMMENT     Not identical with EC 6.2.1.20.
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.24
            ExPASy - ENZYME nomenclature database: 6.2.1.24
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.24
            BRENDA, the Enzyme Database: 6.2.1.24
///
ENTRY       EC 6.2.1.25
NAME        Benzoate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Benzoate:CoA ligase (AMP-forming)
REACTION    ATP + Benzoate + CoA = AMP + Pyrophosphate + Benzoyl-CoA
SUBSTRATE   ATP
            Benzoate
            CoA
            2-Fluorobenzoate
            3-Fluorobenzoate
            4-Fluorobenzoate
PRODUCT     AMP
            Pyrophosphate
            Benzoyl-CoA
            2-Fluorobenzoyl-CoA
            3-Fluorobenzoyl-CoA
            4-Fluorobenzoyl-CoA
COMMENT     Also acts on 2-, 3- and 4- fluorobenzoate, but only very slowly
            on the corresponding chlorobenzoates.
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.25
            ExPASy - ENZYME nomenclature database: 6.2.1.25
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.25
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
            BRENDA, the Enzyme Database: 6.2.1.25
///
ENTRY       EC 6.2.1.26
NAME        O-Succinylbenzoate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     O-Succinylbenzoate:CoA ligase (AMP-forming)
REACTION    ATP + 2-Succinylbenzoate + CoA = AMP + Pyrophosphate +
            2-Succinylbenzoyl-CoA
SUBSTRATE   ATP
            2-Succinylbenzoate
            CoA
PRODUCT     AMP
            Pyrophosphate
            2-Succinylbenzoyl-CoA
PATHWAY     PATH: MAP00130  Ubiquinone biosynthesis
GENES       ECO: b2260(menE)
            ECE: Z3520(menE)
            ECS: ECs3148
            YPE: YPO2523(menE)
            HIN: HI0194(menE)
            PMU: PM0357(menE)
            VCH: VC1971
            BSU: BG10687(menE)
            SAU: SA1615(menE)
            SAV: SAV1783(menE)
            LLA: L0172(menE)
            MTU: Rv0542c(menE)
            MTC: MT0567
            MLE: ML2257(menE)
            SYN: slr0492(menE)
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.26
            ExPASy - ENZYME nomenclature database: 6.2.1.26
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.26
            BRENDA, the Enzyme Database: 6.2.1.26
///
ENTRY       EC 6.2.1.27
NAME        4-Hydroxybenzoate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     4-Hydroxybenzoate:CoA ligase (AMP-forming)
REACTION    ATP + 4-Hydroxybenzoate + CoA = AMP + Pyrophosphate +
            4-Hydroxybenzoyl-CoA
SUBSTRATE   ATP
            4-Hydroxybenzoate
            CoA
PRODUCT     AMP
            Pyrophosphate
            4-Hydroxybenzoyl-CoA
PATHWAY     PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.27
            ExPASy - ENZYME nomenclature database: 6.2.1.27
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.27
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.27
            BRENDA, the Enzyme Database: 6.2.1.27
///
ENTRY       EC 6.2.1.28
NAME        3alpha,7alpha-Dihydroxy-5beta-cholestanate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     3alpha,7alpha-Dihydroxy-5beta-cholestanate:CoA ligase
            $ (AMP-forming)
REACTION    ATP + 3alpha,7alpha-Dihydroxy-5beta-cholestanate + CoA = AMP +
            Pyrophosphate + 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
SUBSTRATE   ATP
            3alpha,7alpha-Dihydroxy-5beta-cholestanate
            CoA
PRODUCT     AMP
            Pyrophosphate
            3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.28
            ExPASy - ENZYME nomenclature database: 6.2.1.28
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.28
            BRENDA, the Enzyme Database: 6.2.1.28
///
ENTRY       EC 6.2.1.29
NAME        3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanate:CoA ligase
            $ (AMP-forming)
REACTION    ATP + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate + CoA =
            AMP + Pyrophosphate +
            3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA
SUBSTRATE   ATP
            3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
            CoA
PRODUCT     AMP
            Pyrophosphate
            3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA
COMMENT     Not identical with EC 6.2.1.3 or 6.2.1.7.
PATHWAY     PATH: MAP00120  Bile acid biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.29
            ExPASy - ENZYME nomenclature database: 6.2.1.29
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.29
            BRENDA, the Enzyme Database: 6.2.1.29
///
ENTRY       EC 6.2.1.30
NAME        Phenylacetate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Phenylacetate:CoA ligase (AMP-forming)
REACTION    ATP + Phenylacetate + CoA = AMP + Pyrophosphate + Phenylacetyl-CoA
SUBSTRATE   ATP
            Phenylacetate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Phenylacetyl-CoA
COMMENT     Also acts, more slowly, on acetate, propanoate and butanoate, but
            not on hydroxy derivatives of phenylacetate and related compounds.
PATHWAY     PATH: MAP00350  Tyrosine metabolism
            PATH: MAP00360  Phenylalanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.30
            ExPASy - ENZYME nomenclature database: 6.2.1.30
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.30
            BRENDA, the Enzyme Database: 6.2.1.30
///
ENTRY       EC 6.2.1.31
NAME        2-Furoate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     2-Furoate:CoA ligase (AMP-forming)
REACTION    ATP + 2-Furoate + CoA = AMP + Pyrophosphate + 2-Furoyl-CoA
SUBSTRATE   ATP
            2-Furoate
            CoA
PRODUCT     AMP
            Pyrophosphate
            2-Furoyl-CoA
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.31
            ExPASy - ENZYME nomenclature database: 6.2.1.31
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.31
            BRENDA, the Enzyme Database: 6.2.1.31
///
ENTRY       EC 6.2.1.32
NAME        Anthranilate--CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
SYSNAME     Anthranilate:CoA ligase (AMP-forming)
REACTION    ATP + Anthranilate + CoA = AMP + Pyrophosphate + Anthranilyl-CoA
SUBSTRATE   ATP
            Anthranilate
            CoA
PRODUCT     AMP
            Pyrophosphate
            Anthranilyl-CoA
PATHWAY     PATH: MAP00629  Carbazole degradation
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.32
            ExPASy - ENZYME nomenclature database: 6.2.1.32
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.32
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.32
            BRENDA, the Enzyme Database: 6.2.1.32
///
ENTRY       EC 6.2.1.33
NAME        4-Chlorobenzoate-CoA ligase
CLASS       Ligases
            Forming carbon-sulfur bonds
            Acid--thiol ligases
REACTION    4-Chlorobenzoate + CoA + ATP = 4-Chlorobenzoyl-CoA + AMP +
            Diphosphate
SUBSTRATE   4-Chlorobenzoate
            CoA
            ATP
PRODUCT     4-Chlorobenzoyl-CoA
            AMP
            Diphosphate
COFACTOR    Magnesium
COMMENT     Part of the bacterial 2,4-dichlorobenzoate degradation pathway.
PATHWAY     PATH: MAP00623  2,4-Dichlorobenzoate degradation
DBLINKS     IUBMB Enzyme Nomenclature: 6.2.1.33
            ExPASy - ENZYME nomenclature database: 6.2.1.33
            WIT (What Is There) Metabolic Reconstruction: 6.2.1.33
            UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.33
///
ENTRY       EC 6.3.1.1
NAME        Aspartate--ammonia ligase
            Asparagine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     L-Asparagine:ammonia ligase (AMP-forming)
REACTION    ATP + L-Aspartate + NH3 = AMP + Pyrophosphate + L-Asparagine
SUBSTRATE   ATP
            L-Aspartate
            NH3
PRODUCT     AMP
            Pyrophosphate
            L-Asparagine
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00460  Cyanoamino acid metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b3744(asnA)
            ECE: Z5245(asnA)
            ECS: ECs4686
            YPE: YPO0003(asnA)
            HIN: HI0564(asnA)
            PMU: PM1574(asnA)
            SPY: SPy1539(asnA)
            SPN: SP1970
            SPR: spr1785(asnA)
            UUR: UU363(asnA)
            TPA: TP0556
STRUCTURES  PDB: 11AS  12AS  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.1
            ExPASy - ENZYME nomenclature database: 6.3.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.1
            BRENDA, the Enzyme Database: 6.3.1.1
            SCOP (Structural Classification of Proteins): 6.3.1.1
///
ENTRY       EC 6.3.1.2
NAME        Glutamate--ammonia ligase
            Glutamine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     L-Glutamate:ammonia ligase (ADP-forming)
REACTION    ATP + L-Glutamate + NH3 = ADP + Orthophosphate + L-Glutamine
SUBSTRATE   ATP
            L-Glutamate
            NH3
            4-Methylene-L-glutamate
PRODUCT     ADP
            Orthophosphate
            L-Glutamine
INHIBITOR   L-Methionine sulfoximine
            L-2-Amino-4-(hydroxymethylphosphinyl)butanoate
            2S,5S-Methionine sulfoximine
            3-(Phosphoacetylamido)-L-alanine
COMMENT     Also acts, more slowly, on 4-methylene-L-glutamate (cf.
            EC 6.3.1.7).
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b1297 b3870(glnA)
            ECE: Z2491 Z5406(glnA)
            ECS: ECs1874 ECs4792
            YPE: YPO0024(glnA)
            HIN: HI0865(glnA)
            PMU: PM1175(glnA)
            XFA: XF1842
            VCH: VC2746
            PAE: PA0296 PA0298 PA1566 PA2040 PA5119(glnA) PA5522
            NME: NMB0359
            NMA: NMA2128(glnA)
            HPY: HP0512(glnA)
            HPJ: jhp0461
            CJE: Cj0699c(glnA)
            MLO: mll0343 mll3074 mll4187 mll5148 mll6521 mll7254 mll7307
                 mlr0339 mlr6210
            SME: SMb20745(glnII) SMc00762 SMc00948(glnA) SMc02352
                 SMc02613(glnT)
            ATU: AGR_L_1262
            CCR: CC1969 CC3130 CC3138
            BSU: BG10425(glnA)
            BHA: BH2360(glnA) BH3867
            SAU: SA1150(glnA)
            SAV: SAV1296(glnA)
            LLA: L0118(glnA)
            SPY: SPy1877(glnA)
            SPN: SP0502
            SPR: spr0444(glnA)
            CAC: CAC2658(glnA)
            MTU: Rv2220(glnA1) Rv2222c(glnA2) Rv2860c(glnA4)
            MTC: MT2278 MT2280 MT2928
            MLE: ML0925(glnA) ML1631(glnA2)
            SYN: slr0288(glnN) slr1756(glnA)
            DRA: DR0451 DR2033
            AAE: aq_111(glnA)
            TMA: TM0943
            MJA: MJ1346(glnA)
            MTH: MTH1570
            AFU: AF0949(glnA)
            HAL: VNG2093G(glnA)
            TAC: Ta1498
            TVO: TVG1571797
            PHO: PH0359
            PAB: PAB1292(glnA)
            APE: APE2142
            SSO: SSO0366(glnA-1) SSO2440(glnA-2) SSO2554(glnA-3)
            STO: ST0156 ST0568
            SCE: YPR035W(GLN1)
            SPO: GLN1(gln1)
            CEL: C28D4.3 F26D10.10 K03H1.1
            DME: CG1743(Gs2) CG2718(Gs1)
            MMU: 95740(Glns-ps1)
            HSA: 2752(GLUL)
DISEASE     MIM: 138290  Glutamate-ammonia ligase (glutamine synthase)
MOTIF       PS: PS00180  [FYWL]-D-G-S-S-x(6,8)-[DENQSTAK]-[SA]-[DE]-x(2)-
                         [LIVMFY]
            PS: PS00181  K-P-[LIVMFYA]-x(3,5)-[NPAT]-G-[GSTAN]-G-x-H-x(3)-S
            PS: PS00182  K-[LIVM]-x(5)-[LIVMA]-D-[RK]-[DN]-[LI]-Y
STRUCTURES  PDB: 1F1H  1F52  1FPY  1LGR  2GLS  2LGS  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.2
            ExPASy - ENZYME nomenclature database: 6.3.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.2
            BRENDA, the Enzyme Database: 6.3.1.2
            SCOP (Structural Classification of Proteins): 6.3.1.2
///
ENTRY       EC 6.3.1.3
NAME        Transferred to EC 6.3.4.13
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
COMMENT     Transferred entry. Now EC 6.3.4.13 - Phosphoribosylamine--glycine
            ligase.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.3
            ExPASy - ENZYME nomenclature database: 6.3.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.3
///
ENTRY       EC 6.3.1.4
NAME        Aspartate--ammonia ligase (ADP-forming)
            Asparagine synthetase (ADP-forming)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     L-Aspartate:ammonia ligase (ADP-forming)
REACTION    ATP + L-Aspartate + NH3 = ADP + Orthophosphate + L-Asparagine
SUBSTRATE   ATP
            L-Aspartate
            NH3
PRODUCT     ADP
            Orthophosphate
            L-Asparagine
PATHWAY     PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.4
            ExPASy - ENZYME nomenclature database: 6.3.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.4
            BRENDA, the Enzyme Database: 6.3.1.4
///
ENTRY       EC 6.3.1.5
NAME        NAD+ synthase
            NAD+ synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     Deamino-NAD+:ammonia ligase (AMP-forming)
REACTION    ATP + Deamino-NAD+ + NH3 = AMP + Pyrophosphate + NAD+
SUBSTRATE   ATP
            Deamino-NAD+
            NH3
PRODUCT     AMP
            Pyrophosphate
            NAD+
COMMENT     L-Glutamine also acts, more slowly, as amido-donor (cf.
            EC 6.3.5.1).
PATHWAY     PATH: MAP00760  Nicotinate and nicotinamide metabolism
            PATH: MAP00910  Nitrogen metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.5
            ExPASy - ENZYME nomenclature database: 6.3.1.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.5
            BRENDA, the Enzyme Database: 6.3.1.5
///
ENTRY       EC 6.3.1.6
NAME        Glutamate--ethylamine ligase
            N5-ethyl-L-glutamine synthetase
            Theanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     L-Glutamate:ethylamine ligase (ADP-forming)
REACTION    ATP + L-Glutamate + Ethylamine = ADP + Orthophosphate +
            N5-Ethyl-L-glutamine
SUBSTRATE   ATP
            L-Glutamate
            Ethylamine
PRODUCT     ADP
            Orthophosphate
            N5-Ethyl-L-glutamine
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.6
            ExPASy - ENZYME nomenclature database: 6.3.1.6
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.6
            BRENDA, the Enzyme Database: 6.3.1.6
///
ENTRY       EC 6.3.1.7
NAME        4-Methyleneglutamate--ammonia ligase
            4-Methyleneglutamine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
SYSNAME     4-Methylene-L-glutamate:ammonia ligase (AMP-forming)
REACTION    ATP + 4-Methylene-L-glutamate + NH3 = AMP + Pyrophosphate +
            4-Methylene-L-glutamine
SUBSTRATE   ATP
            4-Methylene-L-glutamate
            NH3
PRODUCT     AMP
            Pyrophosphate
            4-Methylene-L-glutamine
COMMENT     Glutamine can act instead of NH3, more slowly.
PATHWAY     PATH: MAP00660  C5-Branched dibasic acid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.7
            ExPASy - ENZYME nomenclature database: 6.3.1.7
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.7
            BRENDA, the Enzyme Database: 6.3.1.7
///
ENTRY       EC 6.3.1.8
NAME        Glutathionylspermidine synthase
            Glutathionylspermidine synthetase
            GSP synthetase
            Glutathione:spermidine ligase (ADP-forming)
            Gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP
            $ forming)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
REACTION    gamma-L-Glutamyl-L-cysteinyl-glycine + Spermidine + ATP =
            N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine + ADP +
            Phosphate
SUBSTRATE   gamma-L-Glutamyl-L-cysteinyl-glycine
            Spermidine
            ATP
PRODUCT     N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine
            ADP
            Phosphate
COFACTOR    Magnesium
COMMENT     Transforms glutathione and spermidine into glutathionylspermidine.
            Involved in the synthesis of trypanothione in trypanosomatids.
            The enzyme from E.coli is bifunctional and also catalyses the
            glutathionylspermidine amidase (EC 3.5.1.78) reaction, resulting in
            a net hydrolysis of ATP.
PATHWAY     PATH: MAP00480  Glutathione metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.8
            ExPASy - ENZYME nomenclature database: 6.3.1.8
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.8
///
ENTRY       EC 6.3.1.9
NAME        Trypanothione synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--ammonia (or amine) ligases (amide synthases)
REACTION    gamma-L-Glutamyl-L-cysteinyl-glycine +
            N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine + ATP =
            N1,N8-Bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP +
            Phosphate
SUBSTRATE   gamma-L-Glutamyl-L-cysteinyl-glycine
            N1-(gamma-L-Glutamyl-L-cysteinyl-glycyl)-spermidine
            ATP
PRODUCT     N1,N8-Bis-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine
            ADP
            Phosphate
COMMENT     Glutathione + glutathionylspermidine + ATP = N1,N8-bis-
            (glutathionyl)spermidine + ADP + phosphate.
            Involved in the synthesis of trypanothione in trypanosomatids.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.1.9
            ExPASy - ENZYME nomenclature database: 6.3.1.9
            WIT (What Is There) Metabolic Reconstruction: 6.3.1.9
///
ENTRY       EC 6.3.2.1
NAME        Pantoate--beta-alanine ligase
            Pantothenate synthetase
            Pantoate activating enzyme
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     (R)-Pantoate:beta-alanine ligase (AMP-forming)
REACTION    ATP + (R)-Pantoate + beta-Alanine = AMP + Pyrophosphate +
            (R)-Pantothenate
SUBSTRATE   ATP
            (R)-Pantoate
            beta-Alanine
PRODUCT     AMP
            Pyrophosphate
            (R)-Pantothenate
PATHWAY     PATH: MAP00410  beta-Alanine metabolism
            PATH: MAP00770  Pantothenate and CoA biosynthesis
GENES       ECO: b0133(panC)
            ECE: Z0144(panC)
            ECS: ECs0137
            YPE: YPO3402(panC)
            XFA: XF0230 XF2443
            VCH: VC0591
            PAE: PA4730
            BUC: BU196(panC)
            NME: NMB0871
            NMA: NMA1089(panC)
            HPY: HP0006(panC) HP0757
            HPJ: jhp0006 jhp0694
            CJE: Cj0297c(panC)
            MLO: mll0196
            SME: SMc01880(panC)
            CCR: CC2166
            BSU: BG11520(panC)
            BHA: BH1688(panC)
            SAU: SA2391(panC)
            SAV: SAV2582(panC)
            CAC: CAC2915(panC)
            MTU: Rv3602c(panC)
            MTC: MT3707
            MLE: ML0230(panC)
            SYN: sll1249(panC)
            DRA: DR1164
            AAE: aq_2132(panC)
            TMA: TM1077
            SCE: YIL145C(YIL145C)
            SPO: SPAC5H10.08C(spac5h10.08c)
            ATH: At5g48840(K24G6.18)
STRUCTURES  PDB: 1IHO  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.1
            ExPASy - ENZYME nomenclature database: 6.3.2.1
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.1
            BRENDA, the Enzyme Database: 6.3.2.1
///
ENTRY       EC 6.3.2.2
NAME        Glutamate--cysteine ligase
            gamma-Glutamylcysteine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     L-Glutamate:L-cysteine gamma-ligase (ADP-forming)
REACTION    ATP + L-Glutamate + L-Cysteine = ADP + Orthophosphate +
            gamma-L-Glutamyl-L-cysteine
SUBSTRATE   ATP
            L-Glutamate
            L-Cysteine
            L-Aminohexanoate
PRODUCT     ADP
            Orthophosphate
            gamma-L-Glutamyl-L-cysteine
INHIBITOR   S-Butyl-DL-homocysteine-[S,R]-sulfoximine
COMMENT     Can use L-aminohexanoate in place of glutamate.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
GENES       ECO: b2688(gshA)
            ECE: Z3989(gshA)
            YPE: YPO3301(gshA)
            XFA: XF1428
            VCH: VC0556
            PAE: PA5203(gshA)
            BUC: BU407(gshA)
            NME: NMB1037
            NMA: NMA1449(gshA)
            MLO: mll6902
            SME: SMc00825(gsh1)
            CCR: CC3414
            CAC: CAC1539
            SCE: YJL101C(GSH1)
            SPO: GCS1(gcs1)
            ATH: At4g23100(F7H19.290)
            CEL: F37B12.2
            DME: CG2259
            MMU: 104990(Glclc) 104995(Glclr)
            HSA: 2729(GCLC) 2730(GCLM)
DISEASE     MIM: 230450  Glutamate-cysteine ligase (gamma-glutamylcysteine
                         synthetase),
            MIM: 601176  Glutamate-cysteine ligase (gamma-glutamylcysteine
                         synthetase),
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.2
            ExPASy - ENZYME nomenclature database: 6.3.2.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.2
            BRENDA, the Enzyme Database: 6.3.2.2
///
ENTRY       EC 6.3.2.3
NAME        Glutathione synthase
            Glutathione synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     gamma-L-Glutamyl-L-cysteine:glycine ligase (ADP-forming)
REACTION    ATP + gamma-L-Glutamyl-L-cysteine + Glycine = ADP + Orthophosphate
            + Glutathione
SUBSTRATE   ATP
            gamma-L-Glutamyl-L-cysteine
            Glycine
PRODUCT     ADP
            Orthophosphate
            Glutathione
INHIBITOR   Phosphinate
COMMENT     Transition-state analog inhibitor phosphinate (J.Amer.Chem.Soc.,
            1994, 116, 12059-12060). Structure is similar to D-alanine-D-
            -alanine ligase (EC 6.3.2.4) from E. coli; Proc.Natl.Acad.Sci.USA,
            1995, 92, 1172-1176. Evolved from a common ancestor.
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00480  Glutathione metabolism
GENES       ECO: b2947(gshB)
            ECE: Z4292(gshB)
            ECS: ECs3823
            YPE: YPO0935(gshB)
            XFA: XF1956
            VCH: VC0468
            PAE: PA0407(gshB)
            BUC: BU547(gshB)
            NME: NMB1559
            NMA: NMA1747(gshB)
            MLO: mll4735
            SME: SMb21586(gshB2) SMc00419(gshB1)
            CCR: CC0141
            SYN: slr1238(gshB)
            SCE: YOL049W(GSH2)
            SPO: GSA1(gsa1)
            CEL: M176.2
            HSA: 2937(GSS)
DISEASE     MIM: 601002  Glutathione synthetase
STRUCTURES  PDB: 1GLV  1GSA  2HGS  2GLT  1GSH  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.3
            ExPASy - ENZYME nomenclature database: 6.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.3
            BRENDA, the Enzyme Database: 6.3.2.3
            SCOP (Structural Classification of Proteins): 6.3.2.3
///
ENTRY       EC 6.3.2.4
NAME        D-Alanine-D-alanine ligase
            Alanylalanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Alanine:alanine ligase (ADP-forming)
REACTION    ATP + Alanine + Alanine = ADP + Orthophosphate +
            D-Alanyl-D-alanine
SUBSTRATE   ATP
            Alanine
PRODUCT     ADP
            Orthophosphate
            D-Alanyl-D-alanine
INHIBITOR   Phosphinate
COMMENT     Transition-state analog inhibitor phosphinate (Science, 1994, 266,
            439-443).  Structure is similar to glutathione synthase
            (EC 6.3.2.3) from E. coli; Proc. Natl.Acad.Sci.USA, 1995, 92,
            1172-1176. Evolved from a common ancestor.
PATHWAY     PATH: MAP00473  D-Alanine metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
            PATH: MAP00561  Glycerolipid metabolism
GENES       ECO: b0092(ddlB) b0381(ddlA)
            ECE: Z0102(ddlB) Z0477
            ECS: ECs0096 ECs0431
            YPE: YPO0557(ddlB)
            HIN: HI1140(ddlB)
            PMU: PM0144(ddlB)
            XFA: XF0799
            VCH: VCA0572
            PAE: PA4201(ddlA) PA4410(ddlB)
            NME: NMB0424
            NMA: NMA2060(ddlB)
            HPY: HP0738(ddl)
            HPJ: jhp0675
            CJE: Cj0798c(ddlA)
            RPR: RP249(ddlB)
            RCO: RC0333(ddlB)
            MLO: mll1551 mll1812
            SME: SMc01871(ddlB)
            CCR: CC2543
            BSU: BG11932(ddlA)
            BHA: BH1621(ddlA)
            SAU: SA1887(ddlA)
            SAV: SAV2068
            LLA: L140690(ddl)
            SPY: SPy1421(ddlA)
            SPN: SP1671
            SPR: spr1515(ddl)
            CAC: CAC2895(ddlA)
            MTU: Rv2981c(ddlA)
            MTC: MT3059
            MLE: ML1678(ddlA)
            CTR: CT762
            CMU: TC0143
            CPN: CPn0905
            CPA: CP0961
            CPJ: murC_ddlA
            BBU: BB0200(ddlA)
            TPA: TP0670
            SYN: slr1874(ddlA)
            DRA: DR0362
            AAE: aq_521(ddlA)
            TMA: TM0259
MOTIF       PS: PS00843  H-G-x(2)-G-E-D-G-x-[LIVMA]-[QSA]-[GSA]
            PS: PS00844  [LIV]-x(3)-[GA]-x-[GSAIV]-R-[LIVMCA]-D-[LIVMFA](2)-
                         x(7,9)-[LIV]-x-E-[LIVAP]-N-[STP]-x-P-[GA]
STRUCTURES  PDB: 1IOW  1IOV  1EHI  2DLN  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.4
            ExPASy - ENZYME nomenclature database: 6.3.2.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.4
            BRENDA, the Enzyme Database: 6.3.2.4
            SCOP (Structural Classification of Proteins): 6.3.2.4
///
ENTRY       EC 6.3.2.5
NAME        Phosphopantothenate--cysteine ligase
            Phosphopantothenoylcysteine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     (R)-4'-Phosphopantothenate:L-cysteine ligase
REACTION    CTP + (R)-4'-Phosphopantothenate + L-Cysteine = CDP + 
            Orthophosphate + (R)-4'-Phosphopantothenoyl-L-cysteine;
            CTP + (R)-4'-Phosphopantothenate + L-Cysteine = CMP + 
            Pyrophosphate + (R)-4'-Phosphopantothenoyl-L-cysteine
SUBSTRATE   CTP
            (R)-4'-Phosphopantothenate
            L-Cysteine
PRODUCT     CDP
            Orthophosphate
            (R)-4'-Phosphopantothenoyl-L-cysteine
            CMP
            Pyrophosphate
COMMENT     Cysteine can be replaced by some of its derivatives.
PATHWAY     PATH: MAP00770  Pantothenate and CoA biosynthesis
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.5
            ExPASy - ENZYME nomenclature database: 6.3.2.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.5
            BRENDA, the Enzyme Database: 6.3.2.5
///
ENTRY       EC 6.3.2.6
NAME        Phosphoribosylaminoimidazolesuccinocarboxyamide synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase
            (ADP-forming)
REACTION    ATP + 1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole +
            L-Aspartate = ADP + Orthophosphate +
            1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
SUBSTRATE   ATP
            1-(5'-Phosphoribosyl)-5-amino-4-carboxyimidazole
            L-Aspartate
PRODUCT     ADP
            Orthophosphate
            1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2476(purC)
            ECE: Z3735(purC)
            ECS: ECs3338
            YPE: YPO3059(purC)
            HIN: HI1726(purC)
            PMU: PM0815(purC)
            XFA: XF0205
            VCH: VC1190
            PAE: PA1013(purC)
            NME: NMB0757
            NMA: NMA0968(purC)
            CJE: Cj0512(purC)
            RPR: RP220(purC)
            RCO: RC0294(purC)
            MLO: mll0069
            SME: SMc00495(purC)
            CCR: CC2491
            BSU: BG10703(purC)
            BHA: BH0626(purC)
            SAU: SA0918(purC)
            SAV: SAV1052(purC)
            LLA: L177350(purC)
            SPY: SPy0024(purC)
            SPR: spr0045(purC)
            CAC: CAC1391(purC)
            MTU: Rv0780(purC)
            MTC: MT0804
            MLE: ML2227(purC)
            SYN: slr1226(purC)
            DRA: DR0226
            AAE: aq_2117(purC)
            TMA: TM1243
            MJA: MJ1592(purC)
            MTH: MTH170
            AFU: AF1272(purC)
            HAL: VNG1939G(purC)
            TAC: Ta0309
            TVO: TVG1355049
            PHO: PH0239
            PAB: PAB2400(purC)
            SSO: SSO0626(purC)
            SCE: YAR015W(ADE1)
            SPO: SPBC409.10(spbc409.10)
            CEL: B0286.3
            DME: CG17024
            HSA: 10606(ADE2H1) 5059(PAICS)
DISEASE     MIM: 172439  Phosphoribosylaminoimidazole carboxylase
MOTIF       PS: PS01057  [LIVMR]-[LIVFY]-P-[LIVM]-E-x-[IV]-[LVCAT]-R-x(3)-[TA]-
                         G-S
            PS: PS01058  [LI]-[IVCAP]-D-x-K-[LIFY]-E-[FI]-G
STRUCTURES  PDB: 1A48  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.6
            ExPASy - ENZYME nomenclature database: 6.3.2.6
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.6
            BRENDA, the Enzyme Database: 6.3.2.6
            SCOP (Structural Classification of Proteins): 6.3.2.6
///
ENTRY       EC 6.3.2.7
NAME        UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine ligase
            $ (ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-Lysine =
            ADP + Orthophosphate +
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
            L-Lysine
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
COMMENT     Involved with EC 6.3.2.4 and 6.3.2.7-10 in the synthesis of a
            cell-wall peptide.
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
GENES       SPR: spr1384(murE)
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.7
            ExPASy - ENZYME nomenclature database: 6.3.2.7
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.7
            BRENDA, the Enzyme Database: 6.3.2.7
///
ENTRY       EC 6.3.2.8
NAME        UDP-N-acetylmuramate--alanine ligase
            UDP-N-acetylmuramoyl-L-alanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)
REACTION    ATP + UDP-N-acetylmuramate + L-Alanine = ADP + Orthophosphate +
            UDP-N-acetylmuramoyl-L-alanine
SUBSTRATE   ATP
            UDP-N-acetylmuramate
            L-Alanine
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanine
COMMENT     Involved with EC 6.3.2.4, 6.3.2.7 and 6.3.2.9-10 in the
            synthesis of a cell-wall peptide.
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0091(murC)
            ECE: Z0101(murC)
            ECS: ECs0095
            YPE: YPO0556(murC)
            HIN: HI1139(murC)
            PMU: PM0143(murC)
            XFA: XF0798
            VCH: VC2400
            PAE: PA4411(murC)
            BUC: BU215(murC)
            NME: NMB0423
            NMA: NMA2061(murC)
            HPY: HP0623(murC)
            HPJ: jhp0567
            CJE: Cj1054c(murC)
            RPR: RP247(murC)
            RCO: RC0331(murC)
            MLO: mll1553
            SME: SMc01867(murC)
            CCR: CC2546
            BSU: BG10973(murC)
            BHA: BH3248(murC)
            SAU: SA1561(murC)
            SAV: SAV1727(murC)
            LLA: L101678(murC)
            SPY: SPy0345(murC)
            SPN: SP1521
            SPR: spr1373(murC)
            CAC: CAC3225(murC)
            MTU: Rv2152c(murC)
            MTC: MT2211
            MLE: ML0915(murC)
            CTR: CT762
            CMU: TC0143
            CPN: CPn0905
            CPA: CP0961
            CPJ: murC_ddlA
            BBU: BB0817(murC)
            TPA: TP0341
            SYN: slr1423(murC)
            DRA: DR0627
            AAE: aq_1360(murC)
            TMA: TM0231
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.8
            ExPASy - ENZYME nomenclature database: 6.3.2.8
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.8
            BRENDA, the Enzyme Database: 6.3.2.8
///
ENTRY       EC 6.3.2.9
NAME        UDP-N-acetylmuramoylalanine--D-glutamate ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanine:glutamate ligase(ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanine + Glutamate =
            ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanine
            Glutamate
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
COMMENT     Involved with EC 6.3.2.4, 6.3.2.7-8 and 6.3.2.10 in the
            synthesis of a cell-wall peptide.
PATHWAY     PATH: MAP00471  D-Glutamine and D-glutamate metabolism
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0088(murD)
            ECE: Z0098(murD)
            ECS: ECs0092
            YPE: YPO0553(murD)
            HIN: HI1136(murD)
            PMU: PM0140(murD)
            XFA: XF1118
            VCH: VC2403
            PAE: PA4414(murD)
            BUC: BU218(murD)
            NME: NMB0420
            NMA: NMA2064(murD)
            HPY: HP0494(murD)
            HPJ: jhp0446
            CJE: Cj0432c(murD)
            RPR: RP410(murD)
            RCO: RC0560(murD)
            MLO: mll1557
            SME: SMc01864(murD)
            CCR: CC2556
            BSU: BG10225(murD)
            BHA: BH2567(murD)
            SAU: SA1026(murD)
            SAV: SAV1170(murD)
            LLA: L0237(murD)
            SPY: SPy1525(murD)
            SPN: SP0688
            SPR: spr0603(murD)
            CAC: CAC3194(murD)
            MTU: Rv2155c(murD)
            MTC: MT2214
            MLE: ML0912(murD)
            CTR: CT758
            CMU: TC0139
            CPN: CPn0901
            CPA: CP0965
            CPJ: murD
            BBU: BB0585(murD)
            TPA: TP0903
            SYN: sll2010(murD)
            DRA: DR2496
            AAE: aq_2075(murD)
            TMA: TM0234
STRUCTURES  PDB: 3UAG  2UAG  1UAG  1EEH  1E0D  4UAG  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.9
            ExPASy - ENZYME nomenclature database: 6.3.2.9
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.9
            BRENDA, the Enzyme Database: 6.3.2.9
            SCOP (Structural Classification of Proteins): 6.3.2.9
///
ENTRY       EC 6.3.2.10
NAME        UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine--
            $D-alanyl-D-alanine ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-
            $D-alanyl-D-alanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:
            $alanyl-D-alanine ligase (ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine +
            D-Alanyl-D-alanine = ADP + Orthophosphate + UDP-N-acetylmuramoyl-
            $L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
            D-Alanyl-D-alanine
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
COMMENT     Involved with EC 6.3.2.4 and 6.3.2.7-9 in the synthesis of a
            cell-wall peptide.
PATHWAY     PATH: MAP00550  Peptideglycan biosynthesis
GENES       SPR: spr1514(murF)
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.10
            ExPASy - ENZYME nomenclature database: 6.3.2.10
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.10
            BRENDA, the Enzyme Database: 6.3.2.10
///
ENTRY       EC 6.3.2.11
NAME        Carnosine synthase
            Carnosine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     L-Histidine:beta-alanine ligase (AMP-forming)
REACTION    ATP + L-Histidine + beta-Alanine = AMP + Pyrophosphate + Carnosine
SUBSTRATE   ATP
            L-Histidine
            beta-Alanine
PRODUCT     AMP
            Pyrophosphate
            Carnosine
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.11
            ExPASy - ENZYME nomenclature database: 6.3.2.11
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.11
            BRENDA, the Enzyme Database: 6.3.2.11
///
ENTRY       EC 6.3.2.12
NAME        Dihydrofolate synthase
            Dihydrofolate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Dihydropteroate:L-glutamate ligase (ADP-forming)
REACTION    ATP + Dihydropteroate + L-Glutamate = ADP + Orthophosphate +
            Dihydrofolate
SUBSTRATE   ATP
            Dihydropteroate
            L-Glutamate
PRODUCT     ADP
            Orthophosphate
            Dihydrofolate
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2315(folC)
            ECE: Z3577(folC)
            ECS: ECs3199
            PMU: PM0635(folC)
            XFA: XF1946
            VCH: VC1001
            PAE: PA3111(folC)
            BUC: BU167(folC)
            NME: NMB0693
            NMA: NMA0896(folC)
            HPY: HP1545(folC)
            HPJ: jhp1454
            CJE: Cj1088c(folC)
            RPR: RP536(folC)
            MLO: mlr5076
            SME: SMc02763(folC)
            CCR: CC3541(folC)
            SPY: SPy0814(folC.2) SPy1096(folC.1)
            SPN: SP0197 SP0290
            SPR: spr0178(folC) spr0267(sulB)
            MTU: Rv2447c(folC)
            MTC: MT2523
            MLE: ML1471(folC)
            TPA: TP0340
            SYN: sll1612(folC)
            DRA: DR0340
            AAE: aq_2045(folC)
            TMA: TM0166
            HAL: VNG0412G(folP)
            TAC: Ta0637
            TVO: TVG0771612
MOTIF       PS: PS01011  [LIVMFY]-x-[LIVM]-[STAG]-G-T-[NK]-G-K-x-[ST]-x(7)-
                         [LIVM](2)-x(3)-[GSK]
            PS: PS01012  [LIVMFY](2)-E-x-G-[LIVM]-[GA]-G-x(2)-D-x-[GST]-x-
                         [LIVM](2)
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.12
            ExPASy - ENZYME nomenclature database: 6.3.2.12
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.12
            BRENDA, the Enzyme Database: 6.3.2.12
///
ENTRY       EC 6.3.2.13
NAME        UDP-N-acetylmuramoylalnyl-D-glutamate--2,6-diaminopimelate ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diamino
            $pimelate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino
            $heptanedioate ligase (ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate +
            meso-2,6-Diaminoheptanedioate =
            ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-D-
            $gamma-glutamyl-meso-2,6-diaminoheptanedioate
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
            meso-2,6-Diaminoheptanedioate
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-
            $diaminoheptanedioate
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0085(murE)
            ECE: Z0095(murE)
            ECS: ECs0089
            YPE: YPO0550(murE)
            HIN: HI1133(murE)
            PMU: PM0137(murE)
            XFA: XF0793
            VCH: VC2406
            PAE: PA4417(murE)
            BUC: BU221(murE)
            NME: NMB0414
            NMA: NMA2071(murE)
            HPY: HP1494(murE)
            HPJ: jhp1387
            CJE: Cj1641(murE)
            RPR: RP597(murE)
            RCO: RC0912(murE)
            MLO: mll1560
            SME: SMc01861(murE)
            CCR: CC2559
            BSU: BG10223(murE)
            BHA: BH2571(murE)
            SAU: SA0876(murE)
            SAV: SAV1003(murE)
            LLA: L53929(murE)
            SPY: SPy0388(murE)
            SPN: SP1530
            CAC: CAC2129(murE) CAC2819(murE)
            MTU: Rv2158c(murE)
            MTC: MT2217
            MLE: ML0909(murE)
            CTR: CT269
            CMU: TC0540
            CPN: CPn0418
            CPA: CP0336
            CPJ: murE
            BBU: BB0201(murE)
            TPA: TP0933
            SYN: slr0528(murE)
            DRA: DR0297
            AAE: aq_1747(murE)
            TMA: TM0237
            MTH: MTH530 MTH531 MTH532
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.13
            ExPASy - ENZYME nomenclature database: 6.3.2.13
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.13
            BRENDA, the Enzyme Database: 6.3.2.13
///
ENTRY       EC 6.3.2.14
NAME        2,3-Dihydroxybenzoate--serine ligase
            N-(2,3-Dihydroxybenzoyl)-serine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     2,3-Dihydroxybenzoate:L-serine ligase
REACTION    ATP + 2,3-Dihydroxybenzoate + L-Serine = ADP or AMP + 
            N-(2,3-Dihydroxybenzoyl)-L-serine
SUBSTRATE   ATP
            2,3-Dihydroxybenzoate
            L-Serine
PRODUCT     ADP
            AMP
            N-(2,3-Dihydroxybenzoyl)-L-serine
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.14
            ExPASy - ENZYME nomenclature database: 6.3.2.14
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.14
            BRENDA, the Enzyme Database: 6.3.2.14
///
ENTRY       EC 6.3.2.15
NAME        UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-
            $diaminopimelate-D-alanyl-D-alanine ligase
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminopimeloyl-D-alanyl-D-alanine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate:D-alanyl-D-alanine ligase(ADP-forming)
REACTION    ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate + D-Alanyl-D-alanine = ADP + Orthophosphate
            + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanyl-D-alanine
SUBSTRATE   ATP
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-
            $diaminoheptanedioate
            D-Alanyl-D-alanine
PRODUCT     ADP
            Orthophosphate
            UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-
            $carboxy-L-lysyl-D-alanyl-D-alanine
COMMENT     The enzyme from Bacillus subtillis also catalyses the reverse,
            hydrolytic, reaction in the presence of ADP, orthophosphate and
            Co2+. No formation of ATP, however, was observed.
PATHWAY     PATH: MAP00300  Lysine biosynthesis
            PATH: MAP00550  Peptideglycan biosynthesis
GENES       ECO: b0086(murF)
            ECE: Z0096(murF)
            ECS: ECs0090
            YPE: YPO0551(murF)
            HIN: HI1134(murF)
            PMU: PM0138(murF)
            XFA: XF0794
            VCH: VC2405
            PAE: PA4416(murF)
            BUC: BU220(murF)
            NME: NMB0416
            NMA: NMA2068(murF)
            HPY: HP0740(murF)
            HPJ: jhp0677
            CJE: Cj0795c(murF)
            RPR: RP596(murF)
            RCO: RC0911(murF)
            MLO: mll1559
            SME: SMc01862(murF)
            CCR: CC2558
            BSU: BG12084(murF)
            BHA: BH2570(murF)
            SAU: SA1886(murF)
            SAV: SAV2067(murF)
            LLA: L141766(murF)
            SPY: SPy1420(murF)
            SPN: SP1670
            CAC: CAC2128(murF)
            MTU: Rv2157c(murF)
            MTC: MT2216
            MLE: ML0910(murF)
            CTR: CT756
            CMU: TC0137
            CPN: CPn0899
            CPA: CP0967
            CPJ: murF
            BBU: BB0304(murF)
            TPA: TP0386
            SYN: slr1351(murF)
            DRA: DR0768
            AAE: aq_821(murF)
            TMA: TM0236
STRUCTURES  PDB: 1GG4  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.15
            ExPASy - ENZYME nomenclature database: 6.3.2.15
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.15
            BRENDA, the Enzyme Database: 6.3.2.15
            SCOP (Structural Classification of Proteins): 6.3.2.15
///
ENTRY       EC 6.3.2.16
NAME        D-Alanine--alanyl-poly(glycerolphosphate) ligase
            D-Alanyl-alanyl-poly(glycerolphosphate) synthetase
            D-Alanine:membrane-acceptor ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     D-Alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)
REACTION    ATP + D-Alanine + Alanyl-poly(glycerolphosphate) = ADP +
            Orthophosphate + D-Alanyl-alanyl-poly(glycerolphosphate)
SUBSTRATE   ATP
            D-Alanine
            Alanyl-poly(glycerolphosphate)
PRODUCT     ADP
            Orthophosphate
            D-Alanyl-alanyl-poly(glycerolphosphate)
COMMENT     Involved in the synthesis of teichoic acids.
PATHWAY     PATH: MAP00473  D-Alanine metabolism
            PATH: MAP00561  Glycerolipid metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.16
            ExPASy - ENZYME nomenclature database: 6.3.2.16
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.16
            BRENDA, the Enzyme Database: 6.3.2.16
///
ENTRY       EC 6.3.2.17
NAME        Tetrahydrofolylpolyglutamate synthase
            Folylpolyglutamate synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)
REACTION    ATP + Tetrahydrofolyl-[Glu](n) + L-Glutamate = ADP +
            Orthophosphate + Tetrahydrofolyl-[Glu](n+1)
SUBSTRATE   ATP
            Tetrahydrofolyl-[Glu](n)
            L-Glutamate
PRODUCT     ADP
            Orthophosphate
            Tetrahydrofolyl-[Glu](n+1)
COMMENT     The enzymes from different sources (particularly eukaryotes
            versus prokaryotes) have different substrate specificities with
            regard to one-carbon substituents and the number of glutamate
            residues present on the tetrahydrofolates.
PATHWAY     PATH: MAP00790  Folate biosynthesis
GENES       ECO: b2315(folC)
            ECE: Z3577(folC)
            ECS: ECs3199
            YPE: YPO2769(folC)
            HIN: HI1261(folC)
            PMU: PM0635(folC)
            XFA: XF1946
            VCH: VC1001
            PAE: PA3111(folC)
            BUC: BU167(folC)
            NME: NMB0693
            NMA: NMA0896(folC)
            HPY: HP1545(folC)
            HPJ: jhp1454
            CJE: Cj1088c(folC)
            RPR: RP536(folC)
            RCO: RC0779(folC)
            MLO: mlr5076
            SME: SMc02763(folC)
            CCR: CC3541(folC)
            BSU: BG10322(folC)
            BHA: BH3037(folC)
            SAU: SA1487(folC)
            SAV: SAV1646(folC)
            LLA: L0177(folC)
            SPY: SPy0814(folC.2) SPy1096(folC.1)
            CAC: CAC2398(folC)
            MTU: Rv2447c(folC)
            MTC: MT2523
            MLE: ML1471(folC)
            TPA: TP0340
            SYN: sll1612(folC)
            DRA: DR0340
            AAE: aq_2045(folC)
            TMA: TM0166
            HAL: VNG0412G(folP)
            TAC: Ta0637
            TVO: TVG0771612
            SCE: YKL132C(RMA1) YMR113W(FOL3) YOR241W(MET7)
            SPO: SPAC227.09(spac227.09) SPBC1709.17(spbc1709.17)
            CEL: F25B5.6
            DME: CG2543
            MMU: 95576(Fpgs)
            HSA: 2356(FPGS)
DISEASE     MIM: 136510  Folylpolyglutamate synthetase
MOTIF       PS: PS01011  [LIVMFY]-x-[LIVM]-[STAG]-G-T-[NK]-G-K-x-[ST]-x(7)-
                         [LIVM](2)-x(3)-[GSK]
            PS: PS01012  [LIVMFY](2)-E-x-G-[LIVM]-[GA]-G-x(2)-D-x-[GST]-x-
                         [LIVM](2)
STRUCTURES  PDB: 1JBW  1FGS  1JBV  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.17
            ExPASy - ENZYME nomenclature database: 6.3.2.17
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.17
            BRENDA, the Enzyme Database: 6.3.2.17
            SCOP (Structural Classification of Proteins): 6.3.2.17
///
ENTRY       EC 6.3.2.18
NAME        gamma-Glutamylhistamine synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     L-Glutamate:histamine ligase
REACTION    ATP + L-Glutamate + Histamine = ADP or AMP +
            Nalpha-gamma-L-Glutamylhistamine
SUBSTRATE   ATP
            L-Glutamate
            Histamine
PRODUCT     ADP
            AMP
            Nalpha-gamma-L-Glutamylhistamine
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.18
            ExPASy - ENZYME nomenclature database: 6.3.2.18
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.18
            BRENDA, the Enzyme Database: 6.3.2.18
///
ENTRY       EC 6.3.2.19
NAME        Ubiquitin--protein ligase
            Ubiquitin-activating enzyme
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Ubiquitin:protein-lysine N -ligase (AMP-forming)
REACTION    ATP + Ubiquitin + Protein lysine = AMP + Pyrophosphate +
            Protein N-ubiquityllysine
SUBSTRATE   ATP
            Ubiquitin
            Protein lysine
PRODUCT     AMP
            Pyrophosphate
            Protein N-ubiquityllysine
COMMENT     Ubiquitin is coupled to protein by a peptide bond between the
            C-terminal glycine of ubiquitin and epsilon-amino groups of
            lysine residues in the protein. An intermediate in the reaction
            contains one ubiquitin residue bound as a thiolester to the
            enzyme, and a residue of ubiquitin adenylate non-covalently
            bound to the enzyme.
GENES       SCE: YBR082C(UBC4) YDL064W(UBC9) YDR054C(CDC34) YDR059C(UBC5)
                 YDR092W(UBC13) YDR177W(UBC1) YEL012W(UBC8) YER100W(UBC6)
                 YGL058W(RAD6) YGR133W(PEX4) YKL210W(UBA1) YLR306W(UBC12)
                 YMR022W(QRI8) YOR339C(UBC11)
            SPO: HUS5(hus5) RHP6(rhp6) UBC11(ubc11) UBC13(ubc13) UBC15(ubc15)
                 UBC4(ubc4) UBC6(ubc6) UBC8(ubc8) UBCP3(ubcp3)
            ATH: At1g63800(T12P18.18) At1g78870(F9K20.8) At2g02760(T20F6.10)
                 At2g46030(T3F17.29) At3g08690(F17O14.16) At4g27960(T13J8.70)
                 At4g36410(AP22.89)
            CEL: C06E2.3 C35B1.1 C47E12.5 F26H9.7 F29B9.6 F40G9.3 F58A4.10
                 Y54E5B.4 let-70
            DME: CG10682 CG12799(Ubc84D) CG14739 CG1782(Uba1) CG18319(ben)
                 CG2013(UbcD6) CG2257 CG3018(lwr) CG3473(BG:DS01486.1) CG4443
                 CG5788(UbcD10) CG6720(UbcD2) CG7425_1(eff) CG8188
                 CG8284(UbcD4) CG9484(hyd) CG9602
            HSA: 10477(UBE2E3) 11065(UBCH10) 27338(E2-EPF) 3093(HIP2)
                 7317(UBE1) 7319(UBE2A) 7320(UBE2B) 7322(UBE2D2) 7324(UBE2E1)
                 7327(UBE2G2) 7328(UBE2H) 7329(UBE2I) 7337(UBE3A) 9246(UBE2L6)
                 997(CDC34)
DISEASE     MIM: 116948  Cell division cycle 34
            MIM: 179095  Ubiquitin-conjugating enzyme E2B (RAD6 homolog)
            MIM: 312180  Ubiquitin-conjugating enzyme E2A (RAD6 homolog)
            MIM: 601082  Ubiquitin-conjugating enzyme E2H (homologous to yeast
                         UBC8)
            MIM: 601661  Ubiquitin-conjugating enzyme E2I (homologous to yeast
                         UBC9)
MOTIF       PS: PS00183  [FYWLSP]-H-[PC]-[NH]-[LIV]-x(3,4)-G-x-[LIV]-C-[LIV]-x-
                         [LIV]
STRUCTURES  PDB: 2E2C  2UCZ  1I7K  1FZY  1FXT  2AAK  1C4Z  1AYZ  1U9B  1A3S  
                 1U9A  1QCQ  1JBB  1JAT  1FBV  1J7D  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.19
            ExPASy - ENZYME nomenclature database: 6.3.2.19
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.19
            BRENDA, the Enzyme Database: 6.3.2.19
            SCOP (Structural Classification of Proteins): 6.3.2.19
///
ENTRY       EC 6.3.2.20
NAME        Indoleacetate--lysine ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Indoleacetate:L-lysine ligase (ADP-forming)
REACTION    ATP + Indoleacetate + L-Lysine = ADP + Orthophosphate + 
            N6-[(Indole-3-yl)acetyl]-L-lysine
SUBSTRATE   ATP
            Indoleacetate
            L-Lysine
PRODUCT     ADP
            Orthophosphate
            N6-[(Indole-3-yl)acetyl]-L-lysine
MOTIF       PS: PS00455  [LIVMFY]-x(2)-[STG]-[STAG]-G-[ST]-[STEI]-[SG]-x-
                         [PASLIVM]-[KR]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.20
            ExPASy - ENZYME nomenclature database: 6.3.2.20
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.20
            BRENDA, the Enzyme Database: 6.3.2.20
///
ENTRY       EC 6.3.2.21
NAME        Ubiquitin--calmodulin ligase
            Ubiquityl-calmodulin synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Calmodulin:ubiquitin ligase (AMP-forming)
REACTION    n ATP + Calmodulin + n Ubiquitin = n AMP + n Pyrophosphate +
            (Ubiquitin)n-calmodulin
SUBSTRATE   ATP
            Calmodulin
            Ubiquitin
PRODUCT     AMP
            Pyrophosphate
            (Ubiquitin)n-calmodulin
COMMENT     Specific for Ca2+-calmodulin from vertebrates. At least 3
            ubiquitin molecules can be coupled to lysine residues in
            calmodulin.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.21
            ExPASy - ENZYME nomenclature database: 6.3.2.21
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.21
            BRENDA, the Enzyme Database: 6.3.2.21
///
ENTRY       EC 6.3.2.22
NAME        Diphthine--ammonia ligase
            Diphthamide synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     Diphthine:ammonia ligase (ADP-forming)
REACTION    ATP + Diphthine + NH3 = ADP + Orthophosphate + Diphthamide
SUBSTRATE   ATP
            Diphthine
            NH3
PRODUCT     ADP
            Orthophosphate
            Diphthamide
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.22
            ExPASy - ENZYME nomenclature database: 6.3.2.22
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.22
            BRENDA, the Enzyme Database: 6.3.2.22
///
ENTRY       EC 6.3.2.23
NAME        Homoglutathione synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     gamma-L-Glutamyl-L-cysteine:beta-alanine ligase (ADP-forming)
REACTION    ATP + gamma-L-Glutamyl-L-cysteine + beta-Alanine = ADP +
            Orthophosphate + gamma-L-Glutamyl-L-cysteinyl-beta-alanine
SUBSTRATE   ATP
            gamma-L-Glutamyl-L-cysteine
            beta-Alanine
PRODUCT     ADP
            Orthophosphate
            gamma-L-Glutamyl-L-cysteinyl-beta-alanine
COMMENT     Not identical with EC 6.3.2.3.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.23
            ExPASy - ENZYME nomenclature database: 6.3.2.23
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.23
            BRENDA, the Enzyme Database: 6.3.2.23
///
ENTRY       EC 6.3.2.24
NAME        Tyrosine--arginine ligase
            Tyrosyl-arginine synthase
            Kyotorphin synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
SYSNAME     L-Tyrosine:L-arginine ligase (AMP-forming)
REACTION    ATP + L-Tyrosine + L-Arginine = AMP + Pyrophosphate +
            L-Tyrosyl-L-arginine
SUBSTRATE   ATP
            L-Tyrosine
            L-Arginine
PRODUCT     AMP
            Pyrophosphate
            L-Tyrosyl-L-arginine
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.24
            ExPASy - ENZYME nomenclature database: 6.3.2.24
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.24
            BRENDA, the Enzyme Database: 6.3.2.24
///
ENTRY       EC 6.3.2.25
NAME        Tublin-Tyrosine ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Acid--amino-acid ligases (peptide synthases)
REACTION    ATP + [alpha-Tublin] + L-Tyrosine = L-Tyrosyl-[alpha-Tublin]
            + ADP + Phosphate
SUBSTRATE   ATP
            [alpha-Tublin]
            L-Tyrosine
PRODUCT     L-Tyrosyl-[alpha-Tublin]
            ADP
            Phosphate
COMMENT     L-Tyrosine is linked Via a peptide bond to the C-Terminus
            of Detyrosinylated alpha-Tublin.
            The enzyme is extremely specific for alpha-Tublin and
            moderately specific for ATP and L-Tyrosine. L-Phenyl-
            alanine and 3,4-Dehydroxyl-L-phenylalanine are transferred,
            but with higher KM values.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.2.25
            ExPASy - ENZYME nomenclature database: 6.3.2.25
            WIT (What Is There) Metabolic Reconstruction: 6.3.2.25
///
ENTRY       EC 6.3.3.1
NAME        Phosphoribosylformylglycinamidine cyclo-ligase
            Phosphoribosylaminoimidazole synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Cyclo-ligases
SYSNAME     2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase
            (ADP-forming)
REACTION    ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine = ADP +
            Orthophosphate + 1-(5'-Phosphoribosyl)-5-aminoimidazole
SUBSTRATE   ATP
            2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
PRODUCT     ADP
            Orthophosphate
            1-(5'-Phosphoribosyl)-5-aminoimidazole
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2499(purM)
            ECE: Z3762(purM)
            ECS: ECs3361
            HIN: HI1429(purM)
            PMU: PM0021(purM)
            XFA: XF0587
            VCH: VC2226
            PAE: PA0945(purM)
            NME: NMB1252
            NMA: NMA1421(purM)
            CJE: Cj1529c(purM)
            MLO: mll7962
            SME: SMc00615(purM)
            CCR: CC1703
            BSU: BG10708(purM)
            BHA: BH0631(purM)
            SAU: SA0923(purM)
            SAV: SAV1057(purM)
            LLA: L165202(purM)
            SPY: SPy0027(purM)
            SPN: SP0047
            SPR: spr0048(purM)
            CAC: CAC1393(purM)
            MTU: Rv0809(purM)
            MTC: MT0830
            MLE: ML2205(purM)
            SYN: slr0838(purM)
            DRA: DR1394
            AAE: aq_769(purM)
            TMA: TM1251
            MJA: MJ0203(purM)
            MTH: MTH1204
            AFU: AF1693(purM)
            HAL: VNG0876G(purM)
            TAC: Ta0090
            TVO: TVG0175535
            PHO: PH0316
            PAB: PAB1083(purM)
            SSO: SSO0636(purM)
            SCE: YGL234W(ADE5)
            SPO: ADE1(ade1)
            ATH: At3g55010(T15C9.10)
            DME: CG8761(ade3)
            HSA: 2618(GART)
MOTIF       PS: PS00184  R-[LF]-G-D-P-E-x-[EQIM]
            PS: PS00373  G-x-[STM]-[IVT]-x-[FYWVQ]-[VMAT]-x-[DEVM]-x-[LIVMY]-D-
                         x-G-x(2)-[LIVT]-x(6)-[LIVM]
STRUCTURES  PDB: 1CLI  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.3.1
            ExPASy - ENZYME nomenclature database: 6.3.3.1
            WIT (What Is There) Metabolic Reconstruction: 6.3.3.1
            BRENDA, the Enzyme Database: 6.3.3.1
            SCOP (Structural Classification of Proteins): 6.3.3.1
///
ENTRY       EC 6.3.3.2
NAME        5-Formyltetrahydrofolate cyclo-ligase
            5,10-Methenyltetrahydrofolate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Cyclo-ligases
SYSNAME     5-Formyltetrahydrofolate cyclo-ligase (ADP-forming)
REACTION    ATP + 5-Formyltetrahydrofolate = ADP + Orthophosphate +
            5,10-Methenyltetrahydrofolate
SUBSTRATE   ATP
            5-Formyltetrahydrofolate
PRODUCT     ADP
            Orthophosphate
            5,10-Methenyltetrahydrofolate
PATHWAY     PATH: MAP00670  One carbon pool by folate
GENES       RCO: RC0694
            BHA: BH1417
            SPO: SPBC1703.08C(spbc1703.08c)
            CEL: Y106G6E.4
            DME: CG11079
            HSA: 10588(MTHFS)
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.3.2
            ExPASy - ENZYME nomenclature database: 6.3.3.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.3.2
            BRENDA, the Enzyme Database: 6.3.3.2
///
ENTRY       EC 6.3.3.3
NAME        Dethiobiotin synthase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Cyclo-ligases
SYSNAME     7,8-Diaminononanoate:carbon-dioxide cyclo-ligase
            (ADP-forming)
REACTION    ATP + 7,8-Diaminononanoate + CO2 = ADP + Orthophosphate +
            Dethiobiotin
SUBSTRATE   ATP
            7,8-Diaminononanoate
            CO2
            CTP
PRODUCT     ADP
            Orthophosphate
            Dethiobiotin
            CDP
COMMENT     CTP has half the activity of ATP.
PATHWAY     PATH: MAP00780  Biotin metabolism
GENES       ECO: b0778(bioD) b1593
            ECE: Z0997(bioD) Z2585
            ECS: ECs0856 ECs2299
            YPE: YPO1154(bioD) YPO2269(bioD)
            HIN: HI1445(bioD-A) HI1550(bioD-B)
            PMU: PM0641(bioD1) PM1904(bioD2)
            XFA: XF2477
            VCH: VC1115
            PAE: PA0504(bioD)
            BUC: BU290(bioD)
            NME: NMB0733
            NMA: NMA0943(bioD)
            HPY: HP0029(bioD)
            HPJ: jhp0025
            CJE: Cj0308c(bioD)
            MLO: mll5829 mll6005 mll6270 mll9098
            CCR: CC1575
            BSU: BG11526(bioD)
            BHA: BH0783
            SAU: SA2215(bioD)
            SAV: SAV2411(bioD)
            CAC: CAC1361(bioD)
            MTU: Rv1570(bioD)
            MTC: MT1621
            MLE: ML1218(bioD)
            CPN: CPn1042
            CPA: CP0810
            CPJ: bioD
            SYN: slr0523(bioD)
            AAE: aq_557(bioD)
            MJA: MJ1299(bioD)
            SCE: YNR057C(BIO4)
STRUCTURES  PDB: 1A82  1BS1  1BYI  1DAD  1DAE  1DAF  1DAG  1DAH  1DAI  1DAK  
                 1DAM  1DBS  1DTS  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.3.3
            ExPASy - ENZYME nomenclature database: 6.3.3.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.3.3
            BRENDA, the Enzyme Database: 6.3.3.3
            SCOP (Structural Classification of Proteins): 6.3.3.3
///
ENTRY       EC 6.3.4.1
NAME        GMP synthase
            Xanthosine-5'-phosphate--ammonia ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Xanthosine-5'-phosphate:ammonia ligase (AMP-forming)
REACTION    ATP + Xanthosine 5'-phosphate + NH3 = AMP + Pyrophosphate + GMP
SUBSTRATE   ATP
            Xanthosine 5'-phosphate
            NH3
PRODUCT     AMP
            Pyrophosphate
            GMP
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.1
            ExPASy - ENZYME nomenclature database: 6.3.4.1
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.1
            BRENDA, the Enzyme Database: 6.3.4.1
///
ENTRY       EC 6.3.4.2
NAME        CTP synthase
            UTP--ammonia ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     UTP:ammonia ligase(ADP-forming)
REACTION    ATP + UTP + NH3 = ADP + Orthophosphate + CTP
SUBSTRATE   ATP
            UTP
            NH3
            Glutamine
PRODUCT     ADP
            Orthophosphate
            CTP
            Glutamate
COMMENT     Glutamine can replace NH3.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
GENES       ECO: b2780(pyrG)
            ECE: Z4095(pyrG)
            ECS: ECs3640
            YPE: YPO3377(pyrG)
            HIN: HI1077(pyrG)
            PMU: PM1872(pyrG)
            XFA: XF1288
            VCH: VC2448
            PAE: PA3637(pyrG)
            BUC: BU416(pyrG)
            NME: NMB1554
            NMA: NMA1742(pyrG)
            HPY: HP0349(pyrG)
            HPJ: jhp0323
            CJE: Cj0027(pyrG)
            RPR: RP378(pyrG)
            RCO: RC0523(pyrG)
            MLO: mll0606
            SME: SMc01025(pyrG)
            CCR: CC1720
            BSU: BG10410(pyrG)
            BHA: BH3792(ctrA)
            SAU: SA1929(ctrA)
            SAV: SAV2114(ctrA)
            LLA: L88252(pyrG)
            SPY: SPy1894(pyrG)
            SPN: SP0494
            SPR: spr0438(pyrG)
            CAC: CAC2892(ctrA)
            MPU: MYPU_6660(pyrG)
            UUR: UU284(pyrG)
            MTU: Rv1699(pyrG)
            MTC: MT1738
            MLE: ML1363(pyrG)
            CTR: CT183
            CMU: TC0455
            CPN: CPn0236
            CPA: CP0526
            CPJ: pyrG
            BBU: BB0575(pyrG)
            TPA: TP0305
            SYN: sll1443(pyrG)
            DRA: DR1573
            AAE: aq_1334(pyrG)
            TMA: TM0803
            MJA: MJ1174(pyrG)
            MTH: MTH419
            AFU: AF0252(pyrG)
            HAL: VNG1830G(pyrG)
            TAC: Ta0044
            TVO: TVG0036820
            PHO: PH1792
            PAB: PAB0231(pyrG)
            APE: APE1604
            SSO: SSO0201(pyrG)
            STO: ST0237
            SCE: YBL039C(URA7) YJR103W(URA8)
            SPO: SPAC10F6.03C(spac10f6.03c)
            ATH: At4g02120(T10M13.13)
            CEL: W06H3.3
            DME: CG6854 CG6854_1
            HSA: 1503(CTPS)
DISEASE     MIM: 123860  Cytidine 5'-triphosphate synthetase
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.2
            ExPASy - ENZYME nomenclature database: 6.3.4.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.2
            BRENDA, the Enzyme Database: 6.3.4.2
///
ENTRY       EC 6.3.4.3
NAME        Formate--tetrahydrofolate ligase
            Formyltetrahydrofolate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Formate:tetrahydrofolate ligase (ADP-forming)
REACTION    ATP + Formate + Tetrahydrofolate = ADP + Orthophosphate +
            10-Formyltetrahydrofolate
SUBSTRATE   ATP
            Formate
            Tetrahydrofolate
PRODUCT     ADP
            Orthophosphate
            10-Formyltetrahydrofolate
COMMENT     In eukaryotes occurs as a trifunctional enzyme also having
            methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) and
            methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity.
PATHWAY     PATH: MAP00630  Glyoxylate and dicarboxylate metabolism
            PATH: MAP00670  One carbon pool by folate
            PATH: MAP00790  Folate biosynthesis
GENES       VCH: VCA0614
            NME: NMB1839
            NMA: NMA0617(fhs)
            MLO: mlr2763
            SME: SMc02728(fhs)
            SAU: SA1553(fhs)
            SAV: SAV1719(fhs)
            LLA: L159505(fhs)
            SPY: SPy1213(fhs.1) SPy2085(fhs.2)
            SPN: SP1229
            SPR: spr1109(fhs)
            CAC: CAC3201
            UUR: UU221(fthS)
            TMA: TM1766
            TAC: Ta1478
            TVO: TVG0090326
            SCE: YBR084W(MIS1) YGR204W(ADE3)
            SPO: SPBC2G2.08(spbc2g2.08) SPBC839.16(spbc839.16)
            HSA: 4522(MTHFD1)
DISEASE     MIM: 172460  5,10-methylenetetrahydrofolate dehydrogenase,
MOTIF       PS: PS00721  G-[LIVM]-K-G-G-A-A-G-G-G-Y
            PS: PS00722  V-A-T-[IV]-R-A-L-K-x-[HN]-G-G
            PS: PS00766  [EQ]-x-[EQK]-[LIVM](2)-x(2)-[LIVM]-x(2)-[LIVMY]-N-x-
                         [DN]-x(5)-[LIVMF](3)-Q-L-P-[LV]
            PS: PS00767  P-G-G-V-G-P-[MF]-T-[IV]
STRUCTURES  PDB: 1FPM  1EG7  1FP7  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.3
            ExPASy - ENZYME nomenclature database: 6.3.4.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.3
            BRENDA, the Enzyme Database: 6.3.4.3
            SCOP (Structural Classification of Proteins): 6.3.4.3
///
ENTRY       EC 6.3.4.4
NAME        Adenylosuccinate synthase
            IMP--aspartate ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     IMP:L-aspartate ligase (GDP-forming)
REACTION    GTP + IMP + L-Aspartate = GDP + Orthophosphate +
            N6-(1,2-Dicarboxyethyl)-AMP
SUBSTRATE   GTP
            IMP
            L-Aspartate
PRODUCT     GDP
            Orthophosphate
            N6-(1,2-Dicarboxyethyl)-AMP
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00252  Alanine and aspartate metabolism
GENES       ECO: b4177(purA)
            ECE: Z5784(purA)
            ECS: ECs5153
            YPE: YPO0378(purA)
            HIN: HI1633(purA)
            PMU: PM0938(purA)
            XFA: XF0455
            VCH: VC2602
            PAE: PA4938(purA)
            BUC: BU566(purA)
            NME: NMB0815
            NMA: NMA1024(purA)
            HPY: HP0255(purA)
            HPJ: jhp0239
            CJE: Cj1498c(purA)
            MLO: mll3873
            SME: SMc00643(purA)
            CCR: CC3103
            BSU: BG10002(purA)
            BHA: BH4028(purA)
            SAU: SA0016(purA)
            SAV: SAV0017(purA)
            LLA: L12179(purA)
            SPY: SPy0160(purA)
            SPN: SP0019
            SPR: spr0021(purA)
            CAC: CAC3593(purA)
            MTU: Rv0357c(purA)
            MTC: MT0373
            MLE: ML0280(purA)
            SYN: sll1823(purA)
            DRA: DR0035
            AAE: aq_1290(purA)
            TMA: TM1096
            MJA: MJ0561(purA)
            MTH: MTH615
            AFU: AF0841(purA)
            HAL: VNG1089G(purA)
            TAC: Ta1367
            TVO: TVG0301512
            PHO: PH0438
            PAB: PAB1303(purA)
            SSO: SSO0242(purA)
            STO: ST0291
            SCE: YNL220W(ADE12)
            SPO: ADE2(ade2)
            ATH: At3g57610(F15B8.200)
            CEL: C37H5.6
            DME: CG17273(BcDNA:LD32788)
            HSA: 159(ADSS)
DISEASE     MIM: 103060  Adenylosuccinate synthetase (Ade(-)H-complementing)
MOTIF       PS: PS00513  G-I-[GR]-P-x-Y-x(2)-K-x(2)-R
            PS: PS01266  Q-W-G-D-E-G-K-G
STRUCTURES  PDB: 1SON  1QF5  1QF4  1NHT  1KSZ  1JUY  1SOO  1ADE  1ADI  1CG0  
                 1CG1  1CG3  1CG4  1CH8  1CIB  1DJ2  1DJ3  1GIM  1GIN  1HON  
                 1HOO  1HOP  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.4
            ExPASy - ENZYME nomenclature database: 6.3.4.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.4
            BRENDA, the Enzyme Database: 6.3.4.4
            SCOP (Structural Classification of Proteins): 6.3.4.4
///
ENTRY       EC 6.3.4.5
NAME        Argininosuccinate synthase
            Citrulline--aspartate ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     L-Citrulline:L-aspartate ligase (AMP-forming)
REACTION    ATP + L-Citrulline + L-Aspartate = AMP + Pyrophosphate +
            N(omega)-(L-Arginino)succinate
SUBSTRATE   ATP
            L-Citrulline
            L-Aspartate
PRODUCT     AMP
            Pyrophosphate
            N(omega)-(L-Arginino)succinate
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
GENES       ECO: b3172(argG)
            ECE: Z4534(argG)
            ECS: ECs4052
            YPE: YPO1570(argG)
            HIN: HI1727(argG)
            PMU: PM0813(argG)
            XFA: XF0999
            VCH: VC2642
            PAE: PA3525(argG)
            BUC: BU050(argG)
            NME: NMB2129
            NMA: NMA0303(argG)
            CJE: Cj0665c(argG)
            MLO: mlr4366
            SME: SMc03826(argG)
            CCR: CC0129
            BSU: BG12570(argG)
            BHA: BH3187(argG)
            SAU: SA0822(argG)
            SAV: SAV0948(argG)
            LLA: L126739(argG)
            SPR: spr0102(argG)
            CAC: CAC0973(argG)
            MTU: Rv1658(argG)
            MTC: MT1696
            MLE: ML1412(argG)
            SYN: slr0585(argG)
            DRA: DR0674
            AAE: aq_1140(argG)
            TMA: TM1780
            MJA: MJ0429(argG)
            MTH: MTH1254
            AFU: AF2252(argG)
            HAL: VNG2437G(argG)
            TAC: Ta0650
            TVO: TVG0978186 TVG0979194
            SSO: SSO0638(argG)
            SCE: YOL058W(ARG1)
            SPO: SPBC428.05C(spbc428.05c)
            DME: CG1315(BG:DS00004.14)
            MMU: 88090(Ass1)
            HSA: 445(ASS)
DISEASE     MIM: 603470  Argininosuccinate synthetase
MOTIF       PS: PS00564  [AS]-[FY]-S-G-G-[LV]-D-T-[ST]
            PS: PS00565  G-x-T-x-K-G-N-D-x(2)-R-F
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.5
            ExPASy - ENZYME nomenclature database: 6.3.4.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.5
            BRENDA, the Enzyme Database: 6.3.4.5
///
ENTRY       EC 6.3.4.6
NAME        Urea carboxylase
            Urease (ATP-hydrolysing)
            Urea carboxylase (hydrolysing)
            ATP--urea amidolyase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Urea:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Urea + CO2 = ADP + Orthophosphate + Urea-1-carboxylate
SUBSTRATE   ATP
            Urea
            CO2
PRODUCT     ADP
            Orthophosphate
            Urea-1-carboxylate
COFACTOR    Biotin
COMMENT     A biotinyl-protein. The yeast enzyme (but not that from green
            algae) also catalyses the reaction of EC 3.5.1.54, thus bringing
            about the hydrolysis of urea to CO2 and NH3.  Previously also
            listed as EC 3.5.1.45.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00910  Nitrogen metabolism
GENES       SCE: YBR208C(DUR1)
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.6
            ExPASy - ENZYME nomenclature database: 6.3.4.6
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.6
            BRENDA, the Enzyme Database: 6.3.4.6
///
ENTRY       EC 6.3.4.7
NAME        Ribose-5-phosphate--ammonia ligase
            5-Phosphoribosylamine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Ribose-5-phosphate:ammonia ligase (ADP-forming)
REACTION    ATP + D-Ribose 5-phosphate + NH3 = ADP + Orthophosphate +
            5-Phosphoribosylamine
SUBSTRATE   ATP
            D-Ribose 5-phosphate
            NH3
PRODUCT     ADP
            Orthophosphate
            5-Phosphoribosylamine
PATHWAY     PATH: MAP00230  Purine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.7
            ExPASy - ENZYME nomenclature database: 6.3.4.7
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.7
            BRENDA, the Enzyme Database: 6.3.4.7
///
ENTRY       EC 6.3.4.8
NAME        Imidazoleacetate--phosphoribosyldiphosphate ligase
            5-Phosphoribosylimidazoleacetate synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and
            $ pyrophosphate- forming)
REACTION    ATP + Imidazole-4-acetate + 5-Phosphoribosyl diphosphate = ADP +
            Orthophosphate + 1-(5-Phosphoribosyl)imidazole-4-acetate +
            Pyrophosphate
SUBSTRATE   ATP
            Imidazole-4-acetate
            5-Phosphoribosyl diphosphate
PRODUCT     ADP
            Orthophosphate
            1-(5-Phosphoribosyl)imidazole-4-acetate
            Pyrophosphate
PATHWAY     PATH: MAP00340  Histidine metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.8
            ExPASy - ENZYME nomenclature database: 6.3.4.8
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.8
            BRENDA, the Enzyme Database: 6.3.4.8
///
ENTRY       EC 6.3.4.9
NAME        Biotin--[methylmalonyl-CoA-carboxyltransferase] ligase
            Biotin-[methylmalonyl-CoA-carboxyltransferase] synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase
            $ (AMP-forming)
REACTION    ATP + Biotin + Apo-[methylmalonyl-CoA:pyruvate
            $ carboxyltransferase] = AMP + Pyrophosphate + [Methylmalonyl-
            $CoA:pyruvate carboxyltransferase]
SUBSTRATE   ATP
            Biotin
            Apo-[methylmalonyl-CoA:pyruvate carboxyltransferase]
PRODUCT     AMP
            Pyrophosphate
            [Methylmalonyl-CoA:pyruvate carboxyltransferase]
DISEASE     MIM: 253270  Holocarbyoxylase synthetase
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.9
            ExPASy - ENZYME nomenclature database: 6.3.4.9
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.9
            BRENDA, the Enzyme Database: 6.3.4.9
///
ENTRY       EC 6.3.4.10
NAME        Biotin--[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
            Biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Biotin:apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
            $ ligase (AMP-forming)
REACTION    ATP + Biotin + Apo-[propionyl-CoA:carbon-dioxide ligase
            $ (ADP-forming)] = AMP + Pyrophosphate +
            [Propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
SUBSTRATE   ATP
            Biotin
            Apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
PRODUCT     AMP
            Pyrophosphate
            [Propionyl-CoA:carbon-dioxide ligase (ADP-forming)]
PATHWAY     PATH: MAP00780  Biotin metabolism
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.10
            ExPASy - ENZYME nomenclature database: 6.3.4.10
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.10
            BRENDA, the Enzyme Database: 6.3.4.10
///
ENTRY       EC 6.3.4.11
NAME        Biotin--[methylcrotonoyl-CoA-carboxylase] ligase
            Biotin-[methylcrotonyl-CoA-carboxylase] synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase
            $ (ADP-forming)] ligase (AMP-forming)
REACTION    ATP + Biotin + Apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase
            $ (ADP-forming)] = AMP + Pyrophosphate +
            [3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
SUBSTRATE   ATP
            Biotin
            Apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
PRODUCT     AMP
            Pyrophosphate
            [3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.11
            ExPASy - ENZYME nomenclature database: 6.3.4.11
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.11
            BRENDA, the Enzyme Database: 6.3.4.11
///
ENTRY       EC 6.3.4.12
NAME        Glutamate--methylamine ligase
            gamma-Glutamylmethylamide synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     L-Glutamate:methylamine ligase (ADP-forming)
REACTION    ATP + L-Glutamate + Methylamine = ADP + Orthophosphate +
            N5-Methyl-L-glutamine
SUBSTRATE   ATP
            L-Glutamate
            Methylamine
PRODUCT     ADP
            Orthophosphate
            N5-Methyl-L-glutamine
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.12
            ExPASy - ENZYME nomenclature database: 6.3.4.12
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.12
            BRENDA, the Enzyme Database: 6.3.4.12
///
ENTRY       EC 6.3.4.13
NAME        Phosphoribosylamine--glycine ligase
            Phosphoribosylglycinamide synthetase
            Glycinamide ribonucleotide synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
REACTION    ATP + 5-Phospho-D-ribosylamine + Glycine = ADP + Orthophosphate +
            N1-(5-Phospho-D-ribosyl)glycinamide
SUBSTRATE   ATP
            5-Phospho-D-ribosylamine
            Glycine
PRODUCT     ADP
            Orthophosphate
            N1-(5-Phospho-D-ribosyl)glycinamide
COMMENT     Formerly EC 6.3.1.3.
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b4005(purD)
            ECE: Z5582(purD)
            ECS: ECs4928
            YPE: YPO3729(purD)
            HIN: HI0888(purD)
            PMU: PM0224(purD)
            XFA: XF1976
            VCH: VC0275
            PAE: PA4855(purD)
            NME: NMB2151
            NMA: NMA0238(purD)
            HPY: HP1218(purD)
            HPJ: jhp1140
            CJE: Cj1250(purD)
            MLO: mlr7447
            SME: SMc00993(purD)
            CCR: CC0297
            BSU: BG10711(purD)
            BHA: BH0634(purD)
            SAU: SA0926(purD)
            SAV: SAV1060(purD)
            LLA: L153005(purD)
            SPY: SPy0032(purD)
            SPN: SP0051
            SPR: spr0052(purD)
            CAC: CAC1396(purD)
            MTU: Rv0772(purD)
            MTC: MT0796
            MLE: ML2235(purD)
            SYN: slr1159(purD)
            DRA: DR1431
            AAE: aq_742(purD)
            TMA: TM1250
            MJA: MJ0937(purD)
            MTH: MTH1445
            AFU: AF1157(purD)
            HAL: VNG1305G(purD)
            TAC: Ta0594 Ta0595
            TVO: TVG0617128
            PHO: PH0323
            PAB: PAB1271(purD)
            SSO: SSO0635(purD)
            SCE: YGL234W(ADE5)
            SPO: ADE1(ade1)
            ATH: At1g09830(F21M12.22)
            CEL: F38B6.4
            DME: CG8761(ade3)
            MMU: 107658(Ifnar) 95654(Gart)
            HSA: 2618(GART)
DISEASE     MIM: 138440  Phosphoribosylglycinamide formyltransferase
                         (phosphoribosylglycinamide
MOTIF       PS: PS00184  R-[LF]-G-D-P-E-x-[EQIM]
            PS: PS00373  G-x-[STM]-[IVT]-x-[FYWVQ]-[VMAT]-x-[DEVM]-x-[LIVMY]-D-
                         x-G-x(2)-[LIVT]-x(6)-[LIVM]
STRUCTURES  PDB: 1GSO  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.13
            ExPASy - ENZYME nomenclature database: 6.3.4.13
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.13
            BRENDA, the Enzyme Database: 6.3.4.13
            SCOP (Structural Classification of Proteins): 6.3.4.13
///
ENTRY       EC 6.3.4.14
NAME        Biotin carboxylase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Biotin-carboxyl-carrier-protein:carbon-dioxide ligase
            (ADP-forming)
REACTION    ATP + Biotin-carboxyl-carrier protein + CO2 = ADP + Orthophosphate
            + Carboxybiotin-carboxyl-carrier protein
SUBSTRATE   ATP
            Biotin-carboxyl-carrier protein
            CO2
PRODUCT     ADP
            Orthophosphate
            Carboxybiotin-carboxyl-carrier protein
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
GENES       ECO: b3256(accC)
            ECE: Z4616(accC)
            ECS: ECs4128
            YPE: YPO3658(accC)
            HIN: HI0972(accC)
            PMU: PM1091(accC)
            XFA: XF0049
            VCH: VC0295
            PAE: PA0494 PA2891 PA4848(accC)
            NME: NMB1861
            NMA: NMA0596(accC)
            HPY: HP0370(accC)
            HPJ: jhp1011
            CJE: Cj1290c(accC)
            MLO: mll0203
            SME: SMc01345(accC)
            CCR: CC1884
            BSU: BG11384(accC) BG13459(yngH)
            BHA: BH1132 BH2787(accC)
            SAU: SA1357(accC) SA1434
            SAV: SAV1515(accC) SAV1594
            LLA: L0189(accC)
            SPY: SPy1745(accC)
            SPN: SP0425
            SPR: spr0385(accC)
            CAC: CAC3570(accC)
            MTU: Rv2501c(accA1) Rv3285(accA3)
            MTC: MT2576 MT3384
            MLE: ML0726(bccA)
            CTR: CT124
            CMU: TC0400
            CPN: CPn0182
            CPA: CP0586
            CPJ: accC
            SYN: sll0053(accC)
            DRA: DR0117
            AAE: aq_1470(accC2) aq_1664(accC1)
            SCE: YNR016C(ACC1)
            SPO: CUT6_1(cut6) CUT6_2(cut6)
            DME: CG8723
            HSA: 31(ACACA) 32(ACACB)
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
STRUCTURES  PDB: 1DV2  1DV1  1BNC  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.14
            ExPASy - ENZYME nomenclature database: 6.3.4.14
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.14
            BRENDA, the Enzyme Database: 6.3.4.14
            SCOP (Structural Classification of Proteins): 6.3.4.14
///
ENTRY       EC 6.3.4.15
NAME        Biotin--[acetyl-CoA-carboxylase] ligase
            Biotin-[acetyl-CoA-carboxylase] synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Biotin:apo-[acetyl-CoA:carbondioxide ligase (ADP-forming)] ligase
            (AMP-forming)
REACTION    ATP + Biotin + Apo-[acetyl-CoA:carbon-dioxide ligase
            $ (ADP-forming)] = AMP + Pyrophosphate + [Acetyl-CoA:carbon-dioxide
            $ ligase (ADP-forming)]
SUBSTRATE   ATP
            Biotin
            Apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]
PRODUCT     AMP
            Pyrophosphate
            [Acetyl-CoA:carbon-dioxide ligase (ADP-forming)]
GENES       ECO: b3973(birA)
            ECE: Z5544(birA)
            ECS: ECs4900
            YPE: YPO3759(birA)
            HIN: HI0220.1(birA)
            PMU: PM0296(birA)
            XFA: XF1796
            VCH: VC0319
            PAE: PA4280(birA)
            NME: NMB2075
            NMA: NMA0357(birA)
            HPY: HP1140(birA)
            HPJ: jhp1068
            CJE: Cj0099(birA)
            RPR: RP533(birA)
            RCO: RC0773(birA)
            MLO: mll1351
            SME: SMc01928(birA)
            CCR: CC1936
            BSU: BG11206(birA)
            BHA: BH1685(birA)
            SAU: SA1289
            SAV: SAV1445(birA)
            LLA: L0191(birA1) L0192(birA2)
            SPY: SPy1362(birA)
            SPN: SP1900
            CAC: CAC0212 CAC0589(birA)
            MTU: Rv3279c(birA)
            MTC: MT3379
            MLE: ML0732(birA)
            CTR: CT725
            CMU: TC0098
            CPN: CPn0866
            CPA: CP1003
            CPJ: birA
            TPA: TP0357
            SYN: sll1655(birA)
            DRA: DR2341
            AAE: aq_566(birA)
            TMA: TM0224
            MJA: MJ1619(birA)
            MTH: MTH1916
            AFU: AF0074(birA)
            PHO: PH0147
            PAB: PAB0096(birA) PAB0104(birA-like)
            SSO: SSO0662(bioR)
STRUCTURES  PDB: 1HXD  1BIB  1BIA  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.15
            ExPASy - ENZYME nomenclature database: 6.3.4.15
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.15
            BRENDA, the Enzyme Database: 6.3.4.15
            SCOP (Structural Classification of Proteins): 6.3.4.15
///
ENTRY       EC 6.3.4.16
NAME        Carbamoyl-phosphate synthase (ammonia)
            Carbon-dioxide--ammonia ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Carbon-dioxide:ammonia ligase (ADP-forming,
            carbamate-phosphorylating)
REACTION    2 ATP + NH3 + CO2 + H2O = 2 ADP + Orthophosphate +
            Carbamoyl phosphate
SUBSTRATE   ATP
            NH3
            CO2
            H2O
PRODUCT     ADP
            Orthophosphate
            Carbamoyl phosphate
EFFECTOR    N-Acetyl-L-glutamate
COMMENT     Formerly EC 2.7.2.5.  Requires N-acetylglutamate as allosgteric
            activator.
PATHWAY     PATH: MAP00220  Urea cycle and metabolism of amino groups
            PATH: MAP00251  Glutamate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       HSA: 1373(CPS1)
DISEASE     MIM: 237300  Carbamoyl-phosphate synthetase 1, mitochondrial
MOTIF       PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.16
            ExPASy - ENZYME nomenclature database: 6.3.4.16
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.16
            BRENDA, the Enzyme Database: 6.3.4.16
///
ENTRY       EC 6.3.4.17
NAME        Formate--dihydrofolate ligase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Other carbon--nitrogen ligases
SYSNAME     Formate:dihydrofolate ligase (ADP-forming)
REACTION    ATP + Formate + Dihydrofolate = ADP + Orthophosphate +
            10-Formyldihydrofolate
SUBSTRATE   ATP
            Formate
            Dihydrofolate
PRODUCT     ADP
            Orthophosphate
            10-Formyldihydrofolate
COMMENT     Not identical with EC 6.3.4.3.
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.4.17
            ExPASy - ENZYME nomenclature database: 6.3.4.17
            WIT (What Is There) Metabolic Reconstruction: 6.3.4.17
            BRENDA, the Enzyme Database: 6.3.4.17
///
ENTRY       EC 6.3.5.1
NAME        NAD+ synthase (glutamine-hydrolysing)
            NAD+ synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     Deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
REACTION    ATP + Deamido-NAD+ + L-Glutamine + H2O = AMP + Pyrophosphate +
            NAD+ + L-Glutamate
SUBSTRATE   ATP
            Deamido-NAD+
            L-Glutamine
            H2O
            NH3
PRODUCT     AMP
            Pyrophosphate
            NAD+
            L-Glutamate
COMMENT     NH3 can act instead of glutamine. (cf. EC 6.3.1.5).
PATHWAY     PATH: MAP00251  Glutamate metabolism
            PATH: MAP00760  Nicotinate and nicotinamide metabolism
GENES       ECO: b1740(nadE)
            ECE: Z2770(nadE)
            ECS: ECs2446
            YPE: YPO2912(nadE)
            XFA: XF1961
            VCH: VCA0207
            PAE: PA4920(nadE)
            BUC: BU174(nadE)
            NME: NMB1364
            NMA: NMA1576(nadE)
            HPY: HP0329(nadE)
            HPJ: jhp0312
            CJE: Cj0810(nadE)
            MLO: mll0818
            SME: SMc00161(nadE2)
            CCR: CC3619
            BSU: BG10694(nadE)
            BHA: BH2285(nadE)
            SAU: SA1728(nadE)
            SAV: SAV1897(nadE)
            LLA: L0203(nadE)
            SPY: SPy1652(nadE)
            SPN: SP1420
            SPR: spr1276(nadE)
            CAC: CAC1050(nadE) CAC1782(nadE)
            MGE: MG383(nade)
            MPN: H03_orf248(outB)
            MPU: MYPU_6230(nadE)
            UUR: UU460(nadE)
            MTU: Rv2438c
            MLE: ML1463
            BBU: BB0522
            TPA: TP0780
            SYN: slr1691(nadE)
            DRA: DRA0201
            AAE: aq_959(nadE)
            TMA: TM0645 TM1253
            MJA: MJ1352(nadE)
            MTH: MTH1510
            AFU: AF1000(nadE)
            HAL: VNG2031G(nadE)
            TAC: Ta0899
            TVO: TVG1071522
            PHO: PH0182
            PAB: PAB2244(nadE)
            APE: APE1958
            SSO: SSO2172(nadE)
            SPO: SPCC553.02(spcc553.02)
            DME: CG9940
STRUCTURES  PDB: 1EE1  1FYD  1IFX  1IH8  1NSY  2NSY  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.5.1
            ExPASy - ENZYME nomenclature database: 6.3.5.1
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.1
            BRENDA, the Enzyme Database: 6.3.5.1
            SCOP (Structural Classification of Proteins): 6.3.5.1
///
ENTRY       EC 6.3.5.2
NAME        GMP synthase (glutamine-hydrolysing)
            GMP synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     Xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
REACTION    ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O = AMP +
            Pyrophosphate + GMP + L-Glutamate
SUBSTRATE   ATP
            Xanthosine 5'-phosphate
            L-Glutamine
            H2O
PRODUCT     AMP
            Pyrophosphate
            GMP
            L-Glutamate
INHIBITOR   Psicofuranin
COMMENT     Psicofuranine, 6-amino-9-D-psiscofuranosylpurine, prevents
            reaction of adenyl-XMP with NH3. Glutamine amidotransferase
            domian (type G) has a SH protease-like catalytic residues.
PATHWAY     PATH: MAP00230  Purine metabolism
            PATH: MAP00251  Glutamate metabolism
GENES       ECO: b2507(guaA)
            ECE: Z3771(guaA)
            ECS: ECs3369
            YPE: YPO2870(guaA)
            HIN: HI0222(guaA)
            PMU: PM0293(guaA)
            XFA: XF2429
            VCH: VC0768
            PAE: PA3769(guaA)
            NME: NMB1920
            NMA: NMA0534(guaA)
            HPY: HP0409(guaA)
            HPJ: jhp0972
            CJE: Cj1248(guaA)
            MLO: mlr6950
            SME: SMc00394(guaA)
            CCR: CC1620
            BSU: BG10647(guaA)
            BHA: BH0607(guaA)
            SAU: SA0376(guaA)
            SAV: SAV0380(yjbM)
            LLA: L115968(guaA)
            SPY: SPy1204(guaA)
            SPN: SP1445
            SPR: spr1300(guaA)
            CAC: CAC2700(guaA)
            MTU: Rv3396c(guaA)
            MTC: MT3504
            MLE: ML0395(guaA)
            CMU: TC0442
            CPN: CPn0171
            CPA: CP0599
            CPJ: guaA
            BBU: BBB18(guaA)
            SYN: slr0213(guaA)
            DRA: DR1874
            AAE: aq_236(guaA)
            TMA: TM1820
            MJA: MJ1131(guaA) MJ1575(guaA)
            MTH: MTH709 MTH710
            AFU: AF0253(guaA-1) AF1320(guaA-2)
            HAL: VNG0228G(guaAa) VNG1829G(guaAb)
            TAC: Ta0944 Ta1361
            TVO: TVG0306280 TVG1144148
            PHO: PH1346 PH1347
            PAB: PAB0549(guaA-N) PAB2417(guaA-C)
            APE: APE2452
            SSO: SSO2451(guaA) SSO3232(guaA)
            STO: ST0578
            SCE: YMR217W(GUA1)
            CEL: M106.4
            DME: CG9242
            HSA: 8833(GMPS)
DISEASE     MIM: 600358  Guanine monophosphate synthetase
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
STRUCTURES  PDB: 1GPM  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.5.2
            ExPASy - ENZYME nomenclature database: 6.3.5.2
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.2
            BRENDA, the Enzyme Database: 6.3.5.2
            SCOP (Structural Classification of Proteins): 6.3.5.2
///
ENTRY       EC 6.3.5.3
NAME        Phosphoribosylformylglycinamidine synthase
            Phosphoribosylformylglycinamidine synthetase
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase
            (ADP-forming)
REACTION    ATP + 5'-Phosphoribosyl-N-formylglycinamide + L-Glutamine + H2O =
            ADP + Orthophosphate + 5'-Phosphoribosyl-N-formylglycinamidine +
            L-Glutamate
SUBSTRATE   ATP
            5'-Phosphoribosyl-N-formylglycinamide
            L-Glutamine
            H2O
PRODUCT     ADP
            Orthophosphate
            5'-Phosphoribosyl-N-formylglycinamidine
            L-Glutamate
PATHWAY     PATH: MAP00230  Purine metabolism
GENES       ECO: b2557(purL)
            ECE: Z3835(purL)
            ECS: ECs3423
            YPE: YPO2921(purL)
            HIN: HI0752(purL)
            PMU: PM1085(purL)
            XFA: XF1423
            VCH: VC0869
            PAE: PA3763(purL)
            NME: NMB1996
            NMA: NMA0445(purL)
            CJE: Cj0514(purQ) Cj0955c(purL)
            MLO: mll0057 mll0065
            SME: SMc00488(purL) SMc00493(purQ)
            CCR: CC2497 CC2500
            BSU: BG10705(purL) BG10706(purQ)
            BHA: BH0628(purL) BH0629(purQ)
            SAU: SA0920(purQ) SA0921(purL)
            SAV: SAV1054(purQ) SAV1055(purL)
            LLA: L173921(purL) L176360(purQ)
            SPY: SPy0025
            SPN: SP0045
            SPR: spr0046(purL)
            CAC: CAC1655(purQ/purL)
            MTU: Rv0788(purQ) Rv0803(purL)
            MTC: MT0813 MT0823
            MLE: ML2211(purL) ML2219(purQ)
            SYN: sll1056(purL) slr0520(purL)
            DRA: DR0222 DR0223
            AAE: aq_1105(purQ) aq_1836(purL)
            TMA: TM1245 TM1246
            MJA: MJ1264(purL) MJ1648(purQ)
            MTH: MTH1374(purL) MTH168
            AFU: AF1260(purQ) AF1940(purL)
            HAL: VNG0864G(purL) VNG1945G(purL2)
            TAC: Ta1066 Ta1318
            TVO: TVG0280999 TVG0510425
            PHO: PH1953 PH1955
            PAB: PAB1200(purQ) PAB1201(purL)
            SSO: SSO0628(purQ) SSO0629(purL)
            SCE: YGR061C(ADE6)
            SPO: ADE3(ade3)
            CEL: F10F2.2
            DME: CG9127(ade2)
            HSA: 5198(PFAS)
DISEASE     MIM: 602133  phosphoribosylformylglycinamidine synthase (FGAR
                         amidotransferase)
MOTIF       PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.5.3
            ExPASy - ENZYME nomenclature database: 6.3.5.3
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.3
            BRENDA, the Enzyme Database: 6.3.5.3
///
ENTRY       EC 6.3.5.4
NAME        Asparagine synthase (glutamine-hydrolysing)
            Asparagine synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     L-Aspartate:L-glutamine amido-ligase (AMP-forming)
REACTION    ATP + L-Aspartate + L-Glutamine = AMP + Pyrophosphate +
            L-Asparagine + L-Glutamate
SUBSTRATE   ATP
            L-Aspartate
            L-Glutamine
PRODUCT     AMP
            Pyrophosphate
            L-Asparagine
            L-Glutamate
COMMENT     Type F glutamine amidotransferase.
PATHWAY     PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00910  Nitrogen metabolism
GENES       ECO: b0674(asnB)
            ECE: Z0821(asnB)
            ECS: ECs0704
            YPE: YPO2623(asnB)
            XFA: XF0118
            VCH: VC0991
            PAE: PA0051 PA2084 PA3459
            MLO: mll6743 mlr5888 mlr6755
            SME: SMb20481(asnO) SMb20652(asnB)
            BSU: BG11116(asnH) BG11831(asnB) BG12240(asnO)
            BHA: BH1508
            LLA: L00396(asnB) L0095(asnH)
            CAC: CAC2243(asnB)
            MTU: Rv2201(asnB)
            MTC: MT2257
            MLE: ML0874(asnB)
            MJA: MJ1056(asnB) MJ1116
            MTH: MTH414
            AFU: AF1439(asnB)
            HAL: VNG0867G(asnA)
            PHO: PH1102
            PAB: PAB0750(asnB) PAB1605
            APE: APE2041
            SCE: YGR124W(ASN2) YPR145W(ASN1)
            SPO: SPBC119.10(spbc119.10)
            CEL: F25G6.6 M02D8.4
            HSA: 440(ASNS)
DISEASE     MIM: 108370  Asparagine synthetase
MOTIF       PS: PS00443  <x(0,11)-C-[GS]-[IV]-[LIVMFYW]-[AG]
STRUCTURES  PDB: 1CT9  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.5.4
            ExPASy - ENZYME nomenclature database: 6.3.5.4
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.4
            BRENDA, the Enzyme Database: 6.3.5.4
            SCOP (Structural Classification of Proteins): 6.3.5.4
///
ENTRY       EC 6.3.5.5
NAME        Carbamoyl-phosphate synthase (glutamine-hydrolysing)
            Carbamoyl-phosphate synthetase (glutamine-hydrolysing)
CLASS       Ligases
            Forming carbon-nitrogen bonds
            Carbon--nitrogen ligases with glutamine as amido-N-donor
SYSNAME     Carbon-dioxide:L-glutamine amido-ligase (ADP-forming,
            carbamate-phosphorylating)
REACTION    2 ATP + L-Glutamine + CO2 + H2O = 2 ADP + Orthophosphate +
            L-Glutamate + Carbamoyl phosphate
SUBSTRATE   ATP
            L-Glutamine
            CO2
            H2O
PRODUCT     ADP
            Orthophosphate
            L-Glutamate
            Carbamoyl phosphate
COMMENT     Formerly EC 2.7.2.9.
            Glutamine amidotransferase domian (type G) has SH protease-
            like catalytic residues.
PATHWAY     PATH: MAP00240  Pyrimidine metabolism
            PATH: MAP00251  Glutamate metabolism
GENES       ECO: b0032(carA) b0033(carB)
            ECE: Z0037(carA) Z0038(carB)
            ECS: ECs0035 ECs0036
            YPE: YPO0481(carA) YPO0482(carB)
            PMU: PM1502(carA) PM1505(carB)
            XFA: XF1106 XF1107
            VCH: VC2389 VC2390
            PAE: PA4756(carB) PA4758(carA)
            BUC: BU144(carB) BU145(carA)
            NME: NMB1849 NMB1855
            NMA: NMA0602(carB) NMA0608(carA)
            HPY: HP0919(pyrAb) HP1237(pyrAa)
            HPJ: jhp0853 jhp1158
            CJE: Cj0279(carB) Cj1494c(carA)
            MLO: mlr2489 mlr2517
            SME: SMb21227 SMc01215(carB) SMc01569(carA)
            CCR: CC2834 CC2900
            BSU: BG10195(carA) BG10196(carB) BG10715(pyrAA) BG10716(pyrAB)
            BHA: BH2536(pyrAB) BH2537(pyrAA) BH2895(carB) BH2896(carA)
            SAU: SA1045(pyrAA) SA1046(pyrAB)
            SAV: SAV1189(pyrAA) SAV1190(pyrAB)
            LLA: L198033(carB) L43866(carA)
            SPY: SPy0833(carA) SPy0835(carB)
            SPN: SP1275 SP1276
            SPR: spr1153(carB) spr1154(carA)
            CAC: CAC2644(carB) CAC2645(carA)
            MTU: Rv1383(carA)
            MTC: MT1427 MT1428
            MLE: ML0535(carA) ML0536(carB)
            SYN: sll0370(carB) sll1498(carA)
            DRA: DR0668 DR0684
            AAE: aq_1172(carB1) aq_2101(carB2) aq_410(carA)
            TMA: TM0557 TM0558
            MJA: MJ1019(carA) MJ1378(carB1) MJ1381(carB2)
            MTH: MTH996 MTH997 MTH998
            AFU: AF1273(carA) AF1274(carB)
            HAL: VNG1814G(carB) VNG1815G(carA)
            TAC: Ta0791 Ta0792
            TVO: TVG0820736 TVG0823863
            SSO: SSO0640(carA) SSO0641(carB)
            SCE: YJL130C(URA2) YJR109C(CPA2) YOR303W(CPA1)
            SPO: SPBC215.08C(spbc215.08c) SPBC56F2.09C(spbc56f2.09c)
                 URA1(ura1)
            ATH: At1g29900(F1N18.6) At3g27740(MGF10.14)
            CEL: D2085.1
            HSA: 790(CAD)
DISEASE     MIM: 114010  CAD trifunctional protein of pyrimidine biosynthesis
MOTIF       PS: PS00097  F-x-[EK]-x-S-[GT]-R-T
            PS: PS00442  [PAS]-[LIVMFYT]-[LIVMFY]-G-[LIVMFY]-C-[LIVMFYN]-G-x-
                         [QEH]-x-[LIVMFA]
            PS: PS00482  D-[LIVMFYWSAP]-H-[LIVA]-H-[LIVF]-[RN]-x-[PGANF]
            PS: PS00483  [GA]-[ST]-D-x-A-P-H-x(4)-K
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
STRUCTURES  PDB: 1BXR  1C30  1C3O  1CE8  1CS0  1JDB  
DBLINKS     IUBMB Enzyme Nomenclature: 6.3.5.5
            ExPASy - ENZYME nomenclature database: 6.3.5.5
            WIT (What Is There) Metabolic Reconstruction: 6.3.5.5
            BRENDA, the Enzyme Database: 6.3.5.5
            SCOP (Structural Classification of Proteins): 6.3.5.5
///
ENTRY       EC 6.4.1.1
NAME        Pyruvate carboxylase
            Pyruvic carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Pyruvate:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Pyruvate + HCO3- = ADP + Orthophosphate + Oxaloacetate
SUBSTRATE   ATP
            Pyruvate
            HCO3-
PRODUCT     ADP
            Orthophosphate
            Oxaloacetate
COFACTOR    Biotin
            Manganese
            Zinc
            Acetyl-CoA
COMMENT     A biotinyl-protein containing manganese (animal tissues) or
            zinc (yeast). The animal enzyme requires acetyl-CoA.
PATHWAY     PATH: MAP00020  Citrate cycle (TCA cycle)
            PATH: MAP00252  Alanine and aspartate metabolism
            PATH: MAP00620  Pyruvate metabolism
GENES       PAE: PA1400 PA5435 PA5436
            CJE: Cj0933c(pycB) Cj1037c(pycA)
            MLO: mll3969
            SME: SMc03895(pyc)
            ATU: AGR_C_4940
            CCR: CC3214
            BSU: BG12660(pycA)
            BHA: BH2625(pycA)
            SAU: SA0963(pycA)
            SAV: SAV1097(pycA)
            LLA: L63652(pycA)
            CAC: CAC2660(pykA)
            MTU: Rv2967c(pca)
            MTC: MT3045
            DRA: DRA0310
            AAE: aq_1517(pycB) aq_1520(pycA)
            MJA: MJ1229(accC) MJ1231(oadA)
            MTH: MTH1107 MTH1917
            AFU: AF0220(acc)
            HAL: VNG1532G(acc)
            SSO: SSO2466(accC)
            STO: ST0593
            SCE: YBR218C(PYC2) YGL062W(PYC1)
            SPO: PYR1(pyr1)
            CEL: D2023.2
            DME: CG1516 CG1516_2(BcDNA:GH06348)
            MMU: 97520(Pcx)
            HSA: 5091
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.4.1.1
            ExPASy - ENZYME nomenclature database: 6.4.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.1
            BRENDA, the Enzyme Database: 6.4.1.1
///
ENTRY       EC 6.4.1.2
NAME        Acetyl-CoA carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Acetyl-CoA:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Acetyl-CoA + HCO3- = ADP + Orthophosphate + Malonyl-CoA
SUBSTRATE   ATP
            Acetyl-CoA
            Propanonyl-CoA
            Butanoyl-CoA
            HCO3-
PRODUCT     ADP
            Orthophosphate
            Malonyl-CoA
INHIBITOR   (RS)-2-[4-(3-Chloro-5-(trifluoromethyl-2-pyridyloxy)phenoxy]-
            $propionic acid
COFACTOR    Biotin
COMMENT     A biotinyl-protein. Also catalyses transcarboxylation; the plant
            enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.
PATHWAY     PATH: MAP00061  Fatty acid biosynthesis (path 1)
            PATH: MAP00253  Tetracycline biosynthesis
            PATH: MAP00620  Pyruvate metabolism
            PATH: MAP00640  Propanoate metabolism
GENES       ECO: b0185(accA) b2316(accD)
            ECE: Z0197(accA) Z3578(accD)
            ECS: ECs0187 ECs3200
            YPE: YPO1060(accA) YPO2768(accD)
            HIN: HI0406(accA) HI1260(accD)
            PMU: PM0292(accA) PM0636(accD)
            XFA: XF0203 XF1467
            VCH: VC1000 VC2244
            PAE: PA3112(accD) PA3639(accA)
            NME: NMB0679 NMB1139 NMB1177
            NMA: NMA0880(accD) NMA1349(accA)
            HPY: HP0557(accA) HP0950(accD)
            HPJ: jhp0504 jhp0884
            CJE: Cj0127c(accD) Cj0443(accA)
            MLO: mlr3576 mlr5075
            SME: SMc00690(accA) SMc02764(accD)
            CCR: CC2995 CC3542
            BSU: BG12557(accA) BG13926(accD)
            BHA: BH3165(accA) BH3166(accD)
            SAU: SA1522(accA) SA1523
            SAV: SAV1686(accA) SAV1687
            LLA: L0180(accD) L0190(accA)
            SPY: SPy1743(accA) SPy1744(accD)
            SPN: SP0426 SP0427
            SPR: spr0386(accD) spr0387(accA)
            CAC: CAC3568(accA) CAC3569(accD)
            MTU: Rv0904c(accD3)
            MTC: MT0927
            CTR: CT265 CT293
            CMU: TC0536 TC0566
            CPN: CPn0058 CPn0414
            CPA: CP0340 CP0717
            CPJ: accA accD
            SYN: sll0336(accD) sll0728(accA)
            DRA: DR1214 DR1215
            AAE: aq_1206(accA) aq_445(accD)
            SCE: YNR016C(ACC1)
            SPO: CUT6_1(cut6) CUT6_2(cut6)
            CEL: W09B6.1
            DME: CG8723
            HSA: 31(ACACA) 32(ACACB)
DISEASE     MIM: 200350  Acetyl-Coenzyme A carboxylase, alpha
            MIM: 601557  Acetyl-Coenzyme A carboxylase, beta
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
STRUCTURES  PDB: 1A6X  1BDO  2BDO  3BDO  
DBLINKS     IUBMB Enzyme Nomenclature: 6.4.1.2
            ExPASy - ENZYME nomenclature database: 6.4.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.2
            BRENDA, the Enzyme Database: 6.4.1.2
            SCOP (Structural Classification of Proteins): 6.4.1.2
///
ENTRY       EC 6.4.1.3
NAME        Propionyl-CoA carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Propanoyl-CoA:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Propanoyl-CoA + HCO3- = ADP + Orthophosphate +
            (S)-Methylmalonyl-CoA
SUBSTRATE   ATP
            Propanoyl-CoA
            Butanoyl-CoA
            HCO3-
PRODUCT     ADP
            Orthophosphate
            (S)-Methylmalonyl-CoA
COFACTOR    Biotin
COMMENT     A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses
            transcarboxylation.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
            PATH: MAP00640  Propanoate metabolism
GENES       PAE: PA2012 PA2014 PA2888
            RPR: RP618(pccA) RP619(pccB)
            RCO: RC0959(pccA) RC0960(pccB)
            MLO: mll0348 mll0871 mll6012 mll7731
            SME: SMb20755(pccB) SMb20756(pccA)
            CCR: CC1975 CC2168 CC2170 CC2179
            BSU: BG11733(yqjD) BG13456(yngE)
            BHA: BH1136
            MTU: Rv0973c(accA2) Rv0974c(accD2) Rv2247(accD6) Rv2502c(accD1)
                 Rv3280(accD5) Rv3799c(accD4)
            MTC: MT1001 MT3379.1
            MLE: ML0102(accD4) ML0731(accD5) ML1657
            DRA: DR1316 DR1542
            HAL: VNG0623G(yngE)
            CEL: F02A9.4a F27D9.5 F52E4.1
            DME: CG3267(Eb1)
            HSA: 5095(PCCA) 5096(PCCB)
DISEASE     MIM: 232000  Propionyl Coenzyme A carboxylase, alpha polypeptide
            MIM: 232050  Propionyl Coenzyme A carboxylase, beta polypeptide
MOTIF       PS: PS00188  [GN]-[DEQTR]-x-[LIVMFY]-x(2)-[LIVM]-x-[AIV]-M-K-[LMAT]-
                         x(3)-[LIVM]-x-[SAV]
            PS: PS00866  [FYV]-[PS]-[LIVMC]-[LIVMA]-[LIVM]-[KR]-[PSA]-[STA]-
                         x(3)-[SG]-G-x-[AG]
            PS: PS00867  [LIVMF]-[LIMN]-E-[LIVMCA]-N-[PATLIVM]-[KR]-[LIVMSTAC]
DBLINKS     IUBMB Enzyme Nomenclature: 6.4.1.3
            ExPASy - ENZYME nomenclature database: 6.4.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.3
            BRENDA, the Enzyme Database: 6.4.1.3
///
ENTRY       EC 6.4.1.4
NAME        Methylcrotonoyl-CoA carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + 3-Methylcrotonoyl-CoA + HCO3- = ADP + Orthophosphate +
            3-Methylglutaconyl-CoA
SUBSTRATE   ATP
            3-Methylcrotonoyl-CoA
            HCO3-
PRODUCT     ADP
            Orthophosphate
            3-Methylglutaconyl-CoA
COFACTOR    Biotin
COMMENT     A biotinyl-protein.
PATHWAY     PATH: MAP00280  Valine, leucine and isoleucine degradation
GENES       SME: SMb21122(mccA) SMb21124(mccB)
            HSA: 56922(MCCC1) 64087(MCCC2)
DBLINKS     IUBMB Enzyme Nomenclature: 6.4.1.4
            ExPASy - ENZYME nomenclature database: 6.4.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.4
            BRENDA, the Enzyme Database: 6.4.1.4
///
ENTRY       EC 6.4.1.5
NAME        Geranoyl-CoA carboxylase
CLASS       Ligases
            Forming carbon-carbon bonds
SYSNAME     Geranoyl-CoA:carbon-dioxide ligase (ADP-forming)
REACTION    ATP + Geranoyl-CoA + HCO3- = ADP + Orthophosphate +
            3-(4-Methylpent-3-en-1-yl)-pent-2-enedioyl-CoA
SUBSTRATE   ATP
            Geranoyl-CoA
            HCO3-
PRODUCT     ADP
            Orthophosphate
            3-(4-Methylpent-3-en-1-yl)-pent-2-enedioyl-CoA
COFACTOR    Biotin
COMMENT     A biotinyl-protein. Also carboxylates dimethylpropenoyl-CoA and
            farnesoyl-CoA.
DBLINKS     IUBMB Enzyme Nomenclature: 6.4.1.5
            ExPASy - ENZYME nomenclature database: 6.4.1.5
            WIT (What Is There) Metabolic Reconstruction: 6.4.1.5
            BRENDA, the Enzyme Database: 6.4.1.5
///
ENTRY       EC 6.5.1.1
NAME        DNA ligase (ATP)
            Polydeoxyribonucleotide synthase (ATP)
            Polynucleotide ligase
            Sealase
            DNA repair enzyme
            DNA joinase
CLASS       Ligases
            Forming phosphoric ester bonds
SYSNAME     Poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase
            (AMP-forming)
REACTION    ATP + (Deoxyribonucleotide)n + (Deoxyribonucleotide)m = AMP +
            Pyrophosphate + (Deoxyribonucleotide)n+m
SUBSTRATE   ATP
            (Deoxyribonucleotide)n
            (Deoxyribonucleotide)m
            (Ribonucleotide)n
            (Ribonucleotide)m
PRODUCT     AMP
            Pyrophosphate
            (Deoxyribonucleotide)n+m
            (Ribonucleotide)n+m
COMMENT     Catalyses the formation of a phosphodiester at the site of a
            single-strand break in duplex DNA. RNA can also act as substrate
            to some extent.
GENES       HIN: HI1182(ligA) HI1183(ligA)
            VCH: VC1542
            NME: NMB2048
            NMA: NMA0388
            CJE: Cj1669c
            MLO: mll5481 mll9685
            SME: SMb20912 SMb21044 SMc03177
            CCR: CC3610
            BSU: BG13680(ligB)
            MTU: Rv3062(ligB)
            MTC: MT3148
            AAE: aq_1394(lig)
            MJA: MJ0171(lig)
            MTH: MTH1580(lig)
            AFU: AF0623(lig) AF1725
            HAL: VNG0881G(lig)
            TAC: Ta1148
            TVO: TVG1298537
            PHO: PH1622
            PAB: PAB2002(lig)
            APE: APE1094
            SSO: SSO0189(lig)
            STO: ST0223
            SCE: YDL164C(CDC9) YOR005C(DNL4)
            SPO: CDC17(cdc17)
            CEL: C29A12.3
            DME: CG17227 CG5602
            MMU: 101789(Lig1)
            HSA: 3978(LIG1) 3979(LIG2) 3980(LIG3) 3981(LIG4)
DISEASE     MIM: 126391  Ligase I, DNA, ATP-dependent
            MIM: 600940  Ligase III, DNA, ATP-dependent
            MIM: 601837  Ligase IV, DNA, ATP-dependent
MOTIF       PS: PS00333  E-G-[LIVMA]-[LIVM](2)-[KR]-x(5,8)-[YW]-[QNEK]-x(2,6)-
                         [KRH]-x(3,5)-K-[LIVMFY]-K
            PS: PS00347  C-[KR]-x-C-x(3)-I-x-K-x(3)-[RG]-x(16,18)-W-[FYH]-H-
                         x(2)-C
            PS: PS00697  [EDQH]-x-K-x-[DN]-G-x-R-[GACIVM]
            PS: PS50064  Poly(ADP-ribose) polymerase zinc finger domain profile
STRUCTURES  PDB: 1A0I  1IMO  1IN1  
DBLINKS     IUBMB Enzyme Nomenclature: 6.5.1.1
            ExPASy - ENZYME nomenclature database: 6.5.1.1
            WIT (What Is There) Metabolic Reconstruction: 6.5.1.1
            BRENDA, the Enzyme Database: 6.5.1.1
            SCOP (Structural Classification of Proteins): 6.5.1.1
///
ENTRY       EC 6.5.1.2
NAME        DNA ligase (NAD+)
            Polydeoxyribonucleotide synthase (NAD+)
            Polynucleotide ligase (NAD+)
            DNA repair enzyme
            DNA joinase
CLASS       Ligases
            Forming phosphoric ester bonds
SYSNAME     Poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase
            (AMP-forming, NMN-forming)
REACTION    NAD+ + (Deoxyribonucleotide)n + (Deoxyribonucleotide)m = AMP +
            Nicotinamide D-ribonucleotide + (Deoxyribonucleotide)n+m
SUBSTRATE   NAD+
            (Deoxyribonucleotide)n
            (Deoxyribonucleotide)m
            (Ribonucleotide)n
            (Ribonucleotide)m
PRODUCT     AMP
            Nicotinamide D-ribonucleotide
            (Deoxyribonucleotide)n+m
            (Ribonucleotide)n+m
COMMENT     Catalyses the formation of a phosphodiester at the site of a
            single-strand break in duplex DNA. RNA can also act as substrate
            to some extent.
GENES       ECO: b2411(lig)
            ECE: Z3677(lig)
            ECS: ECs3283
            YPE: YPO2989(ligA)
            HIN: HI1100(ligN)
            PMU: PM1716(lig)
            XFA: XF2556
            VCH: VC0971
            PAE: PA1529(lig)
            BUC: BU067(lig)
            NME: NMB0666
            NMA: NMA0865(ligA)
            HPY: HP0615(lig)
            HPJ: jhp0558
            CJE: Cj0586(ligA)
            RPR: RP720(lig)
            RCO: RC1096(lig)
            MLO: mll1539
            SME: SMb20008 SMb20686 SMc01878(ligA)
            CCR: CC1522
            BSU: BG12835(ligA)
            BHA: BH0649(lig)
            SAU: SA1720(lig)
            SAV: SAV1889(lig)
            LLA: L0304(ligA)
            SPY: SPy0751(lig)
            SPN: SP1117
            SPR: spr1024(ligA)
            CAC: CAC1195(ligA) CAC2673
            MGE: MG254(lig)
            MPN: H91_orf658(lig)
            MPU: MYPU_3890(lig) MYPU_4010(lig)
            UUR: UU121(lig)
            MTU: Rv3014c(ligA)
            MTC: MT3094
            MLE: ML1705(ligA)
            CTR: CT146
            CMU: TC0423
            CPN: CPn0149
            CPA: CP0624
            CPJ: dnlJ
            BBU: BB0552(lig)
            TPA: TP0634
            SYN: sll1209(lig) sll1583(lig)
            DRA: DR2069
            AAE: aq_633(ligA)
            TMA: TM0100
MOTIF       PS: PS01055  K-[LIVM]-D-G-[LIVM]-[SA]-x(4)-Y-x(2)-G-x-[LF]-x(4)-
                         [ST]-R-G-[DN]-G-x(2)-G-[DE]-[DENL]
            PS: PS01056  [IV]-G-[KR]-[ST]-G-x-[LIVM]-[STNK]-x-[VT]-x(2)-L-x-
                         [PS]-[IV]
STRUCTURES  PDB: 1B04  1DGS  1DGT  
DBLINKS     IUBMB Enzyme Nomenclature: 6.5.1.2
            ExPASy - ENZYME nomenclature database: 6.5.1.2
            WIT (What Is There) Metabolic Reconstruction: 6.5.1.2
            BRENDA, the Enzyme Database: 6.5.1.2
            SCOP (Structural Classification of Proteins): 6.5.1.2
///
ENTRY       EC 6.5.1.3
NAME        RNA ligase (ATP)
            Polyribonucleotide synthase (ATP)
CLASS       Ligases
            Forming phosphoric ester bonds
SYSNAME     Poly(ribonucleotide):poly(ribonucleotide) ligase(AMP-forming)
REACTION    ATP + RNA(linear) = AMP + Pyrophosphate + RNA(circular)
SUBSTRATE   ATP
            RNA(linear)
PRODUCT     AMP
            Pyrophosphate
            RNA(circular)
COMMENT     Converts linear RNA to a circular form by transfer of the
            5'-phosphate to the 3'-hydroxyl terminus.
GENES       SCE: YJL087C(TRL1)
DBLINKS     IUBMB Enzyme Nomenclature: 6.5.1.3
            ExPASy - ENZYME nomenclature database: 6.5.1.3
            WIT (What Is There) Metabolic Reconstruction: 6.5.1.3
            BRENDA, the Enzyme Database: 6.5.1.3
///
ENTRY       EC 6.5.1.4
NAME        RNA-3'-phosphate cyclase
            RNA cyclase
CLASS       Ligases
            Forming phosphoric ester bonds
SYSNAME     RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
REACTION    ATP + RNA 3'-terminal-phosphate = AMP + Pyrophosphate +
            RNA terminal-2',3'-cyclic-phosphate
SUBSTRATE   ATP
            RNA 3'-terminal-phosphate
            Adenosine 5'-(gamma-thio)triphosphate
PRODUCT     AMP
            Pyrophosphate
            RNA terminal-2',3'-cyclic-phosphate
COMMENT     Adenosine 5'-(gamma-thio)triphosphate can act instead of ATP.
GENES       ECO: b3419(yhgJ) b3420(yhgK)
            ECE: Z4778
            ECS: ECs4263
            PAE: PA4585(rtcA)
            AAE: aq_642
            MJA: MJ0025(rtcA)
            MTH: MTH1915
            AFU: AF1435
            HAL: VNG0732G(tpc)
            PHO: PH1529
            PAB: PAB1943
            APE: APE0511
            SSO: SSO2446(rtcA)
            STO: ST0570
            SCE: YOL010W(RTC1)
            SPO: SPAC12G12.06C(spac12g12.06c)
            CEL: ZK1127.5
            DME: CG11130(Rtc1) CG4061(EG:22E5.3)
            HSA: 10171(RNAC) 8634(RPC)
MOTIF       PS: PS01287  [RH]-G-x(2)-P-x-G(3)-x-[LIV]
STRUCTURES  PDB: 1QMH  1QMI  
DBLINKS     IUBMB Enzyme Nomenclature: 6.5.1.4
            ExPASy - ENZYME nomenclature database: 6.5.1.4
            WIT (What Is There) Metabolic Reconstruction: 6.5.1.4
            BRENDA, the Enzyme Database: 6.5.1.4
            SCOP (Structural Classification of Proteins): 6.5.1.4
///
